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Total number of protein in "GO:0062197" GO term:  138

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
ABL1_ENST00000318560 ABL1 P00519 Tyrosine-protein kinase ABL1 chr9 GO:0062197 Census, Compendium Yes 139 0.123 604 73 0.121 2
ADPRHL2 ADPRS Q9NX46 ADP-ribosylhydrolase ARH3 chr1 GO:0062197 Not Cancer Driver No 32 0.088 49 4 0.082 1
AGAP3_ENST00000622464 AGAP3 Q96P47 Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 chr7 GO:0062197 Not Cancer Driver No 116 0.133 404 55 0.136 0
AIF1 AIF1 P55008 Allograft inflammatory factor 1 chr6 GO:0062197 Not Cancer Driver No 14 0.095 61 6 0.098 0
AIFM1 AIFM1 O95831 Apoptosis-inducing factor 1, mitochondrial chrX GO:0062197 Not Cancer Driver No 88 0.144 166 22 0.133 11
AKR1B1 AKR1B1 P15121 Aldo-keto reductase family 1 member B1 chr7 GO:0062197 Not Cancer Driver No 52 0.165 19 1 0.053 0
AKR1C3 AKR1C3 P42330 Aldo-keto reductase family 1 member C3 chr10 GO:0062197 Not Cancer Driver No 49 0.152 11 1 0.091 0
AKT1_ENST00000349310 AKT1 P31749 RAC-alpha serine/threonine-protein kinase chr14 GO:0062197 Census, Compendium Yes 108 0.225 158 24 0.152 4
ANKZF1 ANKZF1 Q9H8Y5 Ankyrin repeat and zinc finger domain-containing protein 1 chr2 GO:0062197 Not Cancer Driver No 77 0.106 507 57 0.112 0
ANXA1_ENST00000257497 ANXA1 P04083 Annexin A1 chr9 GO:0062197 Not Cancer Driver No 59 0.171 61 12 0.197 0
APEX1_ENST00000555414 APEX1 P27695 DNA-(apurinic or apyrimidinic site) endonuclease chr14 GO:0062197 Not Cancer Driver No 34 0.107 103 14 0.136 0
AQP1 AQP1 P29972 Aquaporin-1 chr7 GO:0062197 Not Cancer Driver No 39 0.145 4 1 0.25 0
AQP5 AQP5 P55064 Aquaporin-5 chr12 GO:0062197 Not Cancer Driver No 31 0.117 21 2 0.095 5
ARG1_ENST00000368087 ARG1 P05089 Arginase-1 chr6 GO:0062197 Not Cancer Driver No 41 0.127 83 12 0.145 9
ARHGEF2 ARHGEF2 Q92974 Rho guanine nucleotide exchange factor 2 chr1 GO:0062197 Not Cancer Driver No 146 0.148 450 70 0.156 0
ATF4_ENST00000404241 ATF4 P18848 Cyclic AMP-dependent transcription factor ATF-4 chr22 GO:0062197 Not Cancer Driver No 53 0.151 259 38 0.147 0
ATG5_ENST00000343245 ATG5 Q9H1Y0 Autophagy protein 5 chr6 GO:0062197 Not Cancer Driver No 40 0.145 25 6 0.24 1
ATG7 ATG7 O95352 Ubiquitin-like modifier-activating enzyme ATG7 chr3 GO:0062197 Compendium Yes 77 0.11 53 8 0.151 6
ATM_ENST00000452508 ATM Q13315 Serine-protein kinase ATM chr11 GO:0062197 Census, Compendium Yes 469 0.153 225 39 0.173 41
AXL AXL P30530 Tyrosine-protein kinase receptor UFO chr19 GO:0062197 Not Cancer Driver No 168 0.188 341 64 0.188 0
BECN1_ENST00000590099 BECN1 Q14457 Beclin-1 chr17 GO:0062197 Not Cancer Driver No 45 0.1 190 19 0.1 0
BTK_ENST00000308731 BTK Q06187 Tyrosine-protein kinase BTK chrX GO:0062197 Census, Compendium Yes 147 0.223 114 27 0.237 110
