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Total number of protein in "GO:0010212" GO term:  140

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
ABCG5_ENST00000405322 ABCG5 Q9H222 ATP-binding cassette sub-family G member 5 chr2 GO:0010212 Not Cancer Driver No 77 0.118 43 8 0.186 6
ABRAXAS1 ABRAXAS1 Q6UWZ7 BRCA1-A complex subunit Abraxas 1 chr4 GO:0010212 Not Cancer Driver No 38 0.093 112 15 0.134 1
AEN AEN Q8WTP8 Apoptosis-enhancing nuclease chr15 GO:0010212 Not Cancer Driver No 39 0.12 183 21 0.115 0
ALAD ALAD P13716 Delta-aminolevulinic acid dehydratase chr9 GO:0010212 Not Cancer Driver No 52 0.158 13 3 0.231 5
ANXA1_ENST00000257497 ANXA1 P04083 Annexin A1 chr9 GO:0010212 Not Cancer Driver No 59 0.171 61 12 0.197 0
APOBEC1 APOBEC1 P41238 C->U-editing enzyme APOBEC-1 chr12 GO:0010212 Not Cancer Driver No 62 0.263 13 1 0.077 0
ATM_ENST00000452508 ATM Q13315 Serine-protein kinase ATM chr11 GO:0010212 Census, Compendium Yes 469 0.153 225 39 0.173 41
ATR ATR Q13535 Serine/threonine-protein kinase ATR chr3 GO:0010212 Census, Compendium Yes 338 0.128 106 14 0.132 1
BABAM1_ENST00000601043 BABAM1 Q9NWV8 BRISC and BRCA1-A complex member 1 chr19 GO:0010212 Not Cancer Driver No 35 0.106 113 14 0.124 0
BABAM2_ENST00000342045 BABAM2 Q9NXR7 BRISC and BRCA1-A complex member 2 chr2 GO:0010212 Not Cancer Driver No 52 0.136 0 0 0.0 0
BAK1 BAK1 Q16611 Bcl-2 homologous antagonist/killer chr6 GO:0010212 Not Cancer Driver No 38 0.18 58 9 0.155 0
BARD1 BARD1 Q99728 BRCA1-associated RING domain protein 1 chr2 GO:0010212 Census Yes 96 0.124 384 49 0.128 0
BAX_ENST00000345358 BAX Q07812 Apoptosis regulator BAX chr19 GO:0010212 Census Yes 30 0.156 39 2 0.051 0
BCL2L1 BCL2L1 Q07817 Bcl-2-like protein 1 chr20 GO:0010212 Not Cancer Driver No 29 0.124 55 3 0.055 0
BCL2_ENST00000333681 BCL2 P10415 Apoptosis regulator Bcl-2 chr18 GO:0010212 Census, Compendium Yes 24 0.1 72 5 0.069 0
BLM BLM P54132 Bloom syndrome protein chr15 GO:0010212 Census Yes 153 0.108 667 70 0.105 8
BRAT1 BRAT1 Q6PJG6 BRCA1-associated ATM activator 1 chr7 GO:0010212 Not Cancer Driver No 112 0.136 101 13 0.129 0
BRCA1_ENST00000357654 BRCA1 P38398 Breast cancer type 1 susceptibility protein chr17 GO:0010212 Census, Compendium Yes 224 0.12 1458 174 0.119 35
BRCA2_ENST00000544455 BRCA2 P51587 Breast cancer type 2 susceptibility protein chr13 GO:0010212 Census, Compendium Yes 457 0.134 1542 225 0.146 46
BRCC3 BRCC3 P46736 Lys-63-specific deubiquitinase BRCC36 chrX GO:0010212 Not Cancer Driver No 39 0.123 74 7 0.095 0
BRSK1 BRSK1 Q8TDC3 Serine/threonine-protein kinase BRSK1 chr19 GO:0010212 Not Cancer Driver No 131 0.168 459 78 0.17 0
CASP3 CASP3 P42574 Caspase-3 chr4 GO:0010212 Census Yes 32 0.116 62 5 0.081 0
