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Total number of protein in "GO:0033554" GO term:  554

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
ABCB10 ABCB10 Q9NRK6 ATP-binding cassette sub-family B member 10, mitochondrial chr1 GO:0033554 Not Cancer Driver No 103 0.14 47 0 0.0 0
ABL1_ENST00000318560 ABL1 P00519 Tyrosine-protein kinase ABL1 chr9 GO:0033554 Census, Compendium Yes 139 0.123 604 73 0.121 2
ACD_ENST00000620761 ACD Q96AP0 Adrenocortical dysplasia protein homolog chr16 GO:0033554 Not Cancer Driver No 49 0.107 256 34 0.133 1
ACER2 ACER2 Q5QJU3 Alkaline ceramidase 2 chr9 GO:0033554 Not Cancer Driver No 27 0.098 0 0 0.0 0
ACTR5 ACTR5 Q9H9F9 Actin-related protein 5 chr20 GO:0033554 Not Cancer Driver No 63 0.104 163 23 0.141 0
ADM ADM P35318 Pro-adrenomedullin chr11 GO:0033554 Not Cancer Driver No 20 0.108 113 13 0.115 0
ADPRHL2 ADPRS Q9NX46 ADP-ribosylhydrolase ARH3 chr1 GO:0033554 Not Cancer Driver No 32 0.088 49 4 0.082 1
AGAP3_ENST00000622464 AGAP3 Q96P47 Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 chr7 GO:0033554 Not Cancer Driver No 116 0.133 404 55 0.136 0
AIF1 AIF1 P55008 Allograft inflammatory factor 1 chr6 GO:0033554 Not Cancer Driver No 14 0.095 61 6 0.098 0
AIFM1 AIFM1 O95831 Apoptosis-inducing factor 1, mitochondrial chrX GO:0033554 Not Cancer Driver No 88 0.144 166 22 0.133 11
AKR1B1 AKR1B1 P15121 Aldo-keto reductase family 1 member B1 chr7 GO:0033554 Not Cancer Driver No 52 0.165 19 1 0.053 0
AKR1C3 AKR1C3 P42330 Aldo-keto reductase family 1 member C3 chr10 GO:0033554 Not Cancer Driver No 49 0.152 11 1 0.091 0
AKT1_ENST00000349310 AKT1 P31749 RAC-alpha serine/threonine-protein kinase chr14 GO:0033554 Census, Compendium Yes 108 0.225 158 24 0.152 4
AMBRA1_ENST00000458649 AMBRA1 Q9C0C7 Activating molecule in BECN1-regulated autophagy protein 1 chr11 GO:0033554 Not Cancer Driver No 173 0.133 788 103 0.131 0
ANKRD2 ANKRD2 Q9GZV1 Ankyrin repeat domain-containing protein 2 chr10 GO:0033554 Not Cancer Driver No 34 0.094 192 18 0.094 0
ANKZF1 ANKZF1 Q9H8Y5 Ankyrin repeat and zinc finger domain-containing protein 1 chr2 GO:0033554 Not Cancer Driver No 77 0.106 507 57 0.112 0
ANXA1_ENST00000257497 ANXA1 P04083 Annexin A1 chr9 GO:0033554 Not Cancer Driver No 59 0.171 61 12 0.197 0
AOC1_ENST00000467291 AOC1 P19801 Amiloride-sensitive amine oxidase [copper-containing] chr7 GO:0033554 Not Cancer Driver No 161 0.214 98 26 0.265 0
APAF1 APAF1 O14727 Apoptotic protease-activating factor 1 chr12 GO:0033554 Not Cancer Driver No 127 0.102 17 1 0.059 0
APEX1_ENST00000555414 APEX1 P27695 DNA-(apurinic or apyrimidinic site) endonuclease chr14 GO:0033554 Not Cancer Driver No 34 0.107 103 14 0.136 0
APLF APLF Q8IW19 Aprataxin and PNK-like factor chr2 GO:0033554 Not Cancer Driver No 64 0.125 407 57 0.14 0
APOA4 APOA4 P06727 Apolipoprotein A-IV chr11 GO:0033554 Not Cancer Driver No 77 0.194 298 65 0.218 0
APOD APOD P05090 Apolipoprotein D chr3 GO:0033554 Not Cancer Driver No 34 0.18 13 2 0.154 0
APTX_ENST00000379819 APTX Q7Z2E3 Aprataxin chr9 GO:0033554 Not Cancer Driver No 36 0.101 101 6 0.059 9
AQP1 AQP1 P29972 Aquaporin-1 chr7 GO:0033554 Not Cancer Driver No 39 0.145 4 1 0.25 0
AQP2 AQP2 P41181 Aquaporin-2 chr12 GO:0033554 Not Cancer Driver No 52 0.192 31 3 0.097 28
AQP5 AQP5 P55064 Aquaporin-5 chr12 GO:0033554 Not Cancer Driver No 31 0.117 21 2 0.095 5
ARG1_ENST00000368087 ARG1 P05089 Arginase-1 chr6 GO:0033554 Not Cancer Driver No 41 0.127 83 12 0.145 9
ARHGEF10L ARHGEF10L Q9HCE6 Rho guanine nucleotide exchange factor 10-like protein chr1 GO:0033554 Census, Compendium Yes 155 0.121 431 47 0.109 0
ARHGEF2 ARHGEF2 Q92974 Rho guanine nucleotide exchange factor 2 chr1 GO:0033554 Not Cancer Driver No 146 0.148 450 70 0.156 0
ARNT ARNT P27540 Aryl hydrocarbon receptor nuclear translocator chr1 GO:0033554 Census Yes 77 0.098 511 56 0.11 0
ARNTL ARNTL O00327 Aryl hydrocarbon receptor nuclear translocator-like protein 1 chr11 GO:0033554 Not Cancer Driver No 71 0.113 332 40 0.12 0
ASNS_ENST00000394308 ASNS P08243 Asparagine synthetase [glutamine-hydrolyzing] chr7 GO:0033554 Not Cancer Driver No 81 0.144 11 0 0.0 3
ASS1_ENST00000352480 ASS1 P00966 Argininosuccinate synthase chr9 GO:0033554 Not Cancer Driver No 65 0.158 63 8 0.127 86
ATF2 ATF2 P15336 Cyclic AMP-dependent transcription factor ATF-2 chr2 GO:0033554 Not Cancer Driver No 65 0.129 451 58 0.129 0
ATF3_ENST00000366987 ATF3 P18847 Cyclic AMP-dependent transcription factor ATF-3 chr1 GO:0033554 Not Cancer Driver No 23 0.127 118 14 0.119 0
ATF4_ENST00000404241 ATF4 P18848 Cyclic AMP-dependent transcription factor ATF-4 chr22 GO:0033554 Not Cancer Driver No 53 0.151 259 38 0.147 0
ATF6 ATF6 P18850 Cyclic AMP-dependent transcription factor ATF-6 alpha chr1 GO:0033554 Not Cancer Driver No 88 0.131 468 59 0.126 2
ATF6B ATF6B Q99941 Cyclic AMP-dependent transcription factor ATF-6 beta chr6 GO:0033554 Not Cancer Driver No 70 0.1 557 59 0.106 0
ATG10 ATG10 Q9H0Y0 Ubiquitin-like-conjugating enzyme ATG10 chr5 GO:0033554 Not Cancer Driver No 22 0.1 9 1 0.111 0
ATG14 ATG14 Q6ZNE5 Beclin 1-associated autophagy-related key regulator chr14 GO:0033554 Not Cancer Driver No 48 0.098 209 24 0.115 0
ATG5_ENST00000343245 ATG5 Q9H1Y0 Autophagy protein 5 chr6 GO:0033554 Not Cancer Driver No 40 0.145 25 6 0.24 1
ATG7 ATG7 O95352 Ubiquitin-like modifier-activating enzyme ATG7 chr3 GO:0033554 Compendium Yes 77 0.11 53 8 0.151 6
ATM_ENST00000452508 ATM Q13315 Serine-protein kinase ATM chr11 GO:0033554 Census, Compendium Yes 469 0.153 225 39 0.173 41
ATP2A1 ATP2A1 O14983 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 chr16 GO:0033554 Not Cancer Driver No 157 0.157 80 11 0.138 1
ATP2A3_ENST00000397041 ATP2A3 Q93084 Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 chr17 GO:0033554 Not Cancer Driver No 130 0.13 147 16 0.109 0
ATP5IF1 ATP5IF1 Q9UII2 ATPase inhibitor, mitochondrial chr1 GO:0033554 Not Cancer Driver No 8 0.075 85 7 0.082 0
ATRX ATRX P46100 Transcriptional regulator ATRX chrX GO:0033554 Census, Compendium Yes 487 0.195 1672 301 0.18 33
AUP1 AUP1 Q9Y679 Lipid droplet-regulating VLDL assembly factor AUP1 chr2 GO:0033554 Not Cancer Driver No 41 0.1 122 13 0.107 0
AVPR1A AVPR1A P37288 Vasopressin V1a receptor chr12 GO:0033554 Not Cancer Driver No 105 0.251 68 25 0.368 0
AXL AXL P30530 Tyrosine-protein kinase receptor UFO chr19 GO:0033554 Not Cancer Driver No 168 0.188 341 64 0.188 0
BACH1_ENST00000286800 BACH1 O14867 Transcription regulator protein BACH1 chr21 GO:0033554 Not Cancer Driver No 105 0.143 328 39 0.119 0
BAG3 BAG3 O95817 BAG family molecular chaperone regulator 3 chr10 GO:0033554 Not Cancer Driver No 57 0.099 571 57 0.1 7
BAG6 BAG6 P46379 Large proline-rich protein BAG6 chr6 GO:0033554 Not Cancer Driver No 98 0.087 861 79 0.092 0
BAK1 BAK1 Q16611 Bcl-2 homologous antagonist/killer chr6 GO:0033554 Not Cancer Driver No 38 0.18 58 9 0.155 0
BATF BATF Q16520 Basic leucine zipper transcriptional factor ATF-like chr14 GO:0033554 Not Cancer Driver No 28 0.224 119 25 0.21 0
BAX_ENST00000345358 BAX Q07812 Apoptosis regulator BAX chr19 GO:0033554 Census Yes 30 0.156 39 2 0.051 0
BBC3 BBC3 Q96PG8 Bcl-2-binding component 3, isoforms 3/4 chr19 GO:0033554 Not Cancer Driver No 20 0.077 253 20 0.079 0
BCL2L11 BCL2L11 O43521 Bcl-2-like protein 11 chr2 GO:0033554 Not Cancer Driver No 42 0.212 130 17 0.131 0
BCL2_ENST00000333681 BCL2 P10415 Apoptosis regulator Bcl-2 chr18 GO:0033554 Census, Compendium Yes 24 0.1 72 5 0.069 0
BCL3 BCL3 P20749 B-cell lymphoma 3 protein chr19 GO:0033554 Census Yes 44 0.097 259 23 0.089 0
BCLAF1 BCLAF1 Q9NYF8 Bcl-2-associated transcription factor 1 chr6 GO:0033554 Census, Compendium Yes 421 0.458 899 408 0.454 0
BECN1_ENST00000590099 BECN1 Q14457 Beclin-1 chr17 GO:0033554 Not Cancer Driver No 45 0.1 190 19 0.1 0
BHLHA15 BHLHA15 Q7RTS1 Class A basic helix-loop-helix protein 15 chr7 GO:0033554 Not Cancer Driver No 12 0.063 183 12 0.066 0
BRCA2_ENST00000544455 BRCA2 P51587 Breast cancer type 2 susceptibility protein chr13 GO:0033554 Census, Compendium Yes 457 0.134 1542 225 0.146 46
BRIP1 BRIP1 Q9BX63 Fanconi anemia group J protein chr17 GO:0033554 Census Yes 174 0.139 397 59 0.149 6
BRSK1 BRSK1 Q8TDC3 Serine/threonine-protein kinase BRSK1 chr19 GO:0033554 Not Cancer Driver No 131 0.168 459 78 0.17 0
