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Total number of protein in "GO:0046578" GO term:  120

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
ABCA1 ABCA1 O95477 Phospholipid-transporting ATPase ABCA1 chr9 GO:0046578 Not Cancer Driver No 284 0.126 245 40 0.163 31
ABL1_ENST00000318560 ABL1 P00519 Tyrosine-protein kinase ABL1 chr9 GO:0046578 Census, Compendium Yes 139 0.123 604 73 0.121 2
ABL2 ABL2 P42684 Tyrosine-protein kinase ABL2 chr1 GO:0046578 Census, Compendium Yes 171 0.145 641 70 0.109 0
ABRA ABRA Q8N0Z2 Actin-binding Rho-activating protein chr8 GO:0046578 Not Cancer Driver No 108 0.283 285 86 0.302 0
ADGRG1 ADGRG1 Q9Y653 Adhesion G-protein coupled receptor G1 chr16 GO:0046578 Not Cancer Driver No 64 0.092 67 4 0.06 9
ADRA1A_ENST00000380573 ADRA1A P35348 Alpha-1A adrenergic receptor chr8 GO:0046578 Not Cancer Driver No 130 0.279 40 8 0.2 0
AKAP13_ENST00000394518 AKAP13 Q12802 A-kinase anchor protein 13 chr15 GO:0046578 Not Cancer Driver No 359 0.128 2091 258 0.123 0
ALS2 ALS2 Q96Q42 Alsin chr2 GO:0046578 Not Cancer Driver No 194 0.117 353 36 0.102 0
APOA1_ENST00000375320 APOA1 P02647 Apolipoprotein A-I chr11 GO:0046578 Not Cancer Driver No 28 0.105 131 8 0.061 3
APOC3 APOC3 P02656 Apolipoprotein C-III chr11 GO:0046578 Not Cancer Driver No 14 0.141 12 2 0.167 1
APOE APOE P02649 Apolipoprotein E chr19 GO:0046578 Not Cancer Driver No 25 0.079 124 6 0.048 12
ARF6 ARF6 P62330 ADP-ribosylation factor 6 chr14 GO:0046578 Not Cancer Driver No 18 0.103 5 0 0.0 0
ARFGAP1_ENST00000370283 ARFGAP1 Q8N6T3 ADP-ribosylation factor GTPase-activating protein 1 chr20 GO:0046578 Not Cancer Driver No 60 0.148 264 37 0.14 0
ARFGEF1 ARFGEF1 Q9Y6D6 Brefeldin A-inhibited guanine nucleotide-exchange protein 1 chr8 GO:0046578 Not Cancer Driver No 243 0.131 456 54 0.118 0
ARFGEF2 ARFGEF2 Q9Y6D5 Brefeldin A-inhibited guanine nucleotide-exchange protein 2 chr20 GO:0046578 Not Cancer Driver No 254 0.142 358 63 0.176 0
ARFGEF3 ARFGEF3 Q5TH69 Brefeldin A-inhibited guanine nucleotide-exchange protein 3 chr6 GO:0046578 Not Cancer Driver No 258 0.119 584 58 0.099 0
ARHGAP17 ARHGAP17 Q68EM7 Rho GTPase-activating protein 17 chr16 GO:0046578 Not Cancer Driver No 123 0.14 547 72 0.132 0
ARHGAP24 ARHGAP24 Q8N264 Rho GTPase-activating protein 24 chr4 GO:0046578 Not Cancer Driver No 103 0.138 482 67 0.139 0
ARHGAP35_ENST00000614079 ARHGAP35 Q9NRY4 Rho GTPase-activating protein 35 chr19 GO:0046578 Census, Compendium Yes 255 0.17 409 58 0.142 0
ARHGAP42 ARHGAP42 A6NI28 Rho GTPase-activating protein 42 chr11 GO:0046578 Not Cancer Driver No 63 0.072 311 17 0.055 0
ARHGAP44 ARHGAP44 Q17R89 Rho GTPase-activating protein 44 chr17 GO:0046578 Not Cancer Driver No 126 0.154 424 67 0.158 0
ARHGEF3_ENST00000296315 ARHGEF3 Q9NR81 Rho guanine nucleotide exchange factor 3 chr3 GO:0046578 Not Cancer Driver No 70 0.133 154 17 0.11 0
