Total number of protein in "GO:0035861" GO term: 73
| Identifier | UniProt Gene | UniProt Accession | UniProt Name | Chromosome | GO term | Database | Cancer Driver | Number of missense mutations | Missense mutation per residues | Number of disordered residues | Number of mutations in disordered regions | Disordered missense mutations per residues | Number of OMIM mutation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ACTR2_ENST00000260641 | ACTR2 | P61160 | Actin-related protein 2 | chr2 | GO:0035861 | Not Cancer Driver | No | 51 | 0.129 | 6 | 2 | 0.333 | 0 |
| ACTR3 | ACTR3 | P61158 | Actin-related protein 3 | chr2 | GO:0035861 | Not Cancer Driver | No | 32 | 0.077 | 16 | 2 | 0.125 | 0 |
| APLF | APLF | Q8IW19 | Aprataxin and PNK-like factor | chr2 | GO:0035861 | Not Cancer Driver | No | 64 | 0.125 | 407 | 57 | 0.14 | 0 |
| ARPC1A | ARPC1A | Q92747 | Actin-related protein 2/3 complex subunit 1A | chr7 | GO:0035861 | Not Cancer Driver | No | 48 | 0.13 | 27 | 7 | 0.259 | 0 |
| ARPC2_ENST00000315717 | ARPC2 | O15144 | Actin-related protein 2/3 complex subunit 2 | chr2 | GO:0035861 | Not Cancer Driver | No | 40 | 0.133 | 49 | 8 | 0.163 | 0 |
| ARPC3 | ARPC3 | O15145 | Actin-related protein 2/3 complex subunit 3 | chr12 | GO:0035861 | Not Cancer Driver | No | 17 | 0.096 | 26 | 6 | 0.231 | 0 |
| ARPC4_ENST00000397261 | ARPC4 | P59998 | Actin-related protein 2/3 complex subunit 4 | chr3 | GO:0035861 | Not Cancer Driver | No | 11 | 0.065 | 3 | 0 | 0.0 | 0 |
| ARPC5_ENST00000359856 | ARPC5 | O15511 | Actin-related protein 2/3 complex subunit 5 | chr1 | GO:0035861 | Not Cancer Driver | No | 15 | 0.099 | 66 | 7 | 0.106 | 0 |
| ATF2 | ATF2 | P15336 | Cyclic AMP-dependent transcription factor ATF-2 | chr2 | GO:0035861 | Not Cancer Driver | No | 65 | 0.129 | 451 | 58 | 0.129 | 0 |
| CGAS | CGAS | Q8N884 | Cyclic GMP-AMP synthase | chr6 | GO:0035861 | Not Cancer Driver | No | 50 | 0.096 | 173 | 7 | 0.04 | 0 |
| CNTD1 | CNTD1 | Q8N815 | Cyclin N-terminal domain-containing protein 1 | chr17 | GO:0035861 | Not Cancer Driver | No | 32 | 0.097 | 30 | 4 | 0.133 | 0 |
| CYREN | CYREN | Q9BWK5 | Cell cycle regulator of non-homologous end joining | chr7 | GO:0035861 | Not Cancer Driver | No | 24 | 0.153 | 128 | 19 | 0.148 | 0 |
| DDB1 | DDB1 | Q16531 | DNA damage-binding protein 1 | chr11 | GO:0035861 | Not Cancer Driver | No | 126 | 0.111 | 50 | 8 | 0.16 | 4 |
| ESCO2 | ESCO2 | Q56NI9 | N-acetyltransferase ESCO2 | chr8 | GO:0035861 | Not Cancer Driver | No | 67 | 0.111 | 292 | 32 | 0.11 | 1 |
| H2AFX | H2AX | P16104 | Histone H2AX | chr11 | GO:0035861 | Not Cancer Driver | No | 20 | 0.14 | 68 | 10 | 0.147 | 0 |
| HELB | HELB | Q8NG08 | DNA helicase B | chr12 | GO:0035861 | Not Cancer Driver | No | 140 | 0.129 | 300 | 38 | 0.127 | 0 |
