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Total number of protein in "GO:0043406" GO term:  116

Identifier
UniProt Gene
UniProt Accession
UniProt Name
Chromosome
GO term
Database
Cancer Driver
Number of missense mutations
Missense mutation per residues
Number of disordered residues
Number of mutations in disordered regions
Disordered missense mutations per residues
Number of OMIM mutation
ADAM8 ADAM8 P78325 Disintegrin and metalloproteinase domain-containing protein 8 chr10 GO:0043406 Not Cancer Driver No 82 0.1 230 13 0.057 0
ADAM9 ADAM9 Q13443 Disintegrin and metalloproteinase domain-containing protein 9 chr8 GO:0043406 Not Cancer Driver No 86 0.105 129 13 0.101 0
ADRA2A ADRA2A P08913 Alpha-2A adrenergic receptor chr10 GO:0043406 Not Cancer Driver No 67 0.144 161 10 0.062 0
AGER_ENST00000375076 AGER Q15109 Advanced glycosylation end product-specific receptor chr6 GO:0043406 Not Cancer Driver No 31 0.077 297 21 0.071 0
AJUBA AJUBA Q96IF1 LIM domain-containing protein ajuba chr14 GO:0043406 Compendium Yes 45 0.084 307 13 0.042 0
AKAP13_ENST00000394518 AKAP13 Q12802 A-kinase anchor protein 13 chr15 GO:0043406 Not Cancer Driver No 359 0.128 2091 258 0.123 0
ARHGEF5 ARHGEF5 Q12774 Rho guanine nucleotide exchange factor 5 chr7 GO:0043406 Not Cancer Driver No 170 0.106 1141 127 0.111 0
AXIN1 AXIN1 O15169 Axin-1 chr16 GO:0043406 Census, Compendium Yes 120 0.139 619 88 0.142 4
CCL19 CCL19 Q99731 C-C motif chemokine 19 chr9 GO:0043406 Not Cancer Driver No 10 0.102 7 0 0.0 0
CD40 CD40 P25942 Tumor necrosis factor receptor superfamily member 5 chr20 GO:0043406 Not Cancer Driver No 39 0.141 56 6 0.107 2
CSK_ENST00000439220 CSK P41240 Tyrosine-protein kinase CSK chr15 GO:0043406 Not Cancer Driver No 41 0.091 18 1 0.056 0
DAB2IP_ENST00000408936 DAB2IP Q5VWQ8 Disabled homolog 2-interacting protein chr9 GO:0043406 Not Cancer Driver No 131 0.11 681 68 0.1 0
DIRAS1_ENST00000585334 DIRAS1 O95057 GTP-binding protein Di-Ras1 chr19 GO:0043406 Not Cancer Driver No 38 0.192 32 5 0.156 0
DIRAS2 DIRAS2 Q96HU8 GTP-binding protein Di-Ras2 chr9 GO:0043406 Not Cancer Driver No 44 0.221 27 3 0.111 0
DKK1 DKK1 O94907 Dickkopf-related protein 1 chr10 GO:0043406 Not Cancer Driver No 58 0.218 47 8 0.17 0
DRD4 DRD4 P21917 D(4) dopamine receptor chr11 GO:0043406 Not Cancer Driver No 26 0.062 109 0 0.0 0
DUSP19 DUSP19 Q8WTR2 Dual specificity protein phosphatase 19 chr2 GO:0043406 Not Cancer Driver No 34 0.157 15 5 0.333 0
DVL2 DVL2 O14641 Segment polarity protein dishevelled homolog DVL-2 chr17 GO:0043406 Not Cancer Driver No 96 0.13 514 64 0.125 0
DVL3 DVL3 Q92997 Segment polarity protein dishevelled homolog DVL-3 chr3 GO:0043406 Not Cancer Driver No 97 0.135 437 58 0.133 0
EDN1 EDN1 P05305 Endothelin-1 chr6 GO:0043406 Not Cancer Driver No 37 0.175 97 20 0.206 3
