Total number of protein in "GO:0000724" GO term: 91
| Identifier | UniProt Gene | UniProt Accession | UniProt Name | Chromosome | GO term | Database | Cancer Driver | Number of missense mutations | Missense mutation per residues | Number of disordered residues | Number of mutations in disordered regions | Disordered missense mutations per residues | Number of OMIM mutation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AP5S1_ENST00000246041 | AP5S1 | Q9NUS5 | AP-5 complex subunit sigma-1 | chr20 | GO:0000724 | Not Cancer Driver | No | 27 | 0.135 | 57 | 7 | 0.123 | 0 |
| AP5Z1 | AP5Z1 | O43299 | AP-5 complex subunit zeta-1 | chr7 | GO:0000724 | Not Cancer Driver | No | 98 | 0.121 | 94 | 11 | 0.117 | 0 |
| ATM_ENST00000452508 | ATM | Q13315 | Serine-protein kinase ATM | chr11 | GO:0000724 | Census, Compendium | Yes | 469 | 0.153 | 225 | 39 | 0.173 | 41 |
| AUNIP_ENST00000374298 | AUNIP | Q9H7T9 | Aurora kinase A and ninein-interacting protein | chr1 | GO:0000724 | Not Cancer Driver | No | 23 | 0.064 | 341 | 21 | 0.062 | 0 |
| BLM | BLM | P54132 | Bloom syndrome protein | chr15 | GO:0000724 | Census | Yes | 153 | 0.108 | 667 | 70 | 0.105 | 8 |
| BRCA1_ENST00000357654 | BRCA1 | P38398 | Breast cancer type 1 susceptibility protein | chr17 | GO:0000724 | Census, Compendium | Yes | 224 | 0.12 | 1458 | 174 | 0.119 | 35 |
| BRCA2_ENST00000544455 | BRCA2 | P51587 | Breast cancer type 2 susceptibility protein | chr13 | GO:0000724 | Census, Compendium | Yes | 457 | 0.134 | 1542 | 225 | 0.146 | 46 |
| CCDC155 | KASH5 | Q8N6L0 | Protein KASH5 | chr19 | GO:0000724 | Not Cancer Driver | No | 88 | 0.157 | 401 | 70 | 0.175 | 0 |
| ERCC4 | ERCC4 | Q92889 | DNA repair endonuclease XPF | chr16 | GO:0000724 | Census | Yes | 120 | 0.131 | 225 | 27 | 0.12 | 15 |
| ERCC5 | ERCC5 | P28715 | DNA excision repair protein ERCC-5 | chr13 | GO:0000724 | Census | Yes | 175 | 0.148 | 816 | 121 | 0.148 | 6 |
| EXD2 | EXD2 | Q9NVH0 | Exonuclease 3'-5' domain-containing protein 2 | chr14 | GO:0000724 | Not Cancer Driver | No | 58 | 0.093 | 176 | 15 | 0.085 | 0 |
| FAN1 | FAN1 | Q9Y2M0 | Fanconi-associated nuclease 1 | chr15 | GO:0000724 | Not Cancer Driver | No | 124 | 0.122 | 212 | 27 | 0.127 | 4 |
| FANCB | FANCB | Q8NB91 | Fanconi anemia group B protein | chrX | GO:0000724 | Not Cancer Driver | No | 109 | 0.127 | 24 | 5 | 0.208 | 0 |
| FANCM | FANCM | Q8IYD8 | Fanconi anemia group M protein | chr14 | GO:0000724 | Not Cancer Driver | No | 268 | 0.131 | 898 | 128 | 0.143 | 0 |
| FBH1_ENST00000362091 | FBH1 | Q8NFZ0 | F-box DNA helicase 1 | chr10 | GO:0000724 | Not Cancer Driver | No | 139 | 0.133 | 192 | 32 | 0.167 | 0 |
| FEN1 | FEN1 | P39748 | Flap endonuclease 1 | chr11 | GO:0000724 | Census | Yes | 35 | 0.092 | 111 | 11 | 0.099 | 0 |