ARRB1 ARRB1 P49407 Beta-arrestin-1 chr11 GO:0046578 Not Cancer Driver No 49 0.117 154 13 0.084 0
AUTS2 AUTS2 Q8WXX7 Autism susceptibility gene 2 protein chr7 GO:0046578 Not Cancer Driver No 219 0.174 1218 213 0.175 0
BCL6_ENST00000232014 BCL6 P41182 B-cell lymphoma 6 protein chr3 GO:0046578 Census, Compendium Yes 134 0.19 328 67 0.204 0
CADM4 CADM4 Q8NFZ8 Cell adhesion molecule 4 chr19 GO:0046578 Not Cancer Driver No 48 0.124 94 9 0.096 0
CBL CBL P22681 E3 ubiquitin-protein ligase CBL chr11 GO:0046578 Census, Compendium Yes 115 0.127 512 56 0.109 4
CCDC125_ENST00000396499 CCDC125 Q86Z20 Coiled-coil domain-containing protein 125 chr5 GO:0046578 Not Cancer Driver No 58 0.114 261 23 0.088 0
COL3A1 COL3A1 P02461 Collagen alpha-1(III) chain chr2 GO:0046578 Census Yes 402 0.274 1182 337 0.285 103
CRK CRK P46108 Adapter molecule crk chr17 GO:0046578 Not Cancer Driver No 30 0.099 197 23 0.117 0
CUL3 CUL3 Q13618 Cullin-3 chr2 GO:0046578 Census, Compendium Yes 123 0.16 167 23 0.138 3
CYTH1_ENST00000446868 CYTH1 Q15438 Cytohesin-1 chr17 GO:0046578 Not Cancer Driver No 59 0.148 93 15 0.161 0
CYTH2_ENST00000641098 CYTH2 Q99418 Cytohesin-2 chr19 GO:0046578 Not Cancer Driver No 55 0.138 93 12 0.129 0
CYTH3_ENST00000396741 CYTH3 O43739 Cytohesin-3 chr7 GO:0046578 Not Cancer Driver No 49 0.122 96 12 0.125 0
CYTH4 CYTH4 Q9UIA0 Cytohesin-4 chr22 GO:0046578 Not Cancer Driver No 70 0.178 52 10 0.192 0
DENND1A DENND1A Q8TEH3 DENN domain-containing protein 1A chr9 GO:0046578 Not Cancer Driver No 117 0.116 589 76 0.129 0
DENND3 DENND3 A2RUS2 DENN domain-containing protein 3 chr8 GO:0046578 Not Cancer Driver No 192 0.16 118 22 0.186 0
DENND4A_ENST00000431932 DENND4A Q7Z401 C-myc promoter-binding protein chr15 GO:0046578 Not Cancer Driver No 199 0.107 570 64 0.112 0
DENND4B DENND4B O75064 DENN domain-containing protein 4B chr1 GO:0046578 Not Cancer Driver No 201 0.134 498 72 0.145 0
DENND4C_ENST00000602925 DENND4C Q5VZ89 DENN domain-containing protein 4C chr9 GO:0046578 Not Cancer Driver No 190 0.1 710 69 0.097 0
DLC1 DLC1 Q96QB1 Rho GTPase-activating protein 7 chr8 GO:0046578 Not Cancer Driver No 331 0.217 922 237 0.257 0
DNM2_ENST00000355667 DNM2 P50570 Dynamin-2 chr19 GO:0046578 Census Yes 138 0.159 270 43 0.159 22
F11R F11R Q9Y624 Junctional adhesion molecule A chr1 GO:0046578 Not Cancer Driver No 47 0.157 72 15 0.208 0
F2R F2R P25116 Proteinase-activated receptor 1 chr5 GO:0046578 Not Cancer Driver No 73 0.172 19 2 0.105 0
F2RL1 F2RL1 P55085 Proteinase-activated receptor 2 chr5 GO:0046578 Not Cancer Driver No 55 0.139 7 2 0.286 0
F2RL2 F2RL2 O00254 Proteinase-activated receptor 3 chr5 GO:0046578 Not Cancer Driver No 54 0.144 0 0 0.0 0
F2RL3 F2RL3 Q96RI0 Proteinase-activated receptor 4 chr19 GO:0046578 Not Cancer Driver No 43 0.112 46 4 0.087 0
FBXO8 FBXO8 Q9NRD0 F-box only protein 8 chr4 GO:0046578 Not Cancer Driver No 46 0.144 25 1 0.04 0
