Total number of protein in "GO:0008081" GO term: 71
| Identifier | UniProt Gene | UniProt Accession | UniProt Name | Chromosome | GO term | Database | Cancer Driver | Number of missense mutations | Missense mutation per residues | Number of disordered residues | Number of mutations in disordered regions | Disordered missense mutations per residues | Number of OMIM mutation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ADPRM | ADPRM | Q3LIE5 | Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase | chr17 | GO:0008081 | Not Cancer Driver | No | 38 | 0.111 | 32 | 4 | 0.125 | 0 |
| APEX1_ENST00000555414 | APEX1 | P27695 | DNA-(apurinic or apyrimidinic site) endonuclease | chr14 | GO:0008081 | Not Cancer Driver | No | 34 | 0.107 | 103 | 14 | 0.136 | 0 |
| APEX2 | APEX2 | Q9UBZ4 | DNA-(apurinic or apyrimidinic site) endonuclease 2 | chrX | GO:0008081 | Not Cancer Driver | No | 66 | 0.127 | 148 | 14 | 0.095 | 0 |
| BDKRB2 | BDKRB2 | P30411 | B2 bradykinin receptor | chr14 | GO:0008081 | Not Cancer Driver | No | 81 | 0.207 | 0 | 0 | 0.0 | 0 |
| CASR_ENST00000638421 | CASR | P41180 | Extracellular calcium-sensing receptor | chr3 | GO:0008081 | Not Cancer Driver | No | 304 | 0.282 | 189 | 60 | 0.317 | 108 |
| CCR1 | CCR1 | P32246 | C-C chemokine receptor type 1 | chr3 | GO:0008081 | Not Cancer Driver | No | 69 | 0.194 | 14 | 5 | 0.357 | 0 |
| CCR5 | CCR5 | P51681 | C-C chemokine receptor type 5 | chr3 | GO:0008081 | Not Cancer Driver | No | 107 | 0.304 | 0 | 0 | 0.0 | 0 |
| CHRM1 | CHRM1 | P11229 | Muscarinic acetylcholine receptor M1 | chr11 | GO:0008081 | Not Cancer Driver | No | 63 | 0.137 | 131 | 24 | 0.183 | 0 |
| CHRM3_ENST00000615928 | CHRM3 | P20309 | Muscarinic acetylcholine receptor M3 | chr1 | GO:0008081 | Not Cancer Driver | No | 182 | 0.308 | 136 | 42 | 0.309 | 0 |
| CHRM5 | CHRM5 | P08912 | Muscarinic acetylcholine receptor M5 | chr15 | GO:0008081 | Not Cancer Driver | No | 74 | 0.139 | 155 | 20 | 0.129 | 0 |
| CNP | CNP | P09543 | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | chr17 | GO:0008081 | Not Cancer Driver | No | 36 | 0.086 | 71 | 2 | 0.028 | 0 |
| EDNRA | EDNRA | P25101 | Endothelin-1 receptor | chr4 | GO:0008081 | Not Cancer Driver | No | 62 | 0.145 | 21 | 6 | 0.286 | 2 |
| ENPP1 | ENPP1 | P22413 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 | chr6 | GO:0008081 | Not Cancer Driver | No | 148 | 0.16 | 101 | 5 | 0.05 | 33 |
| ENPP2_ENST00000075322 | ENPP2 | Q13822 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | chr8 | GO:0008081 | Not Cancer Driver | No | 168 | 0.195 | 81 | 16 | 0.198 | 0 |
| ENPP3_ENST00000357639 | ENPP3 | O14638 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 | chr6 | GO:0008081 | Not Cancer Driver | No | 146 | 0.167 | 57 | 12 | 0.211 | 0 |
| ENPP6 | ENPP6 | Q6UWR7 | Glycerophosphocholine cholinephosphodiesterase ENPP6 | chr4 | GO:0008081 | Not Cancer Driver | No | 88 | 0.2 | 7 | 1 | 0.143 | 0 |
