Total number of protein in "GO:0050852" GO term: 90
| Identifier | UniProt Gene | UniProt Accession | UniProt Name | Chromosome | GO term | Database | Cancer Driver | Number of missense mutations | Missense mutation per residues | Number of disordered residues | Number of mutations in disordered regions | Disordered missense mutations per residues | Number of OMIM mutation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ABL1_ENST00000318560 | ABL1 | P00519 | Tyrosine-protein kinase ABL1 | chr9 | GO:0050852 | Census, Compendium | Yes | 139 | 0.123 | 604 | 73 | 0.121 | 2 |
| BCAR1_ENST00000162330 | BCAR1 | P56945 | Breast cancer anti-estrogen resistance protein 1 | chr16 | GO:0050852 | Not Cancer Driver | No | 108 | 0.124 | 677 | 75 | 0.111 | 0 |
| BCL10 | BCL10 | O95999 | B-cell lymphoma/leukemia 10 | chr1 | GO:0050852 | Census, Compendium | Yes | 36 | 0.155 | 151 | 25 | 0.166 | 0 |
| BTN1A1 | BTN1A1 | Q13410 | Butyrophilin subfamily 1 member A1 | chr6 | GO:0050852 | Not Cancer Driver | No | 116 | 0.221 | 89 | 16 | 0.18 | 0 |
| BTN2A1 | BTN2A1 | Q7KYR7 | Butyrophilin subfamily 2 member A1 | chr6 | GO:0050852 | Not Cancer Driver | No | 86 | 0.163 | 38 | 9 | 0.237 | 0 |
| BTN2A2 | BTN2A2 | Q8WVV5 | Butyrophilin subfamily 2 member A2 | chr6 | GO:0050852 | Not Cancer Driver | No | 92 | 0.176 | 24 | 2 | 0.083 | 0 |
| BTN3A1 | BTN3A1 | O00481 | Butyrophilin subfamily 3 member A1 | chr6 | GO:0050852 | Not Cancer Driver | No | 77 | 0.15 | 72 | 18 | 0.25 | 0 |
| BTN3A2 | BTN3A2 | P78410 | Butyrophilin subfamily 3 member A2 | chr6 | GO:0050852 | Not Cancer Driver | No | 63 | 0.189 | 45 | 6 | 0.133 | 0 |
| BTN3A3 | BTN3A3 | O00478 | Butyrophilin subfamily 3 member A3 | chr6 | GO:0050852 | Not Cancer Driver | No | 85 | 0.146 | 142 | 29 | 0.204 | 0 |
| BTNL2_ENST00000374993 | BTNL2 | Q9UIR0 | Butyrophilin-like protein 2 | chr6 | GO:0050852 | Not Cancer Driver | No | 66 | 0.145 | 82 | 16 | 0.195 | 0 |
| BTNL3 | BTNL3 | Q6UXE8 | Butyrophilin-like protein 3 | chr5 | GO:0050852 | Not Cancer Driver | No | 79 | 0.17 | 50 | 13 | 0.26 | 0 |
| BTNL8 | BTNL8 | Q6UX41 | Butyrophilin-like protein 8 | chr5 | GO:0050852 | Not Cancer Driver | No | 132 | 0.264 | 84 | 22 | 0.262 | 0 |
| BTNL9 | BTNL9 | Q6UXG8 | Butyrophilin-like protein 9 | chr5 | GO:0050852 | Not Cancer Driver | No | 69 | 0.129 | 87 | 4 | 0.046 | 0 |
| CACNB3 | CACNB3 | P54284 | Voltage-dependent L-type calcium channel subunit beta-3 | chr12 | GO:0050852 | Not Cancer Driver | No | 58 | 0.12 | 258 | 30 | 0.116 | 0 |
| CBLB | CBLB | Q13191 | E3 ubiquitin-protein ligase CBL-B | chr3 | GO:0050852 | Census | Yes | 160 | 0.163 | 562 | 104 | 0.185 | 0 |
| CD247 | CD247 | P20963 | T-cell surface glycoprotein CD3 zeta chain | chr1 | GO:0050852 | Not Cancer Driver | No | 33 | 0.201 | 91 | 24 | 0.264 | 0 |
