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Total number of protein in "GO:0031349" GO term:  139

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
ADAM8 ADAM8 P78325 Disintegrin and metalloproteinase domain-containing protein 8 chr10 GO:0031349 Not Cancer Driver No 82 0.1 230 13 0.057 0
ADORA2B ADORA2B P29275 Adenosine receptor A2b chr17 GO:0031349 Not Cancer Driver No 23 0.069 0 0 0.0 0
ALOX5AP_ENST00000380490 ALOX5AP P20292 Arachidonate 5-lipoxygenase-activating protein chr13 GO:0031349 Not Cancer Driver No 17 0.106 1 0 0.0 0
AP1G1_ENST00000569748 AP1G1 O43747 AP-1 complex subunit gamma-1 chr16 GO:0031349 Not Cancer Driver No 111 0.135 144 22 0.153 0
ARG1_ENST00000368087 ARG1 P05089 Arginase-1 chr6 GO:0031349 Not Cancer Driver No 41 0.127 83 12 0.145 9
BTK_ENST00000308731 BTK Q06187 Tyrosine-protein kinase BTK chrX GO:0031349 Census, Compendium Yes 147 0.223 114 27 0.237 110
C2CD4A C2CD4A Q8NCU7 C2 calcium-dependent domain-containing protein 4A chr15 GO:0031349 Not Cancer Driver No 13 0.035 223 4 0.018 0
C2CD4B C2CD4B A6NLJ0 C2 calcium-dependent domain-containing protein 4B chr15 GO:0031349 Not Cancer Driver No 5 0.014 191 0 0.0 0
C3 C3 P01024 Complement C3 chr19 GO:0031349 Not Cancer Driver No 337 0.203 287 50 0.174 12
CADM1_ENST00000452722 CADM1 Q9BY67 Cell adhesion molecule 1 chr11 GO:0031349 Not Cancer Driver No 106 0.24 103 28 0.272 0
CCR7 CCR7 P32248 C-C chemokine receptor type 7 chr17 GO:0031349 Census, Compendium Yes 50 0.132 0 0 0.0 0
CD160_ENST00000369288 CD160 O95971 CD160 antigen chr1 GO:0031349 Not Cancer Driver No 20 0.11 2 0 0.0 0
CD226_ENST00000582621 CD226 Q15762 CD226 antigen chr18 GO:0031349 Not Cancer Driver No 79 0.235 47 11 0.234 0
CD28 CD28 P10747 T-cell-specific surface glycoprotein CD28 chr2 GO:0031349 Census Yes 42 0.191 18 10 0.556 0
CD81 CD81 P60033 CD81 antigen chr11 GO:0031349 Not Cancer Driver No 28 0.119 0 0 0.0 0
CLEC6A CLEC6A Q6EIG7 C-type lectin domain family 6 member A chr12 GO:0031349 Not Cancer Driver No 41 0.196 7 0 0.0 0
CLEC7A CLEC7A Q9BXN2 C-type lectin domain family 7 member A chr12 GO:0031349 Not Cancer Driver No 43 0.174 46 2 0.043 0
CLNK CLNK Q7Z7G1 Cytokine-dependent hematopoietic cell linker chr4 GO:0031349 Not Cancer Driver No 85 0.199 320 73 0.228 0
CNR1_ENST00000549890 CNR1 P21554 Cannabinoid receptor 1 chr6 GO:0031349 Not Cancer Driver No 129 0.273 9 1 0.111 0
CREB3L3 CREB3L3 Q68CJ9 Cyclic AMP-responsive element-binding protein 3-like protein 3 chr19 GO:0031349 Not Cancer Driver No 96 0.208 338 67 0.198 1
CREBBP CREBBP Q92793 CREB-binding protein chr16 GO:0031349 Census, Compendium Yes 412 0.169 1796 247 0.138 33
CRTAM CRTAM O95727 Cytotoxic and regulatory T-cell molecule chr11 GO:0031349 Not Cancer Driver No 64 0.163 135 14 0.104 0