BRSK2_ENST00000528841 BRSK2 Q8IWQ3 Serine/threonine-protein kinase BRSK2 chr11 GO:0033554 Not Cancer Driver No 90 0.122 321 39 0.121 0
BTK_ENST00000308731 BTK Q06187 Tyrosine-protein kinase BTK chrX GO:0033554 Census, Compendium Yes 147 0.223 114 27 0.237 110
C12orf66_ENST00000398055 KICS2 Q96MD2 KICSTOR subunit 2 chr12 GO:0033554 Not Cancer Driver No 61 0.137 35 6 0.171 0
C19orf57_ENST00000586783 BRME1 Q0VDD7 Break repair meiotic recombinase recruitment factor 1 chr19 GO:0033554 Not Cancer Driver No 91 0.136 632 88 0.139 0
C2orf40 ECRG4 Q9H1Z8 Augurin chr2 GO:0033554 Not Cancer Driver No 37 0.25 23 11 0.478 0
CAB39 CAB39 Q9Y376 Calcium-binding protein 39 chr2 GO:0033554 Not Cancer Driver No 31 0.091 43 5 0.116 0
CALR CALR P27797 Calreticulin chr19 GO:0033554 Census Yes 45 0.108 245 31 0.127 0
CAMKK2 CAMKK2 Q96RR4 Calcium/calmodulin-dependent protein kinase kinase 2 chr12 GO:0033554 Not Cancer Driver No 65 0.111 281 35 0.125 0
CAPN3 CAPN3 P20807 Calpain-3 chr15 GO:0033554 Not Cancer Driver No 111 0.135 168 11 0.065 52
CASP2 CASP2 P42575 Caspase-2 chr7 GO:0033554 Not Cancer Driver No 63 0.139 42 12 0.286 0
CASP3 CASP3 P42574 Caspase-3 chr4 GO:0033554 Census Yes 32 0.116 62 5 0.081 0
CASP4 CASP4 P49662 Caspase-4 chr11 GO:0033554 Not Cancer Driver No 56 0.149 102 14 0.137 0
CAV1 CAV1 Q03135 Caveolin-1 chr7 GO:0033554 Not Cancer Driver No 30 0.169 2 0 0.0 0
CBS_ENST00000359624 CBS P35520 Cystathionine beta-synthase chr21 GO:0033554 Not Cancer Driver No 61 0.111 160 19 0.119 103
CCDC47_ENST00000403162 CCDC47 Q96A33 PAT complex subunit CCDC47 chr17 GO:0033554 Not Cancer Driver No 49 0.101 265 23 0.087 0
CCND1 CCND1 P24385 G1/S-specific cyclin-D1 chr11 GO:0033554 Census, Compendium Yes 55 0.186 31 25 0.806 0
CD36_ENST00000309881 CD36 P16671 Platelet glycoprotein 4 chr7 GO:0033554 Not Cancer Driver No 75 0.159 12 3 0.25 3
CDC37 CDC37 Q16543 Hsp90 co-chaperone Cdc37 chr19 GO:0033554 Not Cancer Driver No 52 0.138 214 31 0.145 0
CDK1 CDK1 P06493 Cyclin-dependent kinase 1 chr10 GO:0033554 Not Cancer Driver No 40 0.135 1 0 0.0 0
CDK2 CDK2 P24941 Cyclin-dependent kinase 2 chr12 GO:0033554 Not Cancer Driver No 24 0.081 0 0 0.0 0
CDKN1A_ENST00000373711 CDKN1A P38936 Cyclin-dependent kinase inhibitor 1 chr6 GO:0033554 Census, Compendium Yes 48 0.293 121 30 0.248 0
CDKN1B CDKN1B P46527 Cyclin-dependent kinase inhibitor 1B chr12 GO:0033554 Census, Compendium Yes 19 0.096 198 19 0.096 0
CDKN2A_ENST00000304494 CDKN2A P42771 Cyclin-dependent kinase inhibitor 2A chr9 GO:0033554 Census, Compendium Yes 166 1.064 83 88 1.06 36
CDKN2B CDKN2B P42772 Cyclin-dependent kinase 4 inhibitor B chr9 GO:0033554 Not Cancer Driver No 15 0.109 67 3 0.045 0
CEBPB CEBPB P17676 CCAAT/enhancer-binding protein beta chr20 GO:0033554 Not Cancer Driver No 3 0.009 276 2 0.007 0
CHAC1_ENST00000617961 CHAC1 Q9BUX1 Glutathione-specific gamma-glutamylcyclotransferase 1 chr15 GO:0033554 Not Cancer Driver No 30 0.135 49 5 0.102 0
CHD6 CHD6 Q8TD26 Chromodomain-helicase-DNA-binding protein 6 chr20 GO:0033554 Not Cancer Driver No 393 0.145 1469 213 0.145 0
CHEK1_ENST00000428830 CHEK1 O14757 Serine/threonine-protein kinase Chk1 chr11 GO:0033554 Not Cancer Driver No 58 0.122 86 16 0.186 0
CHEK2_ENST00000405598 CHEK2 O96017 Serine/threonine-protein kinase Chk2 chr22 GO:0033554 Census, Compendium Yes 335 0.617 157 130 0.828 13
CHUK CHUK O15111 Inhibitor of nuclear factor kappa-B kinase subunit alpha chr10 GO:0033554 Not Cancer Driver No 74 0.099 116 9 0.078 0
CIDEA CIDEA O60543 Cell death activator CIDE-A chr18 GO:0033554 Not Cancer Driver No 43 0.196 32 3 0.094 0
CITED2_ENST00000367651 CITED2 Q99967 Cbp/p300-interacting transactivator 2 chr6 GO:0033554 Not Cancer Driver No 23 0.085 230 18 0.078 0
COMT COMT P21964 Catechol O-methyltransferase chr22 GO:0033554 Not Cancer Driver No 21 0.077 5 0 0.0 0
CPEB4 CPEB4 Q17RY0 Cytoplasmic polyadenylation element-binding protein 4 chr5 GO:0033554 Not Cancer Driver No 85 0.117 443 54 0.122 0
CRADD_ENST00000332896 CRADD P78560 Death domain-containing protein CRADD chr12 GO:0033554 Not Cancer Driver No 35 0.176 45 5 0.111 1
CREB3L1 CREB3L1 Q96BA8 Cyclic AMP-responsive element-binding protein 3-like protein 1 chr11 GO:0033554 Census Yes 68 0.131 372 50 0.134 0
CREB3L3 CREB3L3 Q68CJ9 Cyclic AMP-responsive element-binding protein 3-like protein 3 chr19 GO:0033554 Not Cancer Driver No 96 0.208 338 67 0.198 1
CRY1 CRY1 Q16526 Cryptochrome-1 chr12 GO:0033554 Not Cancer Driver No 76 0.13 91 5 0.055 0
CRY2_ENST00000616080 CRY2 Q49AN0 Cryptochrome-2 chr11 GO:0033554 Not Cancer Driver No 72 0.121 100 12 0.12 0
CRYGD CRYGD P07320 Gamma-crystallin D chr2 GO:0033554 Not Cancer Driver No 28 0.161 0 0 0.0 6
CSPG5 CSPG5 O95196 Chondroitin sulfate proteoglycan 5 chr3 GO:0033554 Not Cancer Driver No 75 0.133 397 46 0.116 0
CTNNA1 CTNNA1 P35221 Catenin alpha-1 chr5 GO:0033554 Census Yes 126 0.139 268 35 0.131 4
CUL4B CUL4B Q13620 Cullin-4B chrX GO:0033554 Not Cancer Driver No 138 0.151 207 38 0.184 2
CYP1B1 CYP1B1 Q16678 Cytochrome P450 1B1 chr2 GO:0033554 Not Cancer Driver No 61 0.112 31 3 0.097 40
DAB2IP_ENST00000408936 DAB2IP Q5VWQ8 Disabled homolog 2-interacting protein chr9 GO:0033554 Not Cancer Driver No 131 0.11 681 68 0.1 0
DAG1_ENST00000515359 DAG1 Q14118 Dystroglycan 1 chr3 GO:0033554 Not Cancer Driver No 102 0.114 485 61 0.126 4
DAPK1_ENST00000622514 DAPK1 P53355 Death-associated protein kinase 1 chr9 GO:0033554 Not Cancer Driver No 193 0.135 114 11 0.096 0
DCLRE1A DCLRE1A Q6PJP8 DNA cross-link repair 1A protein chr10 GO:0033554 Not Cancer Driver No 92 0.088 514 45 0.088 0
DCLRE1B DCLRE1B Q9H816 5' exonuclease Apollo chr1 GO:0033554 Not Cancer Driver No 65 0.122 127 17 0.134 0
DCLRE1C DCLRE1C Q96SD1 Protein artemis chr10 GO:0033554 Not Cancer Driver No 76 0.11 277 26 0.094 3
DCTPP1 DCTPP1 Q9H773 dCTP pyrophosphatase 1 chr16 GO:0033554 Not Cancer Driver No 14 0.082 88 9 0.102 0
DDB1 DDB1 Q16531 DNA damage-binding protein 1 chr11 GO:0033554 Not Cancer Driver No 126 0.111 50 8 0.16 4
DDB2 DDB2 Q92466 DNA damage-binding protein 2 chr11 GO:0033554 Census, Compendium Yes 45 0.105 70 5 0.071 2
DDIT3_ENST00000623876 DDIT3 P35638 DNA damage-inducible transcript 3 protein chr12 GO:0033554 Census Yes 29 0.172 160 27 0.169 0
DERL1 DERL1 Q9BUN8 Derlin-1 chr8 GO:0033554 Not Cancer Driver No 28 0.112 11 1 0.091 0
DHFR DHFR P00374 Dihydrofolate reductase chr5 GO:0033554 Not Cancer Driver No 16 0.086 12 2 0.167 2
DNA2 DNA2 P51530 DNA replication ATP-dependent helicase/nuclease DNA2 chr10 GO:0033554 Not Cancer Driver No 120 0.113 52 8 0.154 3
DNAJB1 DNAJB1 P25685 DnaJ homolog subfamily B member 1 chr19 GO:0033554 Census, Compendium Yes 35 0.103 196 26 0.133 0
DNAJC10 DNAJC10 Q8IXB1 DnaJ homolog subfamily C member 10 chr2 GO:0033554 Not Cancer Driver No 110 0.139 36 3 0.083 0
DNAJC3 DNAJC3 Q13217 DnaJ homolog subfamily C member 3 chr13 GO:0033554 Not Cancer Driver No 60 0.119 131 17 0.13 0
E2F7 E2F7 Q96AV8 Transcription factor E2F7 chr12 GO:0033554 Not Cancer Driver No 122 0.134 554 70 0.126 0
ECT2 ECT2 Q9H8V3 Protein ECT2 chr3 GO:0033554 Not Cancer Driver No 104 0.114 284 33 0.116 0
EDEM1 EDEM1 Q92611 ER degradation-enhancing alpha-mannosidase-like protein 1 chr3 GO:0033554 Not Cancer Driver No 54 0.082 141 5 0.035 0
EDEM2 EDEM2 Q9BV94 ER degradation-enhancing alpha-mannosidase-like protein 2 chr20 GO:0033554 Not Cancer Driver No 69 0.119 54 3 0.056 0
EDN1 EDN1 P05305 Endothelin-1 chr6 GO:0033554 Not Cancer Driver No 37 0.175 97 20 0.206 3
EEF2K EEF2K O00418 Eukaryotic elongation factor 2 kinase chr16 GO:0033554 Not Cancer Driver No 104 0.143 311 39 0.125 0
EGFR EGFR P00533 Epidermal growth factor receptor chr7 GO:0033554 Census, Compendium Yes 444 0.367 223 35 0.157 1
EGR1 EGR1 P18146 Early growth response protein 1 chr5 GO:0033554 Not Cancer Driver No 78 0.144 501 72 0.144 0
EIF2A EIF2A Q9BY44 Eukaryotic translation initiation factor 2A chr3 GO:0033554 Not Cancer Driver No 51 0.087 162 19 0.117 0
EIF2AK1 EIF2AK1 Q9BQI3 Eukaryotic translation initiation factor 2-alpha kinase 1 chr7 GO:0033554 Not Cancer Driver No 87 0.138 238 29 0.122 0
EIF2AK3 EIF2AK3 Q9NZJ5 Eukaryotic translation initiation factor 2-alpha kinase 3 chr2 GO:0033554 Not Cancer Driver No 149 0.134 410 51 0.124 1
EIF2AK4 EIF2AK4 Q9P2K8 eIF-2-alpha kinase GCN2 chr15 GO:0033554 Not Cancer Driver No 156 0.095 494 44 0.089 2
