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Total number of protein in "GO:0051091" GO term:  140

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
ABRA ABRA Q8N0Z2 Actin-binding Rho-activating protein chr8 GO:0051091 Not Cancer Driver No 108 0.283 285 86 0.302 0
ADCY1 ADCY1 Q08828 Adenylate cyclase type 1 chr7 GO:0051091 Not Cancer Driver No 244 0.218 99 19 0.192 0
ADCY8 ADCY8 P40145 Adenylate cyclase type 8 chr8 GO:0051091 Not Cancer Driver No 419 0.335 215 38 0.177 0
ADGRF1 ADGRF1 Q5T601 Adhesion G-protein coupled receptor F1 chr6 GO:0051091 Not Cancer Driver No 159 0.175 8 0 0.0 0
AKT1_ENST00000349310 AKT1 P31749 RAC-alpha serine/threonine-protein kinase chr14 GO:0051091 Census, Compendium Yes 108 0.225 158 24 0.152 4
ANXA3 ANXA3 P12429 Annexin A3 chr4 GO:0051091 Not Cancer Driver No 53 0.164 22 4 0.182 0
APP APP P05067 Amyloid-beta precursor protein chr21 GO:0051091 Not Cancer Driver No 128 0.166 418 71 0.17 17
ARHGEF5 ARHGEF5 Q12774 Rho guanine nucleotide exchange factor 5 chr7 GO:0051091 Not Cancer Driver No 170 0.106 1141 127 0.111 0
ARID5B ARID5B Q14865 AT-rich interactive domain-containing protein 5B chr10 GO:0051091 Not Cancer Driver No 162 0.136 769 95 0.124 0
ATF2 ATF2 P15336 Cyclic AMP-dependent transcription factor ATF-2 chr2 GO:0051091 Not Cancer Driver No 65 0.129 451 58 0.129 0
BEX1 BEX1 Q9HBH7 Protein BEX1 chrX GO:0051091 Not Cancer Driver No 26 0.208 113 24 0.212 0
BMP2 BMP2 P12643 Bone morphogenetic protein 2 chr20 GO:0051091 Not Cancer Driver No 73 0.184 139 26 0.187 0
BUD31 BUD31 P41223 Protein BUD31 homolog chr7 GO:0051091 Not Cancer Driver No 20 0.139 32 4 0.125 0
CAMK1D CAMK1D Q8IU85 Calcium/calmodulin-dependent protein kinase type 1D chr10 GO:0051091 Not Cancer Driver No 90 0.234 42 14 0.333 0
CD200_ENST00000315711 CD200 P41217 OX-2 membrane glycoprotein chr3 GO:0051091 Not Cancer Driver No 37 0.133 14 0 0.0 0
CEBPG_ENST00000585933 CEBPG P53567 CCAAT/enhancer-binding protein gamma chr19 GO:0051091 Not Cancer Driver No 13 0.087 141 12 0.085 0
CLEC7A CLEC7A Q9BXN2 C-type lectin domain family 7 member A chr12 GO:0051091 Not Cancer Driver No 43 0.174 46 2 0.043 0
COPS5 COPS5 Q92905 COP9 signalosome complex subunit 5 chr8 GO:0051091 Not Cancer Driver No 36 0.108 32 7 0.219 0
CRTC1_ENST00000321949 CRTC1 Q6UUV9 CREB-regulated transcription coactivator 1 chr19 GO:0051091 Census, Compendium Yes 63 0.099 606 62 0.102 0
CRTC2 CRTC2 Q53ET0 CREB-regulated transcription coactivator 2 chr1 GO:0051091 Not Cancer Driver No 92 0.133 674 88 0.131 0
CRTC3 CRTC3 Q6UUV7 CREB-regulated transcription coactivator 3 chr15 GO:0051091 Census Yes 70 0.113 608 68 0.112 0
CSF3 CSF3 P09919 Granulocyte colony-stimulating factor chr17 GO:0051091 Not Cancer Driver No 20 0.097 7 0 0.0 0
