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Total number of protein in "GO:0071214" GO term:  281

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
ACTR5 ACTR5 Q9H9F9 Actin-related protein 5 chr20 GO:0071214 Not Cancer Driver No 63 0.104 163 23 0.141 0
ADSS ADSS2 P30520 Adenylosuccinate synthetase isozyme 2 chr1 GO:0071214 Not Cancer Driver No 49 0.107 48 4 0.083 0
AGT AGT P01019 Angiotensinogen chr1 GO:0071214 Not Cancer Driver No 85 0.179 33 10 0.303 1
AKR1B1 AKR1B1 P15121 Aldo-keto reductase family 1 member B1 chr7 GO:0071214 Not Cancer Driver No 52 0.165 19 1 0.053 0
AKT2 AKT2 P31751 RAC-beta serine/threonine-protein kinase chr19 GO:0071214 Census Yes 77 0.16 84 9 0.107 2
ANKRD1 ANKRD1 Q15327 Ankyrin repeat domain-containing protein 1 chr10 GO:0071214 Not Cancer Driver No 52 0.163 83 13 0.157 0
AQP1 AQP1 P29972 Aquaporin-1 chr7 GO:0071214 Not Cancer Driver No 39 0.145 4 1 0.25 0
AQP10 AQP10 Q96PS8 Aquaporin-10 chr1 GO:0071214 Not Cancer Driver No 73 0.243 15 1 0.067 0
AQP2 AQP2 P41181 Aquaporin-2 chr12 GO:0071214 Not Cancer Driver No 52 0.192 31 3 0.097 28
AQP5 AQP5 P55064 Aquaporin-5 chr12 GO:0071214 Not Cancer Driver No 31 0.117 21 2 0.095 5
ARHGEF2 ARHGEF2 Q92974 Rho guanine nucleotide exchange factor 2 chr1 GO:0071214 Not Cancer Driver No 146 0.148 450 70 0.156 0
ASCL1 ASCL1 P50553 Achaete-scute homolog 1 chr12 GO:0071214 Not Cancer Driver No 33 0.14 182 24 0.132 0
ASIC1_ENST00000447966 ASIC1 P78348 Acid-sensing ion channel 1 chr12 GO:0071214 Not Cancer Driver No 69 0.131 17 2 0.118 0
ATF4_ENST00000404241 ATF4 P18848 Cyclic AMP-dependent transcription factor ATF-4 chr22 GO:0071214 Not Cancer Driver No 53 0.151 259 38 0.147 0
ATM_ENST00000452508 ATM Q13315 Serine-protein kinase ATM chr11 GO:0071214 Census, Compendium Yes 469 0.153 225 39 0.173 41
ATP1A2 ATP1A2 P50993 Sodium/potassium-transporting ATPase subunit alpha-2 chr1 GO:0071214 Not Cancer Driver No 230 0.225 161 34 0.211 8
ATR ATR Q13535 Serine/threonine-protein kinase ATR chr3 GO:0071214 Census, Compendium Yes 338 0.128 106 14 0.132 1
AURKB_ENST00000585124 AURKB Q96GD4 Aurora kinase B chr17 GO:0071214 Not Cancer Driver No 51 0.148 63 8 0.127 0
AVPR1A AVPR1A P37288 Vasopressin V1a receptor chr12 GO:0071214 Not Cancer Driver No 105 0.251 68 25 0.368 0
BABAM2_ENST00000342045 BABAM2 Q9NXR7 BRISC and BRCA1-A complex member 2 chr2 GO:0071214 Not Cancer Driver No 52 0.136 0 0 0.0 0
BAD_ENST00000309032 BAD Q92934 Bcl2-associated agonist of cell death chr11 GO:0071214 Not Cancer Driver No 14 0.083 163 14 0.086 0
BAG3 BAG3 O95817 BAG family molecular chaperone regulator 3 chr10 GO:0071214 Not Cancer Driver No 57 0.099 571 57 0.1 7
BAK1 BAK1 Q16611 Bcl-2 homologous antagonist/killer chr6 GO:0071214 Not Cancer Driver No 38 0.18 58 9 0.155 0
BARD1 BARD1 Q99728 BRCA1-associated RING domain protein 1 chr2 GO:0071214 Census Yes 96 0.124 384 49 0.128 0
BAX_ENST00000345358 BAX Q07812 Apoptosis regulator BAX chr19 GO:0071214 Census Yes 30 0.156 39 2 0.051 0
BCL10 BCL10 O95999 B-cell lymphoma/leukemia 10 chr1 GO:0071214 Census, Compendium Yes 36 0.155 151 25 0.166 0
BCL2L1 BCL2L1 Q07817 Bcl-2-like protein 1 chr20 GO:0071214 Not Cancer Driver No 29 0.124 55 3 0.055 0
BLM BLM P54132 Bloom syndrome protein chr15 GO:0071214 Census Yes 153 0.108 667 70 0.105 8
BMF_ENST00000561360 BMF Q96LC9 Bcl-2-modifying factor chr15 GO:0071214 Not Cancer Driver No 22 0.12 94 9 0.096 0
BMP6 BMP6 P22004 Bone morphogenetic protein 6 chr6 GO:0071214 Not Cancer Driver No 95 0.185 226 51 0.226 0
BRCA1_ENST00000357654 BRCA1 P38398 Breast cancer type 1 susceptibility protein chr17 GO:0071214 Census, Compendium Yes 224 0.12 1458 174 0.119 35
BRCA2_ENST00000544455 BRCA2 P51587 Breast cancer type 2 susceptibility protein chr13 GO:0071214 Census, Compendium Yes 457 0.134 1542 225 0.146 46
BRCC3 BRCC3 P46736 Lys-63-specific deubiquitinase BRCC36 chrX GO:0071214 Not Cancer Driver No 39 0.123 74 7 0.095 0
CAB39 CAB39 Q9Y376 Calcium-binding protein 39 chr2 GO:0071214 Not Cancer Driver No 31 0.091 43 5 0.116 0
CAPN3 CAPN3 P20807 Calpain-3 chr15 GO:0071214 Not Cancer Driver No 111 0.135 168 11 0.065 52