EIF2S1 EIF2S1 P05198 Eukaryotic translation initiation factor 2 subunit 1 chr14 GO:0033554 Not Cancer Driver No 35 0.111 59 6 0.102 0
EPAS1 EPAS1 Q99814 Endothelial PAS domain-containing protein 1 chr2 GO:0033554 Census, Compendium Yes 120 0.138 449 53 0.118 6
EPO EPO P01588 Erythropoietin chr7 GO:0033554 Not Cancer Driver No 27 0.14 9 1 0.111 1
ERCC1_ENST00000589165 ERCC1 P07992 DNA excision repair protein ERCC-1 chr19 GO:0033554 Not Cancer Driver No 42 0.141 105 14 0.133 1
ERCC2 ERCC2 P18074 General transcription and DNA repair factor IIH helicase subunit XPD chr19 GO:0033554 Census, Compendium Yes 150 0.197 5 0 0.0 35
ERCC3 ERCC3 P19447 General transcription and DNA repair factor IIH helicase subunit XPB chr2 GO:0033554 Census, Compendium Yes 92 0.118 208 22 0.106 2
ERCC4 ERCC4 Q92889 DNA repair endonuclease XPF chr16 GO:0033554 Census Yes 120 0.131 225 27 0.12 15
ERCC5 ERCC5 P28715 DNA excision repair protein ERCC-5 chr13 GO:0033554 Census Yes 175 0.148 816 121 0.148 6
ERCC6 ERCC6 Q03468 DNA excision repair protein ERCC-6 chr10 GO:0033554 Not Cancer Driver No 211 0.141 829 117 0.141 9
ERCC8 ERCC8 Q13216 DNA excision repair protein ERCC-8 chr5 GO:0033554 Not Cancer Driver No 25 0.063 53 8 0.151 7
ERLIN1 ERLIN1 O75477 Erlin-1 chr10 GO:0033554 Not Cancer Driver No 29 0.083 46 4 0.087 1
ERLIN2_ENST00000519638 ERLIN2 O94905 Erlin-2 chr8 GO:0033554 Not Cancer Driver No 38 0.112 22 3 0.136 0
ERN1 ERN1 O75460 Serine/threonine-protein kinase/endoribonuclease IRE1 chr17 GO:0033554 Not Cancer Driver No 125 0.128 250 28 0.112 0
ERN2 ERN2 Q76MJ5 Serine/threonine-protein kinase/endoribonuclease IRE2 chr16 GO:0033554 Not Cancer Driver No 192 0.207 213 45 0.211 0
ERO1A ERO1A Q96HE7 ERO1-like protein alpha chr14 GO:0033554 Not Cancer Driver No 48 0.103 32 5 0.156 0
ERRFI1 ERRFI1 Q9UJM3 ERBB receptor feedback inhibitor 1 chr1 GO:0033554 Not Cancer Driver No 55 0.119 297 37 0.125 0
EZH2_ENST00000460911 EZH2 Q15910 Histone-lysine N-methyltransferase EZH2 chr7 GO:0033554 Census, Compendium Yes 120 0.161 284 44 0.155 11
FABP1 FABP1 P07148 Fatty acid-binding protein, liver chr2 GO:0033554 Not Cancer Driver No 34 0.268 0 0 0.0 0
FAM111A FAM111A Q96PZ2 Serine protease FAM111A chr11 GO:0033554 Not Cancer Driver No 78 0.128 169 23 0.136 5
FANCB FANCB Q8NB91 Fanconi anemia group B protein chrX GO:0033554 Not Cancer Driver No 109 0.127 24 5 0.208 0
FANCD2_ENST00000383807 FANCD2 Q9BXW9 Fanconi anemia group D2 protein chr3 GO:0033554 Census, Compendium Yes 176 0.121 181 14 0.077 3
FANCM FANCM Q8IYD8 Fanconi anemia group M protein chr14 GO:0033554 Not Cancer Driver No 268 0.131 898 128 0.143 0
FAS FAS P25445 Tumor necrosis factor receptor superfamily member 6 chr10 GO:0033554 Census, Compendium Yes 55 0.164 62 18 0.29 22
FBXO31 FBXO31 Q5XUX0 F-box only protein 31 chr16 GO:0033554 Not Cancer Driver No 72 0.134 231 30 0.13 0
FER FER P16591 Tyrosine-protein kinase Fer chr5 GO:0033554 Not Cancer Driver No 114 0.139 145 21 0.145 0
FOLR1_ENST00000393681 FOLR1 P15328 Folate receptor alpha chr11 GO:0033554 Not Cancer Driver No 41 0.16 13 3 0.231 0
FOS FOS P01100 Protein c-Fos chr14 GO:0033554 Not Cancer Driver No 45 0.118 245 33 0.135 0
FOXM1_ENST00000359843 FOXM1 Q08050 Forkhead box protein M1 chr12 GO:0033554 Not Cancer Driver No 97 0.127 601 73 0.121 0
FOXO1 FOXO1 Q12778 Forkhead box protein O1 chr13 GO:0033554 Census, Compendium Yes 81 0.124 584 75 0.128 0
FOXO3 FOXO3 O43524 Forkhead box protein O3 chr6 GO:0033554 Census, Compendium Yes 70 0.104 595 68 0.114 0
FXN FXN Q16595 Frataxin, mitochondrial chr9 GO:0033554 Not Cancer Driver No 16 0.076 73 0 0.0 8
GABARAP GABARAP O95166 Gamma-aminobutyric acid receptor-associated protein chr17 GO:0033554 Not Cancer Driver No 9 0.077 11 0 0.0 0
GABARAPL1_ENST00000545887 GABARAPL1 Q9H0R8 Gamma-aminobutyric acid receptor-associated protein-like 1 chr12 GO:0033554 Not Cancer Driver No 19 0.162 10 1 0.1 0
GABARAPL2 GABARAPL2 P60520 Gamma-aminobutyric acid receptor-associated protein-like 2 chr16 GO:0033554 Not Cancer Driver No 11 0.094 2 1 0.5 0
GAP43_ENST00000305124 GAP43 P17677 Neuromodulin chr3 GO:0033554 Not Cancer Driver No 79 0.332 238 79 0.332 0
GBA_ENST00000368373 GBA P04062 Lysosomal acid glucosylceramidase chr1 GO:0033554 Not Cancer Driver No 74 0.138 38 5 0.132 171
GCN1 GCN1 Q92616 eIF-2-alpha kinase activator GCN1 chr12 GO:0033554 Not Cancer Driver No 327 0.122 117 16 0.137 0
GCNA GCNA Q96QF7 Germ cell nuclear acidic protein chrX GO:0033554 Not Cancer Driver No 155 0.224 513 122 0.238 0
GFAP_ENST00000588735 GFAP P14136 Glial fibrillary acidic protein chr17 GO:0033554 Not Cancer Driver No 65 0.15 288 42 0.146 62
GIGYF2_ENST00000409547 GIGYF2 Q6Y7W6 GRB10-interacting GYF protein 2 chr2 GO:0033554 Not Cancer Driver No 176 0.135 1096 158 0.144 6
GLRX2_ENST00000367439 GLRX2 Q9NS18 Glutaredoxin-2, mitochondrial chr1 GO:0033554 Not Cancer Driver No 12 0.073 10 1 0.1 0
GML GML Q99445 Glycosyl-phosphatidylinositol-anchored molecule-like protein chr8 GO:0033554 Not Cancer Driver No 49 0.31 12 6 0.5 0
GPS2 GPS2 Q13227 G protein pathway suppressor 2 chr17 GO:0033554 Not Cancer Driver No 29 0.089 319 26 0.082 0
GSK3B_ENST00000264235 GSK3B P49841 Glycogen synthase kinase-3 beta chr3 GO:0033554 Not Cancer Driver No 56 0.133 146 13 0.089 0
GTSE1 GTSE1 Q9NYZ3 G2 and S phase-expressed protein 1 chr22 GO:0033554 Not Cancer Driver No 91 0.126 660 85 0.129 0
H2AFX H2AX P16104 Histone H2AX chr11 GO:0033554 Not Cancer Driver No 20 0.14 68 10 0.147 0
HAS2 HAS2 Q92819 Hyaluronan synthase 2 chr8 GO:0033554 Not Cancer Driver No 100 0.181 17 7 0.412 0
HDAC2 HDAC2 Q92769 Histone deacetylase 2 chr6 GO:0033554 Not Cancer Driver No 46 0.094 145 14 0.097 0
HDAC3 HDAC3 O15379 Histone deacetylase 3 chr5 GO:0033554 Not Cancer Driver No 65 0.152 61 8 0.131 0
HDAC6_ENST00000426196 HDAC6 Q9UBN7 Histone deacetylase 6 chrX GO:0033554 Not Cancer Driver No 178 0.147 409 59 0.144 0
HIF1AN HIF1AN Q9NWT6 Hypoxia-inducible factor 1-alpha inhibitor chr10 GO:0033554 Not Cancer Driver No 37 0.106 77 9 0.117 0
HIF1A_ENST00000337138 HIF1A Q16665 Hypoxia-inducible factor 1-alpha chr14 GO:0033554 Census Yes 118 0.143 435 51 0.117 0
HIPK2 HIPK2 Q9H2X6 Homeodomain-interacting protein kinase 2 chr7 GO:0033554 Not Cancer Driver No 154 0.129 686 96 0.14 0
HIST3H2A H2AW Q7L7L0 Histone H2A type 3 chr1 GO:0033554 Not Cancer Driver No 21 0.162 61 10 0.164 0
HK2 HK2 P52789 Hexokinase-2 chr2 GO:0033554 Not Cancer Driver No 138 0.15 77 7 0.091 0
HMCES_ENST00000502878 HMCES Q96FZ2 Abasic site processing protein HMCES chr3 GO:0033554 Not Cancer Driver No 37 0.105 131 16 0.122 0
HMGA1 HMGA1 P17096 High mobility group protein HMG-I/HMG-Y chr6 GO:0033554 Census Yes 6 0.056 107 6 0.056 0
HMGA2_ENST00000403681 HMGA2 P52926 High mobility group protein HMGI-C chr12 GO:0033554 Census Yes 12 0.11 109 12 0.11 0
HMOX1 HMOX1 P09601 Heme oxygenase 1 chr22 GO:0033554 Not Cancer Driver No 46 0.16 81 13 0.16 0
HNRNPA1 HNRNPA1 P09651 Heterogeneous nuclear ribonucleoprotein A1 chr12 GO:0033554 Not Cancer Driver No 70 0.188 290 58 0.2 4
HRAS HRAS P01112 GTPase HRas chr11 GO:0033554 Census, Compendium Yes 107 0.566 16 4 0.25 18
HSBP1L1 HSBP1L1 C9JCN9 Heat shock factor-binding protein 1-like protein 1 chr18 GO:0033554 Not Cancer Driver No 6 0.081 66 5 0.076 0
HSBP1_ENST00000570259 HSBP1 O75506 Heat shock factor-binding protein 1 chr16 GO:0033554 Not Cancer Driver No 6 0.079 76 6 0.079 0
HSF1 HSF1 Q00613 Heat shock factor protein 1 chr8 GO:0033554 Not Cancer Driver No 59 0.112 335 37 0.11 0
HSF2BP HSF2BP O75031 Heat shock factor 2-binding protein chr21 GO:0033554 Not Cancer Driver No 52 0.156 23 3 0.13 1
HSPA1A HSPA1A P0DMV8 Heat shock 70 kDa protein 1A chr6 GO:0033554 Not Cancer Driver No 24 0.037 200 13 0.065 0
HSPA1B HSPA1B P0DMV9 Heat shock 70 kDa protein 1B chr6 GO:0033554 Not Cancer Driver No 15 0.023 200 5 0.025 0
HSPA5 HSPA5 P11021 Endoplasmic reticulum chaperone BiP chr9 GO:0033554 Not Cancer Driver No 73 0.112 282 35 0.124 0
HSPA6 HSPA6 P17066 Heat shock 70 kDa protein 6 chr1 GO:0033554 Not Cancer Driver No 112 0.174 235 27 0.115 0
HSPD1 HSPD1 P10809 60 kDa heat shock protein, mitochondrial chr2 GO:0033554 Not Cancer Driver No 61 0.106 82 6 0.073 2
HTRA2 HTRA2 O43464 Serine protease HTRA2, mitochondrial chr2 GO:0033554 Compendium Yes 44 0.096 127 9 0.071 2
