Total number of protein in "GO:0042558" GO term: 34
| Identifier | UniProt Gene | UniProt Accession | UniProt Name | Chromosome | GO term | Database | Cancer Driver | Number of missense mutations | Missense mutation per residues | Number of disordered residues | Number of mutations in disordered regions | Disordered missense mutations per residues | Number of OMIM mutation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AASDHPPT | AASDHPPT | Q9NRN7 | L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | chr11 | GO:0042558 | Not Cancer Driver | No | 52 | 0.168 | 27 | 2 | 0.074 | 0 |
| ALDH1L1_ENST00000393434 | ALDH1L1 | O75891 | Cytosolic 10-formyltetrahydrofolate dehydrogenase | chr3 | GO:0042558 | Not Cancer Driver | No | 159 | 0.176 | 87 | 19 | 0.218 | 0 |
| ALDH1L2 | ALDH1L2 | Q3SY69 | Mitochondrial 10-formyltetrahydrofolate dehydrogenase | chr12 | GO:0042558 | Not Cancer Driver | No | 108 | 0.117 | 81 | 12 | 0.148 | 0 |
| ATIC | ATIC | P31939 | Bifunctional purine biosynthesis protein ATIC | chr2 | GO:0042558 | Census | Yes | 74 | 0.125 | 25 | 1 | 0.04 | 1 |
| DHFR | DHFR | P00374 | Dihydrofolate reductase | chr5 | GO:0042558 | Not Cancer Driver | No | 16 | 0.086 | 12 | 2 | 0.167 | 2 |
| DHFR2_ENST00000314636 | DHFR2 | Q86XF0 | Dihydrofolate reductase 2, mitochondrial | chr3 | GO:0042558 | Not Cancer Driver | No | 25 | 0.134 | 20 | 0 | 0.0 | 0 |
| FOLR1_ENST00000393681 | FOLR1 | P15328 | Folate receptor alpha | chr11 | GO:0042558 | Not Cancer Driver | No | 41 | 0.16 | 13 | 3 | 0.231 | 0 |
| FPGS | FPGS | Q05932 | Folylpolyglutamate synthase, mitochondrial | chr9 | GO:0042558 | Not Cancer Driver | No | 68 | 0.116 | 141 | 18 | 0.128 | 0 |
| FTCD_ENST00000291670 | FTCD | O95954 | Formimidoyltransferase-cyclodeaminase | chr21 | GO:0042558 | Not Cancer Driver | No | 86 | 0.159 | 44 | 36 | 0.818 | 2 |
| GART_ENST00000381815 | GART | P22102 | Trifunctional purine biosynthetic protein adenosine-3 | chr21 | GO:0042558 | Not Cancer Driver | No | 96 | 0.095 | 50 | 6 | 0.12 | 0 |
| GCH1_ENST00000622544 | GCH1 | P30793 | GTP cyclohydrolase 1 | chr14 | GO:0042558 | Not Cancer Driver | No | 20 | 0.08 | 99 | 5 | 0.051 | 38 |
| GGH | GGH | Q92820 | Gamma-glutamyl hydrolase | chr8 | GO:0042558 | Not Cancer Driver | No | 46 | 0.145 | 5 | 0 | 0.0 | 0 |
| MTHFD1 | MTHFD1 | P11586 | C-1-tetrahydrofolate synthase, cytoplasmic | chr14 | GO:0042558 | Not Cancer Driver | No | 103 | 0.11 | 129 | 11 | 0.085 | 6 |
| MTHFD1L_ENST00000367321 | MTHFD1L | Q6UB35 | Monofunctional C1-tetrahydrofolate synthase, mitochondrial | chr6 | GO:0042558 | Not Cancer Driver | No | 117 | 0.12 | 139 | 11 | 0.079 | 0 |
| MTHFD2 | MTHFD2 | P13995 | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial | chr2 | GO:0042558 | Not Cancer Driver | No | 39 | 0.111 | 39 | 3 | 0.077 | 0 |
