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Total number of protein in "GO:2000377" GO term:  135

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
ABCB7_ENST00000373394 ABCB7 O75027 Iron-sulfur clusters transporter ABCB7, mitochondrial chrX GO:2000377 Not Cancer Driver No 117 0.156 79 14 0.177 4
ABCD1 ABCD1 P33897 ATP-binding cassette sub-family D member 1 chrX GO:2000377 Not Cancer Driver No 106 0.142 75 5 0.067 138
ABCD2 ABCD2 Q9UBJ2 ATP-binding cassette sub-family D member 2 chr12 GO:2000377 Not Cancer Driver No 150 0.203 29 4 0.138 0
ACE2 ACE2 Q9BYF1 Angiotensin-converting enzyme 2 chrX GO:2000377 Not Cancer Driver No 104 0.129 68 5 0.074 0
ACOD1 ACOD1 A6NK06 Cis-aconitate decarboxylase chr13 GO:2000377 Not Cancer Driver No 5 0.01 36 0 0.0 0
ACP5_ENST00000433365 ACP5 P13686 Tartrate-resistant acid phosphatase type 5 chr19 GO:2000377 Not Cancer Driver No 51 0.157 31 6 0.194 8
ADGRB1_ENST00000323289 ADGRB1 O14514 Adhesion G protein-coupled receptor B1 chr8 GO:2000377 Compendium Yes 213 0.134 485 47 0.097 0
AGT AGT P01019 Angiotensinogen chr1 GO:2000377 Not Cancer Driver No 85 0.179 33 10 0.303 1
AGTR1_ENST00000349243 AGTR1 P30556 Type-1 angiotensin II receptor chr3 GO:2000377 Not Cancer Driver No 95 0.265 0 0 0.0 1
AKR1C1 AKR1C1 Q04828 Aldo-keto reductase family 1 member C1 chr10 GO:2000377 Not Cancer Driver No 56 0.173 1 0 0.0 0
AKR1C3 AKR1C3 P42330 Aldo-keto reductase family 1 member C3 chr10 GO:2000377 Not Cancer Driver No 49 0.152 11 1 0.091 0
ALOX5 ALOX5 P09917 Polyunsaturated fatty acid 5-lipoxygenase chr10 GO:2000377 Not Cancer Driver No 129 0.191 16 2 0.125 0
APOPT1 COA8 Q96IL0 Cytochrome c oxidase assembly factor 8 chr14 GO:2000377 Not Cancer Driver No 23 0.112 48 4 0.083 0
ARF4 ARF4 P18085 ADP-ribosylation factor 4 chr3 GO:2000377 Not Cancer Driver No 17 0.094 0 0 0.0 0
ARG2 ARG2 P78540 Arginase-2, mitochondrial chr14 GO:2000377 Not Cancer Driver No 25 0.071 58 3 0.052 0
ATG5_ENST00000343245 ATG5 Q9H1Y0 Autophagy protein 5 chr6 GO:2000377 Not Cancer Driver No 40 0.145 25 6 0.24 1
BCL2_ENST00000333681 BCL2 P10415 Apoptosis regulator Bcl-2 chr18 GO:2000377 Census, Compendium Yes 24 0.1 72 5 0.069 0
BCO2 BCO2 Q9BYV7 Carotenoid-cleaving dioxygenase, mitochondrial chr11 GO:2000377 Not Cancer Driver No 79 0.136 14 1 0.071 0
BCR BCR P11274 Breakpoint cluster region protein chr22 GO:2000377 Census, Compendium Yes 146 0.115 603 69 0.114 0
BECN1_ENST00000590099 BECN1 Q14457 Beclin-1 chr17 GO:2000377 Not Cancer Driver No 45 0.1 190 19 0.1 0
BIRC2 BIRC2 Q13490 Baculoviral IAP repeat-containing protein 2 chr11 GO:2000377 Not Cancer Driver No 69 0.112 83 9 0.108 0
