Total number of protein in "GO:0045861" GO term: 107
| Identifier | UniProt Gene | UniProt Accession | UniProt Name | Chromosome | GO term | Database | Cancer Driver | Number of missense mutations | Missense mutation per residues | Number of disordered residues | Number of mutations in disordered regions | Disordered missense mutations per residues | Number of OMIM mutation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ACP4 | ACP4 | Q9BZG2 | Testicular acid phosphatase | chr19 | GO:0045861 | Not Cancer Driver | No | 66 | 0.155 | 28 | 7 | 0.25 | 3 |
| AKT1_ENST00000349310 | AKT1 | P31749 | RAC-alpha serine/threonine-protein kinase | chr14 | GO:0045861 | Census, Compendium | Yes | 108 | 0.225 | 158 | 24 | 0.152 | 4 |
| ANXA8L1 | ANXA8L1 | Q5VT79 | Annexin A8-like protein 1 | chr10 | GO:0045861 | Not Cancer Driver | No | 5 | 0.015 | 37 | 0 | 0.0 | 0 |
| AQP11 | AQP11 | Q8NBQ7 | Aquaporin-11 | chr11 | GO:0045861 | Not Cancer Driver | No | 23 | 0.085 | 0 | 0 | 0.0 | 0 |
| BAG6 | BAG6 | P46379 | Large proline-rich protein BAG6 | chr6 | GO:0045861 | Not Cancer Driver | No | 98 | 0.087 | 861 | 79 | 0.092 | 0 |
| BCL2L12 | BCL2L12 | Q9HB09 | Bcl-2-like protein 12 | chr19 | GO:0045861 | Census, Compendium | Yes | 40 | 0.12 | 132 | 10 | 0.076 | 0 |
| BIN1 | BIN1 | O00499 | Myc box-dependent-interacting protein 1 | chr2 | GO:0045861 | Not Cancer Driver | No | 65 | 0.11 | 456 | 42 | 0.092 | 5 |
| CAAP1 | CAAP1 | Q9H8G2 | Caspase activity and apoptosis inhibitor 1 | chr9 | GO:0045861 | Not Cancer Driver | No | 28 | 0.078 | 234 | 18 | 0.077 | 0 |
| CARD16 | CARD16 | Q5EG05 | Caspase recruitment domain-containing protein 16 | chr11 | GO:0045861 | Not Cancer Driver | No | 36 | 0.183 | 23 | 7 | 0.304 | 0 |
| CARD18 | CARD18 | P57730 | Caspase recruitment domain-containing protein 18 | chr11 | GO:0045861 | Not Cancer Driver | No | 24 | 0.267 | 14 | 1 | 0.071 | 0 |
| CARD8_ENST00000519940 | CARD8 | Q9Y2G2 | Caspase recruitment domain-containing protein 8 | chr19 | GO:0045861 | Not Cancer Driver | No | 53 | 0.099 | 126 | 7 | 0.056 | 1 |
| CAST_ENST00000395813 | CAST | P20810 | Calpastatin | chr5 | GO:0045861 | Not Cancer Driver | No | 73 | 0.103 | 708 | 73 | 0.103 | 0 |
| CDK5 | CDK5 | Q00535 | Cyclin-dependent kinase 5 | chr7 | GO:0045861 | Not Cancer Driver | No | 48 | 0.164 | 5 | 1 | 0.2 | 0 |
| CHAC1_ENST00000617961 | CHAC1 | Q9BUX1 | Glutathione-specific gamma-glutamylcyclotransferase 1 | chr15 | GO:0045861 | Not Cancer Driver | No | 30 | 0.135 | 49 | 5 | 0.102 | 0 |
| CLN3_ENST00000636147 | CLN3 | Q13286 | Battenin | chr16 | GO:0045861 | Not Cancer Driver | No | 58 | 0.132 | 69 | 10 | 0.145 | 9 |
