Total number of protein in "GO:0045582" GO term: 93
| Identifier | UniProt Gene | UniProt Accession | UniProt Name | Chromosome | GO term | Database | Cancer Driver | Number of missense mutations | Missense mutation per residues | Number of disordered residues | Number of mutations in disordered regions | Disordered missense mutations per residues | Number of OMIM mutation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ADA | ADA | P00813 | Adenosine deaminase | chr20 | GO:0045582 | Not Cancer Driver | No | 50 | 0.138 | 44 | 9 | 0.205 | 27 |
| ADAM8 | ADAM8 | P78325 | Disintegrin and metalloproteinase domain-containing protein 8 | chr10 | GO:0045582 | Not Cancer Driver | No | 82 | 0.1 | 230 | 13 | 0.057 | 0 |
| AMBRA1_ENST00000458649 | AMBRA1 | Q9C0C7 | Activating molecule in BECN1-regulated autophagy protein 1 | chr11 | GO:0045582 | Not Cancer Driver | No | 173 | 0.133 | 788 | 103 | 0.131 | 0 |
| ANXA1_ENST00000257497 | ANXA1 | P04083 | Annexin A1 | chr9 | GO:0045582 | Not Cancer Driver | No | 59 | 0.171 | 61 | 12 | 0.197 | 0 |
| AP3B1 | AP3B1 | O00203 | AP-3 complex subunit beta-1 | chr5 | GO:0045582 | Not Cancer Driver | No | 126 | 0.115 | 316 | 31 | 0.098 | 1 |
| AP3D1_ENST00000345016 | AP3D1 | O14617 | AP-3 complex subunit delta-1 | chr19 | GO:0045582 | Not Cancer Driver | No | 138 | 0.12 | 404 | 59 | 0.146 | 0 |
| BAD_ENST00000309032 | BAD | Q92934 | Bcl2-associated agonist of cell death | chr11 | GO:0045582 | Not Cancer Driver | No | 14 | 0.083 | 163 | 14 | 0.086 | 0 |
| BCL6_ENST00000232014 | BCL6 | P41182 | B-cell lymphoma 6 protein | chr3 | GO:0045582 | Census, Compendium | Yes | 134 | 0.19 | 328 | 67 | 0.204 | 0 |
| BTN2A2 | BTN2A2 | Q8WVV5 | Butyrophilin subfamily 2 member A2 | chr6 | GO:0045582 | Not Cancer Driver | No | 92 | 0.176 | 24 | 2 | 0.083 | 0 |
| CBFB_ENST00000290858 | CBFB | Q13951 | Core-binding factor subunit beta | chr16 | GO:0045582 | Census, Compendium | Yes | 39 | 0.214 | 94 | 17 | 0.181 | 0 |
| CCL19 | CCL19 | Q99731 | C-C motif chemokine 19 | chr9 | GO:0045582 | Not Cancer Driver | No | 10 | 0.102 | 7 | 0 | 0.0 | 0 |
| CD27 | CD27 | P26842 | CD27 antigen | chr12 | GO:0045582 | Not Cancer Driver | No | 30 | 0.115 | 92 | 11 | 0.12 | 1 |
| CD46_ENST00000358170 | CD46 | P15529 | Membrane cofactor protein | chr1 | GO:0045582 | Not Cancer Driver | No | 53 | 0.135 | 52 | 4 | 0.077 | 5 |
| CD74 | CD74 | P04233 | HLA class II histocompatibility antigen gamma chain | chr5 | GO:0045582 | Census | Yes | 31 | 0.105 | 185 | 20 | 0.108 | 0 |
| CD80_ENST00000478182 | CD80 | P33681 | T-lymphocyte activation antigen CD80 | chr3 | GO:0045582 | Not Cancer Driver | No | 50 | 0.174 | 26 | 5 | 0.192 | 0 |
| CD83 | CD83 | Q01151 | CD83 antigen | chr6 | GO:0045582 | Not Cancer Driver | No | 24 | 0.117 | 48 | 8 | 0.167 | 0 |