| GEN1_ENST00000381254 | GEN1 | Q17RS7 | Flap endonuclease GEN homolog 1 | chr2 | GO:0000724 | Not Cancer Driver | No | 109 | 0.12 | 339 | 52 | 0.153 | 0 |
| H2AFX | H2AX | P16104 | Histone H2AX | chr11 | GO:0000724 | Not Cancer Driver | No | 20 | 0.14 | 68 | 10 | 0.147 | 0 |
| HELQ | HELQ | Q8TDG4 | Helicase POLQ-like | chr4 | GO:0000724 | Not Cancer Driver | No | 134 | 0.122 | 273 | 19 | 0.07 | 0 |
| HUS1 | HUS1 | O60921 | Checkpoint protein HUS1 | chr7 | GO:0000724 | Not Cancer Driver | No | 25 | 0.089 | 17 | 2 | 0.118 | 0 |
| HUS1B | HUS1B | Q8NHY5 | Checkpoint protein HUS1B | chr6 | GO:0000724 | Not Cancer Driver | No | 50 | 0.18 | 10 | 1 | 0.1 | 0 |
| INIP | INIP | Q9NRY2 | SOSS complex subunit C | chr9 | GO:0000724 | Not Cancer Driver | No | 25 | 0.24 | 79 | 16 | 0.203 | 0 |
| INO80_ENST00000401393 | INO80 | Q9ULG1 | Chromatin-remodeling ATPase INO80 | chr15 | GO:0000724 | Compendium | Yes | 173 | 0.111 | 682 | 76 | 0.111 | 0 |
| INTS3_ENST00000435409 | INTS3 | Q68E01 | Integrator complex subunit 3 | chr1 | GO:0000724 | Not Cancer Driver | No | 125 | 0.12 | 213 | 25 | 0.117 | 0 |
| KDM4D_ENST00000610872 | KDM4D | Q6B0I6 | Lysine-specific demethylase 4D | chr11 | GO:0000724 | Not Cancer Driver | No | 78 | 0.149 | 215 | 33 | 0.153 | 0 |
| LIG3 | LIG3 | P49916 | DNA ligase 3 | chr17 | GO:0000724 | Not Cancer Driver | No | 125 | 0.124 | 280 | 36 | 0.129 | 0 |
| MCM8_ENST00000378896 | MCM8 | Q9UJA3 | DNA helicase MCM8 | chr20 | GO:0000724 | Not Cancer Driver | No | 94 | 0.112 | 188 | 19 | 0.101 | 1 |
| MCM9_ENST00000619706 | MCM9 | Q9NXL9 | DNA helicase MCM9 | chr6 | GO:0000724 | Not Cancer Driver | No | 56 | 0.049 | 523 | 13 | 0.025 | 0 |
| MEIOB_ENST00000397344 | MEIOB | Q8N635 | Meiosis-specific with OB domain-containing protein | chr16 | GO:0000724 | Not Cancer Driver | No | 37 | 0.084 | 21 | 2 | 0.095 | 1 |
| MMS22L | MMS22L | Q6ZRQ5 | Protein MMS22-like | chr6 | GO:0000724 | Not Cancer Driver | No | 162 | 0.13 | 13 | 2 | 0.154 | 0 |
| MORF4L1 | MORF4L1 | Q9UBU8 | Mortality factor 4-like protein 1 | chr15 | GO:0000724 | Not Cancer Driver | No | 43 | 0.119 | 163 | 17 | 0.104 | 0 |
| MRE11 | MRE11 | P49959 | Double-strand break repair protein MRE11 | chr11 | GO:0000724 | Not Cancer Driver | No | 84 | 0.119 | 292 | 35 | 0.12 | 1 |
| NABP1 | NABP1 | Q96AH0 | SOSS complex subunit B2 | chr2 | GO:0000724 | Not Cancer Driver | No | 25 | 0.123 | 102 | 11 | 0.108 | 0 |
| NABP2_ENST00000341463 | NABP2 | Q9BQ15 | SOSS complex subunit B1 | chr12 | GO:0000724 | Not Cancer Driver | No | 25 | 0.118 | 125 | 17 | 0.136 | 0 |
| NBN | NBN | O60934 | Nibrin | chr8 | GO:0000724 | Census | Yes | 90 | 0.119 | 417 | 54 | 0.129 | 1 |
| NIPBL | NIPBL | Q6KC79 | Nipped-B-like protein | chr5 | GO:0000724 | Compendium | Yes | 353 | 0.126 | 1528 | 184 | 0.12 | 37 |
