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Total number of protein in "GO:0006520" GO term:  261

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
AADAT_ENST00000515480 AADAT Q8N5Z0 Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial chr4 GO:0006520 Not Cancer Driver No 48 0.113 71 10 0.141 0
AARS AARS1 P49588 Alanine--tRNA ligase, cytoplasmic chr16 GO:0006520 Not Cancer Driver No 97 0.1 140 14 0.1 5
AARS2 AARS2 Q5JTZ9 Alanine--tRNA ligase, mitochondrial chr6 GO:0006520 Not Cancer Driver No 123 0.125 203 25 0.123 5
AARSD1 AARSD1 Q9BTE6 Alanyl-tRNA editing protein Aarsd1 chr17 GO:0006520 Not Cancer Driver No 40 0.097 157 20 0.127 0
AASDH AASDH Q4L235 Beta-alanine-activating enzyme chr4 GO:0006520 Not Cancer Driver No 130 0.118 37 5 0.135 0
AASDHPPT AASDHPPT Q9NRN7 L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase chr11 GO:0006520 Not Cancer Driver No 52 0.168 27 2 0.074 0
AASS AASS Q9UDR5 Alpha-aminoadipic semialdehyde synthase, mitochondrial chr7 GO:0006520 Not Cancer Driver No 161 0.174 18 3 0.167 0
ABAT_ENST00000268251 ABAT P80404 4-aminobutyrate aminotransferase, mitochondrial chr16 GO:0006520 Not Cancer Driver No 84 0.168 28 5 0.179 1
AC068533.4 AC068533.4 H7C0S8 Argininosuccinate lyase (Fragment) chr7 GO:0006520 Not Cancer Driver No 42 0.137 66 3 0.045 0
ACAD8 ACAD8 Q9UKU7 Isobutyryl-CoA dehydrogenase, mitochondrial chr11 GO:0006520 Not Cancer Driver No 55 0.133 13 1 0.077 9
ACADSB ACADSB P45954 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial chr10 GO:0006520 Not Cancer Driver No 59 0.137 16 3 0.188 1
ACAT1 ACAT1 P24752 Acetyl-CoA acetyltransferase, mitochondrial chr11 GO:0006520 Not Cancer Driver No 45 0.105 32 1 0.031 10
ACCS ACCS Q96QU6 1-aminocyclopropane-1-carboxylate synthase-like protein 1 chr11 GO:0006520 Not Cancer Driver No 79 0.158 74 8 0.108 0
ACCSL ACCSL Q4AC99 Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2 chr11 GO:0006520 Not Cancer Driver No 99 0.174 74 10 0.135 0
ACMSD ACMSD Q8TDX5 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase chr2 GO:0006520 Not Cancer Driver No 65 0.193 9 2 0.222 0
ACY1 ACY1 Q03154 Aminoacylase-1 chr3 GO:0006520 Not Cancer Driver No 49 0.12 48 6 0.125 7
ADHFE1 ADHFE1 Q8IWW8 Hydroxyacid-oxoacid transhydrogenase, mitochondrial chr8 GO:0006520 Not Cancer Driver No 63 0.135 37 8 0.216 0
ADI1 ADI1 Q9BV57 Acireductone dioxygenase chr2 GO:0006520 Not Cancer Driver No 27 0.151 23 1 0.043 0
ADSS ADSS2 P30520 Adenylosuccinate synthetase isozyme 2 chr1 GO:0006520 Not Cancer Driver No 49 0.107 48 4 0.083 0
AFMID_ENST00000409257 AFMID Q63HM1 Kynurenine formamidase chr17 GO:0006520 Not Cancer Driver No 46 0.152 12 1 0.083 0
AGMAT AGMAT Q9BSE5 Agmatinase, mitochondrial chr1 GO:0006520 Not Cancer Driver No 53 0.151 106 10 0.094 0
