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Total number of protein in "GO:0070851" GO term:  120

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
ADAM17 ADAM17 P78536 Disintegrin and metalloproteinase domain-containing protein 17 chr2 GO:0070851 Not Cancer Driver No 80 0.097 182 17 0.093 0
AGR2 AGR2 O95994 Anterior gradient protein 2 homolog chr7 GO:0070851 Not Cancer Driver No 23 0.131 20 2 0.1 0
APP APP P05067 Amyloid-beta precursor protein chr21 GO:0070851 Not Cancer Driver No 128 0.166 418 71 0.17 17
AREG AREG P15514 Amphiregulin chr4 GO:0070851 Not Cancer Driver No 28 0.111 149 20 0.134 0
ARF4 ARF4 P18085 ADP-ribosylation factor 4 chr3 GO:0070851 Not Cancer Driver No 17 0.094 0 0 0.0 0
ARTN_ENST00000372354 ARTN Q5T4W7 Artemin chr1 GO:0070851 Not Cancer Driver No 11 0.05 154 6 0.039 0
ATXN2_ENST00000550104 ATXN2 Q99700 Ataxin-2 chr12 GO:0070851 Not Cancer Driver No 146 0.111 1228 134 0.109 0
BTC BTC P35070 Probetacellulin chr4 GO:0070851 Not Cancer Driver No 29 0.163 12 5 0.417 0
CADM4 CADM4 Q8NFZ8 Cell adhesion molecule 4 chr19 GO:0070851 Not Cancer Driver No 48 0.124 94 9 0.096 0
CBLC_ENST00000647358 CBLC Q9ULV8 E3 ubiquitin-protein ligase CBL-C chr19 GO:0070851 Census Yes 60 0.127 128 21 0.164 0
CCDC88A_ENST00000642200 CCDC88A Q3V6T2 Girdin chr2 GO:0070851 Not Cancer Driver No 226 0.121 1481 173 0.117 0
CD2AP CD2AP Q9Y5K6 CD2-associated protein chr6 GO:0070851 Not Cancer Driver No 80 0.125 456 60 0.132 0
CD300LF_ENST00000326165 CD300LF Q8TDQ1 CMRF35-like molecule 1 chr17 GO:0070851 Not Cancer Driver No 36 0.124 88 11 0.125 0
CDH5 CDH5 P33151 Cadherin-5 chr16 GO:0070851 Not Cancer Driver No 144 0.184 305 55 0.18 0
CNOT9_ENST00000273064 CNOT9 Q92600 CCR4-NOT transcription complex subunit 9 chr2 GO:0070851 Compendium Yes 42 0.14 30 0 0.0 0
CNTF CNTF P26441 Ciliary neurotrophic factor chr11 GO:0070851 Not Cancer Driver No 41 0.205 34 5 0.147 0
CSF2 CSF2 P04141 Granulocyte-macrophage colony-stimulating factor chr5 GO:0070851 Not Cancer Driver No 11 0.076 34 3 0.088 0
CSF3 CSF3 P09919 Granulocyte colony-stimulating factor chr17 GO:0070851 Not Cancer Driver No 20 0.097 7 0 0.0 0
DAB2IP_ENST00000408936 DAB2IP Q5VWQ8 Disabled homolog 2-interacting protein chr9 GO:0070851 Not Cancer Driver No 131 0.11 681 68 0.1 0
ECM1_ENST00000369047 ECM1 Q16610 Extracellular matrix protein 1 chr1 GO:0070851 Not Cancer Driver No 91 0.169 219 28 0.128 1
EFEMP1_ENST00000355426 EFEMP1 Q12805 EGF-containing fibulin-like extracellular matrix protein 1 chr2 GO:0070851 Not Cancer Driver No 95 0.193 73 21 0.288 1
EGF EGF P01133 Pro-epidermal growth factor chr4 GO:0070851 Not Cancer Driver No 184 0.152 191 25 0.131 1
EPGN EPGN Q6UW88 Epigen chr4 GO:0070851 Not Cancer Driver No 16 0.104 0 0 0.0 0
