Total number of protein in "GO:0050868" GO term: 91
| Identifier | UniProt Gene | UniProt Accession | UniProt Name | Chromosome | GO term | Database | Cancer Driver | Number of missense mutations | Missense mutation per residues | Number of disordered residues | Number of mutations in disordered regions | Disordered missense mutations per residues | Number of OMIM mutation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ADORA2A | ADORA2A | P29274 | Adenosine receptor A2a | chr22 | GO:0050868 | Not Cancer Driver | No | 61 | 0.148 | 93 | 11 | 0.118 | 0 |
| ANXA1_ENST00000257497 | ANXA1 | P04083 | Annexin A1 | chr9 | GO:0050868 | Not Cancer Driver | No | 59 | 0.171 | 61 | 12 | 0.197 | 0 |
| ARG1_ENST00000368087 | ARG1 | P05089 | Arginase-1 | chr6 | GO:0050868 | Not Cancer Driver | No | 41 | 0.127 | 83 | 12 | 0.145 | 9 |
| ARG2 | ARG2 | P78540 | Arginase-2, mitochondrial | chr14 | GO:0050868 | Not Cancer Driver | No | 25 | 0.071 | 58 | 3 | 0.052 | 0 |
| BCL6_ENST00000232014 | BCL6 | P41182 | B-cell lymphoma 6 protein | chr3 | GO:0050868 | Census, Compendium | Yes | 134 | 0.19 | 328 | 67 | 0.204 | 0 |
| BMP4 | BMP4 | P12644 | Bone morphogenetic protein 4 | chr14 | GO:0050868 | Not Cancer Driver | No | 86 | 0.211 | 142 | 26 | 0.183 | 5 |
| BTN2A2 | BTN2A2 | Q8WVV5 | Butyrophilin subfamily 2 member A2 | chr6 | GO:0050868 | Not Cancer Driver | No | 92 | 0.176 | 24 | 2 | 0.083 | 0 |
| CASP3 | CASP3 | P42574 | Caspase-3 | chr4 | GO:0050868 | Census | Yes | 32 | 0.116 | 62 | 5 | 0.081 | 0 |
| CBFB_ENST00000290858 | CBFB | Q13951 | Core-binding factor subunit beta | chr16 | GO:0050868 | Census, Compendium | Yes | 39 | 0.214 | 94 | 17 | 0.181 | 0 |
| CBLB | CBLB | Q13191 | E3 ubiquitin-protein ligase CBL-B | chr3 | GO:0050868 | Census | Yes | 160 | 0.163 | 562 | 104 | 0.185 | 0 |
| CD274 | CD274 | Q9NZQ7 | Programmed cell death 1 ligand 1 | chr9 | GO:0050868 | Census | Yes | 29 | 0.1 | 54 | 9 | 0.167 | 0 |
| CD300A | CD300A | Q9UGN4 | CMRF35-like molecule 8 | chr17 | GO:0050868 | Not Cancer Driver | No | 53 | 0.177 | 70 | 10 | 0.143 | 0 |
| CD74 | CD74 | P04233 | HLA class II histocompatibility antigen gamma chain | chr5 | GO:0050868 | Census | Yes | 31 | 0.105 | 185 | 20 | 0.108 | 0 |
| CEACAM1 | CEACAM1 | P13688 | Carcinoembryonic antigen-related cell adhesion molecule 1 | chr19 | GO:0050868 | Not Cancer Driver | No | 64 | 0.122 | 241 | 25 | 0.104 | 0 |
| CRTAM | CRTAM | O95727 | Cytotoxic and regulatory T-cell molecule | chr11 | GO:0050868 | Not Cancer Driver | No | 64 | 0.163 | 135 | 14 | 0.104 | 0 |
| CTLA4 | CTLA4 | P16410 | Cytotoxic T-lymphocyte protein 4 | chr2 | GO:0050868 | Not Cancer Driver | No | 37 | 0.166 | 3 | 0 | 0.0 | 1 |
| CTSG | CTSG | P08311 | Cathepsin G | chr14 | GO:0050868 | Not Cancer Driver | No | 65 | 0.255 | 80 | 29 | 0.362 | 0 |