HUWE1_ENST00000262854 HUWE1 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 chrX GO:0033554 Not Cancer Driver No 669 0.153 2091 329 0.157 21
ID2_ENST00000396290 ID2 Q02363 DNA-binding protein inhibitor ID-2 chr2 GO:0033554 Not Cancer Driver No 14 0.104 52 7 0.135 0
IFI16_ENST00000295809 IFI16 Q16666 Gamma-interferon-inducible protein 16 chr1 GO:0033554 Not Cancer Driver No 155 0.197 419 90 0.215 0
IGF1R IGF1R P08069 Insulin-like growth factor 1 receptor chr15 GO:0033554 Not Cancer Driver No 183 0.134 265 37 0.14 6
IL18BP_ENST00000337131 IL18BP O95998 Interleukin-18-binding protein chr11 GO:0033554 Not Cancer Driver No 16 0.082 50 6 0.12 0
IL6 IL6 P05231 Interleukin-6 chr7 GO:0033554 Not Cancer Driver No 35 0.165 58 7 0.121 0
IMPACT IMPACT Q9P2X3 Protein IMPACT chr18 GO:0033554 Not Cancer Driver No 49 0.153 84 12 0.143 0
ING4 ING4 Q9UNL4 Inhibitor of growth protein 4 chr12 GO:0033554 Not Cancer Driver No 31 0.124 108 15 0.139 0
INO80_ENST00000401393 INO80 Q9ULG1 Chromatin-remodeling ATPase INO80 chr15 GO:0033554 Compendium Yes 173 0.111 682 76 0.111 0
INSIG1 INSIG1 O15503 Insulin-induced gene 1 protein chr7 GO:0033554 Not Cancer Driver No 37 0.134 43 1 0.023 0
INSIG2 INSIG2 Q9Y5U4 Insulin-induced gene 2 protein chr2 GO:0033554 Not Cancer Driver No 47 0.209 11 3 0.273 0
ISL1 ISL1 P61371 Insulin gene enhancer protein ISL-1 chr5 GO:0033554 Not Cancer Driver No 85 0.244 180 41 0.228 0
ITFG2 ITFG2 Q969R8 KICSTOR complex protein ITFG2 chr12 GO:0033554 Not Cancer Driver No 59 0.132 61 9 0.148 0
ITPR1_ENST00000354582 ITPR1 Q14643 Inositol 1,4,5-trisphosphate receptor type 1 chr3 GO:0033554 Not Cancer Driver No 390 0.141 581 76 0.131 6
JAK2 JAK2 O60674 Tyrosine-protein kinase JAK2 chr9 GO:0033554 Census, Compendium Yes 136 0.12 59 5 0.085 5
JUN JUN P05412 Transcription factor Jun chr1 GO:0033554 Census Yes 35 0.106 281 25 0.089 0
KAT5_ENST00000377046 KAT5 Q92993 Histone acetyltransferase KAT5 chr11 GO:0033554 Not Cancer Driver No 65 0.127 173 21 0.121 3
KAT6A_ENST00000406337 KAT6A Q92794 Histone acetyltransferase KAT6A chr8 GO:0033554 Census, Compendium Yes 273 0.136 1420 193 0.136 0
KDM6B_ENST00000448097 KDM6B O15054 Lysine-specific demethylase 6B chr17 GO:0033554 Not Cancer Driver No 189 0.115 1278 142 0.111 2
KLF2 KLF2 Q9Y5W3 Krueppel-like factor 2 chr19 GO:0033554 Not Cancer Driver No 13 0.037 280 4 0.014 0
KPTN KPTN Q9Y664 KICSTOR complex protein kaptin chr19 GO:0033554 Not Cancer Driver No 44 0.101 21 2 0.095 0
LARS LARS1 Q9P2J5 Leucine--tRNA ligase, cytoplasmic chr5 GO:0033554 Not Cancer Driver No 133 0.113 97 10 0.103 1
LGALS9 LGALS9 O00182 Galectin-9 chr17 GO:0033554 Not Cancer Driver No 54 0.152 65 16 0.246 0
LIG3 LIG3 P49916 DNA ligase 3 chr17 GO:0033554 Not Cancer Driver No 125 0.124 280 36 0.129 0
LIG4 LIG4 P49917 DNA ligase 4 chr13 GO:0033554 Not Cancer Driver No 134 0.147 63 10 0.159 2
MAD2L2 MAD2L2 Q9UI95 Mitotic spindle assembly checkpoint protein MAD2B chr1 GO:0033554 Not Cancer Driver No 22 0.104 0 0 0.0 1
MAG_ENST00000537831 MAG P20916 Myelin-associated glycoprotein chr19 GO:0033554 Not Cancer Driver No 118 0.188 65 7 0.108 1
MAP1B MAP1B P46821 Microtubule-associated protein 1B chr5 GO:0033554 Not Cancer Driver No 332 0.135 1947 278 0.143 0
MAP1LC3A_ENST00000397709 MAP1LC3A Q9H492 Microtubule-associated proteins 1A/1B light chain 3A chr20 GO:0033554 Not Cancer Driver No 22 0.182 24 1 0.042 0
MAP1LC3B MAP1LC3B Q9GZQ8 Microtubule-associated proteins 1A/1B light chain 3B chr16 GO:0033554 Not Cancer Driver No 10 0.08 17 1 0.059 0
MAP1LC3B2 MAP1LC3B2 A6NCE7 Microtubule-associated proteins 1A/1B light chain 3 beta 2 chr12 GO:0033554 Not Cancer Driver No 19 0.152 17 7 0.412 0
MAP1LC3C MAP1LC3C Q9BXW4 Microtubule-associated proteins 1A/1B light chain 3C chr1 GO:0033554 Not Cancer Driver No 32 0.218 31 5 0.161 0
MAP2K1 MAP2K1 Q02750 Dual specificity mitogen-activated protein kinase kinase 1 chr15 GO:0033554 Census, Compendium Yes 94 0.239 96 24 0.25 6
MAP2K3 MAP2K3 P46734 Dual specificity mitogen-activated protein kinase kinase 3 chr17 GO:0033554 Not Cancer Driver No 104 0.3 75 27 0.36 0
MAP2K4_ENST00000353533 MAP2K4 P45985 Dual specificity mitogen-activated protein kinase kinase 4 chr17 GO:0033554 Census, Compendium Yes 89 0.223 137 28 0.204 0
MAP2K5 MAP2K5 Q13163 Dual specificity mitogen-activated protein kinase kinase 5 chr15 GO:0033554 Not Cancer Driver No 40 0.089 85 10 0.118 0
MAP2K6 MAP2K6 P52564 Dual specificity mitogen-activated protein kinase kinase 6 chr17 GO:0033554 Not Cancer Driver No 48 0.144 55 11 0.2 0
MAP2K7_ENST00000397979 MAP2K7 O14733 Dual specificity mitogen-activated protein kinase kinase 7 chr19 GO:0033554 Compendium Yes 89 0.212 144 20 0.139 0
MAP3K15 MAP3K15 Q6ZN16 Mitogen-activated protein kinase kinase kinase 15 chrX GO:0033554 Not Cancer Driver No 206 0.157 315 39 0.124 0
MAP3K20 MAP3K20 Q9NYL2 Mitogen-activated protein kinase kinase kinase 20 chr2 GO:0033554 Not Cancer Driver No 101 0.126 294 41 0.139 1
MAP3K5 MAP3K5 Q99683 Mitogen-activated protein kinase kinase kinase 5 chr6 GO:0033554 Not Cancer Driver No 197 0.143 242 29 0.12 0
MAP3K6 MAP3K6 O95382 Mitogen-activated protein kinase kinase kinase 6 chr1 GO:0033554 Not Cancer Driver No 108 0.084 390 31 0.079 0
MAP3K7 MAP3K7 O43318 Mitogen-activated protein kinase kinase kinase 7 chr6 GO:0033554 Not Cancer Driver No 104 0.172 333 66 0.198 6
MAPK10_ENST00000515650 MAPK10 P53779 Mitogen-activated protein kinase 10 chr4 GO:0033554 Not Cancer Driver No 88 0.19 107 16 0.15 0
MAPK11 MAPK11 Q15759 Mitogen-activated protein kinase 11 chr22 GO:0033554 Not Cancer Driver No 23 0.063 64 2 0.031 0
MAPK12 MAPK12 P53778 Mitogen-activated protein kinase 12 chr22 GO:0033554 Not Cancer Driver No 31 0.084 63 5 0.079 0
MAPK13 MAPK13 O15264 Mitogen-activated protein kinase 13 chr6 GO:0033554 Not Cancer Driver No 51 0.14 50 15 0.3 0
MAPK14_ENST00000229794 MAPK14 Q16539 Mitogen-activated protein kinase 14 chr6 GO:0033554 Not Cancer Driver No 39 0.108 25 1 0.04 0
MAPK1_ENST00000398822 MAPK1 P28482 Mitogen-activated protein kinase 1 chr22 GO:0033554 Census, Compendium Yes 62 0.172 2 0 0.0 7
MAPK3 MAPK3 P27361 Mitogen-activated protein kinase 3 chr16 GO:0033554 Not Cancer Driver No 38 0.1 49 5 0.102 0
MAPK7 MAPK7 Q13164 Mitogen-activated protein kinase 7 chr17 GO:0033554 Not Cancer Driver No 92 0.113 490 50 0.102 0
MAPK8IP3_ENST00000250894 MAPK8IP3 Q9UPT6 C-Jun-amino-terminal kinase-interacting protein 3 chr16 GO:0033554 Not Cancer Driver No 179 0.134 746 110 0.147 3
MAPK8_ENST00000374189 MAPK8 P45983 Mitogen-activated protein kinase 8 chr10 GO:0033554 Not Cancer Driver No 64 0.15 94 9 0.096 0
MAPK9 MAPK9 P45984 Mitogen-activated protein kinase 9 chr5 GO:0033554 Not Cancer Driver No 59 0.139 90 8 0.089 0
MAPKAPK2 MAPKAPK2 P49137 MAP kinase-activated protein kinase 2 chr1 GO:0033554 Not Cancer Driver No 43 0.107 92 5 0.054 0
MAPKAPK5 MAPKAPK5 Q8IW41 MAP kinase-activated protein kinase 5 chr12 GO:0033554 Not Cancer Driver No 51 0.108 101 12 0.119 0
MAPT_ENST00000262410 MAPT P10636 Microtubule-associated protein tau chr17 GO:0033554 Not Cancer Driver No 128 0.169 750 126 0.168 18
MBTPS1 MBTPS1 Q14703 Membrane-bound transcription factor site-1 protease chr16 GO:0033554 Not Cancer Driver No 140 0.133 206 36 0.175 1
MBTPS2 MBTPS2 O43462 Membrane-bound transcription factor site-2 protease chrX GO:0033554 Not Cancer Driver No 63 0.121 16 4 0.25 9
MC1R_ENST00000639847 MC1R Q01726 Melanocyte-stimulating hormone receptor chr16 GO:0033554 Not Cancer Driver No 39 0.123 0 0 0.0 5
MCM8_ENST00000378896 MCM8 Q9UJA3 DNA helicase MCM8 chr20 GO:0033554 Not Cancer Driver No 94 0.112 188 19 0.101 1
MCM9_ENST00000619706 MCM9 Q9NXL9 DNA helicase MCM9 chr6 GO:0033554 Not Cancer Driver No 56 0.049 523 13 0.025 0
MDM2_ENST00000539479 MDM2 Q00987 E3 ubiquitin-protein ligase Mdm2 chr12 GO:0033554 Census, Compendium Yes 56 0.114 297 37 0.125 0
MDM4 MDM4 O15151 Protein Mdm4 chr1 GO:0033554 Census, Compendium Yes 57 0.116 202 26 0.129 1
MEF2C_ENST00000504921 MEF2C Q06413 Myocyte-specific enhancer factor 2C chr5 GO:0033554 Not Cancer Driver No 92 0.195 408 81 0.199 0
MFN2_ENST00000444836 MFN2 O95140 Mitofusin-2 chr1 GO:0033554 Not Cancer Driver No 80 0.106 81 9 0.111 20
MGME1 MGME1 Q9BQP7 Mitochondrial genome maintenance exonuclease 1 chr20 GO:0033554 Not Cancer Driver No 33 0.096 95 7 0.074 1
