Total number of protein in "GO:0007179" GO term: 88
| Identifier | UniProt Gene | UniProt Accession | UniProt Name | Chromosome | GO term | Database | Cancer Driver | Number of missense mutations | Missense mutation per residues | Number of disordered residues | Number of mutations in disordered regions | Disordered missense mutations per residues | Number of OMIM mutation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ACVR1_ENST00000434821 | ACVR1 | Q04771 | Activin receptor type-1 | chr2 | GO:0007179 | Census, Compendium | Yes | 78 | 0.153 | 21 | 8 | 0.381 | 8 |
| ACVRL1 | ACVRL1 | P37023 | Serine/threonine-protein kinase receptor R3 | chr12 | GO:0007179 | Not Cancer Driver | No | 93 | 0.185 | 60 | 11 | 0.183 | 82 |
| ADAM9 | ADAM9 | Q13443 | Disintegrin and metalloproteinase domain-containing protein 9 | chr8 | GO:0007179 | Not Cancer Driver | No | 86 | 0.105 | 129 | 13 | 0.101 | 0 |
| AMHR2 | AMHR2 | Q16671 | Anti-Muellerian hormone type-2 receptor | chr12 | GO:0007179 | Not Cancer Driver | No | 77 | 0.134 | 117 | 7 | 0.06 | 8 |
| APOA1_ENST00000375320 | APOA1 | P02647 | Apolipoprotein A-I | chr11 | GO:0007179 | Not Cancer Driver | No | 28 | 0.105 | 131 | 8 | 0.061 | 3 |
| APPL1 | APPL1 | Q9UKG1 | DCC-interacting protein 13-alpha | chr3 | GO:0007179 | Not Cancer Driver | No | 67 | 0.094 | 292 | 31 | 0.106 | 1 |
| APPL2_ENST00000258530 | APPL2 | Q8NEU8 | DCC-interacting protein 13-beta | chr12 | GO:0007179 | Not Cancer Driver | No | 70 | 0.105 | 149 | 14 | 0.094 | 0 |
| ARRB2_ENST00000269260 | ARRB2 | P32121 | Beta-arrestin-2 | chr17 | GO:0007179 | Not Cancer Driver | No | 46 | 0.112 | 122 | 22 | 0.18 | 0 |
| BAMBI | BAMBI | Q13145 | BMP and activin membrane-bound inhibitor homolog | chr10 | GO:0007179 | Not Cancer Driver | No | 42 | 0.162 | 31 | 7 | 0.226 | 0 |
| BMPR1A | BMPR1A | P36894 | Bone morphogenetic protein receptor type-1A | chr10 | GO:0007179 | Census, Compendium | Yes | 66 | 0.124 | 21 | 0 | 0.0 | 8 |
| CDH5 | CDH5 | P33151 | Cadherin-5 | chr16 | GO:0007179 | Not Cancer Driver | No | 144 | 0.184 | 305 | 55 | 0.18 | 0 |
| CITED1_ENST00000246139 | CITED1 | Q99966 | Cbp/p300-interacting transactivator 1 | chrX | GO:0007179 | Not Cancer Driver | No | 24 | 0.124 | 166 | 21 | 0.127 | 0 |
| CITED2_ENST00000367651 | CITED2 | Q99967 | Cbp/p300-interacting transactivator 2 | chr6 | GO:0007179 | Not Cancer Driver | No | 23 | 0.085 | 230 | 18 | 0.078 | 0 |
| CLDN5_ENST00000618236 | CLDN5 | O00501 | Claudin-5 | chr22 | GO:0007179 | Not Cancer Driver | No | 15 | 0.069 | 0 | 0 | 0.0 | 0 |
| COL1A2 | COL1A2 | P08123 | Collagen alpha-2(I) chain | chr7 | GO:0007179 | Not Cancer Driver | No | 372 | 0.272 | 1159 | 329 | 0.284 | 83 |
