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Total number of protein in "GO:0009411" GO term:  142

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
ACTR5 ACTR5 Q9H9F9 Actin-related protein 5 chr20 GO:0009411 Not Cancer Driver No 63 0.104 163 23 0.141 0
AKT1_ENST00000349310 AKT1 P31749 RAC-alpha serine/threonine-protein kinase chr14 GO:0009411 Census, Compendium Yes 108 0.225 158 24 0.152 4
AQP1 AQP1 P29972 Aquaporin-1 chr7 GO:0009411 Not Cancer Driver No 39 0.145 4 1 0.25 0
ATF4_ENST00000404241 ATF4 P18848 Cyclic AMP-dependent transcription factor ATF-4 chr22 GO:0009411 Not Cancer Driver No 53 0.151 259 38 0.147 0
ATR ATR Q13535 Serine/threonine-protein kinase ATR chr3 GO:0009411 Census, Compendium Yes 338 0.128 106 14 0.132 1
AURKB_ENST00000585124 AURKB Q96GD4 Aurora kinase B chr17 GO:0009411 Not Cancer Driver No 51 0.148 63 8 0.127 0
BAK1 BAK1 Q16611 Bcl-2 homologous antagonist/killer chr6 GO:0009411 Not Cancer Driver No 38 0.18 58 9 0.155 0
BAX_ENST00000345358 BAX Q07812 Apoptosis regulator BAX chr19 GO:0009411 Census Yes 30 0.156 39 2 0.051 0
BCL2_ENST00000333681 BCL2 P10415 Apoptosis regulator Bcl-2 chr18 GO:0009411 Census, Compendium Yes 24 0.1 72 5 0.069 0
BCL3 BCL3 P20749 B-cell lymphoma 3 protein chr19 GO:0009411 Census Yes 44 0.097 259 23 0.089 0
BMF_ENST00000561360 BMF Q96LC9 Bcl-2-modifying factor chr15 GO:0009411 Not Cancer Driver No 22 0.12 94 9 0.096 0
BRCA2_ENST00000544455 BRCA2 P51587 Breast cancer type 2 susceptibility protein chr13 GO:0009411 Census, Compendium Yes 457 0.134 1542 225 0.146 46
BRSK1 BRSK1 Q8TDC3 Serine/threonine-protein kinase BRSK1 chr19 GO:0009411 Not Cancer Driver No 131 0.168 459 78 0.17 0
CARD16 CARD16 Q5EG05 Caspase recruitment domain-containing protein 16 chr11 GO:0009411 Not Cancer Driver No 36 0.183 23 7 0.304 0
CASP3 CASP3 P42574 Caspase-3 chr4 GO:0009411 Census Yes 32 0.116 62 5 0.081 0
CASP7_ENST00000345633 CASP7 P55210 Caspase-7 chr10 GO:0009411 Not Cancer Driver No 38 0.125 73 10 0.137 0
CASP9 CASP9 P55211 Caspase-9 chr1 GO:0009411 Census Yes 49 0.118 71 7 0.099 0
CAT CAT P04040 Catalase chr11 GO:0009411 Not Cancer Driver No 70 0.133 176 18 0.102 0
CCAR2 CCAR2 Q8N163 Cell cycle and apoptosis regulator protein 2 chr8 GO:0009411 Not Cancer Driver No 102 0.111 528 62 0.117 0
CCND1 CCND1 P24385 G1/S-specific cyclin-D1 chr11 GO:0009411 Census, Compendium Yes 55 0.186 31 25 0.806 0
CDC25A CDC25A P30304 M-phase inducer phosphatase 1 chr3 GO:0009411 Not Cancer Driver No 63 0.12 313 35 0.112 0
CDKN1A_ENST00000373711 CDKN1A P38936 Cyclin-dependent kinase inhibitor 1 chr6 GO:0009411 Census, Compendium Yes 48 0.293 121 30 0.248 0
CDKN2D_ENST00000335766 CDKN2D P55273 Cyclin-dependent kinase 4 inhibitor D chr19 GO:0009411 Not Cancer Driver No 17 0.102 44 3 0.068 0