BMP7 BMP7 P18075 Bone morphogenetic protein 7 chr20 GO:2000377 Not Cancer Driver No 91 0.211 69 18 0.261 0
BRCA1_ENST00000357654 BRCA1 P38398 Breast cancer type 1 susceptibility protein chr17 GO:2000377 Census, Compendium Yes 224 0.12 1458 174 0.119 35
BST1 BST1 Q10588 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 chr4 GO:2000377 Not Cancer Driver No 40 0.126 11 0 0.0 0
CBR1 CBR1 P16152 Carbonyl reductase [NADPH] 1 chr21 GO:2000377 Not Cancer Driver No 27 0.097 62 11 0.177 0
CCN6_ENST00000230529 CCN6 O95389 Cellular communication network factor 6 chr6 GO:2000377 Not Cancer Driver No 39 0.11 11 0 0.0 9
CD177 CD177 Q8N6Q3 CD177 antigen chr19 GO:2000377 Not Cancer Driver No 71 0.162 79 26 0.329 0
CD36_ENST00000309881 CD36 P16671 Platelet glycoprotein 4 chr7 GO:2000377 Not Cancer Driver No 75 0.159 12 3 0.25 3
CDKN1A_ENST00000373711 CDKN1A P38936 Cyclin-dependent kinase inhibitor 1 chr6 GO:2000377 Census, Compendium Yes 48 0.293 121 30 0.248 0
CFLAR CFLAR O15519 CASP8 and FADD-like apoptosis regulator chr2 GO:2000377 Not Cancer Driver No 40 0.083 44 2 0.045 0
CLCN3_ENST00000513761 CLCN3 P51790 H(+)/Cl(-) exchange transporter 3 chr4 GO:2000377 Not Cancer Driver No 105 0.128 88 7 0.08 0
CLEC7A CLEC7A Q9BXN2 C-type lectin domain family 7 member A chr12 GO:2000377 Not Cancer Driver No 43 0.174 46 2 0.043 0
COQ7_ENST00000568985 COQ7 Q99807 5-demethoxyubiquinone hydroxylase, mitochondrial chr16 GO:2000377 Not Cancer Driver No 27 0.124 5 1 0.2 1
CRP CRP P02741 C-reactive protein chr1 GO:2000377 Not Cancer Driver No 59 0.263 0 0 0.0 0
CRYAB_ENST00000616970 CRYAB P02511 Alpha-crystallin B chain chr11 GO:2000377 Not Cancer Driver No 22 0.126 59 11 0.186 4
CTNS_ENST00000046640 CTNS O60931 Cystinosin chr17 GO:2000377 Not Cancer Driver No 34 0.093 0 0 0.0 31
CYBA CYBA P13498 Cytochrome b-245 light chain chr16 GO:2000377 Not Cancer Driver No 26 0.133 66 2 0.03 12
CYP1B1 CYP1B1 Q16678 Cytochrome P450 1B1 chr2 GO:2000377 Not Cancer Driver No 61 0.112 31 3 0.097 40
DCXR DCXR Q7Z4W1 L-xylulose reductase chr17 GO:2000377 Not Cancer Driver No 14 0.057 10 1 0.1 0
DHFR DHFR P00374 Dihydrofolate reductase chr5 GO:2000377 Not Cancer Driver No 16 0.086 12 2 0.167 2
DHRS4 DHRS4 Q9BTZ2 Dehydrogenase/reductase SDR family member 4 chr14 GO:2000377 Not Cancer Driver No 30 0.108 38 4 0.105 0
DUOXA1_ENST00000560572 DUOXA1 Q1HG43 Dual oxidase maturation factor 1 chr15 GO:2000377 Not Cancer Driver No 40 0.117 38 7 0.184 0
DUOXA2 DUOXA2 Q1HG44 Dual oxidase maturation factor 2 chr15 GO:2000377 Not Cancer Driver No 40 0.125 0 0 0.0 0
EIF6_ENST00000374436 EIF6 P56537 Eukaryotic translation initiation factor 6 chr20 GO:2000377 Not Cancer Driver No 30 0.122 17 3 0.176 0
