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Total number of protein in "GO:0031668" GO term:  131

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
ADNP ADNP Q9H2P0 Activity-dependent neuroprotector homeobox protein chr20 GO:0031668 Not Cancer Driver No 130 0.118 615 66 0.107 0
ADORA2B ADORA2B P29275 Adenosine receptor A2b chr17 GO:0031668 Not Cancer Driver No 23 0.069 0 0 0.0 0
AES_ENST00000327141 TLE5 Q08117 TLE family member 5 chr19 GO:0031668 Not Cancer Driver No 16 0.081 77 7 0.091 0
AIF1 AIF1 P55008 Allograft inflammatory factor 1 chr6 GO:0031668 Not Cancer Driver No 14 0.095 61 6 0.098 0
AIFM1 AIFM1 O95831 Apoptosis-inducing factor 1, mitochondrial chrX GO:0031668 Not Cancer Driver No 88 0.144 166 22 0.133 11
AOC1_ENST00000467291 AOC1 P19801 Amiloride-sensitive amine oxidase [copper-containing] chr7 GO:0031668 Not Cancer Driver No 161 0.214 98 26 0.265 0
AQP2 AQP2 P41181 Aquaporin-2 chr12 GO:0031668 Not Cancer Driver No 52 0.192 31 3 0.097 28
AQP3 AQP3 Q92482 Aquaporin-3 chr9 GO:0031668 Not Cancer Driver No 34 0.116 12 0 0.0 0
ARHGAP35_ENST00000614079 ARHGAP35 Q9NRY4 Rho GTPase-activating protein 35 chr19 GO:0031668 Census, Compendium Yes 255 0.17 409 58 0.142 0
ASGR1 ASGR1 P07306 Asialoglycoprotein receptor 1 chr17 GO:0031668 Not Cancer Driver No 23 0.079 95 5 0.053 0
ASNS_ENST00000394308 ASNS P08243 Asparagine synthetase [glutamine-hydrolyzing] chr7 GO:0031668 Not Cancer Driver No 81 0.144 11 0 0.0 3
ATF2 ATF2 P15336 Cyclic AMP-dependent transcription factor ATF-2 chr2 GO:0031668 Not Cancer Driver No 65 0.129 451 58 0.129 0
ATF4_ENST00000404241 ATF4 P18848 Cyclic AMP-dependent transcription factor ATF-4 chr22 GO:0031668 Not Cancer Driver No 53 0.151 259 38 0.147 0
ATG14 ATG14 Q6ZNE5 Beclin 1-associated autophagy-related key regulator chr14 GO:0031668 Not Cancer Driver No 48 0.098 209 24 0.115 0
ATG5_ENST00000343245 ATG5 Q9H1Y0 Autophagy protein 5 chr6 GO:0031668 Not Cancer Driver No 40 0.145 25 6 0.24 1
ATG7 ATG7 O95352 Ubiquitin-like modifier-activating enzyme ATG7 chr3 GO:0031668 Compendium Yes 77 0.11 53 8 0.151 6
ATP2B1_ENST00000261173 ATP2B1 P20020 Plasma membrane calcium-transporting ATPase 1 chr12 GO:0031668 Not Cancer Driver No 143 0.117 293 42 0.143 0
AVPR1A AVPR1A P37288 Vasopressin V1a receptor chr12 GO:0031668 Not Cancer Driver No 105 0.251 68 25 0.368 0
AXL AXL P30530 Tyrosine-protein kinase receptor UFO chr19 GO:0031668 Not Cancer Driver No 168 0.188 341 64 0.188 0
BCL2_ENST00000333681 BCL2 P10415 Apoptosis regulator Bcl-2 chr18 GO:0031668 Census, Compendium Yes 24 0.1 72 5 0.069 0