CTNNB1_ENST00000643977 CTNNB1 P35222 Catenin beta-1 chr3 GO:0051091 Census, Compendium Yes 415 0.531 288 301 1.045 14
CYTL1 CYTL1 Q9NRR1 Cytokine-like protein 1 chr4 GO:0051091 Not Cancer Driver No 29 0.213 1 0 0.0 0
DDIT3_ENST00000623876 DDIT3 P35638 DNA damage-inducible transcript 3 protein chr12 GO:0051091 Census Yes 29 0.172 160 27 0.169 0
DDR2 DDR2 Q16832 Discoidin domain-containing receptor 2 chr1 GO:0051091 Census Yes 192 0.225 118 34 0.288 7
DDX58 DDX58 O95786 Antiviral innate immune response receptor RIG-I chr9 GO:0051091 Not Cancer Driver No 118 0.128 61 10 0.164 2
DVL2 DVL2 O14641 Segment polarity protein dishevelled homolog DVL-2 chr17 GO:0051091 Not Cancer Driver No 96 0.13 514 64 0.125 0
EDN1 EDN1 P05305 Endothelin-1 chr6 GO:0051091 Not Cancer Driver No 37 0.175 97 20 0.206 3
EP300 EP300 Q09472 Histone acetyltransferase p300 chr22 GO:0051091 Census, Compendium Yes 334 0.138 1790 196 0.109 1
EPHA5_ENST00000273854 EPHA5 P54756 Ephrin type-A receptor 5 chr4 GO:0051091 Not Cancer Driver No 341 0.329 83 39 0.47 0
ESR1_ENST00000206249 ESR1 P03372 Estrogen receptor chr6 GO:0051091 Census, Compendium Yes 121 0.203 195 27 0.138 2
ESR2 ESR2 Q92731 Estrogen receptor beta chr14 GO:0051091 Not Cancer Driver No 90 0.17 92 11 0.12 1
FANK1 FANK1 Q8TC84 Fibronectin type 3 and ankyrin repeat domains protein 1 chr10 GO:0051091 Not Cancer Driver No 65 0.188 63 13 0.206 0
FOSL1 FOSL1 P15407 Fos-related antigen 1 chr11 GO:0051091 Not Cancer Driver No 24 0.089 271 24 0.089 0
FOXA1 FOXA1 P55317 Hepatocyte nuclear factor 3-alpha chr14 GO:0051091 Census, Compendium Yes 100 0.212 295 53 0.18 0
FZD1 FZD1 Q9UP38 Frizzled-1 chr7 GO:0051091 Not Cancer Driver No 78 0.121 133 2 0.015 0
FZD2 FZD2 Q14332 Frizzled-2 chr17 GO:0051091 Not Cancer Driver No 85 0.15 47 5 0.106 1
FZD4 FZD4 Q9ULV1 Frizzled-4 chr11 GO:0051091 Not Cancer Driver No 57 0.106 33 5 0.152 19
HCLS1 HCLS1 P14317 Hematopoietic lineage cell-specific protein chr3 GO:0051091 Not Cancer Driver No 103 0.212 446 94 0.211 0
HDAC4 HDAC4 P56524 Histone deacetylase 4 chr2 GO:0051091 Not Cancer Driver No 182 0.168 749 132 0.176 0
HDAC5_ENST00000586802 HDAC5 Q9UQL6 Histone deacetylase 5 chr17 GO:0051091 Not Cancer Driver No 118 0.105 718 73 0.102 0
HIPK2 HIPK2 Q9H2X6 Homeodomain-interacting protein kinase 2 chr7 GO:0051091 Not Cancer Driver No 154 0.129 686 96 0.14 0
HSF1 HSF1 Q00613 Heat shock factor protein 1 chr8 GO:0051091 Not Cancer Driver No 59 0.112 335 37 0.11 0
IKBKE IKBKE Q14164 Inhibitor of nuclear factor kappa-B kinase subunit epsilon chr1 GO:0051091 Not Cancer Driver No 108 0.151 76 13 0.171 0
IL10 IL10 P22301 Interleukin-10 chr1 GO:0051091 Not Cancer Driver No 19 0.107 23 1 0.043 0
IL1B IL1B P01584 Interleukin-1 beta chr2 GO:0051091 Not Cancer Driver No 39 0.145 16 3 0.188 0
