Total number of protein in "GO:2000116" GO term: 59
| Identifier | UniProt Gene | UniProt Accession | UniProt Name | Chromosome | GO term | Database | Cancer Driver | Number of missense mutations | Missense mutation per residues | Number of disordered residues | Number of mutations in disordered regions | Disordered missense mutations per residues | Number of OMIM mutation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| APAF1 | APAF1 | O14727 | Apoptotic protease-activating factor 1 | chr12 | GO:2000116 | Not Cancer Driver | No | 127 | 0.102 | 17 | 1 | 0.059 | 0 |
| ASPH | ASPH | Q12797 | Aspartyl/asparaginyl beta-hydroxylase | chr8 | GO:2000116 | Not Cancer Driver | No | 109 | 0.144 | 373 | 53 | 0.142 | 1 |
| BAD_ENST00000309032 | BAD | Q92934 | Bcl2-associated agonist of cell death | chr11 | GO:2000116 | Not Cancer Driver | No | 14 | 0.083 | 163 | 14 | 0.086 | 0 |
| BAK1 | BAK1 | Q16611 | Bcl-2 homologous antagonist/killer | chr6 | GO:2000116 | Not Cancer Driver | No | 38 | 0.18 | 58 | 9 | 0.155 | 0 |
| BAX_ENST00000345358 | BAX | Q07812 | Apoptosis regulator BAX | chr19 | GO:2000116 | Census | Yes | 30 | 0.156 | 39 | 2 | 0.051 | 0 |
| BCL2L12 | BCL2L12 | Q9HB09 | Bcl-2-like protein 12 | chr19 | GO:2000116 | Census, Compendium | Yes | 40 | 0.12 | 132 | 10 | 0.076 | 0 |
| BIRC2 | BIRC2 | Q13490 | Baculoviral IAP repeat-containing protein 2 | chr11 | GO:2000116 | Not Cancer Driver | No | 69 | 0.112 | 83 | 9 | 0.108 | 0 |
| BIRC3_ENST00000532808 | BIRC3 | Q13489 | Baculoviral IAP repeat-containing protein 3 | chr11 | GO:2000116 | Census, Compendium | Yes | 77 | 0.127 | 98 | 16 | 0.163 | 0 |
| BOK | BOK | Q9UMX3 | Bcl-2-related ovarian killer protein | chr2 | GO:2000116 | Not Cancer Driver | No | 7 | 0.033 | 0 | 0 | 0.0 | 0 |
| CAAP1 | CAAP1 | Q9H8G2 | Caspase activity and apoptosis inhibitor 1 | chr9 | GO:2000116 | Not Cancer Driver | No | 28 | 0.078 | 234 | 18 | 0.077 | 0 |
| CARD16 | CARD16 | Q5EG05 | Caspase recruitment domain-containing protein 16 | chr11 | GO:2000116 | Not Cancer Driver | No | 36 | 0.183 | 23 | 7 | 0.304 | 0 |
| CARD18 | CARD18 | P57730 | Caspase recruitment domain-containing protein 18 | chr11 | GO:2000116 | Not Cancer Driver | No | 24 | 0.267 | 14 | 1 | 0.071 | 0 |
| CARD8_ENST00000519940 | CARD8 | Q9Y2G2 | Caspase recruitment domain-containing protein 8 | chr19 | GO:2000116 | Not Cancer Driver | No | 53 | 0.099 | 126 | 7 | 0.056 | 1 |
| CASP8_ENST00000432109 | CASP8 | Q14790 | Caspase-8 | chr2 | GO:2000116 | Census, Compendium | Yes | 142 | 0.296 | 106 | 12 | 0.113 | 1 |
| CASP9 | CASP9 | P55211 | Caspase-9 | chr1 | GO:2000116 | Census | Yes | 49 | 0.118 | 71 | 7 | 0.099 | 0 |
| CAST_ENST00000395813 | CAST | P20810 | Calpastatin | chr5 | GO:2000116 | Not Cancer Driver | No | 73 | 0.103 | 708 | 73 | 0.103 | 0 |
| CIDEB | CIDEB | Q9UHD4 | Cell death activator CIDE-B | chr14 | GO:2000116 | Not Cancer Driver | No | 19 | 0.087 | 23 | 1 | 0.043 | 0 |
| CSN2 | CSN2 | P05814 | Beta-casein | chr4 | GO:2000116 | Not Cancer Driver | No | 49 | 0.217 | 41 | 12 | 0.293 | 0 |
