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Total number of protein in "GO:0061695" GO term:  118

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
ACVR1B_ENST00000257963 ACVR1B P36896 Activin receptor type-1B chr12 GO:0061695 Census Yes 114 0.226 0 0 0.0 0
ACVR1C ACVR1C Q8NER5 Activin receptor type-1C chr2 GO:0061695 Not Cancer Driver No 90 0.183 3 1 0.333 0
ACVR1_ENST00000434821 ACVR1 Q04771 Activin receptor type-1 chr2 GO:0061695 Census, Compendium Yes 78 0.153 21 8 0.381 8
ACVR2A_ENST00000404590 ACVR2A P27037 Activin receptor type-2A chr2 GO:0061695 Census, Compendium Yes 98 0.191 56 6 0.107 0
ACVR2B ACVR2B Q13705 Activin receptor type-2B chr3 GO:0061695 Not Cancer Driver No 83 0.162 70 14 0.2 2
AMHR2 AMHR2 Q16671 Anti-Muellerian hormone type-2 receptor chr12 GO:0061695 Not Cancer Driver No 77 0.134 117 7 0.06 8
ATG101 ATG101 Q9BSB4 Autophagy-related protein 101 chr12 GO:0061695 Not Cancer Driver No 21 0.096 5 0 0.0 0
ATG13_ENST00000359513 ATG13 O75143 Autophagy-related protein 13 chr11 GO:0061695 Not Cancer Driver No 55 0.106 205 27 0.132 0
BCCIP_ENST00000278100 BCCIP Q9P287 BRCA2 and CDKN1A-interacting protein chr10 GO:0061695 Not Cancer Driver No 35 0.111 99 16 0.162 0
BECN1_ENST00000590099 BECN1 Q14457 Beclin-1 chr17 GO:0061695 Not Cancer Driver No 45 0.1 190 19 0.1 0
CALM2 CALM2 P0DP24 Calmodulin-2 chr2 GO:0061695 Not Cancer Driver No 18 0.121 115 13 0.113 8
CCNA1 CCNA1 P78396 Cyclin-A1 chr13 GO:0061695 Not Cancer Driver No 112 0.241 82 21 0.256 0
CCNA2_ENST00000618014 CCNA2 P20248 Cyclin-A2 chr4 GO:0061695 Not Cancer Driver No 45 0.104 186 19 0.102 0
CCNB1 CCNB1 P14635 G2/mitotic-specific cyclin-B1 chr5 GO:0061695 Not Cancer Driver No 49 0.113 145 14 0.097 0
CCND1 CCND1 P24385 G1/S-specific cyclin-D1 chr11 GO:0061695 Census, Compendium Yes 55 0.186 31 25 0.806 0
CCND2 CCND2 P30279 G1/S-specific cyclin-D2 chr12 GO:0061695 Census, Compendium Yes 39 0.135 29 7 0.241 5
CCND3 CCND3 P30281 G1/S-specific cyclin-D3 chr6 GO:0061695 Census, Compendium Yes 29 0.099 46 8 0.174 0
CCNE1 CCNE1 P24864 G1/S-specific cyclin-E1 chr19 GO:0061695 Census Yes 63 0.154 142 26 0.183 0
CCNE2_ENST00000308108 CCNE2 O96020 G1/S-specific cyclin-E2 chr8 GO:0061695 Not Cancer Driver No 46 0.114 68 9 0.132 0
CCNH CCNH P51946 Cyclin-H chr5 GO:0061695 Not Cancer Driver No 40 0.124 28 4 0.143 0
CCNK CCNK O75909 Cyclin-K chr14 GO:0061695 Not Cancer Driver No 39 0.067 347 15 0.043 1
CCNO CCNO P22674 Cyclin-O chr5 GO:0061695 Not Cancer Driver No 18 0.051 101 3 0.03 2
CCNT1 CCNT1 O60563 Cyclin-T1 chr12 GO:0061695 Not Cancer Driver No 85 0.117 495 61 0.123 0
CCNT2 CCNT2 O60583 Cyclin-T2 chr2 GO:0061695 Not Cancer Driver No 76 0.104 471 52 0.11 0
CCNY CCNY Q8ND76 Cyclin-Y chr10 GO:0061695 Not Cancer Driver No 38 0.111 94 6 0.064 0
CDK1 CDK1 P06493 Cyclin-dependent kinase 1 chr10 GO:0061695 Not Cancer Driver No 40 0.135 1 0 0.0 0
