Total number of protein in "GO:2001236" GO term: 95
| Identifier | UniProt Gene | UniProt Accession | UniProt Name | Chromosome | GO term | Database | Cancer Driver | Number of missense mutations | Missense mutation per residues | Number of disordered residues | Number of mutations in disordered regions | Disordered missense mutations per residues | Number of OMIM mutation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKT1_ENST00000349310 | AKT1 | P31749 | RAC-alpha serine/threonine-protein kinase | chr14 | GO:2001236 | Census, Compendium | Yes | 108 | 0.225 | 158 | 24 | 0.152 | 4 |
| ARHGEF2 | ARHGEF2 | Q92974 | Rho guanine nucleotide exchange factor 2 | chr1 | GO:2001236 | Not Cancer Driver | No | 146 | 0.148 | 450 | 70 | 0.156 | 0 |
| ATF3_ENST00000366987 | ATF3 | P18847 | Cyclic AMP-dependent transcription factor ATF-3 | chr1 | GO:2001236 | Not Cancer Driver | No | 23 | 0.127 | 118 | 14 | 0.119 | 0 |
| BCL2L1 | BCL2L1 | Q07817 | Bcl-2-like protein 1 | chr20 | GO:2001236 | Not Cancer Driver | No | 29 | 0.124 | 55 | 3 | 0.055 | 0 |
| BCL2L12 | BCL2L12 | Q9HB09 | Bcl-2-like protein 12 | chr19 | GO:2001236 | Census, Compendium | Yes | 40 | 0.12 | 132 | 10 | 0.076 | 0 |
| BCL2L14 | BCL2L14 | Q9BZR8 | Apoptosis facilitator Bcl-2-like protein 14 | chr12 | GO:2001236 | Not Cancer Driver | No | 29 | 0.089 | 40 | 4 | 0.1 | 0 |
| BCL2_ENST00000333681 | BCL2 | P10415 | Apoptosis regulator Bcl-2 | chr18 | GO:2001236 | Census, Compendium | Yes | 24 | 0.1 | 72 | 5 | 0.069 | 0 |
| BMP5 | BMP5 | P22003 | Bone morphogenetic protein 5 | chr6 | GO:2001236 | Census | Yes | 163 | 0.359 | 112 | 62 | 0.554 | 0 |
| BMPR1B_ENST00000394931 | BMPR1B | O00238 | Bone morphogenetic protein receptor type-1B | chr4 | GO:2001236 | Not Cancer Driver | No | 84 | 0.167 | 64 | 12 | 0.188 | 5 |
| BRCA1_ENST00000357654 | BRCA1 | P38398 | Breast cancer type 1 susceptibility protein | chr17 | GO:2001236 | Census, Compendium | Yes | 224 | 0.12 | 1458 | 174 | 0.119 | 35 |
| CFLAR | CFLAR | O15519 | CASP8 and FADD-like apoptosis regulator | chr2 | GO:2001236 | Not Cancer Driver | No | 40 | 0.083 | 44 | 2 | 0.045 | 0 |
| COL2A1 | COL2A1 | P02458 | Collagen alpha-1(II) chain | chr12 | GO:2001236 | Census | Yes | 258 | 0.174 | 1215 | 207 | 0.17 | 64 |
| CSF2 | CSF2 | P04141 | Granulocyte-macrophage colony-stimulating factor | chr5 | GO:2001236 | Not Cancer Driver | No | 11 | 0.076 | 34 | 3 | 0.088 | 0 |
| CTNNA1 | CTNNA1 | P35221 | Catenin alpha-1 | chr5 | GO:2001236 | Census | Yes | 126 | 0.139 | 268 | 35 | 0.131 | 4 |
| CX3CL1 | CX3CL1 | P78423 | Fractalkine | chr16 | GO:2001236 | Not Cancer Driver | No | 66 | 0.166 | 259 | 44 | 0.17 | 0 |
| DBH | DBH | P09172 | Dopamine beta-hydroxylase | chr9 | GO:2001236 | Not Cancer Driver | No | 125 | 0.203 | 71 | 17 | 0.239 | 3 |