AGXT AGXT P21549 Alanine--glyoxylate aminotransferase chr2 GO:0006520 Not Cancer Driver No 56 0.143 20 0 0.0 40
AGXT2 AGXT2 Q9BYV1 Alanine--glyoxylate aminotransferase 2, mitochondrial chr5 GO:0006520 Not Cancer Driver No 136 0.265 11 5 0.455 0
ALDH18A1 ALDH18A1 P54886 Delta-1-pyrroline-5-carboxylate synthase chr10 GO:0006520 Not Cancer Driver No 94 0.118 86 13 0.151 15
ALDH1A1 ALDH1A1 P00352 Aldehyde dehydrogenase 1A1 chr9 GO:0006520 Not Cancer Driver No 65 0.13 29 3 0.103 0
ALDH4A1 ALDH4A1 P30038 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial chr1 GO:0006520 Not Cancer Driver No 63 0.112 46 9 0.196 1
ALDH5A1_ENST00000357578 ALDH5A1 P51649 Succinate-semialdehyde dehydrogenase, mitochondrial chr6 GO:0006520 Not Cancer Driver No 64 0.12 31 7 0.226 12
ALDH6A1 ALDH6A1 Q02252 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial chr14 GO:0006520 Not Cancer Driver No 54 0.101 83 11 0.133 1
ALDH8A1 ALDH8A1 Q9H2A2 2-aminomuconic semialdehyde dehydrogenase chr6 GO:0006520 Not Cancer Driver No 107 0.22 40 6 0.15 0
AMDHD1 AMDHD1 Q96NU7 Probable imidazolonepropionase chr12 GO:0006520 Not Cancer Driver No 72 0.169 23 5 0.217 0
AMT AMT P48728 Aminomethyltransferase, mitochondrial chr3 GO:0006520 Not Cancer Driver No 37 0.092 33 6 0.182 11
APIP APIP Q96GX9 Methylthioribulose-1-phosphate dehydratase chr11 GO:0006520 Not Cancer Driver No 24 0.099 26 1 0.038 0
ARG1_ENST00000368087 ARG1 P05089 Arginase-1 chr6 GO:0006520 Not Cancer Driver No 41 0.127 83 12 0.145 9
ARG2 ARG2 P78540 Arginase-2, mitochondrial chr14 GO:0006520 Not Cancer Driver No 25 0.071 58 3 0.052 0
ARHGAP11B ARHGAP11B Q3KRB8 Inactive Rho GTPase-activating protein 11B chr15 GO:0006520 Not Cancer Driver No 20 0.075 17 1 0.059 0
ART4 ART4 Q93070 Ecto-ADP-ribosyltransferase 4 chr12 GO:0006520 Not Cancer Driver No 45 0.143 0 0 0.0 0
ASL_ENST00000395332 ASL P04424 Argininosuccinate lyase chr7 GO:0006520 Not Cancer Driver No 77 0.166 36 2 0.056 63
ASNSD1 ASNSD1 Q9NWL6 Asparagine synthetase domain-containing protein 1 chr2 GO:0006520 Not Cancer Driver No 83 0.129 42 9 0.214 0
ASNS_ENST00000394308 ASNS P08243 Asparagine synthetase [glutamine-hydrolyzing] chr7 GO:0006520 Not Cancer Driver No 81 0.144 11 0 0.0 3
ASPA ASPA P45381 Aspartoacylase chr17 GO:0006520 Not Cancer Driver No 58 0.185 3 0 0.0 42
ASPG ASPG Q86U10 60 kDa lysophospholipase chr14 GO:0006520 Not Cancer Driver No 68 0.119 76 13 0.171 0
ASRGL1_ENST00000301776 ASRGL1 Q7L266 Isoaspartyl peptidase/L-asparaginase chr11 GO:0006520 Not Cancer Driver No 43 0.14 74 12 0.162 0
ASS1_ENST00000352480 ASS1 P00966 Argininosuccinate synthase chr9 GO:0006520 Not Cancer Driver No 65 0.158 63 8 0.127 86
ATF4_ENST00000404241 ATF4 P18848 Cyclic AMP-dependent transcription factor ATF-4 chr22 GO:0006520 Not Cancer Driver No 53 0.151 259 38 0.147 0
