Total number of protein in "GO:0071456" GO term: 102
| Identifier | UniProt Gene | UniProt Accession | UniProt Name | Chromosome | GO term | Database | Cancer Driver | Number of missense mutations | Missense mutation per residues | Number of disordered residues | Number of mutations in disordered regions | Disordered missense mutations per residues | Number of OMIM mutation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ACAA2 | ACAA2 | P42765 | 3-ketoacyl-CoA thiolase, mitochondrial | chr18 | GO:0071456 | Not Cancer Driver | No | 42 | 0.106 | 51 | 2 | 0.039 | 0 |
| ADAM8 | ADAM8 | P78325 | Disintegrin and metalloproteinase domain-containing protein 8 | chr10 | GO:0071456 | Not Cancer Driver | No | 82 | 0.1 | 230 | 13 | 0.057 | 0 |
| AK4 | AK4 | P27144 | Adenylate kinase 4, mitochondrial | chr1 | GO:0071456 | Not Cancer Driver | No | 26 | 0.117 | 24 | 3 | 0.125 | 0 |
| ANGPT4 | ANGPT4 | Q9Y264 | Angiopoietin-4 | chr20 | GO:0071456 | Not Cancer Driver | No | 104 | 0.207 | 150 | 32 | 0.213 | 0 |
| AQP1 | AQP1 | P29972 | Aquaporin-1 | chr7 | GO:0071456 | Not Cancer Driver | No | 39 | 0.145 | 4 | 1 | 0.25 | 0 |
| AQP3 | AQP3 | Q92482 | Aquaporin-3 | chr9 | GO:0071456 | Not Cancer Driver | No | 34 | 0.116 | 12 | 0 | 0.0 | 0 |
| ATP7A | ATP7A | Q04656 | Copper-transporting ATPase 1 | chrX | GO:0071456 | Not Cancer Driver | No | 228 | 0.152 | 171 | 46 | 0.269 | 52 |
| BAD_ENST00000309032 | BAD | Q92934 | Bcl2-associated agonist of cell death | chr11 | GO:0071456 | Not Cancer Driver | No | 14 | 0.083 | 163 | 14 | 0.086 | 0 |
| BCL2_ENST00000333681 | BCL2 | P10415 | Apoptosis regulator Bcl-2 | chr18 | GO:0071456 | Census, Compendium | Yes | 24 | 0.1 | 72 | 5 | 0.069 | 0 |
| BMP7 | BMP7 | P18075 | Bone morphogenetic protein 7 | chr20 | GO:0071456 | Not Cancer Driver | No | 91 | 0.211 | 69 | 18 | 0.261 | 0 |
| BNIP3L | BNIP3L | O60238 | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like | chr8 | GO:0071456 | Not Cancer Driver | No | 16 | 0.073 | 175 | 14 | 0.08 | 0 |
| BRIP1 | BRIP1 | Q9BX63 | Fanconi anemia group J protein | chr17 | GO:0071456 | Census | Yes | 174 | 0.139 | 397 | 59 | 0.149 | 6 |
| CARD16 | CARD16 | Q5EG05 | Caspase recruitment domain-containing protein 16 | chr11 | GO:0071456 | Not Cancer Driver | No | 36 | 0.183 | 23 | 7 | 0.304 | 0 |
| CASR_ENST00000638421 | CASR | P41180 | Extracellular calcium-sensing receptor | chr3 | GO:0071456 | Not Cancer Driver | No | 304 | 0.282 | 189 | 60 | 0.317 | 108 |
| CCNA2_ENST00000618014 | CCNA2 | P20248 | Cyclin-A2 | chr4 | GO:0071456 | Not Cancer Driver | No | 45 | 0.104 | 186 | 19 | 0.102 | 0 |