| DDX3X_ENST00000629496 | DDX3X | O00571 | ATP-dependent RNA helicase DDX3X | chrX | GO:2001236 | Census, Compendium | Yes | 133 | 0.201 | 301 | 47 | 0.156 | 18 |
| DEPTOR | DEPTOR | Q8TB45 | DEP domain-containing mTOR-interacting protein | chr8 | GO:2001236 | Not Cancer Driver | No | 57 | 0.139 | 125 | 12 | 0.096 | 0 |
| EYA1_ENST00000647540 | EYA1 | Q99502 | Eyes absent homolog 1 | chr8 | GO:2001236 | Not Cancer Driver | No | 168 | 0.284 | 341 | 99 | 0.29 | 15 |
| EYA2 | EYA2 | O00167 | Eyes absent homolog 2 | chr20 | GO:2001236 | Not Cancer Driver | No | 107 | 0.199 | 204 | 50 | 0.245 | 0 |
| EYA3 | EYA3 | Q99504 | Eyes absent homolog 3 | chr1 | GO:2001236 | Not Cancer Driver | No | 58 | 0.101 | 310 | 40 | 0.129 | 0 |
| EYA4_ENST00000367895 | EYA4 | O95677 | Eyes absent homolog 4 | chr6 | GO:2001236 | Not Cancer Driver | No | 183 | 0.286 | 337 | 108 | 0.32 | 2 |
| FAF1 | FAF1 | Q9UNN5 | FAS-associated factor 1 | chr1 | GO:2001236 | Not Cancer Driver | No | 83 | 0.128 | 241 | 34 | 0.141 | 0 |
| FAIM2 | FAIM2 | Q9BWQ8 | Protein lifeguard 2 | chr12 | GO:2001236 | Not Cancer Driver | No | 37 | 0.117 | 54 | 11 | 0.204 | 0 |
| FAIM_ENST00000393035 | FAIM | Q9NVQ4 | Fas apoptotic inhibitory molecule 1 | chr3 | GO:2001236 | Not Cancer Driver | No | 20 | 0.112 | 1 | 0 | 0.0 | 0 |
| FEM1B | FEM1B | Q9UK73 | Protein fem-1 homolog B | chr15 | GO:2001236 | Not Cancer Driver | No | 69 | 0.11 | 33 | 3 | 0.091 | 0 |
| FGA | FGA | P02671 | Fibrinogen alpha chain | chr4 | GO:2001236 | Not Cancer Driver | No | 245 | 0.283 | 522 | 149 | 0.285 | 7 |
| FGB | FGB | P02675 | Fibrinogen beta chain | chr4 | GO:2001236 | Not Cancer Driver | No | 89 | 0.181 | 143 | 29 | 0.203 | 7 |
| FGF10 | FGF10 | O15520 | Fibroblast growth factor 10 | chr5 | GO:2001236 | Not Cancer Driver | No | 56 | 0.269 | 34 | 11 | 0.324 | 2 |
| FGFR1_ENST00000447712 | FGFR1 | P11362 | Fibroblast growth factor receptor 1 | chr8 | GO:2001236 | Census, Compendium | Yes | 152 | 0.185 | 230 | 43 | 0.187 | 74 |
| FGG | FGG | P02679 | Fibrinogen gamma chain | chr4 | GO:2001236 | Not Cancer Driver | No | 81 | 0.179 | 53 | 8 | 0.151 | 8 |
| GATA1 | GATA1 | P15976 | Erythroid transcription factor | chrX | GO:2001236 | Census, Compendium | Yes | 68 | 0.165 | 242 | 41 | 0.169 | 5 |
| GDNF_ENST00000326524 | GDNF | P39905 | Glial cell line-derived neurotrophic factor | chr5 | GO:2001236 | Not Cancer Driver | No | 47 | 0.223 | 83 | 18 | 0.217 | 2 |
| GFRAL | GFRAL | Q6UXV0 | GDNF family receptor alpha-like | chr6 | GO:2001236 | Not Cancer Driver | No | 176 | 0.447 | 5 | 2 | 0.4 | 0 |
| GPX1_ENST00000620890 | GPX1 | P07203 | Glutathione peroxidase 1 | chr3 | GO:2001236 | Not Cancer Driver | No | 38 | 0.187 | 12 | 1 | 0.083 | 0 |
| GSK3B_ENST00000264235 | GSK3B | P49841 | Glycogen synthase kinase-3 beta | chr3 | GO:2001236 | Not Cancer Driver | No | 56 | 0.133 | 146 | 13 | 0.089 | 0 |