ATP7A ATP7A Q04656 Copper-transporting ATPase 1 chrX GO:0006520 Not Cancer Driver No 228 0.152 171 46 0.269 52
AUH AUH Q13825 Methylglutaconyl-CoA hydratase, mitochondrial chr9 GO:0006520 Not Cancer Driver No 34 0.1 29 0 0.0 1
AZIN1 AZIN1 O14977 Antizyme inhibitor 1 chr8 GO:0006520 Not Cancer Driver No 39 0.087 10 2 0.2 0
AZIN2_ENST00000294517 AZIN2 Q96A70 Antizyme inhibitor 2 chr1 GO:0006520 Not Cancer Driver No 51 0.111 14 0 0.0 0
BAAT_ENST00000395051 BAAT Q14032 Bile acid-CoA:amino acid N-acyltransferase chr9 GO:0006520 Not Cancer Driver No 88 0.211 10 4 0.4 1
BCAT1_ENST00000261192 BCAT1 P54687 Branched-chain-amino-acid aminotransferase, cytosolic chr12 GO:0006520 Not Cancer Driver No 67 0.174 8 2 0.25 0
BCAT2 BCAT2 O15382 Branched-chain-amino-acid aminotransferase, mitochondrial chr19 GO:0006520 Not Cancer Driver No 54 0.138 19 0 0.0 2
BCKDHA BCKDHA P12694 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial chr19 GO:0006520 Not Cancer Driver No 53 0.119 121 18 0.149 11
BCKDHB BCKDHB P21953 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial chr6 GO:0006520 Not Cancer Driver No 47 0.12 23 3 0.13 5
BCKDK BCKDK O14874 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial chr16 GO:0006520 Not Cancer Driver No 62 0.15 39 3 0.077 3
BHMT BHMT Q93088 Betaine--homocysteine S-methyltransferase 1 chr5 GO:0006520 Not Cancer Driver No 78 0.192 93 12 0.129 0
BHMT2 BHMT2 Q9H2M3 S-methylmethionine--homocysteine S-methyltransferase BHMT2 chr5 GO:0006520 Not Cancer Driver No 54 0.149 30 4 0.133 0
BLMH BLMH Q13867 Bleomycin hydrolase chr17 GO:0006520 Not Cancer Driver No 54 0.119 15 1 0.067 0
BLOC1S6_ENST00000220531 BLOC1S6 Q9UL45 Biogenesis of lysosome-related organelles complex 1 subunit 6 chr15 GO:0006520 Not Cancer Driver No 12 0.07 111 11 0.099 0
BPHL BPHL Q86WA6 Valacyclovir hydrolase chr6 GO:0006520 Not Cancer Driver No 35 0.12 12 1 0.083 0
CAD CAD P27708 CAD protein chr2 GO:0006520 Not Cancer Driver No 287 0.129 368 52 0.141 1
CARNMT1 CARNMT1 Q8N4J0 Carnosine N-methyltransferase chr9 GO:0006520 Not Cancer Driver No 42 0.103 75 1 0.013 0
CARNS1_ENST00000307823 CARNS1 A5YM72 Carnosine synthase 1 chr11 GO:0006520 Not Cancer Driver No 74 0.089 42 4 0.095 0
CARS2 CARS2 Q9HA77 Probable cysteine--tRNA ligase, mitochondrial chr13 GO:0006520 Not Cancer Driver No 51 0.09 87 8 0.092 1
CARS_ENST00000397111 CARS1 P49589 Cysteine--tRNA ligase, cytoplasmic chr11 GO:0006520 Not Cancer Driver No 97 0.13 184 35 0.19 3
CBS_ENST00000359624 CBS P35520 Cystathionine beta-synthase chr21 GO:0006520 Not Cancer Driver No 61 0.111 160 19 0.119 103
CDO1 CDO1 Q16878 Cysteine dioxygenase type 1 chr5 GO:0006520 Not Cancer Driver No 37 0.185 43 4 0.093 0