CBL CBL P22681 E3 ubiquitin-protein ligase CBL chr11 GO:0010212 Census, Compendium Yes 115 0.127 512 56 0.109 4
CCND1 CCND1 P24385 G1/S-specific cyclin-D1 chr11 GO:0010212 Census, Compendium Yes 55 0.186 31 25 0.806 0
CDKN1A_ENST00000373711 CDKN1A P38936 Cyclin-dependent kinase inhibitor 1 chr6 GO:0010212 Census, Compendium Yes 48 0.293 121 30 0.248 0
CHEK2_ENST00000405598 CHEK2 O96017 Serine/threonine-protein kinase Chk2 chr22 GO:0010212 Census, Compendium Yes 335 0.617 157 130 0.828 13
CLK2 CLK2 P49760 Dual specificity protein kinase CLK2 chr1 GO:0010212 Not Cancer Driver No 104 0.208 151 37 0.245 0
CLOCK CLOCK O15516 Circadian locomoter output cycles protein kaput chr4 GO:0010212 Not Cancer Driver No 83 0.098 458 38 0.083 0
COP1 COP1 Q8NHY2 E3 ubiquitin-protein ligase COP1 chr1 GO:0010212 Not Cancer Driver No 106 0.145 147 11 0.075 0
CRYAB_ENST00000616970 CRYAB P02511 Alpha-crystallin B chain chr11 GO:0010212 Not Cancer Driver No 22 0.126 59 11 0.186 4
CXCL10 CXCL10 P02778 C-X-C motif chemokine 10 chr4 GO:0010212 Not Cancer Driver No 19 0.194 12 4 0.333 0
CYBA CYBA P13498 Cytochrome b-245 light chain chr16 GO:0010212 Not Cancer Driver No 26 0.133 66 2 0.03 12
DCLRE1C DCLRE1C Q96SD1 Protein artemis chr10 GO:0010212 Not Cancer Driver No 76 0.11 277 26 0.094 3
DCUN1D3 DCUN1D3 Q8IWE4 DCN1-like protein 3 chr16 GO:0010212 Not Cancer Driver No 36 0.118 118 9 0.076 0
DNM2_ENST00000355667 DNM2 P50570 Dynamin-2 chr19 GO:0010212 Census Yes 138 0.159 270 43 0.159 22
DNMT3A DNMT3A Q9Y6K1 DNA (cytosine-5)-methyltransferase 3A chr2 GO:0010212 Census, Compendium Yes 194 0.213 371 59 0.159 16
ECT2 ECT2 Q9H8V3 Protein ECT2 chr3 GO:0010212 Not Cancer Driver No 104 0.114 284 33 0.116 0
EEF1D_ENST00000395119 EEF1D P29692 Elongation factor 1-delta chr8 GO:0010212 Not Cancer Driver No 40 0.142 153 22 0.144 0
EGR1 EGR1 P18146 Early growth response protein 1 chr5 GO:0010212 Not Cancer Driver No 78 0.144 501 72 0.144 0
ELK1_ENST00000376983 ELK1 P19419 ETS domain-containing protein Elk-1 chrX GO:0010212 Not Cancer Driver No 51 0.119 327 34 0.104 0
ERCC1_ENST00000589165 ERCC1 P07992 DNA excision repair protein ERCC-1 chr19 GO:0010212 Not Cancer Driver No 42 0.141 105 14 0.133 1
ERCC6 ERCC6 Q03468 DNA excision repair protein ERCC-6 chr10 GO:0010212 Not Cancer Driver No 211 0.141 829 117 0.141 9
ERCC8 ERCC8 Q13216 DNA excision repair protein ERCC-8 chr5 GO:0010212 Not Cancer Driver No 25 0.063 53 8 0.151 7
EYA1_ENST00000647540 EYA1 Q99502 Eyes absent homolog 1 chr8 GO:0010212 Not Cancer Driver No 168 0.284 341 99 0.29 15
EYA3 EYA3 Q99504 Eyes absent homolog 3 chr1 GO:0010212 Not Cancer Driver No 58 0.101 310 40 0.129 0
FANCD2_ENST00000383807 FANCD2 Q9BXW9 Fanconi anemia group D2 protein chr3 GO:0010212 Census, Compendium Yes 176 0.121 181 14 0.077 3
