Total number of protein in "GO:2001237" GO term: 95
| Identifier | UniProt Gene | UniProt Accession | UniProt Name | Chromosome | GO term | Database | Cancer Driver | Number of missense mutations | Missense mutation per residues | Number of disordered residues | Number of mutations in disordered regions | Disordered missense mutations per residues | Number of OMIM mutation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ACVR1_ENST00000434821 | ACVR1 | Q04771 | Activin receptor type-1 | chr2 | GO:2001237 | Census, Compendium | Yes | 78 | 0.153 | 21 | 8 | 0.381 | 8 |
| AKT1_ENST00000349310 | AKT1 | P31749 | RAC-alpha serine/threonine-protein kinase | chr14 | GO:2001237 | Census, Compendium | Yes | 108 | 0.225 | 158 | 24 | 0.152 | 4 |
| AR | AR | P10275 | Androgen receptor | chrX | GO:2001237 | Census, Compendium | Yes | 196 | 0.213 | 443 | 88 | 0.199 | 169 |
| ARHGEF2 | ARHGEF2 | Q92974 | Rho guanine nucleotide exchange factor 2 | chr1 | GO:2001237 | Not Cancer Driver | No | 146 | 0.148 | 450 | 70 | 0.156 | 0 |
| BCL2L1 | BCL2L1 | Q07817 | Bcl-2-like protein 1 | chr20 | GO:2001237 | Not Cancer Driver | No | 29 | 0.124 | 55 | 3 | 0.055 | 0 |
| BCL2_ENST00000333681 | BCL2 | P10415 | Apoptosis regulator Bcl-2 | chr18 | GO:2001237 | Census, Compendium | Yes | 24 | 0.1 | 72 | 5 | 0.069 | 0 |
| BIRC6 | BIRC6 | Q9NR09 | Baculoviral IAP repeat-containing protein 6 | chr2 | GO:2001237 | Census, Compendium | Yes | 640 | 0.132 | 1312 | 170 | 0.13 | 0 |
| BMP4 | BMP4 | P12644 | Bone morphogenetic protein 4 | chr14 | GO:2001237 | Not Cancer Driver | No | 86 | 0.211 | 142 | 26 | 0.183 | 5 |
| BMP5 | BMP5 | P22003 | Bone morphogenetic protein 5 | chr6 | GO:2001237 | Census | Yes | 163 | 0.359 | 112 | 62 | 0.554 | 0 |
| BRCA1_ENST00000357654 | BRCA1 | P38398 | Breast cancer type 1 susceptibility protein | chr17 | GO:2001237 | Census, Compendium | Yes | 224 | 0.12 | 1458 | 174 | 0.119 | 35 |
| CFLAR | CFLAR | O15519 | CASP8 and FADD-like apoptosis regulator | chr2 | GO:2001237 | Not Cancer Driver | No | 40 | 0.083 | 44 | 2 | 0.045 | 0 |
| COL2A1 | COL2A1 | P02458 | Collagen alpha-1(II) chain | chr12 | GO:2001237 | Census | Yes | 258 | 0.174 | 1215 | 207 | 0.17 | 64 |
| CSF2 | CSF2 | P04141 | Granulocyte-macrophage colony-stimulating factor | chr5 | GO:2001237 | Not Cancer Driver | No | 11 | 0.076 | 34 | 3 | 0.088 | 0 |
| CTNNA1 | CTNNA1 | P35221 | Catenin alpha-1 | chr5 | GO:2001237 | Census | Yes | 126 | 0.139 | 268 | 35 | 0.131 | 4 |
| CTTN_ENST00000301843 | CTTN | Q14247 | Src substrate cortactin | chr11 | GO:2001237 | Not Cancer Driver | No | 78 | 0.142 | 465 | 56 | 0.12 | 0 |
| CX3CL1 | CX3CL1 | P78423 | Fractalkine | chr16 | GO:2001237 | Not Cancer Driver | No | 66 | 0.166 | 259 | 44 | 0.17 | 0 |
