Total number of protein in "GO:0008286" GO term: 61
| Identifier | UniProt Gene | UniProt Accession | UniProt Name | Chromosome | GO term | Database | Cancer Driver | Number of missense mutations | Missense mutation per residues | Number of disordered residues | Number of mutations in disordered regions | Disordered missense mutations per residues | Number of OMIM mutation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AC006486.1 | AC006486.1 | M0QYV0 | Protein kinase domain-containing protein (Fragment) | chr19 | GO:0008286 | Not Cancer Driver | No | 23 | 0.138 | 21 | 1 | 0.048 | 0 |
| AKT1_ENST00000349310 | AKT1 | P31749 | RAC-alpha serine/threonine-protein kinase | chr14 | GO:0008286 | Census, Compendium | Yes | 108 | 0.225 | 158 | 24 | 0.152 | 4 |
| AKT2 | AKT2 | P31751 | RAC-beta serine/threonine-protein kinase | chr19 | GO:0008286 | Census | Yes | 77 | 0.16 | 84 | 9 | 0.107 | 2 |
| AP3S1 | AP3S1 | Q92572 | AP-3 complex subunit sigma-1 | chr5 | GO:0008286 | Not Cancer Driver | No | 35 | 0.181 | 0 | 0 | 0.0 | 0 |
| APC | APC | P25054 | Adenomatous polyposis coli protein | chr5 | GO:0008286 | Census, Compendium | Yes | 412 | 0.145 | 2406 | 345 | 0.143 | 22 |
| APPL1 | APPL1 | Q9UKG1 | DCC-interacting protein 13-alpha | chr3 | GO:0008286 | Not Cancer Driver | No | 67 | 0.094 | 292 | 31 | 0.106 | 1 |
| BAIAP2 | BAIAP2 | Q9UQB8 | Brain-specific angiogenesis inhibitor 1-associated protein 2 | chr17 | GO:0008286 | Not Cancer Driver | No | 85 | 0.154 | 330 | 52 | 0.158 | 0 |
| BCAR1_ENST00000162330 | BCAR1 | P56945 | Breast cancer anti-estrogen resistance protein 1 | chr16 | GO:0008286 | Not Cancer Driver | No | 108 | 0.124 | 677 | 75 | 0.111 | 0 |
| BCAR3_ENST00000260502 | BCAR3 | O75815 | Breast cancer anti-estrogen resistance protein 3 | chr1 | GO:0008286 | Not Cancer Driver | No | 102 | 0.124 | 395 | 42 | 0.106 | 0 |
| C2CD5_ENST00000333957 | C2CD5 | Q86YS7 | C2 domain-containing protein 5 | chr12 | GO:0008286 | Not Cancer Driver | No | 136 | 0.136 | 250 | 40 | 0.16 | 0 |
| CAV2 | CAV2 | P51636 | Caveolin-2 | chr7 | GO:0008286 | Not Cancer Driver | No | 20 | 0.123 | 5 | 2 | 0.4 | 0 |
| CSRP3 | CSRP3 | P50461 | Cysteine and glycine-rich protein 3 | chr11 | GO:0008286 | Not Cancer Driver | No | 25 | 0.129 | 31 | 1 | 0.032 | 2 |
| DNAI1_ENST00000242317 | DNAI1 | Q9UI46 | Dynein axonemal intermediate chain 1 | chr9 | GO:0008286 | Not Cancer Driver | No | 115 | 0.165 | 297 | 49 | 0.165 | 1 |
| EIF4EBP2 | EIF4EBP2 | Q13542 | Eukaryotic translation initiation factor 4E-binding protein 2 | chr10 | GO:0008286 | Not Cancer Driver | No | 17 | 0.142 | 118 | 14 | 0.119 | 0 |
| FER | FER | P16591 | Tyrosine-protein kinase Fer | chr5 | GO:0008286 | Not Cancer Driver | No | 114 | 0.139 | 145 | 21 | 0.145 | 0 |
| FOXC2 | FOXC2 | Q99958 | Forkhead box protein C2 | chr16 | GO:0008286 | Not Cancer Driver | No | 63 | 0.126 | 369 | 33 | 0.089 | 1 |
| FOXO1 | FOXO1 | Q12778 | Forkhead box protein O1 | chr13 | GO:0008286 | Census, Compendium | Yes | 81 | 0.124 | 584 | 75 | 0.128 | 0 |
| FOXO4 | FOXO4 | P98177 | Forkhead box protein O4 | chrX | GO:0008286 | Census | Yes | 75 | 0.149 | 441 | 61 | 0.138 | 0 |
| GAB1_ENST00000262994 | GAB1 | Q13480 | GRB2-associated-binding protein 1 | chr4 | GO:0008286 | Not Cancer Driver | No | 79 | 0.114 | 570 | 68 | 0.119 | 1 |