ERAP1_ENST00000443439 ERAP1 Q9NZ08 Endoplasmic reticulum aminopeptidase 1 chr5 GO:0070851 Not Cancer Driver No 78 0.083 70 2 0.029 0
ERBB4 ERBB4 Q15303 Receptor tyrosine-protein kinase erbB-4 chr2 GO:0070851 Census, Compendium Yes 428 0.327 323 116 0.359 2
EREG EREG O14944 Proepiregulin chr4 GO:0070851 Not Cancer Driver No 26 0.154 10 3 0.3 0
ERN1 ERN1 O75460 Serine/threonine-protein kinase/endoribonuclease IRE1 chr17 GO:0070851 Not Cancer Driver No 125 0.128 250 28 0.112 0
ESM1 ESM1 Q9NQ30 Endothelial cell-specific molecule 1 chr5 GO:0070851 Not Cancer Driver No 44 0.239 37 11 0.297 0
FAM83B FAM83B Q5T0W9 Protein FAM83B chr6 GO:0070851 Not Cancer Driver No 314 0.311 684 219 0.32 0
FER FER P16591 Tyrosine-protein kinase Fer chr5 GO:0070851 Not Cancer Driver No 114 0.139 145 21 0.145 0
FGF10 FGF10 O15520 Fibroblast growth factor 10 chr5 GO:0070851 Not Cancer Driver No 56 0.269 34 11 0.324 2
FGF17 FGF17 O60258 Fibroblast growth factor 17 chr8 GO:0070851 Not Cancer Driver No 30 0.139 107 16 0.15 3
FGF18 FGF18 O76093 Fibroblast growth factor 18 chr5 GO:0070851 Not Cancer Driver No 40 0.193 57 14 0.246 0
FGF23 FGF23 Q9GZV9 Fibroblast growth factor 23 chr12 GO:0070851 Not Cancer Driver No 84 0.335 97 51 0.526 7
FGF7 FGF7 P21781 Fibroblast growth factor 7 chr15 GO:0070851 Not Cancer Driver No 38 0.196 22 4 0.182 0
FGF8_ENST00000344255 FGF8 P55075 Fibroblast growth factor 8 chr10 GO:0070851 Not Cancer Driver No 30 0.129 79 9 0.114 6
FYN FYN P06241 Tyrosine-protein kinase Fyn chr6 GO:0070851 Not Cancer Driver No 92 0.171 70 13 0.186 0
GATA3_ENST00000346208 GATA3 P23771 Trans-acting T-cell-specific transcription factor GATA-3 chr10 GO:0070851 Census, Compendium Yes 111 0.251 364 87 0.239 2
GDNF_ENST00000326524 GDNF P39905 Glial cell line-derived neurotrophic factor chr5 GO:0070851 Not Cancer Driver No 47 0.223 83 18 0.217 2
GLMN GLMN Q92990 Glomulin chr1 GO:0070851 Not Cancer Driver No 49 0.082 37 6 0.162 0
GRB2_ENST00000392564 GRB2 P62993 Growth factor receptor-bound protein 2 chr17 GO:0070851 Not Cancer Driver No 28 0.129 10 1 0.1 0
GREM1 GREM1 O60565 Gremlin-1 chr15 GO:0070851 Not Cancer Driver No 25 0.136 77 12 0.156 0
HBEGF HBEGF Q99075 Proheparin-binding EGF-like growth factor chr5 GO:0070851 Not Cancer Driver No 16 0.077 63 3 0.048 0
HIP1 HIP1 O00291 Huntingtin-interacting protein 1 chr7 GO:0070851 Census, Compendium Yes 137 0.132 510 70 0.137 0
IL10 IL10 P22301 Interleukin-10 chr1 GO:0070851 Not Cancer Driver No 19 0.107 23 1 0.043 0
IL11 IL11 P20809 Interleukin-11 chr19 GO:0070851 Not Cancer Driver No 19 0.095 69 8 0.116 0
IL12B IL12B P29460 Interleukin-12 subunit beta chr5 GO:0070851 Not Cancer Driver No 48 0.146 42 2 0.048 0