FLCN FLCN Q8NFG4 Folliculin chr17 GO:0046578 Census, Compendium Yes 59 0.102 157 19 0.121 5
FOXM1_ENST00000359843 FOXM1 Q08050 Forkhead box protein M1 chr12 GO:0046578 Not Cancer Driver No 97 0.127 601 73 0.121 0
GABARAP GABARAP O95166 Gamma-aminobutyric acid receptor-associated protein chr17 GO:0046578 Not Cancer Driver No 9 0.077 11 0 0.0 0
GBF1 GBF1 Q92538 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 chr10 GO:0046578 Not Cancer Driver No 216 0.116 669 76 0.114 0
GPR17 GPR17 Q13304 Uracil nucleotide/cysteinyl leukotriene receptor chr2 GO:0046578 Not Cancer Driver No 57 0.155 16 4 0.25 0
GPR174_ENST00000276077 GPR174 Q9BXC1 Probable G-protein coupled receptor 174 chrX GO:0046578 Not Cancer Driver No 115 0.345 0 0 0.0 0
GPR18_ENST00000397470 GPR18 Q14330 N-arachidonyl glycine receptor chr13 GO:0046578 Not Cancer Driver No 36 0.109 0 0 0.0 0
GPR20 GPR20 Q99678 G-protein coupled receptor 20 chr8 GO:0046578 Not Cancer Driver No 77 0.215 44 11 0.25 0
GPR35_ENST00000403859 GPR35 Q9HC97 G-protein coupled receptor 35 chr2 GO:0046578 Not Cancer Driver No 57 0.184 0 0 0.0 0
GPR4 GPR4 P46093 G-protein coupled receptor 4 chr19 GO:0046578 Not Cancer Driver No 57 0.157 44 8 0.182 0
GPR55 GPR55 Q9Y2T6 G-protein coupled receptor 55 chr2 GO:0046578 Not Cancer Driver No 64 0.201 0 0 0.0 0
GPR65 GPR65 Q8IYL9 Psychosine receptor chr14 GO:0046578 Not Cancer Driver No 70 0.208 0 0 0.0 0
HEG1 HEG1 Q9ULI3 Protein HEG homolog 1 chr3 GO:0046578 Not Cancer Driver No 173 0.125 974 135 0.139 0
IQSEC1_ENST00000273221 IQSEC1 Q6DN90 IQ motif and SEC7 domain-containing protein 1 chr3 GO:0046578 Not Cancer Driver No 141 0.146 610 97 0.159 2
IQSEC2_ENST00000396435 IQSEC2 Q5JU85 IQ motif and SEC7 domain-containing protein 2 chrX GO:0046578 Not Cancer Driver No 163 0.11 1139 97 0.085 5
IQSEC3 IQSEC3 Q9UPP2 IQ motif and SEC7 domain-containing protein 3 chr12 GO:0046578 Not Cancer Driver No 166 0.14 682 85 0.125 0
ITGA3 ITGA3 P26006 Integrin alpha-3 chr17 GO:0046578 Not Cancer Driver No 106 0.101 129 18 0.14 3
ITGB1_ENST00000302278 ITGB1 P05556 Integrin beta-1 chr10 GO:0046578 Not Cancer Driver No 103 0.129 84 10 0.119 0
KANK1_ENST00000382303 KANK1 Q14678 KN motif and ankyrin repeat domain-containing protein 1 chr9 GO:0046578 Not Cancer Driver No 183 0.135 804 100 0.124 0
KBTBD6 KBTBD6 Q86V97 Kelch repeat and BTB domain-containing protein 6 chr13 GO:0046578 Not Cancer Driver No 96 0.142 80 12 0.15 0
KBTBD7 KBTBD7 Q8WVZ9 Kelch repeat and BTB domain-containing protein 7 chr13 GO:0046578 Not Cancer Driver No 92 0.135 105 6 0.057 0
KCTD10 KCTD10 Q9H3F6 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 chr12 GO:0046578 Not Cancer Driver No 68 0.217 73 19 0.26 0
KCTD13 KCTD13 Q8WZ19 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 chr16 GO:0046578 Not Cancer Driver No 33 0.1 95 10 0.105 0
KIF14 KIF14 Q15058 Kinesin-like protein KIF14 chr1 GO:0046578 Not Cancer Driver No 222 0.135 774 102 0.132 2