| COL3A1 | COL3A1 | P02461 | Collagen alpha-1(III) chain | chr2 | GO:0007179 | Census | Yes | 402 | 0.274 | 1182 | 337 | 0.285 | 103 |
| DUSP15 | DUSP15 | Q9H1R2 | Dual specificity protein phosphatase 15 | chr20 | GO:0007179 | Not Cancer Driver | No | 36 | 0.122 | 122 | 19 | 0.156 | 0 |
| DUSP22_ENST00000344450 | DUSP22 | Q9NRW4 | Dual specificity protein phosphatase 22 | chr6 | GO:0007179 | Not Cancer Driver | No | 84 | 0.457 | 0 | 0 | 0.0 | 0 |
| ENG | ENG | P17813 | Endoglin | chr9 | GO:0007179 | Not Cancer Driver | No | 60 | 0.091 | 114 | 15 | 0.132 | 32 |
| FERMT2_ENST00000395631 | FERMT2 | Q96AC1 | Fermitin family homolog 2 | chr14 | GO:0007179 | Not Cancer Driver | No | 71 | 0.104 | 101 | 10 | 0.099 | 0 |
| FNTA | FNTA | P49354 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | chr8 | GO:0007179 | Not Cancer Driver | No | 43 | 0.113 | 92 | 12 | 0.13 | 0 |
| FOS | FOS | P01100 | Protein c-Fos | chr14 | GO:0007179 | Not Cancer Driver | No | 45 | 0.118 | 245 | 33 | 0.135 | 0 |
| FOXH1 | FOXH1 | O75593 | Forkhead box protein H1 | chr8 | GO:0007179 | Not Cancer Driver | No | 47 | 0.129 | 215 | 25 | 0.116 | 0 |
| FSHB_ENST00000254122 | FSHB | P01225 | Follitropin subunit beta | chr11 | GO:0007179 | Not Cancer Driver | No | 31 | 0.24 | 0 | 0 | 0.0 | 1 |
| FURIN_ENST00000610579 | FURIN | P09958 | Furin | chr15 | GO:0007179 | Not Cancer Driver | No | 93 | 0.117 | 283 | 35 | 0.124 | 0 |
| FUT8_ENST00000394586 | FUT8 | Q9BYC5 | Alpha-(1,6)-fucosyltransferase | chr14 | GO:0007179 | Not Cancer Driver | No | 79 | 0.137 | 80 | 19 | 0.237 | 1 |
| GCNT2_ENST00000379597 | GCNT2 | Q8N0V5 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase | chr6 | GO:0007179 | Not Cancer Driver | No | 40 | 0.1 | 3 | 0 | 0.0 | 0 |
| GDF15 | GDF15 | Q99988 | Growth/differentiation factor 15 | chr19 | GO:0007179 | Not Cancer Driver | No | 39 | 0.127 | 143 | 20 | 0.14 | 0 |
| GDF5_ENST00000374369 | GDF5 | P43026 | Growth/differentiation factor 5 | chr20 | GO:0007179 | Not Cancer Driver | No | 104 | 0.208 | 255 | 50 | 0.196 | 24 |
| GDF9 | GDF9 | O60383 | Growth/differentiation factor 9 | chr5 | GO:0007179 | Not Cancer Driver | No | 72 | 0.159 | 53 | 15 | 0.283 | 0 |
| HIPK2 | HIPK2 | Q9H2X6 | Homeodomain-interacting protein kinase 2 | chr7 | GO:0007179 | Not Cancer Driver | No | 154 | 0.129 | 686 | 96 | 0.14 | 0 |
| HPGD | HPGD | P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | chr4 | GO:0007179 | Not Cancer Driver | No | 32 | 0.12 | 4 | 1 | 0.25 | 2 |
| ID1 | ID1 | P41134 | DNA-binding protein inhibitor ID-1 | chr20 | GO:0007179 | Not Cancer Driver | No | 20 | 0.129 | 17 | 6 | 0.353 | 0 |
| ITGB1_ENST00000302278 | ITGB1 | P05556 | Integrin beta-1 | chr10 | GO:0007179 | Not Cancer Driver | No | 103 | 0.129 | 84 | 10 | 0.119 | 0 |