CARD16 CARD16 Q5EG05 Caspase recruitment domain-containing protein 16 chr11 GO:0071214 Not Cancer Driver No 36 0.183 23 7 0.304 0
CASP1 CASP1 P29466 Caspase-1 chr11 GO:0071214 Not Cancer Driver No 79 0.196 87 18 0.207 0
CASP2 CASP2 P42575 Caspase-2 chr7 GO:0071214 Not Cancer Driver No 63 0.139 42 12 0.286 0
CASP3 CASP3 P42574 Caspase-3 chr4 GO:0071214 Census Yes 32 0.116 62 5 0.081 0
CASP5_ENST00000260315 CASP5 P51878 Caspase-5 chr11 GO:0071214 Not Cancer Driver No 103 0.237 61 17 0.279 0
CASP8AP2 CASP8AP2 Q9UKL3 CASP8-associated protein 2 chr6 GO:0071214 Not Cancer Driver No 219 0.11 1501 178 0.119 0
CASP8_ENST00000432109 CASP8 Q14790 Caspase-8 chr2 GO:0071214 Census, Compendium Yes 142 0.296 106 12 0.113 1
CASP9 CASP9 P55211 Caspase-9 chr1 GO:0071214 Census Yes 49 0.118 71 7 0.099 0
CD40 CD40 P25942 Tumor necrosis factor receptor superfamily member 5 chr20 GO:0071214 Not Cancer Driver No 39 0.141 56 6 0.107 2
CDC25A CDC25A P30304 M-phase inducer phosphatase 1 chr3 GO:0071214 Not Cancer Driver No 63 0.12 313 35 0.112 0
CDKN1A_ENST00000373711 CDKN1A P38936 Cyclin-dependent kinase inhibitor 1 chr6 GO:0071214 Census, Compendium Yes 48 0.293 121 30 0.248 0
CERS1_ENST00000623882 CERS1 P27544 Ceramide synthase 1 chr19 GO:0071214 Not Cancer Driver No 29 0.083 19 0 0.0 1
CHEK1_ENST00000428830 CHEK1 O14757 Serine/threonine-protein kinase Chk1 chr11 GO:0071214 Not Cancer Driver No 58 0.122 86 16 0.186 0
CHEK2_ENST00000405598 CHEK2 O96017 Serine/threonine-protein kinase Chk2 chr22 GO:0071214 Census, Compendium Yes 335 0.617 157 130 0.828 13
CHP1 CHP1 Q99653 Calcineurin B homologous protein 1 chr15 GO:0071214 Not Cancer Driver No 27 0.138 70 12 0.171 0
CLOCK CLOCK O15516 Circadian locomoter output cycles protein kaput chr4 GO:0071214 Not Cancer Driver No 83 0.098 458 38 0.083 0
CNN2_ENST00000263097 CNN2 Q99439 Calponin-2 chr19 GO:0071214 Not Cancer Driver No 35 0.113 166 23 0.139 0
COL1A1 COL1A1 P02452 Collagen alpha-1(I) chain chr17 GO:0071214 Census, Compendium Yes 247 0.169 1212 214 0.177 148
COPS9_ENST00000607357 COPS9 Q8WXC6 COP9 signalosome complex subunit 9 chr2 GO:0071214 Not Cancer Driver No 6 0.105 25 3 0.12 0
CRADD_ENST00000332896 CRADD P78560 Death domain-containing protein CRADD chr12 GO:0071214 Not Cancer Driver No 35 0.176 45 5 0.111 1
CREBBP CREBBP Q92793 CREB-binding protein chr16 GO:0071214 Census, Compendium Yes 412 0.169 1796 247 0.138 33
CRIP1_ENST00000409393 CRIP1 P50238 Cysteine-rich protein 1 chr14 GO:0071214 Not Cancer Driver No 6 0.078 8 1 0.125 0
CRY1 CRY1 Q16526 Cryptochrome-1 chr12 GO:0071214 Not Cancer Driver No 76 0.13 91 5 0.055 0
CRY2_ENST00000616080 CRY2 Q49AN0 Cryptochrome-2 chr11 GO:0071214 Not Cancer Driver No 72 0.121 100 12 0.12 0
CRYAB_ENST00000616970 CRYAB P02511 Alpha-crystallin B chain chr11 GO:0071214 Not Cancer Driver No 22 0.126 59 11 0.186 4
CUL4B CUL4B Q13620 Cullin-4B chrX GO:0071214 Not Cancer Driver No 138 0.151 207 38 0.184 2
CYBA CYBA P13498 Cytochrome b-245 light chain chr16 GO:0071214 Not Cancer Driver No 26 0.133 66 2 0.03 12
DAG1_ENST00000515359 DAG1 Q14118 Dystroglycan 1 chr3 GO:0071214 Not Cancer Driver No 102 0.114 485 61 0.126 4
DDB1 DDB1 Q16531 DNA damage-binding protein 1 chr11 GO:0071214 Not Cancer Driver No 126 0.111 50 8 0.16 4
DDB2 DDB2 Q92466 DNA damage-binding protein 2 chr11 GO:0071214 Census, Compendium Yes 45 0.105 70 5 0.071 2
DHX36 DHX36 Q9H2U1 ATP-dependent DNA/RNA helicase DHX36 chr3 GO:0071214 Not Cancer Driver No 159 0.158 222 39 0.176 0
DNM2_ENST00000355667 DNM2 P50570 Dynamin-2 chr19 GO:0071214 Census Yes 138 0.159 270 43 0.159 22
ECT2 ECT2 Q9H8V3 Protein ECT2 chr3 GO:0071214 Not Cancer Driver No 104 0.114 284 33 0.116 0
EEF1D_ENST00000395119 EEF1D P29692 Elongation factor 1-delta chr8 GO:0071214 Not Cancer Driver No 40 0.142 153 22 0.144 0
EGR1 EGR1 P18146 Early growth response protein 1 chr5 GO:0071214 Not Cancer Driver No 78 0.144 501 72 0.144 0
EIF2AK4 EIF2AK4 Q9P2K8 eIF-2-alpha kinase GCN2 chr15 GO:0071214 Not Cancer Driver No 156 0.095 494 44 0.089 2
EIF2S1 EIF2S1 P05198 Eukaryotic translation initiation factor 2 subunit 1 chr14 GO:0071214 Not Cancer Driver No 35 0.111 59 6 0.102 0
