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Total number of protein in "GO:0007167" GO term:  252

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
ABL1_ENST00000318560 ABL1 P00519 Tyrosine-protein kinase ABL1 chr9 GO:0007167 Census, Compendium Yes 139 0.123 604 73 0.121 2
ACVR1B_ENST00000257963 ACVR1B P36896 Activin receptor type-1B chr12 GO:0007167 Census Yes 114 0.226 0 0 0.0 0
ACVR1C ACVR1C Q8NER5 Activin receptor type-1C chr2 GO:0007167 Not Cancer Driver No 90 0.183 3 1 0.333 0
ACVR1_ENST00000434821 ACVR1 Q04771 Activin receptor type-1 chr2 GO:0007167 Census, Compendium Yes 78 0.153 21 8 0.381 8
AKT1S1_ENST00000391834 AKT1S1 Q96B36 Proline-rich AKT1 substrate 1 chr19 GO:0007167 Not Cancer Driver No 23 0.09 256 23 0.09 0
AKT1_ENST00000349310 AKT1 P31749 RAC-alpha serine/threonine-protein kinase chr14 GO:0007167 Census, Compendium Yes 108 0.225 158 24 0.152 4
ANGPT1 ANGPT1 Q15389 Angiopoietin-1 chr8 GO:0007167 Not Cancer Driver No 130 0.261 131 24 0.183 1
ANGPT2 ANGPT2 O15123 Angiopoietin-2 chr8 GO:0007167 Not Cancer Driver No 63 0.127 96 10 0.104 1
ANKS1A ANKS1A Q92625 Ankyrin repeat and SAM domain-containing protein 1A chr6 GO:0007167 Not Cancer Driver No 120 0.106 756 75 0.099 0
ANKS1B ANKS1B Q7Z6G8 Ankyrin repeat and sterile alpha motif domain-containing protein 1B chr12 GO:0007167 Not Cancer Driver No 254 0.204 659 150 0.228 0
ARHGEF28_ENST00000426542 ARHGEF28 Q8N1W1 Rho guanine nucleotide exchange factor 28 chr5 GO:0007167 Not Cancer Driver No 188 0.11 764 88 0.115 0
ARHGEF7 ARHGEF7 Q14155 Rho guanine nucleotide exchange factor 7 chr13 GO:0007167 Not Cancer Driver No 106 0.132 301 39 0.13 0
ARID5B ARID5B Q14865 AT-rich interactive domain-containing protein 5B chr10 GO:0007167 Not Cancer Driver No 162 0.136 769 95 0.124 0
AXL AXL P30530 Tyrosine-protein kinase receptor UFO chr19 GO:0007167 Not Cancer Driver No 168 0.188 341 64 0.188 0
BCAR1_ENST00000162330 BCAR1 P56945 Breast cancer anti-estrogen resistance protein 1 chr16 GO:0007167 Not Cancer Driver No 108 0.124 677 75 0.111 0
BDNF_ENST00000439476 BDNF P23560 Brain-derived neurotrophic factor chr11 GO:0007167 Not Cancer Driver No 47 0.19 79 19 0.241 1
BMP2 BMP2 P12643 Bone morphogenetic protein 2 chr20 GO:0007167 Not Cancer Driver No 73 0.184 139 26 0.187 0
BMP4 BMP4 P12644 Bone morphogenetic protein 4 chr14 GO:0007167 Not Cancer Driver No 86 0.211 142 26 0.183 5
BMPR1A BMPR1A P36894 Bone morphogenetic protein receptor type-1A chr10 GO:0007167 Census, Compendium Yes 66 0.124 21 0 0.0 8
C2CD5_ENST00000333957 C2CD5 Q86YS7 C2 domain-containing protein 5 chr12 GO:0007167 Not Cancer Driver No 136 0.136 250 40 0.16 0
CASP3 CASP3 P42574 Caspase-3 chr4 GO:0007167 Census Yes 32 0.116 62 5 0.081 0
CD4 CD4 P01730 T-cell surface glycoprotein CD4 chr12 GO:0007167 Not Cancer Driver No 69 0.151 56 11 0.196 0
CDK5R1 CDK5R1 Q15078 Cyclin-dependent kinase 5 activator 1 chr17 GO:0007167 Not Cancer Driver No 35 0.114 103 16 0.155 0
CFC1 CFC1 P0CG37 Cryptic protein chr2 GO:0007167 Not Cancer Driver No 25 0.112 68 23 0.338 1
CFC1B CFC1B P0CG36 Cryptic family protein 1B chr2 GO:0007167 Not Cancer Driver No 2 0.009 55 1 0.018 0
CHN1 CHN1 P15882 N-chimaerin chr2 GO:0007167 Not Cancer Driver No 69 0.15 44 9 0.205 7
CHRD CHRD Q9H2X0 Chordin chr3 GO:0007167 Not Cancer Driver No 171 0.179 308 61 0.198 0
CITED2_ENST00000367651 CITED2 Q99967 Cbp/p300-interacting transactivator 2 chr6 GO:0007167 Not Cancer Driver No 23 0.085 230 18 0.078 0
CLEC14A CLEC14A Q86T13 C-type lectin domain family 14 member A chr14 GO:0007167 Not Cancer Driver No 147 0.3 182 60 0.33 0
COL1A1 COL1A1 P02452 Collagen alpha-1(I) chain chr17 GO:0007167 Census, Compendium Yes 247 0.169 1212 214 0.177 148