CPS1_ENST00000233072 CPS1 P31327 Carbamoyl-phosphate synthase [ammonia], mitochondrial chr2 GO:0006520 Not Cancer Driver No 368 0.245 73 22 0.301 140
CRYM CRYM Q14894 Ketimine reductase mu-crystallin chr16 GO:0006520 Not Cancer Driver No 34 0.108 10 0 0.0 1
CSAD_ENST00000453446 CSAD Q9Y600 Cysteine sulfinic acid decarboxylase chr12 GO:0006520 Not Cancer Driver No 73 0.148 23 8 0.348 0
CTH CTH P32929 Cystathionine gamma-lyase chr1 GO:0006520 Not Cancer Driver No 45 0.111 49 6 0.122 2
CTNS_ENST00000046640 CTNS O60931 Cystinosin chr17 GO:0006520 Not Cancer Driver No 34 0.093 0 0 0.0 31
CTPS1 CTPS1 P17812 CTP synthase 1 chr1 GO:0006520 Not Cancer Driver No 70 0.118 83 10 0.12 0
CTPS2_ENST00000380241 CTPS2 Q9NRF8 CTP synthase 2 chrX GO:0006520 Not Cancer Driver No 57 0.097 65 9 0.138 0
DALRD3 DALRD3 Q5D0E6 DALR anticodon-binding domain-containing protein 3 chr3 GO:0006520 Not Cancer Driver No 49 0.09 40 4 0.1 0
DAO DAO P14920 D-amino-acid oxidase chr12 GO:0006520 Not Cancer Driver No 103 0.297 28 13 0.464 0
DARS DARS1 P14868 Aspartate--tRNA ligase, cytoplasmic chr2 GO:0006520 Not Cancer Driver No 55 0.11 110 21 0.191 8
DARS2 DARS2 Q6PI48 Aspartate--tRNA ligase, mitochondrial chr1 GO:0006520 Not Cancer Driver No 63 0.098 91 11 0.121 11
DBT DBT P11182 Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial chr1 GO:0006520 Not Cancer Driver No 64 0.133 81 11 0.136 3
DCT_ENST00000377028 DCT P40126 L-dopachrome tautomerase chr13 GO:0006520 Not Cancer Driver No 113 0.218 19 4 0.211 2
DDAH1 DDAH1 O94760 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 chr1 GO:0006520 Not Cancer Driver No 28 0.098 44 3 0.068 0
DDAH2_ENST00000375787 DDAH2 O95865 N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 chr6 GO:0006520 Not Cancer Driver No 24 0.084 96 6 0.062 0
DDC DDC P20711 Aromatic-L-amino-acid decarboxylase chr7 GO:0006520 Not Cancer Driver No 98 0.204 5 0 0.0 9
DGLUCY_ENST00000428926 DGLUCY Q7Z3D6 D-glutamate cyclase, mitochondrial chr14 GO:0006520 Not Cancer Driver No 78 0.127 120 14 0.117 0
DHFR DHFR P00374 Dihydrofolate reductase chr5 GO:0006520 Not Cancer Driver No 16 0.086 12 2 0.167 2
DHFR2_ENST00000314636 DHFR2 Q86XF0 Dihydrofolate reductase 2, mitochondrial chr3 GO:0006520 Not Cancer Driver No 25 0.134 20 0 0.0 0
DIO1_ENST00000613679 DIO1 P49895 Type I iodothyronine deiodinase chr1 GO:0006520 Not Cancer Driver No 28 0.112 0 0 0.0 0
DLD DLD P09622 Dihydrolipoyl dehydrogenase, mitochondrial chr7 GO:0006520 Not Cancer Driver No 67 0.132 17 0 0.0 10
DLST DLST P36957 Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial chr14 GO:0006520 Not Cancer Driver No 53 0.117 190 32 0.168 1
DPEP1 DPEP1 P16444 Dipeptidase 1 chr16 GO:0006520 Not Cancer Driver No 54 0.131 41 6 0.146 0
DPYD DPYD Q12882 Dihydropyrimidine dehydrogenase [NADP(+)] chr1 GO:0006520 Not Cancer Driver No 303 0.296 77 23 0.299 3
