Total number of protein in "GO:0045665" GO term: 72
| Identifier | UniProt Gene | UniProt Accession | UniProt Name | Chromosome | GO term | Database | Cancer Driver | Number of missense mutations | Missense mutation per residues | Number of disordered residues | Number of mutations in disordered regions | Disordered missense mutations per residues | Number of OMIM mutation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| APP | APP | P05067 | Amyloid-beta precursor protein | chr21 | GO:0045665 | Not Cancer Driver | No | 128 | 0.166 | 418 | 71 | 0.17 | 17 |
| ASCL1 | ASCL1 | P50553 | Achaete-scute homolog 1 | chr12 | GO:0045665 | Not Cancer Driver | No | 33 | 0.14 | 182 | 24 | 0.132 | 0 |
| ASPM | ASPM | Q8IZT6 | Abnormal spindle-like microcephaly-associated protein | chr1 | GO:0045665 | Not Cancer Driver | No | 554 | 0.159 | 424 | 67 | 0.158 | 0 |
| B2M | B2M | P61769 | Beta-2-microglobulin | chr15 | GO:0045665 | Census, Compendium | Yes | 34 | 0.286 | 5 | 1 | 0.2 | 2 |
| BMP7 | BMP7 | P18075 | Bone morphogenetic protein 7 | chr20 | GO:0045665 | Not Cancer Driver | No | 91 | 0.211 | 69 | 18 | 0.261 | 0 |
| CALR | CALR | P27797 | Calreticulin | chr19 | GO:0045665 | Census | Yes | 45 | 0.108 | 245 | 31 | 0.127 | 0 |
| CDK5RAP2 | CDK5RAP2 | Q96SN8 | CDK5 regulatory subunit-associated protein 2 | chr9 | GO:0045665 | Not Cancer Driver | No | 217 | 0.115 | 1136 | 128 | 0.113 | 0 |
| CNTF | CNTF | P26441 | Ciliary neurotrophic factor | chr11 | GO:0045665 | Not Cancer Driver | No | 41 | 0.205 | 34 | 5 | 0.147 | 0 |
| CNTN2 | CNTN2 | Q02246 | Contactin-2 | chr1 | GO:0045665 | Not Cancer Driver | No | 155 | 0.149 | 370 | 61 | 0.165 | 0 |
| CNTN4_ENST00000418658 | CNTN4 | Q8IWV2 | Contactin-4 | chr3 | GO:0045665 | Not Cancer Driver | No | 300 | 0.292 | 301 | 84 | 0.279 | 0 |
| CTDSP1 | CTDSP1 | Q9GZU7 | Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 | chr2 | GO:0045665 | Not Cancer Driver | No | 34 | 0.13 | 46 | 2 | 0.043 | 0 |
| DDX6 | DDX6 | P26196 | Probable ATP-dependent RNA helicase DDX6 | chr11 | GO:0045665 | Census, Compendium | Yes | 44 | 0.091 | 129 | 7 | 0.054 | 5 |
| DISP3 | DISP3 | Q9P2K9 | Protein dispatched homolog 3 | chr1 | GO:0045665 | Not Cancer Driver | No | 320 | 0.23 | 172 | 44 | 0.256 | 0 |
| DIXDC1 | DIXDC1 | Q155Q3 | Dixin | chr11 | GO:0045665 | Not Cancer Driver | No | 72 | 0.105 | 495 | 55 | 0.111 | 0 |
| DLL1 | DLL1 | O00548 | Delta-like protein 1 | chr6 | GO:0045665 | Not Cancer Driver | No | 115 | 0.159 | 145 | 24 | 0.166 | 1 |
| DLX1 | DLX1 | P56177 | Homeobox protein DLX-1 | chr2 | GO:0045665 | Not Cancer Driver | No | 25 | 0.098 | 183 | 21 | 0.115 | 0 |