EDN3_ENST00000371028 EDN3 P14138 Endothelin-3 chr20 GO:0043406 Not Cancer Driver No 69 0.29 140 44 0.314 3
EGF EGF P01133 Pro-epidermal growth factor chr4 GO:0043406 Not Cancer Driver No 184 0.152 191 25 0.131 1
EGFR EGFR P00533 Epidermal growth factor receptor chr7 GO:0043406 Census, Compendium Yes 444 0.367 223 35 0.157 1
ELANE_ENST00000263621 ELANE P08246 Neutrophil elastase chr19 GO:0043406 Not Cancer Driver No 39 0.146 18 3 0.167 89
EPGN EPGN Q6UW88 Epigen chr4 GO:0043406 Not Cancer Driver No 16 0.104 0 0 0.0 0
EPHA4_ENST00000409938 EPHA4 P54764 Ephrin type-A receptor 4 chr2 GO:0043406 Not Cancer Driver No 182 0.185 140 24 0.171 0
ERBB2 ERBB2 P04626 Receptor tyrosine-protein kinase erbB-2 chr17 GO:0043406 Census, Compendium Yes 275 0.219 314 41 0.131 1
ERN1 ERN1 O75460 Serine/threonine-protein kinase/endoribonuclease IRE1 chr17 GO:0043406 Not Cancer Driver No 125 0.128 250 28 0.112 0
ERN2 ERN2 Q76MJ5 Serine/threonine-protein kinase/endoribonuclease IRE2 chr16 GO:0043406 Not Cancer Driver No 192 0.207 213 45 0.211 0
ERP29 ERP29 P30040 Endoplasmic reticulum resident protein 29 chr12 GO:0043406 Not Cancer Driver No 29 0.111 34 5 0.147 0
EZH2_ENST00000460911 EZH2 Q15910 Histone-lysine N-methyltransferase EZH2 chr7 GO:0043406 Census, Compendium Yes 120 0.161 284 44 0.155 11
FGD2 FGD2 Q7Z6J4 FYVE, RhoGEF and PH domain-containing protein 2 chr6 GO:0043406 Not Cancer Driver No 113 0.173 158 26 0.165 0
FGF18 FGF18 O76093 Fibroblast growth factor 18 chr5 GO:0043406 Not Cancer Driver No 40 0.193 57 14 0.246 0
FGF1_ENST00000612258 FGF1 P05230 Fibroblast growth factor 1 chr5 GO:0043406 Not Cancer Driver No 30 0.194 29 2 0.069 0
FGF2_ENST00000614010 FGF2 P09038 Fibroblast growth factor 2 chr4 GO:0043406 Not Cancer Driver No 18 0.062 183 5 0.027 0
FGFR1_ENST00000447712 FGFR1 P11362 Fibroblast growth factor receptor 1 chr8 GO:0043406 Census, Compendium Yes 152 0.185 230 43 0.187 74
FLT1 FLT1 P17948 Vascular endothelial growth factor receptor 1 chr13 GO:0043406 Not Cancer Driver No 299 0.223 103 20 0.194 0
FLT3 FLT3 P36888 Receptor-type tyrosine-protein kinase FLT3 chr13 GO:0043406 Census, Compendium Yes 200 0.201 64 27 0.422 0
FZD10 FZD10 Q9ULW2 Frizzled-10 chr12 GO:0043406 Not Cancer Driver No 148 0.255 65 15 0.231 0
FZD4 FZD4 Q9ULV1 Frizzled-4 chr11 GO:0043406 Not Cancer Driver No 57 0.106 33 5 0.152 19
FZD5 FZD5 Q13467 Frizzled-5 chr2 GO:0043406 Not Cancer Driver No 45 0.077 58 4 0.069 0
FZD8 FZD8 Q9H461 Frizzled-8 chr10 GO:0043406 Not Cancer Driver No 72 0.104 146 3 0.021 0
GH1 GH1 P01241 Somatotropin chr17 GO:0043406 Not Cancer Driver No 54 0.249 24 9 0.375 15
GHR_ENST00000612382 GHR P10912 Growth hormone receptor chr5 GO:0043406 Not Cancer Driver No 173 0.271 229 66 0.288 19
HRAS HRAS P01112 GTPase HRas chr11 GO:0043406 Census, Compendium Yes 107 0.566 16 4 0.25 18