| MTHFD2L | MTHFD2L | Q9H903 | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial | chr4 | GO:0042558 | Not Cancer Driver | No | 45 | 0.13 | 59 | 6 | 0.102 | 0 |
| MTHFR_ENST00000376590 | MTHFR | P42898 | Methylenetetrahydrofolate reductase | chr1 | GO:0042558 | Not Cancer Driver | No | 95 | 0.145 | 125 | 22 | 0.176 | 53 |
| MTHFS | MTHFS | P49914 | 5-formyltetrahydrofolate cyclo-ligase | chr15 | GO:0042558 | Not Cancer Driver | No | 18 | 0.089 | 36 | 6 | 0.167 | 2 |
| MTR | MTR | Q99707 | Methionine synthase | chr1 | GO:0042558 | Not Cancer Driver | No | 151 | 0.119 | 104 | 17 | 0.163 | 2 |
| MTRR_ENST00000440940 | MTRR | Q9UBK8 | Methionine synthase reductase | chr5 | GO:0042558 | Not Cancer Driver | No | 101 | 0.145 | 84 | 13 | 0.155 | 5 |
| PCBD1 | PCBD1 | P61457 | Pterin-4-alpha-carbinolamine dehydratase | chr10 | GO:0042558 | Not Cancer Driver | No | 8 | 0.077 | 7 | 0 | 0.0 | 3 |
| PCBD2_ENST00000254908 | PCBD2 | Q9H0N5 | Pterin-4-alpha-carbinolamine dehydratase 2 | chr5 | GO:0042558 | Not Cancer Driver | No | 6 | 0.046 | 3 | 0 | 0.0 | 0 |
| PIPOX | PIPOX | Q9P0Z9 | Peroxisomal sarcosine oxidase | chr17 | GO:0042558 | Not Cancer Driver | No | 52 | 0.133 | 21 | 3 | 0.143 | 0 |
| PM20D2 | PM20D2 | Q8IYS1 | Xaa-Arg dipeptidase | chr6 | GO:0042558 | Not Cancer Driver | No | 39 | 0.089 | 79 | 7 | 0.089 | 0 |
| PRKG2 | PRKG2 | Q13237 | cGMP-dependent protein kinase 2 | chr4 | GO:0042558 | Not Cancer Driver | No | 138 | 0.181 | 217 | 48 | 0.221 | 0 |
| PTS | PTS | Q03393 | 6-pyruvoyl tetrahydrobiopterin synthase | chr11 | GO:0042558 | Not Cancer Driver | No | 9 | 0.062 | 22 | 1 | 0.045 | 24 |
| QDPR | QDPR | P09417 | Dihydropteridine reductase | chr4 | GO:0042558 | Not Cancer Driver | No | 41 | 0.168 | 25 | 3 | 0.12 | 16 |
| SHMT1 | SHMT1 | P34896 | Serine hydroxymethyltransferase, cytosolic | chr17 | GO:0042558 | Not Cancer Driver | No | 51 | 0.106 | 32 | 7 | 0.219 | 0 |
| SHMT2 | SHMT2 | P34897 | Serine hydroxymethyltransferase, mitochondrial | chr12 | GO:0042558 | Not Cancer Driver | No | 57 | 0.113 | 58 | 5 | 0.086 | 1 |
| SLC19A1 | SLC19A1 | P41440 | Reduced folate transporter | chr21 | GO:0042558 | Not Cancer Driver | No | 77 | 0.13 | 144 | 7 | 0.049 | 0 |
| SLC25A32 | SLC25A32 | Q9H2D1 | Mitochondrial folate transporter/carrier | chr8 | GO:0042558 | Not Cancer Driver | No | 45 | 0.143 | 4 | 0 | 0.0 | 1 |
| SLC46A1 | SLC46A1 | Q96NT5 | Proton-coupled folate transporter | chr17 | GO:0042558 | Not Cancer Driver | No | 37 | 0.081 | 31 | 0 | 0.0 | 13 |
| SPR | SPR | P35270 | Sepiapterin reductase | chr2 | GO:0042558 | Not Cancer Driver | No | 23 | 0.088 | 19 | 4 | 0.211 | 2 |
| TYMS | TYMS | P04818 | Thymidylate synthase | chr18 | GO:0042558 | Not Cancer Driver | No | 22 | 0.07 | 41 | 0 | 0.0 | 0 |