F2 F2 P00734 Prothrombin chr11 GO:2000377 Not Cancer Driver No 115 0.185 97 25 0.258 10
F2RL1 F2RL1 P55085 Proteinase-activated receptor 2 chr5 GO:2000377 Not Cancer Driver No 55 0.139 7 2 0.286 0
FBLN5 FBLN5 Q9UBX5 Fibulin-5 chr14 GO:2000377 Not Cancer Driver No 77 0.172 11 2 0.182 16
FOXM1_ENST00000359843 FOXM1 Q08050 Forkhead box protein M1 chr12 GO:2000377 Not Cancer Driver No 97 0.127 601 73 0.121 0
FOXO1 FOXO1 Q12778 Forkhead box protein O1 chr13 GO:2000377 Census, Compendium Yes 81 0.124 584 75 0.128 0
FOXO3 FOXO3 O43524 Forkhead box protein O3 chr6 GO:2000377 Census, Compendium Yes 70 0.104 595 68 0.114 0
FPR2 FPR2 P25090 N-formyl peptide receptor 2 chr19 GO:2000377 Not Cancer Driver No 96 0.274 26 5 0.192 0
FYN FYN P06241 Tyrosine-protein kinase Fyn chr6 GO:2000377 Not Cancer Driver No 92 0.171 70 13 0.186 0
G6PD_ENST00000621232 G6PD P11413 Glucose-6-phosphate 1-dehydrogenase chrX GO:2000377 Not Cancer Driver No 86 0.167 28 3 0.107 58
GADD45A GADD45A P24522 Growth arrest and DNA damage-inducible protein GADD45 alpha chr1 GO:2000377 Not Cancer Driver No 10 0.061 39 5 0.128 0
GCH1_ENST00000622544 GCH1 P30793 GTP cyclohydrolase 1 chr14 GO:2000377 Not Cancer Driver No 20 0.08 99 5 0.051 38
GNAI2 GNAI2 P04899 Guanine nucleotide-binding protein G(i) subunit alpha-2 chr3 GO:2000377 Compendium Yes 50 0.141 24 0 0.0 0
GNAI3 GNAI3 P08754 Guanine nucleotide-binding protein G(i) subunit alpha-3 chr1 GO:2000377 Not Cancer Driver No 42 0.119 11 0 0.0 1
GRB2_ENST00000392564 GRB2 P62993 Growth factor receptor-bound protein 2 chr17 GO:2000377 Not Cancer Driver No 28 0.129 10 1 0.1 0
GRIN1_ENST00000371561 GRIN1 Q05586 Glutamate receptor ionotropic, NMDA 1 chr9 GO:2000377 Not Cancer Driver No 88 0.094 190 15 0.079 13
GSTP1_ENST00000642444 GSTP1 P09211 Glutathione S-transferase P chr11 GO:2000377 Not Cancer Driver No 32 0.152 0 0 0.0 0
HDAC6_ENST00000426196 HDAC6 Q9UBN7 Histone deacetylase 6 chrX GO:2000377 Not Cancer Driver No 178 0.147 409 59 0.144 0
HIF1A_ENST00000337138 HIF1A Q16665 Hypoxia-inducible factor 1-alpha chr14 GO:2000377 Census Yes 118 0.143 435 51 0.117 0
HK2 HK2 P52789 Hexokinase-2 chr2 GO:2000377 Not Cancer Driver No 138 0.15 77 7 0.091 0
HP HP P00738 Haptoglobin chr16 GO:2000377 Not Cancer Driver No 39 0.096 57 2 0.035 1
HVCN1_ENST00000620084 HVCN1 Q96D96 Voltage-gated hydrogen channel 1 chr12 GO:2000377 Not Cancer Driver No 51 0.187 52 13 0.25 0
INS INS P01308 Insulin chr11 GO:2000377 Not Cancer Driver No 15 0.136 5 1 0.2 22
ITGAM_ENST00000287497 ITGAM P11215 Integrin alpha-M chr16 GO:2000377 Not Cancer Driver No 191 0.166 133 12 0.09 0