| ENPP7 | ENPP7 | Q6UWV6 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 | chr17 | GO:0008081 | Not Cancer Driver | No | 102 | 0.223 | 65 | 19 | 0.292 | 0 |
| F2RL2 | F2RL2 | O00254 | Proteinase-activated receptor 3 | chr5 | GO:0008081 | Not Cancer Driver | No | 54 | 0.144 | 0 | 0 | 0.0 | 0 |
| FAM83B | FAM83B | Q5T0W9 | Protein FAM83B | chr6 | GO:0008081 | Not Cancer Driver | No | 314 | 0.311 | 684 | 219 | 0.32 | 0 |
| FAN1 | FAN1 | Q9Y2M0 | Fanconi-associated nuclease 1 | chr15 | GO:0008081 | Not Cancer Driver | No | 124 | 0.122 | 212 | 27 | 0.127 | 4 |
| FICD | FICD | Q9BVA6 | Protein adenylyltransferase FICD | chr12 | GO:0008081 | Not Cancer Driver | No | 46 | 0.1 | 42 | 3 | 0.071 | 0 |
| GDE1 | GDE1 | Q9NZC3 | Glycerophosphodiester phosphodiesterase 1 | chr16 | GO:0008081 | Not Cancer Driver | No | 36 | 0.109 | 37 | 1 | 0.027 | 0 |
| GDPD1 | GDPD1 | Q8N9F7 | Lysophospholipase D GDPD1 | chr17 | GO:0008081 | Not Cancer Driver | No | 47 | 0.15 | 6 | 0 | 0.0 | 0 |
| GDPD2_ENST00000374382 | GDPD2 | Q9HCC8 | Glycerophosphoinositol inositolphosphodiesterase GDPD2 | chrX | GO:0008081 | Not Cancer Driver | No | 96 | 0.178 | 43 | 15 | 0.349 | 0 |
| GDPD3 | GDPD3 | Q7L5L3 | Lysophospholipase D GDPD3 | chr16 | GO:0008081 | Not Cancer Driver | No | 50 | 0.157 | 12 | 2 | 0.167 | 0 |
| GDPD4_ENST00000376217 | GDPD4 | Q6W3E5 | Glycerophosphodiester phosphodiesterase domain-containing protein 4 | chr11 | GO:0008081 | Not Cancer Driver | No | 89 | 0.143 | 114 | 8 | 0.07 | 0 |
| GDPD5_ENST00000529721 | GDPD5 | Q8WTR4 | Glycerophosphodiester phosphodiesterase domain-containing protein 5 | chr11 | GO:0008081 | Not Cancer Driver | No | 74 | 0.122 | 65 | 11 | 0.169 | 0 |
| GPCPD1 | GPCPD1 | Q9NPB8 | Glycerophosphocholine phosphodiesterase GPCPD1 | chr20 | GO:0008081 | Not Cancer Driver | No | 69 | 0.103 | 60 | 8 | 0.133 | 0 |
| GPLD1 | GPLD1 | P80108 | Phosphatidylinositol-glycan-specific phospholipase D | chr6 | GO:0008081 | Not Cancer Driver | No | 153 | 0.182 | 36 | 9 | 0.25 | 0 |
| HMOX1 | HMOX1 | P09601 | Heme oxygenase 1 | chr22 | GO:0008081 | Not Cancer Driver | No | 46 | 0.16 | 81 | 13 | 0.16 | 0 |
| MPPE1 | MPPE1 | Q53F39 | Metallophosphoesterase 1 | chr18 | GO:0008081 | Not Cancer Driver | No | 39 | 0.098 | 27 | 5 | 0.185 | 0 |
| MPPED2 | MPPED2 | Q15777 | Metallophosphoesterase MPPED2 | chr11 | GO:0008081 | Not Cancer Driver | No | 82 | 0.279 | 58 | 22 | 0.379 | 0 |
| NAPEPLD | NAPEPLD | Q6IQ20 | N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D | chr7 | GO:0008081 | Not Cancer Driver | No | 55 | 0.14 | 76 | 7 | 0.092 | 0 |
| PDE10A_ENST00000366882 | PDE10A | Q9Y233 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | chr6 | GO:0008081 | Not Cancer Driver | No | 198 | 0.254 | 79 | 21 | 0.266 | 4 |
| PDE1A_ENST00000410103 | PDE1A | P54750 | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A | chr2 | GO:0008081 | Not Cancer Driver | No | 157 | 0.293 | 61 | 7 | 0.115 | 0 |