| DLX2 | DLX2 | Q07687 | Homeobox protein DLX-2 | chr2 | GO:0045665 | Not Cancer Driver | No | 46 | 0.14 | 262 | 38 | 0.145 | 0 |
| DTX1 | DTX1 | Q86Y01 | E3 ubiquitin-protein ligase DTX1 | chr12 | GO:0045665 | Compendium | Yes | 107 | 0.173 | 304 | 43 | 0.141 | 0 |
| EIF2AK4 | EIF2AK4 | Q9P2K8 | eIF-2-alpha kinase GCN2 | chr15 | GO:0045665 | Not Cancer Driver | No | 156 | 0.095 | 494 | 44 | 0.089 | 2 |
| EIF4ENIF1 | EIF4ENIF1 | Q9NRA8 | Eukaryotic translation initiation factor 4E transporter | chr22 | GO:0045665 | Not Cancer Driver | No | 116 | 0.118 | 899 | 101 | 0.112 | 0 |
| EIF4E_ENST00000450253 | EIF4E | P06730 | Eukaryotic translation initiation factor 4E | chr4 | GO:0045665 | Not Cancer Driver | No | 26 | 0.12 | 54 | 6 | 0.111 | 0 |
| FEZF2_ENST00000475839 | FEZF2 | Q8TBJ5 | Fez family zinc finger protein 2 | chr3 | GO:0045665 | Not Cancer Driver | No | 65 | 0.142 | 144 | 14 | 0.097 | 0 |
| FOXG1 | FOXG1 | P55316 | Forkhead box protein G1 | chr14 | GO:0045665 | Not Cancer Driver | No | 132 | 0.27 | 322 | 79 | 0.245 | 2 |
| FOXO3 | FOXO3 | O43524 | Forkhead box protein O3 | chr6 | GO:0045665 | Census, Compendium | Yes | 70 | 0.104 | 595 | 68 | 0.114 | 0 |
| GDF11 | GDF11 | O95390 | Growth/differentiation factor 11 | chr12 | GO:0045665 | Not Cancer Driver | No | 40 | 0.098 | 109 | 7 | 0.064 | 1 |
| GLI3 | GLI3 | P10071 | Transcriptional activator GLI3 | chr7 | GO:0045665 | Not Cancer Driver | No | 385 | 0.244 | 1352 | 327 | 0.242 | 7 |
| GPR37L1 | GPR37L1 | O60883 | G-protein coupled receptor 37-like 1 | chr1 | GO:0045665 | Not Cancer Driver | No | 62 | 0.129 | 81 | 8 | 0.099 | 0 |
| GSK3B_ENST00000264235 | GSK3B | P49841 | Glycogen synthase kinase-3 beta | chr3 | GO:0045665 | Not Cancer Driver | No | 56 | 0.133 | 146 | 13 | 0.089 | 0 |
| HES1 | HES1 | Q14469 | Transcription factor HES-1 | chr3 | GO:0045665 | Not Cancer Driver | No | 37 | 0.132 | 226 | 32 | 0.142 | 0 |
| HES3 | HES3 | Q5TGS1 | Transcription factor HES-3 | chr1 | GO:0045665 | Not Cancer Driver | No | 13 | 0.07 | 129 | 10 | 0.078 | 0 |
| HES5 | HES5 | Q5TA89 | Transcription factor HES-5 | chr1 | GO:0045665 | Not Cancer Driver | No | 1 | 0.006 | 73 | 0 | 0.0 | 0 |
| HEY1_ENST00000354724 | HEY1 | Q9Y5J3 | Hairy/enhancer-of-split related with YRPW motif protein 1 | chr8 | GO:0045665 | Census | Yes | 33 | 0.109 | 172 | 15 | 0.087 | 0 |
| HMG20A | HMG20A | Q9NP66 | High mobility group protein 20A | chr15 | GO:0045665 | Not Cancer Driver | No | 58 | 0.167 | 308 | 44 | 0.143 | 0 |
| HOXA2 | HOXA2 | O43364 | Homeobox protein Hox-A2 | chr7 | GO:0045665 | Not Cancer Driver | No | 58 | 0.154 | 281 | 48 | 0.171 | 1 |
| ID4 | ID4 | P47928 | DNA-binding protein inhibitor ID-4 | chr6 | GO:0045665 | Not Cancer Driver | No | 4 | 0.025 | 71 | 1 | 0.014 | 0 |
