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Total number of protein in "GO:0045860" GO term:  242

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
ABI1 ABI1 Q8IZP0 Abl interactor 1 chr10 GO:0045860 Census, Compendium Yes 55 0.108 360 39 0.108 0
ABL1_ENST00000318560 ABL1 P00519 Tyrosine-protein kinase ABL1 chr9 GO:0045860 Census, Compendium Yes 139 0.123 604 73 0.121 2
ACE ACE P12821 Angiotensin-converting enzyme chr17 GO:0045860 Not Cancer Driver No 201 0.154 86 8 0.093 0
ADAM17 ADAM17 P78536 Disintegrin and metalloproteinase domain-containing protein 17 chr2 GO:0045860 Not Cancer Driver No 80 0.097 182 17 0.093 0
ADCY8 ADCY8 P40145 Adenylate cyclase type 8 chr8 GO:0045860 Not Cancer Driver No 419 0.335 215 38 0.177 0
ADCYAP1_ENST00000450565 ADCYAP1 P18509 Pituitary adenylate cyclase-activating polypeptide chr18 GO:0045860 Not Cancer Driver No 43 0.244 75 11 0.147 0
ADIPOQ ADIPOQ Q15848 Adiponectin chr3 GO:0045860 Not Cancer Driver No 39 0.16 92 21 0.228 1
ADORA1 ADORA1 P30542 Adenosine receptor A1 chr1 GO:0045860 Not Cancer Driver No 64 0.196 12 4 0.333 0
ADRA1A_ENST00000380573 ADRA1A P35348 Alpha-1A adrenergic receptor chr8 GO:0045860 Not Cancer Driver No 130 0.279 40 8 0.2 0
ADRA2A ADRA2A P08913 Alpha-2A adrenergic receptor chr10 GO:0045860 Not Cancer Driver No 67 0.144 161 10 0.062 0
ADRA2B ADRA2B P18089 Alpha-2B adrenergic receptor chr2 GO:0045860 Not Cancer Driver No 73 0.162 136 20 0.147 0
ADRA2C ADRA2C P18825 Alpha-2C adrenergic receptor chr4 GO:0045860 Not Cancer Driver No 47 0.102 107 0 0.0 0
ADRB2 ADRB2 P07550 Beta-2 adrenergic receptor chr5 GO:0045860 Not Cancer Driver No 52 0.126 35 4 0.114 0
AFAP1L2 AFAP1L2 Q8N4X5 Actin filament-associated protein 1-like 2 chr10 GO:0045860 Not Cancer Driver No 86 0.105 558 59 0.106 0
AGAP2 AGAP2 Q99490 Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 chr12 GO:0045860 Not Cancer Driver No 133 0.112 754 81 0.107 0
AGER_ENST00000375076 AGER Q15109 Advanced glycosylation end product-specific receptor chr6 GO:0045860 Not Cancer Driver No 31 0.077 297 21 0.071 0
AGT AGT P01019 Angiotensinogen chr1 GO:0045860 Not Cancer Driver No 85 0.179 33 10 0.303 1
AKT1_ENST00000349310 AKT1 P31749 RAC-alpha serine/threonine-protein kinase chr14 GO:0045860 Census, Compendium Yes 108 0.225 158 24 0.152 4
ALKAL1 ALKAL1 Q6UXT8 ALK and LTK ligand 1 chr8 GO:0045860 Not Cancer Driver No 18 0.14 49 3 0.061 0
ALKAL2 ALKAL2 Q6UX46 ALK and LTK ligand 2 chr2 GO:0045860 Not Cancer Driver No 7 0.046 31 0 0.0 0
ALS2 ALS2 Q96Q42 Alsin chr2 GO:0045860 Not Cancer Driver No 194 0.117 353 36 0.102 0
ANG ANG P03950 Angiogenin chr14 GO:0045860 Not Cancer Driver No 19 0.129 36 2 0.056 14
ANGPT1 ANGPT1 Q15389 Angiopoietin-1 chr8 GO:0045860 Not Cancer Driver No 130 0.261 131 24 0.183 1
ANGPT4 ANGPT4 Q9Y264 Angiopoietin-4 chr20 GO:0045860 Not Cancer Driver No 104 0.207 150 32 0.213 0
AREG AREG P15514 Amphiregulin chr4 GO:0045860 Not Cancer Driver No 28 0.111 149 20 0.134 0
ARHGEF5 ARHGEF5 Q12774 Rho guanine nucleotide exchange factor 5 chr7 GO:0045860 Not Cancer Driver No 170 0.106 1141 127 0.111 0
AXIN1 AXIN1 O15169 Axin-1 chr16 GO:0045860 Census, Compendium Yes 120 0.139 619 88 0.142 4
AXIN2 AXIN2 Q9Y2T1 Axin-2 chr17 GO:0045860 Census, Compendium Yes 114 0.135 547 77 0.141 0
AZU1 AZU1 P20160 Azurocidin chr19 GO:0045860 Not Cancer Driver No 42 0.167 53 13 0.245 0
BTC BTC P35070 Probetacellulin chr4 GO:0045860 Not Cancer Driver No 29 0.163 12 5 0.417 0
