Total number of protein in "GO:0008217" GO term: 108
| Identifier | UniProt Gene | UniProt Accession | UniProt Name | Chromosome | GO term | Database | Cancer Driver | Number of missense mutations | Missense mutation per residues | Number of disordered residues | Number of mutations in disordered regions | Disordered missense mutations per residues | Number of OMIM mutation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ACE | ACE | P12821 | Angiotensin-converting enzyme | chr17 | GO:0008217 | Not Cancer Driver | No | 201 | 0.154 | 86 | 8 | 0.093 | 0 |
| ACE2 | ACE2 | Q9BYF1 | Angiotensin-converting enzyme 2 | chrX | GO:0008217 | Not Cancer Driver | No | 104 | 0.129 | 68 | 5 | 0.074 | 0 |
| ACSM3 | ACSM3 | Q53FZ2 | Acyl-coenzyme A synthetase ACSM3, mitochondrial | chr16 | GO:0008217 | Not Cancer Driver | No | 95 | 0.162 | 79 | 8 | 0.101 | 0 |
| ACTA2 | ACTA2 | P62736 | Actin, aortic smooth muscle | chr10 | GO:0008217 | Not Cancer Driver | No | 50 | 0.133 | 39 | 4 | 0.103 | 17 |
| ACVRL1 | ACVRL1 | P37023 | Serine/threonine-protein kinase receptor R3 | chr12 | GO:0008217 | Not Cancer Driver | No | 93 | 0.185 | 60 | 11 | 0.183 | 82 |
| ADORA1 | ADORA1 | P30542 | Adenosine receptor A1 | chr1 | GO:0008217 | Not Cancer Driver | No | 64 | 0.196 | 12 | 4 | 0.333 | 0 |
| ADRA1A_ENST00000380573 | ADRA1A | P35348 | Alpha-1A adrenergic receptor | chr8 | GO:0008217 | Not Cancer Driver | No | 130 | 0.279 | 40 | 8 | 0.2 | 0 |
| ADRB1 | ADRB1 | P08588 | Beta-1 adrenergic receptor | chr10 | GO:0008217 | Not Cancer Driver | No | 35 | 0.073 | 116 | 1 | 0.009 | 0 |
| ADRB2 | ADRB2 | P07550 | Beta-2 adrenergic receptor | chr5 | GO:0008217 | Not Cancer Driver | No | 52 | 0.126 | 35 | 4 | 0.114 | 0 |
| ADRB3 | ADRB3 | P13945 | Beta-3 adrenergic receptor | chr8 | GO:0008217 | Not Cancer Driver | No | 40 | 0.098 | 44 | 6 | 0.136 | 0 |
| AGT | AGT | P01019 | Angiotensinogen | chr1 | GO:0008217 | Not Cancer Driver | No | 85 | 0.179 | 33 | 10 | 0.303 | 1 |
| AGTR1_ENST00000349243 | AGTR1 | P30556 | Type-1 angiotensin II receptor | chr3 | GO:0008217 | Not Cancer Driver | No | 95 | 0.265 | 0 | 0 | 0.0 | 1 |
| AGTR2 | AGTR2 | P50052 | Type-2 angiotensin II receptor | chrX | GO:0008217 | Not Cancer Driver | No | 98 | 0.27 | 0 | 0 | 0.0 | 0 |
| AGTRAP | AGTRAP | Q6RW13 | Type-1 angiotensin II receptor-associated protein | chr1 | GO:0008217 | Not Cancer Driver | No | 20 | 0.126 | 11 | 0 | 0.0 | 0 |
| ANPEP | ANPEP | P15144 | Aminopeptidase N | chr15 | GO:0008217 | Not Cancer Driver | No | 175 | 0.181 | 109 | 26 | 0.239 | 0 |
| ARHGAP42 | ARHGAP42 | A6NI28 | Rho GTPase-activating protein 42 | chr11 | GO:0008217 | Not Cancer Driver | No | 63 | 0.072 | 311 | 17 | 0.055 | 0 |