| CD276 | CD276 | Q5ZPR3 | CD276 antigen | chr15 | GO:0050852 | Not Cancer Driver | No | 62 | 0.116 | 139 | 10 | 0.072 | 0 |
| CD28 | CD28 | P10747 | T-cell-specific surface glycoprotein CD28 | chr2 | GO:0050852 | Census | Yes | 42 | 0.191 | 18 | 10 | 0.556 | 0 |
| CD8A_ENST00000283635 | CD8A | P01732 | T-cell surface glycoprotein CD8 alpha chain | chr2 | GO:0050852 | Not Cancer Driver | No | 33 | 0.14 | 28 | 2 | 0.071 | 1 |
| CD8B_ENST00000390655 | CD8B | P10966 | T-cell surface glycoprotein CD8 beta chain | chr2 | GO:0050852 | Not Cancer Driver | No | 37 | 0.176 | 10 | 0 | 0.0 | 0 |
| CRKL | CRKL | P46109 | Crk-like protein | chr22 | GO:0050852 | Not Cancer Driver | No | 38 | 0.125 | 160 | 25 | 0.156 | 0 |
| CSK_ENST00000439220 | CSK | P41240 | Tyrosine-protein kinase CSK | chr15 | GO:0050852 | Not Cancer Driver | No | 41 | 0.091 | 18 | 1 | 0.056 | 0 |
| CTLA4 | CTLA4 | P16410 | Cytotoxic T-lymphocyte protein 4 | chr2 | GO:0050852 | Not Cancer Driver | No | 37 | 0.166 | 3 | 0 | 0.0 | 1 |
| DENND1B | DENND1B | Q6P3S1 | DENN domain-containing protein 1B | chr1 | GO:0050852 | Not Cancer Driver | No | 69 | 0.089 | 299 | 19 | 0.064 | 0 |
| EIF2B1 | EIF2B1 | Q14232 | Translation initiation factor eIF-2B subunit alpha | chr12 | GO:0050852 | Not Cancer Driver | No | 33 | 0.108 | 0 | 0 | 0.0 | 2 |
| EIF2B2 | EIF2B2 | P49770 | Translation initiation factor eIF-2B subunit beta | chr14 | GO:0050852 | Not Cancer Driver | No | 40 | 0.114 | 83 | 11 | 0.133 | 9 |
| EIF2B3 | EIF2B3 | Q9NR50 | Translation initiation factor eIF-2B subunit gamma | chr1 | GO:0050852 | Not Cancer Driver | No | 54 | 0.119 | 28 | 9 | 0.321 | 5 |
| EIF2B4_ENST00000347454 | EIF2B4 | Q9UI10 | Translation initiation factor eIF-2B subunit delta | chr2 | GO:0050852 | Not Cancer Driver | No | 57 | 0.109 | 212 | 29 | 0.137 | 7 |
| EIF2B5 | EIF2B5 | Q13144 | Translation initiation factor eIF-2B subunit epsilon | chr3 | GO:0050852 | Not Cancer Driver | No | 76 | 0.105 | 179 | 16 | 0.089 | 29 |
| ERMAP_ENST00000372514 | ERMAP | Q96PL5 | Erythroid membrane-associated protein | chr1 | GO:0050852 | Not Cancer Driver | No | 55 | 0.116 | 48 | 5 | 0.104 | 0 |
| FCHO1_ENST00000600676 | FCHO1 | O14526 | F-BAR domain only protein 1 | chr19 | GO:0050852 | Not Cancer Driver | No | 127 | 0.143 | 533 | 69 | 0.129 | 2 |
| FOXP3 | FOXP3 | Q9BZS1 | Forkhead box protein P3 | chrX | GO:0050852 | Not Cancer Driver | No | 38 | 0.088 | 186 | 16 | 0.086 | 10 |
| FYB1_ENST00000515010 | FYB1 | O15117 | FYN-binding protein 1 | chr5 | GO:0050852 | Not Cancer Driver | No | 176 | 0.225 | 687 | 161 | 0.234 | 0 |
| FYB2 | FYB2 | Q5VWT5 | FYN-binding protein 2 | chr1 | GO:0050852 | Not Cancer Driver | No | 150 | 0.206 | 547 | 124 | 0.227 | 0 |
| FYN | FYN | P06241 | Tyrosine-protein kinase Fyn | chr6 | GO:0050852 | Not Cancer Driver | No | 92 | 0.171 | 70 | 13 | 0.186 | 0 |