| HGF_ENST00000644543 | HGF | P14210 | Hepatocyte growth factor | chr7 | GO:2001236 | Compendium | Yes | 233 | 0.32 | 43 | 16 | 0.372 | 0 |
| HMGB2 | HMGB2 | P26583 | High mobility group protein B2 | chr4 | GO:2001236 | Not Cancer Driver | No | 38 | 0.182 | 207 | 38 | 0.184 | 0 |
| HMOX1 | HMOX1 | P09601 | Heme oxygenase 1 | chr22 | GO:2001236 | Not Cancer Driver | No | 46 | 0.16 | 81 | 13 | 0.16 | 0 |
| HSPA1A | HSPA1A | P0DMV8 | Heat shock 70 kDa protein 1A | chr6 | GO:2001236 | Not Cancer Driver | No | 24 | 0.037 | 200 | 13 | 0.065 | 0 |
| HSPA1B | HSPA1B | P0DMV9 | Heat shock 70 kDa protein 1B | chr6 | GO:2001236 | Not Cancer Driver | No | 15 | 0.023 | 200 | 5 | 0.025 | 0 |
| HTRA2 | HTRA2 | O43464 | Serine protease HTRA2, mitochondrial | chr2 | GO:2001236 | Compendium | Yes | 44 | 0.096 | 127 | 9 | 0.071 | 2 |
| ICAM1 | ICAM1 | P05362 | Intercellular adhesion molecule 1 | chr19 | GO:2001236 | Not Cancer Driver | No | 61 | 0.115 | 251 | 28 | 0.112 | 0 |
| IFI6_ENST00000361157 | IFI6 | P09912 | Interferon alpha-inducible protein 6 | chr1 | GO:2001236 | Not Cancer Driver | No | 12 | 0.092 | 7 | 0 | 0.0 | 0 |
| IL1A | IL1A | P01583 | Interleukin-1 alpha | chr2 | GO:2001236 | Not Cancer Driver | No | 30 | 0.111 | 35 | 6 | 0.171 | 0 |
| IL1B | IL1B | P01584 | Interleukin-1 beta | chr2 | GO:2001236 | Not Cancer Driver | No | 39 | 0.145 | 16 | 3 | 0.188 | 0 |
| IL7 | IL7 | P13232 | Interleukin-7 | chr8 | GO:2001236 | Not Cancer Driver | No | 29 | 0.164 | 19 | 4 | 0.211 | 0 |
| INHBA_ENST00000442711 | INHBA | P08476 | Inhibin beta A chain | chr7 | GO:2001236 | Not Cancer Driver | No | 148 | 0.347 | 154 | 63 | 0.409 | 0 |
| ITPRIP_ENST00000358187 | ITPRIP | Q8IWB1 | Inositol 1,4,5-trisphosphate receptor-interacting protein | chr10 | GO:2001236 | Not Cancer Driver | No | 62 | 0.113 | 66 | 10 | 0.152 | 0 |
| LGALS3 | LGALS3 | P17931 | Galectin-3 | chr14 | GO:2001236 | Not Cancer Driver | No | 15 | 0.06 | 133 | 6 | 0.045 | 0 |
| MADD | MADD | Q8WXG6 | MAP kinase-activating death domain protein | chr11 | GO:2001236 | Not Cancer Driver | No | 207 | 0.126 | 723 | 81 | 0.112 | 4 |
| MAL | MAL | P21145 | Myelin and lymphocyte protein | chr2 | GO:2001236 | Not Cancer Driver | No | 21 | 0.137 | 0 | 0 | 0.0 | 0 |
| MAP2K5 | MAP2K5 | Q13163 | Dual specificity mitogen-activated protein kinase kinase 5 | chr15 | GO:2001236 | Not Cancer Driver | No | 40 | 0.089 | 85 | 10 | 0.118 | 0 |
| MAPK7 | MAPK7 | Q13164 | Mitogen-activated protein kinase 7 | chr17 | GO:2001236 | Not Cancer Driver | No | 92 | 0.113 | 490 | 50 | 0.102 | 0 |
| MCL1 | MCL1 | Q07820 | Induced myeloid leukemia cell differentiation protein Mcl-1 | chr1 | GO:2001236 | Not Cancer Driver | No | 30 | 0.086 | 203 | 21 | 0.103 | 0 |
| NF1 | NF1 | P21359 | Neurofibromin | chr17 | GO:2001236 | Census, Compendium | Yes | 375 | 0.132 | 406 | 47 | 0.116 | 85 |
| NOS3 | NOS3 | P29474 | Nitric oxide synthase, endothelial | chr7 | GO:2001236 | Not Cancer Driver | No | 168 | 0.14 | 347 | 38 | 0.11 | 0 |