MGST1_ENST00000396210 MGST1 P10620 Microsomal glutathione S-transferase 1 chr12 GO:0033554 Not Cancer Driver No 26 0.168 0 0 0.0 0
MIF MIF P14174 Macrophage migration inhibitory factor chr22 GO:0033554 Not Cancer Driver No 4 0.035 0 0 0.0 0
MMP2 MMP2 P08253 72 kDa type IV collagenase chr16 GO:0033554 Not Cancer Driver No 123 0.186 29 6 0.207 2
MMP9 MMP9 P14780 Matrix metalloproteinase-9 chr20 GO:0033554 Not Cancer Driver No 129 0.182 124 26 0.21 0
MPV17 MPV17 P39210 Protein Mpv17 chr2 GO:0033554 Not Cancer Driver No 21 0.119 0 0 0.0 16
MRE11 MRE11 P49959 Double-strand break repair protein MRE11 chr11 GO:0033554 Not Cancer Driver No 84 0.119 292 35 0.12 1
MSH6 MSH6 P52701 DNA mismatch repair protein Msh6 chr2 GO:0033554 Census Yes 154 0.113 386 41 0.106 6
MT3 MT3 P25713 Metallothionein-3 chr16 GO:0033554 Not Cancer Driver No 7 0.103 0 0 0.0 0
MTMR3 MTMR3 Q13615 Myotubularin-related protein 3 chr22 GO:0033554 Not Cancer Driver No 130 0.109 501 66 0.132 0
MTOR MTOR P42345 Serine/threonine-protein kinase mTOR chr1 GO:0033554 Census, Compendium Yes 379 0.149 296 37 0.125 18
MTR MTR Q99707 Methionine synthase chr1 GO:0033554 Not Cancer Driver No 151 0.119 104 17 0.163 2
MTSS1_ENST00000518547 MTSS1 O43312 Protein MTSS 1 chr8 GO:0033554 Not Cancer Driver No 107 0.142 584 86 0.147 0
MUC1_ENST00000611571 MUC1 P15941 Mucin-1 chr1 GO:0033554 Census Yes 40 0.032 1050 19 0.018 0
MUL1 MUL1 Q969V5 Mitochondrial ubiquitin ligase activator of NFKB 1 chr1 GO:0033554 Not Cancer Driver No 48 0.136 16 2 0.125 0
MYBBP1A_ENST00000254718 MYBBP1A Q9BQG0 Myb-binding protein 1A chr17 GO:0033554 Not Cancer Driver No 144 0.108 463 47 0.102 0
MYC_ENST00000377970 MYC P01106 Myc proto-oncogene protein chr8 GO:0033554 Census, Compendium Yes 80 0.182 299 46 0.154 0
MYLK MYLK Q15746 Myosin light chain kinase, smooth muscle chr3 GO:0033554 Not Cancer Driver No 343 0.179 957 184 0.192 3
MYO6 MYO6 Q9UM54 Unconventional myosin-VI chr6 GO:0033554 Not Cancer Driver No 176 0.136 342 41 0.12 3
NBN NBN O60934 Nibrin chr8 GO:0033554 Census Yes 90 0.119 417 54 0.129 1
NCF1 NCF1 P14598 Neutrophil cytosol factor 1 chr7 GO:0033554 Not Cancer Driver No 37 0.095 181 12 0.066 1
NCK1_ENST00000288986 NCK1 P16333 Cytoplasmic protein NCK1 chr3 GO:0033554 Not Cancer Driver No 48 0.127 111 17 0.153 0
NCK2_ENST00000393349 NCK2 O43639 Cytoplasmic protein NCK2 chr2 GO:0033554 Not Cancer Driver No 89 0.234 88 19 0.216 0
NDRG1 NDRG1 Q92597 Protein NDRG1 chr8 GO:0033554 Census Yes 66 0.168 140 22 0.157 0
NEDD4 NEDD4 P46934 E3 ubiquitin-protein ligase NEDD4 chr15 GO:0033554 Not Cancer Driver No 150 0.114 711 79 0.111 0
NEFL NEFL P07196 Neurofilament light polypeptide chr8 GO:0033554 Not Cancer Driver No 92 0.169 285 39 0.137 12
NET1 NET1 Q7Z628 Neuroepithelial cell-transforming gene 1 protein chr10 GO:0033554 Not Cancer Driver No 60 0.101 294 37 0.126 0
NFE2L2 NFE2L2 Q16236 Nuclear factor erythroid 2-related factor 2 chr2 GO:0033554 Census, Compendium Yes 228 0.377 402 62 0.154 4
NFKBIA NFKBIA P25963 NF-kappa-B inhibitor alpha chr14 GO:0033554 Compendium Yes 37 0.117 102 9 0.088 1
NGLY1 NGLY1 Q96IV0 Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase chr3 GO:0033554 Not Cancer Driver No 79 0.121 98 13 0.133 0
NIM1K NIM1K Q8IY84 Serine/threonine-protein kinase NIM1 chr5 GO:0033554 Not Cancer Driver No 73 0.167 126 21 0.167 0
NIPBL NIPBL Q6KC79 Nipped-B-like protein chr5 GO:0033554 Compendium Yes 353 0.126 1528 184 0.12 37
NME8_ENST00000440017 NME8 Q8N427 Thioredoxin domain-containing protein 3 chr7 GO:0033554 Not Cancer Driver No 178 0.303 87 44 0.506 0
NOTCH1 NOTCH1 P46531 Neurogenic locus notch homolog protein 1 chr9 GO:0033554 Census, Compendium Yes 363 0.142 686 87 0.127 3
NOX1 NOX1 Q9Y5S8 NADPH oxidase 1 chrX GO:0033554 Not Cancer Driver No 101 0.179 18 8 0.444 0
NPC1L1 NPC1L1 Q9UHC9 NPC1-like intracellular cholesterol transporter 1 chr7 GO:0033554 Not Cancer Driver No 222 0.163 8 2 0.25 0
NQO1 NQO1 P15559 NAD(P)H dehydrogenase [quinone] 1 chr16 GO:0033554 Not Cancer Driver No 21 0.077 10 1 0.1 0
NREP_ENST00000447165 NREP Q16612 Neuronal regeneration-related protein chr5 GO:0033554 Not Cancer Driver No 17 0.25 36 13 0.361 0
NSMCE2_ENST00000522563 NSMCE2 Q96MF7 E3 SUMO-protein ligase NSE2 chr8 GO:0033554 Not Cancer Driver No 30 0.121 119 12 0.101 0
NUAK1 NUAK1 O60285 NUAK family SNF1-like kinase 1 chr12 GO:0033554 Not Cancer Driver No 142 0.215 357 77 0.216 0
NUDT15 NUDT15 Q9NV35 Nucleotide triphosphate diphosphatase NUDT15 chr13 GO:0033554 Not Cancer Driver No 24 0.146 37 3 0.081 0
NUDT1_ENST00000397046 NUDT1 P36639 Oxidized purine nucleoside triphosphate hydrolase chr7 GO:0033554 Not Cancer Driver No 25 0.16 17 4 0.235 0
OMA1 OMA1 Q96E52 Metalloendopeptidase OMA1, mitochondrial chr1 GO:0033554 Not Cancer Driver No 52 0.099 34 4 0.118 0
OMG OMG P23515 Oligodendrocyte-myelin glycoprotein chr17 GO:0033554 Not Cancer Driver No 38 0.086 122 10 0.082 0
OPA1_ENST00000392438 OPA1 O60313 Dynamin-like 120 kDa protein, mitochondrial chr3 GO:0033554 Not Cancer Driver No 114 0.119 131 17 0.13 60
OPTN_ENST00000263036 OPTN Q96CV9 Optineurin chr10 GO:0033554 Not Cancer Driver No 58 0.101 470 51 0.109 6
OSER1 OSER1 Q9NX31 Oxidative stress-responsive serine-rich protein 1 chr20 GO:0033554 Not Cancer Driver No 32 0.11 221 28 0.127 0
OXR1 OXR1 Q8N573 Oxidation resistance protein 1 chr8 GO:0033554 Not Cancer Driver No 126 0.144 544 76 0.14 0
OXSR1 OXSR1 O95747 Serine/threonine-protein kinase OSR1 chr3 GO:0033554 Not Cancer Driver No 69 0.131 208 29 0.139 0
PARK7_ENST00000377488 PARK7 Q99497 Parkinson disease protein 7 chr1 GO:0033554 Not Cancer Driver No 11 0.058 30 0 0.0 5
PARP1 PARP1 P09874 Poly [ADP-ribose] polymerase 1 chr1 GO:0033554 Not Cancer Driver No 119 0.117 320 34 0.106 0
PARP16 PARP16 Q8N5Y8 Protein mono-ADP-ribosyltransferase PARP16 chr15 GO:0033554 Not Cancer Driver No 37 0.115 33 3 0.091 0
PAX2_ENST00000428433 PAX2 Q02962 Paired box protein Pax-2 chr10 GO:0033554 Not Cancer Driver No 62 0.149 296 48 0.162 23
PAXIP1 PAXIP1 Q6ZW49 PAX-interacting protein 1 chr7 GO:0033554 Not Cancer Driver No 120 0.112 461 39 0.085 0
PCK1 PCK1 P35558 Phosphoenolpyruvate carboxykinase, cytosolic [GTP] chr20 GO:0033554 Not Cancer Driver No 142 0.228 110 28 0.255 1
PCNA PCNA P12004 Proliferating cell nuclear antigen chr20 GO:0033554 Not Cancer Driver No 30 0.115 22 3 0.136 1
PDGFD PDGFD Q9GZP0 Platelet-derived growth factor D chr11 GO:0033554 Not Cancer Driver No 85 0.23 37 13 0.351 0
PDGFRA PDGFRA P16234 Platelet-derived growth factor receptor alpha chr4 GO:0033554 Census, Compendium Yes 290 0.266 173 45 0.26 2
PDK2 PDK2 Q15119 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial chr17 GO:0033554 Not Cancer Driver No 45 0.111 35 4 0.114 0
PICK1 PICK1 Q9NRD5 PRKCA-binding protein chr22 GO:0033554 Not Cancer Driver No 50 0.12 49 3 0.061 0
PIDD1 PIDD1 Q9HB75 p53-induced death domain-containing protein 1 chr11 GO:0033554 Not Cancer Driver No 93 0.102 137 14 0.102 0
PIK3C3 PIK3C3 Q8NEB9 Phosphatidylinositol 3-kinase catalytic subunit type 3 chr18 GO:0033554 Not Cancer Driver No 127 0.143 191 34 0.178 0
PIK3CA PIK3CA P42336 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform chr3 GO:0033554 Census, Compendium Yes 1669 1.563 38 11 0.289 30
PIK3R4 PIK3R4 Q99570 Phosphoinositide 3-kinase regulatory subunit 4 chr3 GO:0033554 Not Cancer Driver No 193 0.142 315 45 0.143 0
PINK1 PINK1 Q9BXM7 Serine/threonine-protein kinase PINK1, mitochondrial chr1 GO:0033554 Not Cancer Driver No 57 0.098 99 13 0.131 23
PKD2 PKD2 Q13563 Polycystin-2 chr4 GO:0033554 Not Cancer Driver No 113 0.117 375 35 0.093 10
PLA2R1 PLA2R1 Q13018 Secretory phospholipase A2 receptor chr2 GO:0033554 Not Cancer Driver No 202 0.138 39 2 0.051 0
PLEC PLEC Q15149 Plectin chr8 GO:0033554 Not Cancer Driver No 677 0.145 2130 272 0.128 2
PLEKHA1 PLEKHA1 Q9HB21 Pleckstrin homology domain-containing family A member 1 chr10 GO:0033554 Not Cancer Driver No 61 0.151 191 32 0.168 0
PLIN1_ENST00000430628 PLIN1 O60240 Perilipin-1 chr15 GO:0033554 Not Cancer Driver No 43 0.082 304 20 0.066 0
PLK2 PLK2 Q9NYY3 Serine/threonine-protein kinase PLK2 chr5 GO:0033554 Not Cancer Driver No 92 0.134 178 21 0.118 0
PLK3 PLK3 Q9H4B4 Serine/threonine-protein kinase PLK3 chr1 GO:0033554 Not Cancer Driver No 75 0.116 202 15 0.074 0
PMAIP1 PMAIP1 Q13794 Phorbol-12-myristate-13-acetate-induced protein 1 chr18 GO:0033554 Not Cancer Driver No 2 0.037 23 1 0.043 0
