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Total number of protein in "GO:1901214" GO term:  256

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
AARS AARS1 P49588 Alanine--tRNA ligase, cytoplasmic chr16 GO:1901214 Not Cancer Driver No 97 0.1 140 14 0.1 5
ABL1_ENST00000318560 ABL1 P00519 Tyrosine-protein kinase ABL1 chr9 GO:1901214 Census, Compendium Yes 139 0.123 604 73 0.121 2
ADAM8 ADAM8 P78325 Disintegrin and metalloproteinase domain-containing protein 8 chr10 GO:1901214 Not Cancer Driver No 82 0.1 230 13 0.057 0
ADNP ADNP Q9H2P0 Activity-dependent neuroprotector homeobox protein chr20 GO:1901214 Not Cancer Driver No 130 0.118 615 66 0.107 0
ADORA1 ADORA1 P30542 Adenosine receptor A1 chr1 GO:1901214 Not Cancer Driver No 64 0.196 12 4 0.333 0
ADORA2A ADORA2A P29274 Adenosine receptor A2a chr22 GO:1901214 Not Cancer Driver No 61 0.148 93 11 0.118 0
AGAP2 AGAP2 Q99490 Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 chr12 GO:1901214 Not Cancer Driver No 133 0.112 754 81 0.107 0
AIFM1 AIFM1 O95831 Apoptosis-inducing factor 1, mitochondrial chrX GO:1901214 Not Cancer Driver No 88 0.144 166 22 0.133 11
AIMP2 AIMP2 Q13155 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 chr7 GO:1901214 Not Cancer Driver No 46 0.144 61 8 0.131 0
AKT1S1_ENST00000391834 AKT1S1 Q96B36 Proline-rich AKT1 substrate 1 chr19 GO:1901214 Not Cancer Driver No 23 0.09 256 23 0.09 0
ALKBH1 ALKBH1 Q13686 Nucleic acid dioxygenase ALKBH1 chr14 GO:1901214 Not Cancer Driver No 55 0.141 77 11 0.143 0
ANGPT1 ANGPT1 Q15389 Angiopoietin-1 chr8 GO:1901214 Not Cancer Driver No 130 0.261 131 24 0.183 1
APOE APOE P02649 Apolipoprotein E chr19 GO:1901214 Not Cancer Driver No 25 0.079 124 6 0.048 12
ARRB2_ENST00000269260 ARRB2 P32121 Beta-arrestin-2 chr17 GO:1901214 Not Cancer Driver No 46 0.112 122 22 0.18 0
ASCL1 ASCL1 P50553 Achaete-scute homolog 1 chr12 GO:1901214 Not Cancer Driver No 33 0.14 182 24 0.132 0
ATF2 ATF2 P15336 Cyclic AMP-dependent transcription factor ATF-2 chr2 GO:1901214 Not Cancer Driver No 65 0.129 451 58 0.129 0
ATF4_ENST00000404241 ATF4 P18848 Cyclic AMP-dependent transcription factor ATF-4 chr22 GO:1901214 Not Cancer Driver No 53 0.151 259 38 0.147 0
ATM_ENST00000452508 ATM Q13315 Serine-protein kinase ATM chr11 GO:1901214 Census, Compendium Yes 469 0.153 225 39 0.173 41
AXL AXL P30530 Tyrosine-protein kinase receptor UFO chr19 GO:1901214 Not Cancer Driver No 168 0.188 341 64 0.188 0
BACE1 BACE1 P56817 Beta-secretase 1 chr11 GO:1901214 Not Cancer Driver No 55 0.11 53 5 0.094 0
BAD_ENST00000309032 BAD Q92934 Bcl2-associated agonist of cell death chr11 GO:1901214 Not Cancer Driver No 14 0.083 163 14 0.086 0
BARHL1_ENST00000542090 BARHL1 Q9BZE3 BarH-like 1 homeobox protein chr9 GO:1901214 Not Cancer Driver No 43 0.131 240 30 0.125 0
BAX_ENST00000345358 BAX Q07812 Apoptosis regulator BAX chr19 GO:1901214 Census Yes 30 0.156 39 2 0.051 0
BCL2L1 BCL2L1 Q07817 Bcl-2-like protein 1 chr20 GO:1901214 Not Cancer Driver No 29 0.124 55 3 0.055 0
BCL2L11 BCL2L11 O43521 Bcl-2-like protein 11 chr2 GO:1901214 Not Cancer Driver No 42 0.212 130 17 0.131 0
BCL2_ENST00000333681 BCL2 P10415 Apoptosis regulator Bcl-2 chr18 GO:1901214 Census, Compendium Yes 24 0.1 72 5 0.069 0
BDNF_ENST00000439476 BDNF P23560 Brain-derived neurotrophic factor chr11 GO:1901214 Not Cancer Driver No 47 0.19 79 19 0.241 1
BHLHB9 BHLHB9 Q6PI77 Protein BHLHb9 chrX GO:1901214 Not Cancer Driver No 88 0.161 267 38 0.142 0
BOK BOK Q9UMX3 Bcl-2-related ovarian killer protein chr2 GO:1901214 Not Cancer Driver No 7 0.033 0 0 0.0 0
BTG2 BTG2 P78543 Protein BTG2 chr1 GO:1901214 Census Yes 32 0.203 7 2 0.286 0
C1QA C1QA P02745 Complement C1q subcomponent subunit A chr1 GO:1901214 Not Cancer Driver No 41 0.167 124 16 0.129 0