CACUL1 CACUL1 Q86Y37 CDK2-associated and cullin domain-containing protein 1 chr10 GO:0045860 Not Cancer Driver No 35 0.095 128 6 0.047 0
CAMKK1_ENST00000348335 CAMKK1 Q8N5S9 Calcium/calmodulin-dependent protein kinase kinase 1 chr17 GO:0045860 Not Cancer Driver No 82 0.162 246 32 0.13 0
CARD10_ENST00000251973 CARD10 Q9BWT7 Caspase recruitment domain-containing protein 10 chr22 GO:0045860 Not Cancer Driver No 94 0.091 474 40 0.084 0
CARD14 CARD14 Q9BXL6 Caspase recruitment domain-containing protein 14 chr17 GO:0045860 Not Cancer Driver No 99 0.099 296 36 0.122 11
CARTPT CARTPT Q16568 Cocaine- and amphetamine-regulated transcript protein chr5 GO:0045860 Not Cancer Driver No 18 0.155 0 0 0.0 0
CASS4 CASS4 Q9NQ75 Cas scaffolding protein family member 4 chr20 GO:0045860 Not Cancer Driver No 204 0.26 496 137 0.276 0
CCDC88A_ENST00000642200 CCDC88A Q3V6T2 Girdin chr2 GO:0045860 Not Cancer Driver No 226 0.121 1481 173 0.117 0
CCL19 CCL19 Q99731 C-C motif chemokine 19 chr9 GO:0045860 Not Cancer Driver No 10 0.102 7 0 0.0 0
CCL21 CCL21 O00585 C-C motif chemokine 21 chr9 GO:0045860 Not Cancer Driver No 14 0.104 59 6 0.102 0
CCN1 CCN1 O00622 CCN family member 1 chr1 GO:0045860 Not Cancer Driver No 33 0.087 12 0 0.0 0
CCNB1 CCNB1 P14635 G2/mitotic-specific cyclin-B1 chr5 GO:0045860 Not Cancer Driver No 49 0.113 145 14 0.097 0
CCND1 CCND1 P24385 G1/S-specific cyclin-D1 chr11 GO:0045860 Census, Compendium Yes 55 0.186 31 25 0.806 0
CCND2 CCND2 P30279 G1/S-specific cyclin-D2 chr12 GO:0045860 Census, Compendium Yes 39 0.135 29 7 0.241 5
CCND3 CCND3 P30281 G1/S-specific cyclin-D3 chr6 GO:0045860 Census, Compendium Yes 29 0.099 46 8 0.174 0
CCNK CCNK O75909 Cyclin-K chr14 GO:0045860 Not Cancer Driver No 39 0.067 347 15 0.043 1
CCNT1 CCNT1 O60563 Cyclin-T1 chr12 GO:0045860 Not Cancer Driver No 85 0.117 495 61 0.123 0
CCNT2 CCNT2 O60583 Cyclin-T2 chr2 GO:0045860 Not Cancer Driver No 76 0.104 471 52 0.11 0
CCNY CCNY Q8ND76 Cyclin-Y chr10 GO:0045860 Not Cancer Driver No 38 0.111 94 6 0.064 0
CCNYL1 CCNYL1 Q8N7R7 Cyclin-Y-like protein 1 chr2 GO:0045860 Not Cancer Driver No 31 0.086 100 8 0.08 0
CCR7 CCR7 P32248 C-C chemokine receptor type 7 chr17 GO:0045860 Census, Compendium Yes 50 0.132 0 0 0.0 0
CD4 CD4 P01730 T-cell surface glycoprotein CD4 chr12 GO:0045860 Not Cancer Driver No 69 0.151 56 11 0.196 0
CD86 CD86 P42081 T-lymphocyte activation antigen CD86 chr3 GO:0045860 Not Cancer Driver No 90 0.274 56 18 0.321 0
CDC25B CDC25B P30305 M-phase inducer phosphatase 2 chr20 GO:0045860 Not Cancer Driver No 80 0.138 328 43 0.131 0
CDC6 CDC6 Q99741 Cell division control protein 6 homolog chr17 GO:0045860 Not Cancer Driver No 57 0.102 170 15 0.088 1
CDK5 CDK5 Q00535 Cyclin-dependent kinase 5 chr7 GO:0045860 Not Cancer Driver No 48 0.164 5 1 0.2 0
CDK5R1 CDK5R1 Q15078 Cyclin-dependent kinase 5 activator 1 chr17 GO:0045860 Not Cancer Driver No 35 0.114 103 16 0.155 0
CDK5R2 CDK5R2 Q13319 Cyclin-dependent kinase 5 activator 2 chr2 GO:0045860 Not Cancer Driver No 14 0.038 204 5 0.025 0
CDKN1A_ENST00000373711 CDKN1A P38936 Cyclin-dependent kinase inhibitor 1 chr6 GO:0045860 Census, Compendium Yes 48 0.293 121 30 0.248 0
CDKN1B CDKN1B P46527 Cyclin-dependent kinase inhibitor 1B chr12 GO:0045860 Census, Compendium Yes 19 0.096 198 19 0.096 0
CEMIP_ENST00000356249 CEMIP Q8WUJ3 Cell migration-inducing and hyaluronan-binding protein chr15 GO:0045860 Not Cancer Driver No 207 0.152 105 10 0.095 0
CENPE CENPE Q02224 Centromere-associated protein E chr4 GO:0045860 Not Cancer Driver No 343 0.127 1620 228 0.141 2
