Total number of protein in "GO:0045444" GO term: 105
| Identifier | UniProt Gene | UniProt Accession | UniProt Name | Chromosome | GO term | Database | Cancer Driver | Number of missense mutations | Missense mutation per residues | Number of disordered residues | Number of mutations in disordered regions | Disordered missense mutations per residues | Number of OMIM mutation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ADGRF5_ENST00000265417 | ADGRF5 | Q8IZF2 | Adhesion G protein-coupled receptor F5 | chr6 | GO:0045444 | Not Cancer Driver | No | 255 | 0.189 | 53 | 11 | 0.208 | 0 |
| ADIG | ADIG | Q0VDE8 | Adipogenin | chr20 | GO:0045444 | Not Cancer Driver | No | 18 | 0.225 | 0 | 0 | 0.0 | 0 |
| ADIPOQ | ADIPOQ | Q15848 | Adiponectin | chr3 | GO:0045444 | Not Cancer Driver | No | 39 | 0.16 | 92 | 21 | 0.228 | 1 |
| ADRB1 | ADRB1 | P08588 | Beta-1 adrenergic receptor | chr10 | GO:0045444 | Not Cancer Driver | No | 35 | 0.073 | 116 | 1 | 0.009 | 0 |
| ADRB2 | ADRB2 | P07550 | Beta-2 adrenergic receptor | chr5 | GO:0045444 | Not Cancer Driver | No | 52 | 0.126 | 35 | 4 | 0.114 | 0 |
| AKT2 | AKT2 | P31751 | RAC-beta serine/threonine-protein kinase | chr19 | GO:0045444 | Census | Yes | 77 | 0.16 | 84 | 9 | 0.107 | 2 |
| ALDH6A1 | ALDH6A1 | Q02252 | Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial | chr14 | GO:0045444 | Not Cancer Driver | No | 54 | 0.101 | 83 | 11 | 0.133 | 1 |
| ALOXE3_ENST00000448843 | ALOXE3 | Q9BYJ1 | Hydroperoxide isomerase ALOXE3 | chr17 | GO:0045444 | Not Cancer Driver | No | 108 | 0.152 | 69 | 13 | 0.188 | 6 |
| ANGPTL8_ENST00000252453 | ANGPTL8 | Q6UXH0 | Angiopoietin-like protein 8 | chr19 | GO:0045444 | Not Cancer Driver | No | 17 | 0.086 | 26 | 6 | 0.231 | 0 |
| ARID5B | ARID5B | Q14865 | AT-rich interactive domain-containing protein 5B | chr10 | GO:0045444 | Not Cancer Driver | No | 162 | 0.136 | 769 | 95 | 0.124 | 0 |
| ARL4A_ENST00000356797 | ARL4A | P40617 | ADP-ribosylation factor-like protein 4A | chr7 | GO:0045444 | Not Cancer Driver | No | 32 | 0.16 | 13 | 2 | 0.154 | 0 |
| ATF2 | ATF2 | P15336 | Cyclic AMP-dependent transcription factor ATF-2 | chr2 | GO:0045444 | Not Cancer Driver | No | 65 | 0.129 | 451 | 58 | 0.129 | 0 |
| ATF5_ENST00000595125 | ATF5 | Q9Y2D1 | Cyclic AMP-dependent transcription factor ATF-5 | chr19 | GO:0045444 | Not Cancer Driver | No | 47 | 0.167 | 239 | 40 | 0.167 | 0 |
| BBS2 | BBS2 | Q9BXC9 | Bardet-Biedl syndrome 2 protein | chr16 | GO:0045444 | Not Cancer Driver | No | 90 | 0.125 | 76 | 16 | 0.211 | 20 |
| BBS4 | BBS4 | Q96RK4 | Bardet-Biedl syndrome 4 protein | chr15 | GO:0045444 | Not Cancer Driver | No | 58 | 0.112 | 110 | 16 | 0.145 | 9 |
