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Total number of protein in "GO:0051276" GO term:  133

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
ACD_ENST00000620761 ACD Q96AP0 Adrenocortical dysplasia protein homolog chr16 GO:0051276 Not Cancer Driver No 49 0.107 256 34 0.133 1
ACIN1 ACIN1 Q9UKV3 Apoptotic chromatin condensation inducer in the nucleus chr14 GO:0051276 Not Cancer Driver No 157 0.117 1294 155 0.12 0
AGO4 AGO4 Q9HCK5 Protein argonaute-4 chr1 GO:0051276 Not Cancer Driver No 100 0.116 183 24 0.131 0
APEX1_ENST00000555414 APEX1 P27695 DNA-(apurinic or apyrimidinic site) endonuclease chr14 GO:0051276 Not Cancer Driver No 34 0.107 103 14 0.136 0
ATM_ENST00000452508 ATM Q13315 Serine-protein kinase ATM chr11 GO:0051276 Census, Compendium Yes 469 0.153 225 39 0.173 41
AXIN2 AXIN2 Q9Y2T1 Axin-2 chr17 GO:0051276 Census, Compendium Yes 114 0.135 547 77 0.141 0
BAG6 BAG6 P46379 Large proline-rich protein BAG6 chr6 GO:0051276 Not Cancer Driver No 98 0.087 861 79 0.092 0
BLM BLM P54132 Bloom syndrome protein chr15 GO:0051276 Census Yes 153 0.108 667 70 0.105 8
BOD1 BOD1 Q96IK1 Biorientation of chromosomes in cell division protein 1 chr5 GO:0051276 Not Cancer Driver No 16 0.086 133 10 0.075 0
BRCA2_ENST00000544455 BRCA2 P51587 Breast cancer type 2 susceptibility protein chr13 GO:0051276 Census, Compendium Yes 457 0.134 1542 225 0.146 46
BUB1 BUB1 O43683 Mitotic checkpoint serine/threonine-protein kinase BUB1 chr2 GO:0051276 Not Cancer Driver No 139 0.128 466 64 0.137 0
BUB1B BUB1B O60566 Mitotic checkpoint serine/threonine-protein kinase BUB1 beta chr15 GO:0051276 Census Yes 96 0.091 480 35 0.073 7
C1orf146 SPO16 Q5VVC0 Protein SPO16 homolog chr1 GO:0051276 Not Cancer Driver No 24 0.133 0 0 0.0 0
CDCA8_ENST00000327331 CDCA8 Q53HL2 Borealin chr1 GO:0051276 Not Cancer Driver No 23 0.082 170 13 0.076 0
CENPI_ENST00000423383 CENPI Q92674 Centromere protein I chrX GO:0051276 Not Cancer Driver No 107 0.142 82 7 0.085 0
CENPO_ENST00000260662 CENPO Q9BU64 Centromere protein O chr2 GO:0051276 Not Cancer Driver No 23 0.077 54 5 0.093 0
CENPT_ENST00000440851 CENPT Q96BT3 Centromere protein T chr16 GO:0051276 Not Cancer Driver No 59 0.105 468 55 0.118 0
CENPV CENPV Q7Z7K6 Centromere protein V chr17 GO:0051276 Not Cancer Driver No 16 0.058 154 2 0.013 0
CENPW_ENST00000368328 CENPW Q5EE01 Centromere protein W chr6 GO:0051276 Not Cancer Driver No 9 0.102 5 1 0.2 0
DCLRE1A DCLRE1A Q6PJP8 DNA cross-link repair 1A protein chr10 GO:0051276 Not Cancer Driver No 92 0.088 514 45 0.088 0
DCLRE1B DCLRE1B Q9H816 5' exonuclease Apollo chr1 GO:0051276 Not Cancer Driver No 65 0.122 127 17 0.134 0