ELK1_ENST00000376983 ELK1 P19419 ETS domain-containing protein Elk-1 chrX GO:0071214 Not Cancer Driver No 51 0.119 327 34 0.104 0
ENG ENG P17813 Endoglin chr9 GO:0071214 Not Cancer Driver No 60 0.091 114 15 0.132 32
EP300 EP300 Q09472 Histone acetyltransferase p300 chr22 GO:0071214 Census, Compendium Yes 334 0.138 1790 196 0.109 1
EPO EPO P01588 Erythropoietin chr7 GO:0071214 Not Cancer Driver No 27 0.14 9 1 0.111 1
ERCC1_ENST00000589165 ERCC1 P07992 DNA excision repair protein ERCC-1 chr19 GO:0071214 Not Cancer Driver No 42 0.141 105 14 0.133 1
ERCC4 ERCC4 Q92889 DNA repair endonuclease XPF chr16 GO:0071214 Census Yes 120 0.131 225 27 0.12 15
ERRFI1 ERRFI1 Q9UJM3 ERBB receptor feedback inhibitor 1 chr1 GO:0071214 Not Cancer Driver No 55 0.119 297 37 0.125 0
F11R F11R Q9Y624 Junctional adhesion molecule A chr1 GO:0071214 Not Cancer Driver No 47 0.157 72 15 0.208 0
FADD FADD Q13158 FAS-associated death domain protein chr11 GO:0071214 Not Cancer Driver No 26 0.125 45 10 0.222 1
FAS FAS P25445 Tumor necrosis factor receptor superfamily member 6 chr10 GO:0071214 Census, Compendium Yes 55 0.164 62 18 0.29 22
FBXO4 FBXO4 Q9UKT5 F-box only protein 4 chr5 GO:0071214 Not Cancer Driver No 55 0.142 68 7 0.103 0
FIGNL1 FIGNL1 Q6PIW4 Fidgetin-like protein 1 chr7 GO:0071214 Not Cancer Driver No 75 0.111 224 23 0.103 0
FMR1 FMR1 Q06787 Synaptic functional regulator FMR1 chrX GO:0071214 Not Cancer Driver No 124 0.196 327 70 0.214 3
GADD45A GADD45A P24522 Growth arrest and DNA damage-inducible protein GADD45 alpha chr1 GO:0071214 Not Cancer Driver No 10 0.061 39 5 0.128 0
GCLC GCLC P48506 Glutamate--cysteine ligase catalytic subunit chr6 GO:0071214 Not Cancer Driver No 73 0.115 167 18 0.108 3
GJA1 GJA1 P17302 Gap junction alpha-1 protein chr6 GO:0071214 Not Cancer Driver No 86 0.225 110 26 0.236 50
GNA11 GNA11 P29992 Guanine nucleotide-binding protein subunit alpha-11 chr19 GO:0071214 Census, Compendium Yes 48 0.134 10 0 0.0 5
GNAT1 GNAT1 P11488 Guanine nucleotide-binding protein G(t) subunit alpha-1 chr3 GO:0071214 Not Cancer Driver No 43 0.123 39 6 0.154 3
GNB5 GNB5 O14775 Guanine nucleotide-binding protein subunit beta-5 chr15 GO:0071214 Not Cancer Driver No 60 0.152 16 1 0.062 1
GPLD1 GPLD1 P80108 Phosphatidylinositol-glycan-specific phospholipase D chr6 GO:0071214 Not Cancer Driver No 153 0.182 36 9 0.25 0
GPR68_ENST00000535815 GPR68 Q15743 Ovarian cancer G-protein coupled receptor 1 chr14 GO:0071214 Not Cancer Driver No 42 0.115 45 1 0.022 1
GRB2_ENST00000392564 GRB2 P62993 Growth factor receptor-bound protein 2 chr17 GO:0071214 Not Cancer Driver No 28 0.129 10 1 0.1 0
GRK1 GRK1 Q15835 Rhodopsin kinase GRK1 chr13 GO:0071214 Not Cancer Driver No 70 0.124 32 2 0.062 2
GRM1_ENST00000282753 GRM1 Q13255 Metabotropic glutamate receptor 1 chr6 GO:0071214 Not Cancer Driver No 346 0.29 339 91 0.268 3
GTF2H5 GTF2H5 Q6ZYL4 General transcription factor IIH subunit 5 chr6 GO:0071214 Not Cancer Driver No 7 0.099 0 0 0.0 1
H2AFX H2AX P16104 Histone H2AX chr11 GO:0071214 Not Cancer Driver No 20 0.14 68 10 0.147 0
HABP4 HABP4 Q5JVS0 Intracellular hyaluronan-binding protein 4 chr9 GO:0071214 Not Cancer Driver No 32 0.077 413 32 0.077 0
HAMP_ENST00000222304 HAMP P81172 Hepcidin chr19 GO:0071214 Not Cancer Driver No 7 0.083 4 0 0.0 4
HIST3H2A H2AW Q7L7L0 Histone H2A type 3 chr1 GO:0071214 Not Cancer Driver No 21 0.162 61 10 0.164 0
HPCA HPCA P84074 Neuron-specific calcium-binding protein hippocalcin chr1 GO:0071214 Not Cancer Driver No 24 0.124 42 4 0.095 3
HRAS HRAS P01112 GTPase HRas chr11 GO:0071214 Census, Compendium Yes 107 0.566 16 4 0.25 18
HSF1 HSF1 Q00613 Heat shock factor protein 1 chr8 GO:0071214 Not Cancer Driver No 59 0.112 335 37 0.11 0
HSPA5 HSPA5 P11021 Endoplasmic reticulum chaperone BiP chr9 GO:0071214 Not Cancer Driver No 73 0.112 282 35 0.124 0
HUS1 HUS1 O60921 Checkpoint protein HUS1 chr7 GO:0071214 Not Cancer Driver No 25 0.089 17 2 0.118 0
HVCN1_ENST00000620084 HVCN1 Q96D96 Voltage-gated hydrogen channel 1 chr12 GO:0071214 Not Cancer Driver No 51 0.187 52 13 0.25 0
HYAL1_ENST00000395144 HYAL1 Q12794 Hyaluronidase-1 chr3 GO:0071214 Not Cancer Driver No 47 0.108 9 0 0.0 1