| ITGB5 | ITGB5 | P18084 | Integrin beta-5 | chr3 | GO:0007179 | Not Cancer Driver | No | 86 | 0.108 | 27 | 3 | 0.111 | 0 |
| ITGB6_ENST00000409872 | ITGB6 | P18564 | Integrin beta-6 | chr2 | GO:0007179 | Not Cancer Driver | No | 120 | 0.152 | 26 | 4 | 0.154 | 3 |
| ITGB8 | ITGB8 | P26012 | Integrin beta-8 | chr7 | GO:0007179 | Not Cancer Driver | No | 126 | 0.164 | 26 | 3 | 0.115 | 0 |
| JUN | JUN | P05412 | Transcription factor Jun | chr1 | GO:0007179 | Census | Yes | 35 | 0.106 | 281 | 25 | 0.089 | 0 |
| LEFTY1 | LEFTY1 | O75610 | Left-right determination factor 1 | chr1 | GO:0007179 | Not Cancer Driver | No | 55 | 0.15 | 65 | 8 | 0.123 | 0 |
| LPXN_ENST00000395074 | LPXN | O60711 | Leupaxin | chr11 | GO:0007179 | Not Cancer Driver | No | 43 | 0.111 | 134 | 16 | 0.119 | 0 |
| LRRC32_ENST00000404995 | LRRC32 | Q14392 | Transforming growth factor beta activator LRRC32 | chr11 | GO:0007179 | Not Cancer Driver | No | 130 | 0.196 | 28 | 4 | 0.143 | 0 |
| LTBP2 | LTBP2 | Q14767 | Latent-transforming growth factor beta-binding protein 2 | chr14 | GO:0007179 | Not Cancer Driver | No | 302 | 0.166 | 632 | 102 | 0.161 | 1 |
| LTBP3 | LTBP3 | Q9NS15 | Latent-transforming growth factor beta-binding protein 3 | chr11 | GO:0007179 | Not Cancer Driver | No | 108 | 0.083 | 356 | 22 | 0.062 | 0 |
| LTBP4 | LTBP4 | Q8N2S1 | Latent-transforming growth factor beta-binding protein 4 | chr19 | GO:0007179 | Not Cancer Driver | No | 191 | 0.118 | 432 | 42 | 0.097 | 1 |
| MAP3K7 | MAP3K7 | O43318 | Mitogen-activated protein kinase kinase kinase 7 | chr6 | GO:0007179 | Not Cancer Driver | No | 104 | 0.172 | 333 | 66 | 0.198 | 6 |
| MSTN | MSTN | O14793 | Growth/differentiation factor 8 | chr2 | GO:0007179 | Not Cancer Driver | No | 68 | 0.181 | 64 | 11 | 0.172 | 0 |
| MTMR4 | MTMR4 | Q9NYA4 | Myotubularin-related protein 4 | chr17 | GO:0007179 | Not Cancer Driver | No | 147 | 0.123 | 474 | 59 | 0.124 | 0 |
| NLK | NLK | Q9UBE8 | Serine/threonine-protein kinase NLK | chr17 | GO:0007179 | Not Cancer Driver | No | 54 | 0.102 | 152 | 20 | 0.132 | 0 |
| NODAL | NODAL | Q96S42 | Nodal homolog | chr10 | GO:0007179 | Not Cancer Driver | No | 40 | 0.115 | 34 | 8 | 0.235 | 4 |
| NRROS | NRROS | Q86YC3 | Transforming growth factor beta activator LRRC33 | chr3 | GO:0007179 | Not Cancer Driver | No | 109 | 0.158 | 8 | 1 | 0.125 | 0 |
| PARP1 | PARP1 | P09874 | Poly [ADP-ribose] polymerase 1 | chr1 | GO:0007179 | Not Cancer Driver | No | 119 | 0.117 | 320 | 34 | 0.106 | 0 |
| PML | PML | P29590 | Protein PML | chr15 | GO:0007179 | Census, Compendium | Yes | 112 | 0.127 | 312 | 34 | 0.109 | 0 |
| PSG9 | PSG9 | Q00887 | Pregnancy-specific beta-1-glycoprotein 9 | chr19 | GO:0007179 | Not Cancer Driver | No | 125 | 0.293 | 40 | 8 | 0.2 | 0 |