| GATA3_ENST00000346208 | GATA3 | P23771 | Trans-acting T-cell-specific transcription factor GATA-3 | chr10 | GO:0050852 | Census, Compendium | Yes | 111 | 0.251 | 364 | 87 | 0.239 | 2 |
| HHLA2_ENST00000489514 | HHLA2 | Q9UM44 | HERV-H LTR-associating protein 2 | chr3 | GO:0050852 | Not Cancer Driver | No | 85 | 0.205 | 57 | 10 | 0.175 | 0 |
| HLA-A_ENST00000376809 | HLA-A | P04439 | HLA class I histocompatibility antigen, A alpha chain | chr6 | GO:0050852 | Census, Compendium | Yes | 128 | 0.351 | 125 | 60 | 0.48 | 0 |
| HLA-DPB1 | HLA-DPB1 | P04440 | HLA class II histocompatibility antigen, DP beta 1 chain | chr6 | GO:0050852 | Not Cancer Driver | No | 38 | 0.147 | 39 | 4 | 0.103 | 0 |
| HLA-DRB1 | HLA-DRB1 | P01911 | HLA class II histocompatibility antigen, DRB1 beta chain | chr6 | GO:0050852 | Not Cancer Driver | No | 48 | 0.18 | 12 | 1 | 0.083 | 0 |
| HRAS | HRAS | P01112 | GTPase HRas | chr11 | GO:0050852 | Census, Compendium | Yes | 107 | 0.566 | 16 | 4 | 0.25 | 18 |
| ICOSLG_ENST00000407780 | ICOSLG | O75144 | ICOS ligand | chr21 | GO:0050852 | Not Cancer Driver | No | 25 | 0.083 | 30 | 2 | 0.067 | 0 |
| IKBKB | IKBKB | O14920 | Inhibitor of nuclear factor kappa-B kinase subunit beta | chr8 | GO:0050852 | Census, Compendium | Yes | 106 | 0.14 | 211 | 31 | 0.147 | 1 |
| IKBKG_ENST00000611071 | IKBKG | Q9Y6K9 | NF-kappa-B essential modulator | chrX | GO:0050852 | Not Cancer Driver | No | 6 | 0.014 | 301 | 6 | 0.02 | 22 |
| INPP5D | INPP5D | Q92835 | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 | chr2 | GO:0050852 | Not Cancer Driver | No | 176 | 0.148 | 578 | 90 | 0.156 | 0 |
| ITK | ITK | Q08881 | Tyrosine-protein kinase ITK/TSK | chr5 | GO:0050852 | Census | Yes | 139 | 0.224 | 43 | 10 | 0.233 | 1 |
| KHDRBS1 | KHDRBS1 | Q07666 | KH domain-containing, RNA-binding, signal transduction-associated protein 1 | chr1 | GO:0050852 | Not Cancer Driver | No | 53 | 0.12 | 362 | 43 | 0.119 | 0 |
| LCK | LCK | P06239 | Tyrosine-protein kinase Lck | chr1 | GO:0050852 | Census | Yes | 86 | 0.169 | 94 | 13 | 0.138 | 1 |
| LCP2 | LCP2 | Q13094 | Lymphocyte cytosolic protein 2 | chr5 | GO:0050852 | Not Cancer Driver | No | 107 | 0.201 | 390 | 80 | 0.205 | 0 |
| LIME1 | LIME1 | Q9H400 | Lck-interacting transmembrane adapter 1 | chr20 | GO:0050852 | Not Cancer Driver | No | 22 | 0.075 | 193 | 17 | 0.088 | 0 |
| MALT1 | MALT1 | Q9UDY8 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | chr18 | GO:0050852 | Census, Compendium | Yes | 75 | 0.091 | 139 | 12 | 0.086 | 1 |
| MAP3K7 | MAP3K7 | O43318 | Mitogen-activated protein kinase kinase kinase 7 | chr6 | GO:0050852 | Not Cancer Driver | No | 104 | 0.172 | 333 | 66 | 0.198 | 6 |
| MAPK1_ENST00000398822 | MAPK1 | P28482 | Mitogen-activated protein kinase 1 | chr22 | GO:0050852 | Census, Compendium | Yes | 62 | 0.172 | 2 | 0 | 0.0 | 7 |
