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Total number of protein in "GO:0000723" GO term:  58

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
ACD_ENST00000620761 ACD Q96AP0 Adrenocortical dysplasia protein homolog chr16 GO:0000723 Not Cancer Driver No 49 0.107 256 34 0.133 1
APEX1_ENST00000555414 APEX1 P27695 DNA-(apurinic or apyrimidinic site) endonuclease chr14 GO:0000723 Not Cancer Driver No 34 0.107 103 14 0.136 0
ATM_ENST00000452508 ATM Q13315 Serine-protein kinase ATM chr11 GO:0000723 Census, Compendium Yes 469 0.153 225 39 0.173 41
ATR ATR Q13535 Serine/threonine-protein kinase ATR chr3 GO:0000723 Census, Compendium Yes 338 0.128 106 14 0.132 1
BLM BLM P54132 Bloom syndrome protein chr15 GO:0000723 Census Yes 153 0.108 667 70 0.105 8
BRCA2_ENST00000544455 BRCA2 P51587 Breast cancer type 2 susceptibility protein chr13 GO:0000723 Census, Compendium Yes 457 0.134 1542 225 0.146 46
CCNE1 CCNE1 P24864 G1/S-specific cyclin-E1 chr19 GO:0000723 Census Yes 63 0.154 142 26 0.183 0
CCNE2_ENST00000308108 CCNE2 O96020 G1/S-specific cyclin-E2 chr8 GO:0000723 Not Cancer Driver No 46 0.114 68 9 0.132 0
CTC1 CTC1 Q2NKJ3 CST complex subunit CTC1 chr17 GO:0000723 Not Cancer Driver No 142 0.117 103 8 0.078 9
DCLRE1A DCLRE1A Q6PJP8 DNA cross-link repair 1A protein chr10 GO:0000723 Not Cancer Driver No 92 0.088 514 45 0.088 0
DCLRE1B DCLRE1B Q9H816 5' exonuclease Apollo chr1 GO:0000723 Not Cancer Driver No 65 0.122 127 17 0.134 0
DCLRE1C DCLRE1C Q96SD1 Protein artemis chr10 GO:0000723 Not Cancer Driver No 76 0.11 277 26 0.094 3
DNA2 DNA2 P51530 DNA replication ATP-dependent helicase/nuclease DNA2 chr10 GO:0000723 Not Cancer Driver No 120 0.113 52 8 0.154 3
ERCC1_ENST00000589165 ERCC1 P07992 DNA excision repair protein ERCC-1 chr19 GO:0000723 Not Cancer Driver No 42 0.141 105 14 0.133 1
ERCC4 ERCC4 Q92889 DNA repair endonuclease XPF chr16 GO:0000723 Census Yes 120 0.131 225 27 0.12 15
FEN1 FEN1 P39748 Flap endonuclease 1 chr11 GO:0000723 Census Yes 35 0.092 111 11 0.099 0
HUS1 HUS1 O60921 Checkpoint protein HUS1 chr7 GO:0000723 Not Cancer Driver No 25 0.089 17 2 0.118 0
HUS1B HUS1B Q8NHY5 Checkpoint protein HUS1B chr6 GO:0000723 Not Cancer Driver No 50 0.18 10 1 0.1 0
LTO1 LTO1 Q8WV07 Protein LTO1 homolog chr11 GO:0000723 Not Cancer Driver No 20 0.146 12 0 0.0 0
MRE11 MRE11 P49959 Double-strand break repair protein MRE11 chr11 GO:0000723 Not Cancer Driver No 84 0.119 292 35 0.12 1
NBN NBN O60934 Nibrin chr8 GO:0000723 Census Yes 90 0.119 417 54 0.129 1
NSMCE2_ENST00000522563 NSMCE2 Q96MF7 E3 SUMO-protein ligase NSE2 chr8 GO:0000723 Not Cancer Driver No 30 0.121 119 12 0.101 0
PARP1 PARP1 P09874 Poly [ADP-ribose] polymerase 1 chr1 GO:0000723 Not Cancer Driver No 119 0.117 320 34 0.106 0
PARP3_ENST00000431474 PARP3 Q9Y6F1 Protein mono-ADP-ribosyltransferase PARP3 chr3 GO:0000723 Not Cancer Driver No 70 0.131 269 38 0.141 0
PCNA PCNA P12004 Proliferating cell nuclear antigen chr20 GO:0000723 Not Cancer Driver No 30 0.115 22 3 0.136 1
POT1 POT1 Q9NUX5 Protection of telomeres protein 1 chr7 GO:0000723 Census, Compendium Yes 113 0.178 31 6 0.194 9
PRKDC PRKDC P78527 DNA-dependent protein kinase catalytic subunit chr8 GO:0000723 Not Cancer Driver No 538 0.13 421 61 0.145 2
PTGES3_ENST00000262033 PTGES3 Q15185 Prostaglandin E synthase 3 chr12 GO:0000723 Not Cancer Driver No 11 0.069 52 3 0.058 0
RAD50 RAD50 Q92878 DNA repair protein RAD50 chr5 GO:0000723 Not Cancer Driver No 157 0.12 730 84 0.115 0