| ATP1A1_ENST00000295598 | ATP1A1 | P05023 | Sodium/potassium-transporting ATPase subunit alpha-1 | chr1 | GO:0008217 | Census | Yes | 115 | 0.112 | 115 | 16 | 0.139 | 6 |
| ATP1A2 | ATP1A2 | P50993 | Sodium/potassium-transporting ATPase subunit alpha-2 | chr1 | GO:0008217 | Not Cancer Driver | No | 230 | 0.225 | 161 | 34 | 0.211 | 8 |
| ATP2B1_ENST00000261173 | ATP2B1 | P20020 | Plasma membrane calcium-transporting ATPase 1 | chr12 | GO:0008217 | Not Cancer Driver | No | 143 | 0.117 | 293 | 42 | 0.143 | 0 |
| AVP | AVP | P01185 | Vasopressin-neurophysin 2-copeptin | chr20 | GO:0008217 | Not Cancer Driver | No | 14 | 0.085 | 26 | 0 | 0.0 | 39 |
| AVPR1A | AVPR1A | P37288 | Vasopressin V1a receptor | chr12 | GO:0008217 | Not Cancer Driver | No | 105 | 0.251 | 68 | 25 | 0.368 | 0 |
| AVPR1B | AVPR1B | P47901 | Vasopressin V1b receptor | chr1 | GO:0008217 | Not Cancer Driver | No | 83 | 0.196 | 51 | 5 | 0.098 | 0 |
| AVPR2_ENST00000337474 | AVPR2 | P30518 | Vasopressin V2 receptor | chrX | GO:0008217 | Not Cancer Driver | No | 58 | 0.156 | 56 | 7 | 0.125 | 84 |
| BBS4 | BBS4 | Q96RK4 | Bardet-Biedl syndrome 4 protein | chr15 | GO:0008217 | Not Cancer Driver | No | 58 | 0.112 | 110 | 16 | 0.145 | 9 |
| BMPR2 | BMPR2 | Q13873 | Bone morphogenetic protein receptor type-2 | chr2 | GO:0008217 | Compendium | Yes | 141 | 0.136 | 601 | 70 | 0.116 | 19 |
| BRS3 | BRS3 | P32247 | Bombesin receptor subtype-3 | chrX | GO:0008217 | Not Cancer Driver | No | 72 | 0.18 | 32 | 8 | 0.25 | 0 |
| CD34 | CD34 | P28906 | Hematopoietic progenitor cell antigen CD34 | chr1 | GO:0008217 | Not Cancer Driver | No | 65 | 0.169 | 221 | 34 | 0.154 | 0 |
| CHGA | CHGA | P10645 | Chromogranin-A | chr14 | GO:0008217 | Not Cancer Driver | No | 46 | 0.101 | 421 | 44 | 0.105 | 0 |
| COL1A2 | COL1A2 | P08123 | Collagen alpha-2(I) chain | chr7 | GO:0008217 | Not Cancer Driver | No | 372 | 0.272 | 1159 | 329 | 0.284 | 83 |
| CORIN | CORIN | Q9Y5Q5 | Atrial natriuretic peptide-converting enzyme | chr4 | GO:0008217 | Not Cancer Driver | No | 208 | 0.2 | 60 | 13 | 0.217 | 2 |
| CYBA | CYBA | P13498 | Cytochrome b-245 light chain | chr16 | GO:0008217 | Not Cancer Driver | No | 26 | 0.133 | 66 | 2 | 0.03 | 12 |
| CYP11B1 | CYP11B1 | P15538 | Cytochrome P450 11B1, mitochondrial | chr8 | GO:0008217 | Not Cancer Driver | No | 177 | 0.352 | 7 | 1 | 0.143 | 50 |
| CYP11B2 | CYP11B2 | P19099 | Cytochrome P450 11B2, mitochondrial | chr8 | GO:0008217 | Not Cancer Driver | No | 148 | 0.294 | 6 | 0 | 0.0 | 6 |