COL4A1 COL4A1 P02462 Collagen alpha-1(IV) chain chr13 GO:0007167 Not Cancer Driver No 349 0.209 1457 310 0.213 32
COL4A2 COL4A2 P08572 Collagen alpha-2(IV) chain chr13 GO:0007167 Not Cancer Driver No 264 0.154 1462 234 0.16 2
COL4A3 COL4A3 Q01955 Collagen alpha-3(IV) chain chr2 GO:0007167 Not Cancer Driver No 310 0.186 1433 277 0.193 13
COL4A5_ENST00000361603 COL4A5 P29400 Collagen alpha-5(IV) chain chrX GO:0007167 Not Cancer Driver No 378 0.224 1459 327 0.224 144
COL4A6_ENST00000372216 COL4A6 Q14031 Collagen alpha-6(IV) chain chrX GO:0007167 Not Cancer Driver No 286 0.169 1451 255 0.176 1
CPNE3 CPNE3 O75131 Copine-3 chr8 GO:0007167 Not Cancer Driver No 79 0.147 33 5 0.152 0
CRIM1 CRIM1 Q9NZV1 Cysteine-rich motor neuron 1 protein chr2 GO:0007167 Not Cancer Driver No 133 0.128 35 4 0.114 0
CRK CRK P46108 Adapter molecule crk chr17 GO:0007167 Not Cancer Driver No 30 0.099 197 23 0.117 0
CRLF2_ENST00000381566 CRLF2 Q9HC73 Cytokine receptor-like factor 2 chrX GO:0007167 Census Yes 54 0.146 62 3 0.048 0
CSH1 CSH1 P0DML2 Chorionic somatomammotropin hormone 1 chr17 GO:0007167 Not Cancer Driver No 33 0.152 23 2 0.087 0
CSH2 CSH2 P0DML3 Chorionic somatomammotropin hormone 2 chr17 GO:0007167 Not Cancer Driver No 53 0.244 23 3 0.13 0
CSHL1 CSHL1 Q14406 Chorionic somatomammotropin hormone-like 1 chr17 GO:0007167 Not Cancer Driver No 63 0.284 18 5 0.278 0
CSPG4 CSPG4 Q6UVK1 Chondroitin sulfate proteoglycan 4 chr15 GO:0007167 Not Cancer Driver No 259 0.112 838 85 0.101 0
CSRNP1 CSRNP1 Q96S65 Cysteine/serine-rich nuclear protein 1 chr3 GO:0007167 Not Cancer Driver No 71 0.121 312 33 0.106 0
CTF1 CTF1 Q16619 Cardiotrophin-1 chr16 GO:0007167 Not Cancer Driver No 6 0.03 90 4 0.044 0
CUL5 CUL5 Q93034 Cullin-5 chr11 GO:0007167 Not Cancer Driver No 97 0.124 5 1 0.2 0
DAB2IP_ENST00000408936 DAB2IP Q5VWQ8 Disabled homolog 2-interacting protein chr9 GO:0007167 Not Cancer Driver No 131 0.11 681 68 0.1 0
DDIT4 DDIT4 Q9NX09 DNA damage-inducible transcript 4 protein chr10 GO:0007167 Not Cancer Driver No 20 0.086 87 9 0.103 0
DDR1_ENST00000324771 DDR1 Q08345 Epithelial discoidin domain-containing receptor 1 chr6 GO:0007167 Not Cancer Driver No 123 0.135 253 49 0.194 0
DDR2 DDR2 Q16832 Discoidin domain-containing receptor 2 chr1 GO:0007167 Census Yes 192 0.225 118 34 0.288 7
EFNA1 EFNA1 P20827 Ephrin-A1 chr1 GO:0007167 Not Cancer Driver No 29 0.141 46 5 0.109 0
EFNA2 EFNA2 O43921 Ephrin-A2 chr19 GO:0007167 Not Cancer Driver No 16 0.075 13 2 0.154 0
EFNA3 EFNA3 P52797 Ephrin-A3 chr1 GO:0007167 Not Cancer Driver No 24 0.101 31 11 0.355 0
EFNA4_ENST00000368409 EFNA4 P52798 Ephrin-A4 chr1 GO:0007167 Not Cancer Driver No 28 0.139 17 3 0.176 0
EFNA5 EFNA5 P52803 Ephrin-A5 chr5 GO:0007167 Not Cancer Driver No 34 0.149 25 6 0.24 0
EFNB1 EFNB1 P98172 Ephrin-B1 chrX GO:0007167 Not Cancer Driver No 46 0.133 126 14 0.111 19
EFNB2_ENST00000245323 EFNB2 P52799 Ephrin-B2 chr13 GO:0007167 Not Cancer Driver No 42 0.126 97 15 0.155 0
EFNB3 EFNB3 Q15768 Ephrin-B3 chr17 GO:0007167 Not Cancer Driver No 45 0.132 183 22 0.12 0
EGF EGF P01133 Pro-epidermal growth factor chr4 GO:0007167 Not Cancer Driver No 184 0.152 191 25 0.131 1
EIF2AK3 EIF2AK3 Q9NZJ5 Eukaryotic translation initiation factor 2-alpha kinase 3 chr2 GO:0007167 Not Cancer Driver No 149 0.134 410 51 0.124 1
EPHA1 EPHA1 P21709 Ephrin type-A receptor 1 chr7 GO:0007167 Not Cancer Driver No 147 0.151 211 38 0.18 0
EPHA10 EPHA10 Q5JZY3 Ephrin type-A receptor 10 chr1 GO:0007167 Not Cancer Driver No 171 0.17 225 41 0.182 0
EPHA2 EPHA2 P29317 Ephrin type-A receptor 2 chr1 GO:0007167 Compendium Yes 171 0.175 187 39 0.209 3
EPHA3 EPHA3 P29320 Ephrin type-A receptor 3 chr3 GO:0007167 Census, Compendium Yes 346 0.352 74 28 0.378 0