CDK12 CDK12 Q9NYV4 Cyclin-dependent kinase 12 chr17 GO:0061695 Census, Compendium Yes 225 0.151 1202 160 0.133 0
CDK13 CDK13 Q14004 Cyclin-dependent kinase 13 chr7 GO:0061695 Not Cancer Driver No 155 0.103 1138 99 0.087 6
CDK14 CDK14 O94921 Cyclin-dependent kinase 14 chr7 GO:0061695 Not Cancer Driver No 93 0.198 154 21 0.136 0
CDK2 CDK2 P24941 Cyclin-dependent kinase 2 chr12 GO:0061695 Not Cancer Driver No 24 0.081 0 0 0.0 0
CDK4 CDK4 P11802 Cyclin-dependent kinase 4 chr12 GO:0061695 Census, Compendium Yes 52 0.172 52 5 0.096 3
CDK5 CDK5 Q00535 Cyclin-dependent kinase 5 chr7 GO:0061695 Not Cancer Driver No 48 0.164 5 1 0.2 0
CDK5R1 CDK5R1 Q15078 Cyclin-dependent kinase 5 activator 1 chr17 GO:0061695 Not Cancer Driver No 35 0.114 103 16 0.155 0
CDK5R2 CDK5R2 Q13319 Cyclin-dependent kinase 5 activator 2 chr2 GO:0061695 Not Cancer Driver No 14 0.038 204 5 0.025 0
CDK6 CDK6 Q00534 Cyclin-dependent kinase 6 chr7 GO:0061695 Census Yes 40 0.123 24 3 0.125 1
CDK7 CDK7 P50613 Cyclin-dependent kinase 7 chr5 GO:0061695 Not Cancer Driver No 41 0.118 38 5 0.132 0
CDK9 CDK9 P50750 Cyclin-dependent kinase 9 chr9 GO:0061695 Not Cancer Driver No 50 0.134 34 2 0.059 0
CDKN2D_ENST00000335766 CDKN2D P55273 Cyclin-dependent kinase 4 inhibitor D chr19 GO:0061695 Not Cancer Driver No 17 0.102 44 3 0.068 0
CHUK CHUK O15111 Inhibitor of nuclear factor kappa-B kinase subunit alpha chr10 GO:0061695 Not Cancer Driver No 74 0.099 116 9 0.078 0
CNTD2 CCNP Q9H8S5 Cyclin-P chr19 GO:0061695 Not Cancer Driver No 25 0.081 55 3 0.055 0
CRCP CRCP O75575 DNA-directed RNA polymerase III subunit RPC9 chr7 GO:0061695 Not Cancer Driver No 11 0.074 113 4 0.035 0
DAPK1_ENST00000622514 DAPK1 P53355 Death-associated protein kinase 1 chr9 GO:0061695 Not Cancer Driver No 193 0.135 114 11 0.096 0
ERC1 ERC1 Q8IUD2 ELKS/Rab6-interacting/CAST family member 1 chr12 GO:0061695 Census Yes 127 0.114 1013 119 0.117 0
ERN1 ERN1 O75460 Serine/threonine-protein kinase/endoribonuclease IRE1 chr17 GO:0061695 Not Cancer Driver No 125 0.128 250 28 0.112 0
IGF1R IGF1R P08069 Insulin-like growth factor 1 receptor chr15 GO:0061695 Not Cancer Driver No 183 0.134 265 37 0.14 6
IKBKB IKBKB O14920 Inhibitor of nuclear factor kappa-B kinase subunit beta chr8 GO:0061695 Census, Compendium Yes 106 0.14 211 31 0.147 1
IKBKG_ENST00000611071 IKBKG Q9Y6K9 NF-kappa-B essential modulator chrX GO:0061695 Not Cancer Driver No 6 0.014 301 6 0.02 22
INSR INSR P06213 Insulin receptor chr19 GO:0061695 Not Cancer Driver No 190 0.137 280 57 0.204 64
INSRR INSRR P14616 Insulin receptor-related protein chr1 GO:0061695 Not Cancer Driver No 262 0.202 228 37 0.162 0
IRS1 IRS1 P35568 Insulin receptor substrate 1 chr2 GO:0061695 Not Cancer Driver No 161 0.13 1072 133 0.124 2
LAS1L LAS1L Q9Y4W2 Ribosomal biogenesis protein LAS1L chrX GO:0061695 Not Cancer Driver No 100 0.136 279 49 0.176 0