| DDX3X_ENST00000629496 | DDX3X | O00571 | ATP-dependent RNA helicase DDX3X | chrX | GO:2001237 | Census, Compendium | Yes | 133 | 0.201 | 301 | 47 | 0.156 | 18 |
| EYA1_ENST00000647540 | EYA1 | Q99502 | Eyes absent homolog 1 | chr8 | GO:2001237 | Not Cancer Driver | No | 168 | 0.284 | 341 | 99 | 0.29 | 15 |
| EYA2 | EYA2 | O00167 | Eyes absent homolog 2 | chr20 | GO:2001237 | Not Cancer Driver | No | 107 | 0.199 | 204 | 50 | 0.245 | 0 |
| EYA3 | EYA3 | Q99504 | Eyes absent homolog 3 | chr1 | GO:2001237 | Not Cancer Driver | No | 58 | 0.101 | 310 | 40 | 0.129 | 0 |
| EYA4_ENST00000367895 | EYA4 | O95677 | Eyes absent homolog 4 | chr6 | GO:2001237 | Not Cancer Driver | No | 183 | 0.286 | 337 | 108 | 0.32 | 2 |
| FAIM2 | FAIM2 | Q9BWQ8 | Protein lifeguard 2 | chr12 | GO:2001237 | Not Cancer Driver | No | 37 | 0.117 | 54 | 11 | 0.204 | 0 |
| FAIM_ENST00000393035 | FAIM | Q9NVQ4 | Fas apoptotic inhibitory molecule 1 | chr3 | GO:2001237 | Not Cancer Driver | No | 20 | 0.112 | 1 | 0 | 0.0 | 0 |
| FGA | FGA | P02671 | Fibrinogen alpha chain | chr4 | GO:2001237 | Not Cancer Driver | No | 245 | 0.283 | 522 | 149 | 0.285 | 7 |
| FGB | FGB | P02675 | Fibrinogen beta chain | chr4 | GO:2001237 | Not Cancer Driver | No | 89 | 0.181 | 143 | 29 | 0.203 | 7 |
| FGF10 | FGF10 | O15520 | Fibroblast growth factor 10 | chr5 | GO:2001237 | Not Cancer Driver | No | 56 | 0.269 | 34 | 11 | 0.324 | 2 |
| FGG | FGG | P02679 | Fibrinogen gamma chain | chr4 | GO:2001237 | Not Cancer Driver | No | 81 | 0.179 | 53 | 8 | 0.151 | 8 |
| GATA1 | GATA1 | P15976 | Erythroid transcription factor | chrX | GO:2001237 | Census, Compendium | Yes | 68 | 0.165 | 242 | 41 | 0.169 | 5 |
| GCLC | GCLC | P48506 | Glutamate--cysteine ligase catalytic subunit | chr6 | GO:2001237 | Not Cancer Driver | No | 73 | 0.115 | 167 | 18 | 0.108 | 3 |
| GCLM | GCLM | P48507 | Glutamate--cysteine ligase regulatory subunit | chr1 | GO:2001237 | Not Cancer Driver | No | 32 | 0.117 | 31 | 3 | 0.097 | 0 |
| GDNF_ENST00000326524 | GDNF | P39905 | Glial cell line-derived neurotrophic factor | chr5 | GO:2001237 | Not Cancer Driver | No | 47 | 0.223 | 83 | 18 | 0.217 | 2 |
| GFRAL | GFRAL | Q6UXV0 | GDNF family receptor alpha-like | chr6 | GO:2001237 | Not Cancer Driver | No | 176 | 0.447 | 5 | 2 | 0.4 | 0 |
| GPX1_ENST00000620890 | GPX1 | P07203 | Glutathione peroxidase 1 | chr3 | GO:2001237 | Not Cancer Driver | No | 38 | 0.187 | 12 | 1 | 0.083 | 0 |
| GSK3B_ENST00000264235 | GSK3B | P49841 | Glycogen synthase kinase-3 beta | chr3 | GO:2001237 | Not Cancer Driver | No | 56 | 0.133 | 146 | 13 | 0.089 | 0 |
| GSTP1_ENST00000642444 | GSTP1 | P09211 | Glutathione S-transferase P | chr11 | GO:2001237 | Not Cancer Driver | No | 32 | 0.152 | 0 | 0 | 0.0 | 0 |
| HGF_ENST00000644543 | HGF | P14210 | Hepatocyte growth factor | chr7 | GO:2001237 | Compendium | Yes | 233 | 0.32 | 43 | 16 | 0.372 | 0 |