| DUSP22_ENST00000344450 | DUSP22 | Q9NRW4 | Dual specificity protein phosphatase 22 | chr6 | GO:0050868 | Not Cancer Driver | No | 84 | 0.457 | 0 | 0 | 0.0 | 0 |
| DUSP3 | DUSP3 | P51452 | Dual specificity protein phosphatase 3 | chr17 | GO:0050868 | Not Cancer Driver | No | 21 | 0.114 | 4 | 1 | 0.25 | 0 |
| ERBB2 | ERBB2 | P04626 | Receptor tyrosine-protein kinase erbB-2 | chr17 | GO:0050868 | Census, Compendium | Yes | 275 | 0.219 | 314 | 41 | 0.131 | 1 |
| FCGR2B | FCGR2B | P31994 | Low affinity immunoglobulin gamma Fc region receptor II-b | chr1 | GO:0050868 | Census | Yes | 51 | 0.165 | 99 | 30 | 0.303 | 0 |
| FGL1_ENST00000381840 | FGL1 | Q08830 | Fibrinogen-like protein 1 | chr8 | GO:0050868 | Not Cancer Driver | No | 42 | 0.135 | 10 | 2 | 0.2 | 0 |
| FGL2 | FGL2 | Q14314 | Fibroleukin | chr7 | GO:0050868 | Not Cancer Driver | No | 71 | 0.162 | 70 | 12 | 0.171 | 0 |
| FOXJ1 | FOXJ1 | Q92949 | Forkhead box protein J1 | chr17 | GO:0050868 | Not Cancer Driver | No | 25 | 0.059 | 279 | 18 | 0.065 | 0 |
| FOXP3 | FOXP3 | Q9BZS1 | Forkhead box protein P3 | chrX | GO:0050868 | Not Cancer Driver | No | 38 | 0.088 | 186 | 16 | 0.086 | 10 |
| GLI3 | GLI3 | P10071 | Transcriptional activator GLI3 | chr7 | GO:0050868 | Not Cancer Driver | No | 385 | 0.244 | 1352 | 327 | 0.242 | 7 |
| GPNMB | GPNMB | Q14956 | Transmembrane glycoprotein NMB | chr7 | GO:0050868 | Not Cancer Driver | No | 89 | 0.156 | 94 | 18 | 0.191 | 0 |
| HAVCR2 | HAVCR2 | Q8TDQ0 | Hepatitis A virus cellular receptor 2 | chr5 | GO:0050868 | Not Cancer Driver | No | 69 | 0.229 | 17 | 2 | 0.118 | 3 |
| HFE | HFE | Q30201 | Hereditary hemochromatosis protein | chr6 | GO:0050868 | Not Cancer Driver | No | 55 | 0.158 | 27 | 2 | 0.074 | 11 |
| HLX | HLX | Q14774 | H2.0-like homeobox protein | chr1 | GO:0050868 | Not Cancer Driver | No | 107 | 0.219 | 412 | 98 | 0.238 | 0 |
| HMGB1_ENST00000405805 | HMGB1 | P09429 | High mobility group protein B1 | chr13 | GO:0050868 | Not Cancer Driver | No | 25 | 0.116 | 203 | 20 | 0.099 | 0 |
| IFNA2 | IFNA2 | P01563 | Interferon alpha-2 | chr9 | GO:0050868 | Not Cancer Driver | No | 38 | 0.202 | 2 | 0 | 0.0 | 0 |
| IFNB1 | IFNB1 | P01574 | Interferon beta | chr9 | GO:0050868 | Not Cancer Driver | No | 46 | 0.246 | 0 | 0 | 0.0 | 0 |
| IFNL1 | IFNL1 | Q8IU54 | Interferon lambda-1 | chr19 | GO:0050868 | Not Cancer Driver | No | 24 | 0.12 | 49 | 8 | 0.163 | 0 |
| IHH | IHH | Q14623 | Indian hedgehog protein | chr2 | GO:0050868 | Not Cancer Driver | No | 58 | 0.141 | 111 | 15 | 0.135 | 6 |
| IL2 | IL2 | P60568 | Interleukin-2 | chr4 | GO:0050868 | Census | Yes | 24 | 0.157 | 6 | 1 | 0.167 | 0 |
| IL4 | IL4 | P05112 | Interleukin-4 | chr5 | GO:0050868 | Not Cancer Driver | No | 18 | 0.118 | 0 | 0 | 0.0 | 0 |
