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Total number of protein in "GO:0043549" GO term:  391

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
ABI1 ABI1 Q8IZP0 Abl interactor 1 chr10 GO:0043549 Census, Compendium Yes 55 0.108 360 39 0.108 0
ABL1_ENST00000318560 ABL1 P00519 Tyrosine-protein kinase ABL1 chr9 GO:0043549 Census, Compendium Yes 139 0.123 604 73 0.121 2
ACE ACE P12821 Angiotensin-converting enzyme chr17 GO:0043549 Not Cancer Driver No 201 0.154 86 8 0.093 0
ADAM17 ADAM17 P78536 Disintegrin and metalloproteinase domain-containing protein 17 chr2 GO:0043549 Not Cancer Driver No 80 0.097 182 17 0.093 0
ADAR ADAR P55265 Double-stranded RNA-specific adenosine deaminase chr1 GO:0043549 Not Cancer Driver No 149 0.122 675 83 0.123 12
ADARB1 ADARB1 P78563 Double-stranded RNA-specific editase 1 chr21 GO:0043549 Not Cancer Driver No 102 0.138 348 34 0.098 1
ADCY8 ADCY8 P40145 Adenylate cyclase type 8 chr8 GO:0043549 Not Cancer Driver No 419 0.335 215 38 0.177 0
ADIPOQ ADIPOQ Q15848 Adiponectin chr3 GO:0043549 Not Cancer Driver No 39 0.16 92 21 0.228 1
ADORA1 ADORA1 P30542 Adenosine receptor A1 chr1 GO:0043549 Not Cancer Driver No 64 0.196 12 4 0.333 0
ADRA1A_ENST00000380573 ADRA1A P35348 Alpha-1A adrenergic receptor chr8 GO:0043549 Not Cancer Driver No 130 0.279 40 8 0.2 0
ADRA2A ADRA2A P08913 Alpha-2A adrenergic receptor chr10 GO:0043549 Not Cancer Driver No 67 0.144 161 10 0.062 0
ADRA2B ADRA2B P18089 Alpha-2B adrenergic receptor chr2 GO:0043549 Not Cancer Driver No 73 0.162 136 20 0.147 0
ADRA2C ADRA2C P18825 Alpha-2C adrenergic receptor chr4 GO:0043549 Not Cancer Driver No 47 0.102 107 0 0.0 0
ADRB2 ADRB2 P07550 Beta-2 adrenergic receptor chr5 GO:0043549 Not Cancer Driver No 52 0.126 35 4 0.114 0
AFAP1L2 AFAP1L2 Q8N4X5 Actin filament-associated protein 1-like 2 chr10 GO:0043549 Not Cancer Driver No 86 0.105 558 59 0.106 0
AGAP2 AGAP2 Q99490 Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 chr12 GO:0043549 Not Cancer Driver No 133 0.112 754 81 0.107 0
AGER_ENST00000375076 AGER Q15109 Advanced glycosylation end product-specific receptor chr6 GO:0043549 Not Cancer Driver No 31 0.077 297 21 0.071 0
AGT AGT P01019 Angiotensinogen chr1 GO:0043549 Not Cancer Driver No 85 0.179 33 10 0.303 1
AIDA AIDA Q96BJ3 Axin interactor, dorsalization-associated protein chr1 GO:0043549 Not Cancer Driver No 36 0.118 87 9 0.103 0
AKT1_ENST00000349310 AKT1 P31749 RAC-alpha serine/threonine-protein kinase chr14 GO:0043549 Census, Compendium Yes 108 0.225 158 24 0.152 4
ALKAL1 ALKAL1 Q6UXT8 ALK and LTK ligand 1 chr8 GO:0043549 Not Cancer Driver No 18 0.14 49 3 0.061 0
ALKAL2 ALKAL2 Q6UX46 ALK and LTK ligand 2 chr2 GO:0043549 Not Cancer Driver No 7 0.046 31 0 0.0 0
AMBRA1_ENST00000458649 AMBRA1 Q9C0C7 Activating molecule in BECN1-regulated autophagy protein 1 chr11 GO:0043549 Not Cancer Driver No 173 0.133 788 103 0.131 0
ANG ANG P03950 Angiogenin chr14 GO:0043549 Not Cancer Driver No 19 0.129 36 2 0.056 14
ANGPT1 ANGPT1 Q15389 Angiopoietin-1 chr8 GO:0043549 Not Cancer Driver No 130 0.261 131 24 0.183 1
ANGPT4 ANGPT4 Q9Y264 Angiopoietin-4 chr20 GO:0043549 Not Cancer Driver No 104 0.207 150 32 0.213 0
APC APC P25054 Adenomatous polyposis coli protein chr5 GO:0043549 Census, Compendium Yes 412 0.145 2406 345 0.143 22
APP APP P05067 Amyloid-beta precursor protein chr21 GO:0043549 Not Cancer Driver No 128 0.166 418 71 0.17 17
AREG AREG P15514 Amphiregulin chr4 GO:0043549 Not Cancer Driver No 28 0.111 149 20 0.134 0
ARHGEF5 ARHGEF5 Q12774 Rho guanine nucleotide exchange factor 5 chr7 GO:0043549 Not Cancer Driver No 170 0.106 1141 127 0.111 0
ATG14 ATG14 Q6ZNE5 Beclin 1-associated autophagy-related key regulator chr14 GO:0043549 Not Cancer Driver No 48 0.098 209 24 0.115 0
AXIN1 AXIN1 O15169 Axin-1 chr16 GO:0043549 Census, Compendium Yes 120 0.139 619 88 0.142 4
BAD_ENST00000309032 BAD Q92934 Bcl2-associated agonist of cell death chr11 GO:0043549 Not Cancer Driver No 14 0.083 163 14 0.086 0
BTC BTC P35070 Probetacellulin chr4 GO:0043549 Not Cancer Driver No 29 0.163 12 5 0.417 0
C5AR1 C5AR1 P21730 C5a anaphylatoxin chemotactic receptor 1 chr19 GO:0043549 Not Cancer Driver No 71 0.203 0 0 0.0 0
CARD10_ENST00000251973 CARD10 Q9BWT7 Caspase recruitment domain-containing protein 10 chr22 GO:0043549 Not Cancer Driver No 94 0.091 474 40 0.084 0
CARD14 CARD14 Q9BXL6 Caspase recruitment domain-containing protein 14 chr17 GO:0043549 Not Cancer Driver No 99 0.099 296 36 0.122 11
CASP3 CASP3 P42574 Caspase-3 chr4 GO:0043549 Census Yes 32 0.116 62 5 0.081 0
CASS4 CASS4 Q9NQ75 Cas scaffolding protein family member 4 chr20 GO:0043549 Not Cancer Driver No 204 0.26 496 137 0.276 0
CAV1 CAV1 Q03135 Caveolin-1 chr7 GO:0043549 Not Cancer Driver No 30 0.169 2 0 0.0 0
CBL CBL P22681 E3 ubiquitin-protein ligase CBL chr11 GO:0043549 Census, Compendium Yes 115 0.127 512 56 0.109 4
CBLB CBLB Q13191 E3 ubiquitin-protein ligase CBL-B chr3 GO:0043549 Census Yes 160 0.163 562 104 0.185 0
CBLC_ENST00000647358 CBLC Q9ULV8 E3 ubiquitin-protein ligase CBL-C chr19 GO:0043549 Census Yes 60 0.127 128 21 0.164 0
CCDC88A_ENST00000642200 CCDC88A Q3V6T2 Girdin chr2 GO:0043549 Not Cancer Driver No 226 0.121 1481 173 0.117 0
CCKBR CCKBR P32239 Gastrin/cholecystokinin type B receptor chr11 GO:0043549 Not Cancer Driver No 122 0.273 61 22 0.361 0
CCL19 CCL19 Q99731 C-C motif chemokine 19 chr9 GO:0043549 Not Cancer Driver No 10 0.102 7 0 0.0 0
CCL21 CCL21 O00585 C-C motif chemokine 21 chr9 GO:0043549 Not Cancer Driver No 14 0.104 59 6 0.102 0
CCNB1 CCNB1 P14635 G2/mitotic-specific cyclin-B1 chr5 GO:0043549 Not Cancer Driver No 49 0.113 145 14 0.097 0
CCND1 CCND1 P24385 G1/S-specific cyclin-D1 chr11 GO:0043549 Census, Compendium Yes 55 0.186 31 25 0.806 0