CAPN2 CAPN2 P17655 Calpain-2 catalytic subunit chr1 GO:1901214 Not Cancer Driver No 81 0.116 46 11 0.239 0
CASP2 CASP2 P42575 Caspase-2 chr7 GO:1901214 Not Cancer Driver No 63 0.139 42 12 0.286 0
CASP3 CASP3 P42574 Caspase-3 chr4 GO:1901214 Census Yes 32 0.116 62 5 0.081 0
CASP8_ENST00000432109 CASP8 Q14790 Caspase-8 chr2 GO:1901214 Census, Compendium Yes 142 0.296 106 12 0.113 1
CASP9 CASP9 P55211 Caspase-9 chr1 GO:1901214 Census Yes 49 0.118 71 7 0.099 0
CCL2 CCL2 P13500 C-C motif chemokine 2 chr17 GO:1901214 Not Cancer Driver No 20 0.202 15 5 0.333 0
CDC34 CDC34 P49427 Ubiquitin-conjugating enzyme E2 R1 chr19 GO:1901214 Not Cancer Driver No 26 0.11 95 11 0.116 0
CDC42_ENST00000344548 CDC42 P60953 Cell division control protein 42 homolog chr1 GO:1901214 Not Cancer Driver No 39 0.204 23 2 0.087 1
CDK5 CDK5 Q00535 Cyclin-dependent kinase 5 chr7 GO:1901214 Not Cancer Driver No 48 0.164 5 1 0.2 0
CDK5R1 CDK5R1 Q15078 Cyclin-dependent kinase 5 activator 1 chr17 GO:1901214 Not Cancer Driver No 35 0.114 103 16 0.155 0
CEBPB CEBPB P17676 CCAAT/enhancer-binding protein beta chr20 GO:1901214 Not Cancer Driver No 3 0.009 276 2 0.007 0
CHL1_ENST00000397491 CHL1 O00533 Neural cell adhesion molecule L1-like protein chr3 GO:1901214 Not Cancer Driver No 348 0.288 415 121 0.292 0
CHP1 CHP1 Q99653 Calcineurin B homologous protein 1 chr15 GO:1901214 Not Cancer Driver No 27 0.138 70 12 0.171 0
CHRNA7_ENST00000306901 CHRNA7 P36544 Neuronal acetylcholine receptor subunit alpha-7 chr15 GO:1901214 Not Cancer Driver No 71 0.141 18 4 0.222 0
CITED1_ENST00000246139 CITED1 Q99966 Cbp/p300-interacting transactivator 1 chrX GO:1901214 Not Cancer Driver No 24 0.124 166 21 0.127 0
CLCF1 CLCF1 Q9UBD9 Cardiotrophin-like cytokine factor 1 chr11 GO:1901214 Not Cancer Driver No 22 0.098 42 4 0.095 1
CLN3_ENST00000636147 CLN3 Q13286 Battenin chr16 GO:1901214 Not Cancer Driver No 58 0.132 69 10 0.145 9
CLU_ENST00000523500 CLU P10909 Clusterin chr8 GO:1901214 Not Cancer Driver No 69 0.154 156 27 0.173 0
CNTF CNTF P26441 Ciliary neurotrophic factor chr11 GO:1901214 Not Cancer Driver No 41 0.205 34 5 0.147 0
CNTFR_ENST00000351266 CNTFR P26992 Ciliary neurotrophic factor receptor subunit alpha chr9 GO:1901214 Not Cancer Driver No 50 0.134 92 8 0.087 0
CORO1A CORO1A P31146 Coronin-1A chr16 GO:1901214 Not Cancer Driver No 51 0.111 126 15 0.119 1
CPEB4 CPEB4 Q17RY0 Cytoplasmic polyadenylation element-binding protein 4 chr5 GO:1901214 Not Cancer Driver No 85 0.117 443 54 0.122 0
CRLF1 CRLF1 O75462 Cytokine receptor-like factor 1 chr19 GO:1901214 Not Cancer Driver No 51 0.121 101 7 0.069 14
CTNNB1_ENST00000643977 CTNNB1 P35222 Catenin beta-1 chr3 GO:1901214 Census, Compendium Yes 415 0.531 288 301 1.045 14
CTSZ CTSZ Q9UBR2 Cathepsin Z chr20 GO:1901214 Not Cancer Driver No 30 0.099 10 0 0.0 0
CX3CL1 CX3CL1 P78423 Fractalkine chr16 GO:1901214 Not Cancer Driver No 66 0.166 259 44 0.17 0
CX3CR1_ENST00000542107 CX3CR1 P49238 CX3C chemokine receptor 1 chr3 GO:1901214 Not Cancer Driver No 80 0.225 0 0 0.0 0
DAXX_ENST00000266000 DAXX Q9UER7 Death domain-associated protein 6 chr6 GO:1901214 Census, Compendium Yes 106 0.143 549 81 0.148 0
DCC DCC P43146 Netrin receptor DCC chr18 GO:1901214 Census, Compendium Yes 530 0.366 631 215 0.341 2
DDIT3_ENST00000623876 DDIT3 P35638 DNA damage-inducible transcript 3 protein chr12 GO:1901214 Census Yes 29 0.172 160 27 0.169 0
DDIT4 DDIT4 Q9NX09 DNA damage-inducible transcript 4 protein chr10 GO:1901214 Not Cancer Driver No 20 0.086 87 9 0.103 0
DHCR24 DHCR24 Q15392 Delta(24)-sterol reductase chr1 GO:1901214 Not Cancer Driver No 55 0.107 0 0 0.0 6
DKK1 DKK1 O94907 Dickkopf-related protein 1 chr10 GO:1901214 Not Cancer Driver No 58 0.218 47 8 0.17 0
