Total number of protein in "GO:0007219" GO term: 107
| Identifier | UniProt Gene | UniProt Accession | UniProt Name | Chromosome | GO term | Database | Cancer Driver | Number of missense mutations | Missense mutation per residues | Number of disordered residues | Number of mutations in disordered regions | Disordered missense mutations per residues | Number of OMIM mutation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ADAM10 | ADAM10 | O14672 | Disintegrin and metalloproteinase domain-containing protein 10 | chr15 | GO:0007219 | Not Cancer Driver | No | 88 | 0.118 | 156 | 20 | 0.128 | 4 |
| ADAM17 | ADAM17 | P78536 | Disintegrin and metalloproteinase domain-containing protein 17 | chr2 | GO:0007219 | Not Cancer Driver | No | 80 | 0.097 | 182 | 17 | 0.093 | 0 |
| AGXT | AGXT | P21549 | Alanine--glyoxylate aminotransferase | chr2 | GO:0007219 | Not Cancer Driver | No | 56 | 0.143 | 20 | 0 | 0.0 | 40 |
| ANGPT4 | ANGPT4 | Q9Y264 | Angiopoietin-4 | chr20 | GO:0007219 | Not Cancer Driver | No | 104 | 0.207 | 150 | 32 | 0.213 | 0 |
| ANXA4 | ANXA4 | P09525 | Annexin A4 | chr2 | GO:0007219 | Not Cancer Driver | No | 47 | 0.147 | 41 | 6 | 0.146 | 0 |
| APH1A | APH1A | Q96BI3 | Gamma-secretase subunit APH-1A | chr1 | GO:0007219 | Not Cancer Driver | No | 32 | 0.121 | 0 | 0 | 0.0 | 0 |
| APH1B | APH1B | Q8WW43 | Gamma-secretase subunit APH-1B | chr15 | GO:0007219 | Not Cancer Driver | No | 21 | 0.082 | 0 | 0 | 0.0 | 0 |
| APP | APP | P05067 | Amyloid-beta precursor protein | chr21 | GO:0007219 | Not Cancer Driver | No | 128 | 0.166 | 418 | 71 | 0.17 | 17 |
| ASCL1 | ASCL1 | P50553 | Achaete-scute homolog 1 | chr12 | GO:0007219 | Not Cancer Driver | No | 33 | 0.14 | 182 | 24 | 0.132 | 0 |
| ATOH1 | ATOH1 | Q92858 | Transcription factor ATOH1 | chr4 | GO:0007219 | Not Cancer Driver | No | 63 | 0.178 | 327 | 55 | 0.168 | 0 |
| BLOC1S2 | BLOC1S2 | Q6QNY1 | Biogenesis of lysosome-related organelles complex 1 subunit 2 | chr10 | GO:0007219 | Not Cancer Driver | No | 17 | 0.12 | 34 | 6 | 0.176 | 0 |
| BMP2 | BMP2 | P12643 | Bone morphogenetic protein 2 | chr20 | GO:0007219 | Not Cancer Driver | No | 73 | 0.184 | 139 | 26 | 0.187 | 0 |
| CDH6 | CDH6 | P55285 | Cadherin-6 | chr5 | GO:0007219 | Not Cancer Driver | No | 250 | 0.316 | 337 | 102 | 0.303 | 0 |
| CDK6 | CDK6 | Q00534 | Cyclin-dependent kinase 6 | chr7 | GO:0007219 | Census | Yes | 40 | 0.123 | 24 | 3 | 0.125 | 1 |
| CDKN1B | CDKN1B | P46527 | Cyclin-dependent kinase inhibitor 1B | chr12 | GO:0007219 | Census, Compendium | Yes | 19 | 0.096 | 198 | 19 | 0.096 | 0 |
| CEBPA | CEBPA | P49715 | CCAAT/enhancer-binding protein alpha | chr19 | GO:0007219 | Census, Compendium | Yes | 12 | 0.034 | 342 | 12 | 0.035 | 1 |