CERS1_ENST00000623882 CERS1 P27544 Ceramide synthase 1 chr19 GO:0009411 Not Cancer Driver No 29 0.083 19 0 0.0 1
CHEK1_ENST00000428830 CHEK1 O14757 Serine/threonine-protein kinase Chk1 chr11 GO:0009411 Not Cancer Driver No 58 0.122 86 16 0.186 0
CIRBP_ENST00000586472 CIRBP Q14011 Cold-inducible RNA-binding protein chr19 GO:0009411 Not Cancer Driver No 19 0.11 129 13 0.101 0
COPS9_ENST00000607357 COPS9 Q8WXC6 COP9 signalosome complex subunit 9 chr2 GO:0009411 Not Cancer Driver No 6 0.105 25 3 0.12 0
CREBBP CREBBP Q92793 CREB-binding protein chr16 GO:0009411 Census, Compendium Yes 412 0.169 1796 247 0.138 33
CRIP1_ENST00000409393 CRIP1 P50238 Cysteine-rich protein 1 chr14 GO:0009411 Not Cancer Driver No 6 0.078 8 1 0.125 0
CUL4B CUL4B Q13620 Cullin-4B chrX GO:0009411 Not Cancer Driver No 138 0.151 207 38 0.184 2
DCUN1D3 DCUN1D3 Q8IWE4 DCN1-like protein 3 chr16 GO:0009411 Not Cancer Driver No 36 0.118 118 9 0.076 0
DDB1 DDB1 Q16531 DNA damage-binding protein 1 chr11 GO:0009411 Not Cancer Driver No 126 0.111 50 8 0.16 4
DDB2 DDB2 Q92466 DNA damage-binding protein 2 chr11 GO:0009411 Census, Compendium Yes 45 0.105 70 5 0.071 2
DHX36 DHX36 Q9H2U1 ATP-dependent DNA/RNA helicase DHX36 chr3 GO:0009411 Not Cancer Driver No 159 0.158 222 39 0.176 0
DTL DTL Q9NZJ0 Denticleless protein homolog chr1 GO:0009411 Not Cancer Driver No 73 0.1 331 49 0.148 0
EGFR EGFR P00533 Epidermal growth factor receptor chr7 GO:0009411 Census, Compendium Yes 444 0.367 223 35 0.157 1
EIF2AK4 EIF2AK4 Q9P2K8 eIF-2-alpha kinase GCN2 chr15 GO:0009411 Not Cancer Driver No 156 0.095 494 44 0.089 2
EIF2S1 EIF2S1 P05198 Eukaryotic translation initiation factor 2 subunit 1 chr14 GO:0009411 Not Cancer Driver No 35 0.111 59 6 0.102 0
ELANE_ENST00000263621 ELANE P08246 Neutrophil elastase chr19 GO:0009411 Not Cancer Driver No 39 0.146 18 3 0.167 89
EP300 EP300 Q09472 Histone acetyltransferase p300 chr22 GO:0009411 Census, Compendium Yes 334 0.138 1790 196 0.109 1
ERCC1_ENST00000589165 ERCC1 P07992 DNA excision repair protein ERCC-1 chr19 GO:0009411 Not Cancer Driver No 42 0.141 105 14 0.133 1
ERCC2 ERCC2 P18074 General transcription and DNA repair factor IIH helicase subunit XPD chr19 GO:0009411 Census, Compendium Yes 150 0.197 5 0 0.0 35
ERCC3 ERCC3 P19447 General transcription and DNA repair factor IIH helicase subunit XPB chr2 GO:0009411 Census, Compendium Yes 92 0.118 208 22 0.106 2
ERCC4 ERCC4 Q92889 DNA repair endonuclease XPF chr16 GO:0009411 Census Yes 120 0.131 225 27 0.12 15
ERCC5 ERCC5 P28715 DNA excision repair protein ERCC-5 chr13 GO:0009411 Census Yes 175 0.148 816 121 0.148 6
ERCC6 ERCC6 Q03468 DNA excision repair protein ERCC-6 chr10 GO:0009411 Not Cancer Driver No 211 0.141 829 117 0.141 9