IL12RB1_ENST00000593993 IL12RB1 P42701 Interleukin-12 receptor subunit beta-1 chr19 GO:0070851 Not Cancer Driver No 108 0.163 207 38 0.184 1
IL1A IL1A P01583 Interleukin-1 alpha chr2 GO:0070851 Not Cancer Driver No 30 0.111 35 6 0.171 0
IL1B IL1B P01584 Interleukin-1 beta chr2 GO:0070851 Not Cancer Driver No 39 0.145 16 3 0.188 0
IL1F10_ENST00000341010 IL1F10 Q8WWZ1 Interleukin-1 family member 10 chr2 GO:0070851 Not Cancer Driver No 30 0.197 10 1 0.1 0
IL1R1 IL1R1 P14778 Interleukin-1 receptor type 1 chr2 GO:0070851 Not Cancer Driver No 77 0.135 59 8 0.136 0
IL1RAP_ENST00000447382 IL1RAP Q9NPH3 Interleukin-1 receptor accessory protein chr3 GO:0070851 Not Cancer Driver No 79 0.139 50 11 0.22 0
IL1RN_ENST00000409930 IL1RN P18510 Interleukin-1 receptor antagonist protein chr2 GO:0070851 Not Cancer Driver No 34 0.192 17 7 0.412 0
IL2 IL2 P60568 Interleukin-2 chr4 GO:0070851 Census Yes 24 0.157 6 1 0.167 0
IL21 IL21 Q9HBE4 Interleukin-21 chr4 GO:0070851 Not Cancer Driver No 34 0.21 70 18 0.257 1
IL23R IL23R Q5VWK5 Interleukin-23 receptor chr1 GO:0070851 Not Cancer Driver No 70 0.111 117 19 0.162 0
IL27RA IL27RA Q6UWB1 Interleukin-27 receptor subunit alpha chr19 GO:0070851 Not Cancer Driver No 91 0.143 167 23 0.138 0
IL3 IL3 P08700 Interleukin-3 chr5 GO:0070851 Not Cancer Driver No 25 0.164 22 3 0.136 0
IL36A IL36A Q9UHA7 Interleukin-36 alpha chr2 GO:0070851 Not Cancer Driver No 44 0.278 13 3 0.231 0
IL36B IL36B Q9NZH7 Interleukin-36 beta chr2 GO:0070851 Not Cancer Driver No 53 0.323 32 8 0.25 0
IL36G IL36G Q9NZH8 Interleukin-36 gamma chr2 GO:0070851 Not Cancer Driver No 35 0.207 23 5 0.217 0
IL36RN_ENST00000346807 IL36RN Q9UBH0 Interleukin-36 receptor antagonist protein chr2 GO:0070851 Not Cancer Driver No 34 0.219 7 4 0.571 4
IL37 IL37 Q9NZH6 Interleukin-37 chr2 GO:0070851 Not Cancer Driver No 56 0.257 71 13 0.183 1
IL4 IL4 P05112 Interleukin-4 chr5 GO:0070851 Not Cancer Driver No 18 0.118 0 0 0.0 0
IL5 IL5 P05113 Interleukin-5 chr5 GO:0070851 Not Cancer Driver No 13 0.097 0 0 0.0 0
IL6 IL6 P05231 Interleukin-6 chr7 GO:0070851 Not Cancer Driver No 35 0.165 58 7 0.121 0
IL6R IL6R P08887 Interleukin-6 receptor subunit alpha chr1 GO:0070851 Not Cancer Driver No 55 0.118 165 23 0.139 1
IL6ST_ENST00000336909 IL6ST P40189 Interleukin-6 receptor subunit beta chr5 GO:0070851 Census, Compendium Yes 102 0.111 315 40 0.127 2
IL7 IL7 P13232 Interleukin-7 chr8 GO:0070851 Not Cancer Driver No 29 0.164 19 4 0.211 0
IL9 IL9 P15248 Interleukin-9 chr5 GO:0070851 Not Cancer Driver No 12 0.083 4 0 0.0 0
IRAK4_ENST00000551736 IRAK4 Q9NWZ3 Interleukin-1 receptor-associated kinase 4 chr12 GO:0070851 Not Cancer Driver No 68 0.148 116 20 0.172 2
ITGA5 ITGA5 P08648 Integrin alpha-5 chr12 GO:0070851 Not Cancer Driver No 127 0.121 201 29 0.144 0