| PARK7_ENST00000377488 | PARK7 | Q99497 | Parkinson disease protein 7 | chr1 | GO:2001236 | Not Cancer Driver | No | 11 | 0.058 | 30 | 0 | 0.0 | 5 |
| PEA15_ENST00000360472 | PEA15 | Q15121 | Astrocytic phosphoprotein PEA-15 | chr1 | GO:2001236 | Not Cancer Driver | No | 12 | 0.092 | 35 | 5 | 0.143 | 0 |
| PF4 | PF4 | P02776 | Platelet factor 4 | chr4 | GO:2001236 | Not Cancer Driver | No | 13 | 0.129 | 0 | 0 | 0.0 | 0 |
| PMAIP1 | PMAIP1 | Q13794 | Phorbol-12-myristate-13-acetate-induced protein 1 | chr18 | GO:2001236 | Not Cancer Driver | No | 2 | 0.037 | 23 | 1 | 0.043 | 0 |
| PPP1CA_ENST00000376745 | PPP1CA | P62136 | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit | chr11 | GO:2001236 | Not Cancer Driver | No | 38 | 0.115 | 27 | 6 | 0.222 | 0 |
| PPP2R1A | PPP2R1A | P30153 | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform | chr19 | GO:2001236 | Census, Compendium | Yes | 179 | 0.304 | 0 | 0 | 0.0 | 4 |
| PPP2R1B_ENST00000527614 | PPP2R1B | P30154 | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform | chr11 | GO:2001236 | Not Cancer Driver | No | 72 | 0.12 | 17 | 1 | 0.059 | 0 |
| PRDX2 | PRDX2 | P32119 | Peroxiredoxin-2 | chr19 | GO:2001236 | Not Cancer Driver | No | 24 | 0.121 | 30 | 4 | 0.133 | 0 |
| PTEN | PTEN | P60484 | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN | chr10 | GO:2001236 | Census, Compendium | Yes | 505 | 1.253 | 76 | 4 | 0.053 | 41 |
| RAF1 | RAF1 | P04049 | RAF proto-oncogene serine/threonine-protein kinase | chr3 | GO:2001236 | Census, Compendium | Yes | 89 | 0.137 | 169 | 38 | 0.225 | 22 |
| RET | RET | P07949 | Proto-oncogene tyrosine-protein kinase receptor Ret | chr10 | GO:2001236 | Census, Compendium | Yes | 208 | 0.187 | 105 | 12 | 0.114 | 139 |
| RFFL_ENST00000394597 | RFFL | Q8WZ73 | E3 ubiquitin-protein ligase rififylin | chr17 | GO:2001236 | Not Cancer Driver | No | 50 | 0.138 | 150 | 21 | 0.14 | 0 |
| RIPK1_ENST00000380409 | RIPK1 | Q13546 | Receptor-interacting serine/threonine-protein kinase 1 | chr6 | GO:2001236 | Compendium | Yes | 82 | 0.122 | 277 | 39 | 0.141 | 4 |
| RNF34_ENST00000361234 | RNF34 | Q969K3 | E3 ubiquitin-protein ligase RNF34 | chr12 | GO:2001236 | Not Cancer Driver | No | 30 | 0.081 | 112 | 7 | 0.062 | 0 |
| SCRT2 | SCRT2 | Q9NQ03 | Transcriptional repressor scratch 2 | chr20 | GO:2001236 | Not Cancer Driver | No | 19 | 0.062 | 168 | 4 | 0.024 | 0 |
| SERPINE1 | SERPINE1 | P05121 | Plasminogen activator inhibitor 1 | chr7 | GO:2001236 | Not Cancer Driver | No | 78 | 0.194 | 7 | 2 | 0.286 | 0 |
| SFRP1 | SFRP1 | Q8N474 | Secreted frizzled-related protein 1 | chr8 | GO:2001236 | Not Cancer Driver | No | 40 | 0.127 | 39 | 7 | 0.179 | 0 |
| SFRP2 | SFRP2 | Q96HF1 | Secreted frizzled-related protein 2 | chr4 | GO:2001236 | Not Cancer Driver | No | 47 | 0.159 | 1 | 0 | 0.0 | 0 |