EPHA4_ENST00000409938 EPHA4 P54764 Ephrin type-A receptor 4 chr2 GO:0007167 Not Cancer Driver No 182 0.185 140 24 0.171 0
EPHA5_ENST00000273854 EPHA5 P54756 Ephrin type-A receptor 5 chr4 GO:0007167 Not Cancer Driver No 341 0.329 83 39 0.47 0
EPHA7 EPHA7 Q15375 Ephrin type-A receptor 7 chr6 GO:0007167 Census, Compendium Yes 280 0.281 71 15 0.211 0
EPHA8 EPHA8 P29322 Ephrin type-A receptor 8 chr1 GO:0007167 Not Cancer Driver No 197 0.196 121 17 0.14 0
EPHB1 EPHB1 P54762 Ephrin type-B receptor 1 chr3 GO:0007167 Not Cancer Driver No 316 0.321 67 17 0.254 0
EPHB2 EPHB2 P29323 Ephrin type-B receptor 2 chr1 GO:0007167 Not Cancer Driver No 186 0.176 119 17 0.143 7
EPHB3 EPHB3 P54753 Ephrin type-B receptor 3 chr3 GO:0007167 Not Cancer Driver No 155 0.155 137 16 0.117 0
EPHB4 EPHB4 P54760 Ephrin type-B receptor 4 chr7 GO:0007167 Not Cancer Driver No 125 0.127 184 19 0.103 11
EPHB6_ENST00000422643 EPHB6 O15197 Ephrin type-B receptor 6 chr7 GO:0007167 Not Cancer Driver No 227 0.222 246 45 0.183 0
ERBB2 ERBB2 P04626 Receptor tyrosine-protein kinase erbB-2 chr17 GO:0007167 Census, Compendium Yes 275 0.219 314 41 0.131 1
ETV2_ENST00000403402 ETV2 O00321 ETS translocation variant 2 chr19 GO:0007167 Not Cancer Driver No 23 0.067 227 15 0.066 0
FER FER P16591 Tyrosine-protein kinase Fer chr5 GO:0007167 Not Cancer Driver No 114 0.139 145 21 0.145 0
FGF10 FGF10 O15520 Fibroblast growth factor 10 chr5 GO:0007167 Not Cancer Driver No 56 0.269 34 11 0.324 2
FGF21 FGF21 Q9NSA1 Fibroblast growth factor 21 chr19 GO:0007167 Not Cancer Driver No 37 0.177 109 24 0.22 0
FGF23 FGF23 Q9GZV9 Fibroblast growth factor 23 chr12 GO:0007167 Not Cancer Driver No 84 0.335 97 51 0.526 7
FGFR2_ENST00000358487 FGFR2 P21802 Fibroblast growth factor receptor 2 chr10 GO:0007167 Census, Compendium Yes 238 0.29 228 44 0.193 72
FGFR3_ENST00000440486 FGFR3 P22607 Fibroblast growth factor receptor 3 chr4 GO:0007167 Census, Compendium Yes 173 0.215 241 26 0.108 37
FLT1 FLT1 P17948 Vascular endothelial growth factor receptor 1 chr13 GO:0007167 Not Cancer Driver No 299 0.223 103 20 0.194 0
FLT3 FLT3 P36888 Receptor-type tyrosine-protein kinase FLT3 chr13 GO:0007167 Census, Compendium Yes 200 0.201 64 27 0.422 0
FLT4 FLT4 P35916 Vascular endothelial growth factor receptor 3 chr5 GO:0007167 Census, Compendium Yes 253 0.186 259 41 0.158 13
FOXC1_ENST00000645831 FOXC1 Q12948 Forkhead box protein C1 chr6 GO:0007167 Not Cancer Driver No 33 0.06 411 24 0.058 32
FOXC2 FOXC2 Q99958 Forkhead box protein C2 chr16 GO:0007167 Not Cancer Driver No 63 0.126 369 33 0.089 1
FOXH1 FOXH1 O75593 Forkhead box protein H1 chr8 GO:0007167 Not Cancer Driver No 47 0.129 215 25 0.116 0
FRS2 FRS2 Q8WU20 Fibroblast growth factor receptor substrate 2 chr12 GO:0007167 Not Cancer Driver No 69 0.136 415 58 0.14 0
FYN FYN P06241 Tyrosine-protein kinase Fyn chr6 GO:0007167 Not Cancer Driver No 92 0.171 70 13 0.186 0
GAB1_ENST00000262994 GAB1 Q13480 GRB2-associated-binding protein 1 chr4 GO:0007167 Not Cancer Driver No 79 0.114 570 68 0.119 1
GAS6 GAS6 Q14393 Growth arrest-specific protein 6 chr13 GO:0007167 Not Cancer Driver No 82 0.121 42 6 0.143 0
GDF15 GDF15 Q99988 Growth/differentiation factor 15 chr19 GO:0007167 Not Cancer Driver No 39 0.127 143 20 0.14 0
GFRA1 GFRA1 P56159 GDNF family receptor alpha-1 chr10 GO:0007167 Not Cancer Driver No 120 0.258 43 12 0.279 0
GFRA2 GFRA2 O00451 GDNF family receptor alpha-2 chr8 GO:0007167 Not Cancer Driver No 60 0.129 71 25 0.352 0
GFRA3 GFRA3 O60609 GDNF family receptor alpha-3 chr5 GO:0007167 Not Cancer Driver No 50 0.125 40 4 0.1 0
GFRA4 GFRA4 Q9GZZ7 GDNF family receptor alpha-4 chr20 GO:0007167 Not Cancer Driver No 13 0.043 85 4 0.047 0