CHI3L1 CHI3L1 P36222 Chitinase-3-like protein 1 chr1 GO:0045860 Not Cancer Driver No 66 0.172 24 5 0.208 0
CHRNA3 CHRNA3 P32297 Neuronal acetylcholine receptor subunit alpha-3 chr15 GO:0045860 Not Cancer Driver No 86 0.17 11 1 0.091 0
CKS1B CKS1B P61024 Cyclin-dependent kinases regulatory subunit 1 chr1 GO:0045860 Not Cancer Driver No 10 0.127 10 0 0.0 0
CKS2 CKS2 P33552 Cyclin-dependent kinases regulatory subunit 2 chr9 GO:0045860 Not Cancer Driver No 9 0.114 10 2 0.2 0
CLU_ENST00000523500 CLU P10909 Clusterin chr8 GO:0045860 Not Cancer Driver No 69 0.154 156 27 0.173 0
COPS8 COPS8 Q99627 COP9 signalosome complex subunit 8 chr2 GO:0045860 Not Cancer Driver No 25 0.12 14 2 0.143 0
CSF1R CSF1R P07333 Macrophage colony-stimulating factor 1 receptor chr5 GO:0045860 Census Yes 133 0.137 124 17 0.137 20
CSF1_ENST00000369802 CSF1 P09603 Macrophage colony-stimulating factor 1 chr1 GO:0045860 Not Cancer Driver No 69 0.125 339 46 0.136 0
DAB1_ENST00000371231 DAB1 O75553 Disabled homolog 1 chr1 GO:0045860 Not Cancer Driver No 200 0.34 393 143 0.364 0
DAB2IP_ENST00000408936 DAB2IP Q5VWQ8 Disabled homolog 2-interacting protein chr9 GO:0045860 Not Cancer Driver No 131 0.11 681 68 0.1 0
DAG1_ENST00000515359 DAG1 Q14118 Dystroglycan 1 chr3 GO:0045860 Not Cancer Driver No 102 0.114 485 61 0.126 4
DAXX_ENST00000266000 DAXX Q9UER7 Death domain-associated protein 6 chr6 GO:0045860 Census, Compendium Yes 106 0.143 549 81 0.148 0
DDR2 DDR2 Q16832 Discoidin domain-containing receptor 2 chr1 GO:0045860 Census Yes 192 0.225 118 34 0.288 7
DGKQ DGKQ P52824 Diacylglycerol kinase theta chr4 GO:0045860 Not Cancer Driver No 56 0.059 264 11 0.042 0
DIPK2A DIPK2A Q8NDZ4 Divergent protein kinase domain 2A chr3 GO:0045860 Not Cancer Driver No 56 0.13 9 0 0.0 0
DKK1 DKK1 O94907 Dickkopf-related protein 1 chr10 GO:0045860 Not Cancer Driver No 58 0.218 47 8 0.17 0
DLG3 DLG3 Q92796 Disks large homolog 3 chrX GO:0045860 Not Cancer Driver No 94 0.115 322 30 0.093 0
DLG4_ENST00000399506 DLG4 P78352 Disks large homolog 4 chr17 GO:0045860 Not Cancer Driver No 116 0.16 232 55 0.237 0
DOCK3 DOCK3 Q8IZD9 Dedicator of cytokinesis protein 3 chr3 GO:0045860 Not Cancer Driver No 365 0.18 458 69 0.151 0
DOK7 DOK7 Q18PE1 Protein Dok-7 chr4 GO:0045860 Not Cancer Driver No 52 0.103 286 27 0.094 19
DUSP19 DUSP19 Q8WTR2 Dual specificity protein phosphatase 19 chr2 GO:0045860 Not Cancer Driver No 34 0.157 15 5 0.333 0
DVL2 DVL2 O14641 Segment polarity protein dishevelled homolog DVL-2 chr17 GO:0045860 Not Cancer Driver No 96 0.13 514 64 0.125 0
DVL3 DVL3 Q92997 Segment polarity protein dishevelled homolog DVL-3 chr3 GO:0045860 Not Cancer Driver No 97 0.135 437 58 0.133 0
DYNAP DYNAP Q8N1N2 Dynactin-associated protein chr18 GO:0045860 Not Cancer Driver No 54 0.257 78 21 0.269 0
EDN1 EDN1 P05305 Endothelin-1 chr6 GO:0045860 Not Cancer Driver No 37 0.175 97 20 0.206 3
EFNA1 EFNA1 P20827 Ephrin-A1 chr1 GO:0045860 Not Cancer Driver No 29 0.141 46 5 0.109 0
EFNA5 EFNA5 P52803 Ephrin-A5 chr5 GO:0045860 Not Cancer Driver No 34 0.149 25 6 0.24 0
EGF EGF P01133 Pro-epidermal growth factor chr4 GO:0045860 Not Cancer Driver No 184 0.152 191 25 0.131 1
EGFR EGFR P00533 Epidermal growth factor receptor chr7 GO:0045860 Census, Compendium Yes 444 0.367 223 35 0.157 1
EGR1 EGR1 P18146 Early growth response protein 1 chr5 GO:0045860 Not Cancer Driver No 78 0.144 501 72 0.144 0
EPGN EPGN Q6UW88 Epigen chr4 GO:0045860 Not Cancer Driver No 16 0.104 0 0 0.0 0