FBXO4 FBXO4 Q9UKT5 F-box only protein 4 chr5 GO:0010212 Not Cancer Driver No 55 0.142 68 7 0.103 0
FIGNL1 FIGNL1 Q6PIW4 Fidgetin-like protein 1 chr7 GO:0010212 Not Cancer Driver No 75 0.111 224 23 0.103 0
GADD45A GADD45A P24522 Growth arrest and DNA damage-inducible protein GADD45 alpha chr1 GO:0010212 Not Cancer Driver No 10 0.061 39 5 0.128 0
GATA3_ENST00000346208 GATA3 P23771 Trans-acting T-cell-specific transcription factor GATA-3 chr10 GO:0010212 Census, Compendium Yes 111 0.251 364 87 0.239 2
GPX1_ENST00000620890 GPX1 P07203 Glutathione peroxidase 1 chr3 GO:0010212 Not Cancer Driver No 38 0.187 12 1 0.083 0
GRB2_ENST00000392564 GRB2 P62993 Growth factor receptor-bound protein 2 chr17 GO:0010212 Not Cancer Driver No 28 0.129 10 1 0.1 0
GTF2H5 GTF2H5 Q6ZYL4 General transcription factor IIH subunit 5 chr6 GO:0010212 Not Cancer Driver No 7 0.099 0 0 0.0 1
H2AFX H2AX P16104 Histone H2AX chr11 GO:0010212 Not Cancer Driver No 20 0.14 68 10 0.147 0
HAMP_ENST00000222304 HAMP P81172 Hepcidin chr19 GO:0010212 Not Cancer Driver No 7 0.083 4 0 0.0 4
HRAS HRAS P01112 GTPase HRas chr11 GO:0010212 Census, Compendium Yes 107 0.566 16 4 0.25 18
HSF1 HSF1 Q00613 Heat shock factor protein 1 chr8 GO:0010212 Not Cancer Driver No 59 0.112 335 37 0.11 0
HSPA5 HSPA5 P11021 Endoplasmic reticulum chaperone BiP chr9 GO:0010212 Not Cancer Driver No 73 0.112 282 35 0.124 0
HUS1 HUS1 O60921 Checkpoint protein HUS1 chr7 GO:0010212 Not Cancer Driver No 25 0.089 17 2 0.118 0
IFI16_ENST00000295809 IFI16 Q16666 Gamma-interferon-inducible protein 16 chr1 GO:0010212 Not Cancer Driver No 155 0.197 419 90 0.215 0
IKBIP_ENST00000342502 IKBIP Q70UQ0 Inhibitor of nuclear factor kappa-B kinase-interacting protein chr12 GO:0010212 Not Cancer Driver No 53 0.151 69 8 0.116 0
IL1A IL1A P01583 Interleukin-1 alpha chr2 GO:0010212 Not Cancer Driver No 30 0.111 35 6 0.171 0
INIP INIP Q9NRY2 SOSS complex subunit C chr9 GO:0010212 Not Cancer Driver No 25 0.24 79 16 0.203 0
INO80_ENST00000401393 INO80 Q9ULG1 Chromatin-remodeling ATPase INO80 chr15 GO:0010212 Compendium Yes 173 0.111 682 76 0.111 0
INTS3_ENST00000435409 INTS3 Q68E01 Integrator complex subunit 3 chr1 GO:0010212 Not Cancer Driver No 125 0.12 213 25 0.117 0
INTS7 INTS7 Q9NVH2 Integrator complex subunit 7 chr1 GO:0010212 Not Cancer Driver No 106 0.11 88 17 0.193 0
ITGB6_ENST00000409872 ITGB6 P18564 Integrin beta-6 chr2 GO:0010212 Not Cancer Driver No 120 0.152 26 4 0.154 3
KARS_ENST00000302445 KARS1 Q15046 Lysine--tRNA ligase chr16 GO:0010212 Not Cancer Driver No 88 0.147 160 15 0.094 12
KAT5_ENST00000377046 KAT5 Q92993 Histone acetyltransferase KAT5 chr11 GO:0010212 Not Cancer Driver No 65 0.127 173 21 0.121 3
KDM1A_ENST00000356634 KDM1A O60341 Lysine-specific histone demethylase 1A chr1 GO:0010212 Not Cancer Driver No 67 0.079 291 28 0.096 3
