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Total number of protein in "GO:0031334" GO term:  136

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
ABCA1 ABCA1 O95477 Phospholipid-transporting ATPase ABCA1 chr9 GO:0031334 Not Cancer Driver No 284 0.126 245 40 0.163 31
ABCA3 ABCA3 Q99758 Phospholipid-transporting ATPase ABCA3 chr16 GO:0031334 Not Cancer Driver No 224 0.131 77 4 0.052 13
AJUBA AJUBA Q96IF1 LIM domain-containing protein ajuba chr14 GO:0031334 Compendium Yes 45 0.084 307 13 0.042 0
AKAP9 AKAP9 Q99996 A-kinase anchor protein 9 chr7 GO:0031334 Census Yes 474 0.121 2281 268 0.117 1
AMBRA1_ENST00000458649 AMBRA1 Q9C0C7 Activating molecule in BECN1-regulated autophagy protein 1 chr11 GO:0031334 Not Cancer Driver No 173 0.133 788 103 0.131 0
ANKRD53 ANKRD53 Q8N9V6 Ankyrin repeat domain-containing protein 53 chr2 GO:0031334 Not Cancer Driver No 57 0.108 252 21 0.083 0
ARHGEF5 ARHGEF5 Q12774 Rho guanine nucleotide exchange factor 5 chr7 GO:0031334 Not Cancer Driver No 170 0.106 1141 127 0.111 0
ARL2 ARL2 P36404 ADP-ribosylation factor-like protein 2 chr11 GO:0031334 Not Cancer Driver No 19 0.103 0 0 0.0 1
ARL3 ARL3 P36405 ADP-ribosylation factor-like protein 3 chr10 GO:0031334 Not Cancer Driver No 16 0.088 0 0 0.0 2
ASAP1 ASAP1 Q9ULH1 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 chr8 GO:0031334 Not Cancer Driver No 183 0.162 584 108 0.185 0
ATAT1_ENST00000376485 ATAT1 Q5SQI0 Alpha-tubulin N-acetyltransferase 1 chr6 GO:0031334 Not Cancer Driver No 31 0.074 271 20 0.074 0
ATM_ENST00000452508 ATM Q13315 Serine-protein kinase ATM chr11 GO:0031334 Census, Compendium Yes 469 0.153 225 39 0.173 41
ATR ATR Q13535 Serine/threonine-protein kinase ATR chr3 GO:0031334 Census, Compendium Yes 338 0.128 106 14 0.132 1
BAK1 BAK1 Q16611 Bcl-2 homologous antagonist/killer chr6 GO:0031334 Not Cancer Driver No 38 0.18 58 9 0.155 0
BAX_ENST00000345358 BAX Q07812 Apoptosis regulator BAX chr19 GO:0031334 Census Yes 30 0.156 39 2 0.051 0
BCL2L11 BCL2L11 O43521 Bcl-2-like protein 11 chr2 GO:0031334 Not Cancer Driver No 42 0.212 130 17 0.131 0
BID_ENST00000551952 BID P55957 BH3-interacting domain death agonist chr22 GO:0031334 Not Cancer Driver No 23 0.118 74 9 0.122 0
BIK BIK Q13323 Bcl-2-interacting killer chr22 GO:0031334 Not Cancer Driver No 16 0.1 21 4 0.19 0
BMF_ENST00000561360 BMF Q96LC9 Bcl-2-modifying factor chr15 GO:0031334 Not Cancer Driver No 22 0.12 94 9 0.096 0
BRK1 BRK1 Q8WUW1 Protein BRICK1 chr3 GO:0031334 Not Cancer Driver No 7 0.093 14 1 0.071 0
CALY CALY Q9NYX4 Neuron-specific vesicular protein calcyon chr10 GO:0031334 Not Cancer Driver No 8 0.037 133 5 0.038 0