| IL4I1_ENST00000391826 | IL4I1 | Q96RQ9 | L-amino-acid oxidase | chr19 | GO:0050868 | Not Cancer Driver | No | 65 | 0.115 | 136 | 14 | 0.103 | 0 |
| IL4R_ENST00000543915 | IL4R | P24394 | Interleukin-4 receptor subunit alpha | chr16 | GO:0050868 | Not Cancer Driver | No | 133 | 0.161 | 420 | 64 | 0.152 | 0 |
| ILDR2 | ILDR2 | Q71H61 | Immunoglobulin-like domain-containing receptor 2 | chr1 | GO:0050868 | Not Cancer Driver | No | 117 | 0.183 | 355 | 49 | 0.138 | 0 |
| IRF1 | IRF1 | P10914 | Interferon regulatory factor 1 | chr5 | GO:0050868 | Compendium | Yes | 49 | 0.151 | 228 | 31 | 0.136 | 2 |
| ITCH | ITCH | Q96J02 | E3 ubiquitin-protein ligase Itchy homolog | chr20 | GO:0050868 | Not Cancer Driver | No | 95 | 0.105 | 335 | 42 | 0.125 | 0 |
| JAK3 | JAK3 | P52333 | Tyrosine-protein kinase JAK3 | chr19 | GO:0050868 | Census, Compendium | Yes | 167 | 0.149 | 63 | 10 | 0.159 | 7 |
| LAG3 | LAG3 | P18627 | Lymphocyte activation gene 3 protein | chr12 | GO:0050868 | Not Cancer Driver | No | 47 | 0.09 | 208 | 11 | 0.053 | 0 |
| LAPTM5 | LAPTM5 | Q13571 | Lysosomal-associated transmembrane protein 5 | chr1 | GO:0050868 | Not Cancer Driver | No | 46 | 0.176 | 16 | 6 | 0.375 | 0 |
| LAX1 | LAX1 | Q8IWV1 | Lymphocyte transmembrane adapter 1 | chr1 | GO:0050868 | Not Cancer Driver | No | 61 | 0.153 | 228 | 32 | 0.14 | 0 |
| LGALS3 | LGALS3 | P17931 | Galectin-3 | chr14 | GO:0050868 | Not Cancer Driver | No | 15 | 0.06 | 133 | 6 | 0.045 | 0 |
| LGALS7B | LGALS7B | P47929 | Galectin-7 | chr19 | GO:0050868 | Not Cancer Driver | No | 14 | 0.103 | 54 | 5 | 0.093 | 0 |
| LGALS9 | LGALS9 | O00182 | Galectin-9 | chr17 | GO:0050868 | Not Cancer Driver | No | 54 | 0.152 | 65 | 16 | 0.246 | 0 |
| LGALS9B_ENST00000423676 | LGALS9B | Q3B8N2 | Galectin-9B | chr17 | GO:0050868 | Not Cancer Driver | No | 43 | 0.121 | 86 | 19 | 0.221 | 0 |
| LGALS9C | LGALS9C | Q6DKI2 | Galectin-9C | chr17 | GO:0050868 | Not Cancer Driver | No | 32 | 0.09 | 80 | 6 | 0.075 | 0 |
| LILRB1_ENST00000396331 | LILRB1 | Q8NHL6 | Leukocyte immunoglobulin-like receptor subfamily B member 1 | chr19 | GO:0050868 | Not Cancer Driver | No | 203 | 0.312 | 291 | 97 | 0.333 | 0 |
| LILRB4 | LILRB4 | Q8NHJ6 | Leukocyte immunoglobulin-like receptor subfamily B member 4 | chr19 | GO:0050868 | Not Cancer Driver | No | 162 | 0.362 | 277 | 115 | 0.415 | 0 |
| LOXL3 | LOXL3 | P58215 | Lysyl oxidase homolog 3 | chr2 | GO:0050868 | Not Cancer Driver | No | 91 | 0.121 | 86 | 17 | 0.198 | 0 |
| LRRC32_ENST00000404995 | LRRC32 | Q14392 | Transforming growth factor beta activator LRRC32 | chr11 | GO:0050868 | Not Cancer Driver | No | 130 | 0.196 | 28 | 4 | 0.143 | 0 |
