Total number of protein in "GO:2000134" GO term: 69
| Identifier | UniProt Gene | UniProt Accession | UniProt Name | Chromosome | GO term | Database | Cancer Driver | Number of missense mutations | Missense mutation per residues | Number of disordered residues | Number of mutations in disordered regions | Disordered missense mutations per residues | Number of OMIM mutation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ACVR1_ENST00000434821 | ACVR1 | Q04771 | Activin receptor type-1 | chr2 | GO:2000134 | Census, Compendium | Yes | 78 | 0.153 | 21 | 8 | 0.381 | 8 |
| APC | APC | P25054 | Adenomatous polyposis coli protein | chr5 | GO:2000134 | Census, Compendium | Yes | 412 | 0.145 | 2406 | 345 | 0.143 | 22 |
| ATM_ENST00000452508 | ATM | Q13315 | Serine-protein kinase ATM | chr11 | GO:2000134 | Census, Compendium | Yes | 469 | 0.153 | 225 | 39 | 0.173 | 41 |
| BCL2_ENST00000333681 | BCL2 | P10415 | Apoptosis regulator Bcl-2 | chr18 | GO:2000134 | Census, Compendium | Yes | 24 | 0.1 | 72 | 5 | 0.069 | 0 |
| BRD7_ENST00000394688 | BRD7 | Q9NPI1 | Bromodomain-containing protein 7 | chr16 | GO:2000134 | Compendium | Yes | 82 | 0.126 | 482 | 57 | 0.118 | 0 |
| BTN2A2 | BTN2A2 | Q8WVV5 | Butyrophilin subfamily 2 member A2 | chr6 | GO:2000134 | Not Cancer Driver | No | 92 | 0.176 | 24 | 2 | 0.083 | 0 |
| CASP2 | CASP2 | P42575 | Caspase-2 | chr7 | GO:2000134 | Not Cancer Driver | No | 63 | 0.139 | 42 | 12 | 0.286 | 0 |
| CCL2 | CCL2 | P13500 | C-C motif chemokine 2 | chr17 | GO:2000134 | Not Cancer Driver | No | 20 | 0.202 | 15 | 5 | 0.333 | 0 |
| CCND1 | CCND1 | P24385 | G1/S-specific cyclin-D1 | chr11 | GO:2000134 | Census, Compendium | Yes | 55 | 0.186 | 31 | 25 | 0.806 | 0 |
| CDC73 | CDC73 | Q6P1J9 | Parafibromin | chr1 | GO:2000134 | Census, Compendium | Yes | 110 | 0.207 | 210 | 39 | 0.186 | 2 |
| CDK2 | CDK2 | P24941 | Cyclin-dependent kinase 2 | chr12 | GO:2000134 | Not Cancer Driver | No | 24 | 0.081 | 0 | 0 | 0.0 | 0 |
| CDK2AP2 | CDK2AP2 | O75956 | Cyclin-dependent kinase 2-associated protein 2 | chr11 | GO:2000134 | Not Cancer Driver | No | 10 | 0.079 | 126 | 10 | 0.079 | 0 |
| CDKN1A_ENST00000373711 | CDKN1A | P38936 | Cyclin-dependent kinase inhibitor 1 | chr6 | GO:2000134 | Census, Compendium | Yes | 48 | 0.293 | 121 | 30 | 0.248 | 0 |
| CDKN1B | CDKN1B | P46527 | Cyclin-dependent kinase inhibitor 1B | chr12 | GO:2000134 | Census, Compendium | Yes | 19 | 0.096 | 198 | 19 | 0.096 | 0 |
| CDKN2B | CDKN2B | P42772 | Cyclin-dependent kinase 4 inhibitor B | chr9 | GO:2000134 | Not Cancer Driver | No | 15 | 0.109 | 67 | 3 | 0.045 | 0 |