| CLN8 | CLN8 | Q9UBY8 | Protein CLN8 | chr8 | GO:0045861 | Not Cancer Driver | No | 45 | 0.157 | 16 | 2 | 0.125 | 16 |
| CPB2_ENST00000645658 | CPB2 | Q96IY4 | Carboxypeptidase B2 | chr13 | GO:0045861 | Not Cancer Driver | No | 59 | 0.139 | 2 | 0 | 0.0 | 0 |
| CR1_ENST00000367053 | CR1 | P17927 | Complement receptor type 1 | chr1 | GO:0045861 | Compendium | Yes | 383 | 0.188 | 151 | 42 | 0.278 | 0 |
| CSN2 | CSN2 | P05814 | Beta-casein | chr4 | GO:0045861 | Not Cancer Driver | No | 49 | 0.217 | 41 | 12 | 0.293 | 0 |
| CSNK2A1_ENST00000400217 | CSNK2A1 | P68400 | Casein kinase II subunit alpha | chr20 | GO:0045861 | Not Cancer Driver | No | 71 | 0.182 | 75 | 8 | 0.107 | 4 |
| CSNK2A2 | CSNK2A2 | P19784 | Casein kinase II subunit alpha' | chr16 | GO:0045861 | Not Cancer Driver | No | 43 | 0.123 | 13 | 1 | 0.077 | 0 |
| CST3_ENST00000376925 | CST3 | P01034 | Cystatin-C | chr20 | GO:0045861 | Not Cancer Driver | No | 17 | 0.116 | 31 | 1 | 0.032 | 2 |
| CST4 | CST4 | P01036 | Cystatin-S | chr20 | GO:0045861 | Not Cancer Driver | No | 37 | 0.262 | 2 | 0 | 0.0 | 0 |
| CST7 | CST7 | O76096 | Cystatin-F | chr20 | GO:0045861 | Not Cancer Driver | No | 12 | 0.083 | 15 | 2 | 0.133 | 0 |
| CSTA | CSTA | P01040 | Cystatin-A | chr3 | GO:0045861 | Not Cancer Driver | No | 16 | 0.163 | 54 | 9 | 0.167 | 0 |
| CSTB | CSTB | P04080 | Cystatin-B | chr21 | GO:0045861 | Not Cancer Driver | No | 7 | 0.071 | 40 | 0 | 0.0 | 1 |
| CTSZ | CTSZ | Q9UBR2 | Cathepsin Z | chr20 | GO:0045861 | Not Cancer Driver | No | 30 | 0.099 | 10 | 0 | 0.0 | 0 |
| DNAJC1 | DNAJC1 | Q96KC8 | DnaJ homolog subfamily C member 1 | chr10 | GO:0045861 | Not Cancer Driver | No | 60 | 0.108 | 315 | 44 | 0.14 | 0 |
| F2 | F2 | P00734 | Prothrombin | chr11 | GO:0045861 | Not Cancer Driver | No | 115 | 0.185 | 97 | 25 | 0.258 | 10 |
| GAS1 | GAS1 | P54826 | Growth arrest-specific protein 1 | chr9 | GO:0045861 | Not Cancer Driver | No | 13 | 0.038 | 82 | 4 | 0.049 | 0 |
| GLG1_ENST00000422840 | GLG1 | Q92896 | Golgi apparatus protein 1 | chr16 | GO:0045861 | Not Cancer Driver | No | 134 | 0.114 | 103 | 7 | 0.068 | 0 |
| HDAC6_ENST00000426196 | HDAC6 | Q9UBN7 | Histone deacetylase 6 | chrX | GO:0045861 | Not Cancer Driver | No | 178 | 0.147 | 409 | 59 | 0.144 | 0 |
| HFE | HFE | Q30201 | Hereditary hemochromatosis protein | chr6 | GO:0045861 | Not Cancer Driver | No | 55 | 0.158 | 27 | 2 | 0.074 | 11 |
| HIPK2 | HIPK2 | Q9H2X6 | Homeodomain-interacting protein kinase 2 | chr7 | GO:0045861 | Not Cancer Driver | No | 154 | 0.129 | 686 | 96 | 0.14 | 0 |
| IFI16_ENST00000295809 | IFI16 | Q16666 | Gamma-interferon-inducible protein 16 | chr1 | GO:0045861 | Not Cancer Driver | No | 155 | 0.197 | 419 | 90 | 0.215 | 0 |