GFRAL GFRAL Q6UXV0 GDNF family receptor alpha-like chr6 GO:0007167 Not Cancer Driver No 176 0.447 5 2 0.4 0
GH1 GH1 P01241 Somatotropin chr17 GO:0007167 Not Cancer Driver No 54 0.249 24 9 0.375 15
GH2_ENST00000423893 GH2 P01242 Growth hormone variant chr17 GO:0007167 Not Cancer Driver No 55 0.253 12 9 0.75 0
GHR_ENST00000612382 GHR P10912 Growth hormone receptor chr5 GO:0007167 Not Cancer Driver No 173 0.271 229 66 0.288 19
GIGYF1_ENST00000646601 GIGYF1 O75420 GRB10-interacting GYF protein 1 chr7 GO:0007167 Not Cancer Driver No 138 0.133 857 115 0.134 0
GIGYF2_ENST00000409547 GIGYF2 Q6Y7W6 GRB10-interacting GYF protein 2 chr2 GO:0007167 Not Cancer Driver No 176 0.135 1096 158 0.144 6
GIT1_ENST00000225394 GIT1 Q9Y2X7 ARF GTPase-activating protein GIT1 chr17 GO:0007167 Not Cancer Driver No 67 0.088 434 42 0.097 0
GP6_ENST00000417454 GP6 Q9HCN6 Platelet glycoprotein VI chr19 GO:0007167 Not Cancer Driver No 57 0.168 122 21 0.172 2
GRB10_ENST00000401949 GRB10 Q13322 Growth factor receptor-bound protein 10 chr7 GO:0007167 Not Cancer Driver No 94 0.158 220 38 0.173 0
GUCA1B GUCA1B Q9UMX6 Guanylyl cyclase-activating protein 2 chr6 GO:0007167 Not Cancer Driver No 26 0.13 2 0 0.0 1
GUCY2C GUCY2C P25092 Guanylyl cyclase C chr12 GO:0007167 Not Cancer Driver No 209 0.195 51 7 0.137 2
GUCY2D GUCY2D Q02846 Retinal guanylyl cyclase 1 chr17 GO:0007167 Not Cancer Driver No 138 0.125 205 34 0.166 32
GUCY2F GUCY2F P51841 Retinal guanylyl cyclase 2 chrX GO:0007167 Not Cancer Driver No 230 0.208 88 15 0.17 0
HAP1_ENST00000310778 HAP1 P54257 Huntingtin-associated protein 1 chr17 GO:0007167 Not Cancer Driver No 97 0.145 454 60 0.132 0
HESX1 HESX1 Q9UBX0 Homeobox expressed in ES cells 1 chr3 GO:0007167 Not Cancer Driver No 32 0.173 59 9 0.153 6
HGF_ENST00000644543 HGF P14210 Hepatocyte growth factor chr7 GO:0007167 Compendium Yes 233 0.32 43 16 0.372 0
HSPB1 HSPB1 P04792 Heat shock protein beta-1 chr7 GO:0007167 Not Cancer Driver No 10 0.049 118 8 0.068 20
IGF1R IGF1R P08069 Insulin-like growth factor 1 receptor chr15 GO:0007167 Not Cancer Driver No 183 0.134 265 37 0.14 6
IGF1_ENST00000307046 IGF1 P05019 Insulin-like growth factor I chr12 GO:0007167 Not Cancer Driver No 45 0.231 87 23 0.264 0
IGF2R IGF2R P11717 Cation-independent mannose-6-phosphate receptor chr6 GO:0007167 Not Cancer Driver No 318 0.128 255 20 0.078 0
IGF2_ENST00000641326 IGF2 P01344 Insulin-like growth factor II chr11 GO:0007167 Not Cancer Driver No 39 0.217 44 12 0.273 0
IL13RA1 IL13RA1 P78552 Interleukin-13 receptor subunit alpha-1 chrX GO:0007167 Not Cancer Driver No 58 0.136 33 7 0.212 0
IL6ST_ENST00000336909 IL6ST P40189 Interleukin-6 receptor subunit beta chr5 GO:0007167 Census, Compendium Yes 102 0.111 315 40 0.127 2
IQGAP1 IQGAP1 P46940 Ras GTPase-activating-like protein IQGAP1 chr15 GO:0007167 Not Cancer Driver No 183 0.11 351 35 0.1 0
IRS1 IRS1 P35568 Insulin receptor substrate 1 chr2 GO:0007167 Not Cancer Driver No 161 0.13 1072 133 0.124 2
JAK1 JAK1 P23458 Tyrosine-protein kinase JAK1 chr1 GO:0007167 Census, Compendium Yes 147 0.127 120 7 0.058 2
JAK2 JAK2 O60674 Tyrosine-protein kinase JAK2 chr9 GO:0007167 Census, Compendium Yes 136 0.12 59 5 0.085 5
JAK3 JAK3 P52333 Tyrosine-protein kinase JAK3 chr19 GO:0007167 Census, Compendium Yes 167 0.149 63 10 0.159 7
KALRN_ENST00000360013 KALRN O60229 Kalirin chr3 GO:0007167 Not Cancer Driver No 544 0.182 732 128 0.175 0
KDR KDR P35968 Vascular endothelial growth factor receptor 2 chr4 GO:0007167 Census, Compendium Yes 357 0.263 275 55 0.2 2
KIT KIT P10721 Mast/stem cell growth factor receptor Kit chr4 GO:0007167 Census, Compendium Yes 226 0.232 83 33 0.398 21
KL KL Q9UEF7 Klotho chr13 GO:0007167 Not Cancer Driver No 175 0.173 104 5 0.048 1