| MOG_ENST00000376917 | MOG | Q16653 | Myelin-oligodendrocyte glycoprotein | chr6 | GO:0050852 | Not Cancer Driver | No | 57 | 0.231 | 13 | 2 | 0.154 | 1 |
| NFKBID | NFKBID | Q8NI38 | NF-kappa-B inhibitor delta | chr19 | GO:0050852 | Not Cancer Driver | No | 47 | 0.15 | 124 | 20 | 0.161 | 0 |
| NFKBIZ | NFKBIZ | Q9BYH8 | NF-kappa-B inhibitor zeta | chr3 | GO:0050852 | Not Cancer Driver | No | 96 | 0.134 | 443 | 53 | 0.12 | 0 |
| PDE4B | PDE4B | Q07343 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | chr1 | GO:0050852 | Not Cancer Driver | No | 119 | 0.162 | 363 | 42 | 0.116 | 0 |
| PDE4D | PDE4D | Q08499 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | chr5 | GO:0050852 | Not Cancer Driver | No | 86 | 0.106 | 464 | 54 | 0.116 | 12 |
| PIK3CA | PIK3CA | P42336 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | chr3 | GO:0050852 | Census, Compendium | Yes | 1669 | 1.563 | 38 | 11 | 0.289 | 30 |
| PIK3CD | PIK3CD | O00329 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | chr1 | GO:0050852 | Not Cancer Driver | No | 140 | 0.134 | 60 | 13 | 0.217 | 1 |
| PLCG1_ENST00000373271 | PLCG1 | P19174 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | chr20 | GO:0050852 | Census, Compendium | Yes | 158 | 0.122 | 186 | 21 | 0.113 | 0 |
| PLCG2 | PLCG2 | P16885 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 | chr16 | GO:0050852 | Not Cancer Driver | No | 248 | 0.196 | 142 | 30 | 0.211 | 1 |
| PRAM1 | PRAM1 | Q96QH2 | PML-RARA-regulated adapter molecule 1 | chr19 | GO:0050852 | Not Cancer Driver | No | 118 | 0.176 | 628 | 117 | 0.186 | 0 |
| PRKD2_ENST00000291281 | PRKD2 | Q9BZL6 | Serine/threonine-protein kinase D2 | chr19 | GO:0050852 | Compendium | Yes | 118 | 0.134 | 246 | 34 | 0.138 | 0 |
| PSEN1 | PSEN1 | P49768 | Presenilin-1 | chr14 | GO:0050852 | Not Cancer Driver | No | 61 | 0.131 | 134 | 21 | 0.157 | 96 |
| PTPN22 | PTPN22 | Q9Y2R2 | Tyrosine-protein phosphatase non-receptor type 22 | chr1 | GO:0050852 | Not Cancer Driver | No | 141 | 0.175 | 364 | 62 | 0.17 | 4 |
| PTPRC | PTPRC | P08575 | Receptor-type tyrosine-protein phosphatase C | chr1 | GO:0050852 | Census, Compendium | Yes | 315 | 0.241 | 462 | 107 | 0.232 | 0 |
| PTPRJ | PTPRJ | Q12913 | Receptor-type tyrosine-protein phosphatase eta | chr11 | GO:0050852 | Not Cancer Driver | No | 184 | 0.138 | 401 | 61 | 0.152 | 0 |
| RBCK1 | RBCK1 | Q9BYM8 | RanBP-type and C3HC4-type zinc finger-containing protein 1 | chr20 | GO:0050852 | Not Cancer Driver | No | 52 | 0.102 | 140 | 14 | 0.1 | 2 |
| RC3H1_ENST00000258349 | RC3H1 | Q5TC82 | Roquin-1 | chr1 | GO:0050852 | Not Cancer Driver | No | 158 | 0.139 | 796 | 115 | 0.144 | 0 |
| RC3H2_ENST00000357244 | RC3H2 | Q9HBD1 | Roquin-2 | chr9 | GO:0050852 | Not Cancer Driver | No | 128 | 0.107 | 703 | 81 | 0.115 | 0 |