| GPLD1 | GPLD1 | P80108 | Phosphatidylinositol-glycan-specific phospholipase D | chr6 | GO:0008286 | Not Cancer Driver | No | 153 | 0.182 | 36 | 9 | 0.25 | 0 |
| GRB10_ENST00000401949 | GRB10 | Q13322 | Growth factor receptor-bound protein 10 | chr7 | GO:0008286 | Not Cancer Driver | No | 94 | 0.158 | 220 | 38 | 0.173 | 0 |
| GRB14 | GRB14 | Q14449 | Growth factor receptor-bound protein 14 | chr2 | GO:0008286 | Not Cancer Driver | No | 83 | 0.154 | 117 | 11 | 0.094 | 0 |
| GRB2_ENST00000392564 | GRB2 | P62993 | Growth factor receptor-bound protein 2 | chr17 | GO:0008286 | Not Cancer Driver | No | 28 | 0.129 | 10 | 1 | 0.1 | 0 |
| GRB7_ENST00000394209 | GRB7 | Q14451 | Growth factor receptor-bound protein 7 | chr17 | GO:0008286 | Not Cancer Driver | No | 84 | 0.158 | 134 | 27 | 0.201 | 0 |
| GSK3A | GSK3A | P49840 | Glycogen synthase kinase-3 alpha | chr19 | GO:0008286 | Not Cancer Driver | No | 55 | 0.114 | 180 | 8 | 0.044 | 0 |
| GSK3B_ENST00000264235 | GSK3B | P49841 | Glycogen synthase kinase-3 beta | chr3 | GO:0008286 | Not Cancer Driver | No | 56 | 0.133 | 146 | 13 | 0.089 | 0 |
| IDE | IDE | P14735 | Insulin-degrading enzyme | chr10 | GO:0008286 | Not Cancer Driver | No | 90 | 0.088 | 96 | 8 | 0.083 | 0 |
| IGF1R | IGF1R | P08069 | Insulin-like growth factor 1 receptor | chr15 | GO:0008286 | Not Cancer Driver | No | 183 | 0.134 | 265 | 37 | 0.14 | 6 |
| IGF2_ENST00000641326 | IGF2 | P01344 | Insulin-like growth factor II | chr11 | GO:0008286 | Not Cancer Driver | No | 39 | 0.217 | 44 | 12 | 0.273 | 0 |
| IGFBP1 | IGFBP1 | P08833 | Insulin-like growth factor-binding protein 1 | chr7 | GO:0008286 | Not Cancer Driver | No | 47 | 0.181 | 42 | 7 | 0.167 | 0 |
| INS | INS | P01308 | Insulin | chr11 | GO:0008286 | Not Cancer Driver | No | 15 | 0.136 | 5 | 1 | 0.2 | 22 |
| INSR | INSR | P06213 | Insulin receptor | chr19 | GO:0008286 | Not Cancer Driver | No | 190 | 0.137 | 280 | 57 | 0.204 | 64 |
| INSRR | INSRR | P14616 | Insulin receptor-related protein | chr1 | GO:0008286 | Not Cancer Driver | No | 262 | 0.202 | 228 | 37 | 0.162 | 0 |
| IRS1 | IRS1 | P35568 | Insulin receptor substrate 1 | chr2 | GO:0008286 | Not Cancer Driver | No | 161 | 0.13 | 1072 | 133 | 0.124 | 2 |
| IRS2 | IRS2 | Q9Y4H2 | Insulin receptor substrate 2 | chr13 | GO:0008286 | Not Cancer Driver | No | 69 | 0.052 | 1112 | 57 | 0.051 | 0 |
| IRS4 | IRS4 | O14654 | Insulin receptor substrate 4 | chrX | GO:0008286 | Census, Compendium | Yes | 297 | 0.236 | 798 | 203 | 0.254 | 0 |
| KL | KL | Q9UEF7 | Klotho | chr13 | GO:0008286 | Not Cancer Driver | No | 175 | 0.173 | 104 | 5 | 0.048 | 1 |
| NAMPT | NAMPT | P43490 | Nicotinamide phosphoribosyltransferase | chr7 | GO:0008286 | Not Cancer Driver | No | 50 | 0.102 | 27 | 5 | 0.185 | 0 |
| NDEL1 | NDEL1 | Q9GZM8 | Nuclear distribution protein nudE-like 1 | chr17 | GO:0008286 | Not Cancer Driver | No | 32 | 0.093 | 202 | 16 | 0.079 | 0 |
| PDK2 | PDK2 | Q15119 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | chr17 | GO:0008286 | Not Cancer Driver | No | 45 | 0.111 | 35 | 4 | 0.114 | 0 |
| PDK4 | PDK4 | Q16654 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | chr7 | GO:0008286 | Not Cancer Driver | No | 70 | 0.17 | 14 | 2 | 0.143 | 0 |