HTR2A HTR2A P28223 5-hydroxytryptamine receptor 2A chr13 GO:0043406 Not Cancer Driver No 105 0.223 44 8 0.182 0
HTR2B HTR2B P41595 5-hydroxytryptamine receptor 2B chr2 GO:0043406 Not Cancer Driver No 41 0.085 23 2 0.087 0
IL1B IL1B P01584 Interleukin-1 beta chr2 GO:0043406 Not Cancer Driver No 39 0.145 16 3 0.188 0
IL34 IL34 Q6ZMJ4 Interleukin-34 chr16 GO:0043406 Not Cancer Driver No 22 0.091 42 6 0.143 0
INSR INSR P06213 Insulin receptor chr19 GO:0043406 Not Cancer Driver No 190 0.137 280 57 0.204 64
IRAK1 IRAK1 P51617 Interleukin-1 receptor-associated kinase 1 chrX GO:0043406 Compendium Yes 71 0.1 337 39 0.116 0
KIT KIT P10721 Mast/stem cell growth factor receptor Kit chr4 GO:0043406 Census, Compendium Yes 226 0.232 83 33 0.398 21
KITLG KITLG P21583 Kit ligand chr12 GO:0043406 Not Cancer Driver No 48 0.176 61 9 0.148 1
LRRK2 LRRK2 Q5S007 Leucine-rich repeat serine/threonine-protein kinase 2 chr12 GO:0043406 Not Cancer Driver No 519 0.205 90 17 0.189 23
MAGED1_ENST00000326587 MAGED1 Q9Y5V3 Melanoma-associated antigen D1 chrX GO:0043406 Not Cancer Driver No 131 0.168 457 71 0.155 0
MAP2K5 MAP2K5 Q13163 Dual specificity mitogen-activated protein kinase kinase 5 chr15 GO:0043406 Not Cancer Driver No 40 0.089 85 10 0.118 0
MAP2K6 MAP2K6 P52564 Dual specificity mitogen-activated protein kinase kinase 6 chr17 GO:0043406 Not Cancer Driver No 48 0.144 55 11 0.2 0
MAP2K7_ENST00000397979 MAP2K7 O14733 Dual specificity mitogen-activated protein kinase kinase 7 chr19 GO:0043406 Compendium Yes 89 0.212 144 20 0.139 0
MAP3K10 MAP3K10 Q02779 Mitogen-activated protein kinase kinase kinase 10 chr19 GO:0043406 Not Cancer Driver No 112 0.117 589 62 0.105 0
MAP3K11 MAP3K11 Q16584 Mitogen-activated protein kinase kinase kinase 11 chr11 GO:0043406 Not Cancer Driver No 97 0.115 466 54 0.116 0
MAP3K12_ENST00000267079 MAP3K12 Q12852 Mitogen-activated protein kinase kinase kinase 12 chr12 GO:0043406 Not Cancer Driver No 120 0.14 481 64 0.133 0
MAP3K13_ENST00000424227 MAP3K13 O43283 Mitogen-activated protein kinase kinase kinase 13 chr3 GO:0043406 Census Yes 157 0.163 593 91 0.153 0
MAP3K4 MAP3K4 Q9Y6R4 Mitogen-activated protein kinase kinase kinase 4 chr6 GO:0043406 Not Cancer Driver No 261 0.162 520 86 0.165 0
MAP3K5 MAP3K5 Q99683 Mitogen-activated protein kinase kinase kinase 5 chr6 GO:0043406 Not Cancer Driver No 197 0.143 242 29 0.12 0
MAP3K7 MAP3K7 O43318 Mitogen-activated protein kinase kinase kinase 7 chr6 GO:0043406 Not Cancer Driver No 104 0.172 333 66 0.198 6
MAP4K2 MAP4K2 Q12851 Mitogen-activated protein kinase kinase kinase kinase 2 chr11 GO:0043406 Not Cancer Driver No 78 0.095 243 23 0.095 0
MIF MIF P14174 Macrophage migration inhibitory factor chr22 GO:0043406 Not Cancer Driver No 4 0.035 0 0 0.0 0
MST1R MST1R Q04912 Macrophage-stimulating protein receptor chr3 GO:0043406 Not Cancer Driver No 178 0.127 182 27 0.148 1