EARS2_ENST00000449606 EARS2 Q5JPH6 Probable glutamate--tRNA ligase, mitochondrial chr16 GO:0006520 Not Cancer Driver No 56 0.107 99 14 0.141 14
ECHS1 ECHS1 P30084 Enoyl-CoA hydratase, mitochondrial chr10 GO:0006520 Not Cancer Driver No 51 0.176 7 1 0.143 14
ENOPH1 ENOPH1 Q9UHY7 Enolase-phosphatase E1 chr4 GO:0006520 Not Cancer Driver No 35 0.134 14 2 0.143 0
EPRS EPRS1 P07814 Bifunctional glutamate/proline--tRNA ligase chr1 GO:0006520 Not Cancer Driver No 204 0.135 372 62 0.167 1
FAH_ENST00000561421 FAH P16930 Fumarylacetoacetase chr15 GO:0006520 Not Cancer Driver No 50 0.119 41 10 0.244 20
FARS2_ENST00000274680 FARS2 O95363 Phenylalanine--tRNA ligase, mitochondrial chr6 GO:0006520 Not Cancer Driver No 66 0.146 73 17 0.233 4
FARSA FARSA Q9Y285 Phenylalanine--tRNA ligase alpha subunit chr19 GO:0006520 Not Cancer Driver No 75 0.148 120 25 0.208 0
FARSB FARSB Q9NSD9 Phenylalanine--tRNA ligase beta subunit chr2 GO:0006520 Not Cancer Driver No 71 0.121 0 0 0.0 8
FN3K FN3K Q9H479 Fructosamine-3-kinase chr17 GO:0006520 Not Cancer Driver No 36 0.117 40 3 0.075 0
FPGS FPGS Q05932 Folylpolyglutamate synthase, mitochondrial chr9 GO:0006520 Not Cancer Driver No 68 0.116 141 18 0.128 0
FTCD_ENST00000291670 FTCD O95954 Formimidoyltransferase-cyclodeaminase chr21 GO:0006520 Not Cancer Driver No 86 0.159 44 36 0.818 2
GAD1 GAD1 Q99259 Glutamate decarboxylase 1 chr2 GO:0006520 Not Cancer Driver No 113 0.19 55 5 0.091 1
GAD2_ENST00000259271 GAD2 Q05329 Glutamate decarboxylase 2 chr10 GO:0006520 Not Cancer Driver No 148 0.253 37 7 0.189 0
GARS GARS1 P41250 Glycine--tRNA ligase chr7 GO:0006520 Not Cancer Driver No 61 0.083 75 9 0.12 17
GART_ENST00000381815 GART P22102 Trifunctional purine biosynthetic protein adenosine-3 chr21 GO:0006520 Not Cancer Driver No 96 0.095 50 6 0.12 0
GATB GATB O75879 Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial chr4 GO:0006520 Not Cancer Driver No 79 0.142 138 26 0.188 0
GATC GATC O43716 Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial chr12 GO:0006520 Not Cancer Driver No 18 0.132 27 4 0.148 1
GCAT_ENST00000248924 GCAT O75600 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial chr22 GO:0006520 Not Cancer Driver No 59 0.141 2 0 0.0 0
GCDH_ENST00000591470 GCDH Q92947 Glutaryl-CoA dehydrogenase, mitochondrial chr19 GO:0006520 Not Cancer Driver No 57 0.13 37 5 0.135 58
GCLC GCLC P48506 Glutamate--cysteine ligase catalytic subunit chr6 GO:0006520 Not Cancer Driver No 73 0.115 167 18 0.108 3
GCLM GCLM P48507 Glutamate--cysteine ligase regulatory subunit chr1 GO:0006520 Not Cancer Driver No 32 0.117 31 3 0.097 0
GCSH GCSH P23434 Glycine cleavage system H protein, mitochondrial chr16 GO:0006520 Not Cancer Driver No 15 0.087 25 0 0.0 0