| CST7 | CST7 | O76096 | Cystatin-F | chr20 | GO:2000116 | Not Cancer Driver | No | 12 | 0.083 | 15 | 2 | 0.133 | 0 |
| CYCS_ENST00000409409 | CYCS | P99999 | Cytochrome c | chr7 | GO:2000116 | Not Cancer Driver | No | 12 | 0.114 | 19 | 3 | 0.158 | 1 |
| CYFIP2 | CYFIP2 | Q96F07 | Cytoplasmic FMR1-interacting protein 2 | chr5 | GO:2000116 | Not Cancer Driver | No | 211 | 0.165 | 86 | 11 | 0.128 | 3 |
| DIABLO | DIABLO | Q9NR28 | Diablo IAP-binding mitochondrial protein | chr12 | GO:2000116 | Not Cancer Driver | No | 62 | 0.259 | 54 | 8 | 0.148 | 1 |
| FADD | FADD | Q13158 | FAS-associated death domain protein | chr11 | GO:2000116 | Not Cancer Driver | No | 26 | 0.125 | 45 | 10 | 0.222 | 1 |
| FAS | FAS | P25445 | Tumor necrosis factor receptor superfamily member 6 | chr10 | GO:2000116 | Census, Compendium | Yes | 55 | 0.164 | 62 | 18 | 0.29 | 22 |
| GRIN2A_ENST00000330684 | GRIN2A | Q12879 | Glutamate receptor ionotropic, NMDA 2A | chr16 | GO:2000116 | Census, Compendium | Yes | 528 | 0.361 | 506 | 207 | 0.409 | 31 |
| GSN | GSN | P06396 | Gelsolin | chr9 | GO:2000116 | Not Cancer Driver | No | 76 | 0.097 | 316 | 28 | 0.089 | 2 |
| HTRA2 | HTRA2 | O43464 | Serine protease HTRA2, mitochondrial | chr2 | GO:2000116 | Compendium | Yes | 44 | 0.096 | 127 | 9 | 0.071 | 2 |
| IFI16_ENST00000295809 | IFI16 | Q16666 | Gamma-interferon-inducible protein 16 | chr1 | GO:2000116 | Not Cancer Driver | No | 155 | 0.197 | 419 | 90 | 0.215 | 0 |
| IL9 | IL9 | P15248 | Interleukin-9 | chr5 | GO:2000116 | Not Cancer Driver | No | 12 | 0.083 | 4 | 0 | 0.0 | 0 |
| JAK2 | JAK2 | O60674 | Tyrosine-protein kinase JAK2 | chr9 | GO:2000116 | Census, Compendium | Yes | 136 | 0.12 | 59 | 5 | 0.085 | 5 |
| LGALS9 | LGALS9 | O00182 | Galectin-9 | chr17 | GO:2000116 | Not Cancer Driver | No | 54 | 0.152 | 65 | 16 | 0.246 | 0 |
| LGMN_ENST00000334869 | LGMN | Q99538 | Legumain | chr14 | GO:2000116 | Not Cancer Driver | No | 57 | 0.132 | 112 | 19 | 0.17 | 0 |
| LTF | LTF | P02788 | Lactotransferrin | chr3 | GO:2000116 | Not Cancer Driver | No | 131 | 0.185 | 21 | 4 | 0.19 | 0 |
| MMP9 | MMP9 | P14780 | Matrix metalloproteinase-9 | chr20 | GO:2000116 | Not Cancer Driver | No | 129 | 0.182 | 124 | 26 | 0.21 | 0 |
| MT3 | MT3 | P25713 | Metallothionein-3 | chr16 | GO:2000116 | Not Cancer Driver | No | 7 | 0.103 | 0 | 0 | 0.0 | 0 |
| NLE1 | NLE1 | Q9NVX2 | Notchless protein homolog 1 | chr17 | GO:2000116 | Not Cancer Driver | No | 60 | 0.124 | 21 | 3 | 0.143 | 0 |
| NLRC4_ENST00000360906 | NLRC4 | Q9NPP4 | NLR family CARD domain-containing protein 4 | chr2 | GO:2000116 | Not Cancer Driver | No | 205 | 0.2 | 15 | 2 | 0.133 | 3 |
| NLRP6 | NLRP6 | P59044 | NACHT, LRR and PYD domains-containing protein 6 | chr11 | GO:2000116 | Not Cancer Driver | No | 106 | 0.119 | 203 | 28 | 0.138 | 0 |
| NOL3_ENST00000268605 | NOL3 | O60936 | Nucleolar protein 3 | chr16 | GO:2000116 | Not Cancer Driver | No | 20 | 0.096 | 179 | 17 | 0.095 | 2 |