| IRX3 | IRX3 | P78415 | Iroquois-class homeodomain protein IRX-3 | chr16 | GO:0045665 | Not Cancer Driver | No | 38 | 0.076 | 407 | 32 | 0.079 | 0 |
| ISL1 | ISL1 | P61371 | Insulin gene enhancer protein ISL-1 | chr5 | GO:0045665 | Not Cancer Driver | No | 85 | 0.244 | 180 | 41 | 0.228 | 0 |
| ISL2 | ISL2 | Q96A47 | Insulin gene enhancer protein ISL-2 | chr15 | GO:0045665 | Not Cancer Driver | No | 42 | 0.117 | 167 | 16 | 0.096 | 0 |
| JAG1 | JAG1 | P78504 | Protein jagged-1 | chr20 | GO:0045665 | Not Cancer Driver | No | 182 | 0.149 | 172 | 20 | 0.116 | 52 |
| LBX1 | LBX1 | P52954 | Transcription factor LBX1 | chr10 | GO:0045665 | Not Cancer Driver | No | 26 | 0.093 | 181 | 18 | 0.099 | 0 |
| LMX1A_ENST00000294816 | LMX1A | Q8TE12 | LIM homeobox transcription factor 1-alpha | chr1 | GO:0045665 | Not Cancer Driver | No | 117 | 0.306 | 186 | 65 | 0.349 | 1 |
| LSM1 | LSM1 | O15116 | U6 snRNA-associated Sm-like protein LSm1 | chr8 | GO:0045665 | Not Cancer Driver | No | 21 | 0.158 | 6 | 1 | 0.167 | 0 |
| MAG_ENST00000537831 | MAG | P20916 | Myelin-associated glycoprotein | chr19 | GO:0045665 | Not Cancer Driver | No | 118 | 0.188 | 65 | 7 | 0.108 | 1 |
| MED1 | MED1 | Q15648 | Mediator of RNA polymerase II transcription subunit 1 | chr17 | GO:0045665 | Not Cancer Driver | No | 162 | 0.102 | 1104 | 117 | 0.106 | 0 |
| MEIS1 | MEIS1 | O00470 | Homeobox protein Meis1 | chr2 | GO:0045665 | Not Cancer Driver | No | 89 | 0.228 | 267 | 62 | 0.232 | 0 |
| MIB1 | MIB1 | Q86YT6 | E3 ubiquitin-protein ligase MIB1 | chr18 | GO:0045665 | Not Cancer Driver | No | 122 | 0.121 | 282 | 34 | 0.121 | 1 |
| NEPRO | NEPRO | Q6NW34 | Nucleolus and neural progenitor protein | chr3 | GO:0045665 | Not Cancer Driver | No | 62 | 0.109 | 147 | 28 | 0.19 | 0 |
| NKX2-2 | NKX2-2 | O95096 | Homeobox protein Nkx-2.2 | chr20 | GO:0045665 | Not Cancer Driver | No | 84 | 0.308 | 206 | 65 | 0.316 | 0 |
| NOTCH1 | NOTCH1 | P46531 | Neurogenic locus notch homolog protein 1 | chr9 | GO:0045665 | Census, Compendium | Yes | 363 | 0.142 | 686 | 87 | 0.127 | 3 |
| NOTCH3 | NOTCH3 | Q9UM47 | Neurogenic locus notch homolog protein 3 | chr19 | GO:0045665 | Not Cancer Driver | No | 306 | 0.132 | 557 | 81 | 0.145 | 110 |
| NR2E1_ENST00000368986 | NR2E1 | Q9Y466 | Nuclear receptor subfamily 2 group E member 1 | chr6 | GO:0045665 | Not Cancer Driver | No | 75 | 0.195 | 57 | 6 | 0.105 | 0 |
| OLIG2_ENST00000382357 | OLIG2 | Q13516 | Oligodendrocyte transcription factor 2 | chr21 | GO:0045665 | Census | Yes | 37 | 0.115 | 256 | 37 | 0.145 | 0 |
| PAX6_ENST00000241001 | PAX6 | P26367 | Paired box protein Pax-6 | chr11 | GO:0045665 | Not Cancer Driver | No | 72 | 0.171 | 337 | 56 | 0.166 | 38 |