ITGB2_ENST00000355153 ITGB2 P05107 Integrin beta-2 chr21 GO:2000377 Not Cancer Driver No 147 0.191 59 9 0.153 15
LEP LEP P41159 Leptin chr7 GO:2000377 Not Cancer Driver No 29 0.174 0 0 0.0 2
MAPK14_ENST00000229794 MAPK14 Q16539 Mitogen-activated protein kinase 14 chr6 GO:2000377 Not Cancer Driver No 39 0.108 25 1 0.04 0
MAPT_ENST00000262410 MAPT P10636 Microtubule-associated protein tau chr17 GO:2000377 Not Cancer Driver No 128 0.169 750 126 0.168 18
MMP3 MMP3 P08254 Stromelysin-1 chr11 GO:2000377 Not Cancer Driver No 99 0.208 66 14 0.212 0
MMP8 MMP8 P22894 Neutrophil collagenase chr11 GO:2000377 Not Cancer Driver No 73 0.156 115 19 0.165 0
MPV17 MPV17 P39210 Protein Mpv17 chr2 GO:2000377 Not Cancer Driver No 21 0.119 0 0 0.0 16
MPV17L MPV17L Q2QL34 Mpv17-like protein chr16 GO:2000377 Not Cancer Driver No 16 0.082 3 0 0.0 0
MT3 MT3 P25713 Metallothionein-3 chr16 GO:2000377 Not Cancer Driver No 7 0.103 0 0 0.0 0
NFE2L2 NFE2L2 Q16236 Nuclear factor erythroid 2-related factor 2 chr2 GO:2000377 Census, Compendium Yes 228 0.377 402 62 0.154 4
NOXA1 NOXA1 Q86UR1 NADPH oxidase activator 1 chr9 GO:2000377 Not Cancer Driver No 27 0.057 215 14 0.065 0
NOXO1 NOXO1 Q8NFA2 NADPH oxidase organizer 1 chr16 GO:2000377 Not Cancer Driver No 29 0.077 182 9 0.049 0
PAGE4_ENST00000376141 PAGE4 O60829 P antigen family member 4 chrX GO:2000377 Not Cancer Driver No 20 0.196 102 20 0.196 0
PARK7_ENST00000377488 PARK7 Q99497 Parkinson disease protein 7 chr1 GO:2000377 Not Cancer Driver No 11 0.058 30 0 0.0 5
PARL PARL Q9H300 Presenilins-associated rhomboid-like protein, mitochondrial chr3 GO:2000377 Not Cancer Driver No 49 0.129 28 5 0.179 0
PAX2_ENST00000428433 PAX2 Q02962 Paired box protein Pax-2 chr10 GO:2000377 Not Cancer Driver No 62 0.149 296 48 0.162 23
PDGFB PDGFB P01127 Platelet-derived growth factor subunit B chr22 GO:2000377 Census Yes 37 0.154 99 22 0.222 2
PDGFRB PDGFRB P09619 Platelet-derived growth factor receptor beta chr5 GO:2000377 Census, Compendium Yes 164 0.148 231 44 0.19 7
PDK3_ENST00000379162 PDK3 Q15120 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial chrX GO:2000377 Not Cancer Driver No 61 0.15 28 6 0.214 1
PID1 PID1 Q7Z2X4 PTB-containing, cubilin and LRP1-interacting protein chr2 GO:2000377 Not Cancer Driver No 70 0.28 24 10 0.417 0
PIKFYVE PIKFYVE Q9Y2I7 1-phosphatidylinositol 3-phosphate 5-kinase chr2 GO:2000377 Not Cancer Driver No 278 0.133 848 101 0.119 1
PINK1 PINK1 Q9BXM7 Serine/threonine-protein kinase PINK1, mitochondrial chr1 GO:2000377 Not Cancer Driver No 57 0.098 99 13 0.131 23
PLCG2 PLCG2 P16885 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 chr16 GO:2000377 Not Cancer Driver No 248 0.196 142 30 0.211 1