| MDK_ENST00000407067 | MDK | P21741 | Midkine | chr11 | GO:0050868 | Not Cancer Driver | No | 15 | 0.105 | 20 | 2 | 0.1 | 0 |
| NCKAP1L | NCKAP1L | P55160 | Nck-associated protein 1-like | chr12 | GO:0050868 | Not Cancer Driver | No | 247 | 0.219 | 51 | 10 | 0.196 | 4 |
| NRARP | NRARP | Q7Z6K4 | Notch-regulated ankyrin repeat-containing protein | chr9 | GO:0050868 | Not Cancer Driver | No | 9 | 0.079 | 11 | 1 | 0.091 | 0 |
| PAG1 | PAG1 | Q9NWQ8 | Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 | chr8 | GO:0050868 | Not Cancer Driver | No | 58 | 0.134 | 394 | 54 | 0.137 | 0 |
| PDCD1LG2 | PDCD1LG2 | Q9BQ51 | Programmed cell death 1 ligand 2 | chr9 | GO:0050868 | Census, Compendium | Yes | 33 | 0.121 | 41 | 13 | 0.317 | 0 |
| PRDX2 | PRDX2 | P32119 | Peroxiredoxin-2 | chr19 | GO:0050868 | Not Cancer Driver | No | 24 | 0.121 | 30 | 4 | 0.133 | 0 |
| PRKAR1A_ENST00000536854 | PRKAR1A | P10644 | cAMP-dependent protein kinase type I-alpha regulatory subunit | chr17 | GO:0050868 | Census, Compendium | Yes | 39 | 0.102 | 66 | 11 | 0.167 | 17 |
| PRNP | PRNP | P04156 | Major prion protein | chr20 | GO:0050868 | Not Cancer Driver | No | 36 | 0.142 | 115 | 7 | 0.061 | 18 |
| PTPN2 | PTPN2 | P17706 | Tyrosine-protein phosphatase non-receptor type 2 | chr18 | GO:0050868 | Not Cancer Driver | No | 57 | 0.137 | 120 | 14 | 0.117 | 0 |
| PTPN22 | PTPN22 | Q9Y2R2 | Tyrosine-protein phosphatase non-receptor type 22 | chr1 | GO:0050868 | Not Cancer Driver | No | 141 | 0.175 | 364 | 62 | 0.17 | 4 |
| RAG2 | RAG2 | P55895 | V(D)J recombination-activating protein 2 | chr11 | GO:0050868 | Not Cancer Driver | No | 118 | 0.224 | 85 | 23 | 0.271 | 6 |
| RC3H1_ENST00000258349 | RC3H1 | Q5TC82 | Roquin-1 | chr1 | GO:0050868 | Not Cancer Driver | No | 158 | 0.139 | 796 | 115 | 0.144 | 0 |
| RC3H2_ENST00000357244 | RC3H2 | Q9HBD1 | Roquin-2 | chr9 | GO:0050868 | Not Cancer Driver | No | 128 | 0.107 | 703 | 81 | 0.115 | 0 |
| RIPOR2_ENST00000259698 | RIPOR2 | Q9Y4F9 | Rho family-interacting cell polarization regulator 2 | chr6 | GO:0050868 | Not Cancer Driver | No | 131 | 0.123 | 421 | 76 | 0.181 | 0 |
| RUNX1_ENST00000344691 | RUNX1 | Q01196 | Runt-related transcription factor 1 | chr21 | GO:0050868 | Census, Compendium | Yes | 81 | 0.179 | 360 | 58 | 0.161 | 2 |
| RUNX3_ENST00000308873 | RUNX3 | Q13761 | Runt-related transcription factor 3 | chr1 | GO:0050868 | Not Cancer Driver | No | 59 | 0.142 | 331 | 45 | 0.136 | 0 |
| SCRIB_ENST00000320476 | SCRIB | Q14160 | Protein scribble homolog | chr8 | GO:0050868 | Not Cancer Driver | No | 196 | 0.12 | 1064 | 135 | 0.127 | 2 |
| SHH | SHH | Q15465 | Sonic hedgehog protein | chr7 | GO:0050868 | Not Cancer Driver | No | 56 | 0.121 | 139 | 14 | 0.101 | 81 |
| SMAD7 | SMAD7 | O15105 | Mothers against decapentaplegic homolog 7 | chr18 | GO:0050868 | Not Cancer Driver | No | 40 | 0.094 | 139 | 0 | 0.0 | 0 |
