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Total number of protein in "GO:0016616" GO term:  122

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
ABCC4_ENST00000376887 ABCC4 O15439 ATP-binding cassette sub-family C member 4 chr13 GO:0016616 Not Cancer Driver No 174 0.131 97 6 0.062 0
ADH1A ADH1A P07327 Alcohol dehydrogenase 1A chr4 GO:0016616 Not Cancer Driver No 73 0.195 6 3 0.5 0
ADH1B ADH1B P00325 All-trans-retinol dehydrogenase [NAD(+)] ADH1B chr4 GO:0016616 Not Cancer Driver No 108 0.288 6 4 0.667 0
ADH1C ADH1C P00326 Alcohol dehydrogenase 1C chr4 GO:0016616 Not Cancer Driver No 116 0.309 6 5 0.833 0
ADH4_ENST00000265512 ADH4 P08319 All-trans-retinol dehydrogenase [NAD(+)] ADH4 chr4 GO:0016616 Not Cancer Driver No 49 0.129 5 1 0.2 0
ADH5 ADH5 P11766 Alcohol dehydrogenase class-3 chr4 GO:0016616 Not Cancer Driver No 36 0.096 2 1 0.5 0
ADH6_ENST00000237653 ADH6 P28332 Alcohol dehydrogenase 6 chr4 GO:0016616 Not Cancer Driver No 71 0.193 0 0 0.0 0
ADH7_ENST00000209665 ADH7 P40394 All-trans-retinol dehydrogenase [NAD(+)] ADH7 chr4 GO:0016616 Not Cancer Driver No 74 0.192 15 2 0.133 0
ADHFE1 ADHFE1 Q8IWW8 Hydroxyacid-oxoacid transhydrogenase, mitochondrial chr8 GO:0016616 Not Cancer Driver No 63 0.135 37 8 0.216 0
AKR1A1_ENST00000621846 AKR1A1 P14550 Aldo-keto reductase family 1 member A1 chr1 GO:0016616 Not Cancer Driver No 40 0.123 26 4 0.154 0
AKR1B1 AKR1B1 P15121 Aldo-keto reductase family 1 member B1 chr7 GO:0016616 Not Cancer Driver No 52 0.165 19 1 0.053 0
AKR1B10 AKR1B10 O60218 Aldo-keto reductase family 1 member B10 chr7 GO:0016616 Not Cancer Driver No 58 0.184 28 4 0.143 0
AKR1C1 AKR1C1 Q04828 Aldo-keto reductase family 1 member C1 chr10 GO:0016616 Not Cancer Driver No 56 0.173 1 0 0.0 0
AKR1C2 AKR1C2 P52895 Aldo-keto reductase family 1 member C2 chr10 GO:0016616 Not Cancer Driver No 32 0.099 1 0 0.0 4
AKR1C3 AKR1C3 P42330 Aldo-keto reductase family 1 member C3 chr10 GO:0016616 Not Cancer Driver No 49 0.152 11 1 0.091 0
AKR1C4 AKR1C4 P17516 Aldo-keto reductase family 1 member C4 chr10 GO:0016616 Not Cancer Driver No 78 0.241 9 3 0.333 0
AKR1D1 AKR1D1 P51857 Aldo-keto reductase family 1 member D1 chr7 GO:0016616 Not Cancer Driver No 89 0.273 15 3 0.2 5
AKR1E2 AKR1E2 Q96JD6 1,5-anhydro-D-fructose reductase chr10 GO:0016616 Not Cancer Driver No 46 0.144 0 0 0.0 0
AKR7A2 AKR7A2 O43488 Aflatoxin B1 aldehyde reductase member 2 chr1 GO:0016616 Not Cancer Driver No 35 0.097 90 3 0.033 0
AKR7A3 AKR7A3 O95154 Aflatoxin B1 aldehyde reductase member 3 chr1 GO:0016616 Not Cancer Driver No 44 0.133 47 2 0.043 0
AKR7L AKR7L Q8NHP1 Aflatoxin B1 aldehyde reductase member 4 chr1 GO:0016616 Not Cancer Driver No 40 0.121 50 4 0.08 0
ALDH3A1_ENST00000444455 ALDH3A1 P30838 Aldehyde dehydrogenase, dimeric NADP-preferring chr17 GO:0016616 Not Cancer Driver No 73 0.161 36 7 0.194 0
BDH1 BDH1 Q02338 D-beta-hydroxybutyrate dehydrogenase, mitochondrial chr3 GO:0016616 Not Cancer Driver No 44 0.128 15 1 0.067 0