BECN1_ENST00000590099 BECN1 Q14457 Beclin-1 chr17 GO:0031668 Not Cancer Driver No 45 0.1 190 19 0.1 0
BGLAP BGLAP P02818 Osteocalcin chr1 GO:0031668 Not Cancer Driver No 13 0.13 21 2 0.095 0
BHLHA15 BHLHA15 Q7RTS1 Class A basic helix-loop-helix protein 15 chr7 GO:0031668 Not Cancer Driver No 12 0.063 183 12 0.066 0
BRIP1 BRIP1 Q9BX63 Fanconi anemia group J protein chr17 GO:0031668 Census Yes 174 0.139 397 59 0.149 6
BRSK1 BRSK1 Q8TDC3 Serine/threonine-protein kinase BRSK1 chr19 GO:0031668 Not Cancer Driver No 131 0.168 459 78 0.17 0
BRSK2_ENST00000528841 BRSK2 Q8IWQ3 Serine/threonine-protein kinase BRSK2 chr11 GO:0031668 Not Cancer Driver No 90 0.122 321 39 0.121 0
C12orf66_ENST00000398055 KICS2 Q96MD2 KICSTOR subunit 2 chr12 GO:0031668 Not Cancer Driver No 61 0.137 35 6 0.171 0
CASR_ENST00000638421 CASR P41180 Extracellular calcium-sensing receptor chr3 GO:0031668 Not Cancer Driver No 304 0.282 189 60 0.317 108
CBL CBL P22681 E3 ubiquitin-protein ligase CBL chr11 GO:0031668 Census, Compendium Yes 115 0.127 512 56 0.109 4
CBS_ENST00000359624 CBS P35520 Cystathionine beta-synthase chr21 GO:0031668 Not Cancer Driver No 61 0.111 160 19 0.119 103
CDKN1A_ENST00000373711 CDKN1A P38936 Cyclin-dependent kinase inhibitor 1 chr6 GO:0031668 Census, Compendium Yes 48 0.293 121 30 0.248 0
CDKN2B CDKN2B P42772 Cyclin-dependent kinase 4 inhibitor B chr9 GO:0031668 Not Cancer Driver No 15 0.109 67 3 0.045 0
COL1A1 COL1A1 P02452 Collagen alpha-1(I) chain chr17 GO:0031668 Census, Compendium Yes 247 0.169 1212 214 0.177 148
COMT COMT P21964 Catechol O-methyltransferase chr22 GO:0031668 Not Cancer Driver No 21 0.077 5 0 0.0 0
CPEB4 CPEB4 Q17RY0 Cytoplasmic polyadenylation element-binding protein 4 chr5 GO:0031668 Not Cancer Driver No 85 0.117 443 54 0.122 0
DCPS DCPS Q96C86 m7GpppX diphosphatase chr11 GO:0031668 Not Cancer Driver No 48 0.142 53 6 0.113 1
DCTPP1 DCTPP1 Q9H773 dCTP pyrophosphatase 1 chr16 GO:0031668 Not Cancer Driver No 14 0.082 88 9 0.102 0
EIF2AK3 EIF2AK3 Q9NZJ5 Eukaryotic translation initiation factor 2-alpha kinase 3 chr2 GO:0031668 Not Cancer Driver No 149 0.134 410 51 0.124 1
EIF2AK4 EIF2AK4 Q9P2K8 eIF-2-alpha kinase GCN2 chr15 GO:0031668 Not Cancer Driver No 156 0.095 494 44 0.089 2
ERCC6 ERCC6 Q03468 DNA excision repair protein ERCC-6 chr10 GO:0031668 Not Cancer Driver No 211 0.141 829 117 0.141 9
FES FES P07332 Tyrosine-protein kinase Fes/Fps chr15 GO:0031668 Census Yes 103 0.125 245 34 0.139 0
FGF23 FGF23 Q9GZV9 Fibroblast growth factor 23 chr12 GO:0031668 Not Cancer Driver No 84 0.335 97 51 0.526 7
FOLR1_ENST00000393681 FOLR1 P15328 Folate receptor alpha chr11 GO:0031668 Not Cancer Driver No 41 0.16 13 3 0.231 0