| IL10 | IL10 | P22301 | Interleukin-10 | chr1 | GO:0045861 | Not Cancer Driver | No | 19 | 0.107 | 23 | 1 | 0.043 | 0 |
| IL1R2_ENST00000393414 | IL1R2 | P27930 | Interleukin-1 receptor type 2 | chr2 | GO:0045861 | Not Cancer Driver | No | 75 | 0.188 | 32 | 10 | 0.312 | 0 |
| IL9 | IL9 | P15248 | Interleukin-9 | chr5 | GO:0045861 | Not Cancer Driver | No | 12 | 0.083 | 4 | 0 | 0.0 | 0 |
| INS | INS | P01308 | Insulin | chr11 | GO:0045861 | Not Cancer Driver | No | 15 | 0.136 | 5 | 1 | 0.2 | 22 |
| KNG1 | KNG1 | P01042 | Kininogen-1 | chr3 | GO:0045861 | Not Cancer Driver | No | 130 | 0.202 | 294 | 66 | 0.224 | 1 |
| LRIG2 | LRIG2 | O94898 | Leucine-rich repeats and immunoglobulin-like domains protein 2 | chr1 | GO:0045861 | Not Cancer Driver | No | 131 | 0.123 | 231 | 30 | 0.13 | 0 |
| LRP1 | LRP1 | Q07954 | Prolow-density lipoprotein receptor-related protein 1 | chr12 | GO:0045861 | Not Cancer Driver | No | 664 | 0.146 | 317 | 52 | 0.164 | 1 |
| LRRK2 | LRRK2 | Q5S007 | Leucine-rich repeat serine/threonine-protein kinase 2 | chr12 | GO:0045861 | Not Cancer Driver | No | 519 | 0.205 | 90 | 17 | 0.189 | 23 |
| LTF | LTF | P02788 | Lactotransferrin | chr3 | GO:0045861 | Not Cancer Driver | No | 131 | 0.185 | 21 | 4 | 0.19 | 0 |
| MAGEA3 | MAGEA3 | P43357 | Melanoma-associated antigen 3 | chrX | GO:0045861 | Not Cancer Driver | No | 79 | 0.252 | 103 | 18 | 0.175 | 0 |
| MMP9 | MMP9 | P14780 | Matrix metalloproteinase-9 | chr20 | GO:0045861 | Not Cancer Driver | No | 129 | 0.182 | 124 | 26 | 0.21 | 0 |
| MT3 | MT3 | P25713 | Metallothionein-3 | chr16 | GO:0045861 | Not Cancer Driver | No | 7 | 0.103 | 0 | 0 | 0.0 | 0 |
| NLE1 | NLE1 | Q9NVX2 | Notchless protein homolog 1 | chr17 | GO:0045861 | Not Cancer Driver | No | 60 | 0.124 | 21 | 3 | 0.143 | 0 |
| NLRP7_ENST00000590030 | NLRP7 | Q8WX94 | NACHT, LRR and PYD domains-containing protein 7 | chr19 | GO:0045861 | Not Cancer Driver | No | 300 | 0.306 | 71 | 20 | 0.282 | 9 |
| NOL3_ENST00000268605 | NOL3 | O60936 | Nucleolar protein 3 | chr16 | GO:0045861 | Not Cancer Driver | No | 20 | 0.096 | 179 | 17 | 0.095 | 2 |
| NR1H2_ENST00000593926 | NR1H2 | P55055 | Oxysterols receptor LXR-beta | chr19 | GO:0045861 | Not Cancer Driver | No | 56 | 0.122 | 179 | 30 | 0.168 | 0 |
| NR1H3_ENST00000467728 | NR1H3 | Q13133 | Oxysterols receptor LXR-alpha | chr11 | GO:0045861 | Not Cancer Driver | No | 56 | 0.125 | 146 | 13 | 0.089 | 0 |
| PAK2 | PAK2 | Q13177 | Serine/threonine-protein kinase PAK 2 | chr3 | GO:0045861 | Compendium | Yes | 89 | 0.17 | 242 | 49 | 0.202 | 0 |