MAD2L2 MAD2L2 Q9UI95 Mitotic spindle assembly checkpoint protein MAD2B chr1 GO:0061695 Not Cancer Driver No 22 0.104 0 0 0.0 1
MCM3_ENST00000229854 MCM3 P25205 DNA replication licensing factor MCM3 chr6 GO:0061695 Not Cancer Driver No 92 0.114 310 47 0.152 0
MNAT1 MNAT1 P51948 CDK-activating kinase assembly factor MAT1 chr14 GO:0061695 Not Cancer Driver No 23 0.074 64 2 0.031 0
PARD3 PARD3 Q8TEW0 Partitioning defective 3 homolog chr10 GO:0061695 Not Cancer Driver No 200 0.147 1144 170 0.149 2
PARD6A PARD6A Q9NPB6 Partitioning defective 6 homolog alpha chr16 GO:0061695 Not Cancer Driver No 25 0.072 177 13 0.073 0
PFKFB1 PFKFB1 P16118 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 chrX GO:0061695 Not Cancer Driver No 81 0.172 48 11 0.229 0
PFKL PFKL P17858 ATP-dependent 6-phosphofructokinase, liver type chr21 GO:0061695 Not Cancer Driver No 91 0.117 29 4 0.138 0
PFKM_ENST00000550924 PFKM P08237 ATP-dependent 6-phosphofructokinase, muscle type chr12 GO:0061695 Not Cancer Driver No 80 0.103 70 8 0.114 9
PFKP PFKP Q01813 ATP-dependent 6-phosphofructokinase, platelet type chr10 GO:0061695 Not Cancer Driver No 133 0.17 43 10 0.233 0
PHKA1 PHKA1 P46020 Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform chrX GO:0061695 Not Cancer Driver No 228 0.186 188 43 0.229 1
PHKA2 PHKA2 P46019 Phosphorylase b kinase regulatory subunit alpha, liver isoform chrX GO:0061695 Not Cancer Driver No 199 0.161 193 37 0.192 17
PHKB PHKB Q93100 Phosphorylase b kinase regulatory subunit beta chr16 GO:0061695 Not Cancer Driver No 147 0.134 98 9 0.092 1
PHKG1_ENST00000297373 PHKG1 Q16816 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform chr7 GO:0061695 Not Cancer Driver No 58 0.15 23 4 0.174 0
PHKG2 PHKG2 P15735 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform chr16 GO:0061695 Not Cancer Driver No 48 0.118 50 6 0.12 4
PIK3C3 PIK3C3 Q8NEB9 Phosphatidylinositol 3-kinase catalytic subunit type 3 chr18 GO:0061695 Not Cancer Driver No 127 0.143 191 34 0.178 0
PIK3CA PIK3CA P42336 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform chr3 GO:0061695 Census, Compendium Yes 1669 1.563 38 11 0.289 30
PIK3CB_ENST00000477593 PIK3CB P42338 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform chr3 GO:0061695 Census, Compendium Yes 150 0.14 42 4 0.095 0
PIK3CD PIK3CD O00329 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform chr1 GO:0061695 Not Cancer Driver No 140 0.134 60 13 0.217 1
PIK3CG PIK3CG P48736 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform chr7 GO:0061695 Not Cancer Driver No 318 0.289 121 39 0.322 0
PIK3R1 PIK3R1 P27986 Phosphatidylinositol 3-kinase regulatory subunit alpha chr5 GO:0061695 Census, Compendium Yes 154 0.213 268 61 0.228 2
PIK3R2_ENST00000617130 PIK3R2 O00459 Phosphatidylinositol 3-kinase regulatory subunit beta chr19 GO:0061695 Not Cancer Driver No 96 0.132 418 47 0.112 3