| CD86 | CD86 | P42081 | T-lymphocyte activation antigen CD86 | chr3 | GO:0045582 | Not Cancer Driver | No | 90 | 0.274 | 56 | 18 | 0.321 | 0 |
| CR1_ENST00000367053 | CR1 | P17927 | Complement receptor type 1 | chr1 | GO:0045582 | Compendium | Yes | 383 | 0.188 | 151 | 42 | 0.278 | 0 |
| DUSP10 | DUSP10 | Q9Y6W6 | Dual specificity protein phosphatase 10 | chr1 | GO:0045582 | Not Cancer Driver | No | 81 | 0.168 | 135 | 24 | 0.178 | 0 |
| EGR3 | EGR3 | Q06889 | Early growth response protein 3 | chr8 | GO:0045582 | Not Cancer Driver | No | 60 | 0.155 | 252 | 46 | 0.183 | 0 |
| FOXO3 | FOXO3 | O43524 | Forkhead box protein O3 | chr6 | GO:0045582 | Census, Compendium | Yes | 70 | 0.104 | 595 | 68 | 0.114 | 0 |
| FOXP3 | FOXP3 | Q9BZS1 | Forkhead box protein P3 | chrX | GO:0045582 | Not Cancer Driver | No | 38 | 0.088 | 186 | 16 | 0.086 | 10 |
| GATA3_ENST00000346208 | GATA3 | P23771 | Trans-acting T-cell-specific transcription factor GATA-3 | chr10 | GO:0045582 | Census, Compendium | Yes | 111 | 0.251 | 364 | 87 | 0.239 | 2 |
| GLI2_ENST00000361492 | GLI2 | P10070 | Zinc finger protein GLI2 | chr2 | GO:0045582 | Not Cancer Driver | No | 287 | 0.181 | 1403 | 244 | 0.174 | 2 |
| GLI3 | GLI3 | P10071 | Transcriptional activator GLI3 | chr7 | GO:0045582 | Not Cancer Driver | No | 385 | 0.244 | 1352 | 327 | 0.242 | 7 |
| HLA-DRA | HLA-DRA | P01903 | HLA class II histocompatibility antigen, DR alpha chain | chr6 | GO:0045582 | Not Cancer Driver | No | 52 | 0.205 | 12 | 1 | 0.083 | 0 |
| HLA-DRB1 | HLA-DRB1 | P01911 | HLA class II histocompatibility antigen, DRB1 beta chain | chr6 | GO:0045582 | Not Cancer Driver | No | 48 | 0.18 | 12 | 1 | 0.083 | 0 |
| HLA-G_ENST00000360323 | HLA-G | P17693 | HLA class I histocompatibility antigen, alpha chain G | chr6 | GO:0045582 | Not Cancer Driver | No | 94 | 0.278 | 85 | 22 | 0.259 | 0 |
| HLX | HLX | Q14774 | H2.0-like homeobox protein | chr1 | GO:0045582 | Not Cancer Driver | No | 107 | 0.219 | 412 | 98 | 0.238 | 0 |
| IFNG | IFNG | P01579 | Interferon gamma | chr12 | GO:0045582 | Not Cancer Driver | No | 51 | 0.307 | 23 | 6 | 0.261 | 0 |
| IHH | IHH | Q14623 | Indian hedgehog protein | chr2 | GO:0045582 | Not Cancer Driver | No | 58 | 0.141 | 111 | 15 | 0.135 | 6 |
| IL12B | IL12B | P29460 | Interleukin-12 subunit beta | chr5 | GO:0045582 | Not Cancer Driver | No | 48 | 0.146 | 42 | 2 | 0.048 | 0 |
| IL12RB1_ENST00000593993 | IL12RB1 | P42701 | Interleukin-12 receptor subunit beta-1 | chr19 | GO:0045582 | Not Cancer Driver | No | 108 | 0.163 | 207 | 38 | 0.184 | 1 |
| IL18 | IL18 | Q14116 | Interleukin-18 | chr11 | GO:0045582 | Not Cancer Driver | No | 19 | 0.098 | 16 | 3 | 0.188 | 0 |
| IL1RL2 | IL1RL2 | Q9HB29 | Interleukin-1 receptor-like 2 | chr2 | GO:0045582 | Not Cancer Driver | No | 114 | 0.198 | 11 | 4 | 0.364 | 0 |
| IL2 | IL2 | P60568 | Interleukin-2 | chr4 | GO:0045582 | Census | Yes | 24 | 0.157 | 6 | 1 | 0.167 | 0 |