KRAS KRAS P01116 GTPase KRas chr12 GO:0046578 Census, Compendium Yes 788 4.169 7 2 0.286 27
LPAR1_ENST00000358883 LPAR1 Q92633 Lysophosphatidic acid receptor 1 chr9 GO:0046578 Not Cancer Driver No 79 0.217 21 6 0.286 0
LPAR4 LPAR4 Q99677 Lysophosphatidic acid receptor 4 chrX GO:0046578 Compendium Yes 123 0.332 10 3 0.3 0
LPAR6_ENST00000620633 LPAR6 P43657 Lysophosphatidic acid receptor 6 chr13 GO:0046578 Not Cancer Driver No 39 0.113 0 0 0.0 3
MADD MADD Q8WXG6 MAP kinase-activating death domain protein chr11 GO:0046578 Not Cancer Driver No 207 0.126 723 81 0.112 4
MAP4K4_ENST00000347699 MAP4K4 O95819 Mitogen-activated protein kinase kinase kinase kinase 4 chr2 GO:0046578 Not Cancer Driver No 143 0.115 649 55 0.085 0
MAPRE2 MAPRE2 Q15555 Microtubule-associated protein RP/EB family member 2 chr18 GO:0046578 Not Cancer Driver No 50 0.153 176 28 0.159 3
MCF2L_ENST00000375608 MCF2L O15068 Guanine nucleotide exchange factor DBS chr13 GO:0046578 Not Cancer Driver No 173 0.152 410 54 0.132 0
MET_ENST00000397752 MET P08581 Hepatocyte growth factor receptor chr7 GO:0046578 Census, Compendium Yes 226 0.163 62 15 0.242 19
MYOC MYOC Q99972 Myocilin chr1 GO:0046578 Not Cancer Driver No 92 0.183 196 43 0.219 58
NET1 NET1 Q7Z628 Neuroepithelial cell-transforming gene 1 protein chr10 GO:0046578 Not Cancer Driver No 60 0.101 294 37 0.126 0
NF1 NF1 P21359 Neurofibromin chr17 GO:0046578 Census, Compendium Yes 375 0.132 406 47 0.116 85
NRP1 NRP1 O14786 Neuropilin-1 chr10 GO:0046578 Compendium Yes 146 0.158 211 31 0.147 0
NUP62 NUP62 P37198 Nuclear pore glycoprotein p62 chr19 GO:0046578 Not Cancer Driver No 76 0.146 377 56 0.149 1
OGT OGT O15294 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit chrX GO:0046578 Not Cancer Driver No 156 0.149 89 16 0.18 2
P2RY10 P2RY10 O00398 Putative P2Y purinoceptor 10 chrX GO:0046578 Not Cancer Driver No 113 0.333 0 0 0.0 0
P2RY8 P2RY8 Q86VZ1 P2Y purinoceptor 8 chrX GO:0046578 Census, Compendium Yes 126 0.351 23 5 0.217 0
PDGFRB PDGFRB P09619 Platelet-derived growth factor receptor beta chr5 GO:0046578 Census, Compendium Yes 164 0.148 231 44 0.19 7
PIK3CB_ENST00000477593 PIK3CB P42338 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform chr3 GO:0046578 Census, Compendium Yes 150 0.14 42 4 0.095 0
PIK3CG PIK3CG P48736 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform chr7 GO:0046578 Not Cancer Driver No 318 0.289 121 39 0.322 0
PLCE1 PLCE1 Q9P212 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 chr10 GO:0046578 Not Cancer Driver No 367 0.159 780 107 0.137 1
PRAG1_ENST00000622241 PRAG1 Q86YV5 Inactive tyrosine-protein kinase PRAG1 chr8 GO:0046578 Not Cancer Driver No 193 0.137 988 150 0.152 0
PSD PSD A5PKW4 PH and SEC7 domain-containing protein 1 chr10 GO:0046578 Not Cancer Driver No 173 0.169 714 130 0.182 0
