Total number of protein in "GO:0045089" GO term: 97
| Identifier | UniProt Gene | UniProt Accession | UniProt Name | Chromosome | GO term | Database | Cancer Driver | Number of missense mutations | Missense mutation per residues | Number of disordered residues | Number of mutations in disordered regions | Disordered missense mutations per residues | Number of OMIM mutation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ADAM8 | ADAM8 | P78325 | Disintegrin and metalloproteinase domain-containing protein 8 | chr10 | GO:0045089 | Not Cancer Driver | No | 82 | 0.1 | 230 | 13 | 0.057 | 0 |
| AKIRIN2 | AKIRIN2 | Q53H80 | Akirin-2 | chr6 | GO:0045089 | Not Cancer Driver | No | 21 | 0.103 | 119 | 11 | 0.092 | 0 |
| AP1G1_ENST00000569748 | AP1G1 | O43747 | AP-1 complex subunit gamma-1 | chr16 | GO:0045089 | Not Cancer Driver | No | 111 | 0.135 | 144 | 22 | 0.153 | 0 |
| CADM1_ENST00000452722 | CADM1 | Q9BY67 | Cell adhesion molecule 1 | chr11 | GO:0045089 | Not Cancer Driver | No | 106 | 0.24 | 103 | 28 | 0.272 | 0 |
| CARD9 | CARD9 | Q9H257 | Caspase recruitment domain-containing protein 9 | chr9 | GO:0045089 | Not Cancer Driver | No | 72 | 0.134 | 225 | 35 | 0.156 | 11 |
| CD160_ENST00000369288 | CD160 | O95971 | CD160 antigen | chr1 | GO:0045089 | Not Cancer Driver | No | 20 | 0.11 | 2 | 0 | 0.0 | 0 |
| CD1D | CD1D | P15813 | Antigen-presenting glycoprotein CD1d | chr1 | GO:0045089 | Not Cancer Driver | No | 93 | 0.278 | 19 | 7 | 0.368 | 0 |
| CD226_ENST00000582621 | CD226 | Q15762 | CD226 antigen | chr18 | GO:0045089 | Not Cancer Driver | No | 79 | 0.235 | 47 | 11 | 0.234 | 0 |
| CLEC6A | CLEC6A | Q6EIG7 | C-type lectin domain family 6 member A | chr12 | GO:0045089 | Not Cancer Driver | No | 41 | 0.196 | 7 | 0 | 0.0 | 0 |
| CLEC7A | CLEC7A | Q9BXN2 | C-type lectin domain family 7 member A | chr12 | GO:0045089 | Not Cancer Driver | No | 43 | 0.174 | 46 | 2 | 0.043 | 0 |
| CLNK | CLNK | Q7Z7G1 | Cytokine-dependent hematopoietic cell linker | chr4 | GO:0045089 | Not Cancer Driver | No | 85 | 0.199 | 320 | 73 | 0.228 | 0 |
| COCH_ENST00000643575 | COCH | O43405 | Cochlin | chr14 | GO:0045089 | Not Cancer Driver | No | 81 | 0.147 | 43 | 6 | 0.14 | 14 |
| CREBBP | CREBBP | Q92793 | CREB-binding protein | chr16 | GO:0045089 | Census, Compendium | Yes | 412 | 0.169 | 1796 | 247 | 0.138 | 33 |
| CRTAM | CRTAM | O95727 | Cytotoxic and regulatory T-cell molecule | chr11 | GO:0045089 | Not Cancer Driver | No | 64 | 0.163 | 135 | 14 | 0.104 | 0 |
| CXorf21 | TASL | Q9HAI6 | TLR adapter interacting with SLC15A4 on the lysosome | chrX | GO:0045089 | Not Cancer Driver | No | 73 | 0.243 | 66 | 21 | 0.318 | 0 |
| DHX9 | DHX9 | Q08211 | ATP-dependent RNA helicase A | chr1 | GO:0045089 | Compendium | Yes | 182 | 0.143 | 331 | 42 | 0.127 | 0 |
| EP300 | EP300 | Q09472 | Histone acetyltransferase p300 | chr22 | GO:0045089 | Census, Compendium | Yes | 334 | 0.138 | 1790 | 196 | 0.109 | 1 |