KLB KLB Q86Z14 Beta-klotho chr4 GO:0007167 Not Cancer Driver No 139 0.133 6 1 0.167 0
LIF LIF P15018 Leukemia inhibitory factor chr22 GO:0007167 Not Cancer Driver No 25 0.124 0 0 0.0 0
LIFR_ENST00000453190 LIFR P42702 Leukemia inhibitory factor receptor chr5 GO:0007167 Census, Compendium Yes 247 0.225 259 56 0.216 1
LOX LOX P28300 Protein-lysine 6-oxidase chr5 GO:0007167 Compendium Yes 44 0.106 172 11 0.064 4
LRP1 LRP1 Q07954 Prolow-density lipoprotein receptor-related protein 1 chr12 GO:0007167 Not Cancer Driver No 664 0.146 317 52 0.164 1
LYN LYN P07948 Tyrosine-protein kinase Lyn chr8 GO:0007167 Census Yes 95 0.186 84 12 0.143 0
MAPK14_ENST00000229794 MAPK14 Q16539 Mitogen-activated protein kinase 14 chr6 GO:0007167 Not Cancer Driver No 39 0.108 25 1 0.04 0
MAPKAPK2 MAPKAPK2 P49137 MAP kinase-activated protein kinase 2 chr1 GO:0007167 Not Cancer Driver No 43 0.107 92 5 0.054 0
MAPKAPK3 MAPKAPK3 Q16644 MAP kinase-activated protein kinase 3 chr3 GO:0007167 Not Cancer Driver No 35 0.092 117 12 0.103 1
MET_ENST00000397752 MET P08581 Hepatocyte growth factor receptor chr7 GO:0007167 Census, Compendium Yes 226 0.163 62 15 0.242 19
MMP2 MMP2 P08253 72 kDa type IV collagenase chr16 GO:0007167 Not Cancer Driver No 123 0.186 29 6 0.207 2
MMP9 MMP9 P14780 Matrix metalloproteinase-9 chr20 GO:0007167 Not Cancer Driver No 129 0.182 124 26 0.21 0
MSX1 MSX1 P28360 Homeobox protein MSX-1 chr4 GO:0007167 Not Cancer Driver No 39 0.129 197 16 0.081 7
MSX2 MSX2 P35548 Homeobox protein MSX-2 chr5 GO:0007167 Not Cancer Driver No 27 0.101 168 14 0.083 4
MUC20 MUC20 Q8N307 Mucin-20 chr3 GO:0007167 Not Cancer Driver No 107 0.151 680 100 0.147 0
MUSK MUSK O15146 Muscle, skeletal receptor tyrosine-protein kinase chr9 GO:0007167 Not Cancer Driver No 188 0.216 35 7 0.2 7
MYO1C MYO1C O00159 Unconventional myosin-Ic chr17 GO:0007167 Not Cancer Driver No 110 0.103 66 11 0.167 0
MYO1E MYO1E Q12965 Unconventional myosin-Ie chr15 GO:0007167 Not Cancer Driver No 137 0.124 229 14 0.061 1
MYOC MYOC Q99972 Myocilin chr1 GO:0007167 Not Cancer Driver No 92 0.183 196 43 0.219 58
NCK1_ENST00000288986 NCK1 P16333 Cytoplasmic protein NCK1 chr3 GO:0007167 Not Cancer Driver No 48 0.127 111 17 0.153 0
NCK2_ENST00000393349 NCK2 O43639 Cytoplasmic protein NCK2 chr2 GO:0007167 Not Cancer Driver No 89 0.234 88 19 0.216 0
NDN NDN Q99608 Necdin chr15 GO:0007167 Not Cancer Driver No 123 0.383 117 42 0.359 0
NFATC4_ENST00000250373 NFATC4 Q14934 Nuclear factor of activated T-cells, cytoplasmic 4 chr14 GO:0007167 Not Cancer Driver No 155 0.172 685 120 0.175 0
NGEF NGEF Q8N5V2 Ephexin-1 chr2 GO:0007167 Not Cancer Driver No 125 0.176 296 34 0.115 0
NODAL NODAL Q96S42 Nodal homolog chr10 GO:0007167 Not Cancer Driver No 40 0.115 34 8 0.235 4
NOG NOG Q13253 Noggin chr17 GO:0007167 Not Cancer Driver No 22 0.095 86 9 0.105 20
NPPA NPPA P01160 Natriuretic peptides A chr1 GO:0007167 Not Cancer Driver No 32 0.212 71 14 0.197 1
NPPB NPPB P16860 Natriuretic peptides B chr1 GO:0007167 Not Cancer Driver No 31 0.231 104 28 0.269 0
NPPC NPPC P23582 C-type natriuretic peptide chr2 GO:0007167 Not Cancer Driver No 10 0.079 82 6 0.073 0
NPR1 NPR1 P16066 Atrial natriuretic peptide receptor 1 chr1 GO:0007167 Not Cancer Driver No 141 0.133 78 16 0.205 0
NPR2 NPR2 P20594 Atrial natriuretic peptide receptor 2 chr9 GO:0007167 Not Cancer Driver No 144 0.138 89 18 0.202 20
NR4A3_ENST00000395097 NR4A3 Q92570 Nuclear receptor subfamily 4 group A member 3 chr9 GO:0007167 Census Yes 83 0.133 298 37 0.124 0
NRG1_ENST00000405005 NRG1 Q02297 Pro-neuregulin-1, membrane-bound isoform chr8 GO:0007167 Census, Compendium Yes 159 0.248 528 132 0.25 0