IL5 IL5 P05113 Interleukin-5 chr5 GO:0051091 Not Cancer Driver No 13 0.097 0 0 0.0 0
IL6 IL6 P05231 Interleukin-6 chr7 GO:0051091 Not Cancer Driver No 35 0.165 58 7 0.121 0
JAK2 JAK2 O60674 Tyrosine-protein kinase JAK2 chr9 GO:0051091 Census, Compendium Yes 136 0.12 59 5 0.085 5
JMY JMY Q8N9B5 Junction-mediating and -regulatory protein chr5 GO:0051091 Not Cancer Driver No 88 0.089 572 52 0.091 0
JUP JUP P14923 Junction plakoglobin chr17 GO:0051091 Not Cancer Driver No 112 0.15 241 37 0.154 0
KDM1A_ENST00000356634 KDM1A O60341 Lysine-specific histone demethylase 1A chr1 GO:0051091 Not Cancer Driver No 67 0.079 291 28 0.096 3
KIT KIT P10721 Mast/stem cell growth factor receptor Kit chr4 GO:0051091 Census, Compendium Yes 226 0.232 83 33 0.398 21
LPAR5 LPAR5 Q9H1C0 Lysophosphatidic acid receptor 5 chr12 GO:0051091 Not Cancer Driver No 40 0.108 57 7 0.123 0
LRP5 LRP5 O75197 Low-density lipoprotein receptor-related protein 5 chr11 GO:0051091 Not Cancer Driver No 253 0.157 188 28 0.149 55
LRP6 LRP6 O75581 Low-density lipoprotein receptor-related protein 6 chr12 GO:0051091 Not Cancer Driver No 206 0.128 255 30 0.118 5
LRP8 LRP8 Q14114 Low-density lipoprotein receptor-related protein 8 chr1 GO:0051091 Not Cancer Driver No 94 0.098 190 24 0.126 0
MAVS MAVS Q7Z434 Mitochondrial antiviral-signaling protein chr20 GO:0051091 Not Cancer Driver No 70 0.13 411 58 0.141 0
MBTPS2 MBTPS2 O43462 Membrane-bound transcription factor site-2 protease chrX GO:0051091 Not Cancer Driver No 63 0.121 16 4 0.25 9
MID2 MID2 Q9UJV3 Probable E3 ubiquitin-protein ligase MID2 chrX GO:0051091 Not Cancer Driver No 112 0.152 95 24 0.253 1
MYOCD_ENST00000343344 MYOCD Q8IZQ8 Myocardin chr17 GO:0051091 Not Cancer Driver No 284 0.303 853 263 0.308 0
NDP_ENST00000642620 NDP Q00604 Norrin chrX GO:0051091 Not Cancer Driver No 14 0.105 0 0 0.0 60
NEUROD1 NEUROD1 Q13562 Neurogenic differentiation factor 1 chr2 GO:0051091 Not Cancer Driver No 84 0.236 202 52 0.257 2
NEUROD2 NEUROD2 Q15784 Neurogenic differentiation factor 2 chr17 GO:0051091 Not Cancer Driver No 26 0.068 210 14 0.067 2
NEUROG1 NEUROG1 Q92886 Neurogenin-1 chr5 GO:0051091 Not Cancer Driver No 27 0.114 178 18 0.101 0
NEUROG2 NEUROG2 Q9H2A3 Neurogenin-2 chr4 GO:0051091 Not Cancer Driver No 32 0.118 209 29 0.139 0
NFAM1 NFAM1 Q8NET5 NFAT activation molecule 1 chr22 GO:0051091 Not Cancer Driver No 30 0.111 116 18 0.155 0
NHLH2_ENST00000320238 NHLH2 Q02577 Helix-loop-helix protein 2 chr1 GO:0051091 Not Cancer Driver No 19 0.141 83 8 0.096 0
NKX3-1 NKX3-1 Q99801 Homeobox protein Nkx-3.1 chr8 GO:0051091 Not Cancer Driver No 35 0.15 171 16 0.094 0
NKX6-1 NKX6-1 P78426 Homeobox protein Nkx-6.1 chr4 GO:0051091 Not Cancer Driver No 38 0.104 325 34 0.105 0