CAPG_ENST00000409724 CAPG P40121 Macrophage-capping protein chr2 GO:0031334 Not Cancer Driver No 45 0.129 95 7 0.074 0
CARMIL1 CARMIL1 Q5VZK9 F-actin-uncapping protein LRRC16A chr6 GO:0031334 Not Cancer Driver No 171 0.125 537 87 0.162 0
CARMIL2 CARMIL2 Q6F5E8 Capping protein, Arp2/3 and myosin-I linker protein 2 chr16 GO:0031334 Not Cancer Driver No 154 0.107 669 75 0.112 4
CAV3 CAV3 P56539 Caveolin-3 chr3 GO:0031334 Not Cancer Driver No 27 0.179 0 0 0.0 25
CD36_ENST00000309881 CD36 P16671 Platelet glycoprotein 4 chr7 GO:0031334 Not Cancer Driver No 75 0.159 12 3 0.25 3
CDC42EP2 CDC42EP2 O14613 Cdc42 effector protein 2 chr11 GO:0031334 Not Cancer Driver No 19 0.09 162 17 0.105 0
CDH17 CDH17 Q12864 Cadherin-17 chr8 GO:0031334 Census Yes 166 0.2 186 35 0.188 0
CDH5 CDH5 P33151 Cadherin-5 chr16 GO:0031334 Not Cancer Driver No 144 0.184 305 55 0.18 0
CDK5R1 CDK5R1 Q15078 Cyclin-dependent kinase 5 activator 1 chr17 GO:0031334 Not Cancer Driver No 35 0.114 103 16 0.155 0
CDK5RAP2 CDK5RAP2 Q96SN8 CDK5 regulatory subunit-associated protein 2 chr9 GO:0031334 Not Cancer Driver No 217 0.115 1136 128 0.113 0
CDKN1B CDKN1B P46527 Cyclin-dependent kinase inhibitor 1B chr12 GO:0031334 Census, Compendium Yes 19 0.096 198 19 0.096 0
CDT1 CDT1 Q9H211 DNA replication factor Cdt1 chr16 GO:0031334 Not Cancer Driver No 60 0.11 377 35 0.093 5
CKAP5 CKAP5 Q14008 Cytoskeleton-associated protein 5 chr11 GO:0031334 Not Cancer Driver No 198 0.097 634 64 0.101 0
CLASP1_ENST00000646274 CLASP1 Q7Z460 CLIP-associating protein 1 chr2 GO:0031334 Not Cancer Driver No 163 0.106 642 70 0.109 0
CLEC7A CLEC7A Q9BXN2 C-type lectin domain family 7 member A chr12 GO:0031334 Not Cancer Driver No 43 0.174 46 2 0.043 0
CLIP1 CLIP1 P30622 CAP-Gly domain-containing linker protein 1 chr12 GO:0031334 Census, Compendium Yes 184 0.128 1194 136 0.114 0
CLU_ENST00000523500 CLU P10909 Clusterin chr8 GO:0031334 Not Cancer Driver No 69 0.154 156 27 0.173 0
CRBN CRBN Q96SW2 Protein cereblon chr3 GO:0031334 Not Cancer Driver No 52 0.118 76 10 0.132 1
CSF2 CSF2 P04141 Granulocyte-macrophage colony-stimulating factor chr5 GO:0031334 Not Cancer Driver No 11 0.076 34 3 0.088 0
CXCL13 CXCL13 O43927 C-X-C motif chemokine 13 chr4 GO:0031334 Not Cancer Driver No 11 0.101 0 0 0.0 0
DAB2IP_ENST00000408936 DAB2IP Q5VWQ8 Disabled homolog 2-interacting protein chr9 GO:0031334 Not Cancer Driver No 131 0.11 681 68 0.1 0
DCTN1 DCTN1 Q14203 Dynactin subunit 1 chr2 GO:0031334 Census Yes 172 0.135 817 111 0.136 11
DDX3X_ENST00000629496 DDX3X O00571 ATP-dependent RNA helicase DDX3X chrX GO:0031334 Census, Compendium Yes 133 0.201 301 47 0.156 18
DHX33 DHX33 Q9H6R0 ATP-dependent RNA helicase DHX33 chr17 GO:0031334 Not Cancer Driver No 53 0.075 125 12 0.096 0