DCLRE1C DCLRE1C Q96SD1 Protein artemis chr10 GO:0051276 Not Cancer Driver No 76 0.11 277 26 0.094 3
DDX11 DDX11 Q96FC9 ATP-dependent DNA helicase DDX11 chr12 GO:0051276 Not Cancer Driver No 154 0.159 280 55 0.196 1
DFFB_ENST00000378209 DFFB O76075 DNA fragmentation factor subunit beta chr1 GO:0051276 Not Cancer Driver No 37 0.109 27 1 0.037 0
DHX36 DHX36 Q9H2U1 ATP-dependent DNA/RNA helicase DHX36 chr3 GO:0051276 Not Cancer Driver No 159 0.158 222 39 0.176 0
DHX9 DHX9 Q08211 ATP-dependent RNA helicase A chr1 GO:0051276 Compendium Yes 182 0.143 331 42 0.127 0
DNA2 DNA2 P51530 DNA replication ATP-dependent helicase/nuclease DNA2 chr10 GO:0051276 Not Cancer Driver No 120 0.113 52 8 0.154 3
EHMT2_ENST00000375537 EHMT2 Q96KQ7 Histone-lysine N-methyltransferase EHMT2 chr6 GO:0051276 Not Cancer Driver No 142 0.117 585 71 0.121 0
ERCC1_ENST00000589165 ERCC1 P07992 DNA excision repair protein ERCC-1 chr19 GO:0051276 Not Cancer Driver No 42 0.141 105 14 0.133 1
ERCC2 ERCC2 P18074 General transcription and DNA repair factor IIH helicase subunit XPD chr19 GO:0051276 Census, Compendium Yes 150 0.197 5 0 0.0 35
ERCC3 ERCC3 P19447 General transcription and DNA repair factor IIH helicase subunit XPB chr2 GO:0051276 Census, Compendium Yes 92 0.118 208 22 0.106 2
ERCC4 ERCC4 Q92889 DNA repair endonuclease XPF chr16 GO:0051276 Census Yes 120 0.131 225 27 0.12 15
ERN2 ERN2 Q76MJ5 Serine/threonine-protein kinase/endoribonuclease IRE2 chr16 GO:0051276 Not Cancer Driver No 192 0.207 213 45 0.211 0
FEN1 FEN1 P39748 Flap endonuclease 1 chr11 GO:0051276 Census Yes 35 0.092 111 11 0.099 0
GEM GEM P55040 GTP-binding protein GEM chr8 GO:0051276 Not Cancer Driver No 64 0.216 96 22 0.229 0
GPER1 GPER1 Q99527 G-protein coupled estrogen receptor 1 chr7 GO:0051276 Not Cancer Driver No 65 0.173 13 5 0.385 0
H1FNT H1-7 Q75WM6 Testis-specific H1 histone chr12 GO:0051276 Not Cancer Driver No 54 0.212 251 54 0.215 0
HMGA2_ENST00000403681 HMGA2 P52926 High mobility group protein HMGI-C chr12 GO:0051276 Census Yes 12 0.11 109 12 0.11 0
HMGB1_ENST00000405805 HMGB1 P09429 High mobility group protein B1 chr13 GO:0051276 Not Cancer Driver No 25 0.116 203 20 0.099 0
HMGB2 HMGB2 P26583 High mobility group protein B2 chr4 GO:0051276 Not Cancer Driver No 38 0.182 207 38 0.184 0
HNRNPA2B1 HNRNPA2B1 P22626 Heterogeneous nuclear ribonucleoproteins A2/B1 chr7 GO:0051276 Census, Compendium Yes 68 0.193 255 41 0.161 0
HORMAD1 HORMAD1 Q86X24 HORMA domain-containing protein 1 chr1 GO:0051276 Not Cancer Driver No 76 0.193 178 31 0.174 0
HORMAD2 HORMAD2 Q8N7B1 HORMA domain-containing protein 2 chr22 GO:0051276 Not Cancer Driver No 28 0.091 29 3 0.103 0