CCND2 CCND2 P30279 G1/S-specific cyclin-D2 chr12 GO:0043549 Census, Compendium Yes 39 0.135 29 7 0.241 5
CCND3 CCND3 P30281 G1/S-specific cyclin-D3 chr6 GO:0043549 Census, Compendium Yes 29 0.099 46 8 0.174 0
CCNK CCNK O75909 Cyclin-K chr14 GO:0043549 Not Cancer Driver No 39 0.067 347 15 0.043 1
CCNT1 CCNT1 O60563 Cyclin-T1 chr12 GO:0043549 Not Cancer Driver No 85 0.117 495 61 0.123 0
CCNT2 CCNT2 O60583 Cyclin-T2 chr2 GO:0043549 Not Cancer Driver No 76 0.104 471 52 0.11 0
CCNY CCNY Q8ND76 Cyclin-Y chr10 GO:0043549 Not Cancer Driver No 38 0.111 94 6 0.064 0
CCNYL1 CCNYL1 Q8N7R7 Cyclin-Y-like protein 1 chr2 GO:0043549 Not Cancer Driver No 31 0.086 100 8 0.08 0
CCR7 CCR7 P32248 C-C chemokine receptor type 7 chr17 GO:0043549 Census, Compendium Yes 50 0.132 0 0 0.0 0
CD19_ENST00000324662 CD19 P15391 B-lymphocyte antigen CD19 chr16 GO:0043549 Not Cancer Driver No 80 0.144 312 46 0.147 0
CD300A CD300A Q9UGN4 CMRF35-like molecule 8 chr17 GO:0043549 Not Cancer Driver No 53 0.177 70 10 0.143 0
CD81 CD81 P60033 CD81 antigen chr11 GO:0043549 Not Cancer Driver No 28 0.119 0 0 0.0 0
CD86 CD86 P42081 T-lymphocyte activation antigen CD86 chr3 GO:0043549 Not Cancer Driver No 90 0.274 56 18 0.321 0
CDC42_ENST00000344548 CDC42 P60953 Cell division control protein 42 homolog chr1 GO:0043549 Not Cancer Driver No 39 0.204 23 2 0.087 1
CDC6 CDC6 Q99741 Cell division control protein 6 homolog chr17 GO:0043549 Not Cancer Driver No 57 0.102 170 15 0.088 1
CDK5R1 CDK5R1 Q15078 Cyclin-dependent kinase 5 activator 1 chr17 GO:0043549 Not Cancer Driver No 35 0.114 103 16 0.155 0
CDK5R2 CDK5R2 Q13319 Cyclin-dependent kinase 5 activator 2 chr2 GO:0043549 Not Cancer Driver No 14 0.038 204 5 0.025 0
CDK5RAP1_ENST00000357886 CDK5RAP1 Q96SZ6 Mitochondrial tRNA methylthiotransferase CDK5RAP1 chr20 GO:0043549 Not Cancer Driver No 73 0.121 95 12 0.126 0
CDK5RAP2 CDK5RAP2 Q96SN8 CDK5 regulatory subunit-associated protein 2 chr9 GO:0043549 Not Cancer Driver No 217 0.115 1136 128 0.113 0
CDK5RAP3_ENST00000338399 CDK5RAP3 Q96JB5 CDK5 regulatory subunit-associated protein 3 chr17 GO:0043549 Not Cancer Driver No 50 0.099 99 20 0.202 0
CDKN1A_ENST00000373711 CDKN1A P38936 Cyclin-dependent kinase inhibitor 1 chr6 GO:0043549 Census, Compendium Yes 48 0.293 121 30 0.248 0
CDKN1B CDKN1B P46527 Cyclin-dependent kinase inhibitor 1B chr12 GO:0043549 Census, Compendium Yes 19 0.096 198 19 0.096 0
CDKN1C CDKN1C P49918 Cyclin-dependent kinase inhibitor 1C chr11 GO:0043549 Not Cancer Driver No 2 0.006 256 1 0.004 7
CDKN2A_ENST00000304494 CDKN2A P42771 Cyclin-dependent kinase inhibitor 2A chr9 GO:0043549 Census, Compendium Yes 166 1.064 83 88 1.06 36
CDKN2B CDKN2B P42772 Cyclin-dependent kinase 4 inhibitor B chr9 GO:0043549 Not Cancer Driver No 15 0.109 67 3 0.045 0
CDKN2C_ENST00000371761 CDKN2C P42773 Cyclin-dependent kinase 4 inhibitor C chr1 GO:0043549 Census, Compendium Yes 23 0.137 49 6 0.122 0
CDKN2D_ENST00000335766 CDKN2D P55273 Cyclin-dependent kinase 4 inhibitor D chr19 GO:0043549 Not Cancer Driver No 17 0.102 44 3 0.068 0
CEBPA CEBPA P49715 CCAAT/enhancer-binding protein alpha chr19 GO:0043549 Census, Compendium Yes 12 0.034 342 12 0.035 1
CEMIP_ENST00000356249 CEMIP Q8WUJ3 Cell migration-inducing and hyaluronan-binding protein chr15 GO:0043549 Not Cancer Driver No 207 0.152 105 10 0.095 0
CHI3L1 CHI3L1 P36222 Chitinase-3-like protein 1 chr1 GO:0043549 Not Cancer Driver No 66 0.172 24 5 0.208 0
CHMP6 CHMP6 Q96FZ7 Charged multivesicular body protein 6 chr17 GO:0043549 Not Cancer Driver No 26 0.129 88 16 0.182 0
CHORDC1 CHORDC1 Q9UHD1 Cysteine and histidine-rich domain-containing protein 1 chr11 GO:0043549 Not Cancer Driver No 47 0.142 119 17 0.143 0
CHRNA3 CHRNA3 P32297 Neuronal acetylcholine receptor subunit alpha-3 chr15 GO:0043549 Not Cancer Driver No 86 0.17 11 1 0.091 0
CISH_ENST00000348721 CISH Q9NSE2 Cytokine-inducible SH2-containing protein chr3 GO:0043549 Not Cancer Driver No 33 0.128 97 8 0.082 0
CKS1B CKS1B P61024 Cyclin-dependent kinases regulatory subunit 1 chr1 GO:0043549 Not Cancer Driver No 10 0.127 10 0 0.0 0
CKS2 CKS2 P33552 Cyclin-dependent kinases regulatory subunit 2 chr9 GO:0043549 Not Cancer Driver No 9 0.114 10 2 0.2 0
CLU_ENST00000523500 CLU P10909 Clusterin chr8 GO:0043549 Not Cancer Driver No 69 0.154 156 27 0.173 0
COPS8 COPS8 Q99627 COP9 signalosome complex subunit 8 chr2 GO:0043549 Not Cancer Driver No 25 0.12 14 2 0.143 0
CORO1C_ENST00000541050 CORO1C Q9ULV4 Coronin-1C chr12 GO:0043549 Not Cancer Driver No 61 0.129 84 13 0.155 0
COX11 COX11 Q9Y6N1 Cytochrome c oxidase assembly protein COX11, mitochondrial chr17 GO:0043549 Not Cancer Driver No 21 0.076 51 4 0.078 0
CSF1R CSF1R P07333 Macrophage colony-stimulating factor 1 receptor chr5 GO:0043549 Census Yes 133 0.137 124 17 0.137 20
DAB2 DAB2 P98082 Disabled homolog 2 chr5 GO:0043549 Not Cancer Driver No 144 0.187 680 125 0.184 0
DAB2IP_ENST00000408936 DAB2IP Q5VWQ8 Disabled homolog 2-interacting protein chr9 GO:0043549 Not Cancer Driver No 131 0.11 681 68 0.1 0
DGKQ DGKQ P52824 Diacylglycerol kinase theta chr4 GO:0043549 Not Cancer Driver No 56 0.059 264 11 0.042 0
DGKZ_ENST00000456247 DGKZ Q13574 Diacylglycerol kinase zeta chr11 GO:0043549 Not Cancer Driver No 87 0.094 410 42 0.102 0
DIPK2A DIPK2A Q8NDZ4 Divergent protein kinase domain 2A chr3 GO:0043549 Not Cancer Driver No 56 0.13 9 0 0.0 0
DKK1 DKK1 O94907 Dickkopf-related protein 1 chr10 GO:0043549 Not Cancer Driver No 58 0.218 47 8 0.17 0
DLG3 DLG3 Q92796 Disks large homolog 3 chrX GO:0043549 Not Cancer Driver No 94 0.115 322 30 0.093 0
DLG4_ENST00000399506 DLG4 P78352 Disks large homolog 4 chr17 GO:0043549 Not Cancer Driver No 116 0.16 232 55 0.237 0