| CFAP58 | CFAP58 | Q5T655 | Cilia- and flagella-associated protein 58 | chr10 | GO:0007219 | Not Cancer Driver | No | 207 | 0.237 | 392 | 81 | 0.207 | 0 |
| CFD_ENST00000327726 | CFD | P00746 | Complement factor D | chr19 | GO:0007219 | Not Cancer Driver | No | 6 | 0.024 | 69 | 3 | 0.043 | 2 |
| CHAC1_ENST00000617961 | CHAC1 | Q9BUX1 | Glutathione-specific gamma-glutamylcyclotransferase 1 | chr15 | GO:0007219 | Not Cancer Driver | No | 30 | 0.135 | 49 | 5 | 0.102 | 0 |
| CNTN1 | CNTN1 | Q12860 | Contactin-1 | chr12 | GO:0007219 | Not Cancer Driver | No | 265 | 0.26 | 220 | 50 | 0.227 | 0 |
| CNTN6_ENST00000350110 | CNTN6 | Q9UQ52 | Contactin-6 | chr3 | GO:0007219 | Not Cancer Driver | No | 330 | 0.321 | 173 | 59 | 0.341 | 0 |
| DLL1 | DLL1 | O00548 | Delta-like protein 1 | chr6 | GO:0007219 | Not Cancer Driver | No | 115 | 0.159 | 145 | 24 | 0.166 | 1 |
| DLL3 | DLL3 | Q9NYJ7 | Delta-like protein 3 | chr19 | GO:0007219 | Not Cancer Driver | No | 73 | 0.118 | 119 | 10 | 0.084 | 1 |
| DLL4 | DLL4 | Q9NR61 | Delta-like protein 4 | chr15 | GO:0007219 | Not Cancer Driver | No | 75 | 0.109 | 73 | 15 | 0.205 | 7 |
| DNER | DNER | Q8NFT8 | Delta and Notch-like epidermal growth factor-related receptor | chr2 | GO:0007219 | Not Cancer Driver | No | 162 | 0.22 | 106 | 26 | 0.245 | 0 |
| DTX1 | DTX1 | Q86Y01 | E3 ubiquitin-protein ligase DTX1 | chr12 | GO:0007219 | Compendium | Yes | 107 | 0.173 | 304 | 43 | 0.141 | 0 |
| DTX2 | DTX2 | Q86UW9 | Probable E3 ubiquitin-protein ligase DTX2 | chr7 | GO:0007219 | Not Cancer Driver | No | 84 | 0.135 | 292 | 42 | 0.144 | 0 |
| DTX3L | DTX3L | Q8TDB6 | E3 ubiquitin-protein ligase DTX3L | chr3 | GO:0007219 | Not Cancer Driver | No | 86 | 0.116 | 260 | 24 | 0.092 | 0 |
| DTX3_ENST00000337737 | DTX3 | Q8N9I9 | Probable E3 ubiquitin-protein ligase DTX3 | chr12 | GO:0007219 | Not Cancer Driver | No | 58 | 0.167 | 182 | 31 | 0.17 | 0 |
| DTX4 | DTX4 | Q9Y2E6 | E3 ubiquitin-protein ligase DTX4 | chr11 | GO:0007219 | Not Cancer Driver | No | 84 | 0.136 | 323 | 57 | 0.176 | 0 |
| EPN1_ENST00000270460 | EPN1 | Q9Y6I3 | Epsin-1 | chr19 | GO:0007219 | Not Cancer Driver | No | 87 | 0.151 | 493 | 71 | 0.144 | 0 |
| ETV2_ENST00000403402 | ETV2 | O00321 | ETS translocation variant 2 | chr19 | GO:0007219 | Not Cancer Driver | No | 23 | 0.067 | 227 | 15 | 0.066 | 0 |
| FBXW7_ENST00000603841 | FBXW7 | Q969H0 | F-box/WD repeat-containing protein 7 | chr4 | GO:0007219 | Census, Compendium | Yes | 322 | 0.455 | 230 | 38 | 0.165 | 0 |
| FOXA1 | FOXA1 | P55317 | Hepatocyte nuclear factor 3-alpha | chr14 | GO:0007219 | Census, Compendium | Yes | 100 | 0.212 | 295 | 53 | 0.18 | 0 |