CAB39 CAB39 Q9Y376 Calcium-binding protein 39 chr2 GO:0062197 Not Cancer Driver No 31 0.091 43 5 0.116 0
CAMKK2 CAMKK2 Q96RR4 Calcium/calmodulin-dependent protein kinase kinase 2 chr12 GO:0062197 Not Cancer Driver No 65 0.111 281 35 0.125 0
CAPN3 CAPN3 P20807 Calpain-3 chr15 GO:0062197 Not Cancer Driver No 111 0.135 168 11 0.065 52
CASP3 CASP3 P42574 Caspase-3 chr4 GO:0062197 Census Yes 32 0.116 62 5 0.081 0
CAV1 CAV1 Q03135 Caveolin-1 chr7 GO:0062197 Not Cancer Driver No 30 0.169 2 0 0.0 0
CD36_ENST00000309881 CD36 P16671 Platelet glycoprotein 4 chr7 GO:0062197 Not Cancer Driver No 75 0.159 12 3 0.25 3
CDK1 CDK1 P06493 Cyclin-dependent kinase 1 chr10 GO:0062197 Not Cancer Driver No 40 0.135 1 0 0.0 0
CHUK CHUK O15111 Inhibitor of nuclear factor kappa-B kinase subunit alpha chr10 GO:0062197 Not Cancer Driver No 74 0.099 116 9 0.078 0
CRYGD CRYGD P07320 Gamma-crystallin D chr2 GO:0062197 Not Cancer Driver No 28 0.161 0 0 0.0 6
CYP1B1 CYP1B1 Q16678 Cytochrome P450 1B1 chr2 GO:0062197 Not Cancer Driver No 61 0.112 31 3 0.097 40
DAPK1_ENST00000622514 DAPK1 P53355 Death-associated protein kinase 1 chr9 GO:0062197 Not Cancer Driver No 193 0.135 114 11 0.096 0
DDIT3_ENST00000623876 DDIT3 P35638 DNA damage-inducible transcript 3 protein chr12 GO:0062197 Census Yes 29 0.172 160 27 0.169 0
ECT2 ECT2 Q9H8V3 Protein ECT2 chr3 GO:0062197 Not Cancer Driver No 104 0.114 284 33 0.116 0
EDN1 EDN1 P05305 Endothelin-1 chr6 GO:0062197 Not Cancer Driver No 37 0.175 97 20 0.206 3
EGFR EGFR P00533 Epidermal growth factor receptor chr7 GO:0062197 Census, Compendium Yes 444 0.367 223 35 0.157 1
EIF2AK3 EIF2AK3 Q9NZJ5 Eukaryotic translation initiation factor 2-alpha kinase 3 chr2 GO:0062197 Not Cancer Driver No 149 0.134 410 51 0.124 1
EIF2S1 EIF2S1 P05198 Eukaryotic translation initiation factor 2 subunit 1 chr14 GO:0062197 Not Cancer Driver No 35 0.111 59 6 0.102 0
EPO EPO P01588 Erythropoietin chr7 GO:0062197 Not Cancer Driver No 27 0.14 9 1 0.111 1
ERN1 ERN1 O75460 Serine/threonine-protein kinase/endoribonuclease IRE1 chr17 GO:0062197 Not Cancer Driver No 125 0.128 250 28 0.112 0
ERRFI1 ERRFI1 Q9UJM3 ERBB receptor feedback inhibitor 1 chr1 GO:0062197 Not Cancer Driver No 55 0.119 297 37 0.125 0
EZH2_ENST00000460911 EZH2 Q15910 Histone-lysine N-methyltransferase EZH2 chr7 GO:0062197 Census, Compendium Yes 120 0.161 284 44 0.155 11
FABP1 FABP1 P07148 Fatty acid-binding protein, liver chr2 GO:0062197 Not Cancer Driver No 34 0.268 0 0 0.0 0
FAS FAS P25445 Tumor necrosis factor receptor superfamily member 6 chr10 GO:0062197 Census, Compendium Yes 55 0.164 62 18 0.29 22
FER FER P16591 Tyrosine-protein kinase Fer chr5 GO:0062197 Not Cancer Driver No 114 0.139 145 21 0.145 0
FOS FOS P01100 Protein c-Fos chr14 GO:0062197 Not Cancer Driver No 45 0.118 245 33 0.135 0