CTSC CTSC P53634 Dipeptidyl peptidase 1 chr11 GO:0031349 Not Cancer Driver No 64 0.138 19 5 0.263 29
CYBA CYBA P13498 Cytochrome b-245 light chain chr16 GO:0031349 Not Cancer Driver No 26 0.133 66 2 0.03 12
EMILIN1 EMILIN1 Q9Y6C2 EMILIN-1 chr2 GO:0031349 Not Cancer Driver No 125 0.123 669 69 0.103 0
EMILIN2 EMILIN2 Q9BXX0 EMILIN-2 chr18 GO:0031349 Not Cancer Driver No 158 0.15 617 94 0.152 0
EP300 EP300 Q09472 Histone acetyltransferase p300 chr22 GO:0031349 Census, Compendium Yes 334 0.138 1790 196 0.109 1
F2RL1 F2RL1 P55085 Proteinase-activated receptor 2 chr5 GO:0031349 Not Cancer Driver No 55 0.139 7 2 0.286 0
FADD FADD Q13158 FAS-associated death domain protein chr11 GO:0031349 Not Cancer Driver No 26 0.125 45 10 0.222 1
FAM19A3_ENST00000361886 TAFA3 Q7Z5A8 Chemokine-like protein TAFA-3 chr1 GO:0031349 Not Cancer Driver No 17 0.128 6 0 0.0 0
FCN1 FCN1 O00602 Ficolin-1 chr9 GO:0031349 Not Cancer Driver No 107 0.328 88 15 0.17 0
FFAR2 FFAR2 O15552 Free fatty acid receptor 2 chr19 GO:0031349 Not Cancer Driver No 49 0.148 32 7 0.219 0
FFAR3 FFAR3 O14843 Free fatty acid receptor 3 chr19 GO:0031349 Not Cancer Driver No 78 0.225 29 6 0.207 0
FYN FYN P06241 Tyrosine-protein kinase Fyn chr6 GO:0031349 Not Cancer Driver No 92 0.171 70 13 0.186 0
GRN GRN P28799 Progranulin chr17 GO:0031349 Not Cancer Driver No 76 0.128 29 6 0.207 1
HAVCR2 HAVCR2 Q8TDQ0 Hepatitis A virus cellular receptor 2 chr5 GO:0031349 Not Cancer Driver No 69 0.229 17 2 0.118 3
HCK_ENST00000534862 HCK P08631 Tyrosine-protein kinase HCK chr20 GO:0031349 Not Cancer Driver No 112 0.213 124 25 0.202 0
HLA-E HLA-E P13747 HLA class I histocompatibility antigen, alpha chain E chr6 GO:0031349 Not Cancer Driver No 63 0.176 138 39 0.283 0
HLA-F_ENST00000376861 HLA-F P30511 HLA class I histocompatibility antigen, alpha chain F chr6 GO:0031349 Not Cancer Driver No 43 0.124 115 22 0.191 0
HLA-G_ENST00000360323 HLA-G P17693 HLA class I histocompatibility antigen, alpha chain G chr6 GO:0031349 Not Cancer Driver No 94 0.278 85 22 0.259 0
HPX HPX P02790 Hemopexin chr11 GO:0031349 Not Cancer Driver No 60 0.13 53 8 0.151 0
IDO1_ENST00000522495 IDO1 P14902 Indoleamine 2,3-dioxygenase 1 chr8 GO:0031349 Not Cancer Driver No 82 0.203 41 8 0.195 0
IKBKB IKBKB O14920 Inhibitor of nuclear factor kappa-B kinase subunit beta chr8 GO:0031349 Census, Compendium Yes 106 0.14 211 31 0.147 1
IKBKE IKBKE Q14164 Inhibitor of nuclear factor kappa-B kinase subunit epsilon chr1 GO:0031349 Not Cancer Driver No 108 0.151 76 13 0.171 0
IL12B IL12B P29460 Interleukin-12 subunit beta chr5 GO:0031349 Not Cancer Driver No 48 0.146 42 2 0.048 0
IL18 IL18 Q14116 Interleukin-18 chr11 GO:0031349 Not Cancer Driver No 19 0.098 16 3 0.188 0