DNAJA1 DNAJA1 P31689 DnaJ homolog subfamily A member 1 chr9 GO:0043549 Not Cancer Driver No 37 0.093 153 16 0.105 0
DOCK3 DOCK3 Q8IZD9 Dedicator of cytokinesis protein 3 chr3 GO:0043549 Not Cancer Driver No 365 0.18 458 69 0.151 0
DOK7 DOK7 Q18PE1 Protein Dok-7 chr4 GO:0043549 Not Cancer Driver No 52 0.103 286 27 0.094 19
DTNBP1 DTNBP1 Q96EV8 Dysbindin chr6 GO:0043549 Not Cancer Driver No 49 0.14 210 25 0.119 0
DUSP10 DUSP10 Q9Y6W6 Dual specificity protein phosphatase 10 chr1 GO:0043549 Not Cancer Driver No 81 0.168 135 24 0.178 0
DUSP12 DUSP12 Q9UNI6 Dual specificity protein phosphatase 12 chr1 GO:0043549 Not Cancer Driver No 33 0.097 30 1 0.033 0
DUSP16 DUSP16 Q9BY84 Dual specificity protein phosphatase 16 chr12 GO:0043549 Compendium Yes 70 0.105 273 34 0.125 0
DUSP19 DUSP19 Q8WTR2 Dual specificity protein phosphatase 19 chr2 GO:0043549 Not Cancer Driver No 34 0.157 15 5 0.333 0
DUSP22_ENST00000344450 DUSP22 Q9NRW4 Dual specificity protein phosphatase 22 chr6 GO:0043549 Not Cancer Driver No 84 0.457 0 0 0.0 0
DVL2 DVL2 O14641 Segment polarity protein dishevelled homolog DVL-2 chr17 GO:0043549 Not Cancer Driver No 96 0.13 514 64 0.125 0
DVL3 DVL3 Q92997 Segment polarity protein dishevelled homolog DVL-3 chr3 GO:0043549 Not Cancer Driver No 97 0.135 437 58 0.133 0
DYNAP DYNAP Q8N1N2 Dynactin-associated protein chr18 GO:0043549 Not Cancer Driver No 54 0.257 78 21 0.269 0
EDN1 EDN1 P05305 Endothelin-1 chr6 GO:0043549 Not Cancer Driver No 37 0.175 97 20 0.206 3
EEF1A1 EEF1A1 P68104 Elongation factor 1-alpha 1 chr6 GO:0043549 Not Cancer Driver No 109 0.236 100 14 0.14 0
EEF1A2 EEF1A2 Q05639 Elongation factor 1-alpha 2 chr20 GO:0043549 Not Cancer Driver No 74 0.16 121 17 0.14 3
EFNA1 EFNA1 P20827 Ephrin-A1 chr1 GO:0043549 Not Cancer Driver No 29 0.141 46 5 0.109 0
EFNA5 EFNA5 P52803 Ephrin-A5 chr5 GO:0043549 Not Cancer Driver No 34 0.149 25 6 0.24 0
EGF EGF P01133 Pro-epidermal growth factor chr4 GO:0043549 Not Cancer Driver No 184 0.152 191 25 0.131 1
EGFR EGFR P00533 Epidermal growth factor receptor chr7 GO:0043549 Census, Compendium Yes 444 0.367 223 35 0.157 1
EGR1 EGR1 P18146 Early growth response protein 1 chr5 GO:0043549 Not Cancer Driver No 78 0.144 501 72 0.144 0
EMP2_ENST00000536829 EMP2 P54851 Epithelial membrane protein 2 chr16 GO:0043549 Not Cancer Driver No 24 0.144 0 0 0.0 2
EPGN EPGN Q6UW88 Epigen chr4 GO:0043549 Not Cancer Driver No 16 0.104 0 0 0.0 0
EPHA4_ENST00000409938 EPHA4 P54764 Ephrin type-A receptor 4 chr2 GO:0043549 Not Cancer Driver No 182 0.185 140 24 0.171 0
EPHA8 EPHA8 P29322 Ephrin type-A receptor 8 chr1 GO:0043549 Not Cancer Driver No 197 0.196 121 17 0.14 0
ERBB3 ERBB3 P21860 Receptor tyrosine-protein kinase erbB-3 chr12 GO:0043549 Census, Compendium Yes 298 0.222 396 70 0.177 3
ERCC6 ERCC6 Q03468 DNA excision repair protein ERCC-6 chr10 GO:0043549 Not Cancer Driver No 211 0.141 829 117 0.141 9
EREG EREG O14944 Proepiregulin chr4 GO:0043549 Not Cancer Driver No 26 0.154 10 3 0.3 0
ERN1 ERN1 O75460 Serine/threonine-protein kinase/endoribonuclease IRE1 chr17 GO:0043549 Not Cancer Driver No 125 0.128 250 28 0.112 0
ERN2 ERN2 Q76MJ5 Serine/threonine-protein kinase/endoribonuclease IRE2 chr16 GO:0043549 Not Cancer Driver No 192 0.207 213 45 0.211 0
ERRFI1 ERRFI1 Q9UJM3 ERBB receptor feedback inhibitor 1 chr1 GO:0043549 Not Cancer Driver No 55 0.119 297 37 0.125 0
F2 F2 P00734 Prothrombin chr11 GO:0043549 Not Cancer Driver No 115 0.185 97 25 0.258 10
FBXO7 FBXO7 Q9Y3I1 F-box only protein 7 chr22 GO:0043549 Not Cancer Driver No 75 0.144 243 38 0.156 1
FBXW7_ENST00000603841 FBXW7 Q969H0 F-box/WD repeat-containing protein 7 chr4 GO:0043549 Census, Compendium Yes 322 0.455 230 38 0.165 0
FCGR1A FCGR1A P12314 High affinity immunoglobulin gamma Fc receptor I chr1 GO:0043549 Not Cancer Driver No 62 0.166 37 5 0.135 0
FERMT2_ENST00000395631 FERMT2 Q96AC1 Fermitin family homolog 2 chr14 GO:0043549 Not Cancer Driver No 71 0.104 101 10 0.099 0
FGD2 FGD2 Q7Z6J4 FYVE, RhoGEF and PH domain-containing protein 2 chr6 GO:0043549 Not Cancer Driver No 113 0.173 158 26 0.165 0
FGF1_ENST00000612258 FGF1 P05230 Fibroblast growth factor 1 chr5 GO:0043549 Not Cancer Driver No 30 0.194 29 2 0.069 0
FGF2_ENST00000614010 FGF2 P09038 Fibroblast growth factor 2 chr4 GO:0043549 Not Cancer Driver No 18 0.062 183 5 0.027 0
FGFR1OP CEP43 O95684 Centrosomal protein 43 chr6 GO:0043549 Not Cancer Driver No 43 0.108 272 33 0.121 0
FGFR3_ENST00000440486 FGFR3 P22607 Fibroblast growth factor receptor 3 chr4 GO:0043549 Census, Compendium Yes 173 0.215 241 26 0.108 37
FGR_ENST00000374004 FGR P09769 Tyrosine-protein kinase Fgr chr1 GO:0043549 Not Cancer Driver No 85 0.161 52 8 0.154 0
FLT1 FLT1 P17948 Vascular endothelial growth factor receptor 1 chr13 GO:0043549 Not Cancer Driver No 299 0.223 103 20 0.194 0
FLT3 FLT3 P36888 Receptor-type tyrosine-protein kinase FLT3 chr13 GO:0043549 Census, Compendium Yes 200 0.201 64 27 0.422 0
FOXA2_ENST00000377115 FOXA2 Q9Y261 Hepatocyte nuclear factor 3-beta chr20 GO:0043549 Compendium Yes 70 0.153 258 34 0.132 0
FPR2 FPR2 P25090 N-formyl peptide receptor 2 chr19 GO:0043549 Not Cancer Driver No 96 0.274 26 5 0.192 0
FZD10 FZD10 Q9ULW2 Frizzled-10 chr12 GO:0043549 Not Cancer Driver No 148 0.255 65 15 0.231 0
FZD4 FZD4 Q9ULV1 Frizzled-4 chr11 GO:0043549 Not Cancer Driver No 57 0.106 33 5 0.152 19
FZD5 FZD5 Q13467 Frizzled-5 chr2 GO:0043549 Not Cancer Driver No 45 0.077 58 4 0.069 0
FZD8 FZD8 Q9H461 Frizzled-8 chr10 GO:0043549 Not Cancer Driver No 72 0.104 146 3 0.021 0
GADD45A GADD45A P24522 Growth arrest and DNA damage-inducible protein GADD45 alpha chr1 GO:0043549 Not Cancer Driver No 10 0.061 39 5 0.128 0
GAS6 GAS6 Q14393 Growth arrest-specific protein 6 chr13 GO:0043549 Not Cancer Driver No 82 0.121 42 6 0.143 0
