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Total number of protein in "GO:0050730" GO term:  132

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
ABI1 ABI1 Q8IZP0 Abl interactor 1 chr10 GO:0050730 Census, Compendium Yes 55 0.108 360 39 0.108 0
ACE ACE P12821 Angiotensin-converting enzyme chr17 GO:0050730 Not Cancer Driver No 201 0.154 86 8 0.093 0
ADAM17 ADAM17 P78536 Disintegrin and metalloproteinase domain-containing protein 17 chr2 GO:0050730 Not Cancer Driver No 80 0.097 182 17 0.093 0
ADORA1 ADORA1 P30542 Adenosine receptor A1 chr1 GO:0050730 Not Cancer Driver No 64 0.196 12 4 0.333 0
ADRA1A_ENST00000380573 ADRA1A P35348 Alpha-1A adrenergic receptor chr8 GO:0050730 Not Cancer Driver No 130 0.279 40 8 0.2 0
ADRA2A ADRA2A P08913 Alpha-2A adrenergic receptor chr10 GO:0050730 Not Cancer Driver No 67 0.144 161 10 0.062 0
AFAP1L2 AFAP1L2 Q8N4X5 Actin filament-associated protein 1-like 2 chr10 GO:0050730 Not Cancer Driver No 86 0.105 558 59 0.106 0
AGT AGT P01019 Angiotensinogen chr1 GO:0050730 Not Cancer Driver No 85 0.179 33 10 0.303 1
ALKAL1 ALKAL1 Q6UXT8 ALK and LTK ligand 1 chr8 GO:0050730 Not Cancer Driver No 18 0.14 49 3 0.061 0
ALKAL2 ALKAL2 Q6UX46 ALK and LTK ligand 2 chr2 GO:0050730 Not Cancer Driver No 7 0.046 31 0 0.0 0
APP APP P05067 Amyloid-beta precursor protein chr21 GO:0050730 Not Cancer Driver No 128 0.166 418 71 0.17 17
AREG AREG P15514 Amphiregulin chr4 GO:0050730 Not Cancer Driver No 28 0.111 149 20 0.134 0
BST1 BST1 Q10588 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 chr4 GO:0050730 Not Cancer Driver No 40 0.126 11 0 0.0 0
BTC BTC P35070 Probetacellulin chr4 GO:0050730 Not Cancer Driver No 29 0.163 12 5 0.417 0
CADM4 CADM4 Q8NFZ8 Cell adhesion molecule 4 chr19 GO:0050730 Not Cancer Driver No 48 0.124 94 9 0.096 0
CASS4 CASS4 Q9NQ75 Cas scaffolding protein family member 4 chr20 GO:0050730 Not Cancer Driver No 204 0.26 496 137 0.276 0
CAV1 CAV1 Q03135 Caveolin-1 chr7 GO:0050730 Not Cancer Driver No 30 0.169 2 0 0.0 0
CBL CBL P22681 E3 ubiquitin-protein ligase CBL chr11 GO:0050730 Census, Compendium Yes 115 0.127 512 56 0.109 4
CBLB CBLB Q13191 E3 ubiquitin-protein ligase CBL-B chr3 GO:0050730 Census Yes 160 0.163 562 104 0.185 0
CBLC_ENST00000647358 CBLC Q9ULV8 E3 ubiquitin-protein ligase CBL-C chr19 GO:0050730 Census Yes 60 0.127 128 21 0.164 0
CD300A CD300A Q9UGN4 CMRF35-like molecule 8 chr17 GO:0050730 Not Cancer Driver No 53 0.177 70 10 0.143 0
CHMP6 CHMP6 Q96FZ7 Charged multivesicular body protein 6 chr17 GO:0050730 Not Cancer Driver No 26 0.129 88 16 0.182 0
CNOT7 CNOT7 Q9UIV1 CCR4-NOT transcription complex subunit 7 chr8 GO:0050730 Not Cancer Driver No 31 0.109 21 1 0.048 0
CSF1R CSF1R P07333 Macrophage colony-stimulating factor 1 receptor chr5 GO:0050730 Census Yes 133 0.137 124 17 0.137 20
DLG3 DLG3 Q92796 Disks large homolog 3 chrX GO:0050730 Not Cancer Driver No 94 0.115 322 30 0.093 0
DLG4_ENST00000399506 DLG4 P78352 Disks large homolog 4 chr17 GO:0050730 Not Cancer Driver No 116 0.16 232 55 0.237 0