FOXO1 FOXO1 Q12778 Forkhead box protein O1 chr13 GO:0062197 Census, Compendium Yes 81 0.124 584 75 0.128 0
FXN FXN Q16595 Frataxin, mitochondrial chr9 GO:0062197 Not Cancer Driver No 16 0.076 73 0 0.0 8
GLRX2_ENST00000367439 GLRX2 Q9NS18 Glutaredoxin-2, mitochondrial chr1 GO:0062197 Not Cancer Driver No 12 0.073 10 1 0.1 0
HDAC2 HDAC2 Q92769 Histone deacetylase 2 chr6 GO:0062197 Not Cancer Driver No 46 0.094 145 14 0.097 0
HDAC6_ENST00000426196 HDAC6 Q9UBN7 Histone deacetylase 6 chrX GO:0062197 Not Cancer Driver No 178 0.147 409 59 0.144 0
HSF1 HSF1 Q00613 Heat shock factor protein 1 chr8 GO:0062197 Not Cancer Driver No 59 0.112 335 37 0.11 0
IL18BP_ENST00000337131 IL18BP O95998 Interleukin-18-binding protein chr11 GO:0062197 Not Cancer Driver No 16 0.082 50 6 0.12 0
IL6 IL6 P05231 Interleukin-6 chr7 GO:0062197 Not Cancer Driver No 35 0.165 58 7 0.121 0
IMPACT IMPACT Q9P2X3 Protein IMPACT chr18 GO:0062197 Not Cancer Driver No 49 0.153 84 12 0.143 0
JUN JUN P05412 Transcription factor Jun chr1 GO:0062197 Census Yes 35 0.106 281 25 0.089 0
KDM6B_ENST00000448097 KDM6B O15054 Lysine-specific demethylase 6B chr17 GO:0062197 Not Cancer Driver No 189 0.115 1278 142 0.111 2
KLF2 KLF2 Q9Y5W3 Krueppel-like factor 2 chr19 GO:0062197 Not Cancer Driver No 13 0.037 280 4 0.014 0
MAP1LC3A_ENST00000397709 MAP1LC3A Q9H492 Microtubule-associated proteins 1A/1B light chain 3A chr20 GO:0062197 Not Cancer Driver No 22 0.182 24 1 0.042 0
MAP3K5 MAP3K5 Q99683 Mitogen-activated protein kinase kinase kinase 5 chr6 GO:0062197 Not Cancer Driver No 197 0.143 242 29 0.12 0
MAPK13 MAPK13 O15264 Mitogen-activated protein kinase 13 chr6 GO:0062197 Not Cancer Driver No 51 0.14 50 15 0.3 0
MAPK1_ENST00000398822 MAPK1 P28482 Mitogen-activated protein kinase 1 chr22 GO:0062197 Census, Compendium Yes 62 0.172 2 0 0.0 7
MAPK3 MAPK3 P27361 Mitogen-activated protein kinase 3 chr16 GO:0062197 Not Cancer Driver No 38 0.1 49 5 0.102 0
MAPK7 MAPK7 Q13164 Mitogen-activated protein kinase 7 chr17 GO:0062197 Not Cancer Driver No 92 0.113 490 50 0.102 0
MAPK8_ENST00000374189 MAPK8 P45983 Mitogen-activated protein kinase 8 chr10 GO:0062197 Not Cancer Driver No 64 0.15 94 9 0.096 0
MAPK9 MAPK9 P45984 Mitogen-activated protein kinase 9 chr5 GO:0062197 Not Cancer Driver No 59 0.139 90 8 0.089 0
MAPT_ENST00000262410 MAPT P10636 Microtubule-associated protein tau chr17 GO:0062197 Not Cancer Driver No 128 0.169 750 126 0.168 18
MGST1_ENST00000396210 MGST1 P10620 Microsomal glutathione S-transferase 1 chr12 GO:0062197 Not Cancer Driver No 26 0.168 0 0 0.0 0
MMP2 MMP2 P08253 72 kDa type IV collagenase chr16 GO:0062197 Not Cancer Driver No 123 0.186 29 6 0.207 2
MMP9 MMP9 P14780 Matrix metalloproteinase-9 chr20 GO:0062197 Not Cancer Driver No 129 0.182 124 26 0.21 0
