Total number of protein in "GO:0045664" GO term: 65
| Identifier | UniProt Gene | UniProt Accession | UniProt Name | Chromosome | GO term | Database | Cancer Driver | Number of missense mutations | Missense mutation per residues | Number of disordered residues | Number of mutations in disordered regions | Disordered missense mutations per residues | Number of OMIM mutation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ALK | ALK | Q9UM73 | ALK tyrosine kinase receptor | chr2 | GO:0045664 | Census, Compendium | Yes | 303 | 0.187 | 575 | 114 | 0.198 | 16 |
| ASCL1 | ASCL1 | P50553 | Achaete-scute homolog 1 | chr12 | GO:0045664 | Not Cancer Driver | No | 33 | 0.14 | 182 | 24 | 0.132 | 0 |
| ATOH1 | ATOH1 | Q92858 | Transcription factor ATOH1 | chr4 | GO:0045664 | Not Cancer Driver | No | 63 | 0.178 | 327 | 55 | 0.168 | 0 |
| B2M | B2M | P61769 | Beta-2-microglobulin | chr15 | GO:0045664 | Census, Compendium | Yes | 34 | 0.286 | 5 | 1 | 0.2 | 2 |
| BCL11A | BCL11A | Q9H165 | B-cell lymphoma/leukemia 11A | chr2 | GO:0045664 | Census, Compendium | Yes | 210 | 0.251 | 677 | 171 | 0.253 | 3 |
| BCL11B | BCL11B | Q9C0K0 | B-cell lymphoma/leukemia 11B | chr14 | GO:0045664 | Census, Compendium | Yes | 156 | 0.174 | 699 | 114 | 0.163 | 2 |
| BCL2_ENST00000333681 | BCL2 | P10415 | Apoptosis regulator Bcl-2 | chr18 | GO:0045664 | Census, Compendium | Yes | 24 | 0.1 | 72 | 5 | 0.069 | 0 |
| BDNF_ENST00000439476 | BDNF | P23560 | Brain-derived neurotrophic factor | chr11 | GO:0045664 | Not Cancer Driver | No | 47 | 0.19 | 79 | 19 | 0.241 | 1 |
| BIN1 | BIN1 | O00499 | Myc box-dependent-interacting protein 1 | chr2 | GO:0045664 | Not Cancer Driver | No | 65 | 0.11 | 456 | 42 | 0.092 | 5 |
| CASZ1 | CASZ1 | Q86V15 | Zinc finger protein castor homolog 1 | chr1 | GO:0045664 | Compendium | Yes | 237 | 0.135 | 1077 | 152 | 0.141 | 0 |
| CDK5R1 | CDK5R1 | Q15078 | Cyclin-dependent kinase 5 activator 1 | chr17 | GO:0045664 | Not Cancer Driver | No | 35 | 0.114 | 103 | 16 | 0.155 | 0 |
| CDK5RAP1_ENST00000357886 | CDK5RAP1 | Q96SZ6 | Mitochondrial tRNA methylthiotransferase CDK5RAP1 | chr20 | GO:0045664 | Not Cancer Driver | No | 73 | 0.121 | 95 | 12 | 0.126 | 0 |
| CDK5RAP2 | CDK5RAP2 | Q96SN8 | CDK5 regulatory subunit-associated protein 2 | chr9 | GO:0045664 | Not Cancer Driver | No | 217 | 0.115 | 1136 | 128 | 0.113 | 0 |
| CDK5RAP3_ENST00000338399 | CDK5RAP3 | Q96JB5 | CDK5 regulatory subunit-associated protein 3 | chr17 | GO:0045664 | Not Cancer Driver | No | 50 | 0.099 | 99 | 20 | 0.202 | 0 |
| CDON | CDON | Q4KMG0 | Cell adhesion molecule-related/down-regulated by oncogenes | chr11 | GO:0045664 | Not Cancer Driver | No | 183 | 0.142 | 441 | 63 | 0.143 | 5 |
| CNTF | CNTF | P26441 | Ciliary neurotrophic factor | chr11 | GO:0045664 | Not Cancer Driver | No | 41 | 0.205 | 34 | 5 | 0.147 | 0 |
| CSNK1D | CSNK1D | P48730 | Casein kinase I isoform delta | chr17 | GO:0045664 | Not Cancer Driver | No | 59 | 0.142 | 132 | 16 | 0.121 | 2 |
| CSNK1E | CSNK1E | P49674 | Casein kinase I isoform epsilon | chr22 | GO:0045664 | Not Cancer Driver | No | 62 | 0.149 | 133 | 18 | 0.135 | 0 |
| DKK1 | DKK1 | O94907 | Dickkopf-related protein 1 | chr10 | GO:0045664 | Not Cancer Driver | No | 58 | 0.218 | 47 | 8 | 0.17 | 0 |
| DLL1 | DLL1 | O00548 | Delta-like protein 1 | chr6 | GO:0045664 | Not Cancer Driver | No | 115 | 0.159 | 145 | 24 | 0.166 | 1 |