| CHEK2_ENST00000405598 | CHEK2 | O96017 | Serine/threonine-protein kinase Chk2 | chr22 | GO:2000134 | Census, Compendium | Yes | 335 | 0.617 | 157 | 130 | 0.828 | 13 |
| CRADD_ENST00000332896 | CRADD | P78560 | Death domain-containing protein CRADD | chr12 | GO:2000134 | Not Cancer Driver | No | 35 | 0.176 | 45 | 5 | 0.111 | 1 |
| CRLF3 | CRLF3 | Q8IUI8 | Cytokine receptor-like factor 3 | chr17 | GO:2000134 | Not Cancer Driver | No | 46 | 0.104 | 79 | 6 | 0.076 | 0 |
| CTDSP1 | CTDSP1 | Q9GZU7 | Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 | chr2 | GO:2000134 | Not Cancer Driver | No | 34 | 0.13 | 46 | 2 | 0.043 | 0 |
| CTDSP2 | CTDSP2 | O14595 | Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 | chr12 | GO:2000134 | Not Cancer Driver | No | 35 | 0.129 | 18 | 0 | 0.0 | 0 |
| CTDSPL | CTDSPL | O15194 | CTD small phosphatase-like protein | chr3 | GO:2000134 | Not Cancer Driver | No | 32 | 0.116 | 60 | 4 | 0.067 | 0 |
| DACT1 | DACT1 | Q9NYF0 | Dapper homolog 1 | chr14 | GO:2000134 | Not Cancer Driver | No | 163 | 0.195 | 598 | 127 | 0.212 | 1 |
| DCUN1D3 | DCUN1D3 | Q8IWE4 | DCN1-like protein 3 | chr16 | GO:2000134 | Not Cancer Driver | No | 36 | 0.118 | 118 | 9 | 0.076 | 0 |
| DLG1_ENST00000419354 | DLG1 | Q12959 | Disks large homolog 1 | chr3 | GO:2000134 | Not Cancer Driver | No | 120 | 0.133 | 460 | 67 | 0.146 | 0 |
| E2F7 | E2F7 | Q96AV8 | Transcription factor E2F7 | chr12 | GO:2000134 | Not Cancer Driver | No | 122 | 0.134 | 554 | 70 | 0.126 | 0 |
| EZH2_ENST00000460911 | EZH2 | Q15910 | Histone-lysine N-methyltransferase EZH2 | chr7 | GO:2000134 | Census, Compendium | Yes | 120 | 0.161 | 284 | 44 | 0.155 | 11 |
| FAM107A_ENST00000394481 | FAM107A | O95990 | Actin-associated protein FAM107A | chr3 | GO:2000134 | Not Cancer Driver | No | 25 | 0.174 | 141 | 24 | 0.17 | 0 |
| FBXO31 | FBXO31 | Q5XUX0 | F-box only protein 31 | chr16 | GO:2000134 | Not Cancer Driver | No | 72 | 0.134 | 231 | 30 | 0.13 | 0 |
| FBXO7 | FBXO7 | Q9Y3I1 | F-box only protein 7 | chr22 | GO:2000134 | Not Cancer Driver | No | 75 | 0.144 | 243 | 38 | 0.156 | 1 |
| FHL1_ENST00000345434 | FHL1 | Q13642 | Four and a half LIM domains protein 1 | chrX | GO:2000134 | Not Cancer Driver | No | 56 | 0.173 | 51 | 7 | 0.137 | 13 |
| GFI1B | GFI1B | Q5VTD9 | Zinc finger protein Gfi-1b | chr9 | GO:2000134 | Not Cancer Driver | No | 50 | 0.152 | 142 | 23 | 0.162 | 0 |
| GIGYF2_ENST00000409547 | GIGYF2 | Q6Y7W6 | GRB10-interacting GYF protein 2 | chr2 | GO:2000134 | Not Cancer Driver | No | 176 | 0.135 | 1096 | 158 | 0.144 | 6 |
| GJC2 | GJC2 | Q5T442 | Gap junction gamma-2 protein | chr1 | GO:2000134 | Not Cancer Driver | No | 33 | 0.075 | 225 | 10 | 0.044 | 6 |