| BBS7 | BBS7 | Q8IWZ6 | Bardet-Biedl syndrome 7 protein | chr4 | GO:0045444 | Not Cancer Driver | No | 99 | 0.138 | 56 | 8 | 0.143 | 4 |
| BBS9 | BBS9 | Q3SYG4 | Protein PTHB1 | chr7 | GO:0045444 | Not Cancer Driver | No | 152 | 0.171 | 103 | 23 | 0.223 | 1 |
| BSCL2_ENST00000421906 | BSCL2 | Q96G97 | Seipin | chr11 | GO:0045444 | Not Cancer Driver | No | 55 | 0.138 | 125 | 15 | 0.12 | 5 |
| C1QTNF3_ENST00000231338 | C1QTNF3 | Q9BXJ4 | Complement C1q tumor necrosis factor-related protein 3 | chr5 | GO:0045444 | Not Cancer Driver | No | 42 | 0.171 | 73 | 14 | 0.192 | 0 |
| CBY1_ENST00000216029 | CBY1 | Q9Y3M2 | Protein chibby homolog 1 | chr22 | GO:0045444 | Not Cancer Driver | No | 13 | 0.103 | 98 | 11 | 0.112 | 0 |
| CCND1 | CCND1 | P24385 | G1/S-specific cyclin-D1 | chr11 | GO:0045444 | Census, Compendium | Yes | 55 | 0.186 | 31 | 25 | 0.806 | 0 |
| CEBPA | CEBPA | P49715 | CCAAT/enhancer-binding protein alpha | chr19 | GO:0045444 | Census, Compendium | Yes | 12 | 0.034 | 342 | 12 | 0.035 | 1 |
| CEBPB | CEBPB | P17676 | CCAAT/enhancer-binding protein beta | chr20 | GO:0045444 | Not Cancer Driver | No | 3 | 0.009 | 276 | 2 | 0.007 | 0 |
| CEBPD | CEBPD | P49716 | CCAAT/enhancer-binding protein delta | chr8 | GO:0045444 | Not Cancer Driver | No | 5 | 0.019 | 234 | 4 | 0.017 | 0 |
| CLIP3_ENST00000593074 | CLIP3 | Q96DZ5 | CAP-Gly domain-containing linker protein 3 | chr19 | GO:0045444 | Not Cancer Driver | No | 78 | 0.143 | 218 | 22 | 0.101 | 0 |
| CNTN2 | CNTN2 | Q02246 | Contactin-2 | chr1 | GO:0045444 | Not Cancer Driver | No | 155 | 0.149 | 370 | 61 | 0.165 | 0 |
| CTBP1 | CTBP1 | Q13363 | C-terminal-binding protein 1 | chr4 | GO:0045444 | Not Cancer Driver | No | 42 | 0.095 | 123 | 9 | 0.073 | 1 |
| CTBP2_ENST00000494626 | CTBP2 | P56545 | C-terminal-binding protein 2 | chr10 | GO:0045444 | Not Cancer Driver | No | 48 | 0.108 | 94 | 4 | 0.043 | 0 |
| DHRS7B | DHRS7B | Q6IAN0 | Dehydrogenase/reductase SDR family member 7B | chr17 | GO:0045444 | Not Cancer Driver | No | 37 | 0.114 | 17 | 0 | 0.0 | 0 |
| DIO2_ENST00000557010 | DIO2 | Q92813 | Type II iodothyronine deiodinase | chr14 | GO:0045444 | Not Cancer Driver | No | 73 | 0.267 | 44 | 4 | 0.091 | 0 |
| EBF2 | EBF2 | Q9HAK2 | Transcription factor COE2 | chr8 | GO:0045444 | Not Cancer Driver | No | 158 | 0.275 | 261 | 71 | 0.272 | 0 |
| EGR2 | EGR2 | P11161 | E3 SUMO-protein ligase EGR2 | chr10 | GO:0045444 | Compendium | Yes | 90 | 0.189 | 352 | 59 | 0.168 | 11 |
| EP300 | EP300 | Q09472 | Histone acetyltransferase p300 | chr22 | GO:0045444 | Census, Compendium | Yes | 334 | 0.138 | 1790 | 196 | 0.109 | 1 |
