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Total number of protein in "GO:0048568" GO term:  143

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
A2M A2M P01023 Alpha-2-macroglobulin chr12 GO:0048568 Not Cancer Driver No 260 0.176 144 22 0.153 0
ADA ADA P00813 Adenosine deaminase chr20 GO:0048568 Not Cancer Driver No 50 0.138 44 9 0.205 27
AKT1_ENST00000349310 AKT1 P31749 RAC-alpha serine/threonine-protein kinase chr14 GO:0048568 Census, Compendium Yes 108 0.225 158 24 0.152 4
ALDH1A2 ALDH1A2 O94788 Retinal dehydrogenase 2 chr15 GO:0048568 Not Cancer Driver No 100 0.193 56 13 0.232 0
ALDH1A3 ALDH1A3 P47895 Aldehyde dehydrogenase family 1 member A3 chr15 GO:0048568 Not Cancer Driver No 74 0.145 73 7 0.096 10
ARID2 ARID2 Q68CP9 AT-rich interactive domain-containing protein 2 chr12 GO:0048568 Census, Compendium Yes 272 0.148 1143 141 0.123 0
ARNT ARNT P27540 Aryl hydrocarbon receptor nuclear translocator chr1 GO:0048568 Census Yes 77 0.098 511 56 0.11 0
ATF4_ENST00000404241 ATF4 P18848 Cyclic AMP-dependent transcription factor ATF-4 chr22 GO:0048568 Not Cancer Driver No 53 0.151 259 38 0.147 0
BLOC1S2 BLOC1S2 Q6QNY1 Biogenesis of lysosome-related organelles complex 1 subunit 2 chr10 GO:0048568 Not Cancer Driver No 17 0.12 34 6 0.176 0
BMPR1A BMPR1A P36894 Bone morphogenetic protein receptor type-1A chr10 GO:0048568 Census, Compendium Yes 66 0.124 21 0 0.0 8
BPTF_ENST00000321892 BPTF Q12830 Nucleosome-remodeling factor subunit BPTF chr17 GO:0048568 Not Cancer Driver No 309 0.101 2187 218 0.1 2
CC2D2A CC2D2A Q9P2K1 Coiled-coil and C2 domain-containing protein 2A chr4 GO:0048568 Not Cancer Driver No 165 0.102 676 78 0.115 22
CCDC134 CCDC134 Q9H6E4 Coiled-coil domain-containing protein 134 chr22 GO:0048568 Not Cancer Driver No 24 0.105 43 3 0.07 0
CCN1 CCN1 O00622 CCN family member 1 chr1 GO:0048568 Not Cancer Driver No 33 0.087 12 0 0.0 0
CDC40 CDC40 O60508 Pre-mRNA-processing factor 17 chr6 GO:0048568 Not Cancer Driver No 79 0.136 214 27 0.126 1
CDK20 CDK20 Q8IZL9 Cyclin-dependent kinase 20 chr9 GO:0048568 Not Cancer Driver No 36 0.104 32 1 0.031 0
CEBPA CEBPA P49715 CCAAT/enhancer-binding protein alpha chr19 GO:0048568 Census, Compendium Yes 12 0.034 342 12 0.035 1
CEBPB CEBPB P17676 CCAAT/enhancer-binding protein beta chr20 GO:0048568 Not Cancer Driver No 3 0.009 276 2 0.007 0
CITED2_ENST00000367651 CITED2 Q99967 Cbp/p300-interacting transactivator 2 chr6 GO:0048568 Not Cancer Driver No 23 0.085 230 18 0.078 0
COBL_ENST00000265136 COBL O75128 Protein cordon-bleu chr7 GO:0048568 Not Cancer Driver No 233 0.185 1149 216 0.188 0
COL13A1 COL13A1 Q5TAT6 Collagen alpha-1(XIII) chain chr10 GO:0048568 Not Cancer Driver No 126 0.176 690 126 0.183 0
COL2A1 COL2A1 P02458 Collagen alpha-1(II) chain chr12 GO:0048568 Census Yes 258 0.174 1215 207 0.17 64