| DLX1 | DLX1 | P56177 | Homeobox protein DLX-1 | chr2 | GO:0045664 | Not Cancer Driver | No | 25 | 0.098 | 183 | 21 | 0.115 | 0 |
| DLX2 | DLX2 | Q07687 | Homeobox protein DLX-2 | chr2 | GO:0045664 | Not Cancer Driver | No | 46 | 0.14 | 262 | 38 | 0.145 | 0 |
| DPYSL2_ENST00000311151 | DPYSL2 | Q16555 | Dihydropyrimidinase-related protein 2 | chr8 | GO:0045664 | Not Cancer Driver | No | 86 | 0.15 | 146 | 32 | 0.219 | 0 |
| EDNRB_ENST00000334286 | EDNRB | P24530 | Endothelin receptor type B | chr13 | GO:0045664 | Not Cancer Driver | No | 112 | 0.253 | 56 | 19 | 0.339 | 6 |
| ESRP1_ENST00000642581 | ESRP1 | Q6NXG1 | Epithelial splicing regulatory protein 1 | chr8 | GO:0045664 | Not Cancer Driver | No | 120 | 0.176 | 41 | 5 | 0.122 | 1 |
| EYA1_ENST00000647540 | EYA1 | Q99502 | Eyes absent homolog 1 | chr8 | GO:0045664 | Not Cancer Driver | No | 168 | 0.284 | 341 | 99 | 0.29 | 15 |
| FGF20 | FGF20 | Q9NP95 | Fibroblast growth factor 20 | chr8 | GO:0045664 | Not Cancer Driver | No | 25 | 0.118 | 57 | 3 | 0.053 | 0 |
| GATA2_ENST00000487848 | GATA2 | P23769 | Endothelial transcription factor GATA-2 | chr3 | GO:0045664 | Census, Compendium | Yes | 72 | 0.15 | 370 | 49 | 0.132 | 6 |
| GSK3B_ENST00000264235 | GSK3B | P49841 | Glycogen synthase kinase-3 beta | chr3 | GO:0045664 | Not Cancer Driver | No | 56 | 0.133 | 146 | 13 | 0.089 | 0 |
| HES1 | HES1 | Q14469 | Transcription factor HES-1 | chr3 | GO:0045664 | Not Cancer Driver | No | 37 | 0.132 | 226 | 32 | 0.142 | 0 |
| HES5 | HES5 | Q5TA89 | Transcription factor HES-5 | chr1 | GO:0045664 | Not Cancer Driver | No | 1 | 0.006 | 73 | 0 | 0.0 | 0 |
| HEY2 | HEY2 | Q9UBP5 | Hairy/enhancer-of-split related with YRPW motif protein 2 | chr6 | GO:0045664 | Not Cancer Driver | No | 64 | 0.19 | 179 | 26 | 0.145 | 0 |
| ID2_ENST00000396290 | ID2 | Q02363 | DNA-binding protein inhibitor ID-2 | chr2 | GO:0045664 | Not Cancer Driver | No | 14 | 0.104 | 52 | 7 | 0.135 | 0 |
| LRRK2 | LRRK2 | Q5S007 | Leucine-rich repeat serine/threonine-protein kinase 2 | chr12 | GO:0045664 | Not Cancer Driver | No | 519 | 0.205 | 90 | 17 | 0.189 | 23 |
| LTK | LTK | P29376 | Leukocyte tyrosine kinase receptor | chr15 | GO:0045664 | Not Cancer Driver | No | 103 | 0.119 | 301 | 30 | 0.1 | 0 |
| MAP3K13_ENST00000424227 | MAP3K13 | O43283 | Mitogen-activated protein kinase kinase kinase 13 | chr3 | GO:0045664 | Census | Yes | 157 | 0.163 | 593 | 91 | 0.153 | 0 |
| MOSMO | MOSMO | Q8NHV5 | Modulator of smoothened protein | chr16 | GO:0045664 | Not Cancer Driver | No | 3 | 0.018 | 0 | 0 | 0.0 | 0 |
| MYCL_ENST00000372816 | MYCL | P12524 | Protein L-Myc | chr1 | GO:0045664 | Census | Yes | 47 | 0.129 | 275 | 43 | 0.156 | 0 |
| NGF | NGF | P01138 | Beta-nerve growth factor | chr1 | GO:0045664 | Not Cancer Driver | No | 66 | 0.274 | 93 | 25 | 0.269 | 1 |
| NLGN1_ENST00000361589 | NLGN1 | Q8N2Q7 | Neuroligin-1 | chr3 | GO:0045664 | Not Cancer Driver | No | 214 | 0.248 | 248 | 61 | 0.246 | 4 |
| NOTCH1 | NOTCH1 | P46531 | Neurogenic locus notch homolog protein 1 | chr9 | GO:0045664 | Census, Compendium | Yes | 363 | 0.142 | 686 | 87 | 0.127 | 3 |
| NR2E1_ENST00000368986 | NR2E1 | Q9Y466 | Nuclear receptor subfamily 2 group E member 1 | chr6 | GO:0045664 | Not Cancer Driver | No | 75 | 0.195 | 57 | 6 | 0.105 | 0 |