DMTN_ENST00000358242 DMTN Q08495 Dematin chr8 GO:0050730 Not Cancer Driver No 53 0.131 348 46 0.132 0
DOCK3 DOCK3 Q8IZD9 Dedicator of cytokinesis protein 3 chr3 GO:0050730 Not Cancer Driver No 365 0.18 458 69 0.151 0
DOK7 DOK7 Q18PE1 Protein Dok-7 chr4 GO:0050730 Not Cancer Driver No 52 0.103 286 27 0.094 19
DUSP22_ENST00000344450 DUSP22 Q9NRW4 Dual specificity protein phosphatase 22 chr6 GO:0050730 Not Cancer Driver No 84 0.457 0 0 0.0 0
DVL2 DVL2 O14641 Segment polarity protein dishevelled homolog DVL-2 chr17 GO:0050730 Not Cancer Driver No 96 0.13 514 64 0.125 0
EFNA1 EFNA1 P20827 Ephrin-A1 chr1 GO:0050730 Not Cancer Driver No 29 0.141 46 5 0.109 0
EGF EGF P01133 Pro-epidermal growth factor chr4 GO:0050730 Not Cancer Driver No 184 0.152 191 25 0.131 1
EGFR EGFR P00533 Epidermal growth factor receptor chr7 GO:0050730 Census, Compendium Yes 444 0.367 223 35 0.157 1
EPGN EPGN Q6UW88 Epigen chr4 GO:0050730 Not Cancer Driver No 16 0.104 0 0 0.0 0
EPHA4_ENST00000409938 EPHA4 P54764 Ephrin type-A receptor 4 chr2 GO:0050730 Not Cancer Driver No 182 0.185 140 24 0.171 0
EPHA7 EPHA7 Q15375 Ephrin type-A receptor 7 chr6 GO:0050730 Census, Compendium Yes 280 0.281 71 15 0.211 0
ERBB3 ERBB3 P21860 Receptor tyrosine-protein kinase erbB-3 chr12 GO:0050730 Census, Compendium Yes 298 0.222 396 70 0.177 3
ERCC6 ERCC6 Q03468 DNA excision repair protein ERCC-6 chr10 GO:0050730 Not Cancer Driver No 211 0.141 829 117 0.141 9
EREG EREG O14944 Proepiregulin chr4 GO:0050730 Not Cancer Driver No 26 0.154 10 3 0.3 0
ERRFI1 ERRFI1 Q9UJM3 ERBB receptor feedback inhibitor 1 chr1 GO:0050730 Not Cancer Driver No 55 0.119 297 37 0.125 0
FBXW7_ENST00000603841 FBXW7 Q969H0 F-box/WD repeat-containing protein 7 chr4 GO:0050730 Census, Compendium Yes 322 0.455 230 38 0.165 0
FCGR1A FCGR1A P12314 High affinity immunoglobulin gamma Fc receptor I chr1 GO:0050730 Not Cancer Driver No 62 0.166 37 5 0.135 0
FGFR1OP CEP43 O95684 Centrosomal protein 43 chr6 GO:0050730 Not Cancer Driver No 43 0.108 272 33 0.121 0
FYN FYN P06241 Tyrosine-protein kinase Fyn chr6 GO:0050730 Not Cancer Driver No 92 0.171 70 13 0.186 0
GAS6 GAS6 Q14393 Growth arrest-specific protein 6 chr13 GO:0050730 Not Cancer Driver No 82 0.121 42 6 0.143 0
GH1 GH1 P01241 Somatotropin chr17 GO:0050730 Not Cancer Driver No 54 0.249 24 9 0.375 15
GHRL_ENST00000457360 GHRL Q9UBU3 Appetite-regulating hormone chr3 GO:0050730 Not Cancer Driver No 20 0.171 52 11 0.212 0
GPRC5A GPRC5A Q8NFJ5 Retinoic acid-induced protein 3 chr12 GO:0050730 Not Cancer Driver No 43 0.12 19 4 0.211 0
GPRC5B_ENST00000569479 GPRC5B Q9NZH0 G-protein coupled receptor family C group 5 member B chr16 GO:0050730 Not Cancer Driver No 82 0.203 75 19 0.253 0
GREM1 GREM1 O60565 Gremlin-1 chr15 GO:0050730 Not Cancer Driver No 25 0.136 77 12 0.156 0
GRM5 GRM5 P41594 Metabotropic glutamate receptor 5 chr11 GO:0050730 Not Cancer Driver No 312 0.257 323 51 0.158 0
HBEGF HBEGF Q99075 Proheparin-binding EGF-like growth factor chr5 GO:0050730 Not Cancer Driver No 16 0.077 63 3 0.048 0