IL1B IL1B P01584 Interleukin-1 beta chr2 GO:0031349 Not Cancer Driver No 39 0.145 16 3 0.188 0
IL33 IL33 O95760 Interleukin-33 chr9 GO:0031349 Not Cancer Driver No 47 0.174 47 8 0.17 0
IL6 IL6 P05231 Interleukin-6 chr7 GO:0031349 Not Cancer Driver No 35 0.165 58 7 0.121 0
IL6ST_ENST00000336909 IL6ST P40189 Interleukin-6 receptor subunit beta chr5 GO:0031349 Census, Compendium Yes 102 0.111 315 40 0.127 2
IRF3_ENST00000597198 IRF3 Q14653 Interferon regulatory factor 3 chr19 GO:0031349 Not Cancer Driver No 36 0.084 204 21 0.103 1
IRF7_ENST00000397574 IRF7 Q92985 Interferon regulatory factor 7 chr11 GO:0031349 Not Cancer Driver No 43 0.085 253 19 0.075 1
IRGM IRGM A1A4Y4 Immunity-related GTPase family M protein chr5 GO:0031349 Not Cancer Driver No 9 0.05 45 1 0.022 0
KARS_ENST00000302445 KARS1 Q15046 Lysine--tRNA ligase chr16 GO:0031349 Not Cancer Driver No 88 0.147 160 15 0.094 12
KLK3 KLK3 P07288 Prostate-specific antigen chr19 GO:0031349 Not Cancer Driver No 68 0.261 6 1 0.167 0
KLK5_ENST00000593428 KLK5 Q9Y337 Kallikrein-5 chr19 GO:0031349 Not Cancer Driver No 69 0.235 75 16 0.213 0
KLK7 KLK7 P49862 Kallikrein-7 chr19 GO:0031349 Not Cancer Driver No 43 0.17 38 8 0.211 0
KLRC2 KLRC2 P26717 NKG2-C type II integral membrane protein chr12 GO:0031349 Not Cancer Driver No 55 0.238 45 17 0.378 0
KLRC3_ENST00000396439 KLRC3 Q07444 NKG2-E type II integral membrane protein chr12 GO:0031349 Not Cancer Driver No 37 0.154 43 4 0.093 0
KLRC4 KLRC4 O43908 NKG2-F type II integral membrane protein chr12 GO:0031349 Not Cancer Driver No 36 0.228 45 7 0.156 0
KLRD1 KLRD1 Q13241 Natural killer cells antigen CD94 chr12 GO:0031349 Not Cancer Driver No 37 0.207 0 0 0.0 0
KLRK1 KLRK1 P26718 NKG2-D type II integral membrane protein chr12 GO:0031349 Not Cancer Driver No 38 0.176 0 0 0.0 0
LAMP1 LAMP1 P11279 Lysosome-associated membrane glycoprotein 1 chr13 GO:0031349 Not Cancer Driver No 47 0.113 93 10 0.108 0
LBP LBP P18428 Lipopolysaccharide-binding protein chr20 GO:0031349 Not Cancer Driver No 84 0.175 6 0 0.0 0
LILRA2 LILRA2 Q8N149 Leukocyte immunoglobulin-like receptor subfamily A member 2 chr19 GO:0031349 Not Cancer Driver No 163 0.337 137 44 0.321 0
LRRK2 LRRK2 Q5S007 Leucine-rich repeat serine/threonine-protein kinase 2 chr12 GO:0031349 Not Cancer Driver No 519 0.205 90 17 0.189 23
LRSAM1_ENST00000373322 LRSAM1 Q6UWE0 E3 ubiquitin-protein ligase LRSAM1 chr9 GO:0031349 Not Cancer Driver No 86 0.119 240 30 0.125 1
LSM14A_ENST00000433627 LSM14A Q8ND56 Protein LSM14 homolog A chr19 GO:0031349 Census Yes 67 0.145 408 63 0.154 0
LTA LTA P01374 Lymphotoxin-alpha chr6 GO:0031349 Not Cancer Driver No 37 0.18 20 5 0.25 0