| ERAP1_ENST00000443439 | ERAP1 | Q9NZ08 | Endoplasmic reticulum aminopeptidase 1 | chr5 | GO:0045444 | Not Cancer Driver | No | 78 | 0.083 | 70 | 2 | 0.029 | 0 |
| ERO1A | ERO1A | Q96HE7 | ERO1-like protein alpha | chr14 | GO:0045444 | Not Cancer Driver | No | 48 | 0.103 | 32 | 5 | 0.156 | 0 |
| FABP3 | FABP3 | P05413 | Fatty acid-binding protein, heart | chr1 | GO:0045444 | Not Cancer Driver | No | 22 | 0.165 | 3 | 0 | 0.0 | 0 |
| FABP4 | FABP4 | P15090 | Fatty acid-binding protein, adipocyte | chr8 | GO:0045444 | Not Cancer Driver | No | 14 | 0.106 | 4 | 0 | 0.0 | 0 |
| FAM120B_ENST00000476287 | FAM120B | Q96EK7 | Constitutive coactivator of peroxisome proliferator-activated receptor gamma | chr6 | GO:0045444 | Not Cancer Driver | No | 127 | 0.14 | 296 | 48 | 0.162 | 0 |
| FBXO9 | FBXO9 | Q9UK97 | F-box only protein 9 | chr6 | GO:0045444 | Not Cancer Driver | No | 49 | 0.11 | 110 | 7 | 0.064 | 0 |
| FFAR2 | FFAR2 | O15552 | Free fatty acid receptor 2 | chr19 | GO:0045444 | Not Cancer Driver | No | 49 | 0.148 | 32 | 7 | 0.219 | 0 |
| FFAR4_ENST00000371481 | FFAR4 | Q5NUL3 | Free fatty acid receptor 4 | chr10 | GO:0045444 | Not Cancer Driver | No | 47 | 0.13 | 0 | 0 | 0.0 | 0 |
| FGF10 | FGF10 | O15520 | Fibroblast growth factor 10 | chr5 | GO:0045444 | Not Cancer Driver | No | 56 | 0.269 | 34 | 11 | 0.324 | 2 |
| FOXO1 | FOXO1 | Q12778 | Forkhead box protein O1 | chr13 | GO:0045444 | Census, Compendium | Yes | 81 | 0.124 | 584 | 75 | 0.128 | 0 |
| GDF6 | GDF6 | Q6KF10 | Growth/differentiation factor 6 | chr8 | GO:0045444 | Not Cancer Driver | No | 91 | 0.2 | 225 | 46 | 0.204 | 14 |
| GPX1_ENST00000620890 | GPX1 | P07203 | Glutathione peroxidase 1 | chr3 | GO:0045444 | Not Cancer Driver | No | 38 | 0.187 | 12 | 1 | 0.083 | 0 |
| GRK5 | GRK5 | P34947 | G protein-coupled receptor kinase 5 | chr10 | GO:0045444 | Not Cancer Driver | No | 77 | 0.131 | 103 | 18 | 0.175 | 0 |
| HMGA2_ENST00000403681 | HMGA2 | P52926 | High mobility group protein HMGI-C | chr12 | GO:0045444 | Census | Yes | 12 | 0.11 | 109 | 12 | 0.11 | 0 |
| ID4 | ID4 | P47928 | DNA-binding protein inhibitor ID-4 | chr6 | GO:0045444 | Not Cancer Driver | No | 4 | 0.025 | 71 | 1 | 0.014 | 0 |
| IL11 | IL11 | P20809 | Interleukin-11 | chr19 | GO:0045444 | Not Cancer Driver | No | 19 | 0.095 | 69 | 8 | 0.116 | 0 |
| INHBB | INHBB | P09529 | Inhibin beta B chain | chr2 | GO:0045444 | Not Cancer Driver | No | 61 | 0.15 | 98 | 5 | 0.051 | 0 |
| LAMB3_ENST00000367030 | LAMB3 | Q13751 | Laminin subunit beta-3 | chr1 | GO:0045444 | Not Cancer Driver | No | 226 | 0.193 | 376 | 66 | 0.176 | 4 |
| LRG1 | LRG1 | P02750 | Leucine-rich alpha-2-glycoprotein | chr19 | GO:0045444 | Not Cancer Driver | No | 63 | 0.182 | 29 | 8 | 0.276 | 0 |