| CYP4F2 | CYP4F2 | P78329 | Cytochrome P450 4F2 | chr19 | GO:0008217 | Not Cancer Driver | No | 136 | 0.262 | 17 | 3 | 0.176 | 0 |
| DLL1 | DLL1 | O00548 | Delta-like protein 1 | chr6 | GO:0008217 | Not Cancer Driver | No | 115 | 0.159 | 145 | 24 | 0.166 | 1 |
| DRD5 | DRD5 | P21918 | D(1B) dopamine receptor | chr4 | GO:0008217 | Not Cancer Driver | No | 172 | 0.361 | 29 | 18 | 0.621 | 0 |
| ECE1 | ECE1 | P42892 | Endothelin-converting enzyme 1 | chr1 | GO:0008217 | Not Cancer Driver | No | 118 | 0.153 | 99 | 26 | 0.263 | 1 |
| EDN1 | EDN1 | P05305 | Endothelin-1 | chr6 | GO:0008217 | Not Cancer Driver | No | 37 | 0.175 | 97 | 20 | 0.206 | 3 |
| EDN2 | EDN2 | P20800 | Endothelin-2 | chr1 | GO:0008217 | Not Cancer Driver | No | 21 | 0.118 | 87 | 13 | 0.149 | 0 |
| EDN3_ENST00000371028 | EDN3 | P14138 | Endothelin-3 | chr20 | GO:0008217 | Not Cancer Driver | No | 69 | 0.29 | 140 | 44 | 0.314 | 3 |
| EDNRA | EDNRA | P25101 | Endothelin-1 receptor | chr4 | GO:0008217 | Not Cancer Driver | No | 62 | 0.145 | 21 | 6 | 0.286 | 2 |
| ENPEP | ENPEP | Q07075 | Glutamyl aminopeptidase | chr4 | GO:0008217 | Compendium | Yes | 235 | 0.246 | 130 | 44 | 0.338 | 0 |
| ERAP1_ENST00000443439 | ERAP1 | Q9NZ08 | Endoplasmic reticulum aminopeptidase 1 | chr5 | GO:0008217 | Not Cancer Driver | No | 78 | 0.083 | 70 | 2 | 0.029 | 0 |
| ERAP2 | ERAP2 | Q6P179 | Endoplasmic reticulum aminopeptidase 2 | chr5 | GO:0008217 | Not Cancer Driver | No | 97 | 0.101 | 23 | 4 | 0.174 | 0 |
| EXT1 | EXT1 | Q16394 | Exostosin-1 | chr8 | GO:0008217 | Census | Yes | 107 | 0.143 | 58 | 7 | 0.121 | 12 |
| EXT2_ENST00000533608 | EXT2 | Q93063 | Exostosin-2 | chr11 | GO:0008217 | Census, Compendium | Yes | 93 | 0.13 | 12 | 1 | 0.083 | 9 |
| F2R | F2R | P25116 | Proteinase-activated receptor 1 | chr5 | GO:0008217 | Not Cancer Driver | No | 73 | 0.172 | 19 | 2 | 0.105 | 0 |
| F2RL1 | F2RL1 | P55085 | Proteinase-activated receptor 2 | chr5 | GO:0008217 | Not Cancer Driver | No | 55 | 0.139 | 7 | 2 | 0.286 | 0 |
| GCGR | GCGR | P47871 | Glucagon receptor | chr17 | GO:0008217 | Not Cancer Driver | No | 16 | 0.034 | 56 | 2 | 0.036 | 4 |
| GCH1_ENST00000622544 | GCH1 | P30793 | GTP cyclohydrolase 1 | chr14 | GO:0008217 | Not Cancer Driver | No | 20 | 0.08 | 99 | 5 | 0.051 | 38 |
| GNA11 | GNA11 | P29992 | Guanine nucleotide-binding protein subunit alpha-11 | chr19 | GO:0008217 | Census, Compendium | Yes | 48 | 0.134 | 10 | 0 | 0.0 | 5 |
| GNA12 | GNA12 | Q03113 | Guanine nucleotide-binding protein subunit alpha-12 | chr7 | GO:0008217 | Not Cancer Driver | No | 41 | 0.108 | 20 | 0 | 0.0 | 0 |
| GNA13 | GNA13 | Q14344 | Guanine nucleotide-binding protein subunit alpha-13 | chr17 | GO:0008217 | Compendium | Yes | 52 | 0.138 | 32 | 4 | 0.125 | 0 |