ERCC8 ERCC8 Q13216 DNA excision repair protein ERCC-8 chr5 GO:0009411 Not Cancer Driver No 25 0.063 53 8 0.151 7
FEN1 FEN1 P39748 Flap endonuclease 1 chr11 GO:0009411 Census Yes 35 0.092 111 11 0.099 0
FMR1 FMR1 Q06787 Synaptic functional regulator FMR1 chrX GO:0009411 Not Cancer Driver No 124 0.196 327 70 0.214 3
GPX1_ENST00000620890 GPX1 P07203 Glutathione peroxidase 1 chr3 GO:0009411 Not Cancer Driver No 38 0.187 12 1 0.083 0
GTF2H2_ENST00000330280 GTF2H2 Q13888 General transcription factor IIH subunit 2 chr5 GO:0009411 Not Cancer Driver No 7 0.018 43 1 0.023 0
HIST3H2A H2AW Q7L7L0 Histone H2A type 3 chr1 GO:0009411 Not Cancer Driver No 21 0.162 61 10 0.164 0
HUS1 HUS1 O60921 Checkpoint protein HUS1 chr7 GO:0009411 Not Cancer Driver No 25 0.089 17 2 0.118 0
HYAL1_ENST00000395144 HYAL1 Q12794 Hyaluronidase-1 chr3 GO:0009411 Not Cancer Driver No 47 0.108 9 0 0.0 1
HYAL2_ENST00000357750 HYAL2 Q12891 Hyaluronidase-2 chr3 GO:0009411 Not Cancer Driver No 52 0.11 8 1 0.125 0
HYAL3 HYAL3 O43820 Hyaluronidase-3 chr3 GO:0009411 Not Cancer Driver No 48 0.115 10 0 0.0 0
IL12B IL12B P29460 Interleukin-12 subunit beta chr5 GO:0009411 Not Cancer Driver No 48 0.146 42 2 0.048 0
IMPACT IMPACT Q9P2X3 Protein IMPACT chr18 GO:0009411 Not Cancer Driver No 49 0.153 84 12 0.143 0
INO80_ENST00000401393 INO80 Q9ULG1 Chromatin-remodeling ATPase INO80 chr15 GO:0009411 Compendium Yes 173 0.111 682 76 0.111 0
IVL IVL P07476 Involucrin chr1 GO:0009411 Not Cancer Driver No 115 0.197 585 115 0.197 0
KDM1A_ENST00000356634 KDM1A O60341 Lysine-specific histone demethylase 1A chr1 GO:0009411 Not Cancer Driver No 67 0.079 291 28 0.096 3
MAP2K7_ENST00000397979 MAP2K7 O14733 Dual specificity mitogen-activated protein kinase kinase 7 chr19 GO:0009411 Compendium Yes 89 0.212 144 20 0.139 0
MAP3K4 MAP3K4 Q9Y6R4 Mitogen-activated protein kinase kinase kinase 4 chr6 GO:0009411 Not Cancer Driver No 261 0.162 520 86 0.165 0
MAP4K3 MAP4K3 Q8IVH8 Mitogen-activated protein kinase kinase kinase kinase 3 chr2 GO:0009411 Not Cancer Driver No 116 0.13 313 45 0.144 0
MAPK13 MAPK13 O15264 Mitogen-activated protein kinase 13 chr6 GO:0009411 Not Cancer Driver No 51 0.14 50 15 0.3 0
MAPK8_ENST00000374189 MAPK8 P45983 Mitogen-activated protein kinase 8 chr10 GO:0009411 Not Cancer Driver No 64 0.15 94 9 0.096 0
MC1R_ENST00000639847 MC1R Q01726 Melanocyte-stimulating hormone receptor chr16 GO:0009411 Not Cancer Driver No 39 0.123 0 0 0.0 5
MEN1 MEN1 O00255 Menin chr11 GO:0009411 Census, Compendium Yes 73 0.119 228 15 0.066 90
METTL3 METTL3 Q86U44 N6-adenosine-methyltransferase catalytic subunit chr14 GO:0009411 Not Cancer Driver No 74 0.128 274 29 0.106 0
MFAP4_ENST00000299610 MFAP4 P55083 Microfibril-associated glycoprotein 4 chr17 GO:0009411 Not Cancer Driver No 35 0.137 0 0 0.0 0