GCKR GCKR Q14397 Glucokinase regulatory protein chr2 GO:0043549 Not Cancer Driver No 98 0.157 85 27 0.318 0
GH1 GH1 P01241 Somatotropin chr17 GO:0043549 Not Cancer Driver No 54 0.249 24 9 0.375 15
GHRL_ENST00000457360 GHRL Q9UBU3 Appetite-regulating hormone chr3 GO:0043549 Not Cancer Driver No 20 0.171 52 11 0.212 0
GHR_ENST00000612382 GHR P10912 Growth hormone receptor chr5 GO:0043549 Not Cancer Driver No 173 0.271 229 66 0.288 19
GPRC5A GPRC5A Q8NFJ5 Retinoic acid-induced protein 3 chr12 GO:0043549 Not Cancer Driver No 43 0.12 19 4 0.211 0
GPRC5B_ENST00000569479 GPRC5B Q9NZH0 G-protein coupled receptor family C group 5 member B chr16 GO:0043549 Not Cancer Driver No 82 0.203 75 19 0.253 0
GREM1 GREM1 O60565 Gremlin-1 chr15 GO:0043549 Not Cancer Driver No 25 0.136 77 12 0.156 0
GRM5 GRM5 P41594 Metabotropic glutamate receptor 5 chr11 GO:0043549 Not Cancer Driver No 312 0.257 323 51 0.158 0
GSTP1_ENST00000642444 GSTP1 P09211 Glutathione S-transferase P chr11 GO:0043549 Not Cancer Driver No 32 0.152 0 0 0.0 0
H2AFY MACROH2A1 O75367 Core histone macro-H2A.1 chr5 GO:0043549 Not Cancer Driver No 46 0.124 125 19 0.152 0
HBEGF HBEGF Q99075 Proheparin-binding EGF-like growth factor chr5 GO:0043549 Not Cancer Driver No 16 0.077 63 3 0.048 0
HEG1 HEG1 Q9ULI3 Protein HEG homolog 1 chr3 GO:0043549 Not Cancer Driver No 173 0.125 974 135 0.139 0
HEXIM1 HEXIM1 O94992 Protein HEXIM1 chr17 GO:0043549 Not Cancer Driver No 40 0.111 352 40 0.114 0
HEXIM2_ENST00000592695 HEXIM2 Q96MH2 Protein HEXIM2 chr17 GO:0043549 Not Cancer Driver No 35 0.122 286 35 0.122 0
HGF_ENST00000644543 HGF P14210 Hepatocyte growth factor chr7 GO:0043549 Compendium Yes 233 0.32 43 16 0.372 0
HHEX HHEX Q03014 Hematopoietically-expressed homeobox protein HHEX chr10 GO:0043549 Not Cancer Driver No 23 0.085 193 21 0.109 0
HIPK3 HIPK3 Q9H422 Homeodomain-interacting protein kinase 3 chr11 GO:0043549 Not Cancer Driver No 128 0.105 559 51 0.091 0
HSP90AA1_ENST00000216281 HSP90AA1 P07900 Heat shock protein HSP 90-alpha chr14 GO:0043549 Census, Compendium Yes 106 0.145 257 37 0.144 0
HSP90AB1 HSP90AB1 P08238 Heat shock protein HSP 90-beta chr6 GO:0043549 Census, Compendium Yes 100 0.138 254 43 0.169 0
HTT HTT P42858 Huntingtin chr4 GO:0043549 Not Cancer Driver No 336 0.107 666 69 0.104 2
HYAL2_ENST00000357750 HYAL2 Q12891 Hyaluronidase-2 chr3 GO:0043549 Not Cancer Driver No 52 0.11 8 1 0.125 0
IBTK IBTK Q9P2D0 Inhibitor of Bruton tyrosine kinase chr6 GO:0043549 Not Cancer Driver No 146 0.108 364 39 0.107 0
IFNG IFNG P01579 Interferon gamma chr12 GO:0043549 Not Cancer Driver No 51 0.307 23 6 0.261 0
IGF1_ENST00000307046 IGF1 P05019 Insulin-like growth factor I chr12 GO:0043549 Not Cancer Driver No 45 0.231 87 23 0.264 0
IL12B IL12B P29460 Interleukin-12 subunit beta chr5 GO:0043549 Not Cancer Driver No 48 0.146 42 2 0.048 0
IL18 IL18 Q14116 Interleukin-18 chr11 GO:0043549 Not Cancer Driver No 19 0.098 16 3 0.188 0
IL1B IL1B P01584 Interleukin-1 beta chr2 GO:0043549 Not Cancer Driver No 39 0.145 16 3 0.188 0
IL23A IL23A Q9NPF7 Interleukin-23 subunit alpha chr12 GO:0043549 Not Cancer Driver No 15 0.079 42 3 0.071 0
IL23R IL23R Q5VWK5 Interleukin-23 receptor chr1 GO:0043549 Not Cancer Driver No 70 0.111 117 19 0.162 0
IL34 IL34 Q6ZMJ4 Interleukin-34 chr16 GO:0043549 Not Cancer Driver No 22 0.091 42 6 0.143 0
IL4 IL4 P05112 Interleukin-4 chr5 GO:0043549 Not Cancer Driver No 18 0.118 0 0 0.0 0
IL6R IL6R P08887 Interleukin-6 receptor subunit alpha chr1 GO:0043549 Not Cancer Driver No 55 0.118 165 23 0.139 1
INCA1_ENST00000576820 INCA1 Q0VD86 Protein INCA1 chr17 GO:0043549 Not Cancer Driver No 18 0.076 195 14 0.072 0
INS INS P01308 Insulin chr11 GO:0043549 Not Cancer Driver No 15 0.136 5 1 0.2 22
INSR INSR P06213 Insulin receptor chr19 GO:0043549 Not Cancer Driver No 190 0.137 280 57 0.204 64
IPO5_ENST00000490680 IPO5 O00410 Importin-5 chr13 GO:0043549 Not Cancer Driver No 128 0.117 52 3 0.058 0
IPO7 IPO7 O95373 Importin-7 chr11 GO:0043549 Not Cancer Driver No 138 0.133 202 30 0.149 0
IRAK1 IRAK1 P51617 Interleukin-1 receptor-associated kinase 1 chrX GO:0043549 Compendium Yes 71 0.1 337 39 0.116 0
IRS1 IRS1 P35568 Insulin receptor substrate 1 chr2 GO:0043549 Not Cancer Driver No 161 0.13 1072 133 0.124 2
ITGB1BP1_ENST00000355346 ITGB1BP1 O14713 Integrin beta-1-binding protein 1 chr2 GO:0043549 Not Cancer Driver No 26 0.13 58 11 0.19 0
JAK2 JAK2 O60674 Tyrosine-protein kinase JAK2 chr9 GO:0043549 Census, Compendium Yes 136 0.12 59 5 0.085 5
KAT2B KAT2B Q92831 Histone acetyltransferase KAT2B chr3 GO:0043549 Not Cancer Driver No 107 0.129 266 27 0.102 0
KIT KIT P10721 Mast/stem cell growth factor receptor Kit chr4 GO:0043549 Census, Compendium Yes 226 0.232 83 33 0.398 21
LATS1 LATS1 O95835 Serine/threonine-protein kinase LATS1 chr6 GO:0043549 Census, Compendium Yes 161 0.142 788 100 0.127 0
LATS2 LATS2 Q9NRM7 Serine/threonine-protein kinase LATS2 chr13 GO:0043549 Census, Compendium Yes 178 0.164 687 116 0.169 0
LDB1 LDB1 Q86U70 LIM domain-binding protein 1 chr10 GO:0043549 Compendium Yes 56 0.136 177 29 0.164 0
LDB2 LDB2 O43679 LIM domain-binding protein 2 chr4 GO:0043549 Not Cancer Driver No 122 0.327 145 54 0.372 0
LEP LEP P41159 Leptin chr7 GO:0043549 Not Cancer Driver No 29 0.174 0 0 0.0 2
LILRA5 LILRA5 A6NI73 Leukocyte immunoglobulin-like receptor subfamily A member 5 chr19 GO:0043549 Not Cancer Driver No 79 0.264 98 19 0.194 0
LILRB4 LILRB4 Q8NHJ6 Leukocyte immunoglobulin-like receptor subfamily B member 4 chr19 GO:0043549 Not Cancer Driver No 162 0.362 277 115 0.415 0
LRP5 LRP5 O75197 Low-density lipoprotein receptor-related protein 5 chr11 GO:0043549 Not Cancer Driver No 253 0.157 188 28 0.149 55
LRP6 LRP6 O75581 Low-density lipoprotein receptor-related protein 6 chr12 GO:0043549 Not Cancer Driver No 206 0.128 255 30 0.118 5