| GML | GML | Q99445 | Glycosyl-phosphatidylinositol-anchored molecule-like protein | chr8 | GO:2000134 | Not Cancer Driver | No | 49 | 0.31 | 12 | 6 | 0.5 | 0 |
| GPNMB | GPNMB | Q14956 | Transmembrane glycoprotein NMB | chr7 | GO:2000134 | Not Cancer Driver | No | 89 | 0.156 | 94 | 18 | 0.191 | 0 |
| GTSE1 | GTSE1 | Q9NYZ3 | G2 and S phase-expressed protein 1 | chr22 | GO:2000134 | Not Cancer Driver | No | 91 | 0.126 | 660 | 85 | 0.129 | 0 |
| INHBA_ENST00000442711 | INHBA | P08476 | Inhibin beta A chain | chr7 | GO:2000134 | Not Cancer Driver | No | 148 | 0.347 | 154 | 63 | 0.409 | 0 |
| JADE1_ENST00000512960 | JADE1 | Q6IE81 | Protein Jade-1 | chr4 | GO:2000134 | Not Cancer Driver | No | 94 | 0.112 | 409 | 47 | 0.115 | 0 |
| KANK2_ENST00000586659 | KANK2 | Q63ZY3 | KN motif and ankyrin repeat domain-containing protein 2 | chr19 | GO:2000134 | Not Cancer Driver | No | 107 | 0.126 | 531 | 71 | 0.134 | 3 |
| MDM2_ENST00000539479 | MDM2 | Q00987 | E3 ubiquitin-protein ligase Mdm2 | chr12 | GO:2000134 | Census, Compendium | Yes | 56 | 0.114 | 297 | 37 | 0.125 | 0 |
| MUC1_ENST00000611571 | MUC1 | P15941 | Mucin-1 | chr1 | GO:2000134 | Census | Yes | 40 | 0.032 | 1050 | 19 | 0.018 | 0 |
| MYO16_ENST00000357550 | MYO16 | Q9Y6X6 | Unconventional myosin-XVI | chr13 | GO:2000134 | Not Cancer Driver | No | 412 | 0.222 | 681 | 112 | 0.164 | 0 |
| NACC2_ENST00000371753 | NACC2 | Q96BF6 | Nucleus accumbens-associated protein 2 | chr9 | GO:2000134 | Not Cancer Driver | No | 24 | 0.041 | 238 | 10 | 0.042 | 0 |
| PIDD1 | PIDD1 | Q9HB75 | p53-induced death domain-containing protein 1 | chr11 | GO:2000134 | Not Cancer Driver | No | 93 | 0.102 | 137 | 14 | 0.102 | 0 |
| PKD2 | PKD2 | Q13563 | Polycystin-2 | chr4 | GO:2000134 | Not Cancer Driver | No | 113 | 0.117 | 375 | 35 | 0.093 | 10 |
| PLK2 | PLK2 | Q9NYY3 | Serine/threonine-protein kinase PLK2 | chr5 | GO:2000134 | Not Cancer Driver | No | 92 | 0.134 | 178 | 21 | 0.118 | 0 |
| PLK3 | PLK3 | Q9H4B4 | Serine/threonine-protein kinase PLK3 | chr1 | GO:2000134 | Not Cancer Driver | No | 75 | 0.116 | 202 | 15 | 0.074 | 0 |
| PLK5 | PLK5 | Q496M5 | Inactive serine/threonine-protein kinase PLK5 | chr19 | GO:2000134 | Not Cancer Driver | No | 8 | 0.024 | 215 | 4 | 0.019 | 0 |
| PML | PML | P29590 | Protein PML | chr15 | GO:2000134 | Census, Compendium | Yes | 112 | 0.127 | 312 | 34 | 0.109 | 0 |
| PRAP1 | PRAP1 | Q96NZ9 | Proline-rich acidic protein 1 | chr10 | GO:2000134 | Not Cancer Driver | No | 14 | 0.093 | 124 | 13 | 0.105 | 0 |
| PRKDC | PRKDC | P78527 | DNA-dependent protein kinase catalytic subunit | chr8 | GO:2000134 | Not Cancer Driver | No | 538 | 0.13 | 421 | 61 | 0.145 | 2 |