| FOXC1_ENST00000645831 | FOXC1 | Q12948 | Forkhead box protein C1 | chr6 | GO:0007219 | Not Cancer Driver | No | 33 | 0.06 | 411 | 24 | 0.058 | 32 |
| FOXC2 | FOXC2 | Q99958 | Forkhead box protein C2 | chr16 | GO:0007219 | Not Cancer Driver | No | 63 | 0.126 | 369 | 33 | 0.089 | 1 |
| GALNT11_ENST00000430044 | GALNT11 | Q8NCW6 | Polypeptide N-acetylgalactosaminyltransferase 11 | chr7 | GO:0007219 | Not Cancer Driver | No | 73 | 0.12 | 91 | 18 | 0.198 | 0 |
| GMDS | GMDS | O60547 | GDP-mannose 4,6 dehydratase | chr6 | GO:0007219 | Not Cancer Driver | No | 51 | 0.137 | 53 | 6 | 0.113 | 0 |
| GOT1 | GOT1 | P17174 | Aspartate aminotransferase, cytoplasmic | chr10 | GO:0007219 | Not Cancer Driver | No | 56 | 0.136 | 35 | 5 | 0.143 | 0 |
| GRIP2_ENST00000621039 | GRIP2 | Q9C0E4 | Glutamate receptor-interacting protein 2 | chr3 | GO:0007219 | Not Cancer Driver | No | 143 | 0.137 | 586 | 84 | 0.143 | 0 |
| HES1 | HES1 | Q14469 | Transcription factor HES-1 | chr3 | GO:0007219 | Not Cancer Driver | No | 37 | 0.132 | 226 | 32 | 0.142 | 0 |
| HES3 | HES3 | Q5TGS1 | Transcription factor HES-3 | chr1 | GO:0007219 | Not Cancer Driver | No | 13 | 0.07 | 129 | 10 | 0.078 | 0 |
| HES5 | HES5 | Q5TA89 | Transcription factor HES-5 | chr1 | GO:0007219 | Not Cancer Driver | No | 1 | 0.006 | 73 | 0 | 0.0 | 0 |
| HES7_ENST00000317814 | HES7 | Q9BYE0 | Transcription factor HES-7 | chr17 | GO:0007219 | Not Cancer Driver | No | 7 | 0.031 | 166 | 5 | 0.03 | 3 |
| HEY1_ENST00000354724 | HEY1 | Q9Y5J3 | Hairy/enhancer-of-split related with YRPW motif protein 1 | chr8 | GO:0007219 | Census | Yes | 33 | 0.109 | 172 | 15 | 0.087 | 0 |
| HEY2 | HEY2 | Q9UBP5 | Hairy/enhancer-of-split related with YRPW motif protein 2 | chr6 | GO:0007219 | Not Cancer Driver | No | 64 | 0.19 | 179 | 26 | 0.145 | 0 |
| HEYL | HEYL | Q9NQ87 | Hairy/enhancer-of-split related with YRPW motif-like protein | chr1 | GO:0007219 | Not Cancer Driver | No | 44 | 0.134 | 198 | 19 | 0.096 | 0 |
| HOXD3 | HOXD3 | P31249 | Homeobox protein Hox-D3 | chr2 | GO:0007219 | Not Cancer Driver | No | 68 | 0.157 | 354 | 64 | 0.181 | 0 |
| IFT172 | IFT172 | Q9UG01 | Intraflagellar transport protein 172 homolog | chr2 | GO:0007219 | Not Cancer Driver | No | 219 | 0.125 | 96 | 10 | 0.104 | 8 |
| IFT74_ENST00000433700 | IFT74 | Q96LB3 | Intraflagellar transport protein 74 homolog | chr9 | GO:0007219 | Not Cancer Driver | No | 47 | 0.078 | 490 | 38 | 0.078 | 0 |
| IL17A | IL17A | Q16552 | Interleukin-17A | chr6 | GO:0007219 | Not Cancer Driver | No | 52 | 0.335 | 56 | 21 | 0.375 | 0 |
| IL2RA | IL2RA | P01589 | Interleukin-2 receptor subunit alpha | chr10 | GO:0007219 | Not Cancer Driver | No | 51 | 0.188 | 131 | 29 | 0.221 | 2 |