| PDE1B | PDE1B | Q01064 | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B | chr12 | GO:0008081 | Not Cancer Driver | No | 114 | 0.213 | 132 | 30 | 0.227 | 0 |
| PDE1C_ENST00000321453 | PDE1C | Q14123 | Dual specificity Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C | chr7 | GO:0008081 | Not Cancer Driver | No | 253 | 0.357 | 281 | 97 | 0.345 | 1 |
| PDE2A | PDE2A | O00408 | cGMP-dependent 3',5'-cyclic phosphodiesterase | chr11 | GO:0008081 | Not Cancer Driver | No | 137 | 0.146 | 99 | 7 | 0.071 | 0 |
| PDE3A | PDE3A | Q14432 | cGMP-inhibited 3',5'-cyclic phosphodiesterase A | chr12 | GO:0008081 | Not Cancer Driver | No | 274 | 0.24 | 527 | 114 | 0.216 | 6 |
| PDE3B | PDE3B | Q13370 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | chr11 | GO:0008081 | Not Cancer Driver | No | 135 | 0.121 | 393 | 37 | 0.094 | 0 |
| PLCB1 | PLCB1 | Q9NQ66 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | chr20 | GO:0008081 | Not Cancer Driver | No | 313 | 0.257 | 481 | 104 | 0.216 | 0 |
| PLCB2 | PLCB2 | Q00722 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 | chr15 | GO:0008081 | Not Cancer Driver | No | 161 | 0.136 | 495 | 51 | 0.103 | 0 |
| PLCB3 | PLCB3 | Q01970 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 | chr11 | GO:0008081 | Not Cancer Driver | No | 144 | 0.117 | 595 | 68 | 0.114 | 1 |
| PLCB4_ENST00000278655 | PLCB4 | Q15147 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 | chr20 | GO:0008081 | Compendium | Yes | 338 | 0.288 | 401 | 120 | 0.299 | 5 |
| PLCD1_ENST00000334661 | PLCD1 | P51178 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 | chr3 | GO:0008081 | Not Cancer Driver | No | 94 | 0.124 | 111 | 13 | 0.117 | 2 |
| PLCD3 | PLCD3 | Q8N3E9 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 | chr17 | GO:0008081 | Not Cancer Driver | No | 61 | 0.077 | 229 | 22 | 0.096 | 0 |
| PLCD4_ENST00000417849 | PLCD4 | Q9BRC7 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 | chr2 | GO:0008081 | Not Cancer Driver | No | 78 | 0.102 | 90 | 5 | 0.056 | 0 |
| PLCE1 | PLCE1 | Q9P212 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 | chr10 | GO:0008081 | Not Cancer Driver | No | 367 | 0.159 | 780 | 107 | 0.137 | 1 |
| PLCG1_ENST00000373271 | PLCG1 | P19174 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | chr20 | GO:0008081 | Census, Compendium | Yes | 158 | 0.122 | 186 | 21 | 0.113 | 0 |
| PLCG2 | PLCG2 | P16885 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 | chr16 | GO:0008081 | Not Cancer Driver | No | 248 | 0.196 | 142 | 30 | 0.211 | 1 |
| PLCH1 | PLCH1 | Q4KWH8 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 | chr3 | GO:0008081 | Not Cancer Driver | No | 383 | 0.226 | 772 | 195 | 0.253 | 0 |
| PLCH2 | PLCH2 | O75038 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 | chr1 | GO:0008081 | Not Cancer Driver | No | 145 | 0.102 | 786 | 71 | 0.09 | 0 |