HYAL2_ENST00000357750 HYAL2 Q12891 Hyaluronidase-2 chr3 GO:0071214 Not Cancer Driver No 52 0.11 8 1 0.125 0
HYAL3 HYAL3 O43820 Hyaluronidase-3 chr3 GO:0071214 Not Cancer Driver No 48 0.115 10 0 0.0 0
IFI16_ENST00000295809 IFI16 Q16666 Gamma-interferon-inducible protein 16 chr1 GO:0071214 Not Cancer Driver No 155 0.197 419 90 0.215 0
IGF1R IGF1R P08069 Insulin-like growth factor 1 receptor chr15 GO:0071214 Not Cancer Driver No 183 0.134 265 37 0.14 6
IL13 IL13 P35225 Interleukin-13 chr5 GO:0071214 Not Cancer Driver No 20 0.137 0 0 0.0 0
IL1B IL1B P01584 Interleukin-1 beta chr2 GO:0071214 Not Cancer Driver No 39 0.145 16 3 0.188 0
IMPACT IMPACT Q9P2X3 Protein IMPACT chr18 GO:0071214 Not Cancer Driver No 49 0.153 84 12 0.143 0
INO80_ENST00000401393 INO80 Q9ULG1 Chromatin-remodeling ATPase INO80 chr15 GO:0071214 Compendium Yes 173 0.111 682 76 0.111 0
INSRR INSRR P14616 Insulin receptor-related protein chr1 GO:0071214 Not Cancer Driver No 262 0.202 228 37 0.162 0
INTS7 INTS7 Q9NVH2 Integrator complex subunit 7 chr1 GO:0071214 Not Cancer Driver No 106 0.11 88 17 0.193 0
IRF1 IRF1 P10914 Interferon regulatory factor 1 chr5 GO:0071214 Compendium Yes 49 0.151 228 31 0.136 2
ITGA2 ITGA2 P17301 Integrin alpha-2 chr5 GO:0071214 Not Cancer Driver No 166 0.141 26 0 0.0 0
ITGB6_ENST00000409872 ITGB6 P18564 Integrin beta-6 chr2 GO:0071214 Not Cancer Driver No 120 0.152 26 4 0.154 3
KCNJ2_ENST00000535240 KCNJ2 P63252 Inward rectifier potassium channel 2 chr17 GO:0071214 Not Cancer Driver No 103 0.241 49 11 0.224 12
KCNK18 KCNK18 Q7Z418 Potassium channel subfamily K member 18 chr10 GO:0071214 Not Cancer Driver No 103 0.268 7 0 0.0 0
KCNK4 KCNK4 Q9NYG8 Potassium channel subfamily K member 4 chr11 GO:0071214 Not Cancer Driver No 34 0.087 142 7 0.049 2
KDM1A_ENST00000356634 KDM1A O60341 Lysine-specific histone demethylase 1A chr1 GO:0071214 Not Cancer Driver No 67 0.079 291 28 0.096 3
KDM4D_ENST00000610872 KDM4D Q6B0I6 Lysine-specific demethylase 4D chr11 GO:0071214 Not Cancer Driver No 78 0.149 215 33 0.153 0
LIG4 LIG4 P49917 DNA ligase 4 chr13 GO:0071214 Not Cancer Driver No 134 0.147 63 10 0.159 2
LTBR LTBR P36941 Tumor necrosis factor receptor superfamily member 3 chr12 GO:0071214 Not Cancer Driver No 44 0.101 200 21 0.105 0
MAG_ENST00000537831 MAG P20916 Myelin-associated glycoprotein chr19 GO:0071214 Not Cancer Driver No 118 0.188 65 7 0.108 1
MAP2K4_ENST00000353533 MAP2K4 P45985 Dual specificity mitogen-activated protein kinase kinase 4 chr17 GO:0071214 Census, Compendium Yes 89 0.223 137 28 0.204 0
MAP3K1 MAP3K1 Q13233 Mitogen-activated protein kinase kinase kinase 1 chr5 GO:0071214 Census, Compendium Yes 184 0.122 820 62 0.076 3
MAP3K14 MAP3K14 Q99558 Mitogen-activated protein kinase kinase kinase 14 chr17 GO:0071214 Not Cancer Driver No 94 0.099 543 52 0.096 0
MAP3K20 MAP3K20 Q9NYL2 Mitogen-activated protein kinase kinase kinase 20 chr2 GO:0071214 Not Cancer Driver No 101 0.126 294 41 0.139 1
MAP3K2_ENST00000344908 MAP3K2 Q9Y2U5 Mitogen-activated protein kinase kinase kinase 2 chr2 GO:0071214 Not Cancer Driver No 75 0.121 313 47 0.15 0
MAPK13 MAPK13 O15264 Mitogen-activated protein kinase 13 chr6 GO:0071214 Not Cancer Driver No 51 0.14 50 15 0.3 0
MAPK14_ENST00000229794 MAPK14 Q16539 Mitogen-activated protein kinase 14 chr6 GO:0071214 Not Cancer Driver No 39 0.108 25 1 0.04 0
MAPK3 MAPK3 P27361 Mitogen-activated protein kinase 3 chr16 GO:0071214 Not Cancer Driver No 38 0.1 49 5 0.102 0
MAPK8_ENST00000374189 MAPK8 P45983 Mitogen-activated protein kinase 8 chr10 GO:0071214 Not Cancer Driver No 64 0.15 94 9 0.096 0
MC1R_ENST00000639847 MC1R Q01726 Melanocyte-stimulating hormone receptor chr16 GO:0071214 Not Cancer Driver No 39 0.123 0 0 0.0 5
MCOLN1 MCOLN1 Q9GZU1 Mucolipin-1 chr19 GO:0071214 Not Cancer Driver No 77 0.133 63 15 0.238 7
MDM2_ENST00000539479 MDM2 Q00987 E3 ubiquitin-protein ligase Mdm2 chr12 GO:0071214 Census, Compendium Yes 56 0.114 297 37 0.125 0
METTL3 METTL3 Q86U44 N6-adenosine-methyltransferase catalytic subunit chr14 GO:0071214 Not Cancer Driver No 74 0.128 274 29 0.106 0
MFAP4_ENST00000299610 MFAP4 P55083 Microfibril-associated glycoprotein 4 chr17 GO:0071214 Not Cancer Driver No 35 0.137 0 0 0.0 0