PML PML P29590 Protein PML chr15 GO:0033554 Census, Compendium Yes 112 0.127 312 34 0.109 0
POLB POLB P06746 DNA polymerase beta chr8 GO:0033554 Not Cancer Driver No 43 0.128 87 11 0.126 0
POLD1_ENST00000440232 POLD1 P28340 DNA polymerase delta catalytic subunit chr19 GO:0033554 Census, Compendium Yes 179 0.162 214 31 0.145 2
POLD2_ENST00000452185 POLD2 P49005 DNA polymerase delta subunit 2 chr7 GO:0033554 Not Cancer Driver No 49 0.104 65 3 0.046 0
POLD3 POLD3 Q15054 DNA polymerase delta subunit 3 chr11 GO:0033554 Not Cancer Driver No 51 0.109 326 39 0.12 0
POLDIP2 POLDIP2 Q9Y2S7 Polymerase delta-interacting protein 2 chr17 GO:0033554 Not Cancer Driver No 36 0.098 94 13 0.138 0
POLE POLE Q07864 DNA polymerase epsilon catalytic subunit A chr12 GO:0033554 Census, Compendium Yes 409 0.179 239 44 0.184 3
POLE2 POLE2 P56282 DNA polymerase epsilon subunit 2 chr14 GO:0033554 Not Cancer Driver No 53 0.101 32 2 0.062 0
POLH POLH Q9Y253 DNA polymerase eta chr6 GO:0033554 Not Cancer Driver No 72 0.101 291 20 0.069 10
POLI POLI Q9UNA4 DNA polymerase iota chr18 GO:0033554 Not Cancer Driver No 82 0.111 300 32 0.107 0
POLK POLK Q9UBT6 DNA polymerase kappa chr5 GO:0033554 Not Cancer Driver No 97 0.111 293 36 0.123 0
POLQ POLQ O75417 DNA polymerase theta chr3 GO:0033554 Census, Compendium Yes 364 0.141 949 135 0.142 0
POLR2D POLR2D O15514 DNA-directed RNA polymerase II subunit RPB4 chr2 GO:0033554 Not Cancer Driver No 13 0.092 54 2 0.037 0
POLR2I POLR2I P36954 DNA-directed RNA polymerase II subunit RPB9 chr19 GO:0033554 Not Cancer Driver No 21 0.168 22 5 0.227 0
PPARGC1B PPARGC1B Q86YN6 Peroxisome proliferator-activated receptor gamma coactivator 1-beta chr5 GO:0033554 Not Cancer Driver No 125 0.122 845 99 0.117 0
PPIF PPIF P30405 Peptidyl-prolyl cis-trans isomerase F, mitochondrial chr10 GO:0033554 Not Cancer Driver No 19 0.092 43 4 0.093 0
PPM1D PPM1D O15297 Protein phosphatase 1D chr17 GO:0033554 Census, Compendium Yes 54 0.089 370 32 0.086 0
PPP1R15A PPP1R15A O75807 Protein phosphatase 1 regulatory subunit 15A chr19 GO:0033554 Not Cancer Driver No 83 0.123 628 72 0.115 0
PPP1R15B PPP1R15B Q5SWA1 Protein phosphatase 1 regulatory subunit 15B chr1 GO:0033554 Not Cancer Driver No 72 0.101 415 45 0.108 1
PRAP1 PRAP1 Q96NZ9 Proline-rich acidic protein 1 chr10 GO:0033554 Not Cancer Driver No 14 0.093 124 13 0.105 0
PRDM9 PRDM9 Q9NQV7 Histone-lysine N-methyltransferase PRDM9 chr5 GO:0033554 Not Cancer Driver No 494 0.553 372 201 0.54 0
PRDX1_ENST00000319248 PRDX1 Q06830 Peroxiredoxin-1 chr1 GO:0033554 Not Cancer Driver No 22 0.111 40 5 0.125 0
PRDX2 PRDX2 P32119 Peroxiredoxin-2 chr19 GO:0033554 Not Cancer Driver No 24 0.121 30 4 0.133 0
PRDX3 PRDX3 P30048 Thioredoxin-dependent peroxide reductase, mitochondrial chr10 GO:0033554 Not Cancer Driver No 23 0.09 23 3 0.13 0
PRDX4 PRDX4 Q13162 Peroxiredoxin-4 chrX GO:0033554 Not Cancer Driver No 36 0.133 29 2 0.069 0
PRDX5 PRDX5 P30044 Peroxiredoxin-5, mitochondrial chr11 GO:0033554 Not Cancer Driver No 22 0.103 0 0 0.0 0
PRIMPOL_ENST00000503752 PRIMPOL Q96LW4 DNA-directed primase/polymerase protein chr4 GO:0033554 Not Cancer Driver No 50 0.089 92 7 0.076 0
PRKAA1_ENST00000397128 PRKAA1 Q13131 5'-AMP-activated protein kinase catalytic subunit alpha-1 chr5 GO:0033554 Not Cancer Driver No 72 0.129 124 17 0.137 0
PRKAA2 PRKAA2 P54646 5'-AMP-activated protein kinase catalytic subunit alpha-2 chr1 GO:0033554 Not Cancer Driver No 128 0.232 98 26 0.265 0
PRKACA PRKACA P17612 cAMP-dependent protein kinase catalytic subunit alpha chr19 GO:0033554 Census Yes 53 0.151 24 0 0.0 2
PRKAG1_ENST00000548065 PRKAG1 P54619 5'-AMP-activated protein kinase subunit gamma-1 chr12 GO:0033554 Not Cancer Driver No 35 0.106 25 2 0.08 0
PRKAG2 PRKAG2 Q9UGJ0 5'-AMP-activated protein kinase subunit gamma-2 chr7 GO:0033554 Not Cancer Driver No 76 0.134 240 45 0.188 7
PRKAG3_ENST00000529249 PRKAG3 Q9UGI9 5'-AMP-activated protein kinase subunit gamma-3 chr2 GO:0033554 Not Cancer Driver No 74 0.151 144 25 0.174 0
PRKCD_ENST00000330452 PRKCD Q05655 Protein kinase C delta type chr3 GO:0033554 Compendium Yes 79 0.117 43 9 0.209 0
PRKD1_ENST00000616995 PRKD1 Q15139 Serine/threonine-protein kinase D1 chr14 GO:0033554 Census Yes 201 0.22 189 33 0.175 2
PRKDC PRKDC P78527 DNA-dependent protein kinase catalytic subunit chr8 GO:0033554 Not Cancer Driver No 538 0.13 421 61 0.145 2
PRKN PRKN O60260 E3 ubiquitin-protein ligase parkin chr6 GO:0033554 Not Cancer Driver No 110 0.237 78 15 0.192 31
PRMT6 PRMT6 Q96LA8 Protein arginine N-methyltransferase 6 chr1 GO:0033554 Not Cancer Driver No 43 0.115 71 7 0.099 0
PTGS2 PTGS2 P35354 Prostaglandin G/H synthase 2 chr1 GO:0033554 Not Cancer Driver No 105 0.174 30 5 0.167 0
PTK2B_ENST00000346049 PTK2B Q14289 Protein-tyrosine kinase 2-beta chr8 GO:0033554 Not Cancer Driver No 161 0.16 261 37 0.142 0
PTN PTN P21246 Pleiotrophin chr7 GO:0033554 Not Cancer Driver No 43 0.256 51 11 0.216 0
PTPN1 PTPN1 P18031 Tyrosine-protein phosphatase non-receptor type 1 chr20 GO:0033554 Not Cancer Driver No 49 0.113 140 25 0.179 0
PTPRF PTPRF P10586 Receptor-type tyrosine-protein phosphatase F chr1 GO:0033554 Not Cancer Driver No 268 0.141 696 96 0.138 0
PTPRK_ENST00000368215 PTPRK Q15262 Receptor-type tyrosine-protein phosphatase kappa chr6 GO:0033554 Census, Compendium Yes 292 0.203 302 57 0.189 0
PXN_ENST00000228307 PXN P49023 Paxillin chr12 GO:0033554 Not Cancer Driver No 62 0.105 341 24 0.07 0
QRICH1_ENST00000357496 QRICH1 Q2TAL8 Transcriptional regulator QRICH1 chr3 GO:0033554 Not Cancer Driver No 93 0.12 423 55 0.13 0
RAD21 RAD21 O60216 Double-strand-break repair protein rad21 homolog chr8 GO:0033554 Census, Compendium Yes 115 0.182 421 74 0.176 3
RAD21L1 RAD21L1 Q9H4I0 Double-strand-break repair protein rad21-like protein 1 chr20 GO:0033554 Not Cancer Driver No 37 0.067 186 5 0.027 0
RAD51_ENST00000267868 RAD51 Q06609 DNA repair protein RAD51 homolog 1 chr15 GO:0033554 Not Cancer Driver No 42 0.124 47 5 0.106 3
RAD52 RAD52 P43351 DNA repair protein RAD52 homolog chr12 GO:0033554 Not Cancer Driver No 41 0.098 251 30 0.12 0
RAD54L_ENST00000442598 RAD54L Q92698 DNA repair and recombination protein RAD54-like chr1 GO:0033554 Not Cancer Driver No 79 0.106 124 13 0.105 0
RBBP7_ENST00000380087 RBBP7 Q16576 Histone-binding protein RBBP7 chrX GO:0033554 Not Cancer Driver No 67 0.158 138 19 0.138 0
RBPJ_ENST00000361572 RBPJ Q06330 Recombining binding protein suppressor of hairless chr4 GO:0033554 Not Cancer Driver No 49 0.098 151 19 0.126 2
RCHY1 RCHY1 Q96PM5 RING finger and CHY zinc finger domain-containing protein 1 chr4 GO:0033554 Not Cancer Driver No 33 0.126 23 0 0.0 0
RCSD1 RCSD1 Q6JBY9 CapZ-interacting protein chr1 GO:0033554 Not Cancer Driver No 70 0.168 416 70 0.168 0
REC8_ENST00000611366 REC8 O95072 Meiotic recombination protein REC8 homolog chr14 GO:0033554 Not Cancer Driver No 60 0.11 244 26 0.107 0
RECQL5 RECQL5 O94762 ATP-dependent DNA helicase Q5 chr17 GO:0033554 Not Cancer Driver No 132 0.133 495 71 0.143 0
REL REL Q04864 Proto-oncogene c-Rel chr2 GO:0033554 Census Yes 68 0.11 363 43 0.118 0
RELA RELA Q04206 Transcription factor p65 chr11 GO:0033554 Compendium Yes 75 0.136 400 48 0.12 0
RELB RELB Q01201 Transcription factor RelB chr19 GO:0033554 Not Cancer Driver No 65 0.112 348 39 0.112 0
REV1 REV1 Q9UBZ9 DNA repair protein REV1 chr2 GO:0033554 Not Cancer Driver No 122 0.098 660 67 0.102 0
REV3L_ENST00000368802 REV3L O60673 DNA polymerase zeta catalytic subunit chr6 GO:0033554 Not Cancer Driver No 379 0.121 1665 211 0.127 0
RFWD3 RFWD3 Q6PCD5 E3 ubiquitin-protein ligase RFWD3 chr16 GO:0033554 Census Yes 68 0.088 318 30 0.094 1
RGS14 RGS14 O43566 Regulator of G-protein signaling 14 chr5 GO:0033554 Not Cancer Driver No 57 0.101 309 37 0.12 0
RHOB RHOB P62745 Rho-related GTP-binding protein RhoB chr2 GO:0033554 Not Cancer Driver No 52 0.265 19 2 0.105 0
RIF1 RIF1 Q5UIP0 Telomere-associated protein RIF1 chr2 GO:0033554 Not Cancer Driver No 287 0.116 1355 164 0.121 0
RIPK1_ENST00000380409 RIPK1 Q13546 Receptor-interacting serine/threonine-protein kinase 1 chr6 GO:0033554 Compendium Yes 82 0.122 277 39 0.141 4
RIPK3 RIPK3 Q9Y572 Receptor-interacting serine/threonine-protein kinase 3 chr14 GO:0033554 Not Cancer Driver No 66 0.127 295 39 0.132 0