HRG HRG P04196 Histidine-rich glycoprotein chr3 GO:0050730 Not Cancer Driver No 121 0.23 277 75 0.271 2
HYAL2_ENST00000357750 HYAL2 Q12891 Hyaluronidase-2 chr3 GO:0050730 Not Cancer Driver No 52 0.11 8 1 0.125 0
IBTK IBTK Q9P2D0 Inhibitor of Bruton tyrosine kinase chr6 GO:0050730 Not Cancer Driver No 146 0.108 364 39 0.107 0
IL12B IL12B P29460 Interleukin-12 subunit beta chr5 GO:0050730 Not Cancer Driver No 48 0.146 42 2 0.048 0
IL22RA2 IL22RA2 Q969J5 Interleukin-22 receptor subunit alpha-2 chr6 GO:0050730 Not Cancer Driver No 35 0.133 14 3 0.214 0
IL23A IL23A Q9NPF7 Interleukin-23 subunit alpha chr12 GO:0050730 Not Cancer Driver No 15 0.079 42 3 0.071 0
IL23R IL23R Q5VWK5 Interleukin-23 receptor chr1 GO:0050730 Not Cancer Driver No 70 0.111 117 19 0.162 0
IL34 IL34 Q6ZMJ4 Interleukin-34 chr16 GO:0050730 Not Cancer Driver No 22 0.091 42 6 0.143 0
IL6R IL6R P08887 Interleukin-6 receptor subunit alpha chr1 GO:0050730 Not Cancer Driver No 55 0.118 165 23 0.139 1
IL7 IL7 P13232 Interleukin-7 chr8 GO:0050730 Not Cancer Driver No 29 0.164 19 4 0.211 0
IL9 IL9 P15248 Interleukin-9 chr5 GO:0050730 Not Cancer Driver No 12 0.083 4 0 0.0 0
INPP5F INPP5F Q9Y2H2 Phosphatidylinositide phosphatase SAC2 chr10 GO:0050730 Not Cancer Driver No 138 0.122 394 45 0.114 0
ITGB2_ENST00000355153 ITGB2 P05107 Integrin beta-2 chr21 GO:0050730 Not Cancer Driver No 147 0.191 59 9 0.153 15
LILRA5 LILRA5 A6NI73 Leukocyte immunoglobulin-like receptor subfamily A member 5 chr19 GO:0050730 Not Cancer Driver No 79 0.264 98 19 0.194 0
LILRB4 LILRB4 Q8NHJ6 Leukocyte immunoglobulin-like receptor subfamily B member 4 chr19 GO:0050730 Not Cancer Driver No 162 0.362 277 115 0.415 0
LRP8 LRP8 Q14114 Low-density lipoprotein receptor-related protein 8 chr1 GO:0050730 Not Cancer Driver No 94 0.098 190 24 0.126 0
LRRK1 LRRK1 Q38SD2 Leucine-rich repeat serine/threonine-protein kinase 1 chr15 GO:0050730 Not Cancer Driver No 289 0.143 261 33 0.126 0
MVP MVP Q14764 Major vault protein chr16 GO:0050730 Not Cancer Driver No 141 0.158 285 31 0.109 0
NCAPG2_ENST00000356309 NCAPG2 Q86XI2 Condensin-2 complex subunit G2 chr7 GO:0050730 Not Cancer Driver No 113 0.099 72 8 0.111 3
NCF1 NCF1 P14598 Neutrophil cytosol factor 1 chr7 GO:0050730 Not Cancer Driver No 37 0.095 181 12 0.066 1
NCK2_ENST00000393349 NCK2 O43639 Cytoplasmic protein NCK2 chr2 GO:0050730 Not Cancer Driver No 89 0.234 88 19 0.216 0
NEDD9 NEDD9 Q14511 Enhancer of filamentation 1 chr6 GO:0050730 Not Cancer Driver No 106 0.127 516 72 0.14 0
NEURL1 NEURL1 O76050 E3 ubiquitin-protein ligase NEURL1 chr10 GO:0050730 Not Cancer Driver No 62 0.108 153 11 0.072 0
NF2 NF2 P35240 Merlin chr22 GO:0050730 Census, Compendium Yes 69 0.116 252 26 0.103 16
NOX4 NOX4 Q9NPH5 NADPH oxidase 4 chr11 GO:0050730 Not Cancer Driver No 123 0.213 0 0 0.0 0
NRG1_ENST00000405005 NRG1 Q02297 Pro-neuregulin-1, membrane-bound isoform chr8 GO:0050730 Census, Compendium Yes 159 0.248 528 132 0.25 0
NTF3_ENST00000331010 NTF3 P20783 Neurotrophin-3 chr12 GO:0050730 Not Cancer Driver No 52 0.202 99 21 0.212 0