PIK3R4 PIK3R4 Q99570 Phosphoinositide 3-kinase regulatory subunit 4 chr3 GO:0061695 Not Cancer Driver No 193 0.142 315 45 0.143 0
PIK3R5 PIK3R5 Q8WYR1 Phosphoinositide 3-kinase regulatory subunit 5 chr17 GO:0061695 Not Cancer Driver No 143 0.163 316 55 0.174 1
PIK3R6_ENST00000614407 PIK3R6 Q5UE93 Phosphoinositide 3-kinase regulatory subunit 6 chr17 GO:0061695 Not Cancer Driver No 100 0.133 156 26 0.167 0
POLA1_ENST00000379059 POLA1 P09884 DNA polymerase alpha catalytic subunit chrX GO:0061695 Not Cancer Driver No 185 0.127 347 45 0.13 3
POLA2 POLA2 Q14181 DNA polymerase alpha subunit B chr11 GO:0061695 Not Cancer Driver No 63 0.105 102 16 0.157 0
POLD1_ENST00000440232 POLD1 P28340 DNA polymerase delta catalytic subunit chr19 GO:0061695 Census, Compendium Yes 179 0.162 214 31 0.145 2
POLD2_ENST00000452185 POLD2 P49005 DNA polymerase delta subunit 2 chr7 GO:0061695 Not Cancer Driver No 49 0.104 65 3 0.046 0
POLD3 POLD3 Q15054 DNA polymerase delta subunit 3 chr11 GO:0061695 Not Cancer Driver No 51 0.109 326 39 0.12 0
POLD4 POLD4 Q9HCU8 DNA polymerase delta subunit 4 chr11 GO:0061695 Not Cancer Driver No 8 0.075 50 3 0.06 0
POLG2 POLG2 Q9UHN1 DNA polymerase subunit gamma-2, mitochondrial chr17 GO:0061695 Not Cancer Driver No 64 0.132 46 4 0.087 3
POLG_ENST00000442287 POLG P54098 DNA polymerase subunit gamma-1 chr15 GO:0061695 Census Yes 139 0.112 421 42 0.1 73
POLRMT POLRMT O00411 DNA-directed RNA polymerase, mitochondrial chr19 GO:0061695 Not Cancer Driver No 188 0.153 253 31 0.123 0
PRIM1 PRIM1 P49642 DNA primase small subunit chr12 GO:0061695 Not Cancer Driver No 31 0.074 22 1 0.045 0
PRIM2 PRIM2 P49643 DNA primase large subunit chr6 GO:0061695 Not Cancer Driver No 180 0.354 69 57 0.826 0
PRKAA1_ENST00000397128 PRKAA1 Q13131 5'-AMP-activated protein kinase catalytic subunit alpha-1 chr5 GO:0061695 Not Cancer Driver No 72 0.129 124 17 0.137 0
PRKAA2 PRKAA2 P54646 5'-AMP-activated protein kinase catalytic subunit alpha-2 chr1 GO:0061695 Not Cancer Driver No 128 0.232 98 26 0.265 0
PRKAB1 PRKAB1 Q9Y478 5'-AMP-activated protein kinase subunit beta-1 chr12 GO:0061695 Not Cancer Driver No 39 0.144 124 13 0.105 0
PRKAB2 PRKAB2 O43741 5'-AMP-activated protein kinase subunit beta-2 chr1 GO:0061695 Not Cancer Driver No 31 0.114 110 12 0.109 0
PRKAG1_ENST00000548065 PRKAG1 P54619 5'-AMP-activated protein kinase subunit gamma-1 chr12 GO:0061695 Not Cancer Driver No 35 0.106 25 2 0.08 0
PRKAG2 PRKAG2 Q9UGJ0 5'-AMP-activated protein kinase subunit gamma-2 chr7 GO:0061695 Not Cancer Driver No 76 0.134 240 45 0.188 7
PRKAG3_ENST00000529249 PRKAG3 Q9UGI9 5'-AMP-activated protein kinase subunit gamma-3 chr2 GO:0061695 Not Cancer Driver No 74 0.151 144 25 0.174 0
PRKAR1A_ENST00000536854 PRKAR1A P10644 cAMP-dependent protein kinase type I-alpha regulatory subunit chr17 GO:0061695 Census, Compendium Yes 39 0.102 66 11 0.167 17
PRKAR2A PRKAR2A P13861 cAMP-dependent protein kinase type II-alpha regulatory subunit chr3 GO:0061695 Not Cancer Driver No 37 0.092 149 13 0.087 0