| LRRC8C | LRRC8C | Q8TDW0 | Volume-regulated anion channel subunit LRRC8C | chr1 | GO:0045444 | Not Cancer Driver | No | 93 | 0.116 | 59 | 6 | 0.102 | 0 |
| MAFB | MAFB | Q9Y5Q3 | Transcription factor MafB | chr20 | GO:0045444 | Census | Yes | 35 | 0.108 | 301 | 34 | 0.113 | 10 |
| MB_ENST00000397328 | MB | P02144 | Myoglobin | chr22 | GO:0045444 | Not Cancer Driver | No | 13 | 0.084 | 38 | 4 | 0.105 | 0 |
| MED1 | MED1 | Q15648 | Mediator of RNA polymerase II transcription subunit 1 | chr17 | GO:0045444 | Not Cancer Driver | No | 162 | 0.102 | 1104 | 117 | 0.106 | 0 |
| METRNL | METRNL | Q641Q3 | Meteorin-like protein | chr17 | GO:0045444 | Not Cancer Driver | No | 26 | 0.084 | 88 | 5 | 0.057 | 0 |
| MKKS | MKKS | Q9NPJ1 | McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin | chr20 | GO:0045444 | Not Cancer Driver | No | 56 | 0.098 | 6 | 1 | 0.167 | 22 |
| NIPBL | NIPBL | Q6KC79 | Nipped-B-like protein | chr5 | GO:0045444 | Compendium | Yes | 353 | 0.126 | 1528 | 184 | 0.12 | 37 |
| NOC3L | NOC3L | Q8WTT2 | Nucleolar complex protein 3 homolog | chr10 | GO:0045444 | Not Cancer Driver | No | 75 | 0.094 | 281 | 29 | 0.103 | 0 |
| NR4A1_ENST00000394825 | NR4A1 | P22736 | Nuclear receptor subfamily 4 group A member 1 | chr12 | GO:0045444 | Not Cancer Driver | No | 62 | 0.104 | 252 | 24 | 0.095 | 0 |
| NR4A2_ENST00000409572 | NR4A2 | P43354 | Nuclear receptor subfamily 4 group A member 2 | chr2 | GO:0045444 | Not Cancer Driver | No | 110 | 0.184 | 261 | 38 | 0.146 | 0 |
| NR4A3_ENST00000395097 | NR4A3 | Q92570 | Nuclear receptor subfamily 4 group A member 3 | chr9 | GO:0045444 | Census | Yes | 83 | 0.133 | 298 | 37 | 0.124 | 0 |
| NUDT7 | NUDT7 | P0C024 | Peroxisomal coenzyme A diphosphatase NUDT7 | chr16 | GO:0045444 | Not Cancer Driver | No | 45 | 0.189 | 42 | 4 | 0.095 | 0 |
| OSBPL11 | OSBPL11 | Q9BXB4 | Oxysterol-binding protein-related protein 11 | chr3 | GO:0045444 | Not Cancer Driver | No | 60 | 0.08 | 335 | 26 | 0.078 | 0 |
| OSBPL8 | OSBPL8 | Q9BZF1 | Oxysterol-binding protein-related protein 8 | chr12 | GO:0045444 | Not Cancer Driver | No | 105 | 0.118 | 401 | 37 | 0.092 | 0 |
| PDGFRA | PDGFRA | P16234 | Platelet-derived growth factor receptor alpha | chr4 | GO:0045444 | Census, Compendium | Yes | 290 | 0.266 | 173 | 45 | 0.26 | 2 |
| PER2 | PER2 | O15055 | Period circadian protein homolog 2 | chr2 | GO:0045444 | Not Cancer Driver | No | 166 | 0.132 | 782 | 101 | 0.129 | 1 |
| PEX11A | PEX11A | O75192 | Peroxisomal membrane protein 11A | chr15 | GO:0045444 | Not Cancer Driver | No | 33 | 0.134 | 0 | 0 | 0.0 | 0 |