GFPT1 GFPT1 Q06210 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 chr2 GO:0006520 Not Cancer Driver No 81 0.116 75 8 0.107 13
GFPT2 GFPT2 O94808 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 chr5 GO:0006520 Not Cancer Driver No 121 0.177 42 8 0.19 0
GGT1_ENST00000248923 GGT1 P19440 Glutathione hydrolase 1 proenzyme chr22 GO:0006520 Not Cancer Driver No 83 0.146 88 14 0.159 0
GGT5_ENST00000327365 GGT5 P36269 Glutathione hydrolase 5 proenzyme chr22 GO:0006520 Not Cancer Driver No 99 0.169 122 27 0.221 0
GLDC GLDC P23378 Glycine dehydrogenase (decarboxylating), mitochondrial chr9 GO:0006520 Not Cancer Driver No 152 0.149 112 7 0.062 22
GLS GLS O94925 Glutaminase kidney isoform, mitochondrial chr2 GO:0006520 Not Cancer Driver No 71 0.106 187 9 0.048 3
GLS2 GLS2 Q9UI32 Glutaminase liver isoform, mitochondrial chr12 GO:0006520 Not Cancer Driver No 57 0.095 108 9 0.083 0
GLUD1 GLUD1 P00367 Glutamate dehydrogenase 1, mitochondrial chr10 GO:0006520 Not Cancer Driver No 50 0.09 107 14 0.131 13
GLUD2 GLUD2 P49448 Glutamate dehydrogenase 2, mitochondrial chrX GO:0006520 Not Cancer Driver No 145 0.26 117 37 0.316 0
GLUL_ENST00000331872 GLUL P15104 Glutamine synthetase chr1 GO:0006520 Not Cancer Driver No 66 0.177 104 21 0.202 2
GLYAT GLYAT Q6IB77 Glycine N-acyltransferase chr11 GO:0006520 Not Cancer Driver No 75 0.253 9 2 0.222 0
GLYATL1B GLYATL1B A0A0U1RQE8 Putative glycine N-acyltransferase-like protein 1B chr11 GO:0006520 Not Cancer Driver No 4 0.013 17 0 0.0 0
GLYATL1_ENST00000612196 GLYATL1 Q969I3 Glycine N-acyltransferase-like protein 1 chr11 GO:0006520 Not Cancer Driver No 98 0.325 30 22 0.733 0
GMPS GMPS P49915 GMP synthase [glutamine-hydrolyzing] chr3 GO:0006520 Census, Compendium Yes 88 0.127 76 10 0.132 0
GNMT GNMT Q14749 Glycine N-methyltransferase chr6 GO:0006520 Not Cancer Driver No 25 0.085 0 0 0.0 3
GOT1 GOT1 P17174 Aspartate aminotransferase, cytoplasmic chr10 GO:0006520 Not Cancer Driver No 56 0.136 35 5 0.143 0
GOT1L1 GOT1L1 Q8NHS2 Putative aspartate aminotransferase, cytoplasmic 2 chr8 GO:0006520 Not Cancer Driver No 62 0.147 0 0 0.0 0
GOT2 GOT2 P00505 Aspartate aminotransferase, mitochondrial chr16 GO:0006520 Not Cancer Driver No 61 0.142 25 3 0.12 1
GPT2 GPT2 Q8TD30 Alanine aminotransferase 2 chr16 GO:0006520 Not Cancer Driver No 61 0.117 68 5 0.074 1
GPT_ENST00000528431 GPT P24298 Alanine aminotransferase 1 chr8 GO:0006520 Not Cancer Driver No 52 0.105 51 9 0.176 0
GSS_ENST00000216951 GSS P48637 Glutathione synthetase chr20 GO:0006520 Not Cancer Driver No 61 0.129 49 6 0.122 14
GSTZ1 GSTZ1 O43708 Maleylacetoacetate isomerase chr14 GO:0006520 Not Cancer Driver No 30 0.139 19 2 0.105 2
HAAO HAAO P46952 3-hydroxyanthranilate 3,4-dioxygenase chr2 GO:0006520 Not Cancer Driver No 40 0.14 30 2 0.067 0