HSPA2_ENST00000247207 HSPA2 P54652 Heat shock-related 70 kDa protein 2 chr14 GO:0051276 Not Cancer Driver No 93 0.146 286 38 0.133 0
ITPA ITPA Q9BY32 Inosine triphosphate pyrophosphatase chr20 GO:0051276 Not Cancer Driver No 21 0.108 10 1 0.1 1
LIG4 LIG4 P49917 DNA ligase 4 chr13 GO:0051276 Not Cancer Driver No 134 0.147 63 10 0.159 2
MAJIN_ENST00000530444 MAJIN Q3KP22 Membrane-anchored junction protein chr11 GO:0051276 Not Cancer Driver No 17 0.097 143 15 0.105 0
MEIKIN MEIKIN A0A087WXM9 Meiosis-specific kinetochore protein chr5 GO:0051276 Not Cancer Driver No 2 0.005 221 1 0.005 0
MEIOC MEIOC A2RUB1 Meiosis-specific coiled-coil domain-containing protein MEIOC chr17 GO:0051276 Not Cancer Driver No 92 0.097 529 54 0.102 0
MLH1 MLH1 P40692 DNA mismatch repair protein Mlh1 chr3 GO:0051276 Census Yes 92 0.122 208 22 0.106 85
MLH3_ENST00000556740 MLH3 Q9UHC1 DNA mismatch repair protein Mlh3 chr14 GO:0051276 Not Cancer Driver No 154 0.106 593 60 0.101 9
MSH2 MSH2 P43246 DNA mismatch repair protein Msh2 chr2 GO:0051276 Census Yes 92 0.099 37 4 0.108 70
MSH3 MSH3 P20585 DNA mismatch repair protein Msh3 chr5 GO:0051276 Not Cancer Driver No 100 0.088 211 20 0.095 0
MSH6 MSH6 P52701 DNA mismatch repair protein Msh6 chr2 GO:0051276 Census Yes 154 0.113 386 41 0.106 6
MYC_ENST00000377970 MYC P01106 Myc proto-oncogene protein chr8 GO:0051276 Census, Compendium Yes 80 0.182 299 46 0.154 0
NAA50 NAA50 Q9GZZ1 N-alpha-acetyltransferase 50 chr3 GO:0051276 Not Cancer Driver No 14 0.083 14 1 0.071 0
NBN NBN O60934 Nibrin chr8 GO:0051276 Census Yes 90 0.119 417 54 0.129 1
NCAPD2 NCAPD2 Q15021 Condensin complex subunit 1 chr12 GO:0051276 Not Cancer Driver No 124 0.089 345 35 0.101 0
NCAPD3 NCAPD3 P42695 Condensin-2 complex subunit D3 chr11 GO:0051276 Not Cancer Driver No 193 0.129 304 42 0.138 1
NCAPH NCAPH Q15003 Condensin complex subunit 2 chr2 GO:0051276 Not Cancer Driver No 97 0.131 465 60 0.129 1
NCAPH2_ENST00000420993 NCAPH2 Q6IBW4 Condensin-2 complex subunit H2 chr22 GO:0051276 Not Cancer Driver No 67 0.111 335 39 0.116 0
NSMCE2_ENST00000522563 NSMCE2 Q96MF7 E3 SUMO-protein ligase NSE2 chr8 GO:0051276 Not Cancer Driver No 30 0.121 119 12 0.101 0
NUP107 NUP107 P57740 Nuclear pore complex protein Nup107 chr12 GO:0051276 Not Cancer Driver No 127 0.137 183 26 0.142 5
P3H4_ENST00000393928 P3H4 Q92791 Endoplasmic reticulum protein SC65 chr17 GO:0051276 Not Cancer Driver No 46 0.105 82 9 0.11 0
PCID2_ENST00000375479 PCID2 Q5JVF3 PCI domain-containing protein 2 chr13 GO:0051276 Not Cancer Driver No 46 0.115 13 5 0.385 0
PCNA PCNA P12004 Proliferating cell nuclear antigen chr20 GO:0051276 Not Cancer Driver No 30 0.115 22 3 0.136 1
PELO PELO Q9BRX2 Protein pelota homolog chr5 GO:0051276 Not Cancer Driver No 38 0.099 67 10 0.149 0