| PTK2_ENST00000522684 | PTK2 | Q05397 | Focal adhesion kinase 1 | chr8 | GO:0007179 | Not Cancer Driver | No | 134 | 0.127 | 425 | 55 | 0.129 | 0 |
| PTPRK_ENST00000368215 | PTPRK | Q15262 | Receptor-type tyrosine-protein phosphatase kappa | chr6 | GO:0007179 | Census, Compendium | Yes | 292 | 0.203 | 302 | 57 | 0.189 | 0 |
| PXN_ENST00000228307 | PXN | P49023 | Paxillin | chr12 | GO:0007179 | Not Cancer Driver | No | 62 | 0.105 | 341 | 24 | 0.07 | 0 |
| SIRT1 | SIRT1 | Q96EB6 | NAD-dependent protein deacetylase sirtuin-1 | chr10 | GO:0007179 | Not Cancer Driver | No | 70 | 0.094 | 435 | 31 | 0.071 | 0 |
| SKI | SKI | P12755 | Ski oncogene | chr1 | GO:0007179 | Census | Yes | 44 | 0.06 | 432 | 26 | 0.06 | 14 |
| SKIL_ENST00000259119 | SKIL | P12757 | Ski-like protein | chr3 | GO:0007179 | Not Cancer Driver | No | 77 | 0.113 | 356 | 32 | 0.09 | 0 |
| SMAD1 | SMAD1 | Q15797 | Mothers against decapentaplegic homolog 1 | chr4 | GO:0007179 | Not Cancer Driver | No | 54 | 0.116 | 161 | 22 | 0.137 | 0 |
| SMAD2_ENST00000402690 | SMAD2 | Q15796 | Mothers against decapentaplegic homolog 2 | chr18 | GO:0007179 | Census, Compendium | Yes | 79 | 0.169 | 137 | 12 | 0.088 | 0 |
| SMAD3 | SMAD3 | P84022 | Mothers against decapentaplegic homolog 3 | chr15 | GO:0007179 | Census, Compendium | Yes | 97 | 0.228 | 111 | 19 | 0.171 | 5 |
| SMAD4_ENST00000398417 | SMAD4 | Q13485 | Mothers against decapentaplegic homolog 4 | chr18 | GO:0007179 | Census, Compendium | Yes | 198 | 0.359 | 195 | 17 | 0.087 | 8 |
| SMAD5_ENST00000509297 | SMAD5 | Q99717 | Mothers against decapentaplegic homolog 5 | chr5 | GO:0007179 | Not Cancer Driver | No | 44 | 0.095 | 172 | 11 | 0.064 | 0 |
| SMAD6 | SMAD6 | O43541 | Mothers against decapentaplegic homolog 6 | chr15 | GO:0007179 | Not Cancer Driver | No | 38 | 0.077 | 248 | 7 | 0.028 | 7 |
| SMAD7 | SMAD7 | O15105 | Mothers against decapentaplegic homolog 7 | chr18 | GO:0007179 | Not Cancer Driver | No | 40 | 0.094 | 139 | 0 | 0.0 | 0 |
| SMAD9 | SMAD9 | O15198 | Mothers against decapentaplegic homolog 9 | chr13 | GO:0007179 | Not Cancer Driver | No | 79 | 0.169 | 132 | 14 | 0.106 | 1 |
| SPI1_ENST00000378538 | SPI1 | P17947 | Transcription factor PU.1 | chr11 | GO:0007179 | Not Cancer Driver | No | 46 | 0.17 | 187 | 34 | 0.182 | 0 |
| SRC_ENST00000358208 | SRC | P12931 | Proto-oncogene tyrosine-protein kinase Src | chr20 | GO:0007179 | Census | Yes | 53 | 0.099 | 130 | 11 | 0.085 | 1 |
| STAT3 | STAT3 | P40763 | Signal transducer and activator of transcription 3 | chr17 | GO:0007179 | Census, Compendium | Yes | 110 | 0.143 | 152 | 15 | 0.099 | 19 |
| TAB1 | TAB1 | Q15750 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 | chr22 | GO:0007179 | Not Cancer Driver | No | 81 | 0.161 | 232 | 34 | 0.147 | 0 |