KDM4D_ENST00000610872 KDM4D Q6B0I6 Lysine-specific demethylase 4D chr11 GO:0010212 Not Cancer Driver No 78 0.149 215 33 0.153 0
LIG4 LIG4 P49917 DNA ligase 4 chr13 GO:0010212 Not Cancer Driver No 134 0.147 63 10 0.159 2
MAP3K20 MAP3K20 Q9NYL2 Mitogen-activated protein kinase kinase kinase 20 chr2 GO:0010212 Not Cancer Driver No 101 0.126 294 41 0.139 1
MAPK14_ENST00000229794 MAPK14 Q16539 Mitogen-activated protein kinase 14 chr6 GO:0010212 Not Cancer Driver No 39 0.108 25 1 0.04 0
MDM2_ENST00000539479 MDM2 Q00987 E3 ubiquitin-protein ligase Mdm2 chr12 GO:0010212 Census, Compendium Yes 56 0.114 297 37 0.125 0
MEN1 MEN1 O00255 Menin chr11 GO:0010212 Census, Compendium Yes 73 0.119 228 15 0.066 90
MRNIP MRNIP Q6NTE8 MRN complex-interacting protein chr5 GO:0010212 Not Cancer Driver No 44 0.128 268 35 0.131 0
MSH2 MSH2 P43246 DNA mismatch repair protein Msh2 chr2 GO:0010212 Census Yes 92 0.099 37 4 0.108 70
MTA1 MTA1 Q13330 Metastasis-associated protein MTA1 chr14 GO:0010212 Not Cancer Driver No 92 0.129 327 42 0.128 0
MYC_ENST00000377970 MYC P01106 Myc proto-oncogene protein chr8 GO:0010212 Census, Compendium Yes 80 0.182 299 46 0.154 0
NABP1 NABP1 Q96AH0 SOSS complex subunit B2 chr2 GO:0010212 Not Cancer Driver No 25 0.123 102 11 0.108 0
NABP2_ENST00000341463 NABP2 Q9BQ15 SOSS complex subunit B1 chr12 GO:0010212 Not Cancer Driver No 25 0.118 125 17 0.136 0
NET1 NET1 Q7Z628 Neuroepithelial cell-transforming gene 1 protein chr10 GO:0010212 Not Cancer Driver No 60 0.101 294 37 0.126 0
NHEJ1 NHEJ1 Q9H9Q4 Non-homologous end-joining factor 1 chr2 GO:0010212 Not Cancer Driver No 35 0.117 83 8 0.096 2
NIPBL NIPBL Q6KC79 Nipped-B-like protein chr5 GO:0010212 Compendium Yes 353 0.126 1528 184 0.12 37
NUCKS1 NUCKS1 Q9H1E3 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 chr1 GO:0010212 Not Cancer Driver No 30 0.123 243 30 0.123 0
PARP1 PARP1 P09874 Poly [ADP-ribose] polymerase 1 chr1 GO:0010212 Not Cancer Driver No 119 0.117 320 34 0.106 0
PAXIP1 PAXIP1 Q6ZW49 PAX-interacting protein 1 chr7 GO:0010212 Not Cancer Driver No 120 0.112 461 39 0.085 0
PML PML P29590 Protein PML chr15 GO:0010212 Census, Compendium Yes 112 0.127 312 34 0.109 0
POLB POLB P06746 DNA polymerase beta chr8 GO:0010212 Not Cancer Driver No 43 0.128 87 11 0.126 0
PRAP1 PRAP1 Q96NZ9 Proline-rich acidic protein 1 chr10 GO:0010212 Not Cancer Driver No 14 0.093 124 13 0.105 0
PRKAA1_ENST00000397128 PRKAA1 Q13131 5'-AMP-activated protein kinase catalytic subunit alpha-1 chr5 GO:0010212 Not Cancer Driver No 72 0.129 124 17 0.137 0
PRKDC PRKDC P78527 DNA-dependent protein kinase catalytic subunit chr8 GO:0010212 Not Cancer Driver No 538 0.13 421 61 0.145 2
PTPRC PTPRC P08575 Receptor-type tyrosine-protein phosphatase C chr1 GO:0010212 Census, Compendium Yes 315 0.241 462 107 0.232 0