| CFLAR | CFLAR | O15519 | CASP8 and FADD-like apoptosis regulator | chr2 | GO:0071456 | Not Cancer Driver | No | 40 | 0.083 | 44 | 2 | 0.045 | 0 |
| CLCA1 | CLCA1 | A8K7I4 | Calcium-activated chloride channel regulator 1 | chr1 | GO:0071456 | Not Cancer Driver | No | 144 | 0.158 | 212 | 22 | 0.104 | 0 |
| CPEB1_ENST00000611031 | CPEB1 | Q9BZB8 | Cytoplasmic polyadenylation element-binding protein 1 | chr15 | GO:0071456 | Not Cancer Driver | No | 90 | 0.159 | 226 | 37 | 0.164 | 0 |
| CPEB2_ENST00000507071 | CPEB2 | Q7Z5Q1 | Cytoplasmic polyadenylation element-binding protein 2 | chr4 | GO:0071456 | Not Cancer Driver | No | 66 | 0.112 | 269 | 17 | 0.063 | 0 |
| DNMT3A | DNMT3A | Q9Y6K1 | DNA (cytosine-5)-methyltransferase 3A | chr2 | GO:0071456 | Census, Compendium | Yes | 194 | 0.213 | 371 | 59 | 0.159 | 16 |
| E2F1 | E2F1 | Q01094 | Transcription factor E2F1 | chr20 | GO:0071456 | Not Cancer Driver | No | 49 | 0.112 | 272 | 23 | 0.085 | 0 |
| EDN1 | EDN1 | P05305 | Endothelin-1 | chr6 | GO:0071456 | Not Cancer Driver | No | 37 | 0.175 | 97 | 20 | 0.206 | 3 |
| EGLN1 | EGLN1 | Q9GZT9 | Egl nine homolog 1 | chr1 | GO:0071456 | Not Cancer Driver | No | 35 | 0.082 | 206 | 8 | 0.039 | 2 |
| EGLN2_ENST00000303961 | EGLN2 | Q96KS0 | Prolyl hydroxylase EGLN2 | chr19 | GO:0071456 | Not Cancer Driver | No | 52 | 0.128 | 201 | 17 | 0.085 | 0 |
| EGLN3 | EGLN3 | Q9H6Z9 | Prolyl hydroxylase EGLN3 | chr14 | GO:0071456 | Not Cancer Driver | No | 33 | 0.138 | 13 | 0 | 0.0 | 0 |
| ENDOG | ENDOG | Q14249 | Endonuclease G, mitochondrial | chr9 | GO:0071456 | Not Cancer Driver | No | 11 | 0.037 | 61 | 1 | 0.016 | 0 |
| EPAS1 | EPAS1 | Q99814 | Endothelial PAS domain-containing protein 1 | chr2 | GO:0071456 | Census, Compendium | Yes | 120 | 0.138 | 449 | 53 | 0.118 | 6 |
| ERO1A | ERO1A | Q96HE7 | ERO1-like protein alpha | chr14 | GO:0071456 | Not Cancer Driver | No | 48 | 0.103 | 32 | 5 | 0.156 | 0 |
| FABP1 | FABP1 | P07148 | Fatty acid-binding protein, liver | chr2 | GO:0071456 | Not Cancer Driver | No | 34 | 0.268 | 0 | 0 | 0.0 | 0 |
| FAM162A | FAM162A | Q96A26 | Protein FAM162A | chr3 | GO:0071456 | Not Cancer Driver | No | 18 | 0.117 | 53 | 8 | 0.151 | 0 |
| FMN2 | FMN2 | Q9NZ56 | Formin-2 | chr1 | GO:0071456 | Not Cancer Driver | No | 614 | 0.357 | 1322 | 475 | 0.359 | 0 |
| FOXO3 | FOXO3 | O43524 | Forkhead box protein O3 | chr6 | GO:0071456 | Census, Compendium | Yes | 70 | 0.104 | 595 | 68 | 0.114 | 0 |