LRP8 LRP8 Q14114 Low-density lipoprotein receptor-related protein 8 chr1 GO:0043549 Not Cancer Driver No 94 0.098 190 24 0.126 0
LYN LYN P07948 Tyrosine-protein kinase Lyn chr8 GO:0043549 Census Yes 95 0.186 84 12 0.143 0
MALT1 MALT1 Q9UDY8 Mucosa-associated lymphoid tissue lymphoma translocation protein 1 chr18 GO:0043549 Census, Compendium Yes 75 0.091 139 12 0.086 1
MAP2K7_ENST00000397979 MAP2K7 O14733 Dual specificity mitogen-activated protein kinase kinase 7 chr19 GO:0043549 Compendium Yes 89 0.212 144 20 0.139 0
MAP3K10 MAP3K10 Q02779 Mitogen-activated protein kinase kinase kinase 10 chr19 GO:0043549 Not Cancer Driver No 112 0.117 589 62 0.105 0
MAP3K11 MAP3K11 Q16584 Mitogen-activated protein kinase kinase kinase 11 chr11 GO:0043549 Not Cancer Driver No 97 0.115 466 54 0.116 0
MAP3K12_ENST00000267079 MAP3K12 Q12852 Mitogen-activated protein kinase kinase kinase 12 chr12 GO:0043549 Not Cancer Driver No 120 0.14 481 64 0.133 0
MAP3K13_ENST00000424227 MAP3K13 O43283 Mitogen-activated protein kinase kinase kinase 13 chr3 GO:0043549 Census Yes 157 0.163 593 91 0.153 0
MAP3K4 MAP3K4 Q9Y6R4 Mitogen-activated protein kinase kinase kinase 4 chr6 GO:0043549 Not Cancer Driver No 261 0.162 520 86 0.165 0
MAP3K5 MAP3K5 Q99683 Mitogen-activated protein kinase kinase kinase 5 chr6 GO:0043549 Not Cancer Driver No 197 0.143 242 29 0.12 0
MAP3K7 MAP3K7 O43318 Mitogen-activated protein kinase kinase kinase 7 chr6 GO:0043549 Not Cancer Driver No 104 0.172 333 66 0.198 6
MAP4K2 MAP4K2 Q12851 Mitogen-activated protein kinase kinase kinase kinase 2 chr11 GO:0043549 Not Cancer Driver No 78 0.095 243 23 0.095 0
MAPK8IP1 MAPK8IP1 Q9UQF2 C-Jun-amino-terminal kinase-interacting protein 1 chr11 GO:0043549 Not Cancer Driver No 79 0.111 444 40 0.09 1
MAPRE3 MAPRE3 Q9UPY8 Microtubule-associated protein RP/EB family member 3 chr2 GO:0043549 Not Cancer Driver No 37 0.132 120 16 0.133 0
MAPT_ENST00000262410 MAPT P10636 Microtubule-associated protein tau chr17 GO:0043549 Not Cancer Driver No 128 0.169 750 126 0.168 18
MAS1 MAS1 P04201 Proto-oncogene Mas chr6 GO:0043549 Not Cancer Driver No 47 0.145 5 2 0.4 0
MCPH1 MCPH1 Q8NEM0 Microcephalin chr8 GO:0043549 Not Cancer Driver No 110 0.132 446 62 0.139 1
MEN1 MEN1 O00255 Menin chr11 GO:0043549 Census, Compendium Yes 73 0.119 228 15 0.066 90
MIDN MIDN Q504T8 Midnolin chr19 GO:0043549 Not Cancer Driver No 43 0.092 446 43 0.096 0
MNAT1 MNAT1 P51948 CDK-activating kinase assembly factor MAT1 chr14 GO:0043549 Not Cancer Driver No 23 0.074 64 2 0.031 0
MST1 MST1 P26927 Hepatocyte growth factor-like protein chr3 GO:0043549 Not Cancer Driver No 110 0.155 168 19 0.113 0
MT3 MT3 P25713 Metallothionein-3 chr16 GO:0043549 Not Cancer Driver No 7 0.103 0 0 0.0 0
MTOR MTOR P42345 Serine/threonine-protein kinase mTOR chr1 GO:0043549 Census, Compendium Yes 379 0.149 296 37 0.125 18
MVP MVP Q14764 Major vault protein chr16 GO:0043549 Not Cancer Driver No 141 0.158 285 31 0.109 0
MYOCD_ENST00000343344 MYOCD Q8IZQ8 Myocardin chr17 GO:0043549 Not Cancer Driver No 284 0.303 853 263 0.308 0
NAB2 NAB2 Q15742 NGFI-A-binding protein 2 chr12 GO:0043549 Census Yes 67 0.128 395 51 0.129 0
NCAPG2_ENST00000356309 NCAPG2 Q86XI2 Condensin-2 complex subunit G2 chr7 GO:0043549 Not Cancer Driver No 113 0.099 72 8 0.111 3
NCF1 NCF1 P14598 Neutrophil cytosol factor 1 chr7 GO:0043549 Not Cancer Driver No 37 0.095 181 12 0.066 1
NCK2_ENST00000393349 NCK2 O43639 Cytoplasmic protein NCK2 chr2 GO:0043549 Not Cancer Driver No 89 0.234 88 19 0.216 0
NEDD9 NEDD9 Q14511 Enhancer of filamentation 1 chr6 GO:0043549 Not Cancer Driver No 106 0.127 516 72 0.14 0
NEURL1 NEURL1 O76050 E3 ubiquitin-protein ligase NEURL1 chr10 GO:0043549 Not Cancer Driver No 62 0.108 153 11 0.072 0
NLRC5_ENST00000436936 NLRC5 Q86WI3 Protein NLRC5 chr16 GO:0043549 Not Cancer Driver No 262 0.14 114 19 0.167 0
NOD2 NOD2 Q9HC29 Nucleotide-binding oligomerization domain-containing protein 2 chr16 GO:0043549 Not Cancer Driver No 169 0.163 40 4 0.1 15
NOX4 NOX4 Q9NPH5 NADPH oxidase 4 chr11 GO:0043549 Not Cancer Driver No 123 0.213 0 0 0.0 0
NPFFR2 NPFFR2 Q9Y5X5 Neuropeptide FF receptor 2 chr4 GO:0043549 Not Cancer Driver No 154 0.295 57 20 0.351 0
NPM1 NPM1 P06748 Nucleophosmin chr5 GO:0043549 Census, Compendium Yes 29 0.099 249 22 0.088 0
NPPA NPPA P01160 Natriuretic peptides A chr1 GO:0043549 Not Cancer Driver No 32 0.212 71 14 0.197 1
NR2F2 NR2F2 P24468 COUP transcription factor 2 chr15 GO:0043549 Not Cancer Driver No 66 0.159 101 1 0.01 5
NRBF2 NRBF2 Q96F24 Nuclear receptor-binding factor 2 chr10 GO:0043549 Not Cancer Driver No 34 0.118 224 25 0.112 0
NRG1_ENST00000405005 NRG1 Q02297 Pro-neuregulin-1, membrane-bound isoform chr8 GO:0043549 Census, Compendium Yes 159 0.248 528 132 0.25 0
NRG3_ENST00000404547 NRG3 P56975 Pro-neuregulin-3, membrane-bound isoform chr10 GO:0043549 Not Cancer Driver No 227 0.315 425 134 0.315 0
NTF3_ENST00000331010 NTF3 P20783 Neurotrophin-3 chr12 GO:0043549 Not Cancer Driver No 52 0.202 99 21 0.212 0
NTRK3_ENST00000629765 NTRK3 Q16288 NT-3 growth factor receptor chr15 GO:0043549 Census, Compendium Yes 249 0.297 57 21 0.368 0
OSBPL8 OSBPL8 Q9BZF1 Oxysterol-binding protein-related protein 8 chr12 GO:0043549 Not Cancer Driver No 105 0.118 401 37 0.092 0
P2RY12 P2RY12 Q9H244 P2Y purinoceptor 12 chr3 GO:0043549 Not Cancer Driver No 57 0.167 21 2 0.095 3
PAK1_ENST00000356341 PAK1 Q13153 Serine/threonine-protein kinase PAK 1 chr11 GO:0043549 Not Cancer Driver No 57 0.105 299 30 0.1 2
PAK2 PAK2 Q13177 Serine/threonine-protein kinase PAK 2 chr3 GO:0043549 Compendium Yes 89 0.17 242 49 0.202 0
PARK7_ENST00000377488 PARK7 Q99497 Parkinson disease protein 7 chr1 GO:0043549 Not Cancer Driver No 11 0.058 30 0 0.0 5