NEK10_ENST00000429845 NEK10 Q6ZWH5 Serine/threonine-protein kinase Nek10 chr3 GO:0043406 Not Cancer Driver No 213 0.182 281 60 0.214 0
NOD2 NOD2 Q9HC29 Nucleotide-binding oligomerization domain-containing protein 2 chr16 GO:0043406 Not Cancer Driver No 169 0.163 40 4 0.1 15
NOX4 NOX4 Q9NPH5 NADPH oxidase 4 chr11 GO:0043406 Not Cancer Driver No 123 0.213 0 0 0.0 0
NTF3_ENST00000331010 NTF3 P20783 Neurotrophin-3 chr12 GO:0043406 Not Cancer Driver No 52 0.202 99 21 0.212 0
NTRK3_ENST00000629765 NTRK3 Q16288 NT-3 growth factor receptor chr15 GO:0043406 Census, Compendium Yes 249 0.297 57 21 0.368 0
P2RX7 P2RX7 Q99572 P2X purinoceptor 7 chr12 GO:0043406 Not Cancer Driver No 51 0.086 14 2 0.143 0
PAK1_ENST00000356341 PAK1 Q13153 Serine/threonine-protein kinase PAK 1 chr11 GO:0043406 Not Cancer Driver No 57 0.105 299 30 0.1 2
PDCD10_ENST00000473645 PDCD10 Q9BUL8 Programmed cell death protein 10 chr3 GO:0043406 Not Cancer Driver No 32 0.151 25 4 0.16 0
PDE5A PDE5A O76074 cGMP-specific 3',5'-cyclic phosphodiesterase chr4 GO:0043406 Not Cancer Driver No 113 0.129 163 23 0.141 0
PDGFA PDGFA P04085 Platelet-derived growth factor subunit A chr7 GO:0043406 Not Cancer Driver No 31 0.147 75 10 0.133 0
PDGFB PDGFB P01127 Platelet-derived growth factor subunit B chr22 GO:0043406 Census Yes 37 0.154 99 22 0.222 2
PDGFC PDGFC Q9NRA1 Platelet-derived growth factor C chr4 GO:0043406 Not Cancer Driver No 86 0.249 53 12 0.226 0
PDGFD PDGFD Q9GZP0 Platelet-derived growth factor D chr11 GO:0043406 Not Cancer Driver No 85 0.23 37 13 0.351 0
PDGFRB PDGFRB P09619 Platelet-derived growth factor receptor beta chr5 GO:0043406 Census, Compendium Yes 164 0.148 231 44 0.19 7
PIK3CG PIK3CG P48736 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform chr7 GO:0043406 Not Cancer Driver No 318 0.289 121 39 0.322 0
PIK3R5 PIK3R5 Q8WYR1 Phosphoinositide 3-kinase regulatory subunit 5 chr17 GO:0043406 Not Cancer Driver No 143 0.163 316 55 0.174 1
PIK3R6_ENST00000614407 PIK3R6 Q5UE93 Phosphoinositide 3-kinase regulatory subunit 6 chr17 GO:0043406 Not Cancer Driver No 100 0.133 156 26 0.167 0
PLA2G1B PLA2G1B P04054 Phospholipase A2 chr12 GO:0043406 Not Cancer Driver No 17 0.115 0 0 0.0 0
PSEN1 PSEN1 P49768 Presenilin-1 chr14 GO:0043406 Not Cancer Driver No 61 0.131 134 21 0.157 96
PTK2B_ENST00000346049 PTK2B Q14289 Protein-tyrosine kinase 2-beta chr8 GO:0043406 Not Cancer Driver No 161 0.16 261 37 0.142 0
PTPN1 PTPN1 P18031 Tyrosine-protein phosphatase non-receptor type 1 chr20 GO:0043406 Not Cancer Driver No 49 0.113 140 25 0.179 0
PTPRC PTPRC P08575 Receptor-type tyrosine-protein phosphatase C chr1 GO:0043406 Census, Compendium Yes 315 0.241 462 107 0.232 0
RASGRP1 RASGRP1 O95267 RAS guanyl-releasing protein 1 chr15 GO:0043406 Not Cancer Driver No 96 0.12 191 12 0.063 1
ROBO1 ROBO1 Q9Y6N7 Roundabout homolog 1 chr3 GO:0043406 Not Cancer Driver No 353 0.214 1122 234 0.209 0