| HUS1 | HUS1 | O60921 | Checkpoint protein HUS1 | chr7 | GO:0035861 | Not Cancer Driver | No | 25 | 0.089 | 17 | 2 | 0.118 | 0 |
| HUS1B | HUS1B | Q8NHY5 | Checkpoint protein HUS1B | chr6 | GO:0035861 | Not Cancer Driver | No | 50 | 0.18 | 10 | 1 | 0.1 | 0 |
| IFFO1_ENST00000396840 | IFFO1 | Q0D2I5 | Non-homologous end joining factor IFFO1 | chr12 | GO:0035861 | Not Cancer Driver | No | 59 | 0.106 | 363 | 33 | 0.091 | 0 |
| INIP | INIP | Q9NRY2 | SOSS complex subunit C | chr9 | GO:0035861 | Not Cancer Driver | No | 25 | 0.24 | 79 | 16 | 0.203 | 0 |
| INTS3_ENST00000435409 | INTS3 | Q68E01 | Integrator complex subunit 3 | chr1 | GO:0035861 | Not Cancer Driver | No | 125 | 0.12 | 213 | 25 | 0.117 | 0 |
| KDM4D_ENST00000610872 | KDM4D | Q6B0I6 | Lysine-specific demethylase 4D | chr11 | GO:0035861 | Not Cancer Driver | No | 78 | 0.149 | 215 | 33 | 0.153 | 0 |
| LMNA | LMNA | P02545 | Prelamin-A/C | chr1 | GO:0035861 | Census | Yes | 68 | 0.102 | 544 | 49 | 0.09 | 131 |
| MAD2L2 | MAD2L2 | Q9UI95 | Mitotic spindle assembly checkpoint protein MAD2B | chr1 | GO:0035861 | Not Cancer Driver | No | 22 | 0.104 | 0 | 0 | 0.0 | 1 |
| MRE11 | MRE11 | P49959 | Double-strand break repair protein MRE11 | chr11 | GO:0035861 | Not Cancer Driver | No | 84 | 0.119 | 292 | 35 | 0.12 | 1 |
| NABP1 | NABP1 | Q96AH0 | SOSS complex subunit B2 | chr2 | GO:0035861 | Not Cancer Driver | No | 25 | 0.123 | 102 | 11 | 0.108 | 0 |
| NABP2_ENST00000341463 | NABP2 | Q9BQ15 | SOSS complex subunit B1 | chr12 | GO:0035861 | Not Cancer Driver | No | 25 | 0.118 | 125 | 17 | 0.136 | 0 |
| NBN | NBN | O60934 | Nibrin | chr8 | GO:0035861 | Census | Yes | 90 | 0.119 | 417 | 54 | 0.129 | 1 |
| NHEJ1 | NHEJ1 | Q9H9Q4 | Non-homologous end-joining factor 1 | chr2 | GO:0035861 | Not Cancer Driver | No | 35 | 0.117 | 83 | 8 | 0.096 | 2 |
| PARP1 | PARP1 | P09874 | Poly [ADP-ribose] polymerase 1 | chr1 | GO:0035861 | Not Cancer Driver | No | 119 | 0.117 | 320 | 34 | 0.106 | 0 |
| PARP3_ENST00000431474 | PARP3 | Q9Y6F1 | Protein mono-ADP-ribosyltransferase PARP3 | chr3 | GO:0035861 | Not Cancer Driver | No | 70 | 0.131 | 269 | 38 | 0.141 | 0 |
| PAXX | PAXX | Q9BUH6 | Protein PAXX | chr9 | GO:0035861 | Not Cancer Driver | No | 22 | 0.108 | 121 | 17 | 0.14 | 0 |
| PHF1 | PHF1 | O43189 | PHD finger protein 1 | chr6 | GO:0035861 | Not Cancer Driver | No | 62 | 0.109 | 277 | 29 | 0.105 | 0 |
| PNKP | PNKP | Q96T60 | Bifunctional polynucleotide phosphatase/kinase | chr19 | GO:0035861 | Not Cancer Driver | No | 53 | 0.102 | 177 | 23 | 0.13 | 4 |
| POLH | POLH | Q9Y253 | DNA polymerase eta | chr6 | GO:0035861 | Not Cancer Driver | No | 72 | 0.101 | 291 | 20 | 0.069 | 10 |
| POLL_ENST00000370169 | POLL | Q9UGP5 | DNA polymerase lambda | chr10 | GO:0035861 | Not Cancer Driver | No | 69 | 0.12 | 215 | 16 | 0.074 | 0 |