DLX1 DLX1 P56177 Homeobox protein DLX-1 chr2 GO:1901214 Not Cancer Driver No 25 0.098 183 21 0.115 0
DNAJC5 DNAJC5 Q9H3Z4 DnaJ homolog subfamily C member 5 chr20 GO:1901214 Not Cancer Driver No 23 0.116 46 6 0.13 1
DRAXIN DRAXIN Q8NBI3 Draxin chr1 GO:1901214 Not Cancer Driver No 61 0.175 249 48 0.193 0
EFNB2_ENST00000245323 EFNB2 P52799 Ephrin-B2 chr13 GO:1901214 Not Cancer Driver No 42 0.126 97 15 0.155 0
EGLN2_ENST00000303961 EGLN2 Q96KS0 Prolyl hydroxylase EGLN2 chr19 GO:1901214 Not Cancer Driver No 52 0.128 201 17 0.085 0
EGLN3 EGLN3 Q9H6Z9 Prolyl hydroxylase EGLN3 chr14 GO:1901214 Not Cancer Driver No 33 0.138 13 0 0.0 0
EGR1 EGR1 P18146 Early growth response protein 1 chr5 GO:1901214 Not Cancer Driver No 78 0.144 501 72 0.144 0
EIF2S1 EIF2S1 P05198 Eukaryotic translation initiation factor 2 subunit 1 chr14 GO:1901214 Not Cancer Driver No 35 0.111 59 6 0.102 0
ELK1_ENST00000376983 ELK1 P19419 ETS domain-containing protein Elk-1 chrX GO:1901214 Not Cancer Driver No 51 0.119 327 34 0.104 0
EN1 EN1 Q05925 Homeobox protein engrailed-1 chr2 GO:1901214 Not Cancer Driver No 42 0.107 357 30 0.084 0
EN2 EN2 P19622 Homeobox protein engrailed-2 chr7 GO:1901214 Not Cancer Driver No 23 0.069 317 23 0.073 0
EPHA7 EPHA7 Q15375 Ephrin type-A receptor 7 chr6 GO:1901214 Census, Compendium Yes 280 0.281 71 15 0.211 0
EPHB1 EPHB1 P54762 Ephrin type-B receptor 1 chr3 GO:1901214 Not Cancer Driver No 316 0.321 67 17 0.254 0
ERBB3 ERBB3 P21860 Receptor tyrosine-protein kinase erbB-3 chr12 GO:1901214 Census, Compendium Yes 298 0.222 396 70 0.177 3
F2R F2R P25116 Proteinase-activated receptor 1 chr5 GO:1901214 Not Cancer Driver No 73 0.172 19 2 0.105 0
FAIM2 FAIM2 Q9BWQ8 Protein lifeguard 2 chr12 GO:1901214 Not Cancer Driver No 37 0.117 54 11 0.204 0
FASLG FASLG P48023 Tumor necrosis factor ligand superfamily member 6 chr1 GO:1901214 Not Cancer Driver No 65 0.231 94 18 0.191 1
FBXO7 FBXO7 Q9Y3I1 F-box only protein 7 chr22 GO:1901214 Not Cancer Driver No 75 0.144 243 38 0.156 1
FBXW7_ENST00000603841 FBXW7 Q969H0 F-box/WD repeat-containing protein 7 chr4 GO:1901214 Census, Compendium Yes 322 0.455 230 38 0.165 0
FCGR2B FCGR2B P31994 Low affinity immunoglobulin gamma Fc region receptor II-b chr1 GO:1901214 Census Yes 51 0.165 99 30 0.303 0
FGF20 FGF20 Q9NP95 Fibroblast growth factor 20 chr8 GO:1901214 Not Cancer Driver No 25 0.118 57 3 0.053 0
FGF8_ENST00000344255 FGF8 P55075 Fibroblast growth factor 8 chr10 GO:1901214 Not Cancer Driver No 30 0.129 79 9 0.114 6
FOS FOS P01100 Protein c-Fos chr14 GO:1901214 Not Cancer Driver No 45 0.118 245 33 0.135 0
FOXB1 FOXB1 Q99853 Forkhead box protein B1 chr15 GO:1901214 Not Cancer Driver No 31 0.095 114 5 0.044 0
FOXO3 FOXO3 O43524 Forkhead box protein O3 chr6 GO:1901214 Census, Compendium Yes 70 0.104 595 68 0.114 0
FOXQ1 FOXQ1 Q9C009 Forkhead box protein Q1 chr6 GO:1901214 Not Cancer Driver No 22 0.055 245 4 0.016 0
FYN FYN P06241 Tyrosine-protein kinase Fyn chr6 GO:1901214 Not Cancer Driver No 92 0.171 70 13 0.186 0
FZD1 FZD1 Q9UP38 Frizzled-1 chr7 GO:1901214 Not Cancer Driver No 78 0.121 133 2 0.015 0
FZD9 FZD9 O00144 Frizzled-9 chr7 GO:1901214 Not Cancer Driver No 55 0.093 61 0 0.0 0
G6PD_ENST00000621232 G6PD P11413 Glucose-6-phosphate 1-dehydrogenase chrX GO:1901214 Not Cancer Driver No 86 0.167 28 3 0.107 58
GABRA5_ENST00000355395 GABRA5 P31644 Gamma-aminobutyric acid receptor subunit alpha-5 chr15 GO:1901214 Not Cancer Driver No 146 0.316 55 14 0.255 3
GABRB2_ENST00000393959 GABRB2 P47870 Gamma-aminobutyric acid receptor subunit beta-2 chr5 GO:1901214 Not Cancer Driver No 165 0.322 27 10 0.37 1
GATA3_ENST00000346208 GATA3 P23771 Trans-acting T-cell-specific transcription factor GATA-3 chr10 GO:1901214 Census, Compendium Yes 111 0.251 364 87 0.239 2