| PRMT2_ENST00000355680 | PRMT2 | P55345 | Protein arginine N-methyltransferase 2 | chr21 | GO:2000134 | Not Cancer Driver | No | 48 | 0.111 | 70 | 8 | 0.114 | 0 |
| PTEN | PTEN | P60484 | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN | chr10 | GO:2000134 | Census, Compendium | Yes | 505 | 1.253 | 76 | 4 | 0.053 | 41 |
| RB1 | RB1 | P06400 | Retinoblastoma-associated protein | chr13 | GO:2000134 | Census, Compendium | Yes | 140 | 0.151 | 282 | 32 | 0.113 | 22 |
| RBL1 | RBL1 | P28749 | Retinoblastoma-like protein 1 | chr20 | GO:2000134 | Not Cancer Driver | No | 140 | 0.131 | 335 | 41 | 0.122 | 0 |
| RBL2 | RBL2 | Q08999 | Retinoblastoma-like protein 2 | chr16 | GO:2000134 | Not Cancer Driver | No | 116 | 0.102 | 504 | 56 | 0.111 | 0 |
| RFWD3 | RFWD3 | Q6PCD5 | E3 ubiquitin-protein ligase RFWD3 | chr16 | GO:2000134 | Census | Yes | 68 | 0.088 | 318 | 30 | 0.094 | 1 |
| RPA2_ENST00000373912 | RPA2 | P15927 | Replication protein A 32 kDa subunit | chr1 | GO:2000134 | Not Cancer Driver | No | 28 | 0.104 | 114 | 16 | 0.14 | 0 |
| RPL26 | RPL26 | P61254 | 60S ribosomal protein L26 | chr17 | GO:2000134 | Not Cancer Driver | No | 16 | 0.11 | 114 | 13 | 0.114 | 0 |
| RPS27L | RPS27L | Q71UM5 | 40S ribosomal protein S27-like | chr15 | GO:2000134 | Not Cancer Driver | No | 4 | 0.048 | 22 | 2 | 0.091 | 0 |
| SDE2 | SDE2 | Q6IQ49 | Replication stress response regulator SDE2 | chr1 | GO:2000134 | Not Cancer Driver | No | 56 | 0.124 | 290 | 35 | 0.121 | 0 |
| SLFN11_ENST00000308377 | SLFN11 | Q7Z7L1 | Schlafen family member 11 | chr17 | GO:2000134 | Not Cancer Driver | No | 177 | 0.196 | 34 | 8 | 0.235 | 0 |
| TFDP3 | TFDP3 | Q5H9I0 | Transcription factor Dp family member 3 | chrX | GO:2000134 | Not Cancer Driver | No | 84 | 0.207 | 186 | 42 | 0.226 | 0 |
| TP53_ENST00000445888 | TP53 | P04637 | Cellular tumor antigen p53 | chr17 | GO:2000134 | Census, Compendium | Yes | 2891 | 7.356 | 282 | 1466 | 5.199 | 83 |
| TREX1_ENST00000625293 | TREX1 | Q9NSU2 | Three-prime repair exonuclease 1 | chr3 | GO:2000134 | Not Cancer Driver | No | 26 | 0.083 | 98 | 10 | 0.102 | 18 |
| TRIAP1 | TRIAP1 | O43715 | TP53-regulated inhibitor of apoptosis 1 | chr12 | GO:2000134 | Not Cancer Driver | No | 9 | 0.118 | 20 | 1 | 0.05 | 0 |
| WAC | WAC | Q9BTA9 | WW domain-containing adapter protein with coiled-coil | chr10 | GO:2000134 | Not Cancer Driver | No | 106 | 0.164 | 571 | 95 | 0.166 | 0 |
| WEE1 | WEE1 | P30291 | Wee1-like protein kinase | chr11 | GO:2000134 | Not Cancer Driver | No | 60 | 0.093 | 399 | 27 | 0.068 | 0 |
| ZNF655_ENST00000252713 | ZNF655 | Q8N720 | Zinc finger protein 655 | chr7 | GO:2000134 | Not Cancer Driver | No | 62 | 0.126 | 202 | 27 | 0.134 | 0 |