| EREG | EREG | O14944 | Proepiregulin | chr4 | GO:0045089 | Not Cancer Driver | No | 26 | 0.154 | 10 | 3 | 0.3 | 0 |
| FADD | FADD | Q13158 | FAS-associated death domain protein | chr11 | GO:0045089 | Not Cancer Driver | No | 26 | 0.125 | 45 | 10 | 0.222 | 1 |
| FCN1 | FCN1 | O00602 | Ficolin-1 | chr9 | GO:0045089 | Not Cancer Driver | No | 107 | 0.328 | 88 | 15 | 0.17 | 0 |
| FFAR2 | FFAR2 | O15552 | Free fatty acid receptor 2 | chr19 | GO:0045089 | Not Cancer Driver | No | 49 | 0.148 | 32 | 7 | 0.219 | 0 |
| FPR2 | FPR2 | P25090 | N-formyl peptide receptor 2 | chr19 | GO:0045089 | Not Cancer Driver | No | 96 | 0.274 | 26 | 5 | 0.192 | 0 |
| FYN | FYN | P06241 | Tyrosine-protein kinase Fyn | chr6 | GO:0045089 | Not Cancer Driver | No | 92 | 0.171 | 70 | 13 | 0.186 | 0 |
| GBP5 | GBP5 | Q96PP8 | Guanylate-binding protein 5 | chr1 | GO:0045089 | Not Cancer Driver | No | 106 | 0.181 | 170 | 21 | 0.124 | 0 |
| HAVCR2 | HAVCR2 | Q8TDQ0 | Hepatitis A virus cellular receptor 2 | chr5 | GO:0045089 | Not Cancer Driver | No | 69 | 0.229 | 17 | 2 | 0.118 | 3 |
| HCK_ENST00000534862 | HCK | P08631 | Tyrosine-protein kinase HCK | chr20 | GO:0045089 | Not Cancer Driver | No | 112 | 0.213 | 124 | 25 | 0.202 | 0 |
| HLA-E | HLA-E | P13747 | HLA class I histocompatibility antigen, alpha chain E | chr6 | GO:0045089 | Not Cancer Driver | No | 63 | 0.176 | 138 | 39 | 0.283 | 0 |
| HLA-F_ENST00000376861 | HLA-F | P30511 | HLA class I histocompatibility antigen, alpha chain F | chr6 | GO:0045089 | Not Cancer Driver | No | 43 | 0.124 | 115 | 22 | 0.191 | 0 |
| HLA-G_ENST00000360323 | HLA-G | P17693 | HLA class I histocompatibility antigen, alpha chain G | chr6 | GO:0045089 | Not Cancer Driver | No | 94 | 0.278 | 85 | 22 | 0.259 | 0 |
| HMGB2 | HMGB2 | P26583 | High mobility group protein B2 | chr4 | GO:0045089 | Not Cancer Driver | No | 38 | 0.182 | 207 | 38 | 0.184 | 0 |
| HPX | HPX | P02790 | Hemopexin | chr11 | GO:0045089 | Not Cancer Driver | No | 60 | 0.13 | 53 | 8 | 0.151 | 0 |
| IFI35_ENST00000415816 | IFI35 | P80217 | Interferon-induced 35 kDa protein | chr17 | GO:0045089 | Not Cancer Driver | No | 33 | 0.115 | 63 | 10 | 0.159 | 0 |
| IFNB1 | IFNB1 | P01574 | Interferon beta | chr9 | GO:0045089 | Not Cancer Driver | No | 46 | 0.246 | 0 | 0 | 0.0 | 0 |
| IFNK | IFNK | Q9P0W0 | Interferon kappa | chr9 | GO:0045089 | Not Cancer Driver | No | 17 | 0.082 | 23 | 0 | 0.0 | 0 |
| IKBKB | IKBKB | O14920 | Inhibitor of nuclear factor kappa-B kinase subunit beta | chr8 | GO:0045089 | Census, Compendium | Yes | 106 | 0.14 | 211 | 31 | 0.147 | 1 |
| IKBKE | IKBKE | Q14164 | Inhibitor of nuclear factor kappa-B kinase subunit epsilon | chr1 | GO:0045089 | Not Cancer Driver | No | 108 | 0.151 | 76 | 13 | 0.171 | 0 |
| IL12B | IL12B | P29460 | Interleukin-12 subunit beta | chr5 | GO:0045089 | Not Cancer Driver | No | 48 | 0.146 | 42 | 2 | 0.048 | 0 |
| IRF3_ENST00000597198 | IRF3 | Q14653 | Interferon regulatory factor 3 | chr19 | GO:0045089 | Not Cancer Driver | No | 36 | 0.084 | 204 | 21 | 0.103 | 1 |