GBA_ENST00000368373 GBA P04062 Lysosomal acid glucosylceramidase chr1 GO:1901214 Not Cancer Driver No 74 0.138 38 5 0.132 171
GBE1 GBE1 Q04446 1,4-alpha-glucan-branching enzyme chr3 GO:1901214 Not Cancer Driver No 101 0.144 8 0 0.0 9
GCLC GCLC P48506 Glutamate--cysteine ligase catalytic subunit chr6 GO:1901214 Not Cancer Driver No 73 0.115 167 18 0.108 3
GCLM GCLM P48507 Glutamate--cysteine ligase regulatory subunit chr1 GO:1901214 Not Cancer Driver No 32 0.117 31 3 0.097 0
GDF5_ENST00000374369 GDF5 P43026 Growth/differentiation factor 5 chr20 GO:1901214 Not Cancer Driver No 104 0.208 255 50 0.196 24
GDNF_ENST00000326524 GDNF P39905 Glial cell line-derived neurotrophic factor chr5 GO:1901214 Not Cancer Driver No 47 0.223 83 18 0.217 2
GFER GFER P55789 FAD-linked sulfhydryl oxidase ALR chr16 GO:1901214 Not Cancer Driver No 10 0.049 97 4 0.041 1
GFRAL GFRAL Q6UXV0 GDNF family receptor alpha-like chr6 GO:1901214 Not Cancer Driver No 176 0.447 5 2 0.4 0
GPI_ENST00000644934 GPI P06744 Glucose-6-phosphate isomerase chr19 GO:1901214 Not Cancer Driver No 77 0.138 73 11 0.151 24
GRID2 GRID2 O43424 Glutamate receptor ionotropic, delta-2 chr4 GO:1901214 Not Cancer Driver No 350 0.348 155 35 0.226 3
GRIK2 GRIK2 Q13002 Glutamate receptor ionotropic, kainate 2 chr6 GO:1901214 Not Cancer Driver No 284 0.313 57 19 0.333 0
GRIK5_ENST00000593562 GRIK5 Q16478 Glutamate receptor ionotropic, kainate 5 chr19 GO:1901214 Not Cancer Driver No 176 0.18 135 9 0.067 0
GRIN2B GRIN2B Q13224 Glutamate receptor ionotropic, NMDA 2B chr12 GO:1901214 Not Cancer Driver No 413 0.278 426 147 0.345 11
GRM4 GRM4 Q14833 Metabotropic glutamate receptor 4 chr6 GO:1901214 Not Cancer Driver No 187 0.205 74 22 0.297 0
GRN GRN P28799 Progranulin chr17 GO:1901214 Not Cancer Driver No 76 0.128 29 6 0.207 1
GSK3B_ENST00000264235 GSK3B P49841 Glycogen synthase kinase-3 beta chr3 GO:1901214 Not Cancer Driver No 56 0.133 146 13 0.089 0
HDGF_ENST00000357325 HDGF P51858 Hepatoma-derived growth factor chr1 GO:1901214 Not Cancer Driver No 35 0.146 203 29 0.143 0
HIF1A_ENST00000337138 HIF1A Q16665 Hypoxia-inducible factor 1-alpha chr14 GO:1901214 Census Yes 118 0.143 435 51 0.117 0
HIPK2 HIPK2 Q9H2X6 Homeodomain-interacting protein kinase 2 chr7 GO:1901214 Not Cancer Driver No 154 0.129 686 96 0.14 0
HMOX1 HMOX1 P09601 Heme oxygenase 1 chr22 GO:1901214 Not Cancer Driver No 46 0.16 81 13 0.16 0
HRAS HRAS P01112 GTPase HRas chr11 GO:1901214 Census, Compendium Yes 107 0.566 16 4 0.25 18
HSP90AB1 HSP90AB1 P08238 Heat shock protein HSP 90-beta chr6 GO:1901214 Census, Compendium Yes 100 0.138 254 43 0.169 0
HYOU1 HYOU1 Q9Y4L1 Hypoxia up-regulated protein 1 chr11 GO:1901214 Not Cancer Driver No 132 0.132 373 47 0.126 0
IFNG IFNG P01579 Interferon gamma chr12 GO:1901214 Not Cancer Driver No 51 0.307 23 6 0.261 0
IL10 IL10 P22301 Interleukin-10 chr1 GO:1901214 Not Cancer Driver No 19 0.107 23 1 0.043 0
IL27RA IL27RA Q6UWB1 Interleukin-27 receptor subunit alpha chr19 GO:1901214 Not Cancer Driver No 91 0.143 167 23 0.138 0
IL6ST_ENST00000336909 IL6ST P40189 Interleukin-6 receptor subunit beta chr5 GO:1901214 Census, Compendium Yes 102 0.111 315 40 0.127 2
ISL1 ISL1 P61371 Insulin gene enhancer protein ISL-1 chr5 GO:1901214 Not Cancer Driver No 85 0.244 180 41 0.228 0
ITGA1 ITGA1 P56199 Integrin alpha-1 chr5 GO:1901214 Not Cancer Driver No 156 0.132 107 13 0.121 0
ITGAM_ENST00000287497 ITGAM P11215 Integrin alpha-M chr16 GO:1901214 Not Cancer Driver No 191 0.166 133 12 0.09 0
ITGB2_ENST00000355153 ITGB2 P05107 Integrin beta-2 chr21 GO:1901214 Not Cancer Driver No 147 0.191 59 9 0.153 15
JAK2 JAK2 O60674 Tyrosine-protein kinase JAK2 chr9 GO:1901214 Census, Compendium Yes 136 0.12 59 5 0.085 5