NODAL NODAL Q96S42 Nodal homolog chr10 GO:0051091 Not Cancer Driver No 40 0.115 34 8 0.235 4
OPRD1 OPRD1 P41143 Delta-type opioid receptor chr1 GO:0051091 Not Cancer Driver No 91 0.245 30 3 0.1 0
PARK7_ENST00000377488 PARK7 Q99497 Parkinson disease protein 7 chr1 GO:0051091 Not Cancer Driver No 11 0.058 30 0 0.0 5
PHB2 PHB2 Q99623 Prohibitin-2 chr12 GO:0051091 Not Cancer Driver No 31 0.104 26 4 0.154 0
PINK1 PINK1 Q9BXM7 Serine/threonine-protein kinase PINK1, mitochondrial chr1 GO:0051091 Not Cancer Driver No 57 0.098 99 13 0.131 23
PLCG2 PLCG2 P16885 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 chr16 GO:0051091 Not Cancer Driver No 248 0.196 142 30 0.211 1
PLPP3 PLPP3 O14495 Phospholipid phosphatase 3 chr1 GO:0051091 Not Cancer Driver No 48 0.154 10 1 0.1 0
PPARG PPARG P37231 Peroxisome proliferator-activated receptor gamma chr3 GO:0051091 Census Yes 72 0.143 44 4 0.091 3
PPARGC1A PPARGC1A Q9UBK2 Peroxisome proliferator-activated receptor gamma coactivator 1-alpha chr4 GO:0051091 Not Cancer Driver No 181 0.227 609 148 0.243 0
PPARGC1B PPARGC1B Q86YN6 Peroxisome proliferator-activated receptor gamma coactivator 1-beta chr5 GO:0051091 Not Cancer Driver No 125 0.122 845 99 0.117 0
PPP2R5B PPP2R5B Q15173 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform chr11 GO:0051091 Not Cancer Driver No 79 0.159 119 9 0.076 0
PPP3CA PPP3CA Q08209 Protein phosphatase 3 catalytic subunit alpha chr4 GO:0051091 Compendium Yes 85 0.163 140 27 0.193 7
PPRC1 PPRC1 Q5VV67 Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 chr10 GO:0051091 Not Cancer Driver No 198 0.119 1473 169 0.115 0
PRKD1_ENST00000616995 PRKD1 Q15139 Serine/threonine-protein kinase D1 chr14 GO:0051091 Census Yes 201 0.22 189 33 0.175 2
PRKD2_ENST00000291281 PRKD2 Q9BZL6 Serine/threonine-protein kinase D2 chr19 GO:0051091 Compendium Yes 118 0.134 246 34 0.138 0
PTEN PTEN P60484 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN chr10 GO:0051091 Census, Compendium Yes 505 1.253 76 4 0.053 41
PYCARD PYCARD Q9ULZ3 Apoptosis-associated speck-like protein containing a CARD chr16 GO:0051091 Not Cancer Driver No 16 0.082 39 4 0.103 0
RELN RELN P78509 Reelin chr7 GO:0051091 Not Cancer Driver No 761 0.22 107 19 0.178 7
RGCC RGCC Q9H4X1 Regulator of cell cycle RGCC chr13 GO:0051091 Not Cancer Driver No 9 0.066 81 7 0.086 0
RNF220_ENST00000361799 RNF220 Q5VTB9 E3 ubiquitin-protein ligase RNF220 chr1 GO:0051091 Not Cancer Driver No 104 0.184 401 75 0.187 0
RPS6KA4 RPS6KA4 O75676 Ribosomal protein S6 kinase alpha-4 chr11 GO:0051091 Not Cancer Driver No 72 0.093 220 11 0.05 0
RPS6KA5 RPS6KA5 O75582 Ribosomal protein S6 kinase alpha-5 chr14 GO:0051091 Not Cancer Driver No 97 0.121 187 18 0.096 0