MPV17 MPV17 P39210 Protein Mpv17 chr2 GO:0062197 Not Cancer Driver No 21 0.119 0 0 0.0 16
MYC_ENST00000377970 MYC P01106 Myc proto-oncogene protein chr8 GO:0062197 Census, Compendium Yes 80 0.182 299 46 0.154 0
MYLK MYLK Q15746 Myosin light chain kinase, smooth muscle chr3 GO:0062197 Not Cancer Driver No 343 0.179 957 184 0.192 3
NCF1 NCF1 P14598 Neutrophil cytosol factor 1 chr7 GO:0062197 Not Cancer Driver No 37 0.095 181 12 0.066 1
NET1 NET1 Q7Z628 Neuroepithelial cell-transforming gene 1 protein chr10 GO:0062197 Not Cancer Driver No 60 0.101 294 37 0.126 0
NFE2L2 NFE2L2 Q16236 Nuclear factor erythroid 2-related factor 2 chr2 GO:0062197 Census, Compendium Yes 228 0.377 402 62 0.154 4
NME8_ENST00000440017 NME8 Q8N427 Thioredoxin domain-containing protein 3 chr7 GO:0062197 Not Cancer Driver No 178 0.303 87 44 0.506 0
NOX1 NOX1 Q9Y5S8 NADPH oxidase 1 chrX GO:0062197 Not Cancer Driver No 101 0.179 18 8 0.444 0
NQO1 NQO1 P15559 NAD(P)H dehydrogenase [quinone] 1 chr16 GO:0062197 Not Cancer Driver No 21 0.077 10 1 0.1 0
OSER1 OSER1 Q9NX31 Oxidative stress-responsive serine-rich protein 1 chr20 GO:0062197 Not Cancer Driver No 32 0.11 221 28 0.127 0
OXR1 OXR1 Q8N573 Oxidation resistance protein 1 chr8 GO:0062197 Not Cancer Driver No 126 0.144 544 76 0.14 0
OXSR1 OXSR1 O95747 Serine/threonine-protein kinase OSR1 chr3 GO:0062197 Not Cancer Driver No 69 0.131 208 29 0.139 0
PARK7_ENST00000377488 PARK7 Q99497 Parkinson disease protein 7 chr1 GO:0062197 Not Cancer Driver No 11 0.058 30 0 0.0 5
PAX2_ENST00000428433 PAX2 Q02962 Paired box protein Pax-2 chr10 GO:0062197 Not Cancer Driver No 62 0.149 296 48 0.162 23
PCNA PCNA P12004 Proliferating cell nuclear antigen chr20 GO:0062197 Not Cancer Driver No 30 0.115 22 3 0.136 1
PDGFD PDGFD Q9GZP0 Platelet-derived growth factor D chr11 GO:0062197 Not Cancer Driver No 85 0.23 37 13 0.351 0
PDGFRA PDGFRA P16234 Platelet-derived growth factor receptor alpha chr4 GO:0062197 Census, Compendium Yes 290 0.266 173 45 0.26 2
PDK2 PDK2 Q15119 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial chr17 GO:0062197 Not Cancer Driver No 45 0.111 35 4 0.114 0
PIK3CA PIK3CA P42336 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform chr3 GO:0062197 Census, Compendium Yes 1669 1.563 38 11 0.289 30
PKD2 PKD2 Q13563 Polycystin-2 chr4 GO:0062197 Not Cancer Driver No 113 0.117 375 35 0.093 10
PLEC PLEC Q15149 Plectin chr8 GO:0062197 Not Cancer Driver No 677 0.145 2130 272 0.128 2
PLEKHA1 PLEKHA1 Q9HB21 Pleckstrin homology domain-containing family A member 1 chr10 GO:0062197 Not Cancer Driver No 61 0.151 191 32 0.168 0
PPARGC1B PPARGC1B Q86YN6 Peroxisome proliferator-activated receptor gamma coactivator 1-beta chr5 GO:0062197 Not Cancer Driver No 125 0.122 845 99 0.117 0