LYN LYN P07948 Tyrosine-protein kinase Lyn chr8 GO:0031349 Census Yes 95 0.186 84 12 0.143 0
MAP3K7 MAP3K7 O43318 Mitogen-activated protein kinase kinase kinase 7 chr6 GO:0031349 Not Cancer Driver No 104 0.172 333 66 0.198 6
MAPK3 MAPK3 P27361 Mitogen-activated protein kinase 3 chr16 GO:0031349 Not Cancer Driver No 38 0.1 49 5 0.102 0
MAVS MAVS Q7Z434 Mitochondrial antiviral-signaling protein chr20 GO:0031349 Not Cancer Driver No 70 0.13 411 58 0.141 0
MBL2 MBL2 P11226 Mannose-binding protein C chr10 GO:0031349 Not Cancer Driver No 63 0.254 122 32 0.262 0
MDK_ENST00000407067 MDK P21741 Midkine chr11 GO:0031349 Not Cancer Driver No 15 0.105 20 2 0.1 0
MED1 MED1 Q15648 Mediator of RNA polymerase II transcription subunit 1 chr17 GO:0031349 Not Cancer Driver No 162 0.102 1104 117 0.106 0
MEF2C_ENST00000504921 MEF2C Q06413 Myocyte-specific enhancer factor 2C chr5 GO:0031349 Not Cancer Driver No 92 0.195 408 81 0.199 0
MMP12 MMP12 P39900 Macrophage metalloelastase chr11 GO:0031349 Not Cancer Driver No 100 0.213 29 5 0.172 0
MMP8 MMP8 P22894 Neutrophil collagenase chr11 GO:0031349 Not Cancer Driver No 73 0.156 115 19 0.165 0
NECTIN2 NECTIN2 Q92692 Nectin-2 chr19 GO:0031349 Not Cancer Driver No 63 0.117 296 29 0.098 0
NLRC5_ENST00000436936 NLRC5 Q86WI3 Protein NLRC5 chr16 GO:0031349 Not Cancer Driver No 262 0.14 114 19 0.167 0
NLRP10 NLRP10 Q86W26 NACHT, LRR and PYD domains-containing protein 10 chr11 GO:0031349 Not Cancer Driver No 201 0.307 96 34 0.354 0
NOD1 NOD1 Q9Y239 Nucleotide-binding oligomerization domain-containing protein 1 chr7 GO:0031349 Not Cancer Driver No 130 0.136 38 7 0.184 0
NOD2 NOD2 Q9HC29 Nucleotide-binding oligomerization domain-containing protein 2 chr16 GO:0031349 Not Cancer Driver No 169 0.163 40 4 0.1 15
NPAS2 NPAS2 Q99743 Neuronal PAS domain-containing protein 2 chr2 GO:0031349 Not Cancer Driver No 114 0.138 465 65 0.14 0
NPY5R_ENST00000506953 NPY5R Q15761 Neuropeptide Y receptor type 5 chr4 GO:0031349 Not Cancer Driver No 144 0.324 44 16 0.364 0
NUPR1_ENST00000324873 NUPR1 O60356 Nuclear protein 1 chr16 GO:0031349 Not Cancer Driver No 10 0.122 82 10 0.122 0
OPTN_ENST00000263036 OPTN Q96CV9 Optineurin chr10 GO:0031349 Not Cancer Driver No 58 0.101 470 51 0.109 6
OSM OSM P13725 Oncostatin-M chr22 GO:0031349 Not Cancer Driver No 43 0.171 114 24 0.211 0
OSMR OSMR Q99650 Oncostatin-M-specific receptor subunit beta chr5 GO:0031349 Not Cancer Driver No 167 0.171 145 22 0.152 5
PAK1_ENST00000356341 PAK1 Q13153 Serine/threonine-protein kinase PAK 1 chr11 GO:0031349 Not Cancer Driver No 57 0.105 299 30 0.1 2
PAK2 PAK2 Q13177 Serine/threonine-protein kinase PAK 2 chr3 GO:0031349 Compendium Yes 89 0.17 242 49 0.202 0
PAK3_ENST00000262836 PAK3 O75914 Serine/threonine-protein kinase PAK 3 chrX GO:0031349 Not Cancer Driver No 127 0.227 286 64 0.224 2