JUN JUN P05412 Transcription factor Jun chr1 GO:1901214 Census Yes 35 0.106 281 25 0.089 0
KCNB1_ENST00000635465 KCNB1 Q14721 Potassium voltage-gated channel subfamily B member 1 chr20 GO:1901214 Not Cancer Driver No 192 0.224 417 100 0.24 6
KDM2B KDM2B Q8NHM5 Lysine-specific demethylase 2B chr12 GO:1901214 Not Cancer Driver No 187 0.14 617 90 0.146 0
KIF14 KIF14 Q15058 Kinesin-like protein KIF14 chr1 GO:1901214 Not Cancer Driver No 222 0.135 774 102 0.132 2
KMO KMO O15229 Kynurenine 3-monooxygenase chr1 GO:1901214 Not Cancer Driver No 77 0.158 0 0 0.0 0
KRAS KRAS P01116 GTPase KRas chr12 GO:1901214 Census, Compendium Yes 788 4.169 7 2 0.286 27
LANCL1_ENST00000450366 LANCL1 O43813 Glutathione S-transferase LANCL1 chr2 GO:1901214 Not Cancer Driver No 45 0.113 10 0 0.0 0
LGMN_ENST00000334869 LGMN Q99538 Legumain chr14 GO:1901214 Not Cancer Driver No 57 0.132 112 19 0.17 0
LIG4 LIG4 P49917 DNA ligase 4 chr13 GO:1901214 Not Cancer Driver No 134 0.147 63 10 0.159 2
LRRK2 LRRK2 Q5S007 Leucine-rich repeat serine/threonine-protein kinase 2 chr12 GO:1901214 Not Cancer Driver No 519 0.205 90 17 0.189 23
MAG_ENST00000537831 MAG P20916 Myelin-associated glycoprotein chr19 GO:1901214 Not Cancer Driver No 118 0.188 65 7 0.108 1
MAP2K4_ENST00000353533 MAP2K4 P45985 Dual specificity mitogen-activated protein kinase kinase 4 chr17 GO:1901214 Census, Compendium Yes 89 0.223 137 28 0.204 0
MAP2K7_ENST00000397979 MAP2K7 O14733 Dual specificity mitogen-activated protein kinase kinase 7 chr19 GO:1901214 Compendium Yes 89 0.212 144 20 0.139 0
MAP3K11 MAP3K11 Q16584 Mitogen-activated protein kinase kinase kinase 11 chr11 GO:1901214 Not Cancer Driver No 97 0.115 466 54 0.116 0
MAP3K12_ENST00000267079 MAP3K12 Q12852 Mitogen-activated protein kinase kinase kinase 12 chr12 GO:1901214 Not Cancer Driver No 120 0.14 481 64 0.133 0
MAP3K5 MAP3K5 Q99683 Mitogen-activated protein kinase kinase kinase 5 chr6 GO:1901214 Not Cancer Driver No 197 0.143 242 29 0.12 0
MAPT_ENST00000262410 MAPT P10636 Microtubule-associated protein tau chr17 GO:1901214 Not Cancer Driver No 128 0.169 750 126 0.168 18
MCL1 MCL1 Q07820 Induced myeloid leukemia cell differentiation protein Mcl-1 chr1 GO:1901214 Not Cancer Driver No 30 0.086 203 21 0.103 0
MDK_ENST00000407067 MDK P21741 Midkine chr11 GO:1901214 Not Cancer Driver No 15 0.105 20 2 0.1 0
MEAK7 MEAK7 Q6P9B6 MTOR-associated protein MEAK7 chr16 GO:1901214 Not Cancer Driver No 56 0.123 182 24 0.132 0
MECP2_ENST00000303391 MECP2 P51608 Methyl-CpG-binding protein 2 chrX GO:1901214 Not Cancer Driver No 75 0.154 483 74 0.153 46
MEF2C_ENST00000504921 MEF2C Q06413 Myocyte-specific enhancer factor 2C chr5 GO:1901214 Not Cancer Driver No 92 0.195 408 81 0.199 0
MSH2 MSH2 P43246 DNA mismatch repair protein Msh2 chr2 GO:1901214 Census Yes 92 0.099 37 4 0.108 70
MT3 MT3 P25713 Metallothionein-3 chr16 GO:1901214 Not Cancer Driver No 7 0.103 0 0 0.0 0
MTNR1B MTNR1B P49286 Melatonin receptor type 1B chr11 GO:1901214 Not Cancer Driver No 104 0.287 8 1 0.125 0
MYBL2 MYBL2 P10244 Myb-related protein B chr20 GO:1901214 Not Cancer Driver No 111 0.159 506 85 0.168 0
NAE1_ENST00000290810 NAE1 Q13564 NEDD8-activating enzyme E1 regulatory subunit chr16 GO:1901214 Not Cancer Driver No 39 0.073 69 3 0.043 0
NAIP_ENST00000194097 NAIP Q13075 Baculoviral IAP repeat-containing protein 1 chr5 GO:1901214 Not Cancer Driver No 39 0.028 67 4 0.06 0
NCOA7_ENST00000368357 NCOA7 Q8NI08 Nuclear receptor coactivator 7 chr6 GO:1901214 Not Cancer Driver No 110 0.117 538 63 0.117 0
NDNF NDNF Q8TB73 Protein NDNF chr4 GO:1901214 Not Cancer Driver No 125 0.22 129 29 0.225 1
NEFL NEFL P07196 Neurofilament light polypeptide chr8 GO:1901214 Not Cancer Driver No 92 0.169 285 39 0.137 12