| IL23A | IL23A | Q9NPF7 | Interleukin-23 subunit alpha | chr12 | GO:0045582 | Not Cancer Driver | No | 15 | 0.079 | 42 | 3 | 0.071 | 0 |
| IL23R | IL23R | Q5VWK5 | Interleukin-23 receptor | chr1 | GO:0045582 | Not Cancer Driver | No | 70 | 0.111 | 117 | 19 | 0.162 | 0 |
| IL2RA | IL2RA | P01589 | Interleukin-2 receptor subunit alpha | chr10 | GO:0045582 | Not Cancer Driver | No | 51 | 0.188 | 131 | 29 | 0.221 | 2 |
| IL36B | IL36B | Q9NZH7 | Interleukin-36 beta | chr2 | GO:0045582 | Not Cancer Driver | No | 53 | 0.323 | 32 | 8 | 0.25 | 0 |
| IL4 | IL4 | P05112 | Interleukin-4 | chr5 | GO:0045582 | Not Cancer Driver | No | 18 | 0.118 | 0 | 0 | 0.0 | 0 |
| IL4I1_ENST00000391826 | IL4I1 | Q96RQ9 | L-amino-acid oxidase | chr19 | GO:0045582 | Not Cancer Driver | No | 65 | 0.115 | 136 | 14 | 0.103 | 0 |
| IL4R_ENST00000543915 | IL4R | P24394 | Interleukin-4 receptor subunit alpha | chr16 | GO:0045582 | Not Cancer Driver | No | 133 | 0.161 | 420 | 64 | 0.152 | 0 |
| IL7 | IL7 | P13232 | Interleukin-7 | chr8 | GO:0045582 | Not Cancer Driver | No | 29 | 0.164 | 19 | 4 | 0.211 | 0 |
| IL7R | IL7R | P16871 | Interleukin-7 receptor subunit alpha | chr5 | GO:0045582 | Census, Compendium | Yes | 177 | 0.386 | 88 | 48 | 0.545 | 1 |
| ITPKB_ENST00000272117 | ITPKB | P27987 | Inositol-trisphosphate 3-kinase B | chr1 | GO:0045582 | Not Cancer Driver | No | 148 | 0.156 | 719 | 119 | 0.166 | 0 |
| LEF1 | LEF1 | Q9UJU2 | Lymphoid enhancer-binding factor 1 | chr4 | GO:0045582 | Census | Yes | 64 | 0.16 | 370 | 57 | 0.154 | 0 |
| LGALS9 | LGALS9 | O00182 | Galectin-9 | chr17 | GO:0045582 | Not Cancer Driver | No | 54 | 0.152 | 65 | 16 | 0.246 | 0 |
| LILRB2_ENST00000314446 | LILRB2 | Q8N423 | Leukocyte immunoglobulin-like receptor subfamily B member 2 | chr19 | GO:0045582 | Not Cancer Driver | No | 148 | 0.248 | 235 | 50 | 0.213 | 0 |
| LILRB4 | LILRB4 | Q8NHJ6 | Leukocyte immunoglobulin-like receptor subfamily B member 4 | chr19 | GO:0045582 | Not Cancer Driver | No | 162 | 0.362 | 277 | 115 | 0.415 | 0 |
| MALT1 | MALT1 | Q9UDY8 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | chr18 | GO:0045582 | Census, Compendium | Yes | 75 | 0.091 | 139 | 12 | 0.086 | 1 |
| MDK_ENST00000407067 | MDK | P21741 | Midkine | chr11 | GO:0045582 | Not Cancer Driver | No | 15 | 0.105 | 20 | 2 | 0.1 | 0 |
| MYB_ENST00000367814 | MYB | P10242 | Transcriptional activator Myb | chr6 | GO:0045582 | Census | Yes | 82 | 0.128 | 528 | 69 | 0.131 | 0 |
| NCKAP1L | NCKAP1L | P55160 | Nck-associated protein 1-like | chr12 | GO:0045582 | Not Cancer Driver | No | 247 | 0.219 | 51 | 10 | 0.196 | 4 |
| NFKBID | NFKBID | Q8NI38 | NF-kappa-B inhibitor delta | chr19 | GO:0045582 | Not Cancer Driver | No | 47 | 0.15 | 124 | 20 | 0.161 | 0 |