PARK7_ENST00000377488 PARK7 Q99497 Parkinson disease protein 7 chr1 GO:0031349 Not Cancer Driver No 11 0.058 30 0 0.0 5
PARP9 PARP9 Q8IXQ6 Protein mono-ADP-ribosyltransferase PARP9 chr3 GO:0031349 Not Cancer Driver No 110 0.129 45 3 0.067 0
PENK_ENST00000451791 PENK P01210 Proenkephalin-A chr8 GO:0031349 Not Cancer Driver No 109 0.408 142 62 0.437 0
PGC PGC P20142 Gastricsin chr6 GO:0031349 Not Cancer Driver No 60 0.155 20 1 0.05 0
PIK3CG PIK3CG P48736 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform chr7 GO:0031349 Not Cancer Driver No 318 0.289 121 39 0.322 0
PLA2G3 PLA2G3 Q9NZ20 Group 3 secretory phospholipase A2 chr22 GO:0031349 Not Cancer Driver No 115 0.226 175 39 0.223 0
PLA2G5 PLA2G5 P39877 Phospholipase A2 group V chr1 GO:0031349 Not Cancer Driver No 24 0.174 0 0 0.0 2
PLCG2 PLCG2 P16885 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 chr16 GO:0031349 Not Cancer Driver No 248 0.196 142 30 0.211 1
PTGER3_ENST00000370931 PTGER3 P43115 Prostaglandin E2 receptor EP3 subtype chr1 GO:0031349 Not Cancer Driver No 79 0.203 17 2 0.118 0
PTGS2 PTGS2 P35354 Prostaglandin G/H synthase 2 chr1 GO:0031349 Not Cancer Driver No 105 0.174 30 5 0.167 0
PVR PVR P15151 Poliovirus receptor chr19 GO:0031349 Not Cancer Driver No 39 0.094 120 19 0.158 0
RAET1G RAET1G Q6H3X3 UL-16 binding protein 5 chr6 GO:0031349 Not Cancer Driver No 41 0.123 62 10 0.161 0
RIPK2 RIPK2 O43353 Receptor-interacting serine/threonine-protein kinase 2 chr8 GO:0031349 Not Cancer Driver No 63 0.117 143 20 0.14 0
RNF185 RNF185 Q96GF1 E3 ubiquitin-protein ligase RNF185 chr22 GO:0031349 Not Cancer Driver No 25 0.13 82 15 0.183 0
RNF31 RNF31 Q96EP0 E3 ubiquitin-protein ligase RNF31 chr14 GO:0031349 Not Cancer Driver No 142 0.132 319 45 0.141 0
RPS19_ENST00000600467 RPS19 P39019 40S ribosomal protein S19 chr19 GO:0031349 Not Cancer Driver No 15 0.103 61 3 0.049 23
SERPINE1 SERPINE1 P05121 Plasminogen activator inhibitor 1 chr7 GO:0031349 Not Cancer Driver No 78 0.194 7 2 0.286 0
SH2D1B SH2D1B O14796 SH2 domain-containing protein 1B chr1 GO:0031349 Not Cancer Driver No 34 0.258 0 0 0.0 0
SNX4 SNX4 O95219 Sorting nexin-4 chr3 GO:0031349 Not Cancer Driver No 31 0.069 101 5 0.05 0
SPI1_ENST00000378538 SPI1 P17947 Transcription factor PU.1 chr11 GO:0031349 Not Cancer Driver No 46 0.17 187 34 0.182 0
SRC_ENST00000358208 SRC P12931 Proto-oncogene tyrosine-protein kinase Src chr20 GO:0031349 Census Yes 53 0.099 130 11 0.085 1
STAP1_ENST00000396225 STAP1 Q9ULZ2 Signal-transducing adaptor protein 1 chr4 GO:0031349 Not Cancer Driver No 66 0.224 103 18 0.175 0
SYK_ENST00000375746 SYK P43405 Tyrosine-protein kinase SYK chr9 GO:0031349 Census Yes 96 0.151 131 27 0.206 5