| HMGB2 | HMGB2 | P26583 | High mobility group protein B2 | chr4 | GO:2001237 | Not Cancer Driver | No | 38 | 0.182 | 207 | 38 | 0.184 | 0 |
| HMOX1 | HMOX1 | P09601 | Heme oxygenase 1 | chr22 | GO:2001237 | Not Cancer Driver | No | 46 | 0.16 | 81 | 13 | 0.16 | 0 |
| HSPA1A | HSPA1A | P0DMV8 | Heat shock 70 kDa protein 1A | chr6 | GO:2001237 | Not Cancer Driver | No | 24 | 0.037 | 200 | 13 | 0.065 | 0 |
| HSPA1B | HSPA1B | P0DMV9 | Heat shock 70 kDa protein 1B | chr6 | GO:2001237 | Not Cancer Driver | No | 15 | 0.023 | 200 | 5 | 0.025 | 0 |
| HTT | HTT | P42858 | Huntingtin | chr4 | GO:2001237 | Not Cancer Driver | No | 336 | 0.107 | 666 | 69 | 0.104 | 2 |
| ICAM1 | ICAM1 | P05362 | Intercellular adhesion molecule 1 | chr19 | GO:2001237 | Not Cancer Driver | No | 61 | 0.115 | 251 | 28 | 0.112 | 0 |
| IFI6_ENST00000361157 | IFI6 | P09912 | Interferon alpha-inducible protein 6 | chr1 | GO:2001237 | Not Cancer Driver | No | 12 | 0.092 | 7 | 0 | 0.0 | 0 |
| IGF1_ENST00000307046 | IGF1 | P05019 | Insulin-like growth factor I | chr12 | GO:2001237 | Not Cancer Driver | No | 45 | 0.231 | 87 | 23 | 0.264 | 0 |
| IL19_ENST00000270218 | IL19 | Q9UHD0 | Interleukin-19 | chr1 | GO:2001237 | Not Cancer Driver | No | 16 | 0.09 | 0 | 0 | 0.0 | 0 |
| IL1A | IL1A | P01583 | Interleukin-1 alpha | chr2 | GO:2001237 | Not Cancer Driver | No | 30 | 0.111 | 35 | 6 | 0.171 | 0 |
| IL1B | IL1B | P01584 | Interleukin-1 beta | chr2 | GO:2001237 | Not Cancer Driver | No | 39 | 0.145 | 16 | 3 | 0.188 | 0 |
| IL4 | IL4 | P05112 | Interleukin-4 | chr5 | GO:2001237 | Not Cancer Driver | No | 18 | 0.118 | 0 | 0 | 0.0 | 0 |
| IL7 | IL7 | P13232 | Interleukin-7 | chr8 | GO:2001237 | Not Cancer Driver | No | 29 | 0.164 | 19 | 4 | 0.211 | 0 |
| ITGA6_ENST00000442250 | ITGA6 | P23229 | Integrin alpha-6 | chr2 | GO:2001237 | Not Cancer Driver | No | 130 | 0.115 | 226 | 29 | 0.128 | 0 |
| ITGAV | ITGAV | P06756 | Integrin alpha-V | chr2 | GO:2001237 | Census | Yes | 153 | 0.146 | 92 | 9 | 0.098 | 0 |
| ITPRIP_ENST00000358187 | ITPRIP | Q8IWB1 | Inositol 1,4,5-trisphosphate receptor-interacting protein | chr10 | GO:2001237 | Not Cancer Driver | No | 62 | 0.113 | 66 | 10 | 0.152 | 0 |
| LGALS3 | LGALS3 | P17931 | Galectin-3 | chr14 | GO:2001237 | Not Cancer Driver | No | 15 | 0.06 | 133 | 6 | 0.045 | 0 |
| LMNA | LMNA | P02545 | Prelamin-A/C | chr1 | GO:2001237 | Census | Yes | 68 | 0.102 | 544 | 49 | 0.09 | 131 |
| MAP2K5 | MAP2K5 | Q13163 | Dual specificity mitogen-activated protein kinase kinase 5 | chr15 | GO:2001237 | Not Cancer Driver | No | 40 | 0.089 | 85 | 10 | 0.118 | 0 |
| MAPK7 | MAPK7 | Q13164 | Mitogen-activated protein kinase 7 | chr17 | GO:2001237 | Not Cancer Driver | No | 92 | 0.113 | 490 | 50 | 0.102 | 0 |
| MCL1 | MCL1 | Q07820 | Induced myeloid leukemia cell differentiation protein Mcl-1 | chr1 | GO:2001237 | Not Cancer Driver | No | 30 | 0.086 | 203 | 21 | 0.103 | 0 |