| NSMCE1 | NSMCE1 | Q8WV22 | Non-structural maintenance of chromosomes element 1 homolog | chr16 | GO:0000724 | Not Cancer Driver | No | 40 | 0.15 | 31 | 8 | 0.258 | 0 |
| NSMCE2_ENST00000522563 | NSMCE2 | Q96MF7 | E3 SUMO-protein ligase NSE2 | chr8 | GO:0000724 | Not Cancer Driver | No | 30 | 0.121 | 119 | 12 | 0.101 | 0 |
| NUCKS1 | NUCKS1 | Q9H1E3 | Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 | chr1 | GO:0000724 | Not Cancer Driver | No | 30 | 0.123 | 243 | 30 | 0.123 | 0 |
| PALB2 | PALB2 | Q86YC2 | Partner and localizer of BRCA2 | chr16 | GO:0000724 | Census | Yes | 124 | 0.105 | 769 | 77 | 0.1 | 1 |
| POLL_ENST00000370169 | POLL | Q9UGP5 | DNA polymerase lambda | chr10 | GO:0000724 | Not Cancer Driver | No | 69 | 0.12 | 215 | 16 | 0.074 | 0 |
| POLN_ENST00000382865 | POLN | Q7Z5Q5 | DNA polymerase nu | chr4 | GO:0000724 | Not Cancer Driver | No | 115 | 0.128 | 247 | 28 | 0.113 | 0 |
| PPP4C_ENST00000561610 | PPP4C | P60510 | Serine/threonine-protein phosphatase 4 catalytic subunit | chr16 | GO:0000724 | Not Cancer Driver | No | 41 | 0.134 | 0 | 0 | 0.0 | 0 |
| PSMD14 | PSMD14 | O00487 | 26S proteasome non-ATPase regulatory subunit 14 | chr2 | GO:0000724 | Not Cancer Driver | No | 23 | 0.074 | 67 | 6 | 0.09 | 0 |
| RAD21 | RAD21 | O60216 | Double-strand-break repair protein rad21 homolog | chr8 | GO:0000724 | Census, Compendium | Yes | 115 | 0.182 | 421 | 74 | 0.176 | 3 |
| RAD21L1 | RAD21L1 | Q9H4I0 | Double-strand-break repair protein rad21-like protein 1 | chr20 | GO:0000724 | Not Cancer Driver | No | 37 | 0.067 | 186 | 5 | 0.027 | 0 |
| RAD51AP1 | RAD51AP1 | Q96B01 | RAD51-associated protein 1 | chr12 | GO:0000724 | Not Cancer Driver | No | 46 | 0.131 | 335 | 43 | 0.128 | 0 |
| RAD51AP2 | RAD51AP2 | Q09MP3 | RAD51-associated protein 2 | chr2 | GO:0000724 | Not Cancer Driver | No | 202 | 0.174 | 371 | 66 | 0.178 | 0 |
| RAD51B_ENST00000487270 | RAD51B | O15315 | DNA repair protein RAD51 homolog 2 | chr14 | GO:0000724 | Census | Yes | 45 | 0.117 | 13 | 0 | 0.0 | 0 |
| RAD51C | RAD51C | O43502 | DNA repair protein RAD51 homolog 3 | chr17 | GO:0000724 | Not Cancer Driver | No | 47 | 0.125 | 18 | 2 | 0.111 | 6 |
| RAD51D_ENST00000394589 | RAD51D | O75771 | DNA repair protein RAD51 homolog 4 | chr17 | GO:0000724 | Not Cancer Driver | No | 34 | 0.104 | 49 | 10 | 0.204 | 0 |
| RAD51_ENST00000267868 | RAD51 | Q06609 | DNA repair protein RAD51 homolog 1 | chr15 | GO:0000724 | Not Cancer Driver | No | 42 | 0.124 | 47 | 5 | 0.106 | 3 |
| RAD52 | RAD52 | P43351 | DNA repair protein RAD52 homolog | chr12 | GO:0000724 | Not Cancer Driver | No | 41 | 0.098 | 251 | 30 | 0.12 | 0 |
| RAD54B | RAD54B | Q9Y620 | DNA repair and recombination protein RAD54B | chr8 | GO:0000724 | Not Cancer Driver | No | 112 | 0.123 | 120 | 16 | 0.133 | 0 |