| SKIL_ENST00000259119 | SKIL | P12757 | Ski-like protein | chr3 | GO:2001236 | Not Cancer Driver | No | 77 | 0.113 | 356 | 32 | 0.09 | 0 |
| SNAI2_ENST00000020945 | SNAI2 | O43623 | Zinc finger protein SNAI2 | chr8 | GO:2001236 | Not Cancer Driver | No | 52 | 0.194 | 52 | 9 | 0.173 | 0 |
| SP100_ENST00000264052 | SP100 | P23497 | Nuclear autoantigen Sp-100 | chr2 | GO:2001236 | Not Cancer Driver | No | 136 | 0.155 | 680 | 101 | 0.149 | 0 |
| SRPX | SRPX | P78539 | Sushi repeat-containing protein SRPX | chrX | GO:2001236 | Not Cancer Driver | No | 71 | 0.153 | 60 | 10 | 0.167 | 0 |
| STK3_ENST00000419617 | STK3 | Q13188 | Serine/threonine-protein kinase 3 | chr8 | GO:2001236 | Not Cancer Driver | No | 70 | 0.143 | 241 | 32 | 0.133 | 0 |
| STK4 | STK4 | Q13043 | Serine/threonine-protein kinase 4 | chr20 | GO:2001236 | Not Cancer Driver | No | 70 | 0.144 | 231 | 30 | 0.13 | 0 |
| STRADB | STRADB | Q9C0K7 | STE20-related kinase adapter protein beta | chr2 | GO:2001236 | Not Cancer Driver | No | 53 | 0.127 | 84 | 7 | 0.083 | 0 |
| STX4 | STX4 | Q12846 | Syntaxin-4 | chr16 | GO:2001236 | Not Cancer Driver | No | 50 | 0.168 | 152 | 20 | 0.132 | 0 |
| TERT | TERT | O14746 | Telomerase reverse transcriptase | chr5 | GO:2001236 | Census | Yes | 110 | 0.097 | 212 | 16 | 0.075 | 31 |
| THBS1 | THBS1 | P07996 | Thrombospondin-1 | chr15 | GO:2001236 | Not Cancer Driver | No | 188 | 0.161 | 320 | 58 | 0.181 | 0 |
| TIMP3 | TIMP3 | P35625 | Metalloproteinase inhibitor 3 | chr22 | GO:2001236 | Not Cancer Driver | No | 43 | 0.204 | 3 | 1 | 0.333 | 5 |
| TMBIM1_ENST00000396809 | TMBIM1 | Q969X1 | Protein lifeguard 3 | chr2 | GO:2001236 | Not Cancer Driver | No | 30 | 0.096 | 83 | 8 | 0.096 | 0 |
| TMC8 | TMC8 | Q8IU68 | Transmembrane channel-like protein 8 | chr17 | GO:2001236 | Not Cancer Driver | No | 61 | 0.084 | 107 | 10 | 0.093 | 0 |
| TNF | TNF | P01375 | Tumor necrosis factor | chr6 | GO:2001236 | Not Cancer Driver | No | 24 | 0.103 | 45 | 3 | 0.067 | 0 |
| TNFAIP3 | TNFAIP3 | P21580 | Tumor necrosis factor alpha-induced protein 3 | chr6 | GO:2001236 | Census, Compendium | Yes | 98 | 0.124 | 231 | 33 | 0.143 | 1 |
| TRAF1 | TRAF1 | Q13077 | TNF receptor-associated factor 1 | chr9 | GO:2001236 | Not Cancer Driver | No | 51 | 0.123 | 63 | 9 | 0.143 | 0 |
| UNC5B | UNC5B | Q8IZJ1 | Netrin receptor UNC5B | chr10 | GO:2001236 | Not Cancer Driver | No | 155 | 0.164 | 117 | 20 | 0.171 | 0 |
| WWOX | WWOX | Q9NZC7 | WW domain-containing oxidoreductase | chr16 | GO:2001236 | Not Cancer Driver | No | 79 | 0.191 | 108 | 9 | 0.083 | 3 |
| ZC3HC1 | ZC3HC1 | Q86WB0 | Zinc finger C3HC-type protein 1 | chr7 | GO:2001236 | Not Cancer Driver | No | 70 | 0.139 | 250 | 34 | 0.136 | 0 |
| ZSWIM2 | ZSWIM2 | Q8NEG5 | E3 ubiquitin-protein ligase ZSWIM2 | chr2 | GO:2001236 | Not Cancer Driver | No | 189 | 0.299 | 85 | 30 | 0.353 | 0 |