| IRF7_ENST00000397574 | IRF7 | Q92985 | Interferon regulatory factor 7 | chr11 | GO:0045089 | Not Cancer Driver | No | 43 | 0.085 | 253 | 19 | 0.075 | 1 |
| IRGM | IRGM | A1A4Y4 | Immunity-related GTPase family M protein | chr5 | GO:0045089 | Not Cancer Driver | No | 9 | 0.05 | 45 | 1 | 0.022 | 0 |
| KLRC2 | KLRC2 | P26717 | NKG2-C type II integral membrane protein | chr12 | GO:0045089 | Not Cancer Driver | No | 55 | 0.238 | 45 | 17 | 0.378 | 0 |
| KLRC3_ENST00000396439 | KLRC3 | Q07444 | NKG2-E type II integral membrane protein | chr12 | GO:0045089 | Not Cancer Driver | No | 37 | 0.154 | 43 | 4 | 0.093 | 0 |
| KLRC4 | KLRC4 | O43908 | NKG2-F type II integral membrane protein | chr12 | GO:0045089 | Not Cancer Driver | No | 36 | 0.228 | 45 | 7 | 0.156 | 0 |
| KLRD1 | KLRD1 | Q13241 | Natural killer cells antigen CD94 | chr12 | GO:0045089 | Not Cancer Driver | No | 37 | 0.207 | 0 | 0 | 0.0 | 0 |
| KLRK1 | KLRK1 | P26718 | NKG2-D type II integral membrane protein | chr12 | GO:0045089 | Not Cancer Driver | No | 38 | 0.176 | 0 | 0 | 0.0 | 0 |
| LAMP1 | LAMP1 | P11279 | Lysosome-associated membrane glycoprotein 1 | chr13 | GO:0045089 | Not Cancer Driver | No | 47 | 0.113 | 93 | 10 | 0.108 | 0 |
| LBP | LBP | P18428 | Lipopolysaccharide-binding protein | chr20 | GO:0045089 | Not Cancer Driver | No | 84 | 0.175 | 6 | 0 | 0.0 | 0 |
| LILRA2 | LILRA2 | Q8N149 | Leukocyte immunoglobulin-like receptor subfamily A member 2 | chr19 | GO:0045089 | Not Cancer Driver | No | 163 | 0.337 | 137 | 44 | 0.321 | 0 |
| LSM14A_ENST00000433627 | LSM14A | Q8ND56 | Protein LSM14 homolog A | chr19 | GO:0045089 | Census | Yes | 67 | 0.145 | 408 | 63 | 0.154 | 0 |
| LYN | LYN | P07948 | Tyrosine-protein kinase Lyn | chr8 | GO:0045089 | Census | Yes | 95 | 0.186 | 84 | 12 | 0.143 | 0 |
| MAP3K7 | MAP3K7 | O43318 | Mitogen-activated protein kinase kinase kinase 7 | chr6 | GO:0045089 | Not Cancer Driver | No | 104 | 0.172 | 333 | 66 | 0.198 | 6 |
| MAVS | MAVS | Q7Z434 | Mitochondrial antiviral-signaling protein | chr20 | GO:0045089 | Not Cancer Driver | No | 70 | 0.13 | 411 | 58 | 0.141 | 0 |
| MBL2 | MBL2 | P11226 | Mannose-binding protein C | chr10 | GO:0045089 | Not Cancer Driver | No | 63 | 0.254 | 122 | 32 | 0.262 | 0 |
| MED1 | MED1 | Q15648 | Mediator of RNA polymerase II transcription subunit 1 | chr17 | GO:0045089 | Not Cancer Driver | No | 162 | 0.102 | 1104 | 117 | 0.106 | 0 |
| MMP12 | MMP12 | P39900 | Macrophage metalloelastase | chr11 | GO:0045089 | Not Cancer Driver | No | 100 | 0.213 | 29 | 5 | 0.172 | 0 |
| NECTIN2 | NECTIN2 | Q92692 | Nectin-2 | chr19 | GO:0045089 | Not Cancer Driver | No | 63 | 0.117 | 296 | 29 | 0.098 | 0 |
| NLRC5_ENST00000436936 | NLRC5 | Q86WI3 | Protein NLRC5 | chr16 | GO:0045089 | Not Cancer Driver | No | 262 | 0.14 | 114 | 19 | 0.167 | 0 |
| NMI | NMI | Q13287 | N-myc-interactor | chr2 | GO:0045089 | Not Cancer Driver | No | 34 | 0.111 | 104 | 12 | 0.115 | 0 |