| ITGB1BP1_ENST00000355346 | ITGB1BP1 | O14713 | Integrin beta-1-binding protein 1 | chr2 | GO:0007219 | Not Cancer Driver | No | 26 | 0.13 | 58 | 11 | 0.19 | 0 |
| JAG1 | JAG1 | P78504 | Protein jagged-1 | chr20 | GO:0007219 | Not Cancer Driver | No | 182 | 0.149 | 172 | 20 | 0.116 | 52 |
| JAG2 | JAG2 | Q9Y219 | Protein jagged-2 | chr14 | GO:0007219 | Not Cancer Driver | No | 126 | 0.102 | 158 | 24 | 0.152 | 0 |
| KCNA5 | KCNA5 | P22460 | Potassium voltage-gated channel subfamily A member 5 | chr12 | GO:0007219 | Not Cancer Driver | No | 213 | 0.347 | 218 | 53 | 0.243 | 0 |
| KRT19 | KRT19 | P08727 | Keratin, type I cytoskeletal 19 | chr17 | GO:0007219 | Not Cancer Driver | No | 57 | 0.142 | 165 | 19 | 0.115 | 0 |
| MAML1 | MAML1 | Q92585 | Mastermind-like protein 1 | chr5 | GO:0007219 | Not Cancer Driver | No | 102 | 0.1 | 1009 | 102 | 0.101 | 0 |
| MAML2 | MAML2 | Q8IZL2 | Mastermind-like protein 2 | chr11 | GO:0007219 | Census, Compendium | Yes | 146 | 0.126 | 1156 | 146 | 0.126 | 0 |
| MAML3 | MAML3 | Q96JK9 | Mastermind-like protein 3 | chr4 | GO:0007219 | Not Cancer Driver | No | 123 | 0.108 | 1119 | 123 | 0.11 | 0 |
| MESP1 | MESP1 | Q9BRJ9 | Mesoderm posterior protein 1 | chr15 | GO:0007219 | Not Cancer Driver | No | 8 | 0.03 | 247 | 7 | 0.028 | 0 |
| MESP2 | MESP2 | Q0VG99 | Mesoderm posterior protein 2 | chr15 | GO:0007219 | Not Cancer Driver | No | 34 | 0.086 | 340 | 27 | 0.079 | 0 |
| MIB1 | MIB1 | Q86YT6 | E3 ubiquitin-protein ligase MIB1 | chr18 | GO:0007219 | Not Cancer Driver | No | 122 | 0.121 | 282 | 34 | 0.121 | 1 |
| MIB2_ENST00000504599 | MIB2 | Q96AX9 | E3 ubiquitin-protein ligase MIB2 | chr1 | GO:0007219 | Not Cancer Driver | No | 88 | 0.092 | 307 | 31 | 0.101 | 0 |
| NCSTN | NCSTN | Q92542 | Nicastrin | chr1 | GO:0007219 | Not Cancer Driver | No | 94 | 0.133 | 72 | 11 | 0.153 | 1 |
| NEURL1 | NEURL1 | O76050 | E3 ubiquitin-protein ligase NEURL1 | chr10 | GO:0007219 | Not Cancer Driver | No | 62 | 0.108 | 153 | 11 | 0.072 | 0 |
| NEURL1B | NEURL1B | A8MQ27 | E3 ubiquitin-protein ligase NEURL1B | chr5 | GO:0007219 | Not Cancer Driver | No | 8 | 0.014 | 250 | 3 | 0.012 | 0 |
| NEUROD4 | NEUROD4 | Q9HD90 | Neurogenic differentiation factor 4 | chr12 | GO:0007219 | Not Cancer Driver | No | 123 | 0.372 | 236 | 83 | 0.352 | 0 |
| NKAP | NKAP | Q8N5F7 | NF-kappa-B-activating protein | chrX | GO:0007219 | Not Cancer Driver | No | 80 | 0.193 | 409 | 77 | 0.188 | 3 |
| NLE1 | NLE1 | Q9NVX2 | Notchless protein homolog 1 | chr17 | GO:0007219 | Not Cancer Driver | No | 60 | 0.124 | 21 | 3 | 0.143 | 0 |