| PARK7_ENST00000377488 | PARK7 | Q99497 | Parkinson disease protein 7 | chr1 | GO:0045861 | Not Cancer Driver | No | 11 | 0.058 | 30 | 0 | 0.0 | 5 |
| PCID2_ENST00000375479 | PCID2 | Q5JVF3 | PCI domain-containing protein 2 | chr13 | GO:0045861 | Not Cancer Driver | No | 46 | 0.115 | 13 | 5 | 0.385 | 0 |
| PDCL3 | PDCL3 | Q9H2J4 | Phosducin-like protein 3 | chr2 | GO:0045861 | Not Cancer Driver | No | 48 | 0.201 | 73 | 13 | 0.178 | 0 |
| PICALM | PICALM | Q13492 | Phosphatidylinositol-binding clathrin assembly protein | chr11 | GO:0045861 | Census | Yes | 89 | 0.137 | 320 | 42 | 0.131 | 0 |
| PIH1D1 | PIH1D1 | Q9NWS0 | PIH1 domain-containing protein 1 | chr19 | GO:0045861 | Not Cancer Driver | No | 30 | 0.103 | 157 | 13 | 0.083 | 0 |
| PLAT | PLAT | P00750 | Tissue-type plasminogen activator | chr8 | GO:0045861 | Not Cancer Driver | No | 89 | 0.158 | 15 | 2 | 0.133 | 0 |
| PLAUR | PLAUR | Q03405 | Urokinase plasminogen activator surface receptor | chr19 | GO:0045861 | Not Cancer Driver | No | 49 | 0.146 | 18 | 5 | 0.278 | 0 |
| PML | PML | P29590 | Protein PML | chr15 | GO:0045861 | Census, Compendium | Yes | 112 | 0.127 | 312 | 34 | 0.109 | 0 |
| PRNP | PRNP | P04156 | Major prion protein | chr20 | GO:0045861 | Not Cancer Driver | No | 36 | 0.142 | 115 | 7 | 0.061 | 18 |
| PSEN1 | PSEN1 | P49768 | Presenilin-1 | chr14 | GO:0045861 | Not Cancer Driver | No | 61 | 0.131 | 134 | 21 | 0.157 | 96 |
| PTPN3 | PTPN3 | P26045 | Tyrosine-protein phosphatase non-receptor type 3 | chr9 | GO:0045861 | Not Cancer Driver | No | 139 | 0.152 | 214 | 28 | 0.131 | 0 |
| QRICH2 | QRICH2 | Q9H0J4 | Glutamine-rich protein 2 | chr17 | GO:0045861 | Not Cancer Driver | No | 204 | 0.123 | 1369 | 171 | 0.125 | 0 |
| RECK | RECK | O95980 | Reversion-inducing cysteine-rich protein with Kazal motifs | chr9 | GO:0045861 | Not Cancer Driver | No | 115 | 0.118 | 9 | 2 | 0.222 | 0 |
| RFFL_ENST00000394597 | RFFL | Q8WZ73 | E3 ubiquitin-protein ligase rififylin | chr17 | GO:0045861 | Not Cancer Driver | No | 50 | 0.138 | 150 | 21 | 0.14 | 0 |
| RNF34_ENST00000361234 | RNF34 | Q969K3 | E3 ubiquitin-protein ligase RNF34 | chr12 | GO:0045861 | Not Cancer Driver | No | 30 | 0.081 | 112 | 7 | 0.062 | 0 |
| ROCK1 | ROCK1 | Q13464 | Rho-associated protein kinase 1 | chr18 | GO:0045861 | Not Cancer Driver | No | 184 | 0.136 | 780 | 103 | 0.132 | 0 |
| RPL11 | RPL11 | P62913 | 60S ribosomal protein L11 | chr1 | GO:0045861 | Not Cancer Driver | No | 27 | 0.152 | 12 | 1 | 0.083 | 1 |
| RPL23_ENST00000394332 | RPL23 | P62829 | 60S ribosomal protein L23 | chr17 | GO:0045861 | Not Cancer Driver | No | 14 | 0.1 | 29 | 4 | 0.138 | 0 |