PDCD4 PDCD4 Q53EL6 Programmed cell death protein 4 chr10 GO:0043549 Not Cancer Driver No 57 0.122 187 32 0.171 0
PDGFB PDGFB P01127 Platelet-derived growth factor subunit B chr22 GO:0043549 Census Yes 37 0.154 99 22 0.222 2
PDGFC PDGFC Q9NRA1 Platelet-derived growth factor C chr4 GO:0043549 Not Cancer Driver No 86 0.249 53 12 0.226 0
PDGFRA PDGFRA P16234 Platelet-derived growth factor receptor alpha chr4 GO:0043549 Census, Compendium Yes 290 0.266 173 45 0.26 2
PDGFRB PDGFRB P09619 Platelet-derived growth factor receptor beta chr5 GO:0043549 Census, Compendium Yes 164 0.148 231 44 0.19 7
PDPK1 PDPK1 O15530 3-phosphoinositide-dependent protein kinase 1 chr16 GO:0043549 Not Cancer Driver No 33 0.059 121 12 0.099 0
PFKFB1 PFKFB1 P16118 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 chrX GO:0043549 Not Cancer Driver No 81 0.172 48 11 0.229 0
PFKFB2 PFKFB2 O60825 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 chr1 GO:0043549 Not Cancer Driver No 68 0.135 97 18 0.186 0
PHB2 PHB2 Q99623 Prohibitin-2 chr12 GO:0043549 Not Cancer Driver No 31 0.104 26 4 0.154 0
PHB_ENST00000300408 PHB1 P35232 Prohibitin 1 chr17 GO:0043549 Not Cancer Driver No 37 0.136 4 1 0.25 0
PIBF1 PIBF1 Q8WXW3 Progesterone-induced-blocking factor 1 chr13 GO:0043549 Not Cancer Driver No 83 0.11 419 45 0.107 2
PIK3IP1 PIK3IP1 Q96FE7 Phosphoinositide-3-kinase-interacting protein 1 chr22 GO:0043549 Not Cancer Driver No 27 0.103 128 13 0.102 0
PIK3R1 PIK3R1 P27986 Phosphatidylinositol 3-kinase regulatory subunit alpha chr5 GO:0043549 Census, Compendium Yes 154 0.213 268 61 0.228 2
PIK3R2_ENST00000617130 PIK3R2 O00459 Phosphatidylinositol 3-kinase regulatory subunit beta chr19 GO:0043549 Not Cancer Driver No 96 0.132 418 47 0.112 3
PIK3R3_ENST00000372006 PIK3R3 Q92569 Phosphatidylinositol 3-kinase regulatory subunit gamma chr1 GO:0043549 Not Cancer Driver No 51 0.111 149 20 0.134 0
PIK3R4 PIK3R4 Q99570 Phosphoinositide 3-kinase regulatory subunit 4 chr3 GO:0043549 Not Cancer Driver No 193 0.142 315 45 0.143 0
PIK3R5 PIK3R5 Q8WYR1 Phosphoinositide 3-kinase regulatory subunit 5 chr17 GO:0043549 Not Cancer Driver No 143 0.163 316 55 0.174 1
PIK3R6_ENST00000614407 PIK3R6 Q5UE93 Phosphoinositide 3-kinase regulatory subunit 6 chr17 GO:0043549 Not Cancer Driver No 100 0.133 156 26 0.167 0
PILRB PILRB Q9UKJ0 Paired immunoglobulin-like type 2 receptor beta chr7 GO:0043549 Not Cancer Driver No 29 0.128 26 3 0.115 0
PINK1 PINK1 Q9BXM7 Serine/threonine-protein kinase PINK1, mitochondrial chr1 GO:0043549 Not Cancer Driver No 57 0.098 99 13 0.131 23
PIP4K2A PIP4K2A P48426 Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha chr10 GO:0043549 Not Cancer Driver No 56 0.138 123 15 0.122 0
PIP4K2C_ENST00000540759 PIP4K2C Q8TBX8 Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma chr12 GO:0043549 Not Cancer Driver No 62 0.147 111 23 0.207 0
PKD1 PKD1 P98161 Polycystin-1 chr16 GO:0043549 Not Cancer Driver No 393 0.091 690 66 0.096 92
PKD2 PKD2 Q13563 Polycystin-2 chr4 GO:0043549 Not Cancer Driver No 113 0.117 375 35 0.093 10
PKIA PKIA P61925 cAMP-dependent protein kinase inhibitor alpha chr8 GO:0043549 Not Cancer Driver No 18 0.237 76 18 0.237 0
PKIB_ENST00000368448 PKIB Q9C010 cAMP-dependent protein kinase inhibitor beta chr6 GO:0043549 Not Cancer Driver No 13 0.167 78 13 0.167 0
PKIG_ENST00000372891 PKIG Q9Y2B9 cAMP-dependent protein kinase inhibitor gamma chr20 GO:0043549 Not Cancer Driver No 15 0.197 76 15 0.197 0
PLGLB2 PLGLB2 Q02325 Plasminogen-like protein B chr2 GO:0043549 Not Cancer Driver No 2 0.021 0 0 0.0 0
PLK1 PLK1 P53350 Serine/threonine-protein kinase PLK1 chr16 GO:0043549 Not Cancer Driver No 87 0.144 119 13 0.109 0
PPEF2 PPEF2 O14830 Serine/threonine-protein phosphatase with EF-hands 2 chr4 GO:0043549 Not Cancer Driver No 144 0.191 130 29 0.223 0
PPIA PPIA P62937 Peptidyl-prolyl cis-trans isomerase A chr7 GO:0043549 Not Cancer Driver No 11 0.067 24 3 0.125 0
PPM1F PPM1F P49593 Protein phosphatase 1F chr22 GO:0043549 Not Cancer Driver No 53 0.117 242 24 0.099 0
PPP1R1B PPP1R1B Q9UD71 Protein phosphatase 1 regulatory subunit 1B chr17 GO:0043549 Not Cancer Driver No 30 0.147 204 30 0.147 0
PPP2R5A PPP2R5A Q15172 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform chr1 GO:0043549 Not Cancer Driver No 55 0.113 93 5 0.054 0
PRKAG2 PRKAG2 Q9UGJ0 5'-AMP-activated protein kinase subunit gamma-2 chr7 GO:0043549 Not Cancer Driver No 76 0.134 240 45 0.188 7
PRKAR1A_ENST00000536854 PRKAR1A P10644 cAMP-dependent protein kinase type I-alpha regulatory subunit chr17 GO:0043549 Census, Compendium Yes 39 0.102 66 11 0.167 17
PRKAR1B_ENST00000403562 PRKAR1B P31321 cAMP-dependent protein kinase type I-beta regulatory subunit chr7 GO:0043549 Not Cancer Driver No 53 0.139 71 13 0.183 0
PRKAR2A PRKAR2A P13861 cAMP-dependent protein kinase type II-alpha regulatory subunit chr3 GO:0043549 Not Cancer Driver No 37 0.092 149 13 0.087 0
PRKAR2B PRKAR2B P31323 cAMP-dependent protein kinase type II-beta regulatory subunit chr7 GO:0043549 Not Cancer Driver No 60 0.144 125 4 0.032 0
PRKCZ PRKCZ Q05513 Protein kinase C zeta type chr1 GO:0043549 Not Cancer Driver No 70 0.118 116 11 0.095 0
PRKD1_ENST00000616995 PRKD1 Q15139 Serine/threonine-protein kinase D1 chr14 GO:0043549 Census Yes 201 0.22 189 33 0.175 2
PRKN PRKN O60260 E3 ubiquitin-protein ligase parkin chr6 GO:0043549 Not Cancer Driver No 110 0.237 78 15 0.192 31
PRLR PRLR P16471 Prolactin receptor chr5 GO:0043549 Not Cancer Driver No 154 0.248 282 70 0.248 2
PRNP PRNP P04156 Major prion protein chr20 GO:0043549 Not Cancer Driver No 36 0.142 115 7 0.061 18
PROX1 PROX1 Q92786 Prospero homeobox protein 1 chr1 GO:0043549 Not Cancer Driver No 182 0.247 537 141 0.263 0