| NOD2 | NOD2 | Q9HC29 | Nucleotide-binding oligomerization domain-containing protein 2 | chr16 | GO:0045089 | Not Cancer Driver | No | 169 | 0.163 | 40 | 4 | 0.1 | 15 |
| PAK1_ENST00000356341 | PAK1 | Q13153 | Serine/threonine-protein kinase PAK 1 | chr11 | GO:0045089 | Not Cancer Driver | No | 57 | 0.105 | 299 | 30 | 0.1 | 2 |
| PAK2 | PAK2 | Q13177 | Serine/threonine-protein kinase PAK 2 | chr3 | GO:0045089 | Compendium | Yes | 89 | 0.17 | 242 | 49 | 0.202 | 0 |
| PAK3_ENST00000262836 | PAK3 | O75914 | Serine/threonine-protein kinase PAK 3 | chrX | GO:0045089 | Not Cancer Driver | No | 127 | 0.227 | 286 | 64 | 0.224 | 2 |
| PARP9 | PARP9 | Q8IXQ6 | Protein mono-ADP-ribosyltransferase PARP9 | chr3 | GO:0045089 | Not Cancer Driver | No | 110 | 0.129 | 45 | 3 | 0.067 | 0 |
| PLA2G5 | PLA2G5 | P39877 | Phospholipase A2 group V | chr1 | GO:0045089 | Not Cancer Driver | No | 24 | 0.174 | 0 | 0 | 0.0 | 2 |
| PLCG2 | PLCG2 | P16885 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 | chr16 | GO:0045089 | Not Cancer Driver | No | 248 | 0.196 | 142 | 30 | 0.211 | 1 |
| PLSCR1 | PLSCR1 | O15162 | Phospholipid scramblase 1 | chr3 | GO:0045089 | Not Cancer Driver | No | 43 | 0.135 | 92 | 13 | 0.141 | 0 |
| POLR3B | POLR3B | Q9NW08 | DNA-directed RNA polymerase III subunit RPC2 | chr12 | GO:0045089 | Not Cancer Driver | No | 164 | 0.145 | 117 | 20 | 0.171 | 8 |
| POLR3C | POLR3C | Q9BUI4 | DNA-directed RNA polymerase III subunit RPC3 | chr1 | GO:0045089 | Not Cancer Driver | No | 60 | 0.112 | 161 | 21 | 0.13 | 0 |
| POLR3D | POLR3D | P05423 | DNA-directed RNA polymerase III subunit RPC4 | chr8 | GO:0045089 | Not Cancer Driver | No | 33 | 0.083 | 303 | 24 | 0.079 | 0 |
| POLR3F | POLR3F | Q9H1D9 | DNA-directed RNA polymerase III subunit RPC6 | chr20 | GO:0045089 | Not Cancer Driver | No | 20 | 0.063 | 55 | 5 | 0.091 | 0 |
| POLR3G | POLR3G | O15318 | DNA-directed RNA polymerase III subunit RPC7 | chr5 | GO:0045089 | Not Cancer Driver | No | 28 | 0.126 | 187 | 15 | 0.08 | 0 |
| PVR | PVR | P15151 | Poliovirus receptor | chr19 | GO:0045089 | Not Cancer Driver | No | 39 | 0.094 | 120 | 19 | 0.158 | 0 |
| RAET1G | RAET1G | Q6H3X3 | UL-16 binding protein 5 | chr6 | GO:0045089 | Not Cancer Driver | No | 41 | 0.123 | 62 | 10 | 0.161 | 0 |
| RIOK3 | RIOK3 | O14730 | Serine/threonine-protein kinase RIO3 | chr18 | GO:0045089 | Not Cancer Driver | No | 58 | 0.112 | 225 | 21 | 0.093 | 0 |
| RNF185 | RNF185 | Q96GF1 | E3 ubiquitin-protein ligase RNF185 | chr22 | GO:0045089 | Not Cancer Driver | No | 25 | 0.13 | 82 | 15 | 0.183 | 0 |
| RPS19_ENST00000600467 | RPS19 | P39019 | 40S ribosomal protein S19 | chr19 | GO:0045089 | Not Cancer Driver | No | 15 | 0.103 | 61 | 3 | 0.049 | 23 |
| SH2D1B | SH2D1B | O14796 | SH2 domain-containing protein 1B | chr1 | GO:0045089 | Not Cancer Driver | No | 34 | 0.258 | 0 | 0 | 0.0 | 0 |