| GATA6 | GATA6 | Q92908 | Transcription factor GATA-6 | chr18 | GO:0071456 | Not Cancer Driver | No | 57 | 0.096 | 476 | 51 | 0.107 | 10 |
| GNGT1_ENST00000429473 | GNGT1 | P63211 | Guanine nucleotide-binding protein G(T) subunit gamma-T1 | chr7 | GO:0071456 | Not Cancer Driver | No | 14 | 0.189 | 25 | 4 | 0.16 | 0 |
| HIF1A_ENST00000337138 | HIF1A | Q16665 | Hypoxia-inducible factor 1-alpha | chr14 | GO:0071456 | Census | Yes | 118 | 0.143 | 435 | 51 | 0.117 | 0 |
| HILPDA | HILPDA | Q9Y5L2 | Hypoxia-inducible lipid droplet-associated protein | chr7 | GO:0071456 | Not Cancer Driver | No | 5 | 0.079 | 33 | 3 | 0.091 | 0 |
| HIPK2 | HIPK2 | Q9H2X6 | Homeodomain-interacting protein kinase 2 | chr7 | GO:0071456 | Not Cancer Driver | No | 154 | 0.129 | 686 | 96 | 0.14 | 0 |
| HMOX1 | HMOX1 | P09601 | Heme oxygenase 1 | chr22 | GO:0071456 | Not Cancer Driver | No | 46 | 0.16 | 81 | 13 | 0.16 | 0 |
| HP1BP3 | HP1BP3 | Q5SSJ5 | Heterochromatin protein 1-binding protein 3 | chr1 | GO:0071456 | Not Cancer Driver | No | 58 | 0.105 | 404 | 45 | 0.111 | 0 |
| HYOU1 | HYOU1 | Q9Y4L1 | Hypoxia up-regulated protein 1 | chr11 | GO:0071456 | Not Cancer Driver | No | 132 | 0.132 | 373 | 47 | 0.126 | 0 |
| IRAK1 | IRAK1 | P51617 | Interleukin-1 receptor-associated kinase 1 | chrX | GO:0071456 | Compendium | Yes | 71 | 0.1 | 337 | 39 | 0.116 | 0 |
| KCND2 | KCND2 | Q9NZV8 | Potassium voltage-gated channel subfamily D member 2 | chr7 | GO:0071456 | Not Cancer Driver | No | 220 | 0.349 | 195 | 62 | 0.318 | 0 |
| KCNK2 | KCNK2 | O95069 | Potassium channel subfamily K member 2 | chr1 | GO:0071456 | Not Cancer Driver | No | 109 | 0.256 | 40 | 10 | 0.25 | 0 |
| KCNK3 | KCNK3 | O14649 | Potassium channel subfamily K member 3 | chr2 | GO:0071456 | Not Cancer Driver | No | 54 | 0.137 | 60 | 7 | 0.117 | 6 |
| KCNMB1 | KCNMB1 | Q16558 | Calcium-activated potassium channel subunit beta-1 | chr5 | GO:0071456 | Not Cancer Driver | No | 49 | 0.257 | 0 | 0 | 0.0 | 0 |
| LMNA | LMNA | P02545 | Prelamin-A/C | chr1 | GO:0071456 | Census | Yes | 68 | 0.102 | 544 | 49 | 0.09 | 131 |
| MDM2_ENST00000539479 | MDM2 | Q00987 | E3 ubiquitin-protein ligase Mdm2 | chr12 | GO:0071456 | Census, Compendium | Yes | 56 | 0.114 | 297 | 37 | 0.125 | 0 |
| MDM4 | MDM4 | O15151 | Protein Mdm4 | chr1 | GO:0071456 | Census, Compendium | Yes | 57 | 0.116 | 202 | 26 | 0.129 | 1 |
| MGARP | MGARP | Q8TDB4 | Protein MGARP | chr4 | GO:0071456 | Not Cancer Driver | No | 25 | 0.104 | 207 | 22 | 0.106 | 0 |
| MIEF1_ENST00000404569 | MIEF1 | Q9NQG6 | Mitochondrial dynamics protein MID51 | chr22 | GO:0071456 | Not Cancer Driver | No | 65 | 0.14 | 94 | 9 | 0.096 | 0 |