| PRPF19 | PRPF19 | Q9UMS4 | Pre-mRNA-processing factor 19 | chr11 | GO:0035861 | Not Cancer Driver | No | 71 | 0.141 | 109 | 16 | 0.147 | 0 |
| RAD18 | RAD18 | Q9NS91 | E3 ubiquitin-protein ligase RAD18 | chr3 | GO:0035861 | Not Cancer Driver | No | 59 | 0.119 | 328 | 43 | 0.131 | 0 |
| RAD50 | RAD50 | Q92878 | DNA repair protein RAD50 | chr5 | GO:0035861 | Not Cancer Driver | No | 157 | 0.12 | 730 | 84 | 0.115 | 0 |
| RAD51_ENST00000267868 | RAD51 | Q06609 | DNA repair protein RAD51 homolog 1 | chr15 | GO:0035861 | Not Cancer Driver | No | 42 | 0.124 | 47 | 5 | 0.106 | 3 |
| RBBP8_ENST00000327155 | RBBP8 | Q99708 | DNA endonuclease RBBP8 | chr18 | GO:0035861 | Not Cancer Driver | No | 99 | 0.11 | 750 | 76 | 0.101 | 1 |
| RFWD3 | RFWD3 | Q6PCD5 | E3 ubiquitin-protein ligase RFWD3 | chr16 | GO:0035861 | Census | Yes | 68 | 0.088 | 318 | 30 | 0.094 | 1 |
| RIF1 | RIF1 | Q5UIP0 | Telomere-associated protein RIF1 | chr2 | GO:0035861 | Not Cancer Driver | No | 287 | 0.116 | 1355 | 164 | 0.121 | 0 |
| RNF138 | RNF138 | Q8WVD3 | E3 ubiquitin-protein ligase RNF138 | chr18 | GO:0035861 | Not Cancer Driver | No | 44 | 0.18 | 34 | 6 | 0.176 | 0 |
| RNF168 | RNF168 | Q8IYW5 | E3 ubiquitin-protein ligase RNF168 | chr3 | GO:0035861 | Not Cancer Driver | No | 77 | 0.135 | 471 | 66 | 0.14 | 0 |
| RNF169 | RNF169 | Q8NCN4 | E3 ubiquitin-protein ligase RNF169 | chr11 | GO:0035861 | Not Cancer Driver | No | 52 | 0.073 | 637 | 46 | 0.072 | 0 |
| RNF8 | RNF8 | O76064 | E3 ubiquitin-protein ligase RNF8 | chr6 | GO:0035861 | Not Cancer Driver | No | 56 | 0.115 | 226 | 29 | 0.128 | 0 |
| RPA2_ENST00000373912 | RPA2 | P15927 | Replication protein A 32 kDa subunit | chr1 | GO:0035861 | Not Cancer Driver | No | 28 | 0.104 | 114 | 16 | 0.14 | 0 |
| RPA3 | RPA3 | P35244 | Replication protein A 14 kDa subunit | chr7 | GO:0035861 | Not Cancer Driver | No | 13 | 0.107 | 4 | 1 | 0.25 | 0 |
| RPA4 | RPA4 | Q13156 | Replication protein A 30 kDa subunit | chrX | GO:0035861 | Not Cancer Driver | No | 66 | 0.253 | 58 | 15 | 0.259 | 0 |
| SAMHD1 | SAMHD1 | Q9Y3Z3 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | chr20 | GO:0035861 | Not Cancer Driver | No | 104 | 0.166 | 91 | 14 | 0.154 | 13 |
| SETMAR | SETMAR | Q53H47 | Histone-lysine N-methyltransferase SETMAR | chr3 | GO:0035861 | Not Cancer Driver | No | 62 | 0.091 | 154 | 12 | 0.078 | 0 |
| SHLD1 | SHLD1 | Q8IYI0 | Shieldin complex subunit 1 | chr20 | GO:0035861 | Not Cancer Driver | No | 30 | 0.146 | 116 | 20 | 0.172 | 0 |
| SHLD2_ENST00000298784 | SHLD2 | Q86V20 | Shieldin complex subunit 2 | chr10 | GO:0035861 | Not Cancer Driver | No | 84 | 0.101 | 157 | 14 | 0.089 | 0 |
| SHLD3 | SHLD3 | Q6ZNX1 | Shieldin complex subunit 3 | chr5 | GO:0035861 | Not Cancer Driver | No | 3 | 0.012 | 81 | 1 | 0.012 | 0 |