NRP1 NRP1 O14786 Neuropilin-1 chr10 GO:0007167 Compendium Yes 146 0.158 211 31 0.147 0
NRP2 NRP2 O60462 Neuropilin-2 chr2 GO:0007167 Not Cancer Driver No 161 0.173 207 45 0.217 0
NTRK1 NTRK1 P04629 High affinity nerve growth factor receptor chr1 GO:0007167 Census, Compendium Yes 168 0.211 57 8 0.14 25
NTRK2_ENST00000323115 NTRK2 Q16620 BDNF/NT-3 growth factors receptor chr9 GO:0007167 Not Cancer Driver No 155 0.189 117 18 0.154 1
NTRK3_ENST00000629765 NTRK3 Q16288 NT-3 growth factor receptor chr15 GO:0007167 Census, Compendium Yes 249 0.297 57 21 0.368 0
NUS1 NUS1 Q96E22 Dehydrodolichyl diphosphate synthase complex subunit NUS1 chr6 GO:0007167 Not Cancer Driver No 21 0.072 13 0 0.0 1
OSMR OSMR Q99650 Oncostatin-M-specific receptor subunit beta chr5 GO:0007167 Not Cancer Driver No 167 0.171 145 22 0.152 5
OTOL1 OTOL1 A6NHN0 Otolin-1 chr3 GO:0007167 Not Cancer Driver No 121 0.254 321 70 0.218 0
PAK1_ENST00000356341 PAK1 Q13153 Serine/threonine-protein kinase PAK 1 chr11 GO:0007167 Not Cancer Driver No 57 0.105 299 30 0.1 2
PAK2 PAK2 Q13177 Serine/threonine-protein kinase PAK 2 chr3 GO:0007167 Compendium Yes 89 0.17 242 49 0.202 0
PAK3_ENST00000262836 PAK3 O75914 Serine/threonine-protein kinase PAK 3 chrX GO:0007167 Not Cancer Driver No 127 0.227 286 64 0.224 2
PDCD6 PDCD6 O75340 Programmed cell death protein 6 chr5 GO:0007167 Not Cancer Driver No 21 0.11 24 1 0.042 0
PDGFA PDGFA P04085 Platelet-derived growth factor subunit A chr7 GO:0007167 Not Cancer Driver No 31 0.147 75 10 0.133 0
PDGFB PDGFB P01127 Platelet-derived growth factor subunit B chr22 GO:0007167 Census Yes 37 0.154 99 22 0.222 2
PDGFC PDGFC Q9NRA1 Platelet-derived growth factor C chr4 GO:0007167 Not Cancer Driver No 86 0.249 53 12 0.226 0
PDGFD PDGFD Q9GZP0 Platelet-derived growth factor D chr11 GO:0007167 Not Cancer Driver No 85 0.23 37 13 0.351 0
PDGFRA PDGFRA P16234 Platelet-derived growth factor receptor alpha chr4 GO:0007167 Census, Compendium Yes 290 0.266 173 45 0.26 2
PDGFRB PDGFRB P09619 Platelet-derived growth factor receptor beta chr5 GO:0007167 Census, Compendium Yes 164 0.148 231 44 0.19 7
PDGFRL PDGFRL Q15198 Platelet-derived growth factor receptor-like protein chr8 GO:0007167 Not Cancer Driver No 46 0.123 67 12 0.179 1
PDZD3_ENST00000531114 PDZD3 Q86UT5 Na(+)/H(+) exchange regulatory cofactor NHE-RF4 chr11 GO:0007167 Not Cancer Driver No 58 0.102 199 19 0.095 0
PGF_ENST00000405431 PGF P49763 Placenta growth factor chr14 GO:0007167 Not Cancer Driver No 30 0.136 72 10 0.139 0
PIK3C2A PIK3C2A O00443 Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha chr11 GO:0007167 Not Cancer Driver No 187 0.111 350 43 0.123 0
PIK3CA PIK3CA P42336 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform chr3 GO:0007167 Census, Compendium Yes 1669 1.563 38 11 0.289 30
PIK3CD PIK3CD O00329 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform chr1 GO:0007167 Not Cancer Driver No 140 0.134 60 13 0.217 1
PIK3R1 PIK3R1 P27986 Phosphatidylinositol 3-kinase regulatory subunit alpha chr5 GO:0007167 Census, Compendium Yes 154 0.213 268 61 0.228 2
PLAT PLAT P00750 Tissue-type plasminogen activator chr8 GO:0007167 Not Cancer Driver No 89 0.158 15 2 0.133 0
PLCB1 PLCB1 Q9NQ66 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 chr20 GO:0007167 Not Cancer Driver No 313 0.257 481 104 0.216 0
PLEKHA1 PLEKHA1 Q9HB21 Pleckstrin homology domain-containing family A member 1 chr10 GO:0007167 Not Cancer Driver No 61 0.151 191 32 0.168 0
PRKD1_ENST00000616995 PRKD1 Q15139 Serine/threonine-protein kinase D1 chr14 GO:0007167 Census Yes 201 0.22 189 33 0.175 2
PRKD2_ENST00000291281 PRKD2 Q9BZL6 Serine/threonine-protein kinase D2 chr19 GO:0007167 Compendium Yes 118 0.134 246 34 0.138 0