MME_ENST00000492661 MME P08473 Neprilysin chr3 GO:0071214 Not Cancer Driver No 189 0.252 40 17 0.425 4
MMP1 MMP1 P03956 Interstitial collagenase chr11 GO:0071214 Not Cancer Driver No 83 0.177 113 18 0.159 0
MMP2 MMP2 P08253 72 kDa type IV collagenase chr16 GO:0071214 Not Cancer Driver No 123 0.186 29 6 0.207 2
MMP3 MMP3 P08254 Stromelysin-1 chr11 GO:0071214 Not Cancer Driver No 99 0.208 66 14 0.212 0
MMP9 MMP9 P14780 Matrix metalloproteinase-9 chr20 GO:0071214 Not Cancer Driver No 129 0.182 124 26 0.21 0
MTPN MTPN P58546 Myotrophin chr7 GO:0071214 Not Cancer Driver No 11 0.093 11 3 0.273 0
MYC_ENST00000377970 MYC P01106 Myc proto-oncogene protein chr8 GO:0071214 Census, Compendium Yes 80 0.182 299 46 0.154 0
MYD88_ENST00000396334 MYD88 Q99836 Myeloid differentiation primary response protein MyD88 chr3 GO:0071214 Census, Compendium Yes 37 0.125 47 1 0.021 2
MYLK MYLK Q15746 Myosin light chain kinase, smooth muscle chr3 GO:0071214 Not Cancer Driver No 343 0.179 957 184 0.192 3
N4BP1 N4BP1 O75113 NEDD4-binding protein 1 chr16 GO:0071214 Not Cancer Driver No 108 0.121 432 58 0.134 0
NEDD4 NEDD4 P46934 E3 ubiquitin-protein ligase NEDD4 chr15 GO:0071214 Not Cancer Driver No 150 0.114 711 79 0.111 0
NET1 NET1 Q7Z628 Neuroepithelial cell-transforming gene 1 protein chr10 GO:0071214 Not Cancer Driver No 60 0.101 294 37 0.126 0
NEUROD2 NEUROD2 Q15784 Neurogenic differentiation factor 2 chr17 GO:0071214 Not Cancer Driver No 26 0.068 210 14 0.067 2
NFATC4_ENST00000250373 NFATC4 Q14934 Nuclear factor of activated T-cells, cytoplasmic 4 chr14 GO:0071214 Not Cancer Driver No 155 0.172 685 120 0.175 0
NFKB1_ENST00000505458 NFKB1 P19838 Nuclear factor NF-kappa-B p105 subunit chr4 GO:0071214 Not Cancer Driver No 104 0.107 344 38 0.11 0
NIPBL NIPBL Q6KC79 Nipped-B-like protein chr5 GO:0071214 Compendium Yes 353 0.126 1528 184 0.12 37
NOC2L NOC2L Q9Y3T9 Nucleolar complex protein 2 homolog chr1 GO:0071214 Not Cancer Driver No 77 0.103 281 31 0.11 0
NOX1 NOX1 Q9Y5S8 NADPH oxidase 1 chrX GO:0071214 Not Cancer Driver No 101 0.179 18 8 0.444 0
NPM1 NPM1 P06748 Nucleophosmin chr5 GO:0071214 Census, Compendium Yes 29 0.099 249 22 0.088 0
NSMCE3 NSMCE3 Q96MG7 Non-structural maintenance of chromosomes element 3 homolog chr15 GO:0071214 Not Cancer Driver No 33 0.109 128 7 0.055 2
NSMF NSMF Q6X4W1 NMDA receptor synaptonuclear signaling and neuronal migration factor chr9 GO:0071214 Not Cancer Driver No 46 0.087 287 19 0.066 2
NUCKS1 NUCKS1 Q9H1E3 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 chr1 GO:0071214 Not Cancer Driver No 30 0.123 243 30 0.123 0
OPN1SW OPN1SW P03999 Short-wave-sensitive opsin 1 chr7 GO:0071214 Not Cancer Driver No 65 0.187 20 1 0.05 4
OPN3 OPN3 Q9H1Y3 Opsin-3 chr1 GO:0071214 Not Cancer Driver No 39 0.097 6 1 0.167 0
OPN5 OPN5 Q6U736 Opsin-5 chr6 GO:0071214 Not Cancer Driver No 65 0.184 0 0 0.0 0
OXSR1 OXSR1 O95747 Serine/threonine-protein kinase OSR1 chr3 GO:0071214 Not Cancer Driver No 69 0.131 208 29 0.139 0
PALM PALM O75781 Paralemmin-1 chr19 GO:0071214 Not Cancer Driver No 50 0.129 381 50 0.131 0
PARP1 PARP1 P09874 Poly [ADP-ribose] polymerase 1 chr1 GO:0071214 Not Cancer Driver No 119 0.117 320 34 0.106 0
PBK_ENST00000301905 PBK Q96KB5 Lymphokine-activated killer T-cell-originated protein kinase chr8 GO:0071214 Not Cancer Driver No 23 0.071 92 6 0.065 0
PCK1 PCK1 P35558 Phosphoenolpyruvate carboxykinase, cytosolic [GTP] chr20 GO:0071214 Not Cancer Driver No 142 0.228 110 28 0.255 1
PCNA PCNA P12004 Proliferating cell nuclear antigen chr20 GO:0071214 Not Cancer Driver No 30 0.115 22 3 0.136 1
PDE2A PDE2A O00408 cGMP-dependent 3',5'-cyclic phosphodiesterase chr11 GO:0071214 Not Cancer Driver No 137 0.146 99 7 0.071 0
PIEZO1 PIEZO1 Q92508 Piezo-type mechanosensitive ion channel component 1 chr16 GO:0071214 Not Cancer Driver No 122 0.048 471 26 0.055 12
PIEZO2 PIEZO2 Q9H5I5 Piezo-type mechanosensitive ion channel component 2 chr18 GO:0071214 Not Cancer Driver No 198 0.072 603 19 0.032 8
PIK3CA PIK3CA P42336 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform chr3 GO:0071214 Census, Compendium Yes 1669 1.563 38 11 0.289 30