| MPL | MPL | P40238 | Thrombopoietin receptor | chr1 | GO:0071456 | Census | Yes | 77 | 0.121 | 129 | 19 | 0.147 | 14 |
| MT3 | MT3 | P25713 | Metallothionein-3 | chr16 | GO:0071456 | Not Cancer Driver | No | 7 | 0.103 | 0 | 0 | 0.0 | 0 |
| MTOR | MTOR | P42345 | Serine/threonine-protein kinase mTOR | chr1 | GO:0071456 | Census, Compendium | Yes | 379 | 0.149 | 296 | 37 | 0.125 | 18 |
| MYC_ENST00000377970 | MYC | P01106 | Myc proto-oncogene protein | chr8 | GO:0071456 | Census, Compendium | Yes | 80 | 0.182 | 299 | 46 | 0.154 | 0 |
| NDNF | NDNF | Q8TB73 | Protein NDNF | chr4 | GO:0071456 | Not Cancer Driver | No | 125 | 0.22 | 129 | 29 | 0.225 | 1 |
| NDRG1 | NDRG1 | Q92597 | Protein NDRG1 | chr8 | GO:0071456 | Census | Yes | 66 | 0.168 | 140 | 22 | 0.157 | 0 |
| NKX3-1 | NKX3-1 | Q99801 | Homeobox protein Nkx-3.1 | chr8 | GO:0071456 | Not Cancer Driver | No | 35 | 0.15 | 171 | 16 | 0.094 | 0 |
| NOP53 | NOP53 | Q9NZM5 | Ribosome biogenesis protein NOP53 | chr19 | GO:0071456 | Not Cancer Driver | No | 59 | 0.123 | 391 | 41 | 0.105 | 0 |
| NPEPPS | NPEPPS | P55786 | Puromycin-sensitive aminopeptidase | chr17 | GO:0071456 | Compendium | Yes | 102 | 0.111 | 45 | 5 | 0.111 | 0 |
| OPRD1 | OPRD1 | P41143 | Delta-type opioid receptor | chr1 | GO:0071456 | Not Cancer Driver | No | 91 | 0.245 | 30 | 3 | 0.1 | 0 |
| P4HB | P4HB | P07237 | Protein disulfide-isomerase | chr17 | GO:0071456 | Not Cancer Driver | No | 61 | 0.12 | 79 | 15 | 0.19 | 1 |
| PCK1 | PCK1 | P35558 | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | chr20 | GO:0071456 | Not Cancer Driver | No | 142 | 0.228 | 110 | 28 | 0.255 | 1 |
| PGK1 | PGK1 | P00558 | Phosphoglycerate kinase 1 | chrX | GO:0071456 | Not Cancer Driver | No | 61 | 0.146 | 40 | 5 | 0.125 | 9 |
| PHB2 | PHB2 | Q99623 | Prohibitin-2 | chr12 | GO:0071456 | Not Cancer Driver | No | 31 | 0.104 | 26 | 4 | 0.154 | 0 |
| PINK1 | PINK1 | Q9BXM7 | Serine/threonine-protein kinase PINK1, mitochondrial | chr1 | GO:0071456 | Not Cancer Driver | No | 57 | 0.098 | 99 | 13 | 0.131 | 23 |
| PMAIP1 | PMAIP1 | Q13794 | Phorbol-12-myristate-13-acetate-induced protein 1 | chr18 | GO:0071456 | Not Cancer Driver | No | 2 | 0.037 | 23 | 1 | 0.043 | 0 |
| PPARD_ENST00000360694 | PPARD | Q03181 | Peroxisome proliferator-activated receptor delta | chr6 | GO:0071456 | Not Cancer Driver | No | 72 | 0.163 | 69 | 7 | 0.101 | 0 |
| PPARG | PPARG | P37231 | Peroxisome proliferator-activated receptor gamma | chr3 | GO:0071456 | Census | Yes | 72 | 0.143 | 44 | 4 | 0.091 | 3 |