| NOL3_ENST00000268605 | NOL3 | O60936 | Nucleolar protein 3 | chr16 | GO:2001237 | Not Cancer Driver | No | 20 | 0.096 | 179 | 17 | 0.095 | 2 |
| NOS3 | NOS3 | P29474 | Nitric oxide synthase, endothelial | chr7 | GO:2001237 | Not Cancer Driver | No | 168 | 0.14 | 347 | 38 | 0.11 | 0 |
| NRP1 | NRP1 | O14786 | Neuropilin-1 | chr10 | GO:2001237 | Compendium | Yes | 146 | 0.158 | 211 | 31 | 0.147 | 0 |
| PAK5 | PAK5 | Q9P286 | Serine/threonine-protein kinase PAK 5 | chr20 | GO:2001237 | Not Cancer Driver | No | 226 | 0.314 | 407 | 123 | 0.302 | 0 |
| PARK7_ENST00000377488 | PARK7 | Q99497 | Parkinson disease protein 7 | chr1 | GO:2001237 | Not Cancer Driver | No | 11 | 0.058 | 30 | 0 | 0.0 | 5 |
| PEA15_ENST00000360472 | PEA15 | Q15121 | Astrocytic phosphoprotein PEA-15 | chr1 | GO:2001237 | Not Cancer Driver | No | 12 | 0.092 | 35 | 5 | 0.143 | 0 |
| PELI3 | PELI3 | Q8N2H9 | E3 ubiquitin-protein ligase pellino homolog 3 | chr11 | GO:2001237 | Not Cancer Driver | No | 48 | 0.102 | 216 | 25 | 0.116 | 0 |
| PF4 | PF4 | P02776 | Platelet factor 4 | chr4 | GO:2001237 | Not Cancer Driver | No | 13 | 0.129 | 0 | 0 | 0.0 | 0 |
| PHIP | PHIP | Q8WWQ0 | PH-interacting protein | chr6 | GO:2001237 | Not Cancer Driver | No | 239 | 0.131 | 835 | 110 | 0.132 | 0 |
| PRDX2 | PRDX2 | P32119 | Peroxiredoxin-2 | chr19 | GO:2001237 | Not Cancer Driver | No | 24 | 0.121 | 30 | 4 | 0.133 | 0 |
| PSME3_ENST00000590720 | PSME3 | P61289 | Proteasome activator complex subunit 3 | chr17 | GO:2001237 | Not Cancer Driver | No | 20 | 0.079 | 25 | 5 | 0.2 | 0 |
| RAF1 | RAF1 | P04049 | RAF proto-oncogene serine/threonine-protein kinase | chr3 | GO:2001237 | Census, Compendium | Yes | 89 | 0.137 | 169 | 38 | 0.225 | 22 |
| RB1CC1 | RB1CC1 | Q8TDY2 | RB1-inducible coiled-coil protein 1 | chr8 | GO:2001237 | Not Cancer Driver | No | 202 | 0.127 | 578 | 75 | 0.13 | 0 |
| RELA | RELA | Q04206 | Transcription factor p65 | chr11 | GO:2001237 | Compendium | Yes | 75 | 0.136 | 400 | 48 | 0.12 | 0 |
| RFFL_ENST00000394597 | RFFL | Q8WZ73 | E3 ubiquitin-protein ligase rififylin | chr17 | GO:2001237 | Not Cancer Driver | No | 50 | 0.138 | 150 | 21 | 0.14 | 0 |
| RIPK1_ENST00000380409 | RIPK1 | Q13546 | Receptor-interacting serine/threonine-protein kinase 1 | chr6 | GO:2001237 | Compendium | Yes | 82 | 0.122 | 277 | 39 | 0.141 | 4 |
| RNF34_ENST00000361234 | RNF34 | Q969K3 | E3 ubiquitin-protein ligase RNF34 | chr12 | GO:2001237 | Not Cancer Driver | No | 30 | 0.081 | 112 | 7 | 0.062 | 0 |
| RPS6KB1 | RPS6KB1 | P23443 | Ribosomal protein S6 kinase beta-1 | chr17 | GO:2001237 | Not Cancer Driver | No | 45 | 0.086 | 226 | 26 | 0.115 | 0 |
| SCG2 | SCG2 | P13521 | Secretogranin-2 | chr2 | GO:2001237 | Not Cancer Driver | No | 116 | 0.188 | 531 | 103 | 0.194 | 0 |