FOLR2 FOLR2 P14207 Folate receptor beta chr11 GO:0031668 Not Cancer Driver No 32 0.125 6 0 0.0 0
FOS FOS P01100 Protein c-Fos chr14 GO:0031668 Not Cancer Driver No 45 0.118 245 33 0.135 0
FOSL1 FOSL1 P15407 Fos-related antigen 1 chr11 GO:0031668 Not Cancer Driver No 24 0.089 271 24 0.089 0
FOXA2_ENST00000377115 FOXA2 Q9Y261 Hepatocyte nuclear factor 3-beta chr20 GO:0031668 Compendium Yes 70 0.153 258 34 0.132 0
FOXO3 FOXO3 O43524 Forkhead box protein O3 chr6 GO:0031668 Census, Compendium Yes 70 0.104 595 68 0.114 0
GABARAP GABARAP O95166 Gamma-aminobutyric acid receptor-associated protein chr17 GO:0031668 Not Cancer Driver No 9 0.077 11 0 0.0 0
GABARAPL1_ENST00000545887 GABARAPL1 Q9H0R8 Gamma-aminobutyric acid receptor-associated protein-like 1 chr12 GO:0031668 Not Cancer Driver No 19 0.162 10 1 0.1 0
GABARAPL2 GABARAPL2 P60520 Gamma-aminobutyric acid receptor-associated protein-like 2 chr16 GO:0031668 Not Cancer Driver No 11 0.094 2 1 0.5 0
GAS6 GAS6 Q14393 Growth arrest-specific protein 6 chr13 GO:0031668 Not Cancer Driver No 82 0.121 42 6 0.143 0
GCN1 GCN1 Q92616 eIF-2-alpha kinase activator GCN1 chr12 GO:0031668 Not Cancer Driver No 327 0.122 117 16 0.137 0
GDAP1 GDAP1 Q8TB36 Ganglioside-induced differentiation-associated protein 1 chr8 GO:0031668 Not Cancer Driver No 51 0.142 78 14 0.179 11
GLRX2_ENST00000367439 GLRX2 Q9NS18 Glutaredoxin-2, mitochondrial chr1 GO:0031668 Not Cancer Driver No 12 0.073 10 1 0.1 0
GSDMD_ENST00000262580 GSDMD P57764 Gasdermin-D chr8 GO:0031668 Not Cancer Driver No 47 0.097 156 16 0.103 0
HMOX1 HMOX1 P09601 Heme oxygenase 1 chr22 GO:0031668 Not Cancer Driver No 46 0.16 81 13 0.16 0
HNRNPA1 HNRNPA1 P09651 Heterogeneous nuclear ribonucleoprotein A1 chr12 GO:0031668 Not Cancer Driver No 70 0.188 290 58 0.2 4
HSPA5 HSPA5 P11021 Endoplasmic reticulum chaperone BiP chr9 GO:0031668 Not Cancer Driver No 73 0.112 282 35 0.124 0
IFI16_ENST00000295809 IFI16 Q16666 Gamma-interferon-inducible protein 16 chr1 GO:0031668 Not Cancer Driver No 155 0.197 419 90 0.215 0
IL15_ENST00000320650 IL15 P40933 Interleukin-15 chr4 GO:0031668 Not Cancer Driver No 25 0.154 6 1 0.167 0
IMPACT IMPACT Q9P2X3 Protein IMPACT chr18 GO:0031668 Not Cancer Driver No 49 0.153 84 12 0.143 0
ITFG2 ITFG2 Q969R8 KICSTOR complex protein ITFG2 chr12 GO:0031668 Not Cancer Driver No 59 0.132 61 9 0.148 0
KPTN KPTN Q9Y664 KICSTOR complex protein kaptin chr19 GO:0031668 Not Cancer Driver No 44 0.101 21 2 0.095 0
LARS LARS1 Q9P2J5 Leucine--tRNA ligase, cytoplasmic chr5 GO:0031668 Not Cancer Driver No 133 0.113 97 10 0.103 1
LEP LEP P41159 Leptin chr7 GO:0031668 Not Cancer Driver No 29 0.174 0 0 0.0 2