PIK3R1 PIK3R1 P27986 Phosphatidylinositol 3-kinase regulatory subunit alpha chr5 GO:0071214 Census, Compendium Yes 154 0.213 268 61 0.228 2
PKD1L3 PKD1L3 Q7Z443 Polycystic kidney disease protein 1-like 3 chr16 GO:0071214 Not Cancer Driver No 97 0.056 145 9 0.062 0
PKD2 PKD2 Q13563 Polycystin-2 chr4 GO:0071214 Not Cancer Driver No 113 0.117 375 35 0.093 10
PKD2L1 PKD2L1 Q9P0L9 Polycystic kidney disease 2-like 1 protein chr10 GO:0071214 Not Cancer Driver No 135 0.168 180 32 0.178 0
PLEC PLEC Q15149 Plectin chr8 GO:0071214 Not Cancer Driver No 677 0.145 2130 272 0.128 2
POLD1_ENST00000440232 POLD1 P28340 DNA polymerase delta catalytic subunit chr19 GO:0071214 Census, Compendium Yes 179 0.162 214 31 0.145 2
POLH POLH Q9Y253 DNA polymerase eta chr6 GO:0071214 Not Cancer Driver No 72 0.101 291 20 0.069 10
POLK POLK Q9UBT6 DNA polymerase kappa chr5 GO:0071214 Not Cancer Driver No 97 0.111 293 36 0.123 0
PPID PPID Q08752 Peptidyl-prolyl cis-trans isomerase D chr4 GO:0071214 Not Cancer Driver No 36 0.097 94 9 0.096 0
PRAP1 PRAP1 Q96NZ9 Proline-rich acidic protein 1 chr10 GO:0071214 Not Cancer Driver No 14 0.093 124 13 0.105 0
PRKCD_ENST00000330452 PRKCD Q05655 Protein kinase C delta type chr3 GO:0071214 Compendium Yes 79 0.117 43 9 0.209 0
PTAFR_ENST00000305392 PTAFR P25105 Platelet-activating factor receptor chr1 GO:0071214 Not Cancer Driver No 42 0.123 0 0 0.0 0
PTEN PTEN P60484 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN chr10 GO:0071214 Census, Compendium Yes 505 1.253 76 4 0.053 41
PTGER4 PTGER4 P35408 Prostaglandin E2 receptor EP4 subtype chr5 GO:0071214 Not Cancer Driver No 81 0.166 118 17 0.144 0
PTGS2 PTGS2 P35354 Prostaglandin G/H synthase 2 chr1 GO:0071214 Not Cancer Driver No 105 0.174 30 5 0.167 0
PTPRK_ENST00000368215 PTPRK Q15262 Receptor-type tyrosine-protein phosphatase kappa chr6 GO:0071214 Census, Compendium Yes 292 0.203 302 57 0.189 0
RAB11B RAB11B Q15907 Ras-related protein Rab-11B chr19 GO:0071214 Not Cancer Driver No 26 0.119 39 3 0.077 2
RAB11FIP5 RAB11FIP5 Q9BXF6 Rab11 family-interacting protein 5 chr2 GO:0071214 Not Cancer Driver No 83 0.127 533 70 0.131 0
RAD1 RAD1 O60671 Cell cycle checkpoint protein RAD1 chr5 GO:0071214 Not Cancer Driver No 29 0.103 4 1 0.25 0
RAD51AP1 RAD51AP1 Q96B01 RAD51-associated protein 1 chr12 GO:0071214 Not Cancer Driver No 46 0.131 335 43 0.128 0
RAD51_ENST00000267868 RAD51 Q06609 DNA repair protein RAD51 homolog 1 chr15 GO:0071214 Not Cancer Driver No 42 0.124 47 5 0.106 3
RAD9A RAD9A Q99638 Cell cycle checkpoint control protein RAD9A chr11 GO:0071214 Not Cancer Driver No 34 0.087 135 7 0.052 0
RAD9B RAD9B Q6WBX8 Cell cycle checkpoint control protein RAD9B chr12 GO:0071214 Not Cancer Driver No 46 0.108 40 6 0.15 0
RCSD1 RCSD1 Q6JBY9 CapZ-interacting protein chr1 GO:0071214 Not Cancer Driver No 70 0.168 416 70 0.168 0
REST REST Q13127 RE1-silencing transcription factor chr4 GO:0071214 Not Cancer Driver No 142 0.129 868 113 0.13 4
RGS9 RGS9 O75916 Regulator of G-protein signaling 9 chr17 GO:0071214 Not Cancer Driver No 138 0.205 240 65 0.271 1
RHBDD1 RHBDD1 Q8TEB9 Rhomboid-related protein 4 chr2 GO:0071214 Not Cancer Driver No 38 0.121 69 9 0.13 0
RHNO1 RHNO1 Q9BSD3 RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 chr12 GO:0071214 Not Cancer Driver No 26 0.109 193 21 0.109 0
RHO RHO P08100 Rhodopsin chr3 GO:0071214 Not Cancer Driver No 68 0.195 18 3 0.167 69
RHOB RHOB P62745 Rho-related GTP-binding protein RhoB chr2 GO:0071214 Not Cancer Driver No 52 0.265 19 2 0.105 0
RPE65 RPE65 Q16518 Retinoid isomerohydrolase chr1 GO:0071214 Not Cancer Driver No 109 0.205 10 1 0.1 44
RPL26 RPL26 P61254 60S ribosomal protein L26 chr17 GO:0071214 Not Cancer Driver No 16 0.11 114 13 0.114 0
RUVBL2 RUVBL2 Q9Y230 RuvB-like 2 chr19 GO:0071214 Not Cancer Driver No 62 0.134 100 13 0.13 0
SAG SAG P10523 S-arrestin chr2 GO:0071214 Not Cancer Driver No 70 0.173 102 11 0.108 0
SCN2A_ENST00000637266 SCN2A Q99250 Sodium channel protein type 2 subunit alpha chr2 GO:0071214 Not Cancer Driver No 502 0.25 435 133 0.306 65
SCNN1A_ENST00000228916 SCNN1A P37088 Amiloride-sensitive sodium channel subunit alpha chr12 GO:0071214 Not Cancer Driver No 73 0.109 146 21 0.144 5