DRG1 DRG1 Q9Y295 Developmentally-regulated GTP-binding protein 1 chr22 GO:0031334 Not Cancer Driver No 35 0.095 31 0 0.0 0
EIF4G1_ENST00000346169 EIF4G1 Q04637 Eukaryotic translation initiation factor 4 gamma 1 chr3 GO:0031334 Not Cancer Driver No 229 0.143 1079 153 0.142 2
FAF1 FAF1 Q9UNN5 FAS-associated factor 1 chr1 GO:0031334 Not Cancer Driver No 83 0.128 241 34 0.141 0
FERMT1 FERMT1 Q9BQL6 Fermitin family homolog 1 chr20 GO:0031334 Not Cancer Driver No 100 0.148 65 8 0.123 2
FERMT2_ENST00000395631 FERMT2 Q96AC1 Fermitin family homolog 2 chr14 GO:0031334 Not Cancer Driver No 71 0.104 101 10 0.099 0
FES FES P07332 Tyrosine-protein kinase Fes/Fps chr15 GO:0031334 Census Yes 103 0.125 245 34 0.139 0
FNIP1 FNIP1 Q8TF40 Folliculin-interacting protein 1 chr5 GO:0031334 Not Cancer Driver No 143 0.123 384 44 0.115 0
FNIP2 FNIP2 Q9P278 Folliculin-interacting protein 2 chr4 GO:0031334 Not Cancer Driver No 119 0.107 555 71 0.128 0
FSCN1 FSCN1 Q16658 Fascin chr7 GO:0031334 Not Cancer Driver No 58 0.118 81 5 0.062 0
GBP5 GBP5 Q96PP8 Guanylate-binding protein 5 chr1 GO:0031334 Not Cancer Driver No 106 0.181 170 21 0.124 0
GIT1_ENST00000225394 GIT1 Q9Y2X7 ARF GTPase-activating protein GIT1 chr17 GO:0031334 Not Cancer Driver No 67 0.088 434 42 0.097 0
GNL3L_ENST00000360845 GNL3L Q9NVN8 Guanine nucleotide-binding protein-like 3-like protein chrX GO:0031334 Not Cancer Driver No 120 0.206 242 43 0.178 0
GSK3B_ENST00000264235 GSK3B P49841 Glycogen synthase kinase-3 beta chr3 GO:0031334 Not Cancer Driver No 56 0.133 146 13 0.089 0
HIP1R HIP1R O75146 Huntingtin-interacting protein 1-related protein chr12 GO:0031334 Not Cancer Driver No 94 0.088 524 34 0.065 0
HSPA1A HSPA1A P0DMV8 Heat shock 70 kDa protein 1A chr6 GO:0031334 Not Cancer Driver No 24 0.037 200 13 0.065 0
HSPA1B HSPA1B P0DMV9 Heat shock 70 kDa protein 1B chr6 GO:0031334 Not Cancer Driver No 15 0.023 200 5 0.025 0
ICE1 ICE1 Q9Y2F5 Little elongation complex subunit 1 chr5 GO:0031334 Not Cancer Driver No 360 0.159 1666 265 0.159 0
IFNG IFNG P01579 Interferon gamma chr12 GO:0031334 Not Cancer Driver No 51 0.307 23 6 0.261 0
IL5 IL5 P05113 Interleukin-5 chr5 GO:0031334 Not Cancer Driver No 13 0.097 0 0 0.0 0
ISG15 ISG15 P05161 Ubiquitin-like protein ISG15 chr1 GO:0031334 Not Cancer Driver No 12 0.073 24 2 0.083 0
KIAA1211 CRACD Q6ZU35 Capping protein-inhibiting regulator of actin dynamics chr4 GO:0031334 Not Cancer Driver No 245 0.199 1210 241 0.199 0
LCP1 LCP1 P13796 Plastin-2 chr13 GO:0031334 Census Yes 99 0.158 73 11 0.151 0
LGALS3 LGALS3 P17931 Galectin-3 chr14 GO:0031334 Not Cancer Driver No 15 0.06 133 6 0.045 0
MAP1B MAP1B P46821 Microtubule-associated protein 1B chr5 GO:0031334 Not Cancer Driver No 332 0.135 1947 278 0.143 0