PLK1 PLK1 P53350 Serine/threonine-protein kinase PLK1 chr16 GO:0051276 Not Cancer Driver No 87 0.144 119 13 0.109 0
POT1 POT1 Q9NUX5 Protection of telomeres protein 1 chr7 GO:0051276 Census, Compendium Yes 113 0.178 31 6 0.194 9
PPP2R1A PPP2R1A P30153 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform chr19 GO:0051276 Census, Compendium Yes 179 0.304 0 0 0.0 4
PTTG1_ENST00000520452 PTTG1 O95997 Securin chr5 GO:0051276 Not Cancer Driver No 17 0.084 141 6 0.043 0
RAD21 RAD21 O60216 Double-strand-break repair protein rad21 homolog chr8 GO:0051276 Census, Compendium Yes 115 0.182 421 74 0.176 3
RAD21L1 RAD21L1 Q9H4I0 Double-strand-break repair protein rad21-like protein 1 chr20 GO:0051276 Not Cancer Driver No 37 0.067 186 5 0.027 0
RAD50 RAD50 Q92878 DNA repair protein RAD50 chr5 GO:0051276 Not Cancer Driver No 157 0.12 730 84 0.115 0
RAD51C RAD51C O43502 DNA repair protein RAD51 homolog 3 chr17 GO:0051276 Not Cancer Driver No 47 0.125 18 2 0.111 6
RAD51D_ENST00000394589 RAD51D O75771 DNA repair protein RAD51 homolog 4 chr17 GO:0051276 Not Cancer Driver No 34 0.104 49 10 0.204 0
RAD51_ENST00000267868 RAD51 Q06609 DNA repair protein RAD51 homolog 1 chr15 GO:0051276 Not Cancer Driver No 42 0.124 47 5 0.106 3
REC8_ENST00000611366 REC8 O95072 Meiotic recombination protein REC8 homolog chr14 GO:0051276 Not Cancer Driver No 60 0.11 244 26 0.107 0
RECQL4 RECQL4 O94761 ATP-dependent DNA helicase Q4 chr8 GO:0051276 Census, Compendium Yes 138 0.114 608 71 0.117 1
RFWD3 RFWD3 Q6PCD5 E3 ubiquitin-protein ligase RFWD3 chr16 GO:0051276 Census Yes 68 0.088 318 30 0.094 1
RIF1 RIF1 Q5UIP0 Telomere-associated protein RIF1 chr2 GO:0051276 Not Cancer Driver No 287 0.116 1355 164 0.121 0
RMI2 RMI2 Q96E14 RecQ-mediated genome instability protein 2 chr16 GO:0051276 Census Yes 12 0.082 86 5 0.058 0
RTEL1_ENST00000370018 RTEL1 Q9NZ71 Regulator of telomere elongation helicase 1 chr20 GO:0051276 Not Cancer Driver No 144 0.118 474 64 0.135 14
SELENOF_ENST00000616787 SELENOF O60613 Selenoprotein F chr1 GO:0051276 Not Cancer Driver No 7 0.042 0 0 0.0 0
SFPQ SFPQ P23246 Splicing factor, proline- and glutamine-rich chr1 GO:0051276 Census Yes 59 0.083 595 48 0.081 0
SGO1 SGO1 Q5FBB7 Shugoshin 1 chr3 GO:0051276 Not Cancer Driver No 57 0.102 360 39 0.108 1
SGO2 SGO2 Q562F6 Shugoshin 2 chr2 GO:0051276 Not Cancer Driver No 164 0.13 1025 134 0.131 0
SLX1B SLX1B Q9BQ83 Structure-specific endonuclease subunit SLX1 chr16 GO:0051276 Not Cancer Driver No 3 0.011 80 1 0.013 0
SLX4 SLX4 Q8IY92 Structure-specific endonuclease subunit SLX4 chr16 GO:0051276 Not Cancer Driver No 271 0.148 1573 232 0.147 0