NES NES P48681 Nestin chr1 GO:1901214 Not Cancer Driver No 271 0.167 1474 253 0.172 0
NF1 NF1 P21359 Neurofibromin chr17 GO:1901214 Census, Compendium Yes 375 0.132 406 47 0.116 85
NFATC4_ENST00000250373 NFATC4 Q14934 Nuclear factor of activated T-cells, cytoplasmic 4 chr14 GO:1901214 Not Cancer Driver No 155 0.172 685 120 0.175 0
NGF NGF P01138 Beta-nerve growth factor chr1 GO:1901214 Not Cancer Driver No 66 0.274 93 25 0.269 1
NONO NONO Q15233 Non-POU domain-containing octamer-binding protein chrX GO:1901214 Census, Compendium Yes 101 0.214 349 64 0.183 0
NQO1 NQO1 P15559 NAD(P)H dehydrogenase [quinone] 1 chr16 GO:1901214 Not Cancer Driver No 21 0.077 10 1 0.1 0
NR4A2_ENST00000409572 NR4A2 P43354 Nuclear receptor subfamily 4 group A member 2 chr2 GO:1901214 Not Cancer Driver No 110 0.184 261 38 0.146 0
NR4A3_ENST00000395097 NR4A3 Q92570 Nuclear receptor subfamily 4 group A member 3 chr9 GO:1901214 Census Yes 83 0.133 298 37 0.124 0
NRBP2 NRBP2 Q9NSY0 Nuclear receptor-binding protein 2 chr8 GO:1901214 Not Cancer Driver No 30 0.06 110 5 0.045 0
NRP1 NRP1 O14786 Neuropilin-1 chr10 GO:1901214 Compendium Yes 146 0.158 211 31 0.147 0
NSMF NSMF Q6X4W1 NMDA receptor synaptonuclear signaling and neuronal migration factor chr9 GO:1901214 Not Cancer Driver No 46 0.087 287 19 0.066 2
NTF3_ENST00000331010 NTF3 P20783 Neurotrophin-3 chr12 GO:1901214 Not Cancer Driver No 52 0.202 99 21 0.212 0
NTF4 NTF4 P34130 Neurotrophin-4 chr19 GO:1901214 Not Cancer Driver No 21 0.1 56 4 0.071 0
NTRK1 NTRK1 P04629 High affinity nerve growth factor receptor chr1 GO:1901214 Census, Compendium Yes 168 0.211 57 8 0.14 25
NTRK2_ENST00000323115 NTRK2 Q16620 BDNF/NT-3 growth factors receptor chr9 GO:1901214 Not Cancer Driver No 155 0.189 117 18 0.154 1
NUPR1_ENST00000324873 NUPR1 O60356 Nuclear protein 1 chr16 GO:1901214 Not Cancer Driver No 10 0.122 82 10 0.122 0
OXR1 OXR1 Q8N573 Oxidation resistance protein 1 chr8 GO:1901214 Not Cancer Driver No 126 0.144 544 76 0.14 0
PAK3_ENST00000262836 PAK3 O75914 Serine/threonine-protein kinase PAK 3 chrX GO:1901214 Not Cancer Driver No 127 0.227 286 64 0.224 2
PARK7_ENST00000377488 PARK7 Q99497 Parkinson disease protein 7 chr1 GO:1901214 Not Cancer Driver No 11 0.058 30 0 0.0 5
PARP1 PARP1 P09874 Poly [ADP-ribose] polymerase 1 chr1 GO:1901214 Not Cancer Driver No 119 0.117 320 34 0.106 0
PCDHGC3 PCDHGC3 Q9UN70 Protocadherin gamma-C3 chr5 GO:1901214 Not Cancer Driver No 113 0.121 367 34 0.093 0
PCDHGC4 PCDHGC4 Q9Y5F7 Protocadherin gamma-C4 chr5 GO:1901214 Not Cancer Driver No 136 0.145 460 59 0.128 0
PCDHGC5 PCDHGC5 Q9Y5F6 Protocadherin gamma-C5 chr5 GO:1901214 Not Cancer Driver No 135 0.143 492 72 0.146 0
PCSK9 PCSK9 Q8NBP7 Proprotein convertase subtilisin/kexin type 9 chr1 GO:1901214 Not Cancer Driver No 86 0.124 148 27 0.182 9
PICALM PICALM Q13492 Phosphatidylinositol-binding clathrin assembly protein chr11 GO:1901214 Census Yes 89 0.137 320 42 0.131 0
PIK3CA PIK3CA P42336 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform chr3 GO:1901214 Census, Compendium Yes 1669 1.563 38 11 0.289 30
PINK1 PINK1 Q9BXM7 Serine/threonine-protein kinase PINK1, mitochondrial chr1 GO:1901214 Not Cancer Driver No 57 0.098 99 13 0.131 23
PITX3_ENST00000539804 PITX3 O75364 Pituitary homeobox 3 chr10 GO:1901214 Not Cancer Driver No 24 0.079 155 12 0.077 1
PLA2G3 PLA2G3 Q9NZ20 Group 3 secretory phospholipase A2 chr22 GO:1901214 Not Cancer Driver No 115 0.226 175 39 0.223 0
POU4F1 POU4F1 Q01851 POU domain, class 4, transcription factor 1 chr13 GO:1901214 Not Cancer Driver No 51 0.122 273 34 0.125 1
PPARGC1A PPARGC1A Q9UBK2 Peroxisome proliferator-activated receptor gamma coactivator 1-alpha chr4 GO:1901214 Not Cancer Driver No 181 0.227 609 148 0.243 0