BDH2 BDH2 Q9BUT1 3-hydroxybutyrate dehydrogenase type 2 chr4 GO:0016616 Not Cancer Driver No 24 0.098 22 1 0.045 0
CBR1 CBR1 P16152 Carbonyl reductase [NADPH] 1 chr21 GO:0016616 Not Cancer Driver No 27 0.097 62 11 0.177 0
CBR3 CBR3 O75828 Carbonyl reductase [NADPH] 3 chr21 GO:0016616 Not Cancer Driver No 26 0.094 66 6 0.091 0
CBR4 CBR4 Q8N4T8 3-oxoacyl-[acyl-carrier-protein] reductase chr4 GO:0016616 Not Cancer Driver No 15 0.063 4 0 0.0 0
CRYL1 CRYL1 Q9Y2S2 Lambda-crystallin homolog chr13 GO:0016616 Not Cancer Driver No 36 0.113 29 3 0.103 0
CTBP1 CTBP1 Q13363 C-terminal-binding protein 1 chr4 GO:0016616 Not Cancer Driver No 42 0.095 123 9 0.073 1
CTBP2_ENST00000494626 CTBP2 P56545 C-terminal-binding protein 2 chr10 GO:0016616 Not Cancer Driver No 48 0.108 94 4 0.043 0
CYP27A1 CYP27A1 Q02318 Sterol 26-hydroxylase, mitochondrial chr2 GO:0016616 Not Cancer Driver No 69 0.13 47 11 0.234 7
CYP4A22 CYP4A22 Q5TCH4 Cytochrome P450 4A22 chr1 GO:0016616 Not Cancer Driver No 116 0.224 26 6 0.231 0
DCXR DCXR Q7Z4W1 L-xylulose reductase chr17 GO:0016616 Not Cancer Driver No 14 0.057 10 1 0.1 0
DHDH DHDH Q9UQ10 Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase chr19 GO:0016616 Not Cancer Driver No 54 0.162 18 2 0.111 0
DHRS1 DHRS1 Q96LJ7 Dehydrogenase/reductase SDR family member 1 chr14 GO:0016616 Not Cancer Driver No 22 0.07 5 0 0.0 0
DHRS13 DHRS13 Q6UX07 Dehydrogenase/reductase SDR family member 13 chr17 GO:0016616 Not Cancer Driver No 26 0.069 101 8 0.079 0
DHRS2_ENST00000250383 DHRS2 Q13268 Dehydrogenase/reductase SDR family member 2, mitochondrial chr14 GO:0016616 Not Cancer Driver No 47 0.168 0 0 0.0 0
DHRS3 DHRS3 O75911 Short-chain dehydrogenase/reductase 3 chr1 GO:0016616 Not Cancer Driver No 33 0.109 0 0 0.0 0
DHRS4 DHRS4 Q9BTZ2 Dehydrogenase/reductase SDR family member 4 chr14 GO:0016616 Not Cancer Driver No 30 0.108 38 4 0.105 0
DHRS4L2 DHRS4L2 Q6PKH6 Dehydrogenase/reductase SDR family member 4-like 2 chr14 GO:0016616 Not Cancer Driver No 24 0.103 32 4 0.125 0
DHRS7B DHRS7B Q6IAN0 Dehydrogenase/reductase SDR family member 7B chr17 GO:0016616 Not Cancer Driver No 37 0.114 17 0 0.0 0
DHRS7C DHRS7C A6NNS2 Dehydrogenase/reductase SDR family member 7C chr17 GO:0016616 Not Cancer Driver No 80 0.256 0 0 0.0 0
DHRS7_ENST00000557185 DHRS7 Q9Y394 Dehydrogenase/reductase SDR family member 7 chr14 GO:0016616 Not Cancer Driver No 37 0.109 10 0 0.0 0
DHRS9_ENST00000602501 DHRS9 Q9BPW9 Dehydrogenase/reductase SDR family member 9 chr2 GO:0016616 Not Cancer Driver No 67 0.21 3 0 0.0 0
EHHADH EHHADH Q08426 Peroxisomal bifunctional enzyme chr3 GO:0016616 Not Cancer Driver No 116 0.16 74 14 0.189 1
FASN FASN P49327 Fatty acid synthase chr17 GO:0016616 Not Cancer Driver No 291 0.116 309 42 0.136 0
G6PD_ENST00000621232 G6PD P11413 Glucose-6-phosphate 1-dehydrogenase chrX GO:0016616 Not Cancer Driver No 86 0.167 28 3 0.107 58
GCLM GCLM P48507 Glutamate--cysteine ligase regulatory subunit chr1 GO:0016616 Not Cancer Driver No 32 0.117 31 3 0.097 0
GLYR1 GLYR1 Q49A26 Putative oxidoreductase GLYR1 chr16 GO:0016616 Not Cancer Driver No 87 0.157 201 27 0.134 0