MME_ENST00000492661 MME P08473 Neprilysin chr3 GO:0009411 Not Cancer Driver No 189 0.252 40 17 0.425 4
MMP1 MMP1 P03956 Interstitial collagenase chr11 GO:0009411 Not Cancer Driver No 83 0.177 113 18 0.159 0
MMP2 MMP2 P08253 72 kDa type IV collagenase chr16 GO:0009411 Not Cancer Driver No 123 0.186 29 6 0.207 2
MMP3 MMP3 P08254 Stromelysin-1 chr11 GO:0009411 Not Cancer Driver No 99 0.208 66 14 0.212 0
MMP9 MMP9 P14780 Matrix metalloproteinase-9 chr20 GO:0009411 Not Cancer Driver No 129 0.182 124 26 0.21 0
MSH2 MSH2 P43246 DNA mismatch repair protein Msh2 chr2 GO:0009411 Census Yes 92 0.099 37 4 0.108 70
MSH6 MSH6 P52701 DNA mismatch repair protein Msh6 chr2 GO:0009411 Census Yes 154 0.113 386 41 0.106 6
MYC_ENST00000377970 MYC P01106 Myc proto-oncogene protein chr8 GO:0009411 Census, Compendium Yes 80 0.182 299 46 0.154 0
N4BP1 N4BP1 O75113 NEDD4-binding protein 1 chr16 GO:0009411 Not Cancer Driver No 108 0.121 432 58 0.134 0
NEDD4 NEDD4 P46934 E3 ubiquitin-protein ligase NEDD4 chr15 GO:0009411 Not Cancer Driver No 150 0.114 711 79 0.111 0
NFATC4_ENST00000250373 NFATC4 Q14934 Nuclear factor of activated T-cells, cytoplasmic 4 chr14 GO:0009411 Not Cancer Driver No 155 0.172 685 120 0.175 0
NOC2L NOC2L Q9Y3T9 Nucleolar complex protein 2 homolog chr1 GO:0009411 Not Cancer Driver No 77 0.103 281 31 0.11 0
NPM1 NPM1 P06748 Nucleophosmin chr5 GO:0009411 Census, Compendium Yes 29 0.099 249 22 0.088 0
NSMCE3 NSMCE3 Q96MG7 Non-structural maintenance of chromosomes element 3 homolog chr15 GO:0009411 Not Cancer Driver No 33 0.109 128 7 0.055 2
OPN1SW OPN1SW P03999 Short-wave-sensitive opsin 1 chr7 GO:0009411 Not Cancer Driver No 65 0.187 20 1 0.05 4
OPN3 OPN3 Q9H1Y3 Opsin-3 chr1 GO:0009411 Not Cancer Driver No 39 0.097 6 1 0.167 0
OPN5 OPN5 Q6U736 Opsin-5 chr6 GO:0009411 Not Cancer Driver No 65 0.184 0 0 0.0 0
PARP1 PARP1 P09874 Poly [ADP-ribose] polymerase 1 chr1 GO:0009411 Not Cancer Driver No 119 0.117 320 34 0.106 0
PBK_ENST00000301905 PBK Q96KB5 Lymphokine-activated killer T-cell-originated protein kinase chr8 GO:0009411 Not Cancer Driver No 23 0.071 92 6 0.065 0
PCLAF PCLAF Q15004 PCNA-associated factor chr15 GO:0009411 Not Cancer Driver No 20 0.18 111 20 0.18 0
PCNA PCNA P12004 Proliferating cell nuclear antigen chr20 GO:0009411 Not Cancer Driver No 30 0.115 22 3 0.136 1
PIK3R1 PIK3R1 P27986 Phosphatidylinositol 3-kinase regulatory subunit alpha chr5 GO:0009411 Census, Compendium Yes 154 0.213 268 61 0.228 2
PML PML P29590 Protein PML chr15 GO:0009411 Census, Compendium Yes 112 0.127 312 34 0.109 0
POLD1_ENST00000440232 POLD1 P28340 DNA polymerase delta catalytic subunit chr19 GO:0009411 Census, Compendium Yes 179 0.162 214 31 0.145 2
POLH POLH Q9Y253 DNA polymerase eta chr6 GO:0009411 Not Cancer Driver No 72 0.101 291 20 0.069 10