| NFKBIZ | NFKBIZ | Q9BYH8 | NF-kappa-B inhibitor zeta | chr3 | GO:0045582 | Not Cancer Driver | No | 96 | 0.134 | 443 | 53 | 0.12 | 0 |
| NKAP | NKAP | Q8N5F7 | NF-kappa-B-activating protein | chrX | GO:0045582 | Not Cancer Driver | No | 80 | 0.193 | 409 | 77 | 0.188 | 3 |
| NLRP3_ENST00000391828 | NLRP3 | Q96P20 | NACHT, LRR and PYD domains-containing protein 3 | chr1 | GO:0045582 | Not Cancer Driver | No | 339 | 0.327 | 64 | 33 | 0.516 | 37 |
| PCK1 | PCK1 | P35558 | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | chr20 | GO:0045582 | Not Cancer Driver | No | 142 | 0.228 | 110 | 28 | 0.255 | 1 |
| PIK3R6_ENST00000614407 | PIK3R6 | Q5UE93 | Phosphoinositide 3-kinase regulatory subunit 6 | chr17 | GO:0045582 | Not Cancer Driver | No | 100 | 0.133 | 156 | 26 | 0.167 | 0 |
| PNP | PNP | P00491 | Purine nucleoside phosphorylase | chr14 | GO:0045582 | Not Cancer Driver | No | 38 | 0.131 | 29 | 2 | 0.069 | 5 |
| PRKCZ | PRKCZ | Q05513 | Protein kinase C zeta type | chr1 | GO:0045582 | Not Cancer Driver | No | 70 | 0.118 | 116 | 11 | 0.095 | 0 |
| PTPRC | PTPRC | P08575 | Receptor-type tyrosine-protein phosphatase C | chr1 | GO:0045582 | Census, Compendium | Yes | 315 | 0.241 | 462 | 107 | 0.232 | 0 |
| RAG1 | RAG1 | P15918 | V(D)J recombination-activating protein 1 | chr11 | GO:0045582 | Not Cancer Driver | No | 204 | 0.196 | 208 | 43 | 0.207 | 36 |
| RARA | RARA | P10276 | Retinoic acid receptor alpha | chr17 | GO:0045582 | Census, Compendium | Yes | 70 | 0.152 | 167 | 14 | 0.084 | 0 |
| RASGRP1 | RASGRP1 | O95267 | RAS guanyl-releasing protein 1 | chr15 | GO:0045582 | Not Cancer Driver | No | 96 | 0.12 | 191 | 12 | 0.063 | 1 |
| RHOA | RHOA | P61586 | Transforming protein RhoA | chr3 | GO:0045582 | Census, Compendium | Yes | 99 | 0.513 | 46 | 13 | 0.283 | 2 |
| RHOH_ENST00000617441 | RHOH | Q15669 | Rho-related GTP-binding protein RhoH | chr4 | GO:0045582 | Census | Yes | 41 | 0.215 | 12 | 3 | 0.25 | 0 |
| RIPK2 | RIPK2 | O43353 | Receptor-interacting serine/threonine-protein kinase 2 | chr8 | GO:0045582 | Not Cancer Driver | No | 63 | 0.117 | 143 | 20 | 0.14 | 0 |
| RUNX1_ENST00000344691 | RUNX1 | Q01196 | Runt-related transcription factor 1 | chr21 | GO:0045582 | Census, Compendium | Yes | 81 | 0.179 | 360 | 58 | 0.161 | 2 |
| RUNX3_ENST00000308873 | RUNX3 | Q13761 | Runt-related transcription factor 3 | chr1 | GO:0045582 | Not Cancer Driver | No | 59 | 0.142 | 331 | 45 | 0.136 | 0 |
| SART1 | SART1 | O43290 | U4/U6.U5 tri-snRNP-associated protein 1 | chr11 | GO:0045582 | Not Cancer Driver | No | 71 | 0.089 | 685 | 63 | 0.092 | 0 |
| SASH3 | SASH3 | O75995 | SAM and SH3 domain-containing protein 3 | chrX | GO:0045582 | Not Cancer Driver | No | 59 | 0.155 | 327 | 49 | 0.15 | 0 |
| SHH | SHH | Q15465 | Sonic hedgehog protein | chr7 | GO:0045582 | Not Cancer Driver | No | 56 | 0.121 | 139 | 14 | 0.101 | 81 |