LPL LPL P06858 Lipoprotein lipase chr8 GO:0031668 Not Cancer Driver No 94 0.198 23 3 0.13 70
LYN LYN P07948 Tyrosine-protein kinase Lyn chr8 GO:0031668 Census Yes 95 0.186 84 12 0.143 0
MAP1LC3A_ENST00000397709 MAP1LC3A Q9H492 Microtubule-associated proteins 1A/1B light chain 3A chr20 GO:0031668 Not Cancer Driver No 22 0.182 24 1 0.042 0
MAP1LC3B MAP1LC3B Q9GZQ8 Microtubule-associated proteins 1A/1B light chain 3B chr16 GO:0031668 Not Cancer Driver No 10 0.08 17 1 0.059 0
MAP1LC3B2 MAP1LC3B2 A6NCE7 Microtubule-associated proteins 1A/1B light chain 3 beta 2 chr12 GO:0031668 Not Cancer Driver No 19 0.152 17 7 0.412 0
MAP1LC3C MAP1LC3C Q9BXW4 Microtubule-associated proteins 1A/1B light chain 3C chr1 GO:0031668 Not Cancer Driver No 32 0.218 31 5 0.161 0
MTMR3 MTMR3 Q13615 Myotubularin-related protein 3 chr22 GO:0031668 Not Cancer Driver No 130 0.109 501 66 0.132 0
MTOR MTOR P42345 Serine/threonine-protein kinase mTOR chr1 GO:0031668 Census, Compendium Yes 379 0.149 296 37 0.125 18
MYBBP1A_ENST00000254718 MYBBP1A Q9BQG0 Myb-binding protein 1A chr17 GO:0031668 Not Cancer Driver No 144 0.108 463 47 0.102 0
NCOA1_ENST00000348332 NCOA1 Q15788 Nuclear receptor coactivator 1 chr2 GO:0031668 Census, Compendium Yes 188 0.13 1217 149 0.122 0
NDOR1_ENST00000344894 NDOR1 Q9UHB4 NADPH-dependent diflavin oxidoreductase 1 chr9 GO:0031668 Not Cancer Driver No 60 0.101 67 7 0.104 0
NFE2L2 NFE2L2 Q16236 Nuclear factor erythroid 2-related factor 2 chr2 GO:0031668 Census, Compendium Yes 228 0.377 402 62 0.154 4
NIM1K NIM1K Q8IY84 Serine/threonine-protein kinase NIM1 chr5 GO:0031668 Not Cancer Driver No 73 0.167 126 21 0.167 0
NR1H4 NR1H4 Q96RI1 Bile acid receptor chr12 GO:0031668 Not Cancer Driver No 111 0.228 78 18 0.231 0
NR4A2_ENST00000409572 NR4A2 P43354 Nuclear receptor subfamily 4 group A member 2 chr2 GO:0031668 Not Cancer Driver No 110 0.184 261 38 0.146 0
NUAK1 NUAK1 O60285 NUAK family SNF1-like kinase 1 chr12 GO:0031668 Not Cancer Driver No 142 0.215 357 77 0.216 0
NUDT15 NUDT15 Q9NV35 Nucleotide triphosphate diphosphatase NUDT15 chr13 GO:0031668 Not Cancer Driver No 24 0.146 37 3 0.081 0
NUDT1_ENST00000397046 NUDT1 P36639 Oxidized purine nucleoside triphosphate hydrolase chr7 GO:0031668 Not Cancer Driver No 25 0.16 17 4 0.235 0
P2RX7 P2RX7 Q99572 P2X purinoceptor 7 chr12 GO:0031668 Not Cancer Driver No 51 0.086 14 2 0.143 0
PCK1 PCK1 P35558 Phosphoenolpyruvate carboxykinase, cytosolic [GTP] chr20 GO:0031668 Not Cancer Driver No 142 0.228 110 28 0.255 1
PDK2 PDK2 Q15119 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial chr17 GO:0031668 Not Cancer Driver No 45 0.111 35 4 0.114 0