| RPL5_ENST00000370321 | RPL5 | P46777 | 60S ribosomal protein L5 | chr1 | GO:0045861 | Census | Yes | 57 | 0.192 | 96 | 17 | 0.177 | 2 |
| RPS7_ENST00000645674 | RPS7 | P62081 | 40S ribosomal protein S7 | chr2 | GO:0045861 | Not Cancer Driver | No | 29 | 0.149 | 39 | 7 | 0.179 | 0 |
| SERPINB3 | SERPINB3 | P29508 | Serpin B3 | chr18 | GO:0045861 | Not Cancer Driver | No | 142 | 0.364 | 47 | 28 | 0.596 | 0 |
| SERPINE1 | SERPINE1 | P05121 | Plasminogen activator inhibitor 1 | chr7 | GO:0045861 | Not Cancer Driver | No | 78 | 0.194 | 7 | 2 | 0.286 | 0 |
| SERPINE2_ENST00000258405 | SERPINE2 | P07093 | Glia-derived nexin | chr2 | GO:0045861 | Not Cancer Driver | No | 62 | 0.156 | 0 | 0 | 0.0 | 0 |
| SERPINF2_ENST00000382061 | SERPINF2 | P08697 | Alpha-2-antiplasmin | chr17 | GO:0045861 | Not Cancer Driver | No | 62 | 0.126 | 112 | 21 | 0.188 | 1 |
| SGTA | SGTA | O43765 | Small glutamine-rich tetratricopeptide repeat-containing protein alpha | chr19 | GO:0045861 | Not Cancer Driver | No | 38 | 0.121 | 159 | 23 | 0.145 | 0 |
| SIRT4 | SIRT4 | Q9Y6E7 | NAD-dependent protein lipoamidase sirtuin-4, mitochondrial | chr12 | GO:0045861 | Not Cancer Driver | No | 46 | 0.146 | 4 | 0 | 0.0 | 0 |
| SNX12 | SNX12 | Q9UMY4 | Sorting nexin-12 | chrX | GO:0045861 | Not Cancer Driver | No | 22 | 0.136 | 28 | 4 | 0.143 | 0 |
| SORL1 | SORL1 | Q92673 | Sortilin-related receptor | chr11 | GO:0045861 | Not Cancer Driver | No | 374 | 0.169 | 87 | 10 | 0.115 | 0 |
| SPINK1 | SPINK1 | P00995 | Serine protease inhibitor Kazal-type 1 | chr5 | GO:0045861 | Not Cancer Driver | No | 14 | 0.177 | 0 | 0 | 0.0 | 3 |
| SPINK2_ENST00000248701 | SPINK2 | P20155 | Serine protease inhibitor Kazal-type 2 | chr4 | GO:0045861 | Not Cancer Driver | No | 10 | 0.119 | 0 | 0 | 0.0 | 0 |
| SPINK5_ENST00000256084 | SPINK5 | Q9NQ38 | Serine protease inhibitor Kazal-type 5 | chr5 | GO:0045861 | Not Cancer Driver | No | 168 | 0.158 | 590 | 102 | 0.173 | 0 |
| SPINK6_ENST00000621437 | SPINK6 | Q6UWN8 | Serine protease inhibitor Kazal-type 6 | chr5 | GO:0045861 | Not Cancer Driver | No | 17 | 0.212 | 0 | 0 | 0.0 | 0 |
| STYX | STYX | Q8WUJ0 | Serine/threonine/tyrosine-interacting protein | chr14 | GO:0045861 | Not Cancer Driver | No | 20 | 0.09 | 30 | 2 | 0.067 | 0 |
| SUFU | SUFU | Q9UMX1 | Suppressor of fused homolog | chr10 | GO:0045861 | Census | Yes | 55 | 0.114 | 199 | 19 | 0.095 | 2 |
| SVIP | SVIP | Q8NHG7 | Small VCP/p97-interacting protein | chr11 | GO:0045861 | Not Cancer Driver | No | 16 | 0.208 | 77 | 16 | 0.208 | 0 |
| TAF1_ENST00000373790 | TAF1 | P21675 | Transcription initiation factor TFIID subunit 1 | chrX | GO:0045861 | Not Cancer Driver | No | 379 | 0.202 | 1152 | 219 | 0.19 | 5 |