| SOCS1 | SOCS1 | O15524 | Suppressor of cytokine signaling 1 | chr16 | GO:0045582 | Census, Compendium | Yes | 22 | 0.104 | 66 | 3 | 0.045 | 2 |
| SOCS5 | SOCS5 | O75159 | Suppressor of cytokine signaling 5 | chr2 | GO:0045582 | Not Cancer Driver | No | 84 | 0.157 | 297 | 46 | 0.155 | 0 |
| SOX12 | SOX12 | O15370 | Transcription factor SOX-12 | chr20 | GO:0045582 | Not Cancer Driver | No | 20 | 0.063 | 307 | 19 | 0.062 | 0 |
| SOX13 | SOX13 | Q9UN79 | Transcription factor SOX-13 | chr1 | GO:0045582 | Not Cancer Driver | No | 85 | 0.137 | 564 | 77 | 0.137 | 0 |
| SOX4 | SOX4 | Q06945 | Transcription factor SOX-4 | chr6 | GO:0045582 | Not Cancer Driver | No | 28 | 0.059 | 400 | 24 | 0.06 | 4 |
| STAT5B | STAT5B | P51692 | Signal transducer and activator of transcription 5B | chr17 | GO:0045582 | Census, Compendium | Yes | 93 | 0.118 | 144 | 19 | 0.132 | 5 |
| SYK_ENST00000375746 | SYK | P43405 | Tyrosine-protein kinase SYK | chr9 | GO:0045582 | Census | Yes | 96 | 0.151 | 131 | 27 | 0.206 | 5 |
| TESPA1 | TESPA1 | A2RU30 | Protein TESPA1 | chr12 | GO:0045582 | Not Cancer Driver | No | 127 | 0.244 | 284 | 84 | 0.296 | 0 |
| TGFBR2_ENST00000295754 | TGFBR2 | P37173 | TGF-beta receptor type-2 | chr3 | GO:0045582 | Census, Compendium | Yes | 106 | 0.187 | 60 | 16 | 0.267 | 25 |
| TNFSF4 | TNFSF4 | P23510 | Tumor necrosis factor ligand superfamily member 4 | chr1 | GO:0045582 | Not Cancer Driver | No | 28 | 0.153 | 1 | 0 | 0.0 | 0 |
| TNFSF9 | TNFSF9 | P41273 | Tumor necrosis factor ligand superfamily member 9 | chr19 | GO:0045582 | Not Cancer Driver | No | 32 | 0.126 | 39 | 4 | 0.103 | 0 |
| VNN1 | VNN1 | O95497 | Pantetheinase | chr6 | GO:0045582 | Not Cancer Driver | No | 88 | 0.172 | 20 | 5 | 0.25 | 0 |
| VSIR | VSIR | Q9H7M9 | V-type immunoglobulin domain-containing suppressor of T-cell activation | chr10 | GO:0045582 | Not Cancer Driver | No | 52 | 0.167 | 135 | 19 | 0.141 | 0 |
| XBP1 | XBP1 | P17861 | X-box-binding protein 1 | chr22 | GO:0045582 | Not Cancer Driver | No | 19 | 0.073 | 169 | 9 | 0.053 | 0 |
| ZAP70 | ZAP70 | P43403 | Tyrosine-protein kinase ZAP-70 | chr2 | GO:0045582 | Not Cancer Driver | No | 126 | 0.204 | 117 | 17 | 0.145 | 8 |
| ZBTB1 | ZBTB1 | Q9Y2K1 | Zinc finger and BTB domain-containing protein 1 | chr14 | GO:0045582 | Not Cancer Driver | No | 70 | 0.098 | 271 | 27 | 0.1 | 0 |
| ZBTB16_ENST00000392996 | ZBTB16 | Q05516 | Zinc finger and BTB domain-containing protein 16 | chr11 | GO:0045582 | Census, Compendium | Yes | 131 | 0.195 | 268 | 50 | 0.187 | 1 |
| ZBTB7B_ENST00000368426 | ZBTB7B | O15156 | Zinc finger and BTB domain-containing protein 7B | chr1 | GO:0045582 | Compendium | Yes | 103 | 0.191 | 353 | 70 | 0.198 | 0 |
| ZMIZ1 | ZMIZ1 | Q9ULJ6 | Zinc finger MIZ domain-containing protein 1 | chr10 | GO:0045582 | Not Cancer Driver | No | 148 | 0.139 | 762 | 111 | 0.146 | 5 |