CSF2 CSF2 P04141 Granulocyte-macrophage colony-stimulating factor chr5 GO:0048568 Not Cancer Driver No 11 0.076 34 3 0.088 0
CTNNB1_ENST00000643977 CTNNB1 P35222 Catenin beta-1 chr3 GO:0048568 Census, Compendium Yes 415 0.531 288 301 1.045 14
CXCL8 CXCL8 P10145 Interleukin-8 chr4 GO:0048568 Not Cancer Driver No 17 0.172 0 0 0.0 0
EGFR EGFR P00533 Epidermal growth factor receptor chr7 GO:0048568 Census, Compendium Yes 444 0.367 223 35 0.157 1
EN1 EN1 Q05925 Homeobox protein engrailed-1 chr2 GO:0048568 Not Cancer Driver No 42 0.107 357 30 0.084 0
EN2 EN2 P19622 Homeobox protein engrailed-2 chr7 GO:0048568 Not Cancer Driver No 23 0.069 317 23 0.073 0
EPAS1 EPAS1 Q99814 Endothelial PAS domain-containing protein 1 chr2 GO:0048568 Census, Compendium Yes 120 0.138 449 53 0.118 6
EPN1_ENST00000270460 EPN1 Q9Y6I3 Epsin-1 chr19 GO:0048568 Not Cancer Driver No 87 0.151 493 71 0.144 0
ERCC1_ENST00000589165 ERCC1 P07992 DNA excision repair protein ERCC-1 chr19 GO:0048568 Not Cancer Driver No 42 0.141 105 14 0.133 1
ERCC3 ERCC3 P19447 General transcription and DNA repair factor IIH helicase subunit XPB chr2 GO:0048568 Census, Compendium Yes 92 0.118 208 22 0.106 2
ESRRB_ENST00000512784 ESRRB O95718 Steroid hormone receptor ERR2 chr14 GO:0048568 Not Cancer Driver No 90 0.208 35 7 0.2 4
FBXW8 FBXW8 Q8N3Y1 F-box/WD repeat-containing protein 8 chr12 GO:0048568 Not Cancer Driver No 68 0.114 120 4 0.033 0
FGF10 FGF10 O15520 Fibroblast growth factor 10 chr5 GO:0048568 Not Cancer Driver No 56 0.269 34 11 0.324 2
FGF9 FGF9 P31371 Fibroblast growth factor 9 chr13 GO:0048568 Not Cancer Driver No 41 0.197 43 10 0.233 1
FGFR2_ENST00000358487 FGFR2 P21802 Fibroblast growth factor receptor 2 chr10 GO:0048568 Census, Compendium Yes 238 0.29 228 44 0.193 72
FLT3LG_ENST00000600429 FLT3LG P49771 Fms-related tyrosine kinase 3 ligand chr19 GO:0048568 Not Cancer Driver No 27 0.115 39 4 0.103 0
FOXF2 FOXF2 Q12947 Forkhead box protein F2 chr6 GO:0048568 Not Cancer Driver No 44 0.099 277 10 0.036 0
FZD5 FZD5 Q13467 Frizzled-5 chr2 GO:0048568 Not Cancer Driver No 45 0.077 58 4 0.069 0
GATA1 GATA1 P15976 Erythroid transcription factor chrX GO:0048568 Census, Compendium Yes 68 0.165 242 41 0.169 5
GATA2_ENST00000487848 GATA2 P23769 Endothelial transcription factor GATA-2 chr3 GO:0048568 Census, Compendium Yes 72 0.15 370 49 0.132 6
GATA3_ENST00000346208 GATA3 P23771 Trans-acting T-cell-specific transcription factor GATA-3 chr10 GO:0048568 Census, Compendium Yes 111 0.251 364 87 0.239 2
GDF3 GDF3 Q9NR23 Growth/differentiation factor 3 chr12 GO:0048568 Not Cancer Driver No 79 0.217 3 3 1.0 5
GDNF_ENST00000326524 GDNF P39905 Glial cell line-derived neurotrophic factor chr5 GO:0048568 Not Cancer Driver No 47 0.223 83 18 0.217 2
GLI2_ENST00000361492 GLI2 P10070 Zinc finger protein GLI2 chr2 GO:0048568 Not Cancer Driver No 287 0.181 1403 244 0.174 2