| PBX1 | PBX1 | P40424 | Pre-B-cell leukemia transcription factor 1 | chr1 | GO:0045665 | Census | Yes | 82 | 0.191 | 290 | 57 | 0.197 | 0 |
| PHOX2B | PHOX2B | Q99453 | Paired mesoderm homeobox protein 2B | chr4 | GO:0045665 | Census | Yes | 59 | 0.188 | 219 | 44 | 0.201 | 2 |
| POU4F2 | POU4F2 | Q12837 | POU domain, class 4, transcription factor 2 | chr4 | GO:0045665 | Not Cancer Driver | No | 130 | 0.318 | 308 | 87 | 0.282 | 0 |
| RAP1GAP_ENST00000374765 | RAP1GAP | P47736 | Rap1 GTPase-activating protein 1 | chr1 | GO:0045665 | Not Cancer Driver | No | 81 | 0.122 | 313 | 39 | 0.125 | 0 |
| REST | REST | Q13127 | RE1-silencing transcription factor | chr4 | GO:0045665 | Not Cancer Driver | No | 142 | 0.129 | 868 | 113 | 0.13 | 4 |
| RHOA | RHOA | P61586 | Transforming protein RhoA | chr3 | GO:0045665 | Census, Compendium | Yes | 99 | 0.513 | 46 | 13 | 0.283 | 2 |
| SHH | SHH | Q15465 | Sonic hedgehog protein | chr7 | GO:0045665 | Not Cancer Driver | No | 56 | 0.121 | 139 | 14 | 0.101 | 81 |
| SIX3 | SIX3 | O95343 | Homeobox protein SIX3 | chr2 | GO:0045665 | Not Cancer Driver | No | 44 | 0.133 | 196 | 22 | 0.112 | 32 |
| SLC6A4_ENST00000401766 | SLC6A4 | P31645 | Sodium-dependent serotonin transporter | chr17 | GO:0045665 | Not Cancer Driver | No | 101 | 0.16 | 73 | 12 | 0.164 | 0 |
| SOX2 | SOX2 | P48431 | Transcription factor SOX-2 | chr3 | GO:0045665 | Census | Yes | 39 | 0.123 | 312 | 39 | 0.125 | 0 |
| SOX3 | SOX3 | P41225 | Transcription factor SOX-3 | chrX | GO:0045665 | Not Cancer Driver | No | 63 | 0.141 | 341 | 61 | 0.179 | 0 |
| SOX8 | SOX8 | P57073 | Transcription factor SOX-8 | chr16 | GO:0045665 | Not Cancer Driver | No | 43 | 0.096 | 403 | 39 | 0.097 | 0 |
| SOX9 | SOX9 | P48436 | Transcription factor SOX-9 | chr17 | GO:0045665 | Compendium | Yes | 86 | 0.169 | 495 | 82 | 0.166 | 18 |
| SPAG9 | SPAG9 | O60271 | C-Jun-amino-terminal kinase-interacting protein 4 | chr17 | GO:0045665 | Not Cancer Driver | No | 128 | 0.097 | 841 | 81 | 0.096 | 0 |
| TLX3 | TLX3 | O43711 | T-cell leukemia homeobox protein 3 | chr5 | GO:0045665 | Census | Yes | 40 | 0.137 | 179 | 24 | 0.134 | 0 |
| TP73 | TP73 | O15350 | Tumor protein p73 | chr1 | GO:0045665 | Not Cancer Driver | No | 82 | 0.129 | 443 | 55 | 0.124 | 0 |
| WNT3A | WNT3A | P56704 | Protein Wnt-3a | chr1 | GO:0045665 | Not Cancer Driver | No | 77 | 0.219 | 37 | 5 | 0.135 | 0 |
| ZHX2 | ZHX2 | Q9Y6X8 | Zinc fingers and homeoboxes protein 2 | chr8 | GO:0045665 | Not Cancer Driver | No | 151 | 0.18 | 593 | 103 | 0.174 | 0 |
| ZNF536 | ZNF536 | O15090 | Zinc finger protein 536 | chr19 | GO:0045665 | Not Cancer Driver | No | 596 | 0.458 | 991 | 445 | 0.449 | 0 |