EPHA4_ENST00000409938 EPHA4 P54764 Ephrin type-A receptor 4 chr2 GO:0045860 Not Cancer Driver No 182 0.185 140 24 0.171 0
ERBB3 ERBB3 P21860 Receptor tyrosine-protein kinase erbB-3 chr12 GO:0045860 Census, Compendium Yes 298 0.222 396 70 0.177 3
ERCC6 ERCC6 Q03468 DNA excision repair protein ERCC-6 chr10 GO:0045860 Not Cancer Driver No 211 0.141 829 117 0.141 9
EREG EREG O14944 Proepiregulin chr4 GO:0045860 Not Cancer Driver No 26 0.154 10 3 0.3 0
ERN1 ERN1 O75460 Serine/threonine-protein kinase/endoribonuclease IRE1 chr17 GO:0045860 Not Cancer Driver No 125 0.128 250 28 0.112 0
ERN2 ERN2 Q76MJ5 Serine/threonine-protein kinase/endoribonuclease IRE2 chr16 GO:0045860 Not Cancer Driver No 192 0.207 213 45 0.211 0
FBXW7_ENST00000603841 FBXW7 Q969H0 F-box/WD repeat-containing protein 7 chr4 GO:0045860 Census, Compendium Yes 322 0.455 230 38 0.165 0
FCGR1A FCGR1A P12314 High affinity immunoglobulin gamma Fc receptor I chr1 GO:0045860 Not Cancer Driver No 62 0.166 37 5 0.135 0
FERMT2_ENST00000395631 FERMT2 Q96AC1 Fermitin family homolog 2 chr14 GO:0045860 Not Cancer Driver No 71 0.104 101 10 0.099 0
FGD2 FGD2 Q7Z6J4 FYVE, RhoGEF and PH domain-containing protein 2 chr6 GO:0045860 Not Cancer Driver No 113 0.173 158 26 0.165 0
FGF1_ENST00000612258 FGF1 P05230 Fibroblast growth factor 1 chr5 GO:0045860 Not Cancer Driver No 30 0.194 29 2 0.069 0
FZD10 FZD10 Q9ULW2 Frizzled-10 chr12 GO:0045860 Not Cancer Driver No 148 0.255 65 15 0.231 0
FZD4 FZD4 Q9ULV1 Frizzled-4 chr11 GO:0045860 Not Cancer Driver No 57 0.106 33 5 0.152 19
FZD5 FZD5 Q13467 Frizzled-5 chr2 GO:0045860 Not Cancer Driver No 45 0.077 58 4 0.069 0
FZD8 FZD8 Q9H461 Frizzled-8 chr10 GO:0045860 Not Cancer Driver No 72 0.104 146 3 0.021 0
GAS6 GAS6 Q14393 Growth arrest-specific protein 6 chr13 GO:0045860 Not Cancer Driver No 82 0.121 42 6 0.143 0
GCG GCG P01275 Pro-glucagon chr2 GO:0045860 Not Cancer Driver No 49 0.272 82 22 0.268 0
GH1 GH1 P01241 Somatotropin chr17 GO:0045860 Not Cancer Driver No 54 0.249 24 9 0.375 15
GHRL_ENST00000457360 GHRL Q9UBU3 Appetite-regulating hormone chr3 GO:0045860 Not Cancer Driver No 20 0.171 52 11 0.212 0
GHR_ENST00000612382 GHR P10912 Growth hormone receptor chr5 GO:0045860 Not Cancer Driver No 173 0.271 229 66 0.288 19
GPRC5B_ENST00000569479 GPRC5B Q9NZH0 G-protein coupled receptor family C group 5 member B chr16 GO:0045860 Not Cancer Driver No 82 0.203 75 19 0.253 0
GREM1 GREM1 O60565 Gremlin-1 chr15 GO:0045860 Not Cancer Driver No 25 0.136 77 12 0.156 0
GRM5 GRM5 P41594 Metabotropic glutamate receptor 5 chr11 GO:0045860 Not Cancer Driver No 312 0.257 323 51 0.158 0
HBEGF HBEGF Q99075 Proheparin-binding EGF-like growth factor chr5 GO:0045860 Not Cancer Driver No 16 0.077 63 3 0.048 0
HSP90AA1_ENST00000216281 HSP90AA1 P07900 Heat shock protein HSP 90-alpha chr14 GO:0045860 Census, Compendium Yes 106 0.145 257 37 0.144 0
HSP90AB1 HSP90AB1 P08238 Heat shock protein HSP 90-beta chr6 GO:0045860 Census, Compendium Yes 100 0.138 254 43 0.169 0
IGF1_ENST00000307046 IGF1 P05019 Insulin-like growth factor I chr12 GO:0045860 Not Cancer Driver No 45 0.231 87 23 0.264 0
IL12B IL12B P29460 Interleukin-12 subunit beta chr5 GO:0045860 Not Cancer Driver No 48 0.146 42 2 0.048 0
IL18 IL18 Q14116 Interleukin-18 chr11 GO:0045860 Not Cancer Driver No 19 0.098 16 3 0.188 0
IL1B IL1B P01584 Interleukin-1 beta chr2 GO:0045860 Not Cancer Driver No 39 0.145 16 3 0.188 0
IL23A IL23A Q9NPF7 Interleukin-23 subunit alpha chr12 GO:0045860 Not Cancer Driver No 15 0.079 42 3 0.071 0