GPD1 GPD1 P21695 Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic chr12 GO:0016616 Not Cancer Driver No 59 0.169 2 0 0.0 1
GPD1L GPD1L Q8N335 Glycerol-3-phosphate dehydrogenase 1-like protein chr3 GO:0016616 Not Cancer Driver No 40 0.114 13 1 0.077 0
GRHPR GRHPR Q9UBQ7 Glyoxylate reductase/hydroxypyruvate reductase chr9 GO:0016616 Not Cancer Driver No 31 0.095 36 4 0.111 0
H6PD_ENST00000377403 H6PD O95479 GDH/6PGL endoplasmic bifunctional protein chr1 GO:0016616 Not Cancer Driver No 96 0.121 39 3 0.077 2
HADHA HADHA P40939 Trifunctional enzyme subunit alpha, mitochondrial chr2 GO:0016616 Not Cancer Driver No 72 0.094 19 2 0.105 5
HADHB HADHB P55084 Trifunctional enzyme subunit beta, mitochondrial chr2 GO:0016616 Not Cancer Driver No 71 0.15 41 9 0.22 14
HADH_ENST00000309522 HADH Q16836 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial chr4 GO:0016616 Not Cancer Driver No 33 0.105 22 5 0.227 3
HIBADH HIBADH P31937 3-hydroxyisobutyrate dehydrogenase, mitochondrial chr7 GO:0016616 Not Cancer Driver No 28 0.083 7 2 0.286 0
HMGCR_ENST00000511206 HMGCR P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase chr5 GO:0016616 Not Cancer Driver No 84 0.095 112 12 0.107 0
HPGD HPGD P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] chr4 GO:0016616 Not Cancer Driver No 32 0.12 4 1 0.25 2
HSD11B1_ENST00000367027 HSD11B1 P28845 11-beta-hydroxysteroid dehydrogenase 1 chr1 GO:0016616 Not Cancer Driver No 57 0.195 0 0 0.0 0
HSD11B2 HSD11B2 P80365 11-beta-hydroxysteroid dehydrogenase type 2 chr16 GO:0016616 Not Cancer Driver No 27 0.067 30 0 0.0 14
HSD17B10 HSD17B10 Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 chrX GO:0016616 Not Cancer Driver No 27 0.103 15 3 0.2 11
HSD17B11 HSD17B11 Q8NBQ5 Estradiol 17-beta-dehydrogenase 11 chr4 GO:0016616 Not Cancer Driver No 28 0.093 3 0 0.0 0
HSD17B12 HSD17B12 Q53GQ0 Very-long-chain 3-oxoacyl-CoA reductase chr11 GO:0016616 Not Cancer Driver No 32 0.103 9 0 0.0 0
HSD17B13 HSD17B13 Q7Z5P4 17-beta-hydroxysteroid dehydrogenase 13 chr4 GO:0016616 Not Cancer Driver No 45 0.15 0 0 0.0 0
HSD17B14 HSD17B14 Q9BPX1 17-beta-hydroxysteroid dehydrogenase 14 chr19 GO:0016616 Not Cancer Driver No 33 0.122 42 10 0.238 0
HSD17B1_ENST00000585807 HSD17B1 P14061 17-beta-hydroxysteroid dehydrogenase type 1 chr17 GO:0016616 Not Cancer Driver No 48 0.146 59 28 0.475 0
HSD17B2 HSD17B2 P37059 17-beta-hydroxysteroid dehydrogenase type 2 chr16 GO:0016616 Not Cancer Driver No 55 0.142 6 1 0.167 0
HSD17B3 HSD17B3 P37058 17-beta-hydroxysteroid dehydrogenase type 3 chr9 GO:0016616 Not Cancer Driver No 42 0.135 0 0 0.0 15
HSD17B4_ENST00000256216 HSD17B4 P51659 Peroxisomal multifunctional enzyme type 2 chr5 GO:0016616 Not Cancer Driver No 99 0.135 82 12 0.146 4
HSD17B6_ENST00000322165 HSD17B6 O14756 17-beta-hydroxysteroid dehydrogenase type 6 chr12 GO:0016616 Not Cancer Driver No 35 0.11 5 1 0.2 0
HSD17B7 HSD17B7 P56937 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 chr1 GO:0016616 Not Cancer Driver No 33 0.097 0 0 0.0 0