MAPK9 MAPK9 P45984 Mitogen-activated protein kinase 9 chr5 GO:0031334 Not Cancer Driver No 59 0.139 90 8 0.089 0
MAPRE1 MAPRE1 Q15691 Microtubule-associated protein RP/EB family member 1 chr20 GO:0031334 Not Cancer Driver No 26 0.097 109 11 0.101 0
MAPT_ENST00000262410 MAPT P10636 Microtubule-associated protein tau chr17 GO:0031334 Not Cancer Driver No 128 0.169 750 126 0.168 18
MECP2_ENST00000303391 MECP2 P51608 Methyl-CpG-binding protein 2 chrX GO:0031334 Not Cancer Driver No 75 0.154 483 74 0.153 46
MED25 MED25 Q71SY5 Mediator of RNA polymerase II transcription subunit 25 chr19 GO:0031334 Not Cancer Driver No 103 0.138 432 54 0.125 2
MET_ENST00000397752 MET P08581 Hepatocyte growth factor receptor chr7 GO:0031334 Census, Compendium Yes 226 0.163 62 15 0.242 19
MMP1 MMP1 P03956 Interstitial collagenase chr11 GO:0031334 Not Cancer Driver No 83 0.177 113 18 0.159 0
MMP3 MMP3 P08254 Stromelysin-1 chr11 GO:0031334 Not Cancer Driver No 99 0.208 66 14 0.212 0
MPP7 MPP7 Q5T2T1 MAGUK p55 subfamily member 7 chr10 GO:0031334 Not Cancer Driver No 132 0.229 199 72 0.362 0
MSN MSN P26038 Moesin chrX GO:0031334 Census, Compendium Yes 108 0.187 286 56 0.196 1
MYD88_ENST00000396334 MYD88 Q99836 Myeloid differentiation primary response protein MyD88 chr3 GO:0031334 Census, Compendium Yes 37 0.125 47 1 0.021 2
NAV3 NAV3 Q8IVL0 Neuron navigator 3 chr12 GO:0031334 Not Cancer Driver No 699 0.293 1823 548 0.301 0
NEK7 NEK7 Q8TDX7 Serine/threonine-protein kinase Nek7 chr1 GO:0031334 Not Cancer Driver No 35 0.116 23 0 0.0 0
NIN NIN Q8N4C6 Ninein chr14 GO:0031334 Census, Compendium Yes 239 0.114 1392 164 0.118 2
NR1H2_ENST00000593926 NR1H2 P55055 Oxysterols receptor LXR-beta chr19 GO:0031334 Not Cancer Driver No 56 0.122 179 30 0.168 0
NRG1_ENST00000405005 NRG1 Q02297 Pro-neuregulin-1, membrane-bound isoform chr8 GO:0031334 Census, Compendium Yes 159 0.248 528 132 0.25 0
NUMA1 NUMA1 Q14980 Nuclear mitotic apparatus protein 1 chr11 GO:0031334 Census, Compendium Yes 234 0.111 1864 203 0.109 0
OCLN OCLN Q16625 Occludin chr5 GO:0031334 Not Cancer Driver No 54 0.103 244 21 0.086 1
P2RY12 P2RY12 Q9H244 P2Y purinoceptor 12 chr3 GO:0031334 Not Cancer Driver No 57 0.167 21 2 0.095 3
PAK1_ENST00000356341 PAK1 Q13153 Serine/threonine-protein kinase PAK 1 chr11 GO:0031334 Not Cancer Driver No 57 0.105 299 30 0.1 2
PARK7_ENST00000377488 PARK7 Q99497 Parkinson disease protein 7 chr1 GO:0031334 Not Cancer Driver No 11 0.058 30 0 0.0 5
PIEZO1 PIEZO1 Q92508 Piezo-type mechanosensitive ion channel component 1 chr16 GO:0031334 Not Cancer Driver No 122 0.048 471 26 0.055 12
PIH1D1 PIH1D1 Q9NWS0 PIH1 domain-containing protein 1 chr19 GO:0031334 Not Cancer Driver No 30 0.103 157 13 0.083 0