HAL HAL P42357 Histidine ammonia-lyase chr12 GO:0006520 Not Cancer Driver No 98 0.149 34 6 0.176 4
HARS2_ENST00000642231 HARS2 P49590 Histidine--tRNA ligase, mitochondrial chr5 GO:0006520 Not Cancer Driver No 48 0.095 34 4 0.118 2
HARS_ENST00000644191 HARS1 P12081 Histidine--tRNA ligase, cytoplasmic chr5 GO:0006520 Not Cancer Driver No 65 0.128 17 2 0.118 7
HDC HDC P19113 Histidine decarboxylase chr15 GO:0006520 Not Cancer Driver No 163 0.246 96 24 0.25 0
HGD HGD Q93099 Homogentisate 1,2-dioxygenase chr3 GO:0006520 Not Cancer Driver No 75 0.169 78 23 0.295 68
HIBADH HIBADH P31937 3-hydroxyisobutyrate dehydrogenase, mitochondrial chr7 GO:0006520 Not Cancer Driver No 28 0.083 7 2 0.286 0
HIBCH HIBCH Q6NVY1 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial chr2 GO:0006520 Not Cancer Driver No 42 0.109 26 0 0.0 1
HMGCL HMGCL P35914 Hydroxymethylglutaryl-CoA lyase, mitochondrial chr1 GO:0006520 Not Cancer Driver No 17 0.052 8 2 0.25 19
HMGCLL1 HMGCLL1 Q8TB92 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic chr6 GO:0006520 Not Cancer Driver No 113 0.305 2 1 0.5 0
HNF4A HNF4A P41235 Hepatocyte nuclear factor 4-alpha chr20 GO:0006520 Not Cancer Driver No 135 0.285 127 48 0.378 5
HNMT HNMT P50135 Histamine N-methyltransferase chr2 GO:0006520 Not Cancer Driver No 40 0.137 7 0 0.0 2
HOGA1 HOGA1 Q86XE5 4-hydroxy-2-oxoglutarate aldolase, mitochondrial chr10 GO:0006520 Not Cancer Driver No 34 0.104 2 0 0.0 2
HPD HPD P32754 4-hydroxyphenylpyruvate dioxygenase chr12 GO:0006520 Not Cancer Driver No 61 0.155 40 9 0.225 3
HSD17B10 HSD17B10 Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 chrX GO:0006520 Not Cancer Driver No 27 0.103 15 3 0.2 11
HYKK_ENST00000388988 HYKK A2RU49 Hydroxylysine kinase chr15 GO:0006520 Not Cancer Driver No 38 0.102 30 3 0.1 0
IARS IARS1 P41252 Isoleucine--tRNA ligase, cytoplasmic chr9 GO:0006520 Not Cancer Driver No 130 0.103 28 4 0.143 4
IARS2 IARS2 Q9NSE4 Isoleucine--tRNA ligase, mitochondrial chr1 GO:0006520 Not Cancer Driver No 149 0.147 145 22 0.152 0
ICMT ICMT O60725 Protein-S-isoprenylcysteine O-methyltransferase chr1 GO:0006520 Not Cancer Driver No 24 0.085 0 0 0.0 0
IDO1_ENST00000522495 IDO1 P14902 Indoleamine 2,3-dioxygenase 1 chr8 GO:0006520 Not Cancer Driver No 82 0.203 41 8 0.195 0
IDO2 IDO2 Q6ZQW0 Indoleamine 2,3-dioxygenase 2 chr8 GO:0006520 Not Cancer Driver No 93 0.221 35 5 0.143 0
IL4I1_ENST00000391826 IL4I1 Q96RQ9 L-amino-acid oxidase chr19 GO:0006520 Not Cancer Driver No 65 0.115 136 14 0.103 0
ILVBL ILVBL A1L0T0 2-hydroxyacyl-CoA lyase 2 chr19 GO:0006520 Not Cancer Driver No 86 0.136 30 1 0.033 0
IVD IVD P26440 Isovaleryl-CoA dehydrogenase, mitochondrial chr15 GO:0006520 Not Cancer Driver No 46 0.108 8 0 0.0 14
KARS_ENST00000302445 KARS1 Q15046 Lysine--tRNA ligase chr16 GO:0006520 Not Cancer Driver No 88 0.147 160 15 0.094 12