| THBS1 | THBS1 | P07996 | Thrombospondin-1 | chr15 | GO:0045861 | Not Cancer Driver | No | 188 | 0.161 | 320 | 58 | 0.181 | 0 |
| TIMP1 | TIMP1 | P01033 | Metalloproteinase inhibitor 1 | chrX | GO:0045861 | Not Cancer Driver | No | 25 | 0.121 | 0 | 0 | 0.0 | 0 |
| TIMP2 | TIMP2 | P16035 | Metalloproteinase inhibitor 2 | chr17 | GO:0045861 | Not Cancer Driver | No | 31 | 0.141 | 6 | 2 | 0.333 | 0 |
| TIMP3 | TIMP3 | P35625 | Metalloproteinase inhibitor 3 | chr22 | GO:0045861 | Not Cancer Driver | No | 43 | 0.204 | 3 | 1 | 0.333 | 5 |
| TIMP4 | TIMP4 | Q99727 | Metalloproteinase inhibitor 4 | chr3 | GO:0045861 | Not Cancer Driver | No | 30 | 0.134 | 8 | 2 | 0.25 | 0 |
| TM4SF20 | TM4SF20 | Q53R12 | Transmembrane 4 L6 family member 20 | chr2 | GO:0045861 | Not Cancer Driver | No | 26 | 0.114 | 4 | 0 | 0.0 | 0 |
| TMED10 | TMED10 | P49755 | Transmembrane emp24 domain-containing protein 10 | chr14 | GO:0045861 | Not Cancer Driver | No | 24 | 0.11 | 15 | 3 | 0.2 | 0 |
| TMEM59 | TMEM59 | Q9BXS4 | Transmembrane protein 59 | chr1 | GO:0045861 | Not Cancer Driver | No | 39 | 0.121 | 26 | 3 | 0.115 | 0 |
| TMEM98 | TMEM98 | Q9Y2Y6 | Transmembrane protein 98 | chr17 | GO:0045861 | Not Cancer Driver | No | 39 | 0.173 | 27 | 3 | 0.111 | 2 |
| TP53_ENST00000445888 | TP53 | P04637 | Cellular tumor antigen p53 | chr17 | GO:0045861 | Census, Compendium | Yes | 2891 | 7.356 | 282 | 1466 | 5.199 | 83 |
| TRIM21 | TRIM21 | P19474 | E3 ubiquitin-protein ligase TRIM21 | chr11 | GO:0045861 | Not Cancer Driver | No | 85 | 0.179 | 49 | 7 | 0.143 | 0 |
| TRIM39 | TRIM39 | Q9HCM9 | E3 ubiquitin-protein ligase TRIM39 | chr6 | GO:0045861 | Not Cancer Driver | No | 74 | 0.143 | 62 | 8 | 0.129 | 0 |
| UBXN1_ENST00000301935 | UBXN1 | Q04323 | UBX domain-containing protein 1 | chr11 | GO:0045861 | Not Cancer Driver | No | 35 | 0.118 | 271 | 33 | 0.122 | 0 |
| USP14 | USP14 | P54578 | Ubiquitin carboxyl-terminal hydrolase 14 | chr18 | GO:0045861 | Not Cancer Driver | No | 59 | 0.119 | 86 | 6 | 0.07 | 0 |
| USP17L2 | USP17L2 | Q6R6M4 | Ubiquitin carboxyl-terminal hydrolase 17 | chr8 | GO:0045861 | Not Cancer Driver | No | 105 | 0.198 | 201 | 54 | 0.269 | 0 |
| USP25_ENST00000285679 | USP25 | Q9UHP3 | Ubiquitin carboxyl-terminal hydrolase 25 | chr21 | GO:0045861 | Not Cancer Driver | No | 135 | 0.128 | 354 | 55 | 0.155 | 0 |
| WNT1 | WNT1 | P04628 | Proto-oncogene Wnt-1 | chr12 | GO:0045861 | Not Cancer Driver | No | 29 | 0.078 | 25 | 0 | 0.0 | 8 |
| XIAP_ENST00000434753 | XIAP | P98170 | E3 ubiquitin-protein ligase XIAP | chrX | GO:0045861 | Not Cancer Driver | No | 89 | 0.179 | 55 | 6 | 0.109 | 0 |