PRKCI PRKCI P41743 Protein kinase C iota type chr3 GO:0061695 Not Cancer Driver No 110 0.185 120 16 0.133 0
PRKDC PRKDC P78527 DNA-dependent protein kinase catalytic subunit chr8 GO:0061695 Not Cancer Driver No 538 0.13 421 61 0.145 2
PRPS1 PRPS1 P60891 Ribose-phosphate pyrophosphokinase 1 chrX GO:0061695 Not Cancer Driver No 50 0.157 0 0 0.0 14
PRPS1L1_ENST00000638645 PRPS1L1 P21108 Ribose-phosphate pyrophosphokinase 3 chr7 GO:0061695 Not Cancer Driver No 83 0.261 0 0 0.0 0
PRPS2_ENST00000380668 PRPS2 P11908 Ribose-phosphate pyrophosphokinase 2 chrX GO:0061695 Not Cancer Driver No 56 0.176 4 1 0.25 0
PRPSAP2 PRPSAP2 O60256 Phosphoribosyl pyrophosphate synthase-associated protein 2 chr17 GO:0061695 Not Cancer Driver No 54 0.146 19 3 0.158 0
PSG9 PSG9 Q00887 Pregnancy-specific beta-1-glycoprotein 9 chr19 GO:0061695 Not Cancer Driver No 125 0.293 40 8 0.2 0
PYCARD PYCARD Q9ULZ3 Apoptosis-associated speck-like protein containing a CARD chr16 GO:0061695 Not Cancer Driver No 16 0.082 39 4 0.103 0
PYDC1 PYDC1 Q8WXC3 Pyrin domain-containing protein 1 chr16 GO:0061695 Not Cancer Driver No 28 0.315 0 0 0.0 0
RB1CC1 RB1CC1 Q8TDY2 RB1-inducible coiled-coil protein 1 chr8 GO:0061695 Not Cancer Driver No 202 0.127 578 75 0.13 0
REV3L_ENST00000368802 REV3L O60673 DNA polymerase zeta catalytic subunit chr6 GO:0061695 Not Cancer Driver No 379 0.121 1665 211 0.127 0
SESN2 SESN2 P58004 Sestrin-2 chr1 GO:0061695 Not Cancer Driver No 74 0.154 147 26 0.177 0
SMCR8 SMCR8 Q8TEV9 Guanine nucleotide exchange protein SMCR8 chr17 GO:0061695 Not Cancer Driver No 107 0.114 357 38 0.106 0
TENT2_ENST00000428308 TENT2 Q6PIY7 Poly(A) RNA polymerase GLD2 chr5 GO:0061695 Not Cancer Driver No 65 0.134 75 15 0.2 0
TERT TERT O14746 Telomerase reverse transcriptase chr5 GO:0061695 Census Yes 110 0.097 212 16 0.075 31
TGFBR1_ENST00000374994 TGFBR1 P36897 TGF-beta receptor type-1 chr9 GO:0061695 Not Cancer Driver No 86 0.171 23 3 0.13 15
TGFBR2_ENST00000295754 TGFBR2 P37173 TGF-beta receptor type-2 chr3 GO:0061695 Census, Compendium Yes 106 0.187 60 16 0.267 25
TRIM40_ENST00000376724 TRIM40 Q6P9F5 E3 ubiquitin ligase TRIM40 chr6 GO:0061695 Not Cancer Driver No 44 0.171 84 12 0.143 0
ULK1 ULK1 O75385 Serine/threonine-protein kinase ULK1 chr12 GO:0061695 Not Cancer Driver No 142 0.135 588 77 0.131 0
VAC14 VAC14 Q08AM6 Protein VAC14 homolog chr16 GO:0061695 Not Cancer Driver No 97 0.124 116 19 0.164 3
XRCC5_ENST00000392132 XRCC5 P13010 X-ray repair cross-complementing protein 5 chr2 GO:0061695 Not Cancer Driver No 87 0.119 118 11 0.093 0
XRCC6 XRCC6 P12956 X-ray repair cross-complementing protein 6 chr22 GO:0061695 Not Cancer Driver No 66 0.108 140 12 0.086 0
ZNFX1_ENST00000371752 ZNFX1 Q9P2E3 NFX1-type zinc finger-containing protein 1 chr20 GO:0061695 Not Cancer Driver No 228 0.119 354 49 0.138 0