| TGFB1 | TGFB1 | P01137 | Transforming growth factor beta-1 proprotein | chr19 | GO:0007179 | Not Cancer Driver | No | 41 | 0.105 | 41 | 4 | 0.098 | 10 |
| TGFB2_ENST00000366930 | TGFB2 | P61812 | Transforming growth factor beta-2 proprotein | chr1 | GO:0007179 | Not Cancer Driver | No | 63 | 0.152 | 47 | 8 | 0.17 | 3 |
| TGFB3 | TGFB3 | P10600 | Transforming growth factor beta-3 proprotein | chr14 | GO:0007179 | Not Cancer Driver | No | 45 | 0.109 | 96 | 14 | 0.146 | 1 |
| TGFBR1_ENST00000374994 | TGFBR1 | P36897 | TGF-beta receptor type-1 | chr9 | GO:0007179 | Not Cancer Driver | No | 86 | 0.171 | 23 | 3 | 0.13 | 15 |
| TGFBR2_ENST00000295754 | TGFBR2 | P37173 | TGF-beta receptor type-2 | chr3 | GO:0007179 | Census, Compendium | Yes | 106 | 0.187 | 60 | 16 | 0.267 | 25 |
| TGFBR3_ENST00000525962 | TGFBR3 | Q03167 | Transforming growth factor beta receptor type 3 | chr1 | GO:0007179 | Not Cancer Driver | No | 129 | 0.152 | 268 | 41 | 0.153 | 0 |
| TGFBRAP1 | TGFBRAP1 | Q8WUH2 | Transforming growth factor-beta receptor-associated protein 1 | chr2 | GO:0007179 | Not Cancer Driver | No | 127 | 0.148 | 37 | 8 | 0.216 | 0 |
| TP53_ENST00000445888 | TP53 | P04637 | Cellular tumor antigen p53 | chr17 | GO:0007179 | Census, Compendium | Yes | 2891 | 7.356 | 282 | 1466 | 5.199 | 83 |
| TWSG1 | TWSG1 | Q9GZX9 | Twisted gastrulation protein homolog 1 | chr18 | GO:0007179 | Not Cancer Driver | No | 27 | 0.121 | 19 | 3 | 0.158 | 0 |
| USP15 | USP15 | Q9Y4E8 | Ubiquitin carboxyl-terminal hydrolase 15 | chr12 | GO:0007179 | Not Cancer Driver | No | 136 | 0.139 | 259 | 39 | 0.151 | 0 |
| USP9X_ENST00000378308 | USP9X | Q93008 | Probable ubiquitin carboxyl-terminal hydrolase FAF-X | chrX | GO:0007179 | Census, Compendium | Yes | 339 | 0.133 | 405 | 51 | 0.126 | 1 |
| USP9Y | USP9Y | O00507 | Probable ubiquitin carboxyl-terminal hydrolase FAF-Y | chrY | GO:0007179 | Not Cancer Driver | No | 83 | 0.032 | 349 | 6 | 0.017 | 0 |
| WFIKKN2 | WFIKKN2 | Q8TEU8 | WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 | chr17 | GO:0007179 | Not Cancer Driver | No | 114 | 0.198 | 94 | 32 | 0.34 | 0 |
| ZFYVE9 | ZFYVE9 | O95405 | Zinc finger FYVE domain-containing protein 9 | chr1 | GO:0007179 | Not Cancer Driver | No | 162 | 0.114 | 668 | 83 | 0.124 | 0 |
| ZMIZ1 | ZMIZ1 | Q9ULJ6 | Zinc finger MIZ domain-containing protein 1 | chr10 | GO:0007179 | Not Cancer Driver | No | 148 | 0.139 | 762 | 111 | 0.146 | 5 |
| ZMIZ2_ENST00000441627 | ZMIZ2 | Q8NF64 | Zinc finger MIZ domain-containing protein 2 | chr7 | GO:0007179 | Not Cancer Driver | No | 107 | 0.116 | 672 | 77 | 0.115 | 0 |
| ZYX | ZYX | Q15942 | Zyxin | chr7 | GO:0007179 | Not Cancer Driver | No | 83 | 0.145 | 385 | 52 | 0.135 | 0 |