| PAK2 | PAK2 | Q13177 | Serine/threonine-protein kinase PAK 2 | chr3 | GO:2000116 | Compendium | Yes | 89 | 0.17 | 242 | 49 | 0.202 | 0 |
| PARK7_ENST00000377488 | PARK7 | Q99497 | Parkinson disease protein 7 | chr1 | GO:2000116 | Not Cancer Driver | No | 11 | 0.058 | 30 | 0 | 0.0 | 5 |
| PCID2_ENST00000375479 | PCID2 | Q5JVF3 | PCI domain-containing protein 2 | chr13 | GO:2000116 | Not Cancer Driver | No | 46 | 0.115 | 13 | 5 | 0.385 | 0 |
| PERP | PERP | Q96FX8 | p53 apoptosis effector related to PMP-22 | chr6 | GO:2000116 | Not Cancer Driver | No | 28 | 0.145 | 0 | 0 | 0.0 | 1 |
| PIH1D1 | PIH1D1 | Q9NWS0 | PIH1 domain-containing protein 1 | chr19 | GO:2000116 | Not Cancer Driver | No | 30 | 0.103 | 157 | 13 | 0.083 | 0 |
| PLAUR | PLAUR | Q03405 | Urokinase plasminogen activator surface receptor | chr19 | GO:2000116 | Not Cancer Driver | No | 49 | 0.146 | 18 | 5 | 0.278 | 0 |
| PRR7_ENST00000502922 | PRR7 | Q8TB68 | Proline-rich protein 7 | chr5 | GO:2000116 | Not Cancer Driver | No | 10 | 0.036 | 199 | 6 | 0.03 | 0 |
| PSMB9 | PSMB9 | P28065 | Proteasome subunit beta type-9 | chr6 | GO:2000116 | Not Cancer Driver | No | 21 | 0.096 | 17 | 1 | 0.059 | 1 |
| PYCARD | PYCARD | Q9ULZ3 | Apoptosis-associated speck-like protein containing a CARD | chr16 | GO:2000116 | Not Cancer Driver | No | 16 | 0.082 | 39 | 4 | 0.103 | 0 |
| RFFL_ENST00000394597 | RFFL | Q8WZ73 | E3 ubiquitin-protein ligase rififylin | chr17 | GO:2000116 | Not Cancer Driver | No | 50 | 0.138 | 150 | 21 | 0.14 | 0 |
| RFPL1 | RFPL1 | O75677 | Ret finger protein-like 1 | chr22 | GO:2000116 | Not Cancer Driver | No | 73 | 0.23 | 28 | 5 | 0.179 | 0 |
| RIPK2 | RIPK2 | O43353 | Receptor-interacting serine/threonine-protein kinase 2 | chr8 | GO:2000116 | Not Cancer Driver | No | 63 | 0.117 | 143 | 20 | 0.14 | 0 |
| RNF34_ENST00000361234 | RNF34 | Q969K3 | E3 ubiquitin-protein ligase RNF34 | chr12 | GO:2000116 | Not Cancer Driver | No | 30 | 0.081 | 112 | 7 | 0.062 | 0 |
| RPS3_ENST00000527446 | RPS3 | P23396 | 40S ribosomal protein S3 | chr11 | GO:2000116 | Not Cancer Driver | No | 22 | 0.091 | 48 | 4 | 0.083 | 0 |
| SMAD3 | SMAD3 | P84022 | Mothers against decapentaplegic homolog 3 | chr15 | GO:2000116 | Census, Compendium | Yes | 97 | 0.228 | 111 | 19 | 0.171 | 5 |
| ST18 | ST18 | O60284 | Suppression of tumorigenicity 18 protein | chr8 | GO:2000116 | Not Cancer Driver | No | 330 | 0.315 | 820 | 282 | 0.344 | 0 |
| TBC1D10A_ENST00000215790 | TBC1D10A | Q9BXI6 | TBC1 domain family member 10A | chr22 | GO:2000116 | Not Cancer Driver | No | 72 | 0.142 | 209 | 26 | 0.124 | 0 |
| TFAP4 | TFAP4 | Q01664 | Transcription factor AP-4 | chr16 | GO:2000116 | Compendium | Yes | 61 | 0.18 | 285 | 52 | 0.182 | 0 |
| TNF | TNF | P01375 | Tumor necrosis factor | chr6 | GO:2000116 | Not Cancer Driver | No | 24 | 0.103 | 45 | 3 | 0.067 | 0 |
| XIAP_ENST00000434753 | XIAP | P98170 | E3 ubiquitin-protein ligase XIAP | chrX | GO:2000116 | Not Cancer Driver | No | 89 | 0.179 | 55 | 6 | 0.109 | 0 |