PRLR PRLR P16471 Prolactin receptor chr5 GO:0007167 Not Cancer Driver No 154 0.248 282 70 0.248 2
PTK2B_ENST00000346049 PTK2B Q14289 Protein-tyrosine kinase 2-beta chr8 GO:0007167 Not Cancer Driver No 161 0.16 261 37 0.142 0
PTK2_ENST00000522684 PTK2 Q05397 Focal adhesion kinase 1 chr8 GO:0007167 Not Cancer Driver No 134 0.127 425 55 0.129 0
PTK6 PTK6 Q13882 Protein-tyrosine kinase 6 chr20 GO:0007167 Census Yes 42 0.093 12 0 0.0 0
PTN PTN P21246 Pleiotrophin chr7 GO:0007167 Not Cancer Driver No 43 0.256 51 11 0.216 0
PTPN1 PTPN1 P18031 Tyrosine-protein phosphatase non-receptor type 1 chr20 GO:0007167 Not Cancer Driver No 49 0.113 140 25 0.179 0
PTPN11_ENST00000351677 PTPN11 Q06124 Tyrosine-protein phosphatase non-receptor type 11 chr12 GO:0007167 Census, Compendium Yes 129 0.218 260 38 0.146 60
PTPRD PTPRD P23468 Receptor-type tyrosine-protein phosphatase delta chr9 GO:0007167 Census, Compendium Yes 577 0.302 747 219 0.293 0
PTPRF PTPRF P10586 Receptor-type tyrosine-protein phosphatase F chr1 GO:0007167 Not Cancer Driver No 268 0.141 696 96 0.138 0
PTPRJ PTPRJ Q12913 Receptor-type tyrosine-protein phosphatase eta chr11 GO:0007167 Not Cancer Driver No 184 0.138 401 61 0.152 0
PTPRR PTPRR Q15256 Receptor-type tyrosine-protein phosphatase R chr12 GO:0007167 Not Cancer Driver No 172 0.262 73 28 0.384 0
PTPRU PTPRU Q92729 Receptor-type tyrosine-protein phosphatase U chr1 GO:0007167 Not Cancer Driver No 248 0.172 325 64 0.197 0
PXN_ENST00000228307 PXN P49023 Paxillin chr12 GO:0007167 Not Cancer Driver No 62 0.105 341 24 0.07 0
RAC1_ENST00000348035 RAC1 P63000 Ras-related C3 botulinum toxin substrate 1 chr7 GO:0007167 Census, Compendium Yes 66 0.344 2 1 0.5 6
RAF1 RAF1 P04049 RAF proto-oncogene serine/threonine-protein kinase chr3 GO:0007167 Census, Compendium Yes 89 0.137 169 38 0.225 22
RAPGEF2 RAPGEF2 Q9Y4G8 Rap guanine nucleotide exchange factor 2 chr4 GO:0007167 Not Cancer Driver No 216 0.144 803 116 0.144 0
RASA1 RASA1 P20936 Ras GTPase-activating protein 1 chr5 GO:0007167 Compendium Yes 154 0.147 181 25 0.138 3
RASSF2 RASSF2 P50749 Ras association domain-containing protein 2 chr20 GO:0007167 Not Cancer Driver No 90 0.276 126 44 0.349 0
RET RET P07949 Proto-oncogene tyrosine-protein kinase receptor Ret chr10 GO:0007167 Census, Compendium Yes 208 0.187 105 12 0.114 139
RGS14 RGS14 O43566 Regulator of G-protein signaling 14 chr5 GO:0007167 Not Cancer Driver No 57 0.101 309 37 0.12 0
SGPL1 SGPL1 O95470 Sphingosine-1-phosphate lyase 1 chr10 GO:0007167 Not Cancer Driver No 68 0.12 19 3 0.158 2
SIPA1L1 SIPA1L1 O43166 Signal-induced proliferation-associated 1-like protein 1 chr14 GO:0007167 Not Cancer Driver No 321 0.178 1175 226 0.192 0
SIRT2 SIRT2 Q8IXJ6 NAD-dependent protein deacetylase sirtuin-2 chr19 GO:0007167 Not Cancer Driver No 56 0.144 85 17 0.2 0
SMAD2_ENST00000402690 SMAD2 Q15796 Mothers against decapentaplegic homolog 2 chr18 GO:0007167 Census, Compendium Yes 79 0.169 137 12 0.088 0
SMAD3 SMAD3 P84022 Mothers against decapentaplegic homolog 3 chr15 GO:0007167 Census, Compendium Yes 97 0.228 111 19 0.171 5
SMPD3 SMPD3 Q9NY59 Sphingomyelin phosphodiesterase 3 chr16 GO:0007167 Not Cancer Driver No 92 0.14 224 29 0.129 0
SOCS2_ENST00000536696 SOCS2 O14508 Suppressor of cytokine signaling 2 chr12 GO:0007167 Not Cancer Driver No 32 0.162 61 2 0.033 0
SORT1 SORT1 Q99523 Sortilin chr1 GO:0007167 Not Cancer Driver No 69 0.083 110 2 0.018 0
SOS1_ENST00000402219 SOS1 Q07889 Son of sevenless homolog 1 chr2 GO:0007167 Compendium Yes 197 0.148 458 62 0.135 38
SRC_ENST00000358208 SRC P12931 Proto-oncogene tyrosine-protein kinase Src chr20 GO:0007167 Census Yes 53 0.099 130 11 0.085 1