| PRKAA1_ENST00000397128 | PRKAA1 | Q13131 | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | chr5 | GO:0071456 | Not Cancer Driver | No | 72 | 0.129 | 124 | 17 | 0.137 | 0 |
| PRKCE | PRKCE | Q02156 | Protein kinase C epsilon type | chr2 | GO:0071456 | Not Cancer Driver | No | 107 | 0.145 | 170 | 26 | 0.153 | 0 |
| PTEN | PTEN | P60484 | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN | chr10 | GO:0071456 | Census, Compendium | Yes | 505 | 1.253 | 76 | 4 | 0.053 | 41 |
| PTGIS | PTGIS | Q16647 | Prostacyclin synthase | chr20 | GO:0071456 | Not Cancer Driver | No | 102 | 0.204 | 18 | 3 | 0.167 | 0 |
| PTGS2 | PTGS2 | P35354 | Prostaglandin G/H synthase 2 | chr1 | GO:0071456 | Not Cancer Driver | No | 105 | 0.174 | 30 | 5 | 0.167 | 0 |
| RGCC | RGCC | Q9H4X1 | Regulator of cell cycle RGCC | chr13 | GO:0071456 | Not Cancer Driver | No | 9 | 0.066 | 81 | 7 | 0.086 | 0 |
| RORA_ENST00000335670 | RORA | P35398 | Nuclear receptor ROR-alpha | chr15 | GO:0071456 | Not Cancer Driver | No | 57 | 0.109 | 182 | 17 | 0.093 | 4 |
| SCN2A_ENST00000637266 | SCN2A | Q99250 | Sodium channel protein type 2 subunit alpha | chr2 | GO:0071456 | Not Cancer Driver | No | 502 | 0.25 | 435 | 133 | 0.306 | 65 |
| SFRP1 | SFRP1 | Q8N474 | Secreted frizzled-related protein 1 | chr8 | GO:0071456 | Not Cancer Driver | No | 40 | 0.127 | 39 | 7 | 0.179 | 0 |
| SIRT1 | SIRT1 | Q96EB6 | NAD-dependent protein deacetylase sirtuin-1 | chr10 | GO:0071456 | Not Cancer Driver | No | 70 | 0.094 | 435 | 31 | 0.071 | 0 |
| SIRT2 | SIRT2 | Q8IXJ6 | NAD-dependent protein deacetylase sirtuin-2 | chr19 | GO:0071456 | Not Cancer Driver | No | 56 | 0.144 | 85 | 17 | 0.2 | 0 |
| SIRT4 | SIRT4 | Q9Y6E7 | NAD-dependent protein lipoamidase sirtuin-4, mitochondrial | chr12 | GO:0071456 | Not Cancer Driver | No | 46 | 0.146 | 4 | 0 | 0.0 | 0 |
| SLC29A1_ENST00000371708 | SLC29A1 | Q99808 | Equilibrative nucleoside transporter 1 | chr6 | GO:0071456 | Not Cancer Driver | No | 51 | 0.112 | 27 | 4 | 0.148 | 0 |
| SLC2A4 | SLC2A4 | P14672 | Solute carrier family 2, facilitated glucose transporter member 4 | chr17 | GO:0071456 | Not Cancer Driver | No | 71 | 0.139 | 43 | 8 | 0.186 | 1 |
| SLC8A1_ENST00000332839 | SLC8A1 | P32418 | Sodium/calcium exchanger 1 | chr2 | GO:0071456 | Not Cancer Driver | No | 305 | 0.313 | 158 | 48 | 0.304 | 0 |
| SLC8A3 | SLC8A3 | P57103 | Sodium/calcium exchanger 3 | chr14 | GO:0071456 | Not Cancer Driver | No | 263 | 0.284 | 152 | 35 | 0.23 | 0 |