PLIN5 PLIN5 Q00G26 Perilipin-5 chr19 GO:2000377 Not Cancer Driver No 49 0.106 192 21 0.109 0
PON3 PON3 Q15166 Serum paraoxonase/lactonase 3 chr7 GO:2000377 Not Cancer Driver No 69 0.195 32 6 0.188 0
PPARA_ENST00000402126 PPARA Q07869 Peroxisome proliferator-activated receptor alpha chr22 GO:2000377 Not Cancer Driver No 63 0.135 68 9 0.132 0
PRCP_ENST00000313010 PRCP P42785 Lysosomal Pro-X carboxypeptidase chr11 GO:2000377 Not Cancer Driver No 58 0.117 0 0 0.0 0
PRDX2 PRDX2 P32119 Peroxiredoxin-2 chr19 GO:2000377 Not Cancer Driver No 24 0.121 30 4 0.133 0
PRKCD_ENST00000330452 PRKCD Q05655 Protein kinase C delta type chr3 GO:2000377 Compendium Yes 79 0.117 43 9 0.209 0
PRKN PRKN O60260 E3 ubiquitin-protein ligase parkin chr6 GO:2000377 Not Cancer Driver No 110 0.237 78 15 0.192 31
PTK2B_ENST00000346049 PTK2B Q14289 Protein-tyrosine kinase 2-beta chr8 GO:2000377 Not Cancer Driver No 161 0.16 261 37 0.142 0
RAB27A_ENST00000336787 RAB27A P51159 Ras-related protein Rab-27A chr15 GO:2000377 Not Cancer Driver No 25 0.113 15 4 0.267 3
RAC1_ENST00000348035 RAC1 P63000 Ras-related C3 botulinum toxin substrate 1 chr7 GO:2000377 Census, Compendium Yes 66 0.344 2 1 0.5 6
RAC2 RAC2 P15153 Ras-related C3 botulinum toxin substrate 2 chr22 GO:2000377 Not Cancer Driver No 31 0.161 0 0 0.0 2
RHOA RHOA P61586 Transforming protein RhoA chr3 GO:2000377 Census, Compendium Yes 99 0.513 46 13 0.283 2
RIPK1_ENST00000380409 RIPK1 Q13546 Receptor-interacting serine/threonine-protein kinase 1 chr6 GO:2000377 Compendium Yes 82 0.122 277 39 0.141 4
RIPK3 RIPK3 Q9Y572 Receptor-interacting serine/threonine-protein kinase 3 chr14 GO:2000377 Not Cancer Driver No 66 0.127 295 39 0.132 0
RNF41_ENST00000615206 RNF41 Q9H4P4 E3 ubiquitin-protein ligase NRDP1 chr12 GO:2000377 Not Cancer Driver No 44 0.139 33 2 0.061 0
ROMO1_ENST00000397416 ROMO1 P60602 Reactive oxygen species modulator 1 chr20 GO:2000377 Not Cancer Driver No 9 0.114 0 0 0.0 0
SIRT2 SIRT2 Q8IXJ6 NAD-dependent protein deacetylase sirtuin-2 chr19 GO:2000377 Not Cancer Driver No 56 0.144 85 17 0.2 0
SIRT5 SIRT5 Q9NXA8 NAD-dependent protein deacylase sirtuin-5, mitochondrial chr6 GO:2000377 Not Cancer Driver No 41 0.132 55 7 0.127 0
SLC18A2_ENST00000644641 SLC18A2 Q05940 Synaptic vesicular amine transporter chr10 GO:2000377 Not Cancer Driver No 105 0.204 23 7 0.304 1
SLC25A33 SLC25A33 Q9BSK2 Solute carrier family 25 member 33 chr1 GO:2000377 Not Cancer Driver No 23 0.072 4 0 0.0 0
SLC30A10 SLC30A10 Q6XR72 Zinc transporter 10 chr1 GO:2000377 Not Cancer Driver No 68 0.14 61 10 0.164 2
SLC5A3 SLC5A3 P53794 Sodium/myo-inositol cotransporter chr21 GO:2000377 Not Cancer Driver No 81 0.113 73 6 0.082 0