IL23R IL23R Q5VWK5 Interleukin-23 receptor chr1 GO:0045860 Not Cancer Driver No 70 0.111 117 19 0.162 0
IL34 IL34 Q6ZMJ4 Interleukin-34 chr16 GO:0045860 Not Cancer Driver No 22 0.091 42 6 0.143 0
IL4 IL4 P05112 Interleukin-4 chr5 GO:0045860 Not Cancer Driver No 18 0.118 0 0 0.0 0
IL6R IL6R P08887 Interleukin-6 receptor subunit alpha chr1 GO:0045860 Not Cancer Driver No 55 0.118 165 23 0.139 1
INS INS P01308 Insulin chr11 GO:0045860 Not Cancer Driver No 15 0.136 5 1 0.2 22
INSR INSR P06213 Insulin receptor chr19 GO:0045860 Not Cancer Driver No 190 0.137 280 57 0.204 64
IQGAP1 IQGAP1 P46940 Ras GTPase-activating-like protein IQGAP1 chr15 GO:0045860 Not Cancer Driver No 183 0.11 351 35 0.1 0
IRAK1 IRAK1 P51617 Interleukin-1 receptor-associated kinase 1 chrX GO:0045860 Compendium Yes 71 0.1 337 39 0.116 0
ITGB1BP1_ENST00000355346 ITGB1BP1 O14713 Integrin beta-1-binding protein 1 chr2 GO:0045860 Not Cancer Driver No 26 0.13 58 11 0.19 0
JAK2 JAK2 O60674 Tyrosine-protein kinase JAK2 chr9 GO:0045860 Census, Compendium Yes 136 0.12 59 5 0.085 5
JTB JTB O76095 Protein JTB chr1 GO:0045860 Not Cancer Driver No 14 0.096 4 1 0.25 0
LAT_ENST00000360872 LAT O43561 Linker for activation of T-cells family member 1 chr16 GO:0045860 Not Cancer Driver No 37 0.141 213 29 0.136 0
LCP2 LCP2 Q13094 Lymphocyte cytosolic protein 2 chr5 GO:0045860 Not Cancer Driver No 107 0.201 390 80 0.205 0
LEP LEP P41159 Leptin chr7 GO:0045860 Not Cancer Driver No 29 0.174 0 0 0.0 2
LILRA5 LILRA5 A6NI73 Leukocyte immunoglobulin-like receptor subfamily A member 5 chr19 GO:0045860 Not Cancer Driver No 79 0.264 98 19 0.194 0
LRP8 LRP8 Q14114 Low-density lipoprotein receptor-related protein 8 chr1 GO:0045860 Not Cancer Driver No 94 0.098 190 24 0.126 0
LRRK2 LRRK2 Q5S007 Leucine-rich repeat serine/threonine-protein kinase 2 chr12 GO:0045860 Not Cancer Driver No 519 0.205 90 17 0.189 23
MALT1 MALT1 Q9UDY8 Mucosa-associated lymphoid tissue lymphoma translocation protein 1 chr18 GO:0045860 Census, Compendium Yes 75 0.091 139 12 0.086 1
MAP2K3 MAP2K3 P46734 Dual specificity mitogen-activated protein kinase kinase 3 chr17 GO:0045860 Not Cancer Driver No 104 0.3 75 27 0.36 0
MAP2K7_ENST00000397979 MAP2K7 O14733 Dual specificity mitogen-activated protein kinase kinase 7 chr19 GO:0045860 Compendium Yes 89 0.212 144 20 0.139 0
MAP3K10 MAP3K10 Q02779 Mitogen-activated protein kinase kinase kinase 10 chr19 GO:0045860 Not Cancer Driver No 112 0.117 589 62 0.105 0
MAP3K11 MAP3K11 Q16584 Mitogen-activated protein kinase kinase kinase 11 chr11 GO:0045860 Not Cancer Driver No 97 0.115 466 54 0.116 0
MAP3K12_ENST00000267079 MAP3K12 Q12852 Mitogen-activated protein kinase kinase kinase 12 chr12 GO:0045860 Not Cancer Driver No 120 0.14 481 64 0.133 0
MAP3K13_ENST00000424227 MAP3K13 O43283 Mitogen-activated protein kinase kinase kinase 13 chr3 GO:0045860 Census Yes 157 0.163 593 91 0.153 0
MAP3K4 MAP3K4 Q9Y6R4 Mitogen-activated protein kinase kinase kinase 4 chr6 GO:0045860 Not Cancer Driver No 261 0.162 520 86 0.165 0
MAP3K5 MAP3K5 Q99683 Mitogen-activated protein kinase kinase kinase 5 chr6 GO:0045860 Not Cancer Driver No 197 0.143 242 29 0.12 0
MAP3K7 MAP3K7 O43318 Mitogen-activated protein kinase kinase kinase 7 chr6 GO:0045860 Not Cancer Driver No 104 0.172 333 66 0.198 6
MAP4K2 MAP4K2 Q12851 Mitogen-activated protein kinase kinase kinase kinase 2 chr11 GO:0045860 Not Cancer Driver No 78 0.095 243 23 0.095 0
MAPRE3 MAPRE3 Q9UPY8 Microtubule-associated protein RP/EB family member 3 chr2 GO:0045860 Not Cancer Driver No 37 0.132 120 16 0.133 0