SCNN1B SCNN1B P51168 Amiloride-sensitive sodium channel subunit beta chr16 GO:0071214 Not Cancer Driver No 90 0.141 62 4 0.065 13
SCNN1D SCNN1D P51172 Amiloride-sensitive sodium channel subunit delta chr1 GO:0071214 Not Cancer Driver No 56 0.07 210 9 0.043 0
SCNN1G SCNN1G P51170 Amiloride-sensitive sodium channel subunit gamma chr16 GO:0071214 Not Cancer Driver No 129 0.199 57 11 0.193 0
SDE2 SDE2 Q6IQ49 Replication stress response regulator SDE2 chr1 GO:0071214 Not Cancer Driver No 56 0.124 290 35 0.121 0
SFRP1 SFRP1 Q8N474 Secreted frizzled-related protein 1 chr8 GO:0071214 Not Cancer Driver No 40 0.127 39 7 0.179 0
SFRP2 SFRP2 Q96HF1 Secreted frizzled-related protein 2 chr4 GO:0071214 Not Cancer Driver No 47 0.159 1 0 0.0 0
SIPA1_ENST00000534313 SIPA1 Q96FS4 Signal-induced proliferation-associated protein 1 chr11 GO:0071214 Not Cancer Driver No 67 0.064 666 43 0.065 0
SIRT1 SIRT1 Q96EB6 NAD-dependent protein deacetylase sirtuin-1 chr10 GO:0071214 Not Cancer Driver No 70 0.094 435 31 0.071 0
SLC12A6_ENST00000558667 SLC12A6 Q9UHW9 Solute carrier family 12 member 6 chr15 GO:0071214 Not Cancer Driver No 168 0.146 280 46 0.164 0
SLC24A2 SLC24A2 Q9UI40 Sodium/potassium/calcium exchanger 2 chr9 GO:0071214 Not Cancer Driver No 120 0.182 144 24 0.167 0
SLC24A4 SLC24A4 Q8NFF2 Sodium/potassium/calcium exchanger 4 chr14 GO:0071214 Not Cancer Driver No 121 0.195 85 14 0.165 2
SLC2A1 SLC2A1 P11166 Solute carrier family 2, facilitated glucose transporter member 1 chr1 GO:0071214 Not Cancer Driver No 51 0.104 13 2 0.154 48
SLC38A2 SLC38A2 Q96QD8 Sodium-coupled neutral amino acid transporter 2 chr12 GO:0071214 Not Cancer Driver No 60 0.119 9 1 0.111 0
SLC38A3 SLC38A3 Q99624 Sodium-coupled neutral amino acid transporter 3 chr3 GO:0071214 Not Cancer Driver No 61 0.121 42 2 0.048 0
SLC4A11_ENST00000539553 SLC4A11 Q8NBS3 Solute carrier family 4 member 11 chr20 GO:0071214 Not Cancer Driver No 159 0.182 69 10 0.145 42
SLC9A1 SLC9A1 P19634 Sodium/hydrogen exchanger 1 chr1 GO:0071214 Not Cancer Driver No 89 0.109 251 29 0.116 1
SMPD1 SMPD1 P17405 Sphingomyelin phosphodiesterase chr11 GO:0071214 Not Cancer Driver No 93 0.147 51 4 0.078 111
SNAI2_ENST00000020945 SNAI2 O43623 Zinc finger protein SNAI2 chr8 GO:0071214 Not Cancer Driver No 52 0.194 52 9 0.173 0
SOX9 SOX9 P48436 Transcription factor SOX-9 chr17 GO:0071214 Compendium Yes 86 0.169 495 82 0.166 18
SPIDR SPIDR Q14159 DNA repair-scaffolding protein chr8 GO:0071214 Not Cancer Driver No 101 0.11 329 20 0.061 0
ST20_ENST00000562759 ST20 Q9HBF5 Suppressor of tumorigenicity 20 protein chr15 GO:0071214 Not Cancer Driver No 17 0.215 0 0 0.0 0
STK11 STK11 Q15831 Serine/threonine-protein kinase STK11 chr19 GO:0071214 Census, Compendium Yes 75 0.173 135 14 0.104 9
STK39 STK39 Q9UEW8 STE20/SPS1-related proline-alanine-rich protein kinase chr2 GO:0071214 Not Cancer Driver No 64 0.117 182 19 0.104 0
SWI5 SWI5 Q1ZZU3 DNA repair protein SWI5 homolog chr9 GO:0071214 Not Cancer Driver No 45 0.191 128 35 0.273 0
TAF1_ENST00000373790 TAF1 P21675 Transcription initiation factor TFIID subunit 1 chrX GO:0071214 Not Cancer Driver No 379 0.202 1152 219 0.19 5
TANK TANK Q92844 TRAF family member-associated NF-kappa-B activator chr2 GO:0071214 Not Cancer Driver No 42 0.099 302 26 0.086 0
TENT2_ENST00000428308 TENT2 Q6PIY7 Poly(A) RNA polymerase GLD2 chr5 GO:0071214 Not Cancer Driver No 65 0.134 75 15 0.2 0
TIMP1 TIMP1 P01033 Metalloproteinase inhibitor 1 chrX GO:0071214 Not Cancer Driver No 25 0.121 0 0 0.0 0
TLK2 TLK2 Q86UE8 Serine/threonine-protein kinase tousled-like 2 chr17 GO:0071214 Not Cancer Driver No 120 0.155 436 58 0.133 5
TLR3 TLR3 O15455 Toll-like receptor 3 chr4 GO:0071214 Not Cancer Driver No 123 0.136 0 0 0.0 1
TLR4_ENST00000355622 TLR4 O00206 Toll-like receptor 4 chr9 GO:0071214 Not Cancer Driver No 292 0.348 0 0 0.0 0
TLR5_ENST00000366881 TLR5 O60602 Toll-like receptor 5 chr1 GO:0071214 Not Cancer Driver No 148 0.172 16 3 0.188 0
TLR7 TLR7 Q9NYK1 Toll-like receptor 7 chrX GO:0071214 Not Cancer Driver No 182 0.173 14 1 0.071 1
TLR8_ENST00000218032 TLR8 Q9NR97 Toll-like receptor 8 chrX GO:0071214 Not Cancer Driver No 180 0.173 30 7 0.233 0