RNF111_ENST00000557998 RNF111 Q6ZNA4 E3 ubiquitin-protein ligase Arkadia chr15 GO:0033554 Not Cancer Driver No 111 0.112 855 96 0.112 0
RNF185 RNF185 Q96GF1 E3 ubiquitin-protein ligase RNF185 chr22 GO:0033554 Not Cancer Driver No 25 0.13 82 15 0.183 0
RNF186 RNF186 Q9NXI6 E3 ubiquitin-protein ligase RNF186 chr1 GO:0033554 Not Cancer Driver No 27 0.119 11 3 0.273 0
RNF34_ENST00000361234 RNF34 Q969K3 E3 ubiquitin-protein ligase RNF34 chr12 GO:0033554 Not Cancer Driver No 30 0.081 112 7 0.062 0
RNF5 RNF5 Q99942 E3 ubiquitin-protein ligase RNF5 chr6 GO:0033554 Not Cancer Driver No 17 0.094 69 3 0.043 0
ROMO1_ENST00000397416 ROMO1 P60602 Reactive oxygen species modulator 1 chr20 GO:0033554 Not Cancer Driver No 9 0.114 0 0 0.0 0
RPA2_ENST00000373912 RPA2 P15927 Replication protein A 32 kDa subunit chr1 GO:0033554 Not Cancer Driver No 28 0.104 114 16 0.14 0
RPL26 RPL26 P61254 60S ribosomal protein L26 chr17 GO:0033554 Not Cancer Driver No 16 0.11 114 13 0.114 0
RPS27L RPS27L Q71UM5 40S ribosomal protein S27-like chr15 GO:0033554 Not Cancer Driver No 4 0.048 22 2 0.091 0
RPS3_ENST00000527446 RPS3 P23396 40S ribosomal protein S3 chr11 GO:0033554 Not Cancer Driver No 22 0.091 48 4 0.083 0
RPS6KA1_ENST00000374168 RPS6KA1 Q15418 Ribosomal protein S6 kinase alpha-1 chr1 GO:0033554 Not Cancer Driver No 94 0.128 178 32 0.18 0
RPS6KA3_ENST00000379565 RPS6KA3 P51812 Ribosomal protein S6 kinase alpha-3 chrX GO:0033554 Compendium Yes 106 0.143 145 18 0.124 13
RPS6KA6_ENST00000262752 RPS6KA6 Q9UK32 Ribosomal protein S6 kinase alpha-6 chrX GO:0033554 Not Cancer Driver No 180 0.242 136 36 0.265 0
RRAGB RRAGB Q5VZM2 Ras-related GTP-binding protein B chrX GO:0033554 Not Cancer Driver No 67 0.179 37 5 0.135 0
RRAGD RRAGD Q9NQL2 Ras-related GTP-binding protein D chr6 GO:0033554 Not Cancer Driver No 42 0.105 83 5 0.06 0
RRP8 RRP8 O43159 Ribosomal RNA-processing protein 8 chr11 GO:0033554 Not Cancer Driver No 66 0.145 270 44 0.163 0
RTEL1_ENST00000370018 RTEL1 Q9NZ71 Regulator of telomere elongation helicase 1 chr20 GO:0033554 Not Cancer Driver No 144 0.118 474 64 0.135 14
RTN4RL1 RTN4RL1 Q86UN2 Reticulon-4 receptor-like 1 chr17 GO:0033554 Not Cancer Driver No 56 0.127 142 12 0.085 0
RTN4RL2 RTN4RL2 Q86UN3 Reticulon-4 receptor-like 2 chr11 GO:0033554 Not Cancer Driver No 38 0.09 121 5 0.041 0
SAXO1 SAXO1 Q8IYX7 Stabilizer of axonemal microtubules 1 chr9 GO:0033554 Not Cancer Driver No 63 0.133 249 35 0.141 0
SCAP SCAP Q12770 Sterol regulatory element-binding protein cleavage-activating protein chr3 GO:0033554 Not Cancer Driver No 145 0.113 329 36 0.109 0
SCN2A_ENST00000637266 SCN2A Q99250 Sodium channel protein type 2 subunit alpha chr2 GO:0033554 Not Cancer Driver No 502 0.25 435 133 0.306 65
SDE2 SDE2 Q6IQ49 Replication stress response regulator SDE2 chr1 GO:0033554 Not Cancer Driver No 56 0.124 290 35 0.121 0
SDF2L1 SDF2L1 Q9HCN8 Stromal cell-derived factor 2-like protein 1 chr22 GO:0033554 Not Cancer Driver No 16 0.072 130 9 0.069 0
SELENOK SELENOK Q9Y6D0 Selenoprotein K chr3 GO:0033554 Not Cancer Driver No 10 0.106 47 6 0.128 0
SELENOS SELENOS Q9BQE4 Selenoprotein S chr15 GO:0033554 Not Cancer Driver No 7 0.037 122 6 0.049 0
SESN1_ENST00000356644 SESN1 Q9Y6P5 Sestrin-1 chr6 GO:0033554 Not Cancer Driver No 45 0.091 48 4 0.083 0
SESN2 SESN2 P58004 Sestrin-2 chr1 GO:0033554 Not Cancer Driver No 74 0.154 147 26 0.177 0
SESN3 SESN3 P58005 Sestrin-3 chr11 GO:0033554 Not Cancer Driver No 84 0.171 44 4 0.091 0
SETX SETX Q7Z333 Probable helicase senataxin chr9 GO:0033554 Not Cancer Driver No 342 0.128 1240 156 0.126 20
SH3GLB1_ENST00000370558 SH3GLB1 Q9Y371 Endophilin-B1 chr1 GO:0033554 Not Cancer Driver No 41 0.112 82 10 0.122 0
SIK1 SIK1 P57059 Serine/threonine-protein kinase SIK1 chr21 GO:0033554 Not Cancer Driver No 80 0.102 330 30 0.091 3
SIK2 SIK2 Q9H0K1 Serine/threonine-protein kinase SIK2 chr11 GO:0033554 Not Cancer Driver No 94 0.102 525 56 0.107 0
SIN3A_ENST00000360439 SIN3A Q96ST3 Paired amphipathic helix protein Sin3a chr15 GO:0033554 Compendium Yes 172 0.135 617 73 0.118 0
SIPA1_ENST00000534313 SIPA1 Q96FS4 Signal-induced proliferation-associated protein 1 chr11 GO:0033554 Not Cancer Driver No 67 0.064 666 43 0.065 0
SIRPA_ENST00000400068 SIRPA P78324 Tyrosine-protein phosphatase non-receptor type substrate 1 chr20 GO:0033554 Census, Compendium Yes 96 0.19 281 51 0.181 0
SIRT1 SIRT1 Q96EB6 NAD-dependent protein deacetylase sirtuin-1 chr10 GO:0033554 Not Cancer Driver No 70 0.094 435 31 0.071 0
SIRT2 SIRT2 Q8IXJ6 NAD-dependent protein deacetylase sirtuin-2 chr19 GO:0033554 Not Cancer Driver No 56 0.144 85 17 0.2 0
SLC12A6_ENST00000558667 SLC12A6 Q9UHW9 Solute carrier family 12 member 6 chr15 GO:0033554 Not Cancer Driver No 168 0.146 280 46 0.164 0
SLC2A1 SLC2A1 P11166 Solute carrier family 2, facilitated glucose transporter member 1 chr1 GO:0033554 Not Cancer Driver No 51 0.104 13 2 0.154 48
SLC38A3 SLC38A3 Q99624 Sodium-coupled neutral amino acid transporter 3 chr3 GO:0033554 Not Cancer Driver No 61 0.121 42 2 0.048 0
SLC39A4 SLC39A4 Q6P5W5 Zinc transporter ZIP4 chr8 GO:0033554 Not Cancer Driver No 77 0.119 116 11 0.095 9
SLC39A5 SLC39A5 Q6ZMH5 Zinc transporter ZIP5 chr12 GO:0033554 Not Cancer Driver No 67 0.124 139 18 0.129 1
SLC4A11_ENST00000539553 SLC4A11 Q8NBS3 Solute carrier family 4 member 11 chr20 GO:0033554 Not Cancer Driver No 159 0.182 69 10 0.145 42
SLC9A1 SLC9A1 P19634 Sodium/hydrogen exchanger 1 chr1 GO:0033554 Not Cancer Driver No 89 0.109 251 29 0.116 1
SMC5 SMC5 Q8IY18 Structural maintenance of chromosomes protein 5 chr9 GO:0033554 Not Cancer Driver No 126 0.114 378 43 0.114 0
SMC6_ENST00000351948 SMC6 Q96SB8 Structural maintenance of chromosomes protein 6 chr2 GO:0033554 Not Cancer Driver No 128 0.117 458 57 0.124 0
SMPD3 SMPD3 Q9NY59 Sphingomyelin phosphodiesterase 3 chr16 GO:0033554 Not Cancer Driver No 92 0.14 224 29 0.129 0
SOCS5 SOCS5 O75159 Suppressor of cytokine signaling 5 chr2 GO:0033554 Not Cancer Driver No 84 0.157 297 46 0.155 0
SP100_ENST00000264052 SP100 P23497 Nuclear autoantigen Sp-100 chr2 GO:0033554 Not Cancer Driver No 136 0.155 680 101 0.149 0
SPHK1_ENST00000545180 SPHK1 Q9NYA1 Sphingosine kinase 1 chr17 GO:0033554 Not Cancer Driver No 47 0.122 25 2 0.08 0
SPI1_ENST00000378538 SPI1 P17947 Transcription factor PU.1 chr11 GO:0033554 Not Cancer Driver No 46 0.17 187 34 0.182 0
SPO11 SPO11 Q9Y5K1 Meiotic recombination protein SPO11 chr20 GO:0033554 Not Cancer Driver No 59 0.149 26 5 0.192 0
SPRTN SPRTN Q9H040 DNA-dependent metalloprotease SPRTN chr1 GO:0033554 Not Cancer Driver No 73 0.149 252 38 0.151 1
SQSTM1 SQSTM1 Q13501 Sequestosome-1 chr5 GO:0033554 Not Cancer Driver No 54 0.123 267 32 0.12 30
SRC_ENST00000358208 SRC P12931 Proto-oncogene tyrosine-protein kinase Src chr20 GO:0033554 Census Yes 53 0.099 130 11 0.085 1
SREBF1_ENST00000261646 SREBF1 P36956 Sterol regulatory element-binding protein 1 chr17 GO:0033554 Not Cancer Driver No 127 0.111 528 64 0.121 4
SREBF2 SREBF2 Q12772 Sterol regulatory element-binding protein 2 chr22 GO:0033554 Not Cancer Driver No 124 0.109 357 43 0.12 0
SRF SRF P11831 Serum response factor chr6 GO:0033554 Not Cancer Driver No 44 0.087 443 42 0.095 0
STAT6_ENST00000543873 STAT6 P42226 Signal transducer and activator of transcription 6 chr12 GO:0033554 Census, Compendium Yes 106 0.125 325 44 0.135 0
STK39 STK39 Q9UEW8 STE20/SPS1-related proline-alanine-rich protein kinase chr2 GO:0033554 Not Cancer Driver No 64 0.117 182 19 0.104 0
STOML2 STOML2 Q9UJZ1 Stomatin-like protein 2, mitochondrial chr9 GO:0033554 Not Cancer Driver No 40 0.112 117 9 0.077 0
STOX1_ENST00000399169 STOX1 Q6ZVD7 Storkhead-box protein 1 chr10 GO:0033554 Not Cancer Driver No 121 0.122 659 83 0.126 2
SUV39H1_ENST00000376687 SUV39H1 O43463 Histone-lysine N-methyltransferase SUV39H1 chrX GO:0033554 Not Cancer Driver No 59 0.143 15 1 0.067 0
SZT2_ENST00000634258 SZT2 Q5T011 KICSTOR complex protein SZT2 chr1 GO:0033554 Not Cancer Driver No 381 0.111 1292 161 0.125 1
TBL2 TBL2 Q9Y4P3 Transducin beta-like protein 2 chr7 GO:0033554 Not Cancer Driver No 68 0.152 115 13 0.113 0
TBX2 TBX2 Q13207 T-box transcription factor TBX2 chr17 GO:0033554 Not Cancer Driver No 74 0.104 401 36 0.09 1
TBX3 TBX3 O15119 T-box transcription factor TBX3 chr12 GO:0033554 Census, Compendium Yes 123 0.166 352 57 0.162 2
TCIM TCIM Q9NR00 Transcriptional and immune response regulator chr8 GO:0033554 Not Cancer Driver No 21 0.198 33 7 0.212 0