MAS1 MAS1 P04201 Proto-oncogene Mas chr6 GO:0045860 Not Cancer Driver No 47 0.145 5 2 0.4 0
MMD MMD Q15546 Monocyte to macrophage differentiation factor chr17 GO:0045860 Not Cancer Driver No 30 0.126 0 0 0.0 0
MMD2 MMD2 Q8IY49 Monocyte to macrophage differentiation factor 2 chr7 GO:0045860 Not Cancer Driver No 58 0.215 0 0 0.0 0
MNAT1 MNAT1 P51948 CDK-activating kinase assembly factor MAT1 chr14 GO:0045860 Not Cancer Driver No 23 0.074 64 2 0.031 0
MRNIP MRNIP Q6NTE8 MRN complex-interacting protein chr5 GO:0045860 Not Cancer Driver No 44 0.128 268 35 0.131 0
MT3 MT3 P25713 Metallothionein-3 chr16 GO:0045860 Not Cancer Driver No 7 0.103 0 0 0.0 0
MTOR MTOR P42345 Serine/threonine-protein kinase mTOR chr1 GO:0045860 Census, Compendium Yes 379 0.149 296 37 0.125 18
NAB2 NAB2 Q15742 NGFI-A-binding protein 2 chr12 GO:0045860 Census Yes 67 0.128 395 51 0.129 0
NCF1 NCF1 P14598 Neutrophil cytosol factor 1 chr7 GO:0045860 Not Cancer Driver No 37 0.095 181 12 0.066 1
NEDD9 NEDD9 Q14511 Enhancer of filamentation 1 chr6 GO:0045860 Not Cancer Driver No 106 0.127 516 72 0.14 0
NEURL1 NEURL1 O76050 E3 ubiquitin-protein ligase NEURL1 chr10 GO:0045860 Not Cancer Driver No 62 0.108 153 11 0.072 0
NOX4 NOX4 Q9NPH5 NADPH oxidase 4 chr11 GO:0045860 Not Cancer Driver No 123 0.213 0 0 0.0 0
NRG1_ENST00000405005 NRG1 Q02297 Pro-neuregulin-1, membrane-bound isoform chr8 GO:0045860 Census, Compendium Yes 159 0.248 528 132 0.25 0
NRG3_ENST00000404547 NRG3 P56975 Pro-neuregulin-3, membrane-bound isoform chr10 GO:0045860 Not Cancer Driver No 227 0.315 425 134 0.315 0
NTF3_ENST00000331010 NTF3 P20783 Neurotrophin-3 chr12 GO:0045860 Not Cancer Driver No 52 0.202 99 21 0.212 0
NTRK3_ENST00000629765 NTRK3 Q16288 NT-3 growth factor receptor chr15 GO:0045860 Census, Compendium Yes 249 0.297 57 21 0.368 0
OSBPL8 OSBPL8 Q9BZF1 Oxysterol-binding protein-related protein 8 chr12 GO:0045860 Not Cancer Driver No 105 0.118 401 37 0.092 0
PAK1_ENST00000356341 PAK1 Q13153 Serine/threonine-protein kinase PAK 1 chr11 GO:0045860 Not Cancer Driver No 57 0.105 299 30 0.1 2
PAK2 PAK2 Q13177 Serine/threonine-protein kinase PAK 2 chr3 GO:0045860 Compendium Yes 89 0.17 242 49 0.202 0
PARK7_ENST00000377488 PARK7 Q99497 Parkinson disease protein 7 chr1 GO:0045860 Not Cancer Driver No 11 0.058 30 0 0.0 5
PDGFB PDGFB P01127 Platelet-derived growth factor subunit B chr22 GO:0045860 Census Yes 37 0.154 99 22 0.222 2
PDGFC PDGFC Q9NRA1 Platelet-derived growth factor C chr4 GO:0045860 Not Cancer Driver No 86 0.249 53 12 0.226 0
PDPK1 PDPK1 O15530 3-phosphoinositide-dependent protein kinase 1 chr16 GO:0045860 Not Cancer Driver No 33 0.059 121 12 0.099 0
PHB2 PHB2 Q99623 Prohibitin-2 chr12 GO:0045860 Not Cancer Driver No 31 0.104 26 4 0.154 0
PHB_ENST00000300408 PHB1 P35232 Prohibitin 1 chr17 GO:0045860 Not Cancer Driver No 37 0.136 4 1 0.25 0
PIBF1 PIBF1 Q8WXW3 Progesterone-induced-blocking factor 1 chr13 GO:0045860 Not Cancer Driver No 83 0.11 419 45 0.107 2
PILRB PILRB Q9UKJ0 Paired immunoglobulin-like type 2 receptor beta chr7 GO:0045860 Not Cancer Driver No 29 0.128 26 3 0.115 0
PINK1 PINK1 Q9BXM7 Serine/threonine-protein kinase PINK1, mitochondrial chr1 GO:0045860 Not Cancer Driver No 57 0.098 99 13 0.131 23
PKD1 PKD1 P98161 Polycystin-1 chr16 GO:0045860 Not Cancer Driver No 393 0.091 690 66 0.096 92
PKD2 PKD2 Q13563 Polycystin-2 chr4 GO:0045860 Not Cancer Driver No 113 0.117 375 35 0.093 10