RAD1 RAD1 O60671 Cell cycle checkpoint protein RAD1 chr5 GO:0010212 Not Cancer Driver No 29 0.103 4 1 0.25 0
RAD51AP1 RAD51AP1 Q96B01 RAD51-associated protein 1 chr12 GO:0010212 Not Cancer Driver No 46 0.131 335 43 0.128 0
RAD51_ENST00000267868 RAD51 Q06609 DNA repair protein RAD51 homolog 1 chr15 GO:0010212 Not Cancer Driver No 42 0.124 47 5 0.106 3
RAD54B RAD54B Q9Y620 DNA repair and recombination protein RAD54B chr8 GO:0010212 Not Cancer Driver No 112 0.123 120 16 0.133 0
RAD54L_ENST00000442598 RAD54L Q92698 DNA repair and recombination protein RAD54-like chr1 GO:0010212 Not Cancer Driver No 79 0.106 124 13 0.105 0
RAD9A RAD9A Q99638 Cell cycle checkpoint control protein RAD9A chr11 GO:0010212 Not Cancer Driver No 34 0.087 135 7 0.052 0
RAD9B RAD9B Q6WBX8 Cell cycle checkpoint control protein RAD9B chr12 GO:0010212 Not Cancer Driver No 46 0.108 40 6 0.15 0
RFWD3 RFWD3 Q6PCD5 E3 ubiquitin-protein ligase RFWD3 chr16 GO:0010212 Census Yes 68 0.088 318 30 0.094 1
RHNO1 RHNO1 Q9BSD3 RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 chr12 GO:0010212 Not Cancer Driver No 26 0.109 193 21 0.109 0
RHOB RHOB P62745 Rho-related GTP-binding protein RhoB chr2 GO:0010212 Not Cancer Driver No 52 0.265 19 2 0.105 0
RNF168 RNF168 Q8IYW5 E3 ubiquitin-protein ligase RNF168 chr3 GO:0010212 Not Cancer Driver No 77 0.135 471 66 0.14 0
RNF8 RNF8 O76064 E3 ubiquitin-protein ligase RNF8 chr6 GO:0010212 Not Cancer Driver No 56 0.115 226 29 0.128 0
RPL26 RPL26 P61254 60S ribosomal protein L26 chr17 GO:0010212 Not Cancer Driver No 16 0.11 114 13 0.114 0
SFRP1 SFRP1 Q8N474 Secreted frizzled-related protein 1 chr8 GO:0010212 Not Cancer Driver No 40 0.127 39 7 0.179 0
SFRP2 SFRP2 Q96HF1 Secreted frizzled-related protein 2 chr4 GO:0010212 Not Cancer Driver No 47 0.159 1 0 0.0 0
SIRT1 SIRT1 Q96EB6 NAD-dependent protein deacetylase sirtuin-1 chr10 GO:0010212 Not Cancer Driver No 70 0.094 435 31 0.071 0
SMPD1 SMPD1 P17405 Sphingomyelin phosphodiesterase chr11 GO:0010212 Not Cancer Driver No 93 0.147 51 4 0.078 111
SNAI2_ENST00000020945 SNAI2 O43623 Zinc finger protein SNAI2 chr8 GO:0010212 Not Cancer Driver No 52 0.194 52 9 0.173 0
SOD2_ENST00000367055 SOD2 P04179 Superoxide dismutase [Mn], mitochondrial chr6 GO:0010212 Not Cancer Driver No 32 0.144 25 5 0.2 0
SPIDR SPIDR Q14159 DNA repair-scaffolding protein chr8 GO:0010212 Not Cancer Driver No 101 0.11 329 20 0.061 0
STK11 STK11 Q15831 Serine/threonine-protein kinase STK11 chr19 GO:0010212 Census, Compendium Yes 75 0.173 135 14 0.104 9
SWI5 SWI5 Q1ZZU3 DNA repair protein SWI5 homolog chr9 GO:0010212 Not Cancer Driver No 45 0.191 128 35 0.273 0
TANK TANK Q92844 TRAF family member-associated NF-kappa-B activator chr2 GO:0010212 Not Cancer Driver No 42 0.099 302 26 0.086 0