| NOTCH1 | NOTCH1 | P46531 | Neurogenic locus notch homolog protein 1 | chr9 | GO:0007219 | Census, Compendium | Yes | 363 | 0.142 | 686 | 87 | 0.127 | 3 |
| NOTCH2 | NOTCH2 | Q04721 | Neurogenic locus notch homolog protein 2 | chr1 | GO:0007219 | Census, Compendium | Yes | 282 | 0.114 | 630 | 77 | 0.122 | 1 |
| NOTCH2NLA | NOTCH2NLA | Q7Z3S9 | Notch homolog 2 N-terminal-like protein A | chr1 | GO:0007219 | Not Cancer Driver | No | 68 | 0.288 | 17 | 2 | 0.118 | 0 |
| NOTCH3 | NOTCH3 | Q9UM47 | Neurogenic locus notch homolog protein 3 | chr19 | GO:0007219 | Not Cancer Driver | No | 306 | 0.132 | 557 | 81 | 0.145 | 110 |
| NR0B2 | NR0B2 | Q15466 | Nuclear receptor subfamily 0 group B member 2 | chr1 | GO:0007219 | Not Cancer Driver | No | 35 | 0.136 | 10 | 2 | 0.2 | 0 |
| NR1H4 | NR1H4 | Q96RI1 | Bile acid receptor | chr12 | GO:0007219 | Not Cancer Driver | No | 111 | 0.228 | 78 | 18 | 0.231 | 0 |
| NRARP | NRARP | Q7Z6K4 | Notch-regulated ankyrin repeat-containing protein | chr9 | GO:0007219 | Not Cancer Driver | No | 9 | 0.079 | 11 | 1 | 0.091 | 0 |
| ONECUT1 | ONECUT1 | Q9UBC0 | Hepatocyte nuclear factor 6 | chr15 | GO:0007219 | Not Cancer Driver | No | 78 | 0.168 | 405 | 65 | 0.16 | 0 |
| PERP | PERP | Q96FX8 | p53 apoptosis effector related to PMP-22 | chr6 | GO:0007219 | Not Cancer Driver | No | 28 | 0.145 | 0 | 0 | 0.0 | 1 |
| PGAM2 | PGAM2 | P15259 | Phosphoglycerate mutase 2 | chr7 | GO:0007219 | Not Cancer Driver | No | 46 | 0.182 | 81 | 14 | 0.173 | 3 |
| PLN | PLN | P26678 | Cardiac phospholamban | chr6 | GO:0007219 | Not Cancer Driver | No | 10 | 0.192 | 0 | 0 | 0.0 | 3 |
| POFUT1 | POFUT1 | Q9H488 | GDP-fucose protein O-fucosyltransferase 1 | chr20 | GO:0007219 | Not Cancer Driver | No | 56 | 0.144 | 17 | 2 | 0.118 | 0 |
| PSEN1 | PSEN1 | P49768 | Presenilin-1 | chr14 | GO:0007219 | Not Cancer Driver | No | 61 | 0.131 | 134 | 21 | 0.157 | 96 |
| PSEN2 | PSEN2 | P49810 | Presenilin-2 | chr1 | GO:0007219 | Not Cancer Driver | No | 68 | 0.152 | 89 | 16 | 0.18 | 7 |
| PSENEN_ENST00000222266 | PSENEN | Q9NZ42 | Gamma-secretase subunit PEN-2 | chr19 | GO:0007219 | Not Cancer Driver | No | 17 | 0.168 | 0 | 0 | 0.0 | 0 |
| PTP4A3_ENST00000521578 | PTP4A3 | O75365 | Protein tyrosine phosphatase type IVA 3 | chr8 | GO:0007219 | Not Cancer Driver | No | 30 | 0.173 | 3 | 0 | 0.0 | 0 |
| RBPJ_ENST00000361572 | RBPJ | Q06330 | Recombining binding protein suppressor of hairless | chr4 | GO:0007219 | Not Cancer Driver | No | 49 | 0.098 | 151 | 19 | 0.126 | 2 |
| RIPPLY2 | RIPPLY2 | Q5TAB7 | Protein ripply2 | chr6 | GO:0007219 | Not Cancer Driver | No | 24 | 0.188 | 82 | 15 | 0.183 | 0 |
| RITA1_ENST00000548278 | RITA1 | Q96K30 | RBPJ-interacting and tubulin-associated protein 1 | chr12 | GO:0007219 | Not Cancer Driver | No | 27 | 0.1 | 271 | 28 | 0.103 | 0 |