PPIF PPIF P30405 Peptidyl-prolyl cis-trans isomerase F, mitochondrial chr10 GO:0062197 Not Cancer Driver No 19 0.092 43 4 0.093 0
PRDX3 PRDX3 P30048 Thioredoxin-dependent peroxide reductase, mitochondrial chr10 GO:0062197 Not Cancer Driver No 23 0.09 23 3 0.13 0
PRDX5 PRDX5 P30044 Peroxiredoxin-5, mitochondrial chr11 GO:0062197 Not Cancer Driver No 22 0.103 0 0 0.0 0
PRKAA1_ENST00000397128 PRKAA1 Q13131 5'-AMP-activated protein kinase catalytic subunit alpha-1 chr5 GO:0062197 Not Cancer Driver No 72 0.129 124 17 0.137 0
PRKCD_ENST00000330452 PRKCD Q05655 Protein kinase C delta type chr3 GO:0062197 Compendium Yes 79 0.117 43 9 0.209 0
PRKD1_ENST00000616995 PRKD1 Q15139 Serine/threonine-protein kinase D1 chr14 GO:0062197 Census Yes 201 0.22 189 33 0.175 2
PTGS2 PTGS2 P35354 Prostaglandin G/H synthase 2 chr1 GO:0062197 Not Cancer Driver No 105 0.174 30 5 0.167 0
PTPRK_ENST00000368215 PTPRK Q15262 Receptor-type tyrosine-protein phosphatase kappa chr6 GO:0062197 Census, Compendium Yes 292 0.203 302 57 0.189 0
PXN_ENST00000228307 PXN P49023 Paxillin chr12 GO:0062197 Not Cancer Driver No 62 0.105 341 24 0.07 0
RCSD1 RCSD1 Q6JBY9 CapZ-interacting protein chr1 GO:0062197 Not Cancer Driver No 70 0.168 416 70 0.168 0
RELA RELA Q04206 Transcription factor p65 chr11 GO:0062197 Compendium Yes 75 0.136 400 48 0.12 0
RHOB RHOB P62745 Rho-related GTP-binding protein RhoB chr2 GO:0062197 Not Cancer Driver No 52 0.265 19 2 0.105 0
RIPK1_ENST00000380409 RIPK1 Q13546 Receptor-interacting serine/threonine-protein kinase 1 chr6 GO:0062197 Compendium Yes 82 0.122 277 39 0.141 4
RIPK3 RIPK3 Q9Y572 Receptor-interacting serine/threonine-protein kinase 3 chr14 GO:0062197 Not Cancer Driver No 66 0.127 295 39 0.132 0
ROMO1_ENST00000397416 ROMO1 P60602 Reactive oxygen species modulator 1 chr20 GO:0062197 Not Cancer Driver No 9 0.114 0 0 0.0 0
RPS3_ENST00000527446 RPS3 P23396 40S ribosomal protein S3 chr11 GO:0062197 Not Cancer Driver No 22 0.091 48 4 0.083 0
SCN2A_ENST00000637266 SCN2A Q99250 Sodium channel protein type 2 subunit alpha chr2 GO:0062197 Not Cancer Driver No 502 0.25 435 133 0.306 65
SETX SETX Q7Z333 Probable helicase senataxin chr9 GO:0062197 Not Cancer Driver No 342 0.128 1240 156 0.126 20
SIRPA_ENST00000400068 SIRPA P78324 Tyrosine-protein phosphatase non-receptor type substrate 1 chr20 GO:0062197 Census, Compendium Yes 96 0.19 281 51 0.181 0
SIRT1 SIRT1 Q96EB6 NAD-dependent protein deacetylase sirtuin-1 chr10 GO:0062197 Not Cancer Driver No 70 0.094 435 31 0.071 0
SLC12A6_ENST00000558667 SLC12A6 Q9UHW9 Solute carrier family 12 member 6 chr15 GO:0062197 Not Cancer Driver No 168 0.146 280 46 0.164 0
SLC2A1 SLC2A1 P11166 Solute carrier family 2, facilitated glucose transporter member 1 chr1 GO:0062197 Not Cancer Driver No 51 0.104 13 2 0.154 48