SNCA_ENST00000506244 SNCA P37840 Alpha-synuclein chr4 GO:2000377 Not Cancer Driver No 21 0.15 107 13 0.121 5
SOD1 SOD1 P00441 Superoxide dismutase [Cu-Zn] chr21 GO:2000377 Not Cancer Driver No 16 0.104 93 9 0.097 79
SOD2_ENST00000367055 SOD2 P04179 Superoxide dismutase [Mn], mitochondrial chr6 GO:2000377 Not Cancer Driver No 32 0.144 25 5 0.2 0
SPHK2 SPHK2 Q9NRA0 Sphingosine kinase 2 chr19 GO:2000377 Not Cancer Driver No 82 0.125 293 39 0.133 0
STK17A STK17A Q9UEE5 Serine/threonine-protein kinase 17A chr7 GO:2000377 Not Cancer Driver No 44 0.106 115 16 0.139 0
SYK_ENST00000375746 SYK P43405 Tyrosine-protein kinase SYK chr9 GO:2000377 Census Yes 96 0.151 131 27 0.206 5
TFAP2A TFAP2A P05549 Transcription factor AP-2-alpha chr6 GO:2000377 Not Cancer Driver No 77 0.176 275 44 0.16 4
TGFB1 TGFB1 P01137 Transforming growth factor beta-1 proprotein chr19 GO:2000377 Not Cancer Driver No 41 0.105 41 4 0.098 10
TGFBR2_ENST00000295754 TGFBR2 P37173 TGF-beta receptor type-2 chr3 GO:2000377 Census, Compendium Yes 106 0.187 60 16 0.267 25
THBS1 THBS1 P07996 Thrombospondin-1 chr15 GO:2000377 Not Cancer Driver No 188 0.161 320 58 0.181 0
TIGAR TIGAR Q9NQ88 Fructose-2,6-bisphosphatase TIGAR chr12 GO:2000377 Not Cancer Driver No 44 0.163 39 9 0.231 0
TLR4_ENST00000355622 TLR4 O00206 Toll-like receptor 4 chr9 GO:2000377 Not Cancer Driver No 292 0.348 0 0 0.0 0
TLR6 TLR6 Q9Y2C9 Toll-like receptor 6 chr4 GO:2000377 Not Cancer Driver No 99 0.124 1 0 0.0 0
TNF TNF P01375 Tumor necrosis factor chr6 GO:2000377 Not Cancer Driver No 24 0.103 45 3 0.067 0
TP53_ENST00000445888 TP53 P04637 Cellular tumor antigen p53 chr17 GO:2000377 Census, Compendium Yes 2891 7.356 282 1466 5.199 83
TRAP1 TRAP1 Q12931 Heat shock protein 75 kDa, mitochondrial chr16 GO:2000377 Not Cancer Driver No 74 0.105 110 11 0.1 0
TSPO_ENST00000329563 TSPO P30536 Translocator protein chr22 GO:2000377 Not Cancer Driver No 5 0.03 1 0 0.0 0
TUSC2 TUSC2 O75896 Tumor suppressor candidate 2 chr3 GO:2000377 Not Cancer Driver No 10 0.091 31 3 0.097 0
TYROBP TYROBP O43914 TYRO protein tyrosine kinase-binding protein chr19 GO:2000377 Not Cancer Driver No 24 0.212 28 8 0.286 0
UCP1 UCP1 P25874 Mitochondrial brown fat uncoupling protein 1 chr4 GO:2000377 Not Cancer Driver No 43 0.14 1 0 0.0 0
XDH XDH P47989 Xanthine dehydrogenase/oxidase chr2 GO:2000377 Not Cancer Driver No 279 0.209 134 24 0.179 1
ZC3H12A ZC3H12A Q5D1E8 Endoribonuclease ZC3H12A chr1 GO:2000377 Not Cancer Driver No 90 0.15 396 44 0.111 0
ZNF205_ENST00000382192 ZNF205 O95201 Zinc finger protein 205 chr16 GO:2000377 Not Cancer Driver No 74 0.134 367 49 0.134 0