PAK2 PAK2 Q13177 Serine/threonine-protein kinase PAK 2 chr3 GO:0050730 Compendium Yes 89 0.17 242 49 0.202 0
PARP14 PARP14 Q460N5 Protein mono-ADP-ribosyltransferase PARP14 chr3 GO:0050730 Not Cancer Driver No 221 0.123 301 57 0.189 0
PDCL3 PDCL3 Q9H2J4 Phosducin-like protein 3 chr2 GO:0050730 Not Cancer Driver No 48 0.201 73 13 0.178 0
PDGFA PDGFA P04085 Platelet-derived growth factor subunit A chr7 GO:0050730 Not Cancer Driver No 31 0.147 75 10 0.133 0
PDGFB PDGFB P01127 Platelet-derived growth factor subunit B chr22 GO:0050730 Census Yes 37 0.154 99 22 0.222 2
PDGFC PDGFC Q9NRA1 Platelet-derived growth factor C chr4 GO:0050730 Not Cancer Driver No 86 0.249 53 12 0.226 0
PDGFD PDGFD Q9GZP0 Platelet-derived growth factor D chr11 GO:0050730 Not Cancer Driver No 85 0.23 37 13 0.351 0
PIBF1 PIBF1 Q8WXW3 Progesterone-induced-blocking factor 1 chr13 GO:0050730 Not Cancer Driver No 83 0.11 419 45 0.107 2
PPP2CA PPP2CA P67775 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform chr5 GO:0050730 Not Cancer Driver No 41 0.133 12 1 0.083 8
PPP2R1A PPP2R1A P30153 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform chr19 GO:0050730 Census, Compendium Yes 179 0.304 0 0 0.0 4
PPP2R5B PPP2R5B Q15173 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform chr11 GO:0050730 Not Cancer Driver No 79 0.159 119 9 0.076 0
PRKCD_ENST00000330452 PRKCD Q05655 Protein kinase C delta type chr3 GO:0050730 Compendium Yes 79 0.117 43 9 0.209 0
PRKCE PRKCE Q02156 Protein kinase C epsilon type chr2 GO:0050730 Not Cancer Driver No 107 0.145 170 26 0.153 0
PRKCZ PRKCZ Q05513 Protein kinase C zeta type chr1 GO:0050730 Not Cancer Driver No 70 0.118 116 11 0.095 0
PRNP PRNP P04156 Major prion protein chr20 GO:0050730 Not Cancer Driver No 36 0.142 115 7 0.061 18
PSEN1 PSEN1 P49768 Presenilin-1 chr14 GO:0050730 Not Cancer Driver No 61 0.131 134 21 0.157 96
PTK6 PTK6 Q13882 Protein-tyrosine kinase 6 chr20 GO:0050730 Census Yes 42 0.093 12 0 0.0 0
PTPN1 PTPN1 P18031 Tyrosine-protein phosphatase non-receptor type 1 chr20 GO:0050730 Not Cancer Driver No 49 0.113 140 25 0.179 0
PTPN2 PTPN2 P17706 Tyrosine-protein phosphatase non-receptor type 2 chr18 GO:0050730 Not Cancer Driver No 57 0.137 120 14 0.117 0
PTPN6_ENST00000318974 PTPN6 P29350 Tyrosine-protein phosphatase non-receptor type 6 chr12 GO:0050730 Census, Compendium Yes 73 0.123 192 25 0.13 0
PTPRC PTPRC P08575 Receptor-type tyrosine-protein phosphatase C chr1 GO:0050730 Census, Compendium Yes 315 0.241 462 107 0.232 0
RACK1 RACK1 P63244 Receptor of activated protein C kinase 1 chr5 GO:0050730 Not Cancer Driver No 34 0.107 13 0 0.0 0
RAP2B RAP2B P61225 Ras-related protein Rap-2b chr3 GO:0050730 Not Cancer Driver No 22 0.12 0 0 0.0 0
RAP2C_ENST00000370874 RAP2C Q9Y3L5 Ras-related protein Rap-2c chrX GO:0050730 Not Cancer Driver No 32 0.175 8 2 0.25 0
RELN RELN P78509 Reelin chr7 GO:0050730 Not Cancer Driver No 761 0.22 107 19 0.178 7
SAMSN1_ENST00000400566 SAMSN1 Q9NSI8 SAM domain-containing protein SAMSN-1 chr21 GO:0050730 Not Cancer Driver No 112 0.3 291 85 0.292 0