| GNB3 | GNB3 | P16520 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 | chr12 | GO:0008217 | Not Cancer Driver | No | 51 | 0.15 | 13 | 1 | 0.077 | 0 |
| GPR37L1 | GPR37L1 | O60883 | G-protein coupled receptor 37-like 1 | chr1 | GO:0008217 | Not Cancer Driver | No | 62 | 0.129 | 81 | 8 | 0.099 | 0 |
| GUCY1A1_ENST00000513574 | GUCY1A1 | Q02108 | Guanylate cyclase soluble subunit alpha-1 | chr4 | GO:0008217 | Not Cancer Driver | No | 181 | 0.262 | 54 | 8 | 0.148 | 0 |
| HBB | HBB | P68871 | Hemoglobin subunit beta | chr11 | GO:0008217 | Not Cancer Driver | No | 45 | 0.306 | 7 | 2 | 0.286 | 5 |
| HMOX1 | HMOX1 | P09601 | Heme oxygenase 1 | chr22 | GO:0008217 | Not Cancer Driver | No | 46 | 0.16 | 81 | 13 | 0.16 | 0 |
| HSD11B2 | HSD11B2 | P80365 | 11-beta-hydroxysteroid dehydrogenase type 2 | chr16 | GO:0008217 | Not Cancer Driver | No | 27 | 0.067 | 30 | 0 | 0.0 | 14 |
| KCNK6 | KCNK6 | Q9Y257 | Potassium channel subfamily K member 6 | chr19 | GO:0008217 | Not Cancer Driver | No | 39 | 0.125 | 22 | 4 | 0.182 | 0 |
| KCNQ1 | KCNQ1 | P51787 | Potassium voltage-gated channel subfamily KQT member 1 | chr11 | GO:0008217 | Not Cancer Driver | No | 78 | 0.115 | 219 | 20 | 0.091 | 132 |
| KL | KL | Q9UEF7 | Klotho | chr13 | GO:0008217 | Not Cancer Driver | No | 175 | 0.173 | 104 | 5 | 0.048 | 1 |
| LEP | LEP | P41159 | Leptin | chr7 | GO:0008217 | Not Cancer Driver | No | 29 | 0.174 | 0 | 0 | 0.0 | 2 |
| LNPEP | LNPEP | Q9UIQ6 | Leucyl-cystinyl aminopeptidase | chr5 | GO:0008217 | Not Cancer Driver | No | 115 | 0.112 | 103 | 8 | 0.078 | 0 |
| LRP5 | LRP5 | O75197 | Low-density lipoprotein receptor-related protein 5 | chr11 | GO:0008217 | Not Cancer Driver | No | 253 | 0.157 | 188 | 28 | 0.149 | 55 |
| LVRN | LVRN | Q6Q4G3 | Aminopeptidase Q | chr5 | GO:0008217 | Not Cancer Driver | No | 212 | 0.214 | 81 | 20 | 0.247 | 0 |
| MC3R | MC3R | P41968 | Melanocortin receptor 3 | chr20 | GO:0008217 | Not Cancer Driver | No | 96 | 0.297 | 0 | 0 | 0.0 | 0 |
| MYH6 | MYH6 | P13533 | Myosin-6 | chr14 | GO:0008217 | Not Cancer Driver | No | 392 | 0.202 | 1112 | 238 | 0.214 | 7 |
| NOS3 | NOS3 | P29474 | Nitric oxide synthase, endothelial | chr7 | GO:0008217 | Not Cancer Driver | No | 168 | 0.14 | 347 | 38 | 0.11 | 0 |
| NOX1 | NOX1 | Q9Y5S8 | NADPH oxidase 1 | chrX | GO:0008217 | Not Cancer Driver | No | 101 | 0.179 | 18 | 8 | 0.444 | 0 |
| NPPA | NPPA | P01160 | Natriuretic peptides A | chr1 | GO:0008217 | Not Cancer Driver | No | 32 | 0.212 | 71 | 14 | 0.197 | 1 |