| RAD54L_ENST00000442598 | RAD54L | Q92698 | DNA repair and recombination protein RAD54-like | chr1 | GO:0000724 | Not Cancer Driver | No | 79 | 0.106 | 124 | 13 | 0.105 | 0 |
| RBBP8_ENST00000327155 | RBBP8 | Q99708 | DNA endonuclease RBBP8 | chr18 | GO:0000724 | Not Cancer Driver | No | 99 | 0.11 | 750 | 76 | 0.101 | 1 |
| REC8_ENST00000611366 | REC8 | O95072 | Meiotic recombination protein REC8 homolog | chr14 | GO:0000724 | Not Cancer Driver | No | 60 | 0.11 | 244 | 26 | 0.107 | 0 |
| RECQL4 | RECQL4 | O94761 | ATP-dependent DNA helicase Q4 | chr8 | GO:0000724 | Census, Compendium | Yes | 138 | 0.114 | 608 | 71 | 0.117 | 1 |
| RECQL5 | RECQL5 | O94762 | ATP-dependent DNA helicase Q5 | chr17 | GO:0000724 | Not Cancer Driver | No | 132 | 0.133 | 495 | 71 | 0.143 | 0 |
| RECQL_ENST00000421138 | RECQL | P46063 | ATP-dependent DNA helicase Q1 | chr12 | GO:0000724 | Not Cancer Driver | No | 67 | 0.103 | 91 | 5 | 0.055 | 0 |
| REV3L_ENST00000368802 | REV3L | O60673 | DNA polymerase zeta catalytic subunit | chr6 | GO:0000724 | Not Cancer Driver | No | 379 | 0.121 | 1665 | 211 | 0.127 | 0 |
| RFWD3 | RFWD3 | Q6PCD5 | E3 ubiquitin-protein ligase RFWD3 | chr16 | GO:0000724 | Census | Yes | 68 | 0.088 | 318 | 30 | 0.094 | 1 |
| RMI1 | RMI1 | Q9H9A7 | RecQ-mediated genome instability protein 1 | chr9 | GO:0000724 | Not Cancer Driver | No | 67 | 0.107 | 243 | 26 | 0.107 | 0 |
| RMI2 | RMI2 | Q96E14 | RecQ-mediated genome instability protein 2 | chr16 | GO:0000724 | Census | Yes | 12 | 0.082 | 86 | 5 | 0.058 | 0 |
| RNF138 | RNF138 | Q8WVD3 | E3 ubiquitin-protein ligase RNF138 | chr18 | GO:0000724 | Not Cancer Driver | No | 44 | 0.18 | 34 | 6 | 0.176 | 0 |
| RPA1 | RPA1 | P27694 | Replication protein A 70 kDa DNA-binding subunit | chr17 | GO:0000724 | Not Cancer Driver | No | 51 | 0.083 | 98 | 6 | 0.061 | 0 |
| RPA2_ENST00000373912 | RPA2 | P15927 | Replication protein A 32 kDa subunit | chr1 | GO:0000724 | Not Cancer Driver | No | 28 | 0.104 | 114 | 16 | 0.14 | 0 |
| RPA3 | RPA3 | P35244 | Replication protein A 14 kDa subunit | chr7 | GO:0000724 | Not Cancer Driver | No | 13 | 0.107 | 4 | 1 | 0.25 | 0 |
| RPA4 | RPA4 | Q13156 | Replication protein A 30 kDa subunit | chrX | GO:0000724 | Not Cancer Driver | No | 66 | 0.253 | 58 | 15 | 0.259 | 0 |
| SAMHD1 | SAMHD1 | Q9Y3Z3 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | chr20 | GO:0000724 | Not Cancer Driver | No | 104 | 0.166 | 91 | 14 | 0.154 | 13 |
| SEM1_ENST00000356686 | SEM1 | Q6ZVN7 | Putative protein SEM1, isoform 2 | chr7 | GO:0000724 | Not Cancer Driver | No | 2 | 0.016 | 52 | 1 | 0.019 | 0 |
| SFPQ | SFPQ | P23246 | Splicing factor, proline- and glutamine-rich | chr1 | GO:0000724 | Census | Yes | 59 | 0.083 | 595 | 48 | 0.081 | 0 |