ITGB3 ITGB3 P05106 Integrin beta-3 chr17 GO:0070851 Not Cancer Driver No 124 0.157 66 5 0.076 30
JAK2 JAK2 O60674 Tyrosine-protein kinase JAK2 chr9 GO:0070851 Census, Compendium Yes 136 0.12 59 5 0.085 5
LINGO1 LINGO1 Q96FE5 Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 chr15 GO:0070851 Not Cancer Driver No 130 0.21 37 10 0.27 2
LYN LYN P07948 Tyrosine-protein kinase Lyn chr8 GO:0070851 Census Yes 95 0.186 84 12 0.143 0
MS4A1_ENST00000345732 MS4A1 P11836 B-lymphocyte antigen CD20 chr11 GO:0070851 Not Cancer Driver No 73 0.246 83 23 0.277 0
MYD88_ENST00000396334 MYD88 Q99836 Myeloid differentiation primary response protein MyD88 chr3 GO:0070851 Census, Compendium Yes 37 0.125 47 1 0.021 2
NCSTN NCSTN Q92542 Nicastrin chr1 GO:0070851 Not Cancer Driver No 94 0.133 72 11 0.153 1
NPTN NPTN Q9Y639 Neuroplastin chr15 GO:0070851 Not Cancer Driver No 47 0.118 118 9 0.076 0
NRTN NRTN Q99748 Neurturin chr19 GO:0070851 Not Cancer Driver No 7 0.036 26 0 0.0 0
PDCL3 PDCL3 Q9H2J4 Phosducin-like protein 3 chr2 GO:0070851 Not Cancer Driver No 48 0.201 73 13 0.178 0
PDGFA PDGFA P04085 Platelet-derived growth factor subunit A chr7 GO:0070851 Not Cancer Driver No 31 0.147 75 10 0.133 0
PDGFB PDGFB P01127 Platelet-derived growth factor subunit B chr22 GO:0070851 Census Yes 37 0.154 99 22 0.222 2
PDGFC PDGFC Q9NRA1 Platelet-derived growth factor C chr4 GO:0070851 Not Cancer Driver No 86 0.249 53 12 0.226 0
PDGFD PDGFD Q9GZP0 Platelet-derived growth factor D chr11 GO:0070851 Not Cancer Driver No 85 0.23 37 13 0.351 0
PDGFRA PDGFRA P16234 Platelet-derived growth factor receptor alpha chr4 GO:0070851 Census, Compendium Yes 290 0.266 173 45 0.26 2
PDGFRB PDGFRB P09619 Platelet-derived growth factor receptor beta chr5 GO:0070851 Census, Compendium Yes 164 0.148 231 44 0.19 7
PGF_ENST00000405431 PGF P49763 Placenta growth factor chr14 GO:0070851 Not Cancer Driver No 30 0.136 72 10 0.139 0
PIBF1 PIBF1 Q8WXW3 Progesterone-induced-blocking factor 1 chr13 GO:0070851 Not Cancer Driver No 83 0.11 419 45 0.107 2
PLSCR1 PLSCR1 O15162 Phospholipid scramblase 1 chr3 GO:0070851 Not Cancer Driver No 43 0.135 92 13 0.141 0
PSEN1 PSEN1 P49768 Presenilin-1 chr14 GO:0070851 Not Cancer Driver No 61 0.131 134 21 0.157 96
PSPN PSPN O60542 Persephin chr19 GO:0070851 Not Cancer Driver No 9 0.058 13 1 0.077 0
PTPRJ PTPRJ Q12913 Receptor-type tyrosine-protein phosphatase eta chr11 GO:0070851 Not Cancer Driver No 184 0.138 401 61 0.152 0
PYCARD PYCARD Q9ULZ3 Apoptosis-associated speck-like protein containing a CARD chr16 GO:0070851 Not Cancer Driver No 16 0.082 39 4 0.103 0
RNF126 RNF126 Q9BV68 E3 ubiquitin-protein ligase RNF126 chr19 GO:0070851 Not Cancer Driver No 33 0.106 182 22 0.121 0