| SOCS1 | SOCS1 | O15524 | Suppressor of cytokine signaling 1 | chr16 | GO:0050868 | Census, Compendium | Yes | 22 | 0.104 | 66 | 3 | 0.045 | 2 |
| SOCS5 | SOCS5 | O75159 | Suppressor of cytokine signaling 5 | chr2 | GO:0050868 | Not Cancer Driver | No | 84 | 0.157 | 297 | 46 | 0.155 | 0 |
| SOCS6_ENST00000582322 | SOCS6 | O14544 | Suppressor of cytokine signaling 6 | chr18 | GO:0050868 | Not Cancer Driver | No | 81 | 0.151 | 299 | 48 | 0.161 | 0 |
| TARM1_ENST00000432826 | TARM1 | B6A8C7 | T-cell-interacting, activating receptor on myeloid cells protein 1 | chr19 | GO:0050868 | Not Cancer Driver | No | 13 | 0.048 | 21 | 1 | 0.048 | 0 |
| TBX21 | TBX21 | Q9UL17 | T-box transcription factor TBX21 | chr17 | GO:0050868 | Not Cancer Driver | No | 70 | 0.131 | 348 | 50 | 0.144 | 0 |
| TIGIT | TIGIT | Q495A1 | T-cell immunoreceptor with Ig and ITIM domains | chr3 | GO:0050868 | Not Cancer Driver | No | 60 | 0.246 | 28 | 4 | 0.143 | 0 |
| TMEM131L_ENST00000409663 | TMEM131L | A2VDJ0 | Transmembrane protein 131-like | chr4 | GO:0050868 | Not Cancer Driver | No | 188 | 0.117 | 448 | 47 | 0.105 | 0 |
| TNFAIP8L2 | TNFAIP8L2 | Q6P589 | Tumor necrosis factor alpha-induced protein 8-like protein 2 | chr1 | GO:0050868 | Not Cancer Driver | No | 30 | 0.163 | 0 | 0 | 0.0 | 0 |
| TNFRSF14 | TNFRSF14 | Q92956 | Tumor necrosis factor receptor superfamily member 14 | chr1 | GO:0050868 | Census, Compendium | Yes | 33 | 0.117 | 54 | 8 | 0.148 | 0 |
| TNFSF4 | TNFSF4 | P23510 | Tumor necrosis factor ligand superfamily member 4 | chr1 | GO:0050868 | Not Cancer Driver | No | 28 | 0.153 | 1 | 0 | 0.0 | 0 |
| TWSG1 | TWSG1 | Q9GZX9 | Twisted gastrulation protein homolog 1 | chr18 | GO:0050868 | Not Cancer Driver | No | 27 | 0.121 | 19 | 3 | 0.158 | 0 |
| VSIR | VSIR | Q9H7M9 | V-type immunoglobulin domain-containing suppressor of T-cell activation | chr10 | GO:0050868 | Not Cancer Driver | No | 52 | 0.167 | 135 | 19 | 0.141 | 0 |
| VTCN1 | VTCN1 | Q7Z7D3 | V-set domain-containing T-cell activation inhibitor 1 | chr1 | GO:0050868 | Not Cancer Driver | No | 43 | 0.152 | 3 | 2 | 0.667 | 0 |
| XCL1 | XCL1 | P47992 | Lymphotactin | chr1 | GO:0050868 | Not Cancer Driver | No | 28 | 0.246 | 35 | 11 | 0.314 | 0 |
| ZBTB7B_ENST00000368426 | ZBTB7B | O15156 | Zinc finger and BTB domain-containing protein 7B | chr1 | GO:0050868 | Compendium | Yes | 103 | 0.191 | 353 | 70 | 0.198 | 0 |
| ZC3H12A | ZC3H12A | Q5D1E8 | Endoribonuclease ZC3H12A | chr1 | GO:0050868 | Not Cancer Driver | No | 90 | 0.15 | 396 | 44 | 0.111 | 0 |
| ZC3H8 | ZC3H8 | Q8N5P1 | Zinc finger CCCH domain-containing protein 8 | chr2 | GO:0050868 | Not Cancer Driver | No | 22 | 0.076 | 187 | 17 | 0.091 | 0 |