PRRC1_ENST00000296666 PRRC1 Q96M27 Protein PRRC1 chr5 GO:0043549 Not Cancer Driver No 42 0.094 235 24 0.102 0
PSEN1 PSEN1 P49768 Presenilin-1 chr14 GO:0043549 Not Cancer Driver No 61 0.131 134 21 0.157 96
PSMD10 PSMD10 O75832 26S proteasome non-ATPase regulatory subunit 10 chrX GO:0043549 Not Cancer Driver No 20 0.088 53 5 0.094 0
PSRC1_ENST00000409138 PSRC1 Q6PGN9 Proline/serine-rich coiled-coil protein 1 chr1 GO:0043549 Not Cancer Driver No 30 0.083 361 30 0.083 0
PTEN PTEN P60484 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN chr10 GO:0043549 Census, Compendium Yes 505 1.253 76 4 0.053 41
PTK2B_ENST00000346049 PTK2B Q14289 Protein-tyrosine kinase 2-beta chr8 GO:0043549 Not Cancer Driver No 161 0.16 261 37 0.142 0
PTK2_ENST00000522684 PTK2 Q05397 Focal adhesion kinase 1 chr8 GO:0043549 Not Cancer Driver No 134 0.127 425 55 0.129 0
PTK6 PTK6 Q13882 Protein-tyrosine kinase 6 chr20 GO:0043549 Census Yes 42 0.093 12 0 0.0 0
PTPN1 PTPN1 P18031 Tyrosine-protein phosphatase non-receptor type 1 chr20 GO:0043549 Not Cancer Driver No 49 0.113 140 25 0.179 0
PTPN2 PTPN2 P17706 Tyrosine-protein phosphatase non-receptor type 2 chr18 GO:0043549 Not Cancer Driver No 57 0.137 120 14 0.117 0
PTPN22 PTPN22 Q9Y2R2 Tyrosine-protein phosphatase non-receptor type 22 chr1 GO:0043549 Not Cancer Driver No 141 0.175 364 62 0.17 4
PTPRC PTPRC P08575 Receptor-type tyrosine-protein phosphatase C chr1 GO:0043549 Census, Compendium Yes 315 0.241 462 107 0.232 0
PYCARD PYCARD Q9ULZ3 Apoptosis-associated speck-like protein containing a CARD chr16 GO:0043549 Not Cancer Driver No 16 0.082 39 4 0.103 0
RACK1 RACK1 P63244 Receptor of activated protein C kinase 1 chr5 GO:0043549 Not Cancer Driver No 34 0.107 13 0 0.0 0
RANBP2 RANBP2 P49792 E3 SUMO-protein ligase RanBP2 chr2 GO:0043549 Census, Compendium Yes 427 0.132 1387 177 0.128 3
RAP2B RAP2B P61225 Ras-related protein Rap-2b chr3 GO:0043549 Not Cancer Driver No 22 0.12 0 0 0.0 0
RAP2C_ENST00000370874 RAP2C Q9Y3L5 Ras-related protein Rap-2c chrX GO:0043549 Not Cancer Driver No 32 0.175 8 2 0.25 0
RAPGEF2 RAPGEF2 Q9Y4G8 Rap guanine nucleotide exchange factor 2 chr4 GO:0043549 Not Cancer Driver No 216 0.144 803 116 0.144 0
RASIP1 RASIP1 Q5U651 Ras-interacting protein 1 chr19 GO:0043549 Not Cancer Driver No 73 0.076 505 48 0.095 0
RB1 RB1 P06400 Retinoblastoma-associated protein chr13 GO:0043549 Census, Compendium Yes 140 0.151 282 32 0.113 22
RBL1 RBL1 P28749 Retinoblastoma-like protein 1 chr20 GO:0043549 Not Cancer Driver No 140 0.131 335 41 0.122 0
RBL2 RBL2 Q08999 Retinoblastoma-like protein 2 chr16 GO:0043549 Not Cancer Driver No 116 0.102 504 56 0.111 0
RELN RELN P78509 Reelin chr7 GO:0043549 Not Cancer Driver No 761 0.22 107 19 0.178 7
RGCC RGCC Q9H4X1 Regulator of cell cycle RGCC chr13 GO:0043549 Not Cancer Driver No 9 0.066 81 7 0.086 0
ROR2 ROR2 Q01974 Tyrosine-protein kinase transmembrane receptor ROR2 chr9 GO:0043549 Not Cancer Driver No 203 0.215 299 71 0.237 5
RPS3_ENST00000527446 RPS3 P23396 40S ribosomal protein S3 chr11 GO:0043549 Not Cancer Driver No 22 0.091 48 4 0.083 0
RUBCN RUBCN Q92622 Run domain Beclin-1-interacting and cysteine-rich domain-containing protein chr3 GO:0043549 Not Cancer Driver No 147 0.151 403 57 0.141 0
SASH1 SASH1 O94885 SAM and SH3 domain-containing protein 1 chr6 GO:0043549 Not Cancer Driver No 174 0.14 1071 153 0.143 7
SERPINB3 SERPINB3 P29508 Serpin B3 chr18 GO:0043549 Not Cancer Driver No 142 0.364 47 28 0.596 0
SESN2 SESN2 P58004 Sestrin-2 chr1 GO:0043549 Not Cancer Driver No 74 0.154 147 26 0.177 0
SFRP1 SFRP1 Q8N474 Secreted frizzled-related protein 1 chr8 GO:0043549 Not Cancer Driver No 40 0.127 39 7 0.179 0
SFRP2 SFRP2 Q96HF1 Secreted frizzled-related protein 2 chr4 GO:0043549 Not Cancer Driver No 47 0.159 1 0 0.0 0
SH3BP5 SH3BP5 O60239 SH3 domain-binding protein 5 chr3 GO:0043549 Not Cancer Driver No 46 0.101 378 35 0.093 0
SH3BP5L SH3BP5L Q7L8J4 SH3 domain-binding protein 5-like chr1 GO:0043549 Not Cancer Driver No 62 0.158 376 57 0.152 0
SHC1_ENST00000368445 SHC1 P29353 SHC-transforming protein 1 chr1 GO:0043549 Not Cancer Driver No 84 0.144 397 58 0.146 0
SIRT1 SIRT1 Q96EB6 NAD-dependent protein deacetylase sirtuin-1 chr10 GO:0043549 Not Cancer Driver No 70 0.094 435 31 0.071 0
SLA2 SLA2 Q9H6Q3 Src-like-adapter 2 chr20 GO:0043549 Not Cancer Driver No 32 0.123 43 9 0.209 0
SLAMF8 SLAMF8 Q9P0V8 SLAM family member 8 chr1 GO:0043549 Not Cancer Driver No 63 0.221 20 2 0.1 0
SLC1A1 SLC1A1 P43005 Excitatory amino acid transporter 3 chr9 GO:0043549 Not Cancer Driver No 69 0.132 17 4 0.235 1
SLC8A1_ENST00000332839 SLC8A1 P32418 Sodium/calcium exchanger 1 chr2 GO:0043549 Not Cancer Driver No 305 0.313 158 48 0.304 0
SLC8A3 SLC8A3 P57103 Sodium/calcium exchanger 3 chr14 GO:0043549 Not Cancer Driver No 263 0.284 152 35 0.23 0
SNX6 SNX6 Q9UNH7 Sorting nexin-6 chr14 GO:0043549 Not Cancer Driver No 33 0.081 85 7 0.082 0
SOCS1 SOCS1 O15524 Suppressor of cytokine signaling 1 chr16 GO:0043549 Census, Compendium Yes 22 0.104 66 3 0.045 2
SOCS2_ENST00000536696 SOCS2 O14508 Suppressor of cytokine signaling 2 chr12 GO:0043549 Not Cancer Driver No 32 0.162 61 2 0.033 0
SOCS3 SOCS3 O14543 Suppressor of cytokine signaling 3 chr17 GO:0043549 Not Cancer Driver No 27 0.12 111 14 0.126 0
SOCS4_ENST00000555846 SOCS4 Q8WXH5 Suppressor of cytokine signaling 4 chr14 GO:0043549 Not Cancer Driver No 43 0.098 136 13 0.096 0
SOCS5 SOCS5 O75159 Suppressor of cytokine signaling 5 chr2 GO:0043549 Not Cancer Driver No 84 0.157 297 46 0.155 0
SOCS6_ENST00000582322 SOCS6 O14544 Suppressor of cytokine signaling 6 chr18 GO:0043549 Not Cancer Driver No 81 0.151 299 48 0.161 0
SORL1 SORL1 Q92673 Sortilin-related receptor chr11 GO:0043549 Not Cancer Driver No 374 0.169 87 10 0.115 0