| PIAS1_ENST00000249636 | PIAS1 | O75925 | E3 SUMO-protein ligase PIAS1 | chr15 | GO:0045444 | Not Cancer Driver | No | 80 | 0.123 | 241 | 43 | 0.178 | 0 |
| PID1 | PID1 | Q7Z2X4 | PTB-containing, cubilin and LRP1-interacting protein | chr2 | GO:0045444 | Not Cancer Driver | No | 70 | 0.28 | 24 | 10 | 0.417 | 0 |
| PLAC8_ENST00000505406 | PLAC8 | Q9NZF1 | Placenta-specific gene 8 protein | chr4 | GO:0045444 | Not Cancer Driver | No | 20 | 0.174 | 7 | 0 | 0.0 | 0 |
| PLCB1 | PLCB1 | Q9NQ66 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | chr20 | GO:0045444 | Not Cancer Driver | No | 313 | 0.257 | 481 | 104 | 0.216 | 0 |
| PNPLA3 | PNPLA3 | Q9NST1 | 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 | chr22 | GO:0045444 | Not Cancer Driver | No | 54 | 0.112 | 33 | 7 | 0.212 | 0 |
| PPARG | PPARG | P37231 | Peroxisome proliferator-activated receptor gamma | chr3 | GO:0045444 | Census | Yes | 72 | 0.143 | 44 | 4 | 0.091 | 3 |
| PPARGC1A | PPARGC1A | Q9UBK2 | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha | chr4 | GO:0045444 | Not Cancer Driver | No | 181 | 0.227 | 609 | 148 | 0.243 | 0 |
| PRDM16 | PRDM16 | Q9HAZ2 | Histone-lysine N-methyltransferase PRDM16 | chr1 | GO:0045444 | Census | Yes | 254 | 0.199 | 830 | 152 | 0.183 | 1 |
| PRLH | PRLH | P81277 | Prolactin-releasing peptide | chr2 | GO:0045444 | Not Cancer Driver | No | 10 | 0.115 | 28 | 3 | 0.107 | 0 |
| PSMB8 | PSMB8 | P28062 | Proteasome subunit beta type-8 | chr6 | GO:0045444 | Not Cancer Driver | No | 43 | 0.156 | 62 | 7 | 0.113 | 3 |
| PTGS2 | PTGS2 | P35354 | Prostaglandin G/H synthase 2 | chr1 | GO:0045444 | Not Cancer Driver | No | 105 | 0.174 | 30 | 5 | 0.167 | 0 |
| RETN | RETN | Q9HD89 | Resistin | chr19 | GO:0045444 | Not Cancer Driver | No | 10 | 0.093 | 0 | 0 | 0.0 | 0 |
| RETREG1 | RETREG1 | Q9H6L5 | Reticulophagy regulator 1 | chr5 | GO:0045444 | Not Cancer Driver | No | 48 | 0.097 | 245 | 21 | 0.086 | 0 |
| RGS2 | RGS2 | P41220 | Regulator of G-protein signaling 2 | chr1 | GO:0045444 | Not Cancer Driver | No | 30 | 0.142 | 50 | 4 | 0.08 | 0 |
| RNASEL | RNASEL | Q05823 | 2-5A-dependent ribonuclease | chr1 | GO:0045444 | Not Cancer Driver | No | 95 | 0.128 | 147 | 17 | 0.116 | 0 |
| SDF4 | SDF4 | Q9BRK5 | 45 kDa calcium-binding protein | chr1 | GO:0045444 | Not Cancer Driver | No | 48 | 0.133 | 187 | 30 | 0.16 | 0 |
| SENP2 | SENP2 | Q9HC62 | Sentrin-specific protease 2 | chr3 | GO:0045444 | Not Cancer Driver | No | 73 | 0.124 | 285 | 38 | 0.133 | 0 |
| SIRT1 | SIRT1 | Q96EB6 | NAD-dependent protein deacetylase sirtuin-1 | chr10 | GO:0045444 | Not Cancer Driver | No | 70 | 0.094 | 435 | 31 | 0.071 | 0 |