TDP1_ENST00000393454 TDP1 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 chr14 GO:0033554 Not Cancer Driver No 81 0.133 179 25 0.14 1
TERF2 TERF2 Q15554 Telomeric repeat-binding factor 2 chr16 GO:0033554 Not Cancer Driver No 33 0.061 361 20 0.055 0
TERF2IP TERF2IP Q9NYB0 Telomeric repeat-binding factor 2-interacting protein 1 chr16 GO:0033554 Not Cancer Driver No 28 0.07 310 16 0.052 0
TEX264_ENST00000416589 TEX264 Q9Y6I9 Testis-expressed protein 264 chr3 GO:0033554 Not Cancer Driver No 40 0.128 107 11 0.103 0
TFAP4 TFAP4 Q01664 Transcription factor AP-4 chr16 GO:0033554 Compendium Yes 61 0.18 285 52 0.182 0
TFIP11_ENST00000407148 TFIP11 Q9UBB9 Tuftelin-interacting protein 11 chr22 GO:0033554 Not Cancer Driver No 87 0.104 331 39 0.118 0
TFPI2 TFPI2 P48307 Tissue factor pathway inhibitor 2 chr7 GO:0033554 Not Cancer Driver No 54 0.23 5 11 2.2 0
THG1L THG1L Q9NWX6 Probable tRNA(His) guanylyltransferase chr5 GO:0033554 Not Cancer Driver No 32 0.107 22 2 0.091 1
TMBIM6_ENST00000549385 TMBIM6 P55061 Bax inhibitor 1 chr12 GO:0033554 Not Cancer Driver No 16 0.068 3 0 0.0 0
TMCO1 TMCO1 Q9UM00 Calcium load-activated calcium channel chr1 GO:0033554 Not Cancer Driver No 31 0.13 49 5 0.102 0
TMED2 TMED2 Q15363 Transmembrane emp24 domain-containing protein 2 chr12 GO:0033554 Not Cancer Driver No 24 0.119 25 4 0.16 0
TMEM117 TMEM117 Q9H0C3 Transmembrane protein 117 chr12 GO:0033554 Not Cancer Driver No 91 0.177 70 12 0.171 0
TNFAIP3 TNFAIP3 P21580 Tumor necrosis factor alpha-induced protein 3 chr6 GO:0033554 Census, Compendium Yes 98 0.124 231 33 0.143 1
TNFRSF10B TNFRSF10B O14763 Tumor necrosis factor receptor superfamily member 10B chr8 GO:0033554 Not Cancer Driver No 44 0.1 190 19 0.1 0
TNP1 TNP1 P09430 Spermatid nuclear transition protein 1 chr2 GO:0033554 Not Cancer Driver No 21 0.382 55 21 0.382 0
TOMM7 TOMM7 Q9P0U1 Mitochondrial import receptor subunit TOM7 homolog chr7 GO:0033554 Not Cancer Driver No 7 0.127 0 0 0.0 0
TOR1A TOR1A O14656 Torsin-1A chr9 GO:0033554 Not Cancer Driver No 33 0.099 0 0 0.0 3
TP53INP1 TP53INP1 Q96A56 Tumor protein p53-inducible nuclear protein 1 chr8 GO:0033554 Not Cancer Driver No 32 0.133 134 20 0.149 0
TP53_ENST00000445888 TP53 P04637 Cellular tumor antigen p53 chr17 GO:0033554 Census, Compendium Yes 2891 7.356 282 1466 5.199 83
TPM1_ENST00000403994 TPM1 P09493 Tropomyosin alpha-1 chain chr15 GO:0033554 Not Cancer Driver No 33 0.116 234 29 0.124 8
TPR TPR P12270 Nucleoprotein TPR chr1 GO:0033554 Census Yes 311 0.132 1990 266 0.134 0
TRAF2 TRAF2 Q12933 TNF receptor-associated factor 2 chr9 GO:0033554 Not Cancer Driver No 63 0.126 4 1 0.25 0
TRAIP TRAIP Q9BWF2 E3 ubiquitin-protein ligase TRAIP chr3 GO:0033554 Not Cancer Driver No 63 0.134 240 33 0.138 1
TREX1_ENST00000625293 TREX1 Q9NSU2 Three-prime repair exonuclease 1 chr3 GO:0033554 Not Cancer Driver No 26 0.083 98 10 0.102 18
TRIAP1 TRIAP1 O43715 TP53-regulated inhibitor of apoptosis 1 chr12 GO:0033554 Not Cancer Driver No 9 0.118 20 1 0.05 0
TRIB3_ENST00000217233 TRIB3 Q96RU7 Tribbles homolog 3 chr20 GO:0033554 Not Cancer Driver No 65 0.182 114 24 0.211 0
TRPA1 TRPA1 O75762 Transient receptor potential cation channel subfamily A member 1 chr8 GO:0033554 Not Cancer Driver No 324 0.29 62 14 0.226 1
TRPM2_ENST00000397928 TRPM2 O94759 Transient receptor potential cation channel subfamily M member 2 chr21 GO:0033554 Not Cancer Driver No 286 0.19 266 44 0.165 0
TRPV4 TRPV4 Q9HBA0 Transient receptor potential cation channel subfamily V member 4 chr12 GO:0033554 Not Cancer Driver No 142 0.163 231 34 0.147 44
TSPO_ENST00000329563 TSPO P30536 Translocator protein chr22 GO:0033554 Not Cancer Driver No 5 0.03 1 0 0.0 0
UBE2V2 UBE2V2 Q15819 Ubiquitin-conjugating enzyme E2 variant 2 chr8 GO:0033554 Not Cancer Driver No 22 0.152 76 12 0.158 0
UCP1 UCP1 P25874 Mitochondrial brown fat uncoupling protein 1 chr4 GO:0033554 Not Cancer Driver No 43 0.14 1 0 0.0 0
UFD1 UFD1 Q92890 Ubiquitin recognition factor in ER-associated degradation protein 1 chr22 GO:0033554 Not Cancer Driver No 26 0.085 100 7 0.07 0
UGGT1 UGGT1 Q9NYU2 UDP-glucose:glycoprotein glucosyltransferase 1 chr2 GO:0033554 Not Cancer Driver No 169 0.109 161 20 0.124 0
UGGT2 UGGT2 Q9NYU1 UDP-glucose:glycoprotein glucosyltransferase 2 chr13 GO:0033554 Not Cancer Driver No 190 0.125 64 6 0.094 0
ULK1 ULK1 O75385 Serine/threonine-protein kinase ULK1 chr12 GO:0033554 Not Cancer Driver No 142 0.135 588 77 0.131 0
ULK3 ULK3 Q6PHR2 Serine/threonine-protein kinase ULK3 chr15 GO:0033554 Not Cancer Driver No 37 0.078 55 2 0.036 0
UPP1_ENST00000395564 UPP1 Q16831 Uridine phosphorylase 1 chr7 GO:0033554 Not Cancer Driver No 47 0.152 13 3 0.231 0
USP10_ENST00000219473 USP10 Q14694 Ubiquitin carboxyl-terminal hydrolase 10 chr16 GO:0033554 Not Cancer Driver No 92 0.115 425 49 0.115 0
USP45 USP45 Q70EL2 Ubiquitin carboxyl-terminal hydrolase 45 chr6 GO:0033554 Not Cancer Driver No 96 0.118 275 28 0.102 0
USP7 USP7 Q93009 Ubiquitin carboxyl-terminal hydrolase 7 chr16 GO:0033554 Not Cancer Driver No 170 0.154 215 45 0.209 0
UVRAG UVRAG Q9P2Y5 UV radiation resistance-associated gene protein chr11 GO:0033554 Not Cancer Driver No 89 0.127 243 28 0.115 0
UVSSA UVSSA Q2YD98 UV-stimulated scaffold protein A chr4 GO:0033554 Not Cancer Driver No 101 0.142 519 70 0.135 1
VAPB VAPB O95292 Vesicle-associated membrane protein-associated protein B/C chr20 GO:0033554 Not Cancer Driver No 16 0.066 138 8 0.058 3
VCP VCP P55072 Transitional endoplasmic reticulum ATPase chr9 GO:0033554 Not Cancer Driver No 88 0.109 186 16 0.086 16
VCPIP1 VCPIP1 Q96JH7 Deubiquitinating protein VCPIP1 chr8 GO:0033554 Not Cancer Driver No 133 0.109 543 61 0.112 0
VEGFA_ENST00000523873 VEGFA P15692 Vascular endothelial growth factor A chr6 GO:0033554 Not Cancer Driver No 27 0.116 41 7 0.171 0
VHL VHL P40337 von Hippel-Lindau disease tumor suppressor chr3 GO:0033554 Census, Compendium Yes 142 0.667 117 36 0.308 133
WAC WAC Q9BTA9 WW domain-containing adapter protein with coiled-coil chr10 GO:0033554 Not Cancer Driver No 106 0.164 571 95 0.166 0
WFS1_ENST00000503569 WFS1 O76024 Wolframin chr4 GO:0033554 Not Cancer Driver No 105 0.118 203 10 0.049 39
WNK3_ENST00000375159 WNK3 Q9BYP7 Serine/threonine-protein kinase WNK3 chrX GO:0033554 Not Cancer Driver No 281 0.156 1281 200 0.156 0
WNT16 WNT16 Q9UBV4 Protein Wnt-16 chr7 GO:0033554 Not Cancer Driver No 59 0.162 28 9 0.321 0
XAB2 XAB2 Q9HCS7 Pre-mRNA-splicing factor SYF1 chr19 GO:0033554 Not Cancer Driver No 128 0.15 127 17 0.134 0
XBP1 XBP1 P17861 X-box-binding protein 1 chr22 GO:0033554 Not Cancer Driver No 19 0.073 169 9 0.053 0
XPA XPA P23025 DNA repair protein complementing XP-A cells chr9 GO:0033554 Census Yes 27 0.099 121 13 0.107 5
XPC XPC Q01831 DNA repair protein complementing XP-C cells chr3 GO:0033554 Census, Compendium Yes 88 0.094 479 48 0.1 2
XPR1 XPR1 Q9UBH6 Xenotropic and polytropic retrovirus receptor 1 chr1 GO:0033554 Not Cancer Driver No 103 0.148 70 15 0.214 4
XRCC1 XRCC1 P18887 DNA repair protein XRCC1 chr19 GO:0033554 Not Cancer Driver No 85 0.134 426 53 0.124 1
XRCC3_ENST00000352127 XRCC3 O43542 DNA repair protein XRCC3 chr14 GO:0033554 Not Cancer Driver No 24 0.069 35 2 0.057 1
XRCC5_ENST00000392132 XRCC5 P13010 X-ray repair cross-complementing protein 5 chr2 GO:0033554 Not Cancer Driver No 87 0.119 118 11 0.093 0
XRCC6 XRCC6 P12956 X-ray repair cross-complementing protein 6 chr22 GO:0033554 Not Cancer Driver No 66 0.108 140 12 0.086 0
YBX3 YBX3 P16989 Y-box-binding protein 3 chr12 GO:0033554 Not Cancer Driver No 49 0.132 359 47 0.131 0
ZBTB7A_ENST00000601588 ZBTB7A O95365 Zinc finger and BTB domain-containing protein 7A chr19 GO:0033554 Not Cancer Driver No 60 0.103 285 30 0.105 0
ZC3H12A ZC3H12A Q5D1E8 Endoribonuclease ZC3H12A chr1 GO:0033554 Not Cancer Driver No 90 0.15 396 44 0.111 0
ZFP36 ZFP36 P26651 mRNA decay activator protein ZFP36 chr19 GO:0033554 Not Cancer Driver No 43 0.132 262 34 0.13 0
ZFP36L1 ZFP36L1 Q07352 mRNA decay activator protein ZFP36L1 chr14 GO:0033554 Compendium Yes 57 0.169 212 30 0.142 0
ZNF277 ZNF277 Q9NRM2 Zinc finger protein 277 chr7 GO:0033554 Not Cancer Driver No 59 0.131 79 15 0.19 0
ZNF580_ENST00000545125 ZNF580 Q9UK33 Zinc finger protein 580 chr19 GO:0033554 Not Cancer Driver No 8 0.047 153 8 0.052 0