| PLCL1 | PLCL1 | Q15111 | Inactive phospholipase C-like protein 1 | chr2 | GO:0008081 | Not Cancer Driver | No | 258 | 0.236 | 205 | 33 | 0.161 | 0 |
| PLCL2 | PLCL2 | Q9UPR0 | Inactive phospholipase C-like protein 2 | chr3 | GO:0008081 | Not Cancer Driver | No | 185 | 0.164 | 274 | 31 | 0.113 | 0 |
| PLCXD1_ENST00000399012 | PLCXD1 | Q9NUJ7 | PI-PLC X domain-containing protein 1 | chrX | GO:0008081 | Not Cancer Driver | No | 46 | 0.142 | 2 | 0 | 0.0 | 0 |
| PLCXD2 | PLCXD2 | Q0VAA5 | PI-PLC X domain-containing protein 2 | chr3 | GO:0008081 | Not Cancer Driver | No | 59 | 0.193 | 30 | 4 | 0.133 | 0 |
| PLCXD3_ENST00000328457 | PLCXD3 | Q63HM9 | PI-PLC X domain-containing protein 3 | chr5 | GO:0008081 | Not Cancer Driver | No | 115 | 0.358 | 14 | 1 | 0.071 | 0 |
| PLCZ1 | PLCZ1 | Q86YW0 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 | chr12 | GO:0008081 | Not Cancer Driver | No | 151 | 0.248 | 37 | 20 | 0.541 | 1 |
| PLD1 | PLD1 | Q13393 | Phospholipase D1 | chr3 | GO:0008081 | Not Cancer Driver | No | 181 | 0.169 | 133 | 32 | 0.241 | 1 |
| PLD2 | PLD2 | O14939 | Phospholipase D2 | chr17 | GO:0008081 | Not Cancer Driver | No | 107 | 0.115 | 97 | 8 | 0.082 | 0 |
| PLD3_ENST00000409735 | PLD3 | Q8IV08 | 5'-3' exonuclease PLD3 | chr19 | GO:0008081 | Not Cancer Driver | No | 70 | 0.143 | 62 | 7 | 0.113 | 0 |
| PLD4_ENST00000392593 | PLD4 | Q96BZ4 | 5'-3' exonuclease PLD4 | chr14 | GO:0008081 | Not Cancer Driver | No | 46 | 0.091 | 76 | 10 | 0.132 | 0 |
| PLD6 | PLD6 | Q8N2A8 | Mitochondrial cardiolipin hydrolase | chr17 | GO:0008081 | Not Cancer Driver | No | 27 | 0.107 | 24 | 6 | 0.25 | 0 |
| SMPD1 | SMPD1 | P17405 | Sphingomyelin phosphodiesterase | chr11 | GO:0008081 | Not Cancer Driver | No | 93 | 0.147 | 51 | 4 | 0.078 | 111 |
| SMPD2 | SMPD2 | O60906 | Sphingomyelin phosphodiesterase 2 | chr6 | GO:0008081 | Not Cancer Driver | No | 45 | 0.106 | 48 | 5 | 0.104 | 0 |
| SMPD3 | SMPD3 | Q9NY59 | Sphingomyelin phosphodiesterase 3 | chr16 | GO:0008081 | Not Cancer Driver | No | 92 | 0.14 | 224 | 29 | 0.129 | 0 |
| SMPD4 | SMPD4 | Q9NXE4 | Sphingomyelin phosphodiesterase 4 | chr2 | GO:0008081 | Not Cancer Driver | No | 114 | 0.132 | 80 | 12 | 0.15 | 1 |
| SMPDL3A | SMPDL3A | Q92484 | Acid sphingomyelinase-like phosphodiesterase 3a | chr6 | GO:0008081 | Not Cancer Driver | No | 56 | 0.124 | 36 | 3 | 0.083 | 0 |
| SMPDL3B | SMPDL3B | Q92485 | Acid sphingomyelinase-like phosphodiesterase 3b | chr1 | GO:0008081 | Not Cancer Driver | No | 61 | 0.134 | 22 | 7 | 0.318 | 0 |
| TDP1_ENST00000393454 | TDP1 | Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | chr14 | GO:0008081 | Not Cancer Driver | No | 81 | 0.133 | 179 | 25 | 0.14 | 1 |
| TDP2 | TDP2 | O95551 | Tyrosyl-DNA phosphodiesterase 2 | chr6 | GO:0008081 | Not Cancer Driver | No | 55 | 0.152 | 80 | 10 | 0.125 | 0 |