PPIA PPIA P62937 Peptidyl-prolyl cis-trans isomerase A chr7 GO:0045860 Not Cancer Driver No 11 0.067 24 3 0.125 0
PRKAG1_ENST00000548065 PRKAG1 P54619 5'-AMP-activated protein kinase subunit gamma-1 chr12 GO:0045860 Not Cancer Driver No 35 0.106 25 2 0.08 0
PRKAG2 PRKAG2 Q9UGJ0 5'-AMP-activated protein kinase subunit gamma-2 chr7 GO:0045860 Not Cancer Driver No 76 0.134 240 45 0.188 7
PRKCZ PRKCZ Q05513 Protein kinase C zeta type chr1 GO:0045860 Not Cancer Driver No 70 0.118 116 11 0.095 0
PRLR PRLR P16471 Prolactin receptor chr5 GO:0045860 Not Cancer Driver No 154 0.248 282 70 0.248 2
PRNP PRNP P04156 Major prion protein chr20 GO:0045860 Not Cancer Driver No 36 0.142 115 7 0.061 18
PROX1 PROX1 Q92786 Prospero homeobox protein 1 chr1 GO:0045860 Not Cancer Driver No 182 0.247 537 141 0.263 0
PRRC1_ENST00000296666 PRRC1 Q96M27 Protein PRRC1 chr5 GO:0045860 Not Cancer Driver No 42 0.094 235 24 0.102 0
PSMD10 PSMD10 O75832 26S proteasome non-ATPase regulatory subunit 10 chrX GO:0045860 Not Cancer Driver No 20 0.088 53 5 0.094 0
PSRC1_ENST00000409138 PSRC1 Q6PGN9 Proline/serine-rich coiled-coil protein 1 chr1 GO:0045860 Not Cancer Driver No 30 0.083 361 30 0.083 0
PTK2B_ENST00000346049 PTK2B Q14289 Protein-tyrosine kinase 2-beta chr8 GO:0045860 Not Cancer Driver No 161 0.16 261 37 0.142 0
PTK2_ENST00000522684 PTK2 Q05397 Focal adhesion kinase 1 chr8 GO:0045860 Not Cancer Driver No 134 0.127 425 55 0.129 0
PTPN1 PTPN1 P18031 Tyrosine-protein phosphatase non-receptor type 1 chr20 GO:0045860 Not Cancer Driver No 49 0.113 140 25 0.179 0
PTPRC PTPRC P08575 Receptor-type tyrosine-protein phosphatase C chr1 GO:0045860 Census, Compendium Yes 315 0.241 462 107 0.232 0
RAP1A_ENST00000356415 RAP1A P62834 Ras-related protein Rap-1A chr1 GO:0045860 Not Cancer Driver No 27 0.147 5 0 0.0 0
RAPGEF2 RAPGEF2 Q9Y4G8 Rap guanine nucleotide exchange factor 2 chr4 GO:0045860 Not Cancer Driver No 216 0.144 803 116 0.144 0
RASSF2 RASSF2 P50749 Ras association domain-containing protein 2 chr20 GO:0045860 Not Cancer Driver No 90 0.276 126 44 0.349 0
RELN RELN P78509 Reelin chr7 GO:0045860 Not Cancer Driver No 761 0.22 107 19 0.178 7
RGCC RGCC Q9H4X1 Regulator of cell cycle RGCC chr13 GO:0045860 Not Cancer Driver No 9 0.066 81 7 0.086 0
ROR2 ROR2 Q01974 Tyrosine-protein kinase transmembrane receptor ROR2 chr9 GO:0045860 Not Cancer Driver No 203 0.215 299 71 0.237 5
RPS3_ENST00000527446 RPS3 P23396 40S ribosomal protein S3 chr11 GO:0045860 Not Cancer Driver No 22 0.091 48 4 0.083 0
SASH1 SASH1 O94885 SAM and SH3 domain-containing protein 1 chr6 GO:0045860 Not Cancer Driver No 174 0.14 1071 153 0.143 7
SDC4 SDC4 P31431 Syndecan-4 chr20 GO:0045860 Census, Compendium Yes 34 0.172 110 25 0.227 0
SIRT1 SIRT1 Q96EB6 NAD-dependent protein deacetylase sirtuin-1 chr10 GO:0045860 Not Cancer Driver No 70 0.094 435 31 0.071 0
SLC1A1 SLC1A1 P43005 Excitatory amino acid transporter 3 chr9 GO:0045860 Not Cancer Driver No 69 0.132 17 4 0.235 1
SNX9 SNX9 Q9Y5X1 Sorting nexin-9 chr6 GO:0045860 Not Cancer Driver No 71 0.119 231 23 0.1 0
SPATC1L SPATC1L Q9H0A9 Speriolin-like protein chr21 GO:0045860 Not Cancer Driver No 30 0.088 179 11 0.061 0
SPDYA_ENST00000379579 SPDYA Q5MJ70 Speedy protein A chr2 GO:0045860 Not Cancer Driver No 39 0.125 119 11 0.092 0
SRC_ENST00000358208 SRC P12931 Proto-oncogene tyrosine-protein kinase Src chr20 GO:0045860 Census Yes 53 0.099 130 11 0.085 1
STAP1_ENST00000396225 STAP1 Q9ULZ2 Signal-transducing adaptor protein 1 chr4 GO:0045860 Not Cancer Driver No 66 0.224 103 18 0.175 0