GLI3 GLI3 P10071 Transcriptional activator GLI3 chr7 GO:0048568 Not Cancer Driver No 385 0.244 1352 327 0.242 7
HES1 HES1 Q14469 Transcription factor HES-1 chr3 GO:0048568 Not Cancer Driver No 37 0.132 226 32 0.142 0
HEY1_ENST00000354724 HEY1 Q9Y5J3 Hairy/enhancer-of-split related with YRPW motif protein 1 chr8 GO:0048568 Census Yes 33 0.109 172 15 0.087 0
HEY2 HEY2 Q9UBP5 Hairy/enhancer-of-split related with YRPW motif protein 2 chr6 GO:0048568 Not Cancer Driver No 64 0.19 179 26 0.145 0
HIF1A_ENST00000337138 HIF1A Q16665 Hypoxia-inducible factor 1-alpha chr14 GO:0048568 Census Yes 118 0.143 435 51 0.117 0
HOXB7 HOXB7 P09629 Homeobox protein Hox-B7 chr17 GO:0048568 Not Cancer Driver No 25 0.115 84 10 0.119 0
HOXD4 HOXD4 P09016 Homeobox protein Hox-D4 chr2 GO:0048568 Not Cancer Driver No 62 0.243 211 41 0.194 0
HS6ST1 HS6ST1 O60243 Heparan-sulfate 6-O-sulfotransferase 1 chr2 GO:0048568 Not Cancer Driver No 60 0.146 66 14 0.212 6
ID3 ID3 Q02535 DNA-binding protein inhibitor ID-3 chr1 GO:0048568 Census, Compendium Yes 14 0.118 34 4 0.118 0
IFT140 IFT140 Q96RY7 Intraflagellar transport protein 140 homolog chr16 GO:0048568 Not Cancer Driver No 176 0.12 161 27 0.168 10
IGF2_ENST00000641326 IGF2 P01344 Insulin-like growth factor II chr11 GO:0048568 Not Cancer Driver No 39 0.217 44 12 0.273 0
IL3 IL3 P08700 Interleukin-3 chr5 GO:0048568 Not Cancer Driver No 25 0.164 22 3 0.136 0
JUNB JUNB P17275 Transcription factor JunB chr19 GO:0048568 Not Cancer Driver No 20 0.058 305 16 0.052 0
KDR KDR P35968 Vascular endothelial growth factor receptor 2 chr4 GO:0048568 Census, Compendium Yes 357 0.263 275 55 0.2 2
KIT KIT P10721 Mast/stem cell growth factor receptor Kit chr4 GO:0048568 Census, Compendium Yes 226 0.232 83 33 0.398 21
KITLG KITLG P21583 Kit ligand chr12 GO:0048568 Not Cancer Driver No 48 0.176 61 9 0.148 1
KMT2A_ENST00000389506 KMT2A Q03164 Histone-lysine N-methyltransferase 2A chr11 GO:0048568 Census, Compendium Yes 446 0.112 3145 338 0.107 0
MAPK1_ENST00000398822 MAPK1 P28482 Mitogen-activated protein kinase 1 chr22 GO:0048568 Census, Compendium Yes 62 0.172 2 0 0.0 7
MBD2 MBD2 Q9UBB5 Methyl-CpG-binding domain protein 2 chr18 GO:0048568 Not Cancer Driver No 26 0.063 384 25 0.065 0
MBD3 MBD3 O95983 Methyl-CpG-binding domain protein 3 chr19 GO:0048568 Not Cancer Driver No 50 0.172 246 46 0.187 0
MED1 MED1 Q15648 Mediator of RNA polymerase II transcription subunit 1 chr17 GO:0048568 Not Cancer Driver No 162 0.102 1104 117 0.106 0
MED12 MED12 Q93074 Mediator of RNA polymerase II transcription subunit 12 chrX GO:0048568 Census, Compendium Yes 409 0.188 974 175 0.18 5
MFSD2A MFSD2A Q8NA29 Sodium-dependent lysophosphatidylcholine symporter 1 chr1 GO:0048568 Not Cancer Driver No 61 0.112 36 4 0.111 7