PENK_ENST00000451791 PENK P01210 Proenkephalin-A chr8 GO:0031668 Not Cancer Driver No 109 0.408 142 62 0.437 0
PHEX PHEX P78562 Phosphate-regulating neutral endopeptidase PHEX chrX GO:0031668 Not Cancer Driver No 144 0.192 56 7 0.125 30
PICK1 PICK1 Q9NRD5 PRKCA-binding protein chr22 GO:0031668 Not Cancer Driver No 50 0.12 49 3 0.061 0
PIK3C3 PIK3C3 Q8NEB9 Phosphatidylinositol 3-kinase catalytic subunit type 3 chr18 GO:0031668 Not Cancer Driver No 127 0.143 191 34 0.178 0
PIK3R4 PIK3R4 Q99570 Phosphoinositide 3-kinase regulatory subunit 4 chr3 GO:0031668 Not Cancer Driver No 193 0.142 315 45 0.143 0
PLEC PLEC Q15149 Plectin chr8 GO:0031668 Not Cancer Driver No 677 0.145 2130 272 0.128 2
PMAIP1 PMAIP1 Q13794 Phorbol-12-myristate-13-acetate-induced protein 1 chr18 GO:0031668 Not Cancer Driver No 2 0.037 23 1 0.043 0
POSTN POSTN Q15063 Periostin chr13 GO:0031668 Not Cancer Driver No 204 0.244 86 27 0.314 0
PRKAA1_ENST00000397128 PRKAA1 Q13131 5'-AMP-activated protein kinase catalytic subunit alpha-1 chr5 GO:0031668 Not Cancer Driver No 72 0.129 124 17 0.137 0
PRKAA2 PRKAA2 P54646 5'-AMP-activated protein kinase catalytic subunit alpha-2 chr1 GO:0031668 Not Cancer Driver No 128 0.232 98 26 0.265 0
PRKAG1_ENST00000548065 PRKAG1 P54619 5'-AMP-activated protein kinase subunit gamma-1 chr12 GO:0031668 Not Cancer Driver No 35 0.106 25 2 0.08 0
PRKAG2 PRKAG2 Q9UGJ0 5'-AMP-activated protein kinase subunit gamma-2 chr7 GO:0031668 Not Cancer Driver No 76 0.134 240 45 0.188 7
PRKAG3_ENST00000529249 PRKAG3 Q9UGI9 5'-AMP-activated protein kinase subunit gamma-3 chr2 GO:0031668 Not Cancer Driver No 74 0.151 144 25 0.174 0
PTPRC PTPRC P08575 Receptor-type tyrosine-protein phosphatase C chr1 GO:0031668 Census, Compendium Yes 315 0.241 462 107 0.232 0
RRAGB RRAGB Q5VZM2 Ras-related GTP-binding protein B chrX GO:0031668 Not Cancer Driver No 67 0.179 37 5 0.135 0
RRAGD RRAGD Q9NQL2 Ras-related GTP-binding protein D chr6 GO:0031668 Not Cancer Driver No 42 0.105 83 5 0.06 0
RRP8 RRP8 O43159 Ribosomal RNA-processing protein 8 chr11 GO:0031668 Not Cancer Driver No 66 0.145 270 44 0.163 0
SESN1_ENST00000356644 SESN1 Q9Y6P5 Sestrin-1 chr6 GO:0031668 Not Cancer Driver No 45 0.091 48 4 0.083 0
SESN2 SESN2 P58004 Sestrin-2 chr1 GO:0031668 Not Cancer Driver No 74 0.154 147 26 0.177 0
SESN3 SESN3 P58005 Sestrin-3 chr11 GO:0031668 Not Cancer Driver No 84 0.171 44 4 0.091 0
SFRP1 SFRP1 Q8N474 Secreted frizzled-related protein 1 chr8 GO:0031668 Not Cancer Driver No 40 0.127 39 7 0.179 0
SFRP2 SFRP2 Q96HF1 Secreted frizzled-related protein 2 chr4 GO:0031668 Not Cancer Driver No 47 0.159 1 0 0.0 0