| NPPB | NPPB | P16860 | Natriuretic peptides B | chr1 | GO:0008217 | Not Cancer Driver | No | 31 | 0.231 | 104 | 28 | 0.269 | 0 |
| NPR1 | NPR1 | P16066 | Atrial natriuretic peptide receptor 1 | chr1 | GO:0008217 | Not Cancer Driver | No | 141 | 0.133 | 78 | 16 | 0.205 | 0 |
| NPR2 | NPR2 | P20594 | Atrial natriuretic peptide receptor 2 | chr9 | GO:0008217 | Not Cancer Driver | No | 144 | 0.138 | 89 | 18 | 0.202 | 20 |
| NPR3 | NPR3 | P17342 | Atrial natriuretic peptide receptor 3 | chr5 | GO:0008217 | Not Cancer Driver | No | 95 | 0.176 | 58 | 8 | 0.138 | 0 |
| NPY1R | NPY1R | P25929 | Neuropeptide Y receptor type 1 | chr4 | GO:0008217 | Not Cancer Driver | No | 114 | 0.297 | 4 | 0 | 0.0 | 0 |
| NR2F2 | NR2F2 | P24468 | COUP transcription factor 2 | chr15 | GO:0008217 | Not Cancer Driver | No | 66 | 0.159 | 101 | 1 | 0.01 | 5 |
| NTSR1 | NTSR1 | P30989 | Neurotensin receptor type 1 | chr20 | GO:0008217 | Not Cancer Driver | No | 85 | 0.203 | 23 | 1 | 0.043 | 0 |
| OR51E2_ENST00000641638 | OR51E2 | Q9H255 | Olfactory receptor 51E2 | chr11 | GO:0008217 | Not Cancer Driver | No | 108 | 0.338 | 0 | 0 | 0.0 | 0 |
| OXTR | OXTR | P30559 | Oxytocin receptor | chr3 | GO:0008217 | Not Cancer Driver | No | 46 | 0.118 | 18 | 0 | 0.0 | 0 |
| P2RX1 | P2RX1 | P51575 | P2X purinoceptor 1 | chr17 | GO:0008217 | Not Cancer Driver | No | 59 | 0.148 | 14 | 1 | 0.071 | 0 |
| P2RX4_ENST00000337233 | P2RX4 | Q99571 | P2X purinoceptor 4 | chr12 | GO:0008217 | Not Cancer Driver | No | 36 | 0.093 | 0 | 0 | 0.0 | 0 |
| POMC | POMC | P01189 | Pro-opiomelanocortin | chr2 | GO:0008217 | Not Cancer Driver | No | 50 | 0.187 | 198 | 38 | 0.192 | 0 |
| PPARG | PPARG | P37231 | Peroxisome proliferator-activated receptor gamma | chr3 | GO:0008217 | Census | Yes | 72 | 0.143 | 44 | 4 | 0.091 | 3 |
| PRCP_ENST00000313010 | PRCP | P42785 | Lysosomal Pro-X carboxypeptidase | chr11 | GO:0008217 | Not Cancer Driver | No | 58 | 0.117 | 0 | 0 | 0.0 | 0 |
| PTGS1 | PTGS1 | P23219 | Prostaglandin G/H synthase 1 | chr9 | GO:0008217 | Not Cancer Driver | No | 123 | 0.205 | 28 | 3 | 0.107 | 0 |
| PTGS2 | PTGS2 | P35354 | Prostaglandin G/H synthase 2 | chr1 | GO:0008217 | Not Cancer Driver | No | 105 | 0.174 | 30 | 5 | 0.167 | 0 |
| RAMP2 | RAMP2 | O60895 | Receptor activity-modifying protein 2 | chr17 | GO:0008217 | Not Cancer Driver | No | 18 | 0.103 | 34 | 6 | 0.176 | 0 |
| REN | REN | P00797 | Renin | chr1 | GO:0008217 | Not Cancer Driver | No | 60 | 0.148 | 10 | 0 | 0.0 | 3 |
| RENBP | RENBP | P51606 | N-acylglucosamine 2-epimerase | chrX | GO:0008217 | Not Cancer Driver | No | 65 | 0.152 | 64 | 10 | 0.156 | 0 |