| RFTN1 | RFTN1 | Q14699 | Raftlin | chr3 | GO:0050852 | Not Cancer Driver | No | 87 | 0.151 | 319 | 44 | 0.138 | 0 |
| RIPK2 | RIPK2 | O43353 | Receptor-interacting serine/threonine-protein kinase 2 | chr8 | GO:0050852 | Not Cancer Driver | No | 63 | 0.117 | 143 | 20 | 0.14 | 0 |
| RNF31 | RNF31 | Q96EP0 | E3 ubiquitin-protein ligase RNF31 | chr14 | GO:0050852 | Not Cancer Driver | No | 142 | 0.132 | 319 | 45 | 0.141 | 0 |
| SKAP1_ENST00000584924 | SKAP1 | Q86WV1 | Src kinase-associated phosphoprotein 1 | chr17 | GO:0050852 | Not Cancer Driver | No | 67 | 0.187 | 130 | 27 | 0.208 | 0 |
| SPPL3 | SPPL3 | Q8TCT6 | Signal peptide peptidase-like 3 | chr12 | GO:0050852 | Not Cancer Driver | No | 45 | 0.117 | 23 | 0 | 0.0 | 0 |
| STK11 | STK11 | Q15831 | Serine/threonine-protein kinase STK11 | chr19 | GO:0050852 | Census, Compendium | Yes | 75 | 0.173 | 135 | 14 | 0.104 | 9 |
| STOML2 | STOML2 | Q9UJZ1 | Stomatin-like protein 2, mitochondrial | chr9 | GO:0050852 | Not Cancer Driver | No | 40 | 0.112 | 117 | 9 | 0.077 | 0 |
| TEC | TEC | P42680 | Tyrosine-protein kinase Tec | chr4 | GO:0050852 | Census, Compendium | Yes | 91 | 0.144 | 57 | 15 | 0.263 | 0 |
| THEMIS2 | THEMIS2 | Q5TEJ8 | Protein THEMIS2 | chr1 | GO:0050852 | Not Cancer Driver | No | 63 | 0.098 | 209 | 21 | 0.1 | 0 |
| THEMIS_ENST00000368250 | THEMIS | Q8N1K5 | Protein THEMIS | chr6 | GO:0050852 | Not Cancer Driver | No | 208 | 0.324 | 111 | 34 | 0.306 | 0 |
| THY1 | THY1 | P04216 | Thy-1 membrane glycoprotein | chr11 | GO:0050852 | Not Cancer Driver | No | 24 | 0.149 | 5 | 0 | 0.0 | 0 |
| TNFRSF21 | TNFRSF21 | O75509 | Tumor necrosis factor receptor superfamily member 21 | chr6 | GO:0050852 | Not Cancer Driver | No | 98 | 0.15 | 280 | 46 | 0.164 | 0 |
| TRAF6_ENST00000348124 | TRAF6 | Q9Y4K3 | TNF receptor-associated factor 6 | chr11 | GO:0050852 | Not Cancer Driver | No | 67 | 0.128 | 62 | 7 | 0.113 | 0 |
| TXK | TXK | P42681 | Tyrosine-protein kinase TXK | chr4 | GO:0050852 | Not Cancer Driver | No | 87 | 0.165 | 61 | 9 | 0.148 | 0 |
| UBE2N | UBE2N | P61088 | Ubiquitin-conjugating enzyme E2 N | chr12 | GO:0050852 | Not Cancer Driver | No | 25 | 0.164 | 24 | 3 | 0.125 | 0 |
| VTCN1 | VTCN1 | Q7Z7D3 | V-set domain-containing T-cell activation inhibitor 1 | chr1 | GO:0050852 | Not Cancer Driver | No | 43 | 0.152 | 3 | 2 | 0.667 | 0 |
| WNK1_ENST00000315939 | WNK1 | Q9H4A3 | Serine/threonine-protein kinase WNK1 | chr12 | GO:0050852 | Not Cancer Driver | No | 278 | 0.117 | 1959 | 223 | 0.114 | 0 |
| ZAP70 | ZAP70 | P43403 | Tyrosine-protein kinase ZAP-70 | chr2 | GO:0050852 | Not Cancer Driver | No | 126 | 0.204 | 117 | 17 | 0.145 | 8 |
| ZC3H12A | ZC3H12A | Q5D1E8 | Endoribonuclease ZC3H12A | chr1 | GO:0050852 | Not Cancer Driver | No | 90 | 0.15 | 396 | 44 | 0.111 | 0 |