PPT1 PPT1 P50897 Palmitoyl-protein thioesterase 1 chr1 GO:1901214 Not Cancer Driver No 37 0.121 0 0 0.0 23
PRKCG PRKCG P05129 Protein kinase C gamma type chr19 GO:1901214 Not Cancer Driver No 172 0.247 151 43 0.285 5
PRKCI PRKCI P41743 Protein kinase C iota type chr3 GO:1901214 Not Cancer Driver No 110 0.185 120 16 0.133 0
PRKN PRKN O60260 E3 ubiquitin-protein ligase parkin chr6 GO:1901214 Not Cancer Driver No 110 0.237 78 15 0.192 31
PRNP PRNP P04156 Major prion protein chr20 GO:1901214 Not Cancer Driver No 36 0.142 115 7 0.061 18
PSEN1 PSEN1 P49768 Presenilin-1 chr14 GO:1901214 Not Cancer Driver No 61 0.131 134 21 0.157 96
PTK2B_ENST00000346049 PTK2B Q14289 Protein-tyrosine kinase 2-beta chr8 GO:1901214 Not Cancer Driver No 161 0.16 261 37 0.142 0
PTPRZ1 PTPRZ1 P23471 Receptor-type tyrosine-protein phosphatase zeta chr7 GO:1901214 Not Cancer Driver No 480 0.207 978 216 0.221 0
RAB29 RAB29 O14966 Ras-related protein Rab-7L1 chr1 GO:1901214 Not Cancer Driver No 28 0.138 18 3 0.167 0
RACK1 RACK1 P63244 Receptor of activated protein C kinase 1 chr5 GO:1901214 Not Cancer Driver No 34 0.107 13 0 0.0 0
RAPSN RAPSN Q13702 43 kDa receptor-associated protein of the synapse chr11 GO:1901214 Not Cancer Driver No 38 0.092 10 0 0.0 8
RASA1 RASA1 P20936 Ras GTPase-activating protein 1 chr5 GO:1901214 Compendium Yes 154 0.147 181 25 0.138 3
REST REST Q13127 RE1-silencing transcription factor chr4 GO:1901214 Not Cancer Driver No 142 0.129 868 113 0.13 4
RETREG1 RETREG1 Q9H6L5 Reticulophagy regulator 1 chr5 GO:1901214 Not Cancer Driver No 48 0.097 245 21 0.086 0
RHOA RHOA P61586 Transforming protein RhoA chr3 GO:1901214 Census, Compendium Yes 99 0.513 46 13 0.283 2
RILPL1 RILPL1 Q5EBL4 RILP-like protein 1 chr12 GO:1901214 Not Cancer Driver No 46 0.114 269 36 0.134 0
ROCK1 ROCK1 Q13464 Rho-associated protein kinase 1 chr18 GO:1901214 Not Cancer Driver No 184 0.136 780 103 0.132 0
RRAS2 RRAS2 P62070 Ras-related protein R-Ras2 chr11 GO:1901214 Compendium Yes 29 0.142 37 1 0.027 4
SARM1 SARM1 Q6SZW1 NAD(+) hydrolase SARM1 chr17 GO:1901214 Not Cancer Driver No 36 0.05 80 4 0.05 0
SET SET Q01105 Protein SET chr9 GO:1901214 Census, Compendium Yes 35 0.121 221 26 0.118 2
SIGMAR1 SIGMAR1 Q99720 Sigma non-opioid intracellular receptor 1 chr9 GO:1901214 Not Cancer Driver No 22 0.099 2 0 0.0 1
SIX1_ENST00000645694 SIX1 Q15475 Homeobox protein SIX1 chr14 GO:1901214 Census, Compendium Yes 49 0.173 144 25 0.174 8
SIX4 SIX4 Q9UIU6 Homeobox protein SIX4 chr14 GO:1901214 Not Cancer Driver No 99 0.127 460 58 0.126 0
SLC1A1 SLC1A1 P43005 Excitatory amino acid transporter 3 chr9 GO:1901214 Not Cancer Driver No 69 0.132 17 4 0.235 1
SLC30A10 SLC30A10 Q6XR72 Zinc transporter 10 chr1 GO:1901214 Not Cancer Driver No 68 0.14 61 10 0.164 2
SLC7A11 SLC7A11 Q9UPY5 Cystine/glutamate transporter chr4 GO:1901214 Not Cancer Driver No 70 0.14 15 2 0.133 0
SNCA_ENST00000506244 SNCA P37840 Alpha-synuclein chr4 GO:1901214 Not Cancer Driver No 21 0.15 107 13 0.121 5
SNCB_ENST00000510387 SNCB Q16143 Beta-synuclein chr5 GO:1901214 Not Cancer Driver No 23 0.172 110 21 0.191 0
SNCG SNCG O76070 Gamma-synuclein chr10 GO:1901214 Not Cancer Driver No 11 0.087 111 10 0.09 0
SNX6 SNX6 Q9UNH7 Sorting nexin-6 chr14 GO:1901214 Not Cancer Driver No 33 0.081 85 7 0.082 0
SOD1 SOD1 P00441 Superoxide dismutase [Cu-Zn] chr21 GO:1901214 Not Cancer Driver No 16 0.104 93 9 0.097 79
SOD2_ENST00000367055 SOD2 P04179 Superoxide dismutase [Mn], mitochondrial chr6 GO:1901214 Not Cancer Driver No 32 0.144 25 5 0.2 0
SRPK2_ENST00000489828 SRPK2 P78362 SRSF protein kinase 2 chr7 GO:1901214 Not Cancer Driver No 78 0.113 343 46 0.134 0