| SIRT7 | SIRT7 | Q9NRC8 | NAD-dependent protein deacetylase sirtuin-7 | chr17 | GO:0035861 | Not Cancer Driver | No | 48 | 0.12 | 163 | 15 | 0.092 | 0 |
| SLF1 | SLF1 | Q9BQI6 | SMC5-SMC6 complex localization factor protein 1 | chr5 | GO:0035861 | Not Cancer Driver | No | 104 | 0.098 | 167 | 12 | 0.072 | 0 |
| SLF2_ENST00000238961 | SLF2 | Q8IX21 | SMC5-SMC6 complex localization factor protein 2 | chr10 | GO:0035861 | Not Cancer Driver | No | 112 | 0.095 | 725 | 76 | 0.105 | 0 |
| SMARCAD1_ENST00000354268 | SMARCAD1 | Q9H4L7 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 | chr4 | GO:0035861 | Not Cancer Driver | No | 129 | 0.126 | 388 | 50 | 0.129 | 0 |
| SMARCAL1 | SMARCAL1 | Q9NZC9 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 | chr2 | GO:0035861 | Not Cancer Driver | No | 128 | 0.134 | 335 | 49 | 0.146 | 11 |
| SMC5 | SMC5 | Q8IY18 | Structural maintenance of chromosomes protein 5 | chr9 | GO:0035861 | Not Cancer Driver | No | 126 | 0.114 | 378 | 43 | 0.114 | 0 |
| SMC6_ENST00000351948 | SMC6 | Q96SB8 | Structural maintenance of chromosomes protein 6 | chr2 | GO:0035861 | Not Cancer Driver | No | 128 | 0.117 | 458 | 57 | 0.124 | 0 |
| SMCHD1 | SMCHD1 | A6NHR9 | Structural maintenance of chromosomes flexible hinge domain-containing protein 1 | chr18 | GO:0035861 | Not Cancer Driver | No | 240 | 0.12 | 342 | 45 | 0.132 | 45 |
| TIMELESS | TIMELESS | Q9UNS1 | Protein timeless homolog | chr12 | GO:0035861 | Not Cancer Driver | No | 154 | 0.127 | 367 | 51 | 0.139 | 0 |
| TP53BP1_ENST00000263801 | TP53BP1 | Q12888 | TP53-binding protein 1 | chr15 | GO:0035861 | Not Cancer Driver | No | 227 | 0.115 | 1632 | 190 | 0.116 | 0 |
| TP53_ENST00000445888 | TP53 | P04637 | Cellular tumor antigen p53 | chr17 | GO:0035861 | Census, Compendium | Yes | 2891 | 7.356 | 282 | 1466 | 5.199 | 83 |
| UFL1 | UFL1 | O94874 | E3 UFM1-protein ligase 1 | chr6 | GO:0035861 | Not Cancer Driver | No | 109 | 0.137 | 141 | 24 | 0.17 | 0 |
| VCP | VCP | P55072 | Transitional endoplasmic reticulum ATPase | chr9 | GO:0035861 | Not Cancer Driver | No | 88 | 0.109 | 186 | 16 | 0.086 | 16 |
| WAS | WAS | P42768 | Wiskott-Aldrich syndrome protein | chrX | GO:0035861 | Census, Compendium | Yes | 75 | 0.149 | 400 | 55 | 0.138 | 30 |
| WDR70 | WDR70 | Q9NW82 | WD repeat-containing protein 70 | chr5 | GO:0035861 | Not Cancer Driver | No | 97 | 0.148 | 363 | 57 | 0.157 | 0 |
| WRAP53 | WRAP53 | Q9BUR4 | Telomerase Cajal body protein 1 | chr17 | GO:0035861 | Not Cancer Driver | No | 66 | 0.12 | 232 | 29 | 0.125 | 4 |
| XRCC4 | XRCC4 | Q13426 | DNA repair protein XRCC4 | chr5 | GO:0035861 | Not Cancer Driver | No | 47 | 0.14 | 171 | 31 | 0.181 | 3 |
| ZBTB7A_ENST00000601588 | ZBTB7A | O95365 | Zinc finger and BTB domain-containing protein 7A | chr19 | GO:0035861 | Not Cancer Driver | No | 60 | 0.103 | 285 | 30 | 0.105 | 0 |