POLK POLK Q9UBT6 DNA polymerase kappa chr5 GO:0009411 Not Cancer Driver No 97 0.111 293 36 0.123 0
PPID PPID Q08752 Peptidyl-prolyl cis-trans isomerase D chr4 GO:0009411 Not Cancer Driver No 36 0.097 94 9 0.096 0
PRIMPOL_ENST00000503752 PRIMPOL Q96LW4 DNA-directed primase/polymerase protein chr4 GO:0009411 Not Cancer Driver No 50 0.089 92 7 0.076 0
PRKAA1_ENST00000397128 PRKAA1 Q13131 5'-AMP-activated protein kinase catalytic subunit alpha-1 chr5 GO:0009411 Not Cancer Driver No 72 0.129 124 17 0.137 0
PRKCD_ENST00000330452 PRKCD Q05655 Protein kinase C delta type chr3 GO:0009411 Compendium Yes 79 0.117 43 9 0.209 0
PTGS2 PTGS2 P35354 Prostaglandin G/H synthase 2 chr1 GO:0009411 Not Cancer Driver No 105 0.174 30 5 0.167 0
PTPRK_ENST00000368215 PTPRK Q15262 Receptor-type tyrosine-protein phosphatase kappa chr6 GO:0009411 Census, Compendium Yes 292 0.203 302 57 0.189 0
RELA RELA Q04206 Transcription factor p65 chr11 GO:0009411 Compendium Yes 75 0.136 400 48 0.12 0
REV1 REV1 Q9UBZ9 DNA repair protein REV1 chr2 GO:0009411 Not Cancer Driver No 122 0.098 660 67 0.102 0
RHBDD1 RHBDD1 Q8TEB9 Rhomboid-related protein 4 chr2 GO:0009411 Not Cancer Driver No 38 0.121 69 9 0.13 0
RHNO1 RHNO1 Q9BSD3 RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 chr12 GO:0009411 Not Cancer Driver No 26 0.109 193 21 0.109 0
RPL26 RPL26 P61254 60S ribosomal protein L26 chr17 GO:0009411 Not Cancer Driver No 16 0.11 114 13 0.114 0
RUVBL2 RUVBL2 Q9Y230 RuvB-like 2 chr19 GO:0009411 Not Cancer Driver No 62 0.134 100 13 0.13 0
SCARA3 SCARA3 Q6AZY7 Scavenger receptor class A member 3 chr8 GO:0009411 Not Cancer Driver No 80 0.132 230 29 0.126 0
SDE2 SDE2 Q6IQ49 Replication stress response regulator SDE2 chr1 GO:0009411 Not Cancer Driver No 56 0.124 290 35 0.121 0
SDF4 SDF4 Q9BRK5 45 kDa calcium-binding protein chr1 GO:0009411 Not Cancer Driver No 48 0.133 187 30 0.16 0
SERPINB13_ENST00000344731 SERPINB13 Q9UIV8 Serpin B13 chr18 GO:0009411 Not Cancer Driver No 84 0.215 55 16 0.291 0
SIRT1 SIRT1 Q96EB6 NAD-dependent protein deacetylase sirtuin-1 chr10 GO:0009411 Not Cancer Driver No 70 0.094 435 31 0.071 0
SMPD1 SMPD1 P17405 Sphingomyelin phosphodiesterase chr11 GO:0009411 Not Cancer Driver No 93 0.147 51 4 0.078 111
SPRTN SPRTN Q9H040 DNA-dependent metalloprotease SPRTN chr1 GO:0009411 Not Cancer Driver No 73 0.149 252 38 0.151 1
ST20_ENST00000562759 ST20 Q9HBF5 Suppressor of tumorigenicity 20 protein chr15 GO:0009411 Not Cancer Driver No 17 0.215 0 0 0.0 0
STK11 STK11 Q15831 Serine/threonine-protein kinase STK11 chr19 GO:0009411 Census, Compendium Yes 75 0.173 135 14 0.104 9
TAF1_ENST00000373790 TAF1 P21675 Transcription initiation factor TFIID subunit 1 chrX GO:0009411 Not Cancer Driver No 379 0.202 1152 219 0.19 5