SLC4A11_ENST00000539553 SLC4A11 Q8NBS3 Solute carrier family 4 member 11 chr20 GO:0062197 Not Cancer Driver No 159 0.182 69 10 0.145 42
SMPD3 SMPD3 Q9NY59 Sphingomyelin phosphodiesterase 3 chr16 GO:0062197 Not Cancer Driver No 92 0.14 224 29 0.129 0
SPHK1_ENST00000545180 SPHK1 Q9NYA1 Sphingosine kinase 1 chr17 GO:0062197 Not Cancer Driver No 47 0.122 25 2 0.08 0
SRC_ENST00000358208 SRC P12931 Proto-oncogene tyrosine-protein kinase Src chr20 GO:0062197 Census Yes 53 0.099 130 11 0.085 1
STAT6_ENST00000543873 STAT6 P42226 Signal transducer and activator of transcription 6 chr12 GO:0062197 Census, Compendium Yes 106 0.125 325 44 0.135 0
STK39 STK39 Q9UEW8 STE20/SPS1-related proline-alanine-rich protein kinase chr2 GO:0062197 Not Cancer Driver No 64 0.117 182 19 0.104 0
STOX1_ENST00000399169 STOX1 Q6ZVD7 Storkhead-box protein 1 chr10 GO:0062197 Not Cancer Driver No 121 0.122 659 83 0.126 2
TNFAIP3 TNFAIP3 P21580 Tumor necrosis factor alpha-induced protein 3 chr6 GO:0062197 Census, Compendium Yes 98 0.124 231 33 0.143 1
TP53INP1 TP53INP1 Q96A56 Tumor protein p53-inducible nuclear protein 1 chr8 GO:0062197 Not Cancer Driver No 32 0.133 134 20 0.149 0
TPM1_ENST00000403994 TPM1 P09493 Tropomyosin alpha-1 chain chr15 GO:0062197 Not Cancer Driver No 33 0.116 234 29 0.124 8
TREX1_ENST00000625293 TREX1 Q9NSU2 Three-prime repair exonuclease 1 chr3 GO:0062197 Not Cancer Driver No 26 0.083 98 10 0.102 18
TRPA1 TRPA1 O75762 Transient receptor potential cation channel subfamily A member 1 chr8 GO:0062197 Not Cancer Driver No 324 0.29 62 14 0.226 1
TRPM2_ENST00000397928 TRPM2 O94759 Transient receptor potential cation channel subfamily M member 2 chr21 GO:0062197 Not Cancer Driver No 286 0.19 266 44 0.165 0
TRPV4 TRPV4 Q9HBA0 Transient receptor potential cation channel subfamily V member 4 chr12 GO:0062197 Not Cancer Driver No 142 0.163 231 34 0.147 44
TSPO_ENST00000329563 TSPO P30536 Translocator protein chr22 GO:0062197 Not Cancer Driver No 5 0.03 1 0 0.0 0
UCP1 UCP1 P25874 Mitochondrial brown fat uncoupling protein 1 chr4 GO:0062197 Not Cancer Driver No 43 0.14 1 0 0.0 0
WNK3_ENST00000375159 WNK3 Q9BYP7 Serine/threonine-protein kinase WNK3 chrX GO:0062197 Not Cancer Driver No 281 0.156 1281 200 0.156 0
XRCC5_ENST00000392132 XRCC5 P13010 X-ray repair cross-complementing protein 5 chr2 GO:0062197 Not Cancer Driver No 87 0.119 118 11 0.093 0
YBX3 YBX3 P16989 Y-box-binding protein 3 chr12 GO:0062197 Not Cancer Driver No 49 0.132 359 47 0.131 0
ZFP36L1 ZFP36L1 Q07352 mRNA decay activator protein ZFP36L1 chr14 GO:0062197 Compendium Yes 57 0.169 212 30 0.142 0
ZNF277 ZNF277 Q9NRM2 Zinc finger protein 277 chr7 GO:0062197 Not Cancer Driver No 59 0.131 79 15 0.19 0
ZNF580_ENST00000545125 ZNF580 Q9UK33 Zinc finger protein 580 chr19 GO:0062197 Not Cancer Driver No 8 0.047 153 8 0.052 0