SMC2 SMC2 O95347 Structural maintenance of chromosomes protein 2 chr9 GO:0051276 Not Cancer Driver No 145 0.121 573 88 0.154 0
SMC4_ENST00000344722 SMC4 Q9NTJ3 Structural maintenance of chromosomes protein 4 chr3 GO:0051276 Not Cancer Driver No 175 0.136 539 55 0.102 0
SMC5 SMC5 Q8IY18 Structural maintenance of chromosomes protein 5 chr9 GO:0051276 Not Cancer Driver No 126 0.114 378 43 0.114 0
SMC6_ENST00000351948 SMC6 Q96SB8 Structural maintenance of chromosomes protein 6 chr2 GO:0051276 Not Cancer Driver No 128 0.117 458 57 0.124 0
SPO11 SPO11 Q9Y5K1 Meiotic recombination protein SPO11 chr20 GO:0051276 Not Cancer Driver No 59 0.149 26 5 0.192 0
SRPK1 SRPK1 Q96SB4 SRSF protein kinase 1 chr6 GO:0051276 Not Cancer Driver No 73 0.111 329 32 0.097 0
STAG3_ENST00000426455 STAG3 Q9UJ98 Cohesin subunit SA-3 chr7 GO:0051276 Not Cancer Driver No 153 0.125 388 59 0.152 0
SYCE1L SYCE1L A8MT33 Synaptonemal complex central element protein 1-like chr16 GO:0051276 Not Cancer Driver No 19 0.079 170 16 0.094 0
SYCE1_ENST00000343131 SYCE1 Q8N0S2 Synaptonemal complex central element protein 1 chr10 GO:0051276 Not Cancer Driver No 70 0.199 251 50 0.199 0
SYCE2 SYCE2 Q6PIF2 Synaptonemal complex central element protein 2 chr19 GO:0051276 Not Cancer Driver No 27 0.124 148 15 0.101 0
SYCE3 SYCE3 A1L190 Synaptonemal complex central element protein 3 chr22 GO:0051276 Not Cancer Driver No 8 0.091 40 2 0.05 0
SYCP1_ENST00000618516 SYCP1 Q15431 Synaptonemal complex protein 1 chr1 GO:0051276 Not Cancer Driver No 207 0.212 602 124 0.206 0
SYCP2_ENST00000371001 SYCP2 Q9BX26 Synaptonemal complex protein 2 chr20 GO:0051276 Not Cancer Driver No 247 0.161 761 121 0.159 0
TCF7L2_ENST00000355995 TCF7L2 Q9NQB0 Transcription factor 7-like 2 chr10 GO:0051276 Census, Compendium Yes 122 0.197 516 93 0.18 0
TEP1 TEP1 Q99973 Telomerase protein component 1 chr14 GO:0051276 Not Cancer Driver No 332 0.126 396 67 0.169 0
TERB1_ENST00000558713 TERB1 Q8NA31 Telomere repeats-binding bouquet formation protein 1 chr16 GO:0051276 Not Cancer Driver No 33 0.045 201 14 0.07 0
TERB2 TERB2 Q8NHR7 Telomere repeats-binding bouquet formation protein 2 chr15 GO:0051276 Not Cancer Driver No 38 0.173 35 5 0.143 0
TERF1 TERF1 P54274 Telomeric repeat-binding factor 1 chr8 GO:0051276 Not Cancer Driver No 63 0.144 220 34 0.155 0
TERF2 TERF2 Q15554 Telomeric repeat-binding factor 2 chr16 GO:0051276 Not Cancer Driver No 33 0.061 361 20 0.055 0
TERF2IP TERF2IP Q9NYB0 Telomeric repeat-binding factor 2-interacting protein 1 chr16 GO:0051276 Not Cancer Driver No 28 0.07 310 16 0.052 0
TEX11_ENST00000344304 TEX11 Q8IYF3 Testis-expressed protein 11 chrX GO:0051276 Not Cancer Driver No 139 0.148 30 3 0.1 2