HSD17B8 HSD17B8 Q92506 (3R)-3-hydroxyacyl-CoA dehydrogenase chr6 GO:0016616 Not Cancer Driver No 20 0.077 26 1 0.038 0
HSD3B1 HSD3B1 P14060 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 chr1 GO:0016616 Not Cancer Driver No 69 0.185 25 3 0.12 0
HSD3B2_ENST00000369416 HSD3B2 P26439 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 chr1 GO:0016616 Not Cancer Driver No 83 0.223 24 9 0.375 28
HSD3B7 HSD3B7 Q9H2F3 3 beta-hydroxysteroid dehydrogenase type 7 chr16 GO:0016616 Not Cancer Driver No 43 0.117 27 5 0.185 2
IDH1 IDH1 O75874 Isocitrate dehydrogenase [NADP] cytoplasmic chr2 GO:0016616 Census, Compendium Yes 553 1.336 37 3 0.081 0
IDH2 IDH2 P48735 Isocitrate dehydrogenase [NADP], mitochondrial chr15 GO:0016616 Census, Compendium Yes 74 0.164 59 1 0.017 7
IDH3A IDH3A P50213 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial chr15 GO:0016616 Not Cancer Driver No 41 0.112 47 11 0.234 0
IDH3B_ENST00000380843 IDH3B O43837 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial chr20 GO:0016616 Not Cancer Driver No 32 0.083 49 3 0.061 1
IDH3G IDH3G P51553 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial chrX GO:0016616 Not Cancer Driver No 48 0.122 77 9 0.117 0
IMPDH1_ENST00000626419 IMPDH1 P20839 Inosine-5'-monophosphate dehydrogenase 1 chr7 GO:0016616 Not Cancer Driver No 75 0.146 13 1 0.077 7
IMPDH2 IMPDH2 P12268 Inosine-5'-monophosphate dehydrogenase 2 chr3 GO:0016616 Not Cancer Driver No 70 0.136 6 1 0.167 0
KCNAB1 KCNAB1 Q14722 Voltage-gated potassium channel subunit beta-1 chr3 GO:0016616 Not Cancer Driver No 89 0.212 83 23 0.277 0
KCNAB2_ENST00000378097 KCNAB2 Q13303 Voltage-gated potassium channel subunit beta-2 chr1 GO:0016616 Not Cancer Driver No 41 0.112 33 1 0.03 0
KCNAB3 KCNAB3 O43448 Voltage-gated potassium channel subunit beta-3 chr17 GO:0016616 Not Cancer Driver No 42 0.104 99 4 0.04 0
KDSR KDSR Q06136 3-ketodihydrosphingosine reductase chr18 GO:0016616 Census Yes 31 0.093 35 4 0.114 1
LDHAL6A LDHAL6A Q6ZMR3 L-lactate dehydrogenase A-like 6A chr11 GO:0016616 Not Cancer Driver No 47 0.142 16 4 0.25 0
LDHAL6B LDHAL6B Q9BYZ2 L-lactate dehydrogenase A-like 6B chr15 GO:0016616 Not Cancer Driver No 54 0.142 17 2 0.118 0
LDHA_ENST00000422447 LDHA P00338 L-lactate dehydrogenase A chain chr11 GO:0016616 Not Cancer Driver No 40 0.12 9 0 0.0 0
LDHB_ENST00000350669 LDHB P07195 L-lactate dehydrogenase B chain chr12 GO:0016616 Not Cancer Driver No 47 0.141 15 2 0.133 11
LDHC LDHC P07864 L-lactate dehydrogenase C chain chr11 GO:0016616 Not Cancer Driver No 61 0.184 0 0 0.0 0
LDHD LDHD Q86WU2 Probable D-lactate dehydrogenase, mitochondrial chr16 GO:0016616 Not Cancer Driver No 55 0.108 48 6 0.125 2
MDH1B MDH1B Q5I0G3 Putative malate dehydrogenase 1B chr2 GO:0016616 Not Cancer Driver No 103 0.199 46 13 0.283 0
MDH1_ENST00000233114 MDH1 P40925 Malate dehydrogenase, cytoplasmic chr2 GO:0016616 Not Cancer Driver No 41 0.123 18 2 0.111 1
MDH2 MDH2 P40926 Malate dehydrogenase, mitochondrial chr7 GO:0016616 Not Cancer Driver No 39 0.115 8 1 0.125 3