| RHOA | RHOA | P61586 | Transforming protein RhoA | chr3 | GO:0008217 | Census, Compendium | Yes | 99 | 0.513 | 46 | 13 | 0.283 | 2 |
| RPS6KA2_ENST00000265678 | RPS6KA2 | Q15349 | Ribosomal protein S6 kinase alpha-2 | chr6 | GO:0008217 | Not Cancer Driver | No | 133 | 0.181 | 91 | 15 | 0.165 | 0 |
| SERPINF2_ENST00000382061 | SERPINF2 | P08697 | Alpha-2-antiplasmin | chr17 | GO:0008217 | Not Cancer Driver | No | 62 | 0.126 | 112 | 21 | 0.188 | 1 |
| SGK1_ENST00000237305 | SGK1 | O00141 | Serine/threonine-protein kinase Sgk1 | chr6 | GO:0008217 | Census, Compendium | Yes | 58 | 0.135 | 86 | 16 | 0.186 | 0 |
| SLC2A5 | SLC2A5 | P22732 | Solute carrier family 2, facilitated glucose transporter member 5 | chr1 | GO:0008217 | Not Cancer Driver | No | 73 | 0.146 | 12 | 4 | 0.333 | 0 |
| SMAD3 | SMAD3 | P84022 | Mothers against decapentaplegic homolog 3 | chr15 | GO:0008217 | Census, Compendium | Yes | 97 | 0.228 | 111 | 19 | 0.171 | 5 |
| SOD1 | SOD1 | P00441 | Superoxide dismutase [Cu-Zn] | chr21 | GO:0008217 | Not Cancer Driver | No | 16 | 0.104 | 93 | 9 | 0.097 | 79 |
| SOD2_ENST00000367055 | SOD2 | P04179 | Superoxide dismutase [Mn], mitochondrial | chr6 | GO:0008217 | Not Cancer Driver | No | 32 | 0.144 | 25 | 5 | 0.2 | 0 |
| SPX | SPX | Q9BT56 | Spexin | chr12 | GO:0008217 | Not Cancer Driver | No | 22 | 0.19 | 40 | 8 | 0.2 | 0 |
| STK39 | STK39 | Q9UEW8 | STE20/SPS1-related proline-alanine-rich protein kinase | chr2 | GO:0008217 | Not Cancer Driver | No | 64 | 0.117 | 182 | 19 | 0.104 | 0 |
| TAC4 | TAC4 | Q86UU9 | Tachykinin-4 | chr17 | GO:0008217 | Not Cancer Driver | No | 15 | 0.133 | 27 | 4 | 0.148 | 0 |
| TNF | TNF | P01375 | Tumor necrosis factor | chr6 | GO:0008217 | Not Cancer Driver | No | 24 | 0.103 | 45 | 3 | 0.067 | 0 |
| TRHDE | TRHDE | Q9UKU6 | Thyrotropin-releasing hormone-degrading ectoenzyme | chr12 | GO:0008217 | Not Cancer Driver | No | 346 | 0.338 | 104 | 11 | 0.106 | 0 |
| TRPV1_ENST00000399756 | TRPV1 | Q8NER1 | Transient receptor potential cation channel subfamily V member 1 | chr17 | GO:0008217 | Not Cancer Driver | No | 93 | 0.111 | 155 | 18 | 0.116 | 0 |
| UTS2B_ENST00000427544 | UTS2B | Q765I0 | Urotensin-2B | chr3 | GO:0008217 | Not Cancer Driver | No | 17 | 0.143 | 2 | 0 | 0.0 | 0 |
| UTS2R | UTS2R | Q9UKP6 | Urotensin-2 receptor | chr17 | GO:0008217 | Not Cancer Driver | No | 45 | 0.116 | 74 | 5 | 0.068 | 0 |
| UTS2_ENST00000361696 | UTS2 | O95399 | Urotensin-2 | chr1 | GO:0008217 | Not Cancer Driver | No | 16 | 0.129 | 0 | 0 | 0.0 | 0 |
| WNK1_ENST00000315939 | WNK1 | Q9H4A3 | Serine/threonine-protein kinase WNK1 | chr12 | GO:0008217 | Not Cancer Driver | No | 278 | 0.117 | 1959 | 223 | 0.114 | 0 |