MKS1 MKS1 Q9NXB0 Meckel syndrome type 1 protein chr17 GO:0048568 Not Cancer Driver No 82 0.147 152 23 0.151 2
NES NES P48681 Nestin chr1 GO:0048568 Not Cancer Driver No 271 0.167 1474 253 0.172 0
NODAL NODAL Q96S42 Nodal homolog chr10 GO:0048568 Not Cancer Driver No 40 0.115 34 8 0.235 4
NOTO NOTO A8MTQ0 Homeobox protein notochord chr2 GO:0048568 Not Cancer Driver No 15 0.06 116 6 0.052 0
NSDHL NSDHL Q15738 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating chrX GO:0048568 Not Cancer Driver No 60 0.161 39 6 0.154 3
OVOL2 OVOL2 Q9BRP0 Transcription factor Ovo-like 2 chr20 GO:0048568 Not Cancer Driver No 29 0.105 139 8 0.058 0
PALB2 PALB2 Q86YC2 Partner and localizer of BRCA2 chr16 GO:0048568 Census Yes 124 0.105 769 77 0.1 1
PBX1 PBX1 P40424 Pre-B-cell leukemia transcription factor 1 chr1 GO:0048568 Census Yes 82 0.191 290 57 0.197 0
PBX2 PBX2 P40425 Pre-B-cell leukemia transcription factor 2 chr6 GO:0048568 Not Cancer Driver No 57 0.133 297 43 0.145 0
PBX3 PBX3 P40426 Pre-B-cell leukemia transcription factor 3 chr9 GO:0048568 Not Cancer Driver No 59 0.136 290 40 0.138 0
PBX4 PBX4 Q9BYU1 Pre-B-cell leukemia transcription factor 4 chr19 GO:0048568 Not Cancer Driver No 47 0.126 262 26 0.099 0
PCSK5 PCSK5 Q92824 Proprotein convertase subtilisin/kexin type 5 chr9 GO:0048568 Not Cancer Driver No 319 0.172 168 25 0.149 0
PDGFA PDGFA P04085 Platelet-derived growth factor subunit A chr7 GO:0048568 Not Cancer Driver No 31 0.147 75 10 0.133 0
PDGFB PDGFB P01127 Platelet-derived growth factor subunit B chr22 GO:0048568 Census Yes 37 0.154 99 22 0.222 2
PDGFC PDGFC Q9NRA1 Platelet-derived growth factor C chr4 GO:0048568 Not Cancer Driver No 86 0.249 53 12 0.226 0
PKD1 PKD1 P98161 Polycystin-1 chr16 GO:0048568 Not Cancer Driver No 393 0.091 690 66 0.096 92
PKD2 PKD2 Q13563 Polycystin-2 chr4 GO:0048568 Not Cancer Driver No 113 0.117 375 35 0.093 10
PKDCC PKDCC Q504Y2 Extracellular tyrosine-protein kinase PKDCC chr2 GO:0048568 Not Cancer Driver No 36 0.073 124 0 0.0 0
PLCD3 PLCD3 Q8N3E9 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 chr17 GO:0048568 Not Cancer Driver No 61 0.077 229 22 0.096 0
PLG PLG P00747 Plasminogen chr6 GO:0048568 Not Cancer Driver No 242 0.299 230 64 0.278 9
POLE POLE Q07864 DNA polymerase epsilon catalytic subunit A chr12 GO:0048568 Census, Compendium Yes 409 0.179 239 44 0.184 3
PPIL1 PPIL1 Q9Y3C6 Peptidyl-prolyl cis-trans isomerase-like 1 chr6 GO:0048568 Not Cancer Driver No 25 0.151 42 11 0.262 3
PPP1R13L_ENST00000360957 PPP1R13L Q8WUF5 RelA-associated inhibitor chr19 GO:0048568 Not Cancer Driver No 117 0.141 657 90 0.137 0
PTCH1 PTCH1 Q13635 Protein patched homolog 1 chr9 GO:0048568 Census, Compendium Yes 243 0.168 382 67 0.175 18
RARA RARA P10276 Retinoic acid receptor alpha chr17 GO:0048568 Census, Compendium Yes 70 0.152 167 14 0.084 0