ME1 ME1 P48163 NADP-dependent malic enzyme chr6 GO:0016616 Not Cancer Driver No 109 0.191 64 10 0.156 0
ME2 ME2 P23368 NAD-dependent malic enzyme, mitochondrial chr18 GO:0016616 Not Cancer Driver No 69 0.118 32 5 0.156 0
ME3_ENST00000393324 ME3 Q16798 NADP-dependent malic enzyme, mitochondrial chr11 GO:0016616 Not Cancer Driver No 105 0.174 45 9 0.2 0
MIOX MIOX Q9UGB7 Inositol oxygenase chr22 GO:0016616 Not Cancer Driver No 48 0.168 21 4 0.19 0
NSDHL NSDHL Q15738 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating chrX GO:0016616 Not Cancer Driver No 60 0.161 39 6 0.154 3
PGD PGD P52209 6-phosphogluconate dehydrogenase, decarboxylating chr1 GO:0016616 Not Cancer Driver No 73 0.151 19 3 0.158 0
PHGDH_ENST00000641023 PHGDH O43175 D-3-phosphoglycerate dehydrogenase chr1 GO:0016616 Not Cancer Driver No 51 0.096 38 4 0.105 8
PTGR1_ENST00000309195 PTGR1 Q14914 Prostaglandin reductase 1 chr9 GO:0016616 Not Cancer Driver No 40 0.122 12 1 0.083 0
PTGR2 PTGR2 Q8N8N7 Prostaglandin reductase 2 chr14 GO:0016616 Not Cancer Driver No 26 0.074 22 2 0.091 0
RDH10 RDH10 Q8IZV5 Retinol dehydrogenase 10 chr8 GO:0016616 Not Cancer Driver No 33 0.097 8 0 0.0 0
RDH11 RDH11 Q8TC12 Retinol dehydrogenase 11 chr14 GO:0016616 Not Cancer Driver No 25 0.079 2 0 0.0 0
RDH12_ENST00000267502 RDH12 Q96NR8 Retinol dehydrogenase 12 chr14 GO:0016616 Not Cancer Driver No 41 0.13 0 0 0.0 10
RDH13 RDH13 Q8NBN7 Retinol dehydrogenase 13 chr19 GO:0016616 Not Cancer Driver No 42 0.127 48 7 0.146 0
RDH14 RDH14 Q9HBH5 Retinol dehydrogenase 14 chr2 GO:0016616 Not Cancer Driver No 22 0.065 21 0 0.0 0
RDH16 RDH16 O75452 Retinol dehydrogenase 16 chr12 GO:0016616 Not Cancer Driver No 46 0.145 0 0 0.0 0
RDH5_ENST00000548082 RDH5 Q92781 Retinol dehydrogenase 5 chr12 GO:0016616 Not Cancer Driver No 39 0.123 0 0 0.0 18
SDR16C5_ENST00000303749 SDR16C5 Q8N3Y7 Epidermal retinol dehydrogenase 2 chr8 GO:0016616 Not Cancer Driver No 81 0.262 4 0 0.0 0
SDR42E1 SDR42E1 Q8WUS8 Short-chain dehydrogenase/reductase family 42E member 1 chr16 GO:0016616 Not Cancer Driver No 63 0.16 26 6 0.231 0
SDR9C7 SDR9C7 Q8NEX9 Short-chain dehydrogenase/reductase family 9C member 7 chr12 GO:0016616 Not Cancer Driver No 51 0.163 3 1 0.333 2
SORD SORD Q00796 Sorbitol dehydrogenase chr15 GO:0016616 Not Cancer Driver No 29 0.081 41 7 0.171 3
SPR SPR P35270 Sepiapterin reductase chr2 GO:0016616 Not Cancer Driver No 23 0.088 19 4 0.211 2
SRD5A2 SRD5A2 P31213 3-oxo-5-alpha-steroid 4-dehydrogenase 2 chr2 GO:0016616 Not Cancer Driver No 48 0.189 0 0 0.0 21
TSTA3_ENST00000529064 GFUS Q13630 GDP-L-fucose synthase chr8 GO:0016616 Not Cancer Driver No 38 0.118 19 2 0.105 0
UEVLD UEVLD Q8IX04 Ubiquitin-conjugating enzyme E2 variant 3 chr11 GO:0016616 Not Cancer Driver No 45 0.096 14 2 0.143 0
UGDH_ENST00000506179 UGDH O60701 UDP-glucose 6-dehydrogenase chr4 GO:0016616 Not Cancer Driver No 54 0.109 39 4 0.103 5
ZADH2 PTGR3 Q8N4Q0 Prostaglandin reductase 3 chr18 GO:0016616 Not Cancer Driver No 42 0.111 0 0 0.0 0