STOX1_ENST00000399169 STOX1 Q6ZVD7 Storkhead-box protein 1 chr10 GO:0045860 Not Cancer Driver No 121 0.122 659 83 0.126 2
SYK_ENST00000375746 SYK P43405 Tyrosine-protein kinase SYK chr9 GO:0045860 Census Yes 96 0.151 131 27 0.206 5
TAB2_ENST00000637181 TAB2 Q9NYJ8 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 chr6 GO:0045860 Not Cancer Driver No 87 0.126 573 73 0.127 2
TAL1 TAL1 P17542 T-cell acute lymphocytic leukemia protein 1 chr1 GO:0045860 Census Yes 54 0.163 305 53 0.174 0
TAOK3 TAOK3 Q9H2K8 Serine/threonine-protein kinase TAO3 chr12 GO:0045860 Not Cancer Driver No 123 0.137 494 64 0.13 0
TCIM TCIM Q9NR00 Transcriptional and immune response regulator chr8 GO:0045860 Not Cancer Driver No 21 0.198 33 7 0.212 0
TGFA_ENST00000295400 TGFA P01135 Protransforming growth factor alpha chr2 GO:0045860 Not Cancer Driver No 20 0.125 0 0 0.0 0
TIRAP_ENST00000392680 TIRAP P58753 Toll/interleukin-1 receptor domain-containing adapter protein chr11 GO:0045860 Not Cancer Driver No 28 0.127 80 6 0.075 0
TLR3 TLR3 O15455 Toll-like receptor 3 chr4 GO:0045860 Not Cancer Driver No 123 0.136 0 0 0.0 1
TLR6 TLR6 Q9Y2C9 Toll-like receptor 6 chr4 GO:0045860 Not Cancer Driver No 99 0.124 1 0 0.0 0
TLR9 TLR9 Q9NR96 Toll-like receptor 9 chr3 GO:0045860 Not Cancer Driver No 141 0.137 35 3 0.086 0
TNF TNF P01375 Tumor necrosis factor chr6 GO:0045860 Not Cancer Driver No 24 0.103 45 3 0.067 0
TNFRSF10A TNFRSF10A O00220 Tumor necrosis factor receptor superfamily member 10A chr8 GO:0045860 Not Cancer Driver No 55 0.118 174 17 0.098 0
TNFRSF10B TNFRSF10B O14763 Tumor necrosis factor receptor superfamily member 10B chr8 GO:0045860 Not Cancer Driver No 44 0.1 190 19 0.1 0
TNFRSF11A TNFRSF11A Q9Y6Q6 Tumor necrosis factor receptor superfamily member 11A chr18 GO:0045860 Not Cancer Driver No 70 0.114 285 33 0.116 0
TNFSF15 TNFSF15 O95150 Tumor necrosis factor ligand superfamily member 15 chr9 GO:0045860 Not Cancer Driver No 41 0.163 49 12 0.245 0
TRAF2 TRAF2 Q12933 TNF receptor-associated factor 2 chr9 GO:0045860 Not Cancer Driver No 63 0.126 4 1 0.25 0
TRAF4 TRAF4 Q9BUZ4 TNF receptor-associated factor 4 chr17 GO:0045860 Not Cancer Driver No 42 0.089 27 1 0.037 0
TRAF6_ENST00000348124 TRAF6 Q9Y4K3 TNF receptor-associated factor 6 chr11 GO:0045860 Not Cancer Driver No 67 0.128 62 7 0.113 0
TTBK1 TTBK1 Q5TCY1 Tau-tubulin kinase 1 chr6 GO:0045860 Not Cancer Driver No 193 0.146 1045 154 0.147 0
TXN TXN P10599 Thioredoxin chr9 GO:0045860 Not Cancer Driver No 6 0.057 0 0 0.0 0
UCN UCN P55089 Urocortin chr2 GO:0045860 Not Cancer Driver No 7 0.056 61 4 0.066 0
UNC119 UNC119 Q13432 Protein unc-119 homolog A chr17 GO:0045860 Not Cancer Driver No 20 0.083 89 4 0.045 1
VEGFC VEGFC P49767 Vascular endothelial growth factor C chr4 GO:0045860 Not Cancer Driver No 128 0.305 37 12 0.324 0
VLDLR VLDLR P98155 Very low-density lipoprotein receptor chr9 GO:0045860 Not Cancer Driver No 90 0.103 55 3 0.055 0
WNT3A WNT3A P56704 Protein Wnt-3a chr1 GO:0045860 Not Cancer Driver No 77 0.219 37 5 0.135 0
WNT5A_ENST00000474267 WNT5A P41221 Protein Wnt-5a chr3 GO:0045860 Not Cancer Driver No 66 0.174 0 0 0.0 2
XRCC5_ENST00000392132 XRCC5 P13010 X-ray repair cross-complementing protein 5 chr2 GO:0045860 Not Cancer Driver No 87 0.119 118 11 0.093 0
XRCC6 XRCC6 P12956 X-ray repair cross-complementing protein 6 chr22 GO:0045860 Not Cancer Driver No 66 0.108 140 12 0.086 0
ZFP91 ZFP91 Q96JP5 E3 ubiquitin-protein ligase ZFP91 chr11 GO:0045860 Not Cancer Driver No 85 0.149 383 55 0.144 0