RARG RARG P13631 Retinoic acid receptor gamma chr12 GO:0048568 Not Cancer Driver No 82 0.181 164 24 0.146 0
RARRES2 RARRES2 Q99969 Retinoic acid receptor responder protein 2 chr7 GO:0048568 Not Cancer Driver No 16 0.098 14 2 0.143 0
RBBP6 RBBP6 Q7Z6E9 E3 ubiquitin-protein ligase RBBP6 chr16 GO:0048568 Not Cancer Driver No 229 0.128 1626 212 0.13 0
RBPJ_ENST00000361572 RBPJ Q06330 Recombining binding protein suppressor of hairless chr4 GO:0048568 Not Cancer Driver No 49 0.098 151 19 0.126 2
RDH10 RDH10 Q8IZV5 Retinol dehydrogenase 10 chr8 GO:0048568 Not Cancer Driver No 33 0.097 8 0 0.0 0
RNF112 RNF112 Q9ULX5 RING finger protein 112 chr17 GO:0048568 Not Cancer Driver No 86 0.136 168 26 0.155 0
RPL10_ENST00000369817 RPL10 P27635 60S ribosomal protein L10 chrX GO:0048568 Census, Compendium Yes 46 0.215 9 3 0.333 4
SALL1 SALL1 Q9NSC2 Sal-like protein 1 chr16 GO:0048568 Not Cancer Driver No 454 0.343 949 334 0.352 0
SCT SCT P09683 Secretin chr11 GO:0048568 Not Cancer Driver No 4 0.033 71 3 0.042 0
SH2B3 SH2B3 Q9UQQ2 SH2B adapter protein 3 chr12 GO:0048568 Census, Compendium Yes 48 0.083 333 19 0.057 0
SOX9 SOX9 P48436 Transcription factor SOX-9 chr17 GO:0048568 Compendium Yes 86 0.169 495 82 0.166 18
SP3 SP3 Q02447 Transcription factor Sp3 chr2 GO:0048568 Not Cancer Driver No 66 0.085 587 37 0.063 0
STIL_ENST00000360380 STIL Q15468 SCL-interrupting locus protein chr1 GO:0048568 Census, Compendium Yes 147 0.114 735 85 0.116 1
STK3_ENST00000419617 STK3 Q13188 Serine/threonine-protein kinase 3 chr8 GO:0048568 Not Cancer Driver No 70 0.143 241 32 0.133 0
STK4 STK4 Q13043 Serine/threonine-protein kinase 4 chr20 GO:0048568 Not Cancer Driver No 70 0.144 231 30 0.13 0
STRA6_ENST00000323940 STRA6 Q9BX79 Receptor for retinol uptake STRA6 chr15 GO:0048568 Not Cancer Driver No 77 0.115 84 14 0.167 6
SYF2 SYF2 O95926 Pre-mRNA-splicing factor SYF2 chr1 GO:0048568 Not Cancer Driver No 26 0.107 173 17 0.098 0
TAL1 TAL1 P17542 T-cell acute lymphocytic leukemia protein 1 chr1 GO:0048568 Census Yes 54 0.163 305 53 0.174 0
TBC1D23 TBC1D23 Q9NUY8 TBC1 domain family member 23 chr3 GO:0048568 Not Cancer Driver No 75 0.107 147 19 0.129 0
TBX4_ENST00000240335 TBX4 P57082 T-box transcription factor TBX4 chr17 GO:0048568 Not Cancer Driver No 99 0.182 318 69 0.217 2
TEAD1_ENST00000638666 TEAD1 P28347 Transcriptional enhancer factor TEF-1 chr11 GO:0048568 Not Cancer Driver No 52 0.122 157 24 0.153 1
TEAD2_ENST00000311227 TEAD2 Q15562 Transcriptional enhancer factor TEF-4 chr19 GO:0048568 Not Cancer Driver No 66 0.148 220 31 0.141 0
TEAD3_ENST00000639578 TEAD3 Q99594 Transcriptional enhancer factor TEF-5 chr6 GO:0048568 Not Cancer Driver No 40 0.092 120 7 0.058 0
TEAD4 TEAD4 Q15561 Transcriptional enhancer factor TEF-3 chr12 GO:0048568 Not Cancer Driver No 72 0.166 171 34 0.199 0