| SLC15A4 | SLC15A4 | Q8N697 | Solute carrier family 15 member 4 | chr12 | GO:0045089 | Not Cancer Driver | No | 66 | 0.114 | 23 | 4 | 0.174 | 0 |
| SPI1_ENST00000378538 | SPI1 | P17947 | Transcription factor PU.1 | chr11 | GO:0045089 | Not Cancer Driver | No | 46 | 0.17 | 187 | 34 | 0.182 | 0 |
| SRC_ENST00000358208 | SRC | P12931 | Proto-oncogene tyrosine-protein kinase Src | chr20 | GO:0045089 | Census | Yes | 53 | 0.099 | 130 | 11 | 0.085 | 1 |
| SYK_ENST00000375746 | SYK | P43405 | Tyrosine-protein kinase SYK | chr9 | GO:0045089 | Census | Yes | 96 | 0.151 | 131 | 27 | 0.206 | 5 |
| TBK1 | TBK1 | Q9UHD2 | Serine/threonine-protein kinase TBK1 | chr12 | GO:0045089 | Not Cancer Driver | No | 101 | 0.139 | 42 | 5 | 0.119 | 12 |
| TIRAP_ENST00000392680 | TIRAP | P58753 | Toll/interleukin-1 receptor domain-containing adapter protein | chr11 | GO:0045089 | Not Cancer Driver | No | 28 | 0.127 | 80 | 6 | 0.075 | 0 |
| TLR8_ENST00000218032 | TLR8 | Q9NR97 | Toll-like receptor 8 | chrX | GO:0045089 | Not Cancer Driver | No | 180 | 0.173 | 30 | 7 | 0.233 | 0 |
| TMEM173 | STING1 | Q86WV6 | Stimulator of interferon genes protein | chr5 | GO:0045089 | Not Cancer Driver | No | 46 | 0.121 | 66 | 13 | 0.197 | 3 |
| TRAF6_ENST00000348124 | TRAF6 | Q9Y4K3 | TNF receptor-associated factor 6 | chr11 | GO:0045089 | Not Cancer Driver | No | 67 | 0.128 | 62 | 7 | 0.113 | 0 |
| TRIM41 | TRIM41 | Q8WV44 | E3 ubiquitin-protein ligase TRIM41 | chr5 | GO:0045089 | Not Cancer Driver | No | 69 | 0.11 | 385 | 38 | 0.099 | 0 |
| TRIM56 | TRIM56 | Q9BRZ2 | E3 ubiquitin-protein ligase TRIM56 | chr7 | GO:0045089 | Not Cancer Driver | No | 110 | 0.146 | 217 | 36 | 0.166 | 0 |
| TRIM62 | TRIM62 | Q9BVG3 | E3 ubiquitin-protein ligase TRIM62 | chr1 | GO:0045089 | Not Cancer Driver | No | 58 | 0.122 | 80 | 14 | 0.175 | 0 |
| TRIM6_ENST00000278302 | TRIM6 | Q9C030 | Tripartite motif-containing protein 6 | chr11 | GO:0045089 | Not Cancer Driver | No | 86 | 0.176 | 47 | 15 | 0.319 | 0 |
| TXK | TXK | P42681 | Tyrosine-protein kinase TXK | chr4 | GO:0045089 | Not Cancer Driver | No | 87 | 0.165 | 61 | 9 | 0.148 | 0 |
| TYROBP | TYROBP | O43914 | TYRO protein tyrosine kinase-binding protein | chr19 | GO:0045089 | Not Cancer Driver | No | 24 | 0.212 | 28 | 8 | 0.286 | 0 |
| UBE2K | UBE2K | P61086 | Ubiquitin-conjugating enzyme E2 K | chr4 | GO:0045089 | Not Cancer Driver | No | 24 | 0.12 | 33 | 3 | 0.091 | 0 |
| USP27X | USP27X | A6NNY8 | Ubiquitin carboxyl-terminal hydrolase 27 | chrX | GO:0045089 | Not Cancer Driver | No | 31 | 0.071 | 69 | 3 | 0.043 | 1 |
| USP29_ENST00000598197 | USP29 | Q9HBJ7 | Ubiquitin carboxyl-terminal hydrolase 29 | chr19 | GO:0045089 | Not Cancer Driver | No | 291 | 0.316 | 432 | 132 | 0.306 | 0 |
| WNT5A_ENST00000474267 | WNT5A | P41221 | Protein Wnt-5a | chr3 | GO:0045089 | Not Cancer Driver | No | 66 | 0.174 | 0 | 0 | 0.0 | 2 |
| ZBP1 | ZBP1 | Q9H171 | Z-DNA-binding protein 1 | chr20 | GO:0045089 | Not Cancer Driver | No | 97 | 0.226 | 385 | 80 | 0.208 | 0 |