| SLC9A1 | SLC9A1 | P19634 | Sodium/hydrogen exchanger 1 | chr1 | GO:0071456 | Not Cancer Driver | No | 89 | 0.109 | 251 | 29 | 0.116 | 1 |
| SRC_ENST00000358208 | SRC | P12931 | Proto-oncogene tyrosine-protein kinase Src | chr20 | GO:0071456 | Census | Yes | 53 | 0.099 | 130 | 11 | 0.085 | 1 |
| STC1 | STC1 | P52823 | Stanniocalcin-1 | chr8 | GO:0071456 | Not Cancer Driver | No | 59 | 0.239 | 58 | 12 | 0.207 | 0 |
| STC2 | STC2 | O76061 | Stanniocalcin-2 | chr5 | GO:0071456 | Not Cancer Driver | No | 71 | 0.235 | 112 | 29 | 0.259 | 0 |
| STUB1 | STUB1 | Q9UNE7 | E3 ubiquitin-protein ligase CHIP | chr16 | GO:0071456 | Not Cancer Driver | No | 35 | 0.116 | 112 | 14 | 0.125 | 12 |
| SUV39H1_ENST00000376687 | SUV39H1 | O43463 | Histone-lysine N-methyltransferase SUV39H1 | chrX | GO:0071456 | Not Cancer Driver | No | 59 | 0.143 | 15 | 1 | 0.067 | 0 |
| SUV39H2 | SUV39H2 | Q9H5I1 | Histone-lysine N-methyltransferase SUV39H2 | chr10 | GO:0071456 | Not Cancer Driver | No | 39 | 0.095 | 23 | 1 | 0.043 | 0 |
| TBL2 | TBL2 | Q9Y4P3 | Transducin beta-like protein 2 | chr7 | GO:0071456 | Not Cancer Driver | No | 68 | 0.152 | 115 | 13 | 0.113 | 0 |
| TERT | TERT | O14746 | Telomerase reverse transcriptase | chr5 | GO:0071456 | Census | Yes | 110 | 0.097 | 212 | 16 | 0.075 | 31 |
| TIGAR | TIGAR | Q9NQ88 | Fructose-2,6-bisphosphatase TIGAR | chr12 | GO:0071456 | Not Cancer Driver | No | 44 | 0.163 | 39 | 9 | 0.231 | 0 |
| TP53_ENST00000445888 | TP53 | P04637 | Cellular tumor antigen p53 | chr17 | GO:0071456 | Census, Compendium | Yes | 2891 | 7.356 | 282 | 1466 | 5.199 | 83 |
| TREM2 | TREM2 | Q9NZC2 | Triggering receptor expressed on myeloid cells 2 | chr6 | GO:0071456 | Not Cancer Driver | No | 43 | 0.187 | 27 | 2 | 0.074 | 1 |
| TWIST1 | TWIST1 | Q15672 | Twist-related protein 1 | chr7 | GO:0071456 | Not Cancer Driver | No | 23 | 0.114 | 132 | 11 | 0.083 | 7 |
| UBQLN1 | UBQLN1 | Q9UMX0 | Ubiquilin-1 | chr9 | GO:0071456 | Not Cancer Driver | No | 64 | 0.109 | 543 | 58 | 0.107 | 0 |
| UCN3 | UCN3 | Q969E3 | Urocortin-3 | chr10 | GO:0071456 | Not Cancer Driver | No | 22 | 0.137 | 74 | 11 | 0.149 | 0 |
| VASN | VASN | Q6EMK4 | Vasorin | chr16 | GO:0071456 | Not Cancer Driver | No | 37 | 0.055 | 233 | 8 | 0.034 | 0 |
| VEGFA_ENST00000523873 | VEGFA | P15692 | Vascular endothelial growth factor A | chr6 | GO:0071456 | Not Cancer Driver | No | 27 | 0.116 | 41 | 7 | 0.171 | 0 |
| ZFP36L1 | ZFP36L1 | Q07352 | mRNA decay activator protein ZFP36L1 | chr14 | GO:0071456 | Compendium | Yes | 57 | 0.169 | 212 | 30 | 0.142 | 0 |