RWDD1 RWDD1 Q9H446 RWD domain-containing protein 1 chr6 GO:0051091 Not Cancer Driver No 28 0.115 168 19 0.113 0
SAV1 SAV1 Q9H4B6 Protein salvador homolog 1 chr14 GO:0051091 Not Cancer Driver No 42 0.11 243 17 0.07 0
SHH SHH Q15465 Sonic hedgehog protein chr7 GO:0051091 Not Cancer Driver No 56 0.121 139 14 0.101 81
SMAD3 SMAD3 P84022 Mothers against decapentaplegic homolog 3 chr15 GO:0051091 Census, Compendium Yes 97 0.228 111 19 0.171 5
SMARCA4 SMARCA4 P51532 Transcription activator BRG1 chr19 GO:0051091 Census, Compendium Yes 349 0.212 1072 195 0.182 5
SMARCB1_ENST00000644036 SMARCB1 Q12824 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 chr22 GO:0051091 Census, Compendium Yes 64 0.166 141 35 0.248 3
SMO SMO Q99835 Smoothened homolog chr7 GO:0051091 Census, Compendium Yes 112 0.142 241 27 0.112 1
SRF SRF P11831 Serum response factor chr6 GO:0051091 Not Cancer Driver No 44 0.087 443 42 0.095 0
STK36_ENST00000440309 STK36 Q9NRP7 Serine/threonine-protein kinase 36 chr2 GO:0051091 Not Cancer Driver No 167 0.127 250 36 0.144 0
STK3_ENST00000419617 STK3 Q13188 Serine/threonine-protein kinase 3 chr8 GO:0051091 Not Cancer Driver No 70 0.143 241 32 0.133 0
TAF12_ENST00000373824 TAF12 Q16514 Transcription initiation factor TFIID subunit 12 chr1 GO:0051091 Not Cancer Driver No 11 0.068 107 7 0.065 0
TAF1_ENST00000373790 TAF1 P21675 Transcription initiation factor TFIID subunit 1 chrX GO:0051091 Not Cancer Driver No 379 0.202 1152 219 0.19 5
TCF3 TCF3 P15923 Transcription factor E2-alpha chr19 GO:0051091 Census Yes 52 0.08 649 52 0.08 0
TFDP1 TFDP1 Q14186 Transcription factor Dp-1 chr13 GO:0051091 Not Cancer Driver No 82 0.2 245 47 0.192 0
TMEM173 STING1 Q86WV6 Stimulator of interferon genes protein chr5 GO:0051091 Not Cancer Driver No 46 0.121 66 13 0.197 3
TNF TNF P01375 Tumor necrosis factor chr6 GO:0051091 Not Cancer Driver No 24 0.103 45 3 0.067 0
TNFRSF11A TNFRSF11A Q9Y6Q6 Tumor necrosis factor receptor superfamily member 11A chr18 GO:0051091 Not Cancer Driver No 70 0.114 285 33 0.116 0
TNFSF11 TNFSF11 O14788 Tumor necrosis factor ligand superfamily member 11 chr13 GO:0051091 Not Cancer Driver No 52 0.164 56 1 0.018 1
TP53BP1_ENST00000263801 TP53BP1 Q12888 TP53-binding protein 1 chr15 GO:0051091 Not Cancer Driver No 227 0.115 1632 190 0.116 0
TRAF2 TRAF2 Q12933 TNF receptor-associated factor 2 chr9 GO:0051091 Not Cancer Driver No 63 0.126 4 1 0.25 0
TRAF5_ENST00000336184 TRAF5 O00463 TNF receptor-associated factor 5 chr1 GO:0051091 Not Cancer Driver No 61 0.11 59 5 0.085 0
TRAF6_ENST00000348124 TRAF6 Q9Y4K3 TNF receptor-associated factor 6 chr11 GO:0051091 Not Cancer Driver No 67 0.128 62 7 0.113 0
TRIM14 TRIM14 Q14142 Tripartite motif-containing protein 14 chr9 GO:0051091 Not Cancer Driver No 36 0.081 93 7 0.075 0