TMEM109 TMEM109 Q9BVC6 Transmembrane protein 109 chr11 GO:0071214 Not Cancer Driver No 39 0.16 7 0 0.0 0
TMEM150C TMEM150C B9EJG8 Transmembrane protein 150C chr4 GO:0071214 Not Cancer Driver No 38 0.153 0 0 0.0 0
TMEM161A TMEM161A Q9NX61 Transmembrane protein 161A chr19 GO:0071214 Not Cancer Driver No 49 0.102 22 8 0.364 0
TNFRSF10A TNFRSF10A O00220 Tumor necrosis factor receptor superfamily member 10A chr8 GO:0071214 Not Cancer Driver No 55 0.118 174 17 0.098 0
TNFRSF10B TNFRSF10B O14763 Tumor necrosis factor receptor superfamily member 10B chr8 GO:0071214 Not Cancer Driver No 44 0.1 190 19 0.1 0
TNFRSF1A TNFRSF1A P19438 Tumor necrosis factor receptor superfamily member 1A chr12 GO:0071214 Not Cancer Driver No 58 0.127 111 15 0.135 12
TNFRSF8 TNFRSF8 P28908 Tumor necrosis factor receptor superfamily member 8 chr1 GO:0071214 Not Cancer Driver No 95 0.16 286 35 0.122 0
TNFSF14 TNFSF14 O43557 Tumor necrosis factor ligand superfamily member 14 chr19 GO:0071214 Not Cancer Driver No 58 0.242 18 1 0.056 0
TNKS1BP1 TNKS1BP1 Q9C0C2 182 kDa tankyrase-1-binding protein chr11 GO:0071214 Not Cancer Driver No 221 0.128 1712 219 0.128 0
TP53BP1_ENST00000263801 TP53BP1 Q12888 TP53-binding protein 1 chr15 GO:0071214 Not Cancer Driver No 227 0.115 1632 190 0.116 0
TP53INP1 TP53INP1 Q96A56 Tumor protein p53-inducible nuclear protein 1 chr8 GO:0071214 Not Cancer Driver No 32 0.133 134 20 0.149 0
TP53_ENST00000445888 TP53 P04637 Cellular tumor antigen p53 chr17 GO:0071214 Census, Compendium Yes 2891 7.356 282 1466 5.199 83
TREX1_ENST00000625293 TREX1 Q9NSU2 Three-prime repair exonuclease 1 chr3 GO:0071214 Not Cancer Driver No 26 0.083 98 10 0.102 18
TRIAP1 TRIAP1 O43715 TP53-regulated inhibitor of apoptosis 1 chr12 GO:0071214 Not Cancer Driver No 9 0.118 20 1 0.05 0
TRPV1_ENST00000399756 TRPV1 Q8NER1 Transient receptor potential cation channel subfamily V member 1 chr17 GO:0071214 Not Cancer Driver No 93 0.111 155 18 0.116 0
TRPV4 TRPV4 Q9HBA0 Transient receptor potential cation channel subfamily V member 4 chr12 GO:0071214 Not Cancer Driver No 142 0.163 231 34 0.147 44
TSPO_ENST00000329563 TSPO P30536 Translocator protein chr22 GO:0071214 Not Cancer Driver No 5 0.03 1 0 0.0 0
TSPYL5 TSPYL5 Q86VY4 Testis-specific Y-encoded-like protein 5 chr8 GO:0071214 Not Cancer Driver No 92 0.221 257 61 0.237 0
USP28 USP28 Q96RU2 Ubiquitin carboxyl-terminal hydrolase 28 chr11 GO:0071214 Not Cancer Driver No 151 0.14 311 25 0.08 0
USP47 USP47 Q96K76 Ubiquitin carboxyl-terminal hydrolase 47 chr11 GO:0071214 Not Cancer Driver No 137 0.1 425 39 0.092 0
WNK3_ENST00000375159 WNK3 Q9BYP7 Serine/threonine-protein kinase WNK3 chrX GO:0071214 Not Cancer Driver No 281 0.156 1281 200 0.156 0
WNT11 WNT11 O96014 Protein Wnt-11 chr11 GO:0071214 Not Cancer Driver No 55 0.155 59 4 0.068 0
WRN WRN Q14191 Werner syndrome ATP-dependent helicase chr8 GO:0071214 Census, Compendium Yes 164 0.115 373 41 0.11 2
XPA XPA P23025 DNA repair protein complementing XP-A cells chr9 GO:0071214 Census Yes 27 0.099 121 13 0.107 5
XPC XPC Q01831 DNA repair protein complementing XP-C cells chr3 GO:0071214 Census, Compendium Yes 88 0.094 479 48 0.1 2
XRCC5_ENST00000392132 XRCC5 P13010 X-ray repair cross-complementing protein 5 chr2 GO:0071214 Not Cancer Driver No 87 0.119 118 11 0.093 0
XRCC6 XRCC6 P12956 X-ray repair cross-complementing protein 6 chr22 GO:0071214 Not Cancer Driver No 66 0.108 140 12 0.086 0
YAP1_ENST00000282441 YAP1 P46937 Transcriptional coactivator YAP1 chr11 GO:0071214 Not Cancer Driver No 51 0.101 489 49 0.1 0
YBX3 YBX3 P16989 Y-box-binding protein 3 chr12 GO:0071214 Not Cancer Driver No 49 0.132 359 47 0.131 0
YY1 YY1 P25490 Transcriptional repressor protein YY1 chr14 GO:0071214 Not Cancer Driver No 37 0.089 336 26 0.077 2
ZBTB1 ZBTB1 Q9Y2K1 Zinc finger and BTB domain-containing protein 1 chr14 GO:0071214 Not Cancer Driver No 70 0.098 271 27 0.1 0
ZFP36L1 ZFP36L1 Q07352 mRNA decay activator protein ZFP36L1 chr14 GO:0071214 Compendium Yes 57 0.169 212 30 0.142 0
ZMPSTE24 ZMPSTE24 O75844 CAAX prenyl protease 1 homolog chr1 GO:0071214 Not Cancer Driver No 67 0.141 23 0 0.0 3