TFEB_ENST00000403298 TFEB P19484 Transcription factor EB chr6 GO:0048568 Census Yes 58 0.122 429 47 0.11 0
TGFB1 TGFB1 P01137 Transforming growth factor beta-1 proprotein chr19 GO:0048568 Not Cancer Driver No 41 0.105 41 4 0.098 10
TGFB2_ENST00000366930 TGFB2 P61812 Transforming growth factor beta-2 proprotein chr1 GO:0048568 Not Cancer Driver No 63 0.152 47 8 0.17 3
TGFBR2_ENST00000295754 TGFBR2 P37173 TGF-beta receptor type-2 chr3 GO:0048568 Census, Compendium Yes 106 0.187 60 16 0.267 25
THOC5_ENST00000397872 THOC5 Q13769 THO complex subunit 5 homolog chr22 GO:0048568 Not Cancer Driver No 88 0.129 173 25 0.145 0
TMED2 TMED2 Q15363 Transmembrane emp24 domain-containing protein 2 chr12 GO:0048568 Not Cancer Driver No 24 0.119 25 4 0.16 0
TNF TNF P01375 Tumor necrosis factor chr6 GO:0048568 Not Cancer Driver No 24 0.103 45 3 0.067 0
TP53_ENST00000445888 TP53 P04637 Cellular tumor antigen p53 chr17 GO:0048568 Census, Compendium Yes 2891 7.356 282 1466 5.199 83
TPO TPO P07202 Thyroid peroxidase chr2 GO:0048568 Not Cancer Driver No 326 0.349 163 69 0.423 24
TRA2B TRA2B P62995 Transformer-2 protein homolog beta chr3 GO:0048568 Not Cancer Driver No 59 0.205 244 54 0.221 0
TTPA TTPA P49638 Alpha-tocopherol transfer protein chr8 GO:0048568 Not Cancer Driver No 53 0.191 20 1 0.05 7
TUBB2B TUBB2B Q9BVA1 Tubulin beta-2B chain chr6 GO:0048568 Not Cancer Driver No 43 0.097 68 10 0.147 10
TULP3_ENST00000448120 TULP3 O75386 Tubby-related protein 3 chr12 GO:0048568 Not Cancer Driver No 66 0.149 218 29 0.133 0
UTP25 UTP25 Q68CQ4 U3 small nucleolar RNA-associated protein 25 homolog chr1 GO:0048568 Not Cancer Driver No 116 0.153 277 28 0.101 0
VASH1 VASH1 Q7L8A9 Tubulinyl-Tyr carboxypeptidase 1 chr14 GO:0048568 Not Cancer Driver No 39 0.107 215 18 0.084 0
VASH2 VASH2 Q86V25 Tubulinyl-Tyr carboxypeptidase 2 chr1 GO:0048568 Not Cancer Driver No 32 0.09 106 9 0.085 0
VPS52 VPS52 Q8N1B4 Vacuolar protein sorting-associated protein 52 homolog chr6 GO:0048568 Not Cancer Driver No 89 0.123 36 5 0.139 0
WDR19 WDR19 Q8NEZ3 WD repeat-containing protein 19 chr4 GO:0048568 Not Cancer Driver No 117 0.087 19 0 0.0 11
WDR48 WDR48 Q8TAF3 WD repeat-containing protein 48 chr3 GO:0048568 Not Cancer Driver No 61 0.09 125 19 0.152 0
WNT1 WNT1 P04628 Proto-oncogene Wnt-1 chr12 GO:0048568 Not Cancer Driver No 29 0.078 25 0 0.0 8
WNT2 WNT2 P09544 Protein Wnt-2 chr7 GO:0048568 Not Cancer Driver No 85 0.236 11 3 0.273 0
WNT7B WNT7B P56706 Protein Wnt-7b chr22 GO:0048568 Not Cancer Driver No 55 0.158 11 1 0.091 0
YAP1_ENST00000282441 YAP1 P46937 Transcriptional coactivator YAP1 chr11 GO:0048568 Not Cancer Driver No 51 0.101 489 49 0.1 0
ZFPM1 ZFPM1 Q8IX07 Zinc finger protein ZFPM1 chr16 GO:0048568 Not Cancer Driver No 50 0.05 772 27 0.035 0
ZFPM2 ZFPM2 Q8WW38 Zinc finger protein ZFPM2 chr8 GO:0048568 Not Cancer Driver No 374 0.325 659 233 0.354 8