TRIM15 TRIM15 Q9C019 Tripartite motif-containing protein 15 chr6 GO:0051091 Not Cancer Driver No 69 0.148 79 11 0.139 0
TRIM21 TRIM21 P19474 E3 ubiquitin-protein ligase TRIM21 chr11 GO:0051091 Not Cancer Driver No 85 0.179 49 7 0.143 0
TRIM22 TRIM22 Q8IYM9 E3 ubiquitin-protein ligase TRIM22 chr11 GO:0051091 Not Cancer Driver No 93 0.187 26 1 0.038 0
TRIM25 TRIM25 Q14258 E3 ubiquitin/ISG15 ligase TRIM25 chr17 GO:0051091 Not Cancer Driver No 59 0.094 225 20 0.089 0
TRIM26 TRIM26 Q12899 Tripartite motif-containing protein 26 chr6 GO:0051091 Not Cancer Driver No 67 0.124 153 16 0.105 0
TRIM27 TRIM27 P14373 Zinc finger protein RFP chr6 GO:0051091 Census Yes 59 0.115 87 11 0.126 0
TRIM31 TRIM31 Q9BZY9 E3 ubiquitin-protein ligase TRIM31 chr6 GO:0051091 Not Cancer Driver No 55 0.129 152 21 0.138 0
TRIM32 TRIM32 Q13049 E3 ubiquitin-protein ligase TRIM32 chr9 GO:0051091 Not Cancer Driver No 82 0.126 87 10 0.115 3
TRIM34_ENST00000429814 TRIM34 Q9BYJ4 Tripartite motif-containing protein 34 chr11 GO:0051091 Not Cancer Driver No 74 0.152 32 2 0.062 0
TRIM37 TRIM37 O94972 E3 ubiquitin-protein ligase TRIM37 chr17 GO:0051091 Not Cancer Driver No 119 0.123 492 60 0.122 3
TRIM38 TRIM38 O00635 E3 ubiquitin-protein ligase TRIM38 chr6 GO:0051091 Not Cancer Driver No 62 0.133 47 8 0.17 0
TRIM41 TRIM41 Q8WV44 E3 ubiquitin-protein ligase TRIM41 chr5 GO:0051091 Not Cancer Driver No 69 0.11 385 38 0.099 0
TRIM5 TRIM5 Q9C035 Tripartite motif-containing protein 5 chr11 GO:0051091 Not Cancer Driver No 71 0.144 77 11 0.143 0
TRIM52 TRIM52 Q96A61 E3 ubiquitin-protein ligase TRIM52 chr5 GO:0051091 Not Cancer Driver No 23 0.077 147 13 0.088 0
TRIM62 TRIM62 Q9BVG3 E3 ubiquitin-protein ligase TRIM62 chr1 GO:0051091 Not Cancer Driver No 58 0.122 80 14 0.175 0
TRIM8 TRIM8 Q9BZR9 E3 ubiquitin-protein ligase TRIM8 chr10 GO:0051091 Not Cancer Driver No 60 0.109 209 29 0.139 0
TSSK4_ENST00000287913 TSSK4 Q6SA08 Testis-specific serine/threonine-protein kinase 4 chr14 GO:0051091 Not Cancer Driver No 29 0.088 8 1 0.125 0
VEGFA_ENST00000523873 VEGFA P15692 Vascular endothelial growth factor A chr6 GO:0051091 Not Cancer Driver No 27 0.116 41 7 0.171 0
WNT1 WNT1 P04628 Proto-oncogene Wnt-1 chr12 GO:0051091 Not Cancer Driver No 29 0.078 25 0 0.0 8
WNT10B WNT10B O00744 Protein Wnt-10b chr12 GO:0051091 Not Cancer Driver No 56 0.144 84 16 0.19 2
WNT2 WNT2 P09544 Protein Wnt-2 chr7 GO:0051091 Not Cancer Driver No 85 0.236 11 3 0.273 0
WNT3A WNT3A P56704 Protein Wnt-3a chr1 GO:0051091 Not Cancer Driver No 77 0.219 37 5 0.135 0
ZC4H2 ZC4H2 Q9NQZ6 Zinc finger C4H2 domain-containing protein chrX GO:0051091 Not Cancer Driver No 60 0.268 136 43 0.316 13
ZIC2 ZIC2 O95409 Zinc finger protein ZIC 2 chr13 GO:0051091 Not Cancer Driver No 40 0.075 387 23 0.059 21