| S1PR3 | S1PR3 | Q99500 | Sphingosine 1-phosphate receptor 3 | chr9 | GO:0007219 | Not Cancer Driver | No | 69 | 0.183 | 28 | 4 | 0.143 | 0 |
| SEL1L | SEL1L | Q9UBV2 | Protein sel-1 homolog 1 | chr14 | GO:0007219 | Not Cancer Driver | No | 95 | 0.12 | 187 | 18 | 0.096 | 0 |
| SIX1_ENST00000645694 | SIX1 | Q15475 | Homeobox protein SIX1 | chr14 | GO:0007219 | Census, Compendium | Yes | 49 | 0.173 | 144 | 25 | 0.174 | 8 |
| SNAI1 | SNAI1 | O95863 | Zinc finger protein SNAI1 | chr20 | GO:0007219 | Not Cancer Driver | No | 52 | 0.197 | 97 | 11 | 0.113 | 0 |
| SNAI2_ENST00000020945 | SNAI2 | O43623 | Zinc finger protein SNAI2 | chr8 | GO:0007219 | Not Cancer Driver | No | 52 | 0.194 | 52 | 9 | 0.173 | 0 |
| SORBS2_ENST00000284776 | SORBS2 | O94875 | Sorbin and SH3 domain-containing protein 2 | chr4 | GO:0007219 | Not Cancer Driver | No | 172 | 0.156 | 854 | 137 | 0.16 | 0 |
| SOX9 | SOX9 | P48436 | Transcription factor SOX-9 | chr17 | GO:0007219 | Compendium | Yes | 86 | 0.169 | 495 | 82 | 0.166 | 18 |
| SPEN | SPEN | Q96T58 | Msx2-interacting protein | chr1 | GO:0007219 | Census, Compendium | Yes | 459 | 0.125 | 3061 | 393 | 0.128 | 0 |
| SUSD5 | SUSD5 | O60279 | Sushi domain-containing protein 5 | chr3 | GO:0007219 | Not Cancer Driver | No | 82 | 0.13 | 358 | 57 | 0.159 | 0 |
| TBX2 | TBX2 | Q13207 | T-box transcription factor TBX2 | chr17 | GO:0007219 | Not Cancer Driver | No | 74 | 0.104 | 401 | 36 | 0.09 | 1 |
| TGFBR2_ENST00000295754 | TGFBR2 | P37173 | TGF-beta receptor type-2 | chr3 | GO:0007219 | Census, Compendium | Yes | 106 | 0.187 | 60 | 16 | 0.267 | 25 |
| TIMP4 | TIMP4 | Q99727 | Metalloproteinase inhibitor 4 | chr3 | GO:0007219 | Not Cancer Driver | No | 30 | 0.134 | 8 | 2 | 0.25 | 0 |
| TMEM100 | TMEM100 | Q9NV29 | Transmembrane protein 100 | chr17 | GO:0007219 | Not Cancer Driver | No | 29 | 0.216 | 0 | 0 | 0.0 | 0 |
| TP63 | TP63 | Q9H3D4 | Tumor protein 63 | chr3 | GO:0007219 | Census, Compendium | Yes | 229 | 0.337 | 398 | 143 | 0.359 | 28 |
| TRAF7 | TRAF7 | Q6Q0C0 | E3 ubiquitin-protein ligase TRAF7 | chr16 | GO:0007219 | Census | Yes | 76 | 0.113 | 120 | 14 | 0.117 | 4 |
| TSPEAR_ENST00000613245 | TSPEAR | Q8WU66 | Thrombospondin-type laminin G domain and EAR repeat-containing protein | chr21 | GO:0007219 | Not Cancer Driver | No | 131 | 0.196 | 7 | 1 | 0.143 | 0 |
| WDR12 | WDR12 | Q9GZL7 | Ribosome biogenesis protein WDR12 | chr2 | GO:0007219 | Not Cancer Driver | No | 39 | 0.092 | 36 | 1 | 0.028 | 0 |
| ZNF423 | ZNF423 | Q2M1K9 | Zinc finger protein 423 | chr16 | GO:0007219 | Not Cancer Driver | No | 340 | 0.265 | 416 | 108 | 0.26 | 2 |