| SCRT2 | SCRT2 | Q9NQ03 | Transcriptional repressor scratch 2 | chr20 | GO:2001237 | Not Cancer Driver | No | 19 | 0.062 | 168 | 4 | 0.024 | 0 |
| SERPINE1 | SERPINE1 | P05121 | Plasminogen activator inhibitor 1 | chr7 | GO:2001237 | Not Cancer Driver | No | 78 | 0.194 | 7 | 2 | 0.286 | 0 |
| SFRP2 | SFRP2 | Q96HF1 | Secreted frizzled-related protein 2 | chr4 | GO:2001237 | Not Cancer Driver | No | 47 | 0.159 | 1 | 0 | 0.0 | 0 |
| SH3RF1 | SH3RF1 | Q7Z6J0 | E3 ubiquitin-protein ligase SH3RF1 | chr4 | GO:2001237 | Not Cancer Driver | No | 109 | 0.123 | 586 | 72 | 0.123 | 0 |
| SIAH2 | SIAH2 | O43255 | E3 ubiquitin-protein ligase SIAH2 | chr3 | GO:2001237 | Not Cancer Driver | No | 48 | 0.148 | 68 | 3 | 0.044 | 0 |
| SNAI2_ENST00000020945 | SNAI2 | O43623 | Zinc finger protein SNAI2 | chr8 | GO:2001237 | Not Cancer Driver | No | 52 | 0.194 | 52 | 9 | 0.173 | 0 |
| SRC_ENST00000358208 | SRC | P12931 | Proto-oncogene tyrosine-protein kinase Src | chr20 | GO:2001237 | Census | Yes | 53 | 0.099 | 130 | 11 | 0.085 | 1 |
| STRADB | STRADB | Q9C0K7 | STE20-related kinase adapter protein beta | chr2 | GO:2001237 | Not Cancer Driver | No | 53 | 0.127 | 84 | 7 | 0.083 | 0 |
| TCF7L2_ENST00000355995 | TCF7L2 | Q9NQB0 | Transcription factor 7-like 2 | chr10 | GO:2001237 | Census, Compendium | Yes | 122 | 0.197 | 516 | 93 | 0.18 | 0 |
| TERT | TERT | O14746 | Telomerase reverse transcriptase | chr5 | GO:2001237 | Census | Yes | 110 | 0.097 | 212 | 16 | 0.075 | 31 |
| TGFBR1_ENST00000374994 | TGFBR1 | P36897 | TGF-beta receptor type-1 | chr9 | GO:2001237 | Not Cancer Driver | No | 86 | 0.171 | 23 | 3 | 0.13 | 15 |
| THBS1 | THBS1 | P07996 | Thrombospondin-1 | chr15 | GO:2001237 | Not Cancer Driver | No | 188 | 0.161 | 320 | 58 | 0.181 | 0 |
| TMBIM1_ENST00000396809 | TMBIM1 | Q969X1 | Protein lifeguard 3 | chr2 | GO:2001237 | Not Cancer Driver | No | 30 | 0.096 | 83 | 8 | 0.096 | 0 |
| TNF | TNF | P01375 | Tumor necrosis factor | chr6 | GO:2001237 | Not Cancer Driver | No | 24 | 0.103 | 45 | 3 | 0.067 | 0 |
| TNFAIP3 | TNFAIP3 | P21580 | Tumor necrosis factor alpha-induced protein 3 | chr6 | GO:2001237 | Census, Compendium | Yes | 98 | 0.124 | 231 | 33 | 0.143 | 1 |
| UNC5B | UNC5B | Q8IZJ1 | Netrin receptor UNC5B | chr10 | GO:2001237 | Not Cancer Driver | No | 155 | 0.164 | 117 | 20 | 0.171 | 0 |
| YAP1_ENST00000282441 | YAP1 | P46937 | Transcriptional coactivator YAP1 | chr11 | GO:2001237 | Not Cancer Driver | No | 51 | 0.101 | 489 | 49 | 0.1 | 0 |
| ZC3HC1 | ZC3HC1 | Q86WB0 | Zinc finger C3HC-type protein 1 | chr7 | GO:2001237 | Not Cancer Driver | No | 70 | 0.139 | 250 | 34 | 0.136 | 0 |
| ZMYND11 | ZMYND11 | Q15326 | Zinc finger MYND domain-containing protein 11 | chr10 | GO:2001237 | Not Cancer Driver | No | 71 | 0.118 | 184 | 26 | 0.141 | 0 |