| NREP_ENST00000447165 | NREP | Q16612 | Neuronal regeneration-related protein | chr5 | GO:0045664 | Not Cancer Driver | No | 17 | 0.25 | 36 | 13 | 0.361 | 0 |
| NTF3_ENST00000331010 | NTF3 | P20783 | Neurotrophin-3 | chr12 | GO:0045664 | Not Cancer Driver | No | 52 | 0.202 | 99 | 21 | 0.212 | 0 |
| NTF4 | NTF4 | P34130 | Neurotrophin-4 | chr19 | GO:0045664 | Not Cancer Driver | No | 21 | 0.1 | 56 | 4 | 0.071 | 0 |
| POU4F2 | POU4F2 | Q12837 | POU domain, class 4, transcription factor 2 | chr4 | GO:0045664 | Not Cancer Driver | No | 130 | 0.318 | 308 | 87 | 0.282 | 0 |
| PROX1 | PROX1 | Q92786 | Prospero homeobox protein 1 | chr1 | GO:0045664 | Not Cancer Driver | No | 182 | 0.247 | 537 | 141 | 0.263 | 0 |
| RAC3 | RAC3 | P60763 | Ras-related C3 botulinum toxin substrate 3 | chr17 | GO:0045664 | Not Cancer Driver | No | 24 | 0.125 | 0 | 0 | 0.0 | 4 |
| RET | RET | P07949 | Proto-oncogene tyrosine-protein kinase receptor Ret | chr10 | GO:0045664 | Census, Compendium | Yes | 208 | 0.187 | 105 | 12 | 0.114 | 139 |
| ROCK1 | ROCK1 | Q13464 | Rho-associated protein kinase 1 | chr18 | GO:0045664 | Not Cancer Driver | No | 184 | 0.136 | 780 | 103 | 0.132 | 0 |
| S1PR5_ENST00000439028 | S1PR5 | Q9H228 | Sphingosine 1-phosphate receptor 5 | chr19 | GO:0045664 | Not Cancer Driver | No | 39 | 0.098 | 68 | 11 | 0.162 | 0 |
| SFRP1 | SFRP1 | Q8N474 | Secreted frizzled-related protein 1 | chr8 | GO:0045664 | Not Cancer Driver | No | 40 | 0.127 | 39 | 7 | 0.179 | 0 |
| SFRP2 | SFRP2 | Q96HF1 | Secreted frizzled-related protein 2 | chr4 | GO:0045664 | Not Cancer Driver | No | 47 | 0.159 | 1 | 0 | 0.0 | 0 |
| SHH | SHH | Q15465 | Sonic hedgehog protein | chr7 | GO:0045664 | Not Cancer Driver | No | 56 | 0.121 | 139 | 14 | 0.101 | 81 |
| SIX1_ENST00000645694 | SIX1 | Q15475 | Homeobox protein SIX1 | chr14 | GO:0045664 | Census, Compendium | Yes | 49 | 0.173 | 144 | 25 | 0.174 | 8 |
| SOX8 | SOX8 | P57073 | Transcription factor SOX-8 | chr16 | GO:0045664 | Not Cancer Driver | No | 43 | 0.096 | 403 | 39 | 0.097 | 0 |
| SOX9 | SOX9 | P48436 | Transcription factor SOX-9 | chr17 | GO:0045664 | Compendium | Yes | 86 | 0.169 | 495 | 82 | 0.166 | 18 |
| TBX6 | TBX6 | O95947 | T-box transcription factor TBX6 | chr16 | GO:0045664 | Not Cancer Driver | No | 44 | 0.101 | 253 | 25 | 0.099 | 0 |
| TIAM1 | TIAM1 | Q13009 | Rho guanine nucleotide exchange factor TIAM1 | chr21 | GO:0045664 | Not Cancer Driver | No | 370 | 0.233 | 810 | 194 | 0.24 | 0 |
| WDR62_ENST00000270301 | WDR62 | O43379 | WD repeat-containing protein 62 | chr19 | GO:0045664 | Not Cancer Driver | No | 181 | 0.119 | 792 | 100 | 0.126 | 5 |
| WNT3A | WNT3A | P56704 | Protein Wnt-3a | chr1 | GO:0045664 | Not Cancer Driver | No | 77 | 0.219 | 37 | 5 | 0.135 | 0 |
| YWHAG | YWHAG | P61981 | 14-3-3 protein gamma | chr7 | GO:0045664 | Not Cancer Driver | No | 26 | 0.105 | 77 | 9 | 0.117 | 2 |
| YWHAH | YWHAH | Q04917 | 14-3-3 protein eta | chr22 | GO:0045664 | Not Cancer Driver | No | 15 | 0.061 | 55 | 3 | 0.055 | 0 |
| ZFHX2 | ZFHX2 | Q9C0A1 | Zinc finger homeobox protein 2 | chr14 | GO:0045664 | Not Cancer Driver | No | 52 | 0.02 | 1914 | 43 | 0.022 | 1 |
| ZFHX3_ENST00000268489 | ZFHX3 | Q15911 | Zinc finger homeobox protein 3 | chr16 | GO:0045664 | Census, Compendium | Yes | 501 | 0.135 | 2555 | 337 | 0.132 | 0 |