RAD51C RAD51C O43502 DNA repair protein RAD51 homolog 3 chr17 GO:0000723 Not Cancer Driver No 47 0.125 18 2 0.111 6
RAD51D_ENST00000394589 RAD51D O75771 DNA repair protein RAD51 homolog 4 chr17 GO:0000723 Not Cancer Driver No 34 0.104 49 10 0.204 0
RAD51_ENST00000267868 RAD51 Q06609 DNA repair protein RAD51 homolog 1 chr15 GO:0000723 Not Cancer Driver No 42 0.124 47 5 0.106 3
RECQL4 RECQL4 O94761 ATP-dependent DNA helicase Q4 chr8 GO:0000723 Census, Compendium Yes 138 0.114 608 71 0.117 1
RIF1 RIF1 Q5UIP0 Telomere-associated protein RIF1 chr2 GO:0000723 Not Cancer Driver No 287 0.116 1355 164 0.121 0
RPA1 RPA1 P27694 Replication protein A 70 kDa DNA-binding subunit chr17 GO:0000723 Not Cancer Driver No 51 0.083 98 6 0.061 0
RPA2_ENST00000373912 RPA2 P15927 Replication protein A 32 kDa subunit chr1 GO:0000723 Not Cancer Driver No 28 0.104 114 16 0.14 0
RPA3 RPA3 P35244 Replication protein A 14 kDa subunit chr7 GO:0000723 Not Cancer Driver No 13 0.107 4 1 0.25 0
RTEL1_ENST00000370018 RTEL1 Q9NZ71 Regulator of telomere elongation helicase 1 chr20 GO:0000723 Not Cancer Driver No 144 0.118 474 64 0.135 14
SLX1B SLX1B Q9BQ83 Structure-specific endonuclease subunit SLX1 chr16 GO:0000723 Not Cancer Driver No 3 0.011 80 1 0.013 0
SLX4 SLX4 Q8IY92 Structure-specific endonuclease subunit SLX4 chr16 GO:0000723 Not Cancer Driver No 271 0.148 1573 232 0.147 0
SMC5 SMC5 Q8IY18 Structural maintenance of chromosomes protein 5 chr9 GO:0000723 Not Cancer Driver No 126 0.114 378 43 0.114 0
SMC6_ENST00000351948 SMC6 Q96SB8 Structural maintenance of chromosomes protein 6 chr2 GO:0000723 Not Cancer Driver No 128 0.117 458 57 0.124 0
SP100_ENST00000264052 SP100 P23497 Nuclear autoantigen Sp-100 chr2 GO:0000723 Not Cancer Driver No 136 0.155 680 101 0.149 0
STN1 STN1 Q9H668 CST complex subunit STN1 chr10 GO:0000723 Not Cancer Driver No 41 0.111 27 2 0.074 2
TEP1 TEP1 Q99973 Telomerase protein component 1 chr14 GO:0000723 Not Cancer Driver No 332 0.126 396 67 0.169 0
TERF1 TERF1 P54274 Telomeric repeat-binding factor 1 chr8 GO:0000723 Not Cancer Driver No 63 0.144 220 34 0.155 0
TERF2 TERF2 Q15554 Telomeric repeat-binding factor 2 chr16 GO:0000723 Not Cancer Driver No 33 0.061 361 20 0.055 0
TERF2IP TERF2IP Q9NYB0 Telomeric repeat-binding factor 2-interacting protein 1 chr16 GO:0000723 Not Cancer Driver No 28 0.07 310 16 0.052 0
TERT TERT O14746 Telomerase reverse transcriptase chr5 GO:0000723 Census Yes 110 0.097 212 16 0.075 31
TFIP11_ENST00000407148 TFIP11 Q9UBB9 Tuftelin-interacting protein 11 chr22 GO:0000723 Not Cancer Driver No 87 0.104 331 39 0.118 0
TPRKB_ENST00000272424 TPRKB Q9Y3C4 EKC/KEOPS complex subunit TPRKB chr2 GO:0000723 Not Cancer Driver No 20 0.114 0 0 0.0 2
UPF1 UPF1 Q92900 Regulator of nonsense transcripts 1 chr19 GO:0000723 Not Cancer Driver No 146 0.129 329 36 0.109 0
WRN WRN Q14191 Werner syndrome ATP-dependent helicase chr8 GO:0000723 Census, Compendium Yes 164 0.115 373 41 0.11 2
XRCC1 XRCC1 P18887 DNA repair protein XRCC1 chr19 GO:0000723 Not Cancer Driver No 85 0.134 426 53 0.124 1
XRCC3_ENST00000352127 XRCC3 O43542 DNA repair protein XRCC3 chr14 GO:0000723 Not Cancer Driver No 24 0.069 35 2 0.057 1
XRCC5_ENST00000392132 XRCC5 P13010 X-ray repair cross-complementing protein 5 chr2 GO:0000723 Not Cancer Driver No 87 0.119 118 11 0.093 0
XRCC6 XRCC6 P12956 X-ray repair cross-complementing protein 6 chr22 GO:0000723 Not Cancer Driver No 66 0.108 140 12 0.086 0
ZNF827 ZNF827 Q17R98 Zinc finger protein 827 chr4 GO:0000723 Not Cancer Driver No 158 0.146 754 123 0.163 0