ST8SIA2 ST8SIA2 Q92186 Alpha-2,8-sialyltransferase 8B chr15 GO:1901214 Not Cancer Driver No 84 0.224 38 8 0.211 0
STAMBP_ENST00000339566 STAMBP O95630 STAM-binding protein chr2 GO:1901214 Not Cancer Driver No 51 0.12 139 16 0.115 6
STXBP1_ENST00000373299 STXBP1 P61764 Syntaxin-binding protein 1 chr9 GO:1901214 Not Cancer Driver No 97 0.163 111 23 0.207 18
SYNGAP1_ENST00000646630 SYNGAP1 Q96PV0 Ras/Rap GTPase-activating protein SynGAP chr6 GO:1901214 Not Cancer Driver No 153 0.114 830 90 0.108 2
TBK1 TBK1 Q9UHD2 Serine/threonine-protein kinase TBK1 chr12 GO:1901214 Not Cancer Driver No 101 0.139 42 5 0.119 12
TERT TERT O14746 Telomerase reverse transcriptase chr5 GO:1901214 Census Yes 110 0.097 212 16 0.075 31
TFAP2A TFAP2A P05549 Transcription factor AP-2-alpha chr6 GO:1901214 Not Cancer Driver No 77 0.176 275 44 0.16 4
TFAP2B TFAP2B Q92481 Transcription factor AP-2-beta chr6 GO:1901214 Not Cancer Driver No 114 0.248 306 75 0.245 6
TFAP2D TFAP2D Q7Z6R9 Transcription factor AP-2-delta chr6 GO:1901214 Not Cancer Driver No 164 0.363 161 54 0.335 0
TGFB2_ENST00000366930 TGFB2 P61812 Transforming growth factor beta-2 proprotein chr1 GO:1901214 Not Cancer Driver No 63 0.152 47 8 0.17 3
TGFB3 TGFB3 P10600 Transforming growth factor beta-3 proprotein chr14 GO:1901214 Not Cancer Driver No 45 0.109 96 14 0.146 1
TLR4_ENST00000355622 TLR4 O00206 Toll-like receptor 4 chr9 GO:1901214 Not Cancer Driver No 292 0.348 0 0 0.0 0
TLR6 TLR6 Q9Y2C9 Toll-like receptor 6 chr4 GO:1901214 Not Cancer Driver No 99 0.124 1 0 0.0 0
TNF TNF P01375 Tumor necrosis factor chr6 GO:1901214 Not Cancer Driver No 24 0.103 45 3 0.067 0
TOX3 TOX3 O15405 TOX high mobility group box family member 3 chr16 GO:1901214 Not Cancer Driver No 85 0.148 485 72 0.148 0
TP53_ENST00000445888 TP53 P04637 Cellular tumor antigen p53 chr17 GO:1901214 Census, Compendium Yes 2891 7.356 282 1466 5.199 83
TREM2 TREM2 Q9NZC2 Triggering receptor expressed on myeloid cells 2 chr6 GO:1901214 Not Cancer Driver No 43 0.187 27 2 0.074 1
TRIM2_ENST00000437508 TRIM2 Q9C040 Tripartite motif-containing protein 2 chr4 GO:1901214 Not Cancer Driver No 86 0.116 238 38 0.16 1
TRPM2_ENST00000397928 TRPM2 O94759 Transient receptor potential cation channel subfamily M member 2 chr21 GO:1901214 Not Cancer Driver No 286 0.19 266 44 0.165 0
TSC1 TSC1 Q92574 Hamartin chr9 GO:1901214 Census, Compendium Yes 135 0.116 732 78 0.107 11
TYRO3 TYRO3 Q06418 Tyrosine-protein kinase receptor TYRO3 chr15 GO:1901214 Not Cancer Driver No 119 0.134 197 17 0.086 0
TYROBP TYROBP O43914 TYRO protein tyrosine kinase-binding protein chr19 GO:1901214 Not Cancer Driver No 24 0.212 28 8 0.286 0
UBB_ENST00000614404 UBB P0CG47 Polyubiquitin-B chr17 GO:1901214 Not Cancer Driver No 20 0.087 102 8 0.078 0
UBE2M UBE2M P61081 NEDD8-conjugating enzyme Ubc12 chr19 GO:1901214 Not Cancer Driver No 30 0.164 32 6 0.188 0
UNC5B UNC5B Q8IZJ1 Netrin receptor UNC5B chr10 GO:1901214 Not Cancer Driver No 155 0.164 117 20 0.171 0
VSTM2L VSTM2L Q96N03 V-set and transmembrane domain-containing protein 2-like protein chr20 GO:1901214 Not Cancer Driver No 28 0.137 134 19 0.142 0
WFS1_ENST00000503569 WFS1 O76024 Wolframin chr4 GO:1901214 Not Cancer Driver No 105 0.118 203 10 0.049 39
WNT1 WNT1 P04628 Proto-oncogene Wnt-1 chr12 GO:1901214 Not Cancer Driver No 29 0.078 25 0 0.0 8
WNT5A_ENST00000474267 WNT5A P41221 Protein Wnt-5a chr3 GO:1901214 Not Cancer Driver No 66 0.174 0 0 0.0 2
XRCC2 XRCC2 O43543 DNA repair protein XRCC2 chr7 GO:1901214 Not Cancer Driver No 36 0.129 9 1 0.111 2
ZNF746_ENST00000340622 ZNF746 Q6NUN9 Zinc finger protein 746 chr7 GO:1901214 Not Cancer Driver No 93 0.144 436 56 0.128 0
ZPR1 ZPR1 O75312 Zinc finger protein ZPR1 chr11 GO:1901214 Not Cancer Driver No 38 0.083 291 27 0.093 0