SEMA4D SEMA4D Q92854 Semaphorin-4D chr9 GO:0050730 Not Cancer Driver No 117 0.136 132 15 0.114 0
SFRP1 SFRP1 Q8N474 Secreted frizzled-related protein 1 chr8 GO:0050730 Not Cancer Driver No 40 0.127 39 7 0.179 0
SFRP2 SFRP2 Q96HF1 Secreted frizzled-related protein 2 chr4 GO:0050730 Not Cancer Driver No 47 0.159 1 0 0.0 0
SH2B3 SH2B3 Q9UQQ2 SH2B adapter protein 3 chr12 GO:0050730 Census, Compendium Yes 48 0.083 333 19 0.057 0
SH3BP5 SH3BP5 O60239 SH3 domain-binding protein 5 chr3 GO:0050730 Not Cancer Driver No 46 0.101 378 35 0.093 0
SH3BP5L SH3BP5L Q7L8J4 SH3 domain-binding protein 5-like chr1 GO:0050730 Not Cancer Driver No 62 0.158 376 57 0.152 0
SHC1_ENST00000368445 SHC1 P29353 SHC-transforming protein 1 chr1 GO:0050730 Not Cancer Driver No 84 0.144 397 58 0.146 0
SNX6 SNX6 Q9UNH7 Sorting nexin-6 chr14 GO:0050730 Not Cancer Driver No 33 0.081 85 7 0.082 0
SOCS1 SOCS1 O15524 Suppressor of cytokine signaling 1 chr16 GO:0050730 Census, Compendium Yes 22 0.104 66 3 0.045 2
SOCS3 SOCS3 O14543 Suppressor of cytokine signaling 3 chr17 GO:0050730 Not Cancer Driver No 27 0.12 111 14 0.126 0
SOCS4_ENST00000555846 SOCS4 Q8WXH5 Suppressor of cytokine signaling 4 chr14 GO:0050730 Not Cancer Driver No 43 0.098 136 13 0.096 0
SOCS5 SOCS5 O75159 Suppressor of cytokine signaling 5 chr2 GO:0050730 Not Cancer Driver No 84 0.157 297 46 0.155 0
SPINK1 SPINK1 P00995 Serine protease inhibitor Kazal-type 1 chr5 GO:0050730 Not Cancer Driver No 14 0.177 0 0 0.0 3
SRC_ENST00000358208 SRC P12931 Proto-oncogene tyrosine-protein kinase Src chr20 GO:0050730 Census Yes 53 0.099 130 11 0.085 1
STAP1_ENST00000396225 STAP1 Q9ULZ2 Signal-transducing adaptor protein 1 chr4 GO:0050730 Not Cancer Driver No 66 0.224 103 18 0.175 0
TGFA_ENST00000295400 TGFA P01135 Protransforming growth factor alpha chr2 GO:0050730 Not Cancer Driver No 20 0.125 0 0 0.0 0
THY1 THY1 P04216 Thy-1 membrane glycoprotein chr11 GO:0050730 Not Cancer Driver No 24 0.149 5 0 0.0 0
TMEM102 TMEM102 Q8N9M5 Transmembrane protein 102 chr17 GO:0050730 Not Cancer Driver No 38 0.075 141 13 0.092 0
TREM2 TREM2 Q9NZC2 Triggering receptor expressed on myeloid cells 2 chr6 GO:0050730 Not Cancer Driver No 43 0.187 27 2 0.074 1
TSG101 TSG101 Q99816 Tumor susceptibility gene 101 protein chr11 GO:0050730 Not Cancer Driver No 46 0.118 159 23 0.145 0
UNC119 UNC119 Q13432 Protein unc-119 homolog A chr17 GO:0050730 Not Cancer Driver No 20 0.083 89 4 0.045 1
VEGFA_ENST00000523873 VEGFA P15692 Vascular endothelial growth factor A chr6 GO:0050730 Not Cancer Driver No 27 0.116 41 7 0.171 0
VPS25 VPS25 Q9BRG1 Vacuolar protein-sorting-associated protein 25 chr17 GO:0050730 Not Cancer Driver No 16 0.091 10 0 0.0 0
WNT3A WNT3A P56704 Protein Wnt-3a chr1 GO:0050730 Not Cancer Driver No 77 0.219 37 5 0.135 0
ZFYVE28 ZFYVE28 Q9HCC9 Lateral signaling target protein 2 homolog chr4 GO:0050730 Not Cancer Driver No 132 0.149 420 67 0.16 0
ZGPAT ZGPAT Q8N5A5 Zinc finger CCCH-type with G patch domain-containing protein chr20 GO:0050730 Not Cancer Driver No 75 0.141 346 49 0.142 0