PSD2 PSD2 Q9BQI7 PH and SEC7 domain-containing protein 2 chr5 GO:0046578 Not Cancer Driver No 155 0.201 398 87 0.219 0
PSD3_ENST00000440756 PSD3 Q9NYI0 PH and SEC7 domain-containing protein 3 chr8 GO:0046578 Not Cancer Driver No 146 0.139 645 94 0.146 0
PSD4 PSD4 Q8NDX1 PH and SEC7 domain-containing protein 4 chr2 GO:0046578 Not Cancer Driver No 157 0.149 739 103 0.139 0
RABL3 RABL3 Q5HYI8 Rab-like protein 3 chr3 GO:0046578 Not Cancer Driver No 37 0.157 1 0 0.0 1
RAC1_ENST00000348035 RAC1 P63000 Ras-related C3 botulinum toxin substrate 1 chr7 GO:0046578 Census, Compendium Yes 66 0.344 2 1 0.5 6
RALBP1 RALBP1 Q15311 RalA-binding protein 1 chr18 GO:0046578 Not Cancer Driver No 65 0.099 381 46 0.121 0
RALGPS1 RALGPS1 Q5JS13 Ras-specific guanine nucleotide-releasing factor RalGPS1 chr9 GO:0046578 Not Cancer Driver No 62 0.111 219 26 0.119 0
RALGPS2 RALGPS2 Q86X27 Ras-specific guanine nucleotide-releasing factor RalGPS2 chr1 GO:0046578 Not Cancer Driver No 83 0.142 183 23 0.126 0
RASGRF1 RASGRF1 Q13972 Ras-specific guanine nucleotide-releasing factor 1 chr15 GO:0046578 Not Cancer Driver No 226 0.178 332 64 0.193 0
RASIP1 RASIP1 Q5U651 Ras-interacting protein 1 chr19 GO:0046578 Not Cancer Driver No 73 0.076 505 48 0.095 0
RDX_ENST00000343115 RDX P35241 Radixin chr11 GO:0046578 Not Cancer Driver No 71 0.122 297 37 0.125 1
RGL2 RGL2 O15211 Ral guanine nucleotide dissociation stimulator-like 2 chr6 GO:0046578 Not Cancer Driver No 87 0.112 461 51 0.111 0
RIPOR2_ENST00000259698 RIPOR2 Q9Y4F9 Rho family-interacting cell polarization regulator 2 chr6 GO:0046578 Not Cancer Driver No 131 0.123 421 76 0.181 0
RIT2 RIT2 Q99578 GTP-binding protein Rit2 chr18 GO:0046578 Not Cancer Driver No 74 0.341 29 11 0.379 0
ROBO1 ROBO1 Q9Y6N7 Roundabout homolog 1 chr3 GO:0046578 Not Cancer Driver No 353 0.214 1122 234 0.209 0
RTN4R RTN4R Q9BZR6 Reticulon-4 receptor chr22 GO:0046578 Not Cancer Driver No 38 0.08 148 17 0.115 5
SCAI_ENST00000336505 SCAI Q8N9R8 Protein SCAI chr9 GO:0046578 Not Cancer Driver No 95 0.157 117 13 0.111 0
SGSM3 SGSM3 Q96HU1 Small G protein signaling modulator 3 chr22 GO:0046578 Not Cancer Driver No 83 0.111 77 9 0.117 0
SH3BP1 SH3BP1 Q9Y3L3 SH3 domain-binding protein 1 chr22 GO:0046578 Not Cancer Driver No 57 0.081 430 31 0.072 0
SQSTM1 SQSTM1 Q13501 Sequestosome-1 chr5 GO:0046578 Not Cancer Driver No 54 0.123 267 32 0.12 30
SSX2IP SSX2IP Q9Y2D8 Afadin- and alpha-actinin-binding protein chr1 GO:0046578 Not Cancer Driver No 82 0.134 265 31 0.117 0
STMN1_ENST00000357865 STMN1 P16949 Stathmin chr1 GO:0046578 Not Cancer Driver No 15 0.101 149 15 0.101 0
STMN3 STMN3 Q9NZ72 Stathmin-3 chr20 GO:0046578 Not Cancer Driver No 26 0.144 152 25 0.164 0
SYNPO2L SYNPO2L Q9H987 Synaptopodin 2-like protein chr10 GO:0046578 Not Cancer Driver No 103 0.105 950 99 0.104 0
TNFAIP1 TNFAIP1 Q13829 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 chr17 GO:0046578 Not Cancer Driver No 35 0.111 39 5 0.128 0