SH3GLB1_ENST00000370558 SH3GLB1 Q9Y371 Endophilin-B1 chr1 GO:0031668 Not Cancer Driver No 41 0.112 82 10 0.122 0
SIK1 SIK1 P57059 Serine/threonine-protein kinase SIK1 chr21 GO:0031668 Not Cancer Driver No 80 0.102 330 30 0.091 3
SIK2 SIK2 Q9H0K1 Serine/threonine-protein kinase SIK2 chr11 GO:0031668 Not Cancer Driver No 94 0.102 525 56 0.107 0
SIPA1_ENST00000534313 SIPA1 Q96FS4 Signal-induced proliferation-associated protein 1 chr11 GO:0031668 Not Cancer Driver No 67 0.064 666 43 0.065 0
SIRT1 SIRT1 Q96EB6 NAD-dependent protein deacetylase sirtuin-1 chr10 GO:0031668 Not Cancer Driver No 70 0.094 435 31 0.071 0
SLC1A2 SLC1A2 P43004 Excitatory amino acid transporter 2 chr11 GO:0031668 Not Cancer Driver No 77 0.134 81 7 0.086 3
SLC2A1 SLC2A1 P11166 Solute carrier family 2, facilitated glucose transporter member 1 chr1 GO:0031668 Not Cancer Driver No 51 0.104 13 2 0.154 48
SLC38A3 SLC38A3 Q99624 Sodium-coupled neutral amino acid transporter 3 chr3 GO:0031668 Not Cancer Driver No 61 0.121 42 2 0.048 0
SLC39A4 SLC39A4 Q6P5W5 Zinc transporter ZIP4 chr8 GO:0031668 Not Cancer Driver No 77 0.119 116 11 0.095 9
SLC39A5 SLC39A5 Q6ZMH5 Zinc transporter ZIP5 chr12 GO:0031668 Not Cancer Driver No 67 0.124 139 18 0.129 1
SRF SRF P11831 Serum response factor chr6 GO:0031668 Not Cancer Driver No 44 0.087 443 42 0.095 0
SUV39H1_ENST00000376687 SUV39H1 O43463 Histone-lysine N-methyltransferase SUV39H1 chrX GO:0031668 Not Cancer Driver No 59 0.143 15 1 0.067 0
SZT2_ENST00000634258 SZT2 Q5T011 KICSTOR complex protein SZT2 chr1 GO:0031668 Not Cancer Driver No 381 0.111 1292 161 0.125 1
TBL2 TBL2 Q9Y4P3 Transducin beta-like protein 2 chr7 GO:0031668 Not Cancer Driver No 68 0.152 115 13 0.113 0
TP53_ENST00000445888 TP53 P04637 Cellular tumor antigen p53 chr17 GO:0031668 Census, Compendium Yes 2891 7.356 282 1466 5.199 83
TSC1 TSC1 Q92574 Hamartin chr9 GO:0031668 Census, Compendium Yes 135 0.116 732 78 0.107 11
UPP1_ENST00000395564 UPP1 Q16831 Uridine phosphorylase 1 chr7 GO:0031668 Not Cancer Driver No 47 0.152 13 3 0.231 0
USF1 USF1 P22415 Upstream stimulatory factor 1 chr1 GO:0031668 Not Cancer Driver No 52 0.168 271 44 0.162 0
USF2 USF2 Q15853 Upstream stimulatory factor 2 chr19 GO:0031668 Not Cancer Driver No 30 0.087 326 29 0.089 0
XBP1 XBP1 P17861 X-box-binding protein 1 chr22 GO:0031668 Not Cancer Driver No 19 0.073 169 9 0.053 0
XPR1 XPR1 Q9UBH6 Xenotropic and polytropic retrovirus receptor 1 chr1 GO:0031668 Not Cancer Driver No 103 0.148 70 15 0.214 4
ZC3H12A ZC3H12A Q5D1E8 Endoribonuclease ZC3H12A chr1 GO:0031668 Not Cancer Driver No 90 0.15 396 44 0.111 0