ROR2 ROR2 Q01974 Tyrosine-protein kinase transmembrane receptor ROR2 chr9 GO:0043406 Not Cancer Driver No 203 0.215 299 71 0.237 5
RPS3_ENST00000527446 RPS3 P23396 40S ribosomal protein S3 chr11 GO:0043406 Not Cancer Driver No 22 0.091 48 4 0.083 0
S100A12 S100A12 P80511 Protein S100-A12 chr1 GO:0043406 Not Cancer Driver No 18 0.196 1 0 0.0 0
SASH1 SASH1 O94885 SAM and SH3 domain-containing protein 1 chr6 GO:0043406 Not Cancer Driver No 174 0.14 1071 153 0.143 7
SRC_ENST00000358208 SRC P12931 Proto-oncogene tyrosine-protein kinase Src chr20 GO:0043406 Census Yes 53 0.099 130 11 0.085 1
SYK_ENST00000375746 SYK P43405 Tyrosine-protein kinase SYK chr9 GO:0043406 Census Yes 96 0.151 131 27 0.206 5
TAB1 TAB1 Q15750 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 chr22 GO:0043406 Not Cancer Driver No 81 0.161 232 34 0.147 0
TAOK3 TAOK3 Q9H2K8 Serine/threonine-protein kinase TAO3 chr12 GO:0043406 Not Cancer Driver No 123 0.137 494 64 0.13 0
TDGF1 TDGF1 P13385 Teratocarcinoma-derived growth factor 1 chr3 GO:0043406 Not Cancer Driver No 39 0.207 25 2 0.08 0
TENM1_ENST00000371130 TENM1 Q9UKZ4 Teneurin-1 chrX GO:0043406 Not Cancer Driver No 728 0.267 482 164 0.34 0
TGFA_ENST00000295400 TGFA P01135 Protransforming growth factor alpha chr2 GO:0043406 Not Cancer Driver No 20 0.125 0 0 0.0 0
TGFB1 TGFB1 P01137 Transforming growth factor beta-1 proprotein chr19 GO:0043406 Not Cancer Driver No 41 0.105 41 4 0.098 10
THBS1 THBS1 P07996 Thrombospondin-1 chr15 GO:0043406 Not Cancer Driver No 188 0.161 320 58 0.181 0
TLR4_ENST00000355622 TLR4 O00206 Toll-like receptor 4 chr9 GO:0043406 Not Cancer Driver No 292 0.348 0 0 0.0 0
TLR6 TLR6 Q9Y2C9 Toll-like receptor 6 chr4 GO:0043406 Not Cancer Driver No 99 0.124 1 0 0.0 0
TLR9 TLR9 Q9NR96 Toll-like receptor 9 chr3 GO:0043406 Not Cancer Driver No 141 0.137 35 3 0.086 0
TNF TNF P01375 Tumor necrosis factor chr6 GO:0043406 Not Cancer Driver No 24 0.103 45 3 0.067 0
TNFRSF11A TNFRSF11A Q9Y6Q6 Tumor necrosis factor receptor superfamily member 11A chr18 GO:0043406 Not Cancer Driver No 70 0.114 285 33 0.116 0
TNFSF11 TNFSF11 O14788 Tumor necrosis factor ligand superfamily member 11 chr13 GO:0043406 Not Cancer Driver No 52 0.164 56 1 0.018 1
TPD52L1_ENST00000534000 TPD52L1 Q16890 Tumor protein D53 chr6 GO:0043406 Not Cancer Driver No 46 0.225 170 38 0.224 0
TRAF2 TRAF2 Q12933 TNF receptor-associated factor 2 chr9 GO:0043406 Not Cancer Driver No 63 0.126 4 1 0.25 0
TRAF6_ENST00000348124 TRAF6 Q9Y4K3 TNF receptor-associated factor 6 chr11 GO:0043406 Not Cancer Driver No 67 0.128 62 7 0.113 0
VEGFA_ENST00000523873 VEGFA P15692 Vascular endothelial growth factor A chr6 GO:0043406 Not Cancer Driver No 27 0.116 41 7 0.171 0
WNT5A_ENST00000474267 WNT5A P41221 Protein Wnt-5a chr3 GO:0043406 Not Cancer Driver No 66 0.174 0 0 0.0 2