| SLC2A4 | SLC2A4 | P14672 | Solute carrier family 2, facilitated glucose transporter member 4 | chr17 | GO:0045444 | Not Cancer Driver | No | 71 | 0.139 | 43 | 8 | 0.186 | 1 |
| SMAD6 | SMAD6 | O43541 | Mothers against decapentaplegic homolog 6 | chr15 | GO:0045444 | Not Cancer Driver | No | 38 | 0.077 | 248 | 7 | 0.028 | 7 |
| SNAI2_ENST00000020945 | SNAI2 | O43623 | Zinc finger protein SNAI2 | chr8 | GO:0045444 | Not Cancer Driver | No | 52 | 0.194 | 52 | 9 | 0.173 | 0 |
| SOCS1 | SOCS1 | O15524 | Suppressor of cytokine signaling 1 | chr16 | GO:0045444 | Census, Compendium | Yes | 22 | 0.104 | 66 | 3 | 0.045 | 2 |
| SOX8 | SOX8 | P57073 | Transcription factor SOX-8 | chr16 | GO:0045444 | Not Cancer Driver | No | 43 | 0.096 | 403 | 39 | 0.097 | 0 |
| SREBF1_ENST00000261646 | SREBF1 | P36956 | Sterol regulatory element-binding protein 1 | chr17 | GO:0045444 | Not Cancer Driver | No | 127 | 0.111 | 528 | 64 | 0.121 | 4 |
| STEAP4 | STEAP4 | Q687X5 | Metalloreductase STEAP4 | chr7 | GO:0045444 | Not Cancer Driver | No | 97 | 0.211 | 0 | 0 | 0.0 | 0 |
| TBL1XR1 | TBL1XR1 | Q9BZK7 | F-box-like/WD repeat-containing protein TBL1XR1 | chr3 | GO:0045444 | Census, Compendium | Yes | 82 | 0.16 | 136 | 19 | 0.14 | 4 |
| TCF7L2_ENST00000355995 | TCF7L2 | Q9NQB0 | Transcription factor 7-like 2 | chr10 | GO:0045444 | Census, Compendium | Yes | 122 | 0.197 | 516 | 93 | 0.18 | 0 |
| TFAP2B | TFAP2B | Q92481 | Transcription factor AP-2-beta | chr6 | GO:0045444 | Not Cancer Driver | No | 114 | 0.248 | 306 | 75 | 0.245 | 6 |
| TMEM120A_ENST00000493111 | TMEM120A | Q9BXJ8 | Ion channel TACAN | chr7 | GO:0045444 | Not Cancer Driver | No | 30 | 0.087 | 26 | 0 | 0.0 | 0 |
| TMEM120B | TMEM120B | A0PK00 | Transmembrane protein 120B | chr12 | GO:0045444 | Not Cancer Driver | No | 37 | 0.109 | 6 | 1 | 0.167 | 0 |
| TRIM32 | TRIM32 | Q13049 | E3 ubiquitin-protein ligase TRIM32 | chr9 | GO:0045444 | Not Cancer Driver | No | 82 | 0.126 | 87 | 10 | 0.115 | 3 |
| TTC8_ENST00000338104 | TTC8 | Q8TAM2 | Tetratricopeptide repeat protein 8 | chr14 | GO:0045444 | Not Cancer Driver | No | 74 | 0.137 | 98 | 12 | 0.122 | 0 |
| UCP1 | UCP1 | P25874 | Mitochondrial brown fat uncoupling protein 1 | chr4 | GO:0045444 | Not Cancer Driver | No | 43 | 0.14 | 1 | 0 | 0.0 | 0 |
| WNT5B_ENST00000310594 | WNT5B | Q9H1J7 | Protein Wnt-5b | chr12 | GO:0045444 | Not Cancer Driver | No | 60 | 0.167 | 23 | 4 | 0.174 | 0 |
| ZBTB7A_ENST00000601588 | ZBTB7A | O95365 | Zinc finger and BTB domain-containing protein 7A | chr19 | GO:0045444 | Not Cancer Driver | No | 60 | 0.103 | 285 | 30 | 0.105 | 0 |
| ZNF516 | ZNF516 | Q92618 | Zinc finger protein 516 | chr18 | GO:0045444 | Not Cancer Driver | No | 177 | 0.152 | 861 | 131 | 0.152 | 0 |