PINK1 PINK1 Q9BXM7 Serine/threonine-protein kinase PINK1, mitochondrial chr1 GO:0031334 Not Cancer Driver No 57 0.098 99 13 0.131 23
PLCG2 PLCG2 P16885 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 chr16 GO:0031334 Not Cancer Driver No 248 0.196 142 30 0.211 1
PLEK PLEK P08567 Pleckstrin chr2 GO:0031334 Not Cancer Driver No 81 0.231 39 9 0.231 0
PPP2R5B PPP2R5B Q15173 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform chr11 GO:0031334 Not Cancer Driver No 79 0.159 119 9 0.076 0
PSRC1_ENST00000409138 PSRC1 Q6PGN9 Proline/serine-rich coiled-coil protein 1 chr1 GO:0031334 Not Cancer Driver No 30 0.083 361 30 0.083 0
RAC1_ENST00000348035 RAC1 P63000 Ras-related C3 botulinum toxin substrate 1 chr7 GO:0031334 Census, Compendium Yes 66 0.344 2 1 0.5 6
RACK1 RACK1 P63244 Receptor of activated protein C kinase 1 chr5 GO:0031334 Not Cancer Driver No 34 0.107 13 0 0.0 0
RAP1B_ENST00000393436 RAP1B P61224 Ras-related protein Rap-1b chr12 GO:0031334 Not Cancer Driver No 26 0.141 14 3 0.214 0
RASIP1 RASIP1 Q5U651 Ras-interacting protein 1 chr19 GO:0031334 Not Cancer Driver No 73 0.076 505 48 0.095 0
RHOA RHOA P61586 Transforming protein RhoA chr3 GO:0031334 Census, Compendium Yes 99 0.513 46 13 0.283 2
RHOC_ENST00000369642 RHOC P08134 Rho-related GTP-binding protein RhoC chr1 GO:0031334 Not Cancer Driver No 30 0.155 53 7 0.132 0
RPS3_ENST00000527446 RPS3 P23396 40S ribosomal protein S3 chr11 GO:0031334 Not Cancer Driver No 22 0.091 48 4 0.083 0
SH3GLB1_ENST00000370558 SH3GLB1 Q9Y371 Endophilin-B1 chr1 GO:0031334 Not Cancer Driver No 41 0.112 82 10 0.122 0
SKAP1_ENST00000584924 SKAP1 Q86WV1 Src kinase-associated phosphoprotein 1 chr17 GO:0031334 Not Cancer Driver No 67 0.187 130 27 0.208 0
SLAIN1_ENST00000466548 SLAIN1 Q8ND83 SLAIN motif-containing protein 1 chr13 GO:0031334 Not Cancer Driver No 62 0.109 485 58 0.12 0
SLAIN2 SLAIN2 Q9P270 SLAIN motif-containing protein 2 chr4 GO:0031334 Not Cancer Driver No 62 0.107 562 60 0.107 0
SLF1 SLF1 Q9BQI6 SMC5-SMC6 complex localization factor protein 1 chr5 GO:0031334 Not Cancer Driver No 104 0.098 167 12 0.072 0
SLF2_ENST00000238961 SLF2 Q8IX21 SMC5-SMC6 complex localization factor protein 2 chr10 GO:0031334 Not Cancer Driver No 112 0.095 725 76 0.105 0
SNCA_ENST00000506244 SNCA P37840 Alpha-synuclein chr4 GO:0031334 Not Cancer Driver No 21 0.15 107 13 0.121 5
SPIDR SPIDR Q14159 DNA repair-scaffolding protein chr8 GO:0031334 Not Cancer Driver No 101 0.11 329 20 0.061 0
SRC_ENST00000358208 SRC P12931 Proto-oncogene tyrosine-protein kinase Src chr20 GO:0031334 Census Yes 53 0.099 130 11 0.085 1