TIMP1 TIMP1 P01033 Metalloproteinase inhibitor 1 chrX GO:0009411 Not Cancer Driver No 25 0.121 0 0 0.0 0
TIPIN TIPIN Q9BVW5 TIMELESS-interacting protein chr15 GO:0009411 Not Cancer Driver No 26 0.086 242 19 0.079 0
TMEM161A TMEM161A Q9NX61 Transmembrane protein 161A chr19 GO:0009411 Not Cancer Driver No 49 0.102 22 8 0.364 0
TP53I13 TP53I13 Q8NBR0 Tumor protein p53-inducible protein 13 chr17 GO:0009411 Not Cancer Driver No 38 0.097 231 25 0.108 0
TP53INP1 TP53INP1 Q96A56 Tumor protein p53-inducible nuclear protein 1 chr8 GO:0009411 Not Cancer Driver No 32 0.133 134 20 0.149 0
TP53_ENST00000445888 TP53 P04637 Cellular tumor antigen p53 chr17 GO:0009411 Census, Compendium Yes 2891 7.356 282 1466 5.199 83
TRIAP1 TRIAP1 O43715 TP53-regulated inhibitor of apoptosis 1 chr12 GO:0009411 Not Cancer Driver No 9 0.118 20 1 0.05 0
TRIM32 TRIM32 Q13049 E3 ubiquitin-protein ligase TRIM32 chr9 GO:0009411 Not Cancer Driver No 82 0.126 87 10 0.115 3
TROVE2 RO60 P10155 RNA-binding protein RO60 chr1 GO:0009411 Not Cancer Driver No 82 0.152 17 1 0.059 0
TYR TYR P14679 Tyrosinase chr11 GO:0009411 Not Cancer Driver No 156 0.295 52 15 0.288 111
UBE2A UBE2A P49459 Ubiquitin-conjugating enzyme E2 A chrX GO:0009411 Compendium Yes 35 0.23 67 13 0.194 2
UBE2B UBE2B P63146 Ubiquitin-conjugating enzyme E2 B chr5 GO:0009411 Not Cancer Driver No 13 0.086 68 6 0.088 0
UBE4B UBE4B O95155 Ubiquitin conjugation factor E4 B chr1 GO:0009411 Not Cancer Driver No 158 0.121 434 49 0.113 0
USF1 USF1 P22415 Upstream stimulatory factor 1 chr1 GO:0009411 Not Cancer Driver No 52 0.168 271 44 0.162 0
USP1_ENST00000371146 USP1 O94782 Ubiquitin carboxyl-terminal hydrolase 1 chr1 GO:0009411 Not Cancer Driver No 63 0.08 403 30 0.074 0
USP28 USP28 Q96RU2 Ubiquitin carboxyl-terminal hydrolase 28 chr11 GO:0009411 Not Cancer Driver No 151 0.14 311 25 0.08 0
USP47 USP47 Q96K76 Ubiquitin carboxyl-terminal hydrolase 47 chr11 GO:0009411 Not Cancer Driver No 137 0.1 425 39 0.092 0
UVSSA UVSSA Q2YD98 UV-stimulated scaffold protein A chr4 GO:0009411 Not Cancer Driver No 101 0.142 519 70 0.135 1
WRN WRN Q14191 Werner syndrome ATP-dependent helicase chr8 GO:0009411 Census, Compendium Yes 164 0.115 373 41 0.11 2
XPA XPA P23025 DNA repair protein complementing XP-A cells chr9 GO:0009411 Census Yes 27 0.099 121 13 0.107 5
XPC XPC Q01831 DNA repair protein complementing XP-C cells chr3 GO:0009411 Census, Compendium Yes 88 0.094 479 48 0.1 2
YY1 YY1 P25490 Transcriptional repressor protein YY1 chr14 GO:0009411 Not Cancer Driver No 37 0.089 336 26 0.077 2
ZBTB1 ZBTB1 Q9Y2K1 Zinc finger and BTB domain-containing protein 1 chr14 GO:0009411 Not Cancer Driver No 70 0.098 271 27 0.1 0
ZRANB3 ZRANB3 Q5FWF4 DNA annealing helicase and endonuclease ZRANB3 chr2 GO:0009411 Not Cancer Driver No 126 0.117 261 31 0.119 0