SS18 SS18 Q15532 Protein SSXT chr18 GO:0007167 Census Yes 52 0.124 416 52 0.125 0
STAT3 STAT3 P40763 Signal transducer and activator of transcription 3 chr17 GO:0007167 Census, Compendium Yes 110 0.143 152 15 0.099 19
STAT5A_ENST00000590949 STAT5A P42229 Signal transducer and activator of transcription 5A chr17 GO:0007167 Not Cancer Driver No 89 0.112 125 14 0.112 0
STAT5B STAT5B P51692 Signal transducer and activator of transcription 5B chr17 GO:0007167 Census, Compendium Yes 93 0.118 144 19 0.132 5
STAT6_ENST00000543873 STAT6 P42226 Signal transducer and activator of transcription 6 chr12 GO:0007167 Census, Compendium Yes 106 0.125 325 44 0.135 0
STMN1_ENST00000357865 STMN1 P16949 Stathmin chr1 GO:0007167 Not Cancer Driver No 15 0.101 149 15 0.101 0
STUB1 STUB1 Q9UNE7 E3 ubiquitin-protein ligase CHIP chr16 GO:0007167 Not Cancer Driver No 35 0.116 112 14 0.125 12
SULF1_ENST00000458141 SULF1 Q8IWU6 Extracellular sulfatase Sulf-1 chr8 GO:0007167 Not Cancer Driver No 246 0.282 269 71 0.264 0
SULF2_ENST00000484875 SULF2 Q8IWU5 Extracellular sulfatase Sulf-2 chr20 GO:0007167 Not Cancer Driver No 145 0.167 142 18 0.127 0
SVEP1 SVEP1 Q4LDE5 Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 chr9 GO:0007167 Not Cancer Driver No 626 0.175 229 33 0.144 0
SYK_ENST00000375746 SYK P43405 Tyrosine-protein kinase SYK chr9 GO:0007167 Census Yes 96 0.151 131 27 0.206 5
TDGF1 TDGF1 P13385 Teratocarcinoma-derived growth factor 1 chr3 GO:0007167 Not Cancer Driver No 39 0.207 25 2 0.08 0
TEK TEK Q02763 Angiopoietin-1 receptor chr9 GO:0007167 Not Cancer Driver No 219 0.195 126 22 0.175 10
TGFB1 TGFB1 P01137 Transforming growth factor beta-1 proprotein chr19 GO:0007167 Not Cancer Driver No 41 0.105 41 4 0.098 10
TGIF2_ENST00000611732 TGIF2 Q9GZN2 Homeobox protein TGIF2 chr20 GO:0007167 Not Cancer Driver No 37 0.156 171 23 0.135 0
TIAM1 TIAM1 Q13009 Rho guanine nucleotide exchange factor TIAM1 chr21 GO:0007167 Not Cancer Driver No 370 0.233 810 194 0.24 0
TIPARP TIPARP Q7Z3E1 Protein mono-ADP-ribosyltransferase TIPARP chr3 GO:0007167 Not Cancer Driver No 65 0.099 200 20 0.1 0
TRIO TRIO O75962 Triple functional domain protein chr5 GO:0007167 Not Cancer Driver No 400 0.129 1052 118 0.112 10
TSC2 TSC2 P49815 Tuberin chr16 GO:0007167 Census, Compendium Yes 192 0.106 563 50 0.089 53
TXNIP TXNIP Q9H3M7 Thioredoxin-interacting protein chr1 GO:0007167 Not Cancer Driver No 61 0.156 77 14 0.182 0
TYK2 TYK2 P29597 Non-receptor tyrosine-protein kinase TYK2 chr19 GO:0007167 Not Cancer Driver No 148 0.125 213 29 0.136 0
UBASH3B UBASH3B Q8TF42 Ubiquitin-associated and SH3 domain-containing protein B chr11 GO:0007167 Not Cancer Driver No 86 0.133 73 6 0.082 0
VAV1 VAV1 P15498 Proto-oncogene vav chr19 GO:0007167 Census, Compendium Yes 165 0.195 113 19 0.168 0
VAV2 VAV2 P52735 Guanine nucleotide exchange factor VAV2 chr9 GO:0007167 Not Cancer Driver No 127 0.145 135 17 0.126 0
VEGFA_ENST00000523873 VEGFA P15692 Vascular endothelial growth factor A chr6 GO:0007167 Not Cancer Driver No 27 0.116 41 7 0.171 0
VEGFB VEGFB P49765 Vascular endothelial growth factor B chr11 GO:0007167 Not Cancer Driver No 25 0.121 125 22 0.176 0
VEGFC VEGFC P49767 Vascular endothelial growth factor C chr4 GO:0007167 Not Cancer Driver No 128 0.305 37 12 0.324 0
VEGFD VEGFD O43915 Vascular endothelial growth factor D chrX GO:0007167 Not Cancer Driver No 59 0.167 33 6 0.182 0
YES1_ENST00000314574 YES1 P07947 Tyrosine-protein kinase Yes chr18 GO:0007167 Not Cancer Driver No 65 0.12 62 10 0.161 0
ZFAND5 ZFAND5 O76080 AN1-type zinc finger protein 5 chr9 GO:0007167 Not Cancer Driver No 31 0.146 162 19 0.117 0
ZFYVE27_ENST00000393677 ZFYVE27 Q5T4F4 Protrudin chr10 GO:0007167 Not Cancer Driver No 45 0.109 140 22 0.157 1