| PHIP | PHIP | Q8WWQ0 | PH-interacting protein | chr6 | GO:0008286 | Not Cancer Driver | No | 239 | 0.131 | 835 | 110 | 0.132 | 0 |
| PIK3C2A | PIK3C2A | O00443 | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha | chr11 | GO:0008286 | Not Cancer Driver | No | 187 | 0.111 | 350 | 43 | 0.123 | 0 |
| PIK3CA | PIK3CA | P42336 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | chr3 | GO:0008286 | Census, Compendium | Yes | 1669 | 1.563 | 38 | 11 | 0.289 | 30 |
| PIK3R1 | PIK3R1 | P27986 | Phosphatidylinositol 3-kinase regulatory subunit alpha | chr5 | GO:0008286 | Census, Compendium | Yes | 154 | 0.213 | 268 | 61 | 0.228 | 2 |
| PIK3R2_ENST00000617130 | PIK3R2 | O00459 | Phosphatidylinositol 3-kinase regulatory subunit beta | chr19 | GO:0008286 | Not Cancer Driver | No | 96 | 0.132 | 418 | 47 | 0.112 | 3 |
| PIK3R3_ENST00000372006 | PIK3R3 | Q92569 | Phosphatidylinositol 3-kinase regulatory subunit gamma | chr1 | GO:0008286 | Not Cancer Driver | No | 51 | 0.111 | 149 | 20 | 0.134 | 0 |
| PTPN1 | PTPN1 | P18031 | Tyrosine-protein phosphatase non-receptor type 1 | chr20 | GO:0008286 | Not Cancer Driver | No | 49 | 0.113 | 140 | 25 | 0.179 | 0 |
| PTPN2 | PTPN2 | P17706 | Tyrosine-protein phosphatase non-receptor type 2 | chr18 | GO:0008286 | Not Cancer Driver | No | 57 | 0.137 | 120 | 14 | 0.117 | 0 |
| PTPRA_ENST00000399903 | PTPRA | P18433 | Receptor-type tyrosine-protein phosphatase alpha | chr20 | GO:0008286 | Not Cancer Driver | No | 98 | 0.122 | 210 | 21 | 0.1 | 0 |
| RARRES2 | RARRES2 | Q99969 | Retinoic acid receptor responder protein 2 | chr7 | GO:0008286 | Not Cancer Driver | No | 16 | 0.098 | 14 | 2 | 0.143 | 0 |
| RHOQ | RHOQ | P17081 | Rho-related GTP-binding protein RhoQ | chr2 | GO:0008286 | Not Cancer Driver | No | 25 | 0.122 | 0 | 0 | 0.0 | 0 |
| RPE65 | RPE65 | Q16518 | Retinoid isomerohydrolase | chr1 | GO:0008286 | Not Cancer Driver | No | 109 | 0.205 | 10 | 1 | 0.1 | 44 |
| SHC1_ENST00000368445 | SHC1 | P29353 | SHC-transforming protein 1 | chr1 | GO:0008286 | Not Cancer Driver | No | 84 | 0.144 | 397 | 58 | 0.146 | 0 |
| SLC2A8 | SLC2A8 | Q9NY64 | Solute carrier family 2, facilitated glucose transporter member 8 | chr9 | GO:0008286 | Not Cancer Driver | No | 28 | 0.059 | 19 | 0 | 0.0 | 0 |
| SLC39A14_ENST00000381237 | SLC39A14 | Q15043 | Metal cation symporter ZIP14 | chr8 | GO:0008286 | Not Cancer Driver | No | 34 | 0.069 | 42 | 3 | 0.071 | 4 |
| SMARCC1 | SMARCC1 | Q92922 | SWI/SNF complex subunit SMARCC1 | chr3 | GO:0008286 | Not Cancer Driver | No | 125 | 0.113 | 720 | 81 | 0.113 | 0 |
| SORBS1_ENST00000361941 | SORBS1 | Q9BX66 | Sorbin and SH3 domain-containing protein 1 | chr10 | GO:0008286 | Not Cancer Driver | No | 161 | 0.125 | 1111 | 133 | 0.12 | 0 |
| SREBF1_ENST00000261646 | SREBF1 | P36956 | Sterol regulatory element-binding protein 1 | chr17 | GO:0008286 | Not Cancer Driver | No | 127 | 0.111 | 528 | 64 | 0.121 | 4 |
| STXBP4 | STXBP4 | Q6ZWJ1 | Syntaxin-binding protein 4 | chr17 | GO:0008286 | Not Cancer Driver | No | 78 | 0.141 | 211 | 24 | 0.114 | 0 |
| ZNF106 | ZNF106 | Q9H2Y7 | Zinc finger protein 106 | chr15 | GO:0008286 | Not Cancer Driver | No | 179 | 0.095 | 1491 | 137 | 0.092 | 0 |