| SFR1 | SFR1 | Q86XK3 | Swi5-dependent recombination DNA repair protein 1 homolog | chr10 | GO:0000724 | Not Cancer Driver | No | 21 | 0.086 | 109 | 12 | 0.11 | 0 |
| SLX1B | SLX1B | Q9BQ83 | Structure-specific endonuclease subunit SLX1 | chr16 | GO:0000724 | Not Cancer Driver | No | 3 | 0.011 | 80 | 1 | 0.013 | 0 |
| SLX4 | SLX4 | Q8IY92 | Structure-specific endonuclease subunit SLX4 | chr16 | GO:0000724 | Not Cancer Driver | No | 271 | 0.148 | 1573 | 232 | 0.147 | 0 |
| SMC5 | SMC5 | Q8IY18 | Structural maintenance of chromosomes protein 5 | chr9 | GO:0000724 | Not Cancer Driver | No | 126 | 0.114 | 378 | 43 | 0.114 | 0 |
| SMC6_ENST00000351948 | SMC6 | Q96SB8 | Structural maintenance of chromosomes protein 6 | chr2 | GO:0000724 | Not Cancer Driver | No | 128 | 0.117 | 458 | 57 | 0.124 | 0 |
| SPIDR | SPIDR | Q14159 | DNA repair-scaffolding protein | chr8 | GO:0000724 | Not Cancer Driver | No | 101 | 0.11 | 329 | 20 | 0.061 | 0 |
| SWI5 | SWI5 | Q1ZZU3 | DNA repair protein SWI5 homolog | chr9 | GO:0000724 | Not Cancer Driver | No | 45 | 0.191 | 128 | 35 | 0.273 | 0 |
| SWSAP1 | SWSAP1 | Q6NVH7 | ATPase SWSAP1 | chr19 | GO:0000724 | Not Cancer Driver | No | 26 | 0.114 | 104 | 14 | 0.135 | 0 |
| TONSL | TONSL | Q96HA7 | Tonsoku-like protein | chr8 | GO:0000724 | Not Cancer Driver | No | 156 | 0.113 | 545 | 60 | 0.11 | 8 |
| TOP3A | TOP3A | Q13472 | DNA topoisomerase 3-alpha | chr17 | GO:0000724 | Not Cancer Driver | No | 103 | 0.103 | 293 | 31 | 0.106 | 2 |
| UBE2N | UBE2N | P61088 | Ubiquitin-conjugating enzyme E2 N | chr12 | GO:0000724 | Not Cancer Driver | No | 25 | 0.164 | 24 | 3 | 0.125 | 0 |
| WDR48 | WDR48 | Q8TAF3 | WD repeat-containing protein 48 | chr3 | GO:0000724 | Not Cancer Driver | No | 61 | 0.09 | 125 | 19 | 0.152 | 0 |
| WRN | WRN | Q14191 | Werner syndrome ATP-dependent helicase | chr8 | GO:0000724 | Census, Compendium | Yes | 164 | 0.115 | 373 | 41 | 0.11 | 2 |
| XRCC1 | XRCC1 | P18887 | DNA repair protein XRCC1 | chr19 | GO:0000724 | Not Cancer Driver | No | 85 | 0.134 | 426 | 53 | 0.124 | 1 |
| XRCC2 | XRCC2 | O43543 | DNA repair protein XRCC2 | chr7 | GO:0000724 | Not Cancer Driver | No | 36 | 0.129 | 9 | 1 | 0.111 | 2 |
| XRCC3_ENST00000352127 | XRCC3 | O43542 | DNA repair protein XRCC3 | chr14 | GO:0000724 | Not Cancer Driver | No | 24 | 0.069 | 35 | 2 | 0.057 | 1 |
| YY1 | YY1 | P25490 | Transcriptional repressor protein YY1 | chr14 | GO:0000724 | Not Cancer Driver | No | 37 | 0.089 | 336 | 26 | 0.077 | 2 |
| ZFYVE26 | ZFYVE26 | Q68DK2 | Zinc finger FYVE domain-containing protein 26 | chr14 | GO:0000724 | Not Cancer Driver | No | 307 | 0.121 | 561 | 71 | 0.127 | 0 |
| ZSWIM7_ENST00000472495 | ZSWIM7 | Q19AV6 | Zinc finger SWIM domain-containing protein 7 | chr17 | GO:0000724 | Not Cancer Driver | No | 8 | 0.057 | 0 | 0 | 0.0 | 0 |