TEX12 TEX12 Q9BXU0 Testis-expressed protein 12 chr11 GO:0051276 Not Cancer Driver No 10 0.081 35 3 0.086 0
TEX15_ENST00000256246 TEX15 Q9BXT5 Testis-expressed protein 15 chr8 GO:0051276 Not Cancer Driver No 479 0.172 1258 223 0.177 0
TFIP11_ENST00000407148 TFIP11 Q9UBB9 Tuftelin-interacting protein 11 chr22 GO:0051276 Not Cancer Driver No 87 0.104 331 39 0.118 0
TINF2 TINF2 Q9BSI4 TERF1-interacting nuclear factor 2 chr14 GO:0051276 Not Cancer Driver No 38 0.084 190 17 0.089 4
TOP1 TOP1 P11387 DNA topoisomerase 1 chr20 GO:0051276 Census, Compendium Yes 93 0.122 391 53 0.136 0
TOP1MT TOP1MT Q969P6 DNA topoisomerase I, mitochondrial chr8 GO:0051276 Not Cancer Driver No 102 0.17 171 32 0.187 0
TOP2A TOP2A P11388 DNA topoisomerase 2-alpha chr17 GO:0051276 Compendium Yes 150 0.098 508 59 0.116 0
TOP2B TOP2B Q02880 DNA topoisomerase 2-beta chr3 GO:0051276 Not Cancer Driver No 154 0.095 543 46 0.085 0
TOP3A TOP3A Q13472 DNA topoisomerase 3-alpha chr17 GO:0051276 Not Cancer Driver No 103 0.103 293 31 0.106 2
TOP3B_ENST00000357179 TOP3B O95985 DNA topoisomerase 3-beta-1 chr22 GO:0051276 Not Cancer Driver No 102 0.118 151 17 0.113 0
TPRKB_ENST00000272424 TPRKB Q9Y3C4 EKC/KEOPS complex subunit TPRKB chr2 GO:0051276 Not Cancer Driver No 20 0.114 0 0 0.0 2
TRIP13 TRIP13 Q15645 Pachytene checkpoint protein 2 homolog chr5 GO:0051276 Not Cancer Driver No 62 0.144 30 6 0.2 1
TSSK6 TSSK6 Q9BXA6 Testis-specific serine/threonine-protein kinase 6 chr19 GO:0051276 Not Cancer Driver No 47 0.172 0 0 0.0 0
UBE2B UBE2B P63146 Ubiquitin-conjugating enzyme E2 B chr5 GO:0051276 Not Cancer Driver No 13 0.086 68 6 0.088 0
UPF1 UPF1 Q92900 Regulator of nonsense transcripts 1 chr19 GO:0051276 Not Cancer Driver No 146 0.129 329 36 0.109 0
WRAP53 WRAP53 Q9BUR4 Telomerase Cajal body protein 1 chr17 GO:0051276 Not Cancer Driver No 66 0.12 232 29 0.125 4
WRN WRN Q14191 Werner syndrome ATP-dependent helicase chr8 GO:0051276 Census, Compendium Yes 164 0.115 373 41 0.11 2
XPA XPA P23025 DNA repair protein complementing XP-A cells chr9 GO:0051276 Census Yes 27 0.099 121 13 0.107 5
XRCC1 XRCC1 P18887 DNA repair protein XRCC1 chr19 GO:0051276 Not Cancer Driver No 85 0.134 426 53 0.124 1
XRCC3_ENST00000352127 XRCC3 O43542 DNA repair protein XRCC3 chr14 GO:0051276 Not Cancer Driver No 24 0.069 35 2 0.057 1
ZMPSTE24 ZMPSTE24 O75844 CAAX prenyl protease 1 homolog chr1 GO:0051276 Not Cancer Driver No 67 0.141 23 0 0.0 3
ZNF830 ZNF830 Q96NB3 Zinc finger protein 830 chr17 GO:0051276 Not Cancer Driver No 39 0.105 312 37 0.119 0
ZRANB3 ZRANB3 Q5FWF4 DNA annealing helicase and endonuclease ZRANB3 chr2 GO:0051276 Not Cancer Driver No 126 0.117 261 31 0.119 0