RNF41_ENST00000615206 RNF41 Q9H4P4 E3 ubiquitin-protein ligase NRDP1 chr12 GO:0070851 Not Cancer Driver No 44 0.139 33 2 0.061 0
SDCBP_ENST00000260130 SDCBP O00560 Syntenin-1 chr8 GO:0070851 Not Cancer Driver No 39 0.131 17 2 0.118 0
SHC1_ENST00000368445 SHC1 P29353 SHC-transforming protein 1 chr1 GO:0070851 Not Cancer Driver No 84 0.144 397 58 0.146 0
SLC9A3R1 SLC9A3R1 O14745 Na(+)/H(+) exchange regulatory cofactor NHE-RF1 chr17 GO:0070851 Not Cancer Driver No 19 0.053 318 16 0.05 4
SNX1_ENST00000559844 SNX1 Q13596 Sorting nexin-1 chr15 GO:0070851 Not Cancer Driver No 61 0.117 214 25 0.117 0
SNX2 SNX2 O60749 Sorting nexin-2 chr5 GO:0070851 Not Cancer Driver No 45 0.087 218 18 0.083 0
SNX4 SNX4 O95219 Sorting nexin-4 chr3 GO:0070851 Not Cancer Driver No 31 0.069 101 5 0.05 0
SOCS5 SOCS5 O75159 Suppressor of cytokine signaling 5 chr2 GO:0070851 Not Cancer Driver No 84 0.157 297 46 0.155 0
SRC_ENST00000358208 SRC P12931 Proto-oncogene tyrosine-protein kinase Src chr20 GO:0070851 Census Yes 53 0.099 130 11 0.085 1
TGFA_ENST00000295400 TGFA P01135 Protransforming growth factor alpha chr2 GO:0070851 Not Cancer Driver No 20 0.125 0 0 0.0 0
TIMM50_ENST00000607714 TIMM50 Q3ZCQ8 Mitochondrial import inner membrane translocase subunit TIM50 chr19 GO:0070851 Not Cancer Driver No 39 0.11 75 7 0.093 0
TLR5_ENST00000366881 TLR5 O60602 Toll-like receptor 5 chr1 GO:0070851 Not Cancer Driver No 148 0.172 16 3 0.188 0
TLR9 TLR9 Q9NR96 Toll-like receptor 9 chr3 GO:0070851 Not Cancer Driver No 141 0.137 35 3 0.086 0
TNK2_ENST00000333602 TNK2 Q07912 Activated CDC42 kinase 1 chr3 GO:0070851 Not Cancer Driver No 137 0.132 593 81 0.137 0
TOLLIP TOLLIP Q9H0E2 Toll-interacting protein chr11 GO:0070851 Not Cancer Driver No 38 0.139 81 12 0.148 0
TRIP6 TRIP6 Q15654 Thyroid receptor-interacting protein 6 chr7 GO:0070851 Not Cancer Driver No 62 0.13 268 19 0.071 0
TSLP TSLP Q969D9 Thymic stromal lymphopoietin chr5 GO:0070851 Not Cancer Driver No 27 0.17 16 0 0.0 0
VAV2 VAV2 P52735 Guanine nucleotide exchange factor VAV2 chr9 GO:0070851 Not Cancer Driver No 127 0.145 135 17 0.126 0
VAV3 VAV3 Q9UKW4 Guanine nucleotide exchange factor VAV3 chr1 GO:0070851 Not Cancer Driver No 153 0.181 102 18 0.176 0
VEGFA_ENST00000523873 VEGFA P15692 Vascular endothelial growth factor A chr6 GO:0070851 Not Cancer Driver No 27 0.116 41 7 0.171 0
VEGFB VEGFB P49765 Vascular endothelial growth factor B chr11 GO:0070851 Not Cancer Driver No 25 0.121 125 22 0.176 0
VEGFC VEGFC P49767 Vascular endothelial growth factor C chr4 GO:0070851 Not Cancer Driver No 128 0.305 37 12 0.324 0
VEGFD VEGFD O43915 Vascular endothelial growth factor D chrX GO:0070851 Not Cancer Driver No 59 0.167 33 6 0.182 0