SPATC1L SPATC1L Q9H0A9 Speriolin-like protein chr21 GO:0043549 Not Cancer Driver No 30 0.088 179 11 0.061 0
SPDYA_ENST00000379579 SPDYA Q5MJ70 Speedy protein A chr2 GO:0043549 Not Cancer Driver No 39 0.125 119 11 0.092 0
SRC_ENST00000358208 SRC P12931 Proto-oncogene tyrosine-protein kinase Src chr20 GO:0043549 Census Yes 53 0.099 130 11 0.085 1
STAP1_ENST00000396225 STAP1 Q9ULZ2 Signal-transducing adaptor protein 1 chr4 GO:0043549 Not Cancer Driver No 66 0.224 103 18 0.175 0
STOX1_ENST00000399169 STOX1 Q6ZVD7 Storkhead-box protein 1 chr10 GO:0043549 Not Cancer Driver No 121 0.122 659 83 0.126 2
SYK_ENST00000375746 SYK P43405 Tyrosine-protein kinase SYK chr9 GO:0043549 Census Yes 96 0.151 131 27 0.206 5
TAL1 TAL1 P17542 T-cell acute lymphocytic leukemia protein 1 chr1 GO:0043549 Census Yes 54 0.163 305 53 0.174 0
TAOK3 TAOK3 Q9H2K8 Serine/threonine-protein kinase TAO3 chr12 GO:0043549 Not Cancer Driver No 123 0.137 494 64 0.13 0
TCIM TCIM Q9NR00 Transcriptional and immune response regulator chr8 GO:0043549 Not Cancer Driver No 21 0.198 33 7 0.212 0
TEK TEK Q02763 Angiopoietin-1 receptor chr9 GO:0043549 Not Cancer Driver No 219 0.195 126 22 0.175 10
TESK1_ENST00000336395 TESK1 Q15569 Dual specificity testis-specific protein kinase 1 chr9 GO:0043549 Not Cancer Driver No 63 0.101 339 35 0.103 0
TFAP4 TFAP4 Q01664 Transcription factor AP-4 chr16 GO:0043549 Compendium Yes 61 0.18 285 52 0.182 0
TGFA_ENST00000295400 TGFA P01135 Protransforming growth factor alpha chr2 GO:0043549 Not Cancer Driver No 20 0.125 0 0 0.0 0
TGFB1 TGFB1 P01137 Transforming growth factor beta-1 proprotein chr19 GO:0043549 Not Cancer Driver No 41 0.105 41 4 0.098 10
THY1 THY1 P04216 Thy-1 membrane glycoprotein chr11 GO:0043549 Not Cancer Driver No 24 0.149 5 0 0.0 0
TIGAR TIGAR Q9NQ88 Fructose-2,6-bisphosphatase TIGAR chr12 GO:0043549 Not Cancer Driver No 44 0.163 39 9 0.231 0
TIRAP_ENST00000392680 TIRAP P58753 Toll/interleukin-1 receptor domain-containing adapter protein chr11 GO:0043549 Not Cancer Driver No 28 0.127 80 6 0.075 0
TLR3 TLR3 O15455 Toll-like receptor 3 chr4 GO:0043549 Not Cancer Driver No 123 0.136 0 0 0.0 1
TLR6 TLR6 Q9Y2C9 Toll-like receptor 6 chr4 GO:0043549 Not Cancer Driver No 99 0.124 1 0 0.0 0
TLR9 TLR9 Q9NR96 Toll-like receptor 9 chr3 GO:0043549 Not Cancer Driver No 141 0.137 35 3 0.086 0
TNF TNF P01375 Tumor necrosis factor chr6 GO:0043549 Not Cancer Driver No 24 0.103 45 3 0.067 0
TNFAIP3 TNFAIP3 P21580 Tumor necrosis factor alpha-induced protein 3 chr6 GO:0043549 Census, Compendium Yes 98 0.124 231 33 0.143 1
TNFAIP8L3 TNFAIP8L3 Q5GJ75 Tumor necrosis factor alpha-induced protein 8-like protein 3 chr15 GO:0043549 Not Cancer Driver No 40 0.137 111 12 0.108 0
TNFRSF10A TNFRSF10A O00220 Tumor necrosis factor receptor superfamily member 10A chr8 GO:0043549 Not Cancer Driver No 55 0.118 174 17 0.098 0
TNFRSF10B TNFRSF10B O14763 Tumor necrosis factor receptor superfamily member 10B chr8 GO:0043549 Not Cancer Driver No 44 0.1 190 19 0.1 0
TNFRSF11A TNFRSF11A Q9Y6Q6 Tumor necrosis factor receptor superfamily member 11A chr18 GO:0043549 Not Cancer Driver No 70 0.114 285 33 0.116 0
TNFSF15 TNFSF15 O95150 Tumor necrosis factor ligand superfamily member 15 chr9 GO:0043549 Not Cancer Driver No 41 0.163 49 12 0.245 0
TNXB_ENST00000375244 TNXB P22105 Tenascin-X chr6 GO:0043549 Not Cancer Driver No 666 0.157 2794 498 0.178 5
TRAF2 TRAF2 Q12933 TNF receptor-associated factor 2 chr9 GO:0043549 Not Cancer Driver No 63 0.126 4 1 0.25 0
TRAF4 TRAF4 Q9BUZ4 TNF receptor-associated factor 4 chr17 GO:0043549 Not Cancer Driver No 42 0.089 27 1 0.037 0
TRAF6_ENST00000348124 TRAF6 Q9Y4K3 TNF receptor-associated factor 6 chr11 GO:0043549 Not Cancer Driver No 67 0.128 62 7 0.113 0
TSG101 TSG101 Q99816 Tumor susceptibility gene 101 protein chr11 GO:0043549 Not Cancer Driver No 46 0.118 159 23 0.145 0
TTBK1 TTBK1 Q5TCY1 Tau-tubulin kinase 1 chr6 GO:0043549 Not Cancer Driver No 193 0.146 1045 154 0.147 0
TXN TXN P10599 Thioredoxin chr9 GO:0043549 Not Cancer Driver No 6 0.057 0 0 0.0 0
UCN UCN P55089 Urocortin chr2 GO:0043549 Not Cancer Driver No 7 0.056 61 4 0.066 0
UNC119 UNC119 Q13432 Protein unc-119 homolog A chr17 GO:0043549 Not Cancer Driver No 20 0.083 89 4 0.045 1
VAV2 VAV2 P52735 Guanine nucleotide exchange factor VAV2 chr9 GO:0043549 Not Cancer Driver No 127 0.145 135 17 0.126 0
VAV3 VAV3 Q9UKW4 Guanine nucleotide exchange factor VAV3 chr1 GO:0043549 Not Cancer Driver No 153 0.181 102 18 0.176 0
VPS25 VPS25 Q9BRG1 Vacuolar protein-sorting-associated protein 25 chr17 GO:0043549 Not Cancer Driver No 16 0.091 10 0 0.0 0
WASHC1 WASHC1 A8K0Z3 WASH complex subunit 1 chr9 GO:0043549 Not Cancer Driver No 6 0.013 336 6 0.018 0
WDR81 WDR81 Q562E7 WD repeat-containing protein 81 chr17 GO:0043549 Not Cancer Driver No 164 0.084 721 51 0.071 1
WDR91 WDR91 A4D1P6 WD repeat-containing protein 91 chr7 GO:0043549 Not Cancer Driver No 99 0.133 206 38 0.184 0
WEE2 WEE2 P0C1S8 Wee1-like protein kinase 2 chr7 GO:0043549 Not Cancer Driver No 104 0.183 345 65 0.188 1
WNT3A WNT3A P56704 Protein Wnt-3a chr1 GO:0043549 Not Cancer Driver No 77 0.219 37 5 0.135 0
WNT5A_ENST00000474267 WNT5A P41221 Protein Wnt-5a chr3 GO:0043549 Not Cancer Driver No 66 0.174 0 0 0.0 2
ZFP91 ZFP91 Q96JP5 E3 ubiquitin-protein ligase ZFP91 chr11 GO:0043549 Not Cancer Driver No 85 0.149 383 55 0.144 0
ZFYVE28 ZFYVE28 Q9HCC9 Lateral signaling target protein 2 homolog chr4 GO:0043549 Not Cancer Driver No 132 0.149 420 67 0.16 0
ZGPAT ZGPAT Q8N5A5 Zinc finger CCCH-type with G patch domain-containing protein chr20 GO:0043549 Not Cancer Driver No 75 0.141 346 49 0.142 0
ZNF675 ZNF675 Q8TD23 Zinc finger protein 675 chr19 GO:0043549 Not Cancer Driver No 114 0.201 91 19 0.209 0