TBK1 TBK1 Q9UHD2 Serine/threonine-protein kinase TBK1 chr12 GO:0031349 Not Cancer Driver No 101 0.139 42 5 0.119 12
TMEM173 STING1 Q86WV6 Stimulator of interferon genes protein chr5 GO:0031349 Not Cancer Driver No 46 0.121 66 13 0.197 3
TNF TNF P01375 Tumor necrosis factor chr6 GO:0031349 Not Cancer Driver No 24 0.103 45 3 0.067 0
TNFRSF11A TNFRSF11A Q9Y6Q6 Tumor necrosis factor receptor superfamily member 11A chr18 GO:0031349 Not Cancer Driver No 70 0.114 285 33 0.116 0
TNFSF11 TNFSF11 O14788 Tumor necrosis factor ligand superfamily member 11 chr13 GO:0031349 Not Cancer Driver No 52 0.164 56 1 0.018 1
TRAF6_ENST00000348124 TRAF6 Q9Y4K3 TNF receptor-associated factor 6 chr11 GO:0031349 Not Cancer Driver No 67 0.128 62 7 0.113 0
TREM2 TREM2 Q9NZC2 Triggering receptor expressed on myeloid cells 2 chr6 GO:0031349 Not Cancer Driver No 43 0.187 27 2 0.074 1
TRIM41 TRIM41 Q8WV44 E3 ubiquitin-protein ligase TRIM41 chr5 GO:0031349 Not Cancer Driver No 69 0.11 385 38 0.099 0
TRIM56 TRIM56 Q9BRZ2 E3 ubiquitin-protein ligase TRIM56 chr7 GO:0031349 Not Cancer Driver No 110 0.146 217 36 0.166 0
TRIM62 TRIM62 Q9BVG3 E3 ubiquitin-protein ligase TRIM62 chr1 GO:0031349 Not Cancer Driver No 58 0.122 80 14 0.175 0
TRIM6_ENST00000278302 TRIM6 Q9C030 Tripartite motif-containing protein 6 chr11 GO:0031349 Not Cancer Driver No 86 0.176 47 15 0.319 0
TTBK1 TTBK1 Q5TCY1 Tau-tubulin kinase 1 chr6 GO:0031349 Not Cancer Driver No 193 0.146 1045 154 0.147 0
TXK TXK P42681 Tyrosine-protein kinase TXK chr4 GO:0031349 Not Cancer Driver No 87 0.165 61 9 0.148 0
TYROBP TYROBP O43914 TYRO protein tyrosine kinase-binding protein chr19 GO:0031349 Not Cancer Driver No 24 0.212 28 8 0.286 0
UBE2K UBE2K P61086 Ubiquitin-conjugating enzyme E2 K chr4 GO:0031349 Not Cancer Driver No 24 0.12 33 3 0.091 0
UCN UCN P55089 Urocortin chr2 GO:0031349 Not Cancer Driver No 7 0.056 61 4 0.066 0
USP27X USP27X A6NNY8 Ubiquitin carboxyl-terminal hydrolase 27 chrX GO:0031349 Not Cancer Driver No 31 0.071 69 3 0.043 1
USP29_ENST00000598197 USP29 Q9HBJ7 Ubiquitin carboxyl-terminal hydrolase 29 chr19 GO:0031349 Not Cancer Driver No 291 0.316 432 132 0.306 0
VAMP7_ENST00000286448 VAMP7 P51809 Vesicle-associated membrane protein 7 chrX GO:0031349 Not Cancer Driver No 38 0.173 4 1 0.25 0
VAMP8 VAMP8 Q9BV40 Vesicle-associated membrane protein 8 chr2 GO:0031349 Not Cancer Driver No 9 0.09 27 0 0.0 0
WNT5A_ENST00000474267 WNT5A P41221 Protein Wnt-5a chr3 GO:0031349 Not Cancer Driver No 66 0.174 0 0 0.0 2
ZBP1 ZBP1 Q9H171 Z-DNA-binding protein 1 chr20 GO:0031349 Not Cancer Driver No 97 0.226 385 80 0.208 0
ZP3 ZP3 P21754 Zona pellucida sperm-binding protein 3 chr7 GO:0031349 Not Cancer Driver No 55 0.13 56 11 0.196 1