THBD THBD P07204 Thrombomodulin chr20 GO:0010212 Not Cancer Driver No 39 0.068 51 3 0.059 9
TICRR TICRR Q7Z2Z1 Treslin chr15 GO:0010212 Not Cancer Driver No 201 0.105 1308 129 0.099 0
TIGAR TIGAR Q9NQ88 Fructose-2,6-bisphosphatase TIGAR chr12 GO:0010212 Not Cancer Driver No 44 0.163 39 9 0.231 0
TLK2 TLK2 Q86UE8 Serine/threonine-protein kinase tousled-like 2 chr17 GO:0010212 Not Cancer Driver No 120 0.155 436 58 0.133 5
TMEM109 TMEM109 Q9BVC6 Transmembrane protein 109 chr11 GO:0010212 Not Cancer Driver No 39 0.16 7 0 0.0 0
TNKS1BP1 TNKS1BP1 Q9C0C2 182 kDa tankyrase-1-binding protein chr11 GO:0010212 Not Cancer Driver No 221 0.128 1712 219 0.128 0
TOPBP1 TOPBP1 Q92547 DNA topoisomerase 2-binding protein 1 chr3 GO:0010212 Not Cancer Driver No 169 0.111 577 59 0.102 0
TP53BP1_ENST00000263801 TP53BP1 Q12888 TP53-binding protein 1 chr15 GO:0010212 Not Cancer Driver No 227 0.115 1632 190 0.116 0
TP53_ENST00000445888 TP53 P04637 Cellular tumor antigen p53 chr17 GO:0010212 Census, Compendium Yes 2891 7.356 282 1466 5.199 83
TREX1_ENST00000625293 TREX1 Q9NSU2 Three-prime repair exonuclease 1 chr3 GO:0010212 Not Cancer Driver No 26 0.083 98 10 0.102 18
TRIM13_ENST00000378182 TRIM13 O60858 E3 ubiquitin-protein ligase TRIM13 chr13 GO:0010212 Not Cancer Driver No 53 0.13 1 0 0.0 0
TSPYL5 TSPYL5 Q86VY4 Testis-specific Y-encoded-like protein 5 chr8 GO:0010212 Not Cancer Driver No 92 0.221 257 61 0.237 0
UIMC1_ENST00000511320 UIMC1 Q96RL1 BRCA1-A complex subunit RAP80 chr5 GO:0010212 Not Cancer Driver No 64 0.089 609 51 0.084 0
USP28 USP28 Q96RU2 Ubiquitin carboxyl-terminal hydrolase 28 chr11 GO:0010212 Not Cancer Driver No 151 0.14 311 25 0.08 0
VCAM1 VCAM1 P19320 Vascular cell adhesion protein 1 chr1 GO:0010212 Not Cancer Driver No 188 0.254 110 28 0.255 0
WRN WRN Q14191 Werner syndrome ATP-dependent helicase chr8 GO:0010212 Census, Compendium Yes 164 0.115 373 41 0.11 2
XRCC2 XRCC2 O43543 DNA repair protein XRCC2 chr7 GO:0010212 Not Cancer Driver No 36 0.129 9 1 0.111 2
XRCC4 XRCC4 Q13426 DNA repair protein XRCC4 chr5 GO:0010212 Not Cancer Driver No 47 0.14 171 31 0.181 3
XRCC5_ENST00000392132 XRCC5 P13010 X-ray repair cross-complementing protein 5 chr2 GO:0010212 Not Cancer Driver No 87 0.119 118 11 0.093 0
XRCC6 XRCC6 P12956 X-ray repair cross-complementing protein 6 chr22 GO:0010212 Not Cancer Driver No 66 0.108 140 12 0.086 0
XRRA1 XRRA1 Q6P2D8 X-ray radiation resistance-associated protein 1 chr11 GO:0010212 Not Cancer Driver No 86 0.109 316 31 0.098 0
YAP1_ENST00000282441 YAP1 P46937 Transcriptional coactivator YAP1 chr11 GO:0010212 Not Cancer Driver No 51 0.101 489 49 0.1 0
ZMPSTE24 ZMPSTE24 O75844 CAAX prenyl protease 1 homolog chr1 GO:0010212 Not Cancer Driver No 67 0.141 23 0 0.0 3