STMP1 STMP1 E0CX11 Short transmembrane mitochondrial protein 1 chr7 GO:0031334 Not Cancer Driver No 1 0.021 12 0 0.0 0
STUB1 STUB1 Q9UNE7 E3 ubiquitin-protein ligase CHIP chr16 GO:0031334 Not Cancer Driver No 35 0.116 112 14 0.125 12
SUMO1_ENST00000392245 SUMO1 P63165 Small ubiquitin-related modifier 1 chr2 GO:0031334 Not Cancer Driver No 10 0.099 76 7 0.092 0
SYK_ENST00000375746 SYK P43405 Tyrosine-protein kinase SYK chr9 GO:0031334 Census Yes 96 0.151 131 27 0.206 5
TAL1 TAL1 P17542 T-cell acute lymphocytic leukemia protein 1 chr1 GO:0031334 Census Yes 54 0.163 305 53 0.174 0
TCL1A TCL1A P56279 T-cell leukemia/lymphoma protein 1A chr14 GO:0031334 Census Yes 30 0.263 5 1 0.2 0
TERF1 TERF1 P54274 Telomeric repeat-binding factor 1 chr8 GO:0031334 Not Cancer Driver No 63 0.144 220 34 0.155 0
TFRC_ENST00000392396 TFRC P02786 Transferrin receptor protein 1 chr3 GO:0031334 Census Yes 89 0.117 80 6 0.075 1
TGFB1 TGFB1 P01137 Transforming growth factor beta-1 proprotein chr19 GO:0031334 Not Cancer Driver No 41 0.105 41 4 0.098 10
TIRAP_ENST00000392680 TIRAP P58753 Toll/interleukin-1 receptor domain-containing adapter protein chr11 GO:0031334 Not Cancer Driver No 28 0.127 80 6 0.075 0
TLR4_ENST00000355622 TLR4 O00206 Toll-like receptor 4 chr9 GO:0031334 Not Cancer Driver No 292 0.348 0 0 0.0 0
TLR6 TLR6 Q9Y2C9 Toll-like receptor 6 chr4 GO:0031334 Not Cancer Driver No 99 0.124 1 0 0.0 0
TNF TNF P01375 Tumor necrosis factor chr6 GO:0031334 Not Cancer Driver No 24 0.103 45 3 0.067 0
TOGARAM1_ENST00000361577 TOGARAM1 Q9Y4F4 TOG array regulator of axonemal microtubules protein 1 chr14 GO:0031334 Not Cancer Driver No 230 0.134 703 101 0.144 3
TPPP TPPP O94811 Tubulin polymerization-promoting protein chr5 GO:0031334 Not Cancer Driver No 33 0.151 149 21 0.141 0
TRABD2A TRABD2A Q86V40 Metalloprotease TIKI1 chr2 GO:0031334 Not Cancer Driver No 80 0.158 132 35 0.265 0
TRABD2B TRABD2B A6NFA1 Metalloprotease TIKI2 chr1 GO:0031334 Not Cancer Driver No 3 0.006 211 1 0.005 0
UNC13B_ENST00000378495 UNC13B O14795 Protein unc-13 homolog B chr9 GO:0031334 Not Cancer Driver No 214 0.135 448 77 0.172 0
USP50 USP50 Q70EL3 Inactive ubiquitin carboxyl-terminal hydrolase 50 chr15 GO:0031334 Not Cancer Driver No 33 0.097 2 0 0.0 0
VCP VCP P55072 Transitional endoplasmic reticulum ATPase chr9 GO:0031334 Not Cancer Driver No 88 0.109 186 16 0.086 16
VEGFA_ENST00000523873 VEGFA P15692 Vascular endothelial growth factor A chr6 GO:0031334 Not Cancer Driver No 27 0.116 41 7 0.171 0
WARS WARS1 P23381 Tryptophan--tRNA ligase, cytoplasmic chr14 GO:0031334 Not Cancer Driver No 62 0.132 90 13 0.144 1
WASHC2C_ENST00000374362 WASHC2C Q9Y4E1 WASH complex subunit 2C chr10 GO:0031334 Not Cancer Driver No 90 0.068 1204 89 0.074 0