KMO KMO O15229 Kynurenine 3-monooxygenase chr1 GO:0006520 Not Cancer Driver No 77 0.158 0 0 0.0 0
KYAT1_ENST00000302586 KYAT1 Q16773 Kynurenine--oxoglutarate transaminase 1 chr9 GO:0006520 Not Cancer Driver No 56 0.133 5 1 0.2 0
KYAT3 KYAT3 Q6YP21 Kynurenine--oxoglutarate transaminase 3 chr1 GO:0006520 Not Cancer Driver No 67 0.148 0 0 0.0 0
KYNU_ENST00000409512 KYNU Q16719 Kynureninase chr2 GO:0006520 Not Cancer Driver No 103 0.222 20 5 0.25 1
LARS LARS1 Q9P2J5 Leucine--tRNA ligase, cytoplasmic chr5 GO:0006520 Not Cancer Driver No 133 0.113 97 10 0.103 1
LARS2_ENST00000645846 LARS2 Q15031 Leucine--tRNA ligase, mitochondrial chr3 GO:0006520 Not Cancer Driver No 74 0.082 80 8 0.1 3
LGSN LGSN Q5TDP6 Lengsin chr6 GO:0006520 Not Cancer Driver No 136 0.267 91 22 0.242 0
LRRC47 LRRC47 Q8N1G4 Leucine-rich repeat-containing protein 47 chr1 GO:0006520 Not Cancer Driver No 65 0.111 291 30 0.103 0
MARS MARS1 P56192 Methionine--tRNA ligase, cytoplasmic chr12 GO:0006520 Not Cancer Driver No 91 0.101 151 16 0.106 8
MARS2 MARS2 Q96GW9 Methionine--tRNA ligase, mitochondrial chr2 GO:0006520 Not Cancer Driver No 75 0.126 34 6 0.176 1
MAT1A MAT1A Q00266 S-adenosylmethionine synthase isoform type-1 chr10 GO:0006520 Not Cancer Driver No 74 0.187 15 0 0.0 12
MCCC1 MCCC1 Q96RQ3 Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial chr3 GO:0006520 Not Cancer Driver No 94 0.13 162 17 0.105 33
MCCC2 MCCC2 Q9HCC0 Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial chr5 GO:0006520 Not Cancer Driver No 60 0.107 25 2 0.08 52
MECP2_ENST00000303391 MECP2 P51608 Methyl-CpG-binding protein 2 chrX GO:0006520 Not Cancer Driver No 75 0.154 483 74 0.153 46
MMUT MMUT P22033 Methylmalonyl-CoA mutase, mitochondrial chr6 GO:0006520 Not Cancer Driver No 107 0.143 99 11 0.111 125
MPST_ENST00000341116 MPST P25325 3-mercaptopyruvate sulfurtransferase chr22 GO:0006520 Not Cancer Driver No 20 0.067 72 8 0.111 0
MRI1 MRI1 Q9BV20 Methylthioribose-1-phosphate isomerase chr19 GO:0006520 Not Cancer Driver No 26 0.07 47 8 0.17 0
MSRA MSRA Q9UJ68 Mitochondrial peptide methionine sulfoxide reductase chr8 GO:0006520 Not Cancer Driver No 39 0.166 81 14 0.173 0
MTAP MTAP Q13126 S-methyl-5'-thioadenosine phosphorylase chr9 GO:0006520 Not Cancer Driver No 37 0.131 15 0 0.0 0
MTHFD1 MTHFD1 P11586 C-1-tetrahydrofolate synthase, cytoplasmic chr14 GO:0006520 Not Cancer Driver No 103 0.11 129 11 0.085 6
MTHFD2L MTHFD2L Q9H903 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial chr4 GO:0006520 Not Cancer Driver No 45 0.13 59 6 0.102 0
MTHFR_ENST00000376590 MTHFR P42898 Methylenetetrahydrofolate reductase chr1 GO:0006520 Not Cancer Driver No 95 0.145 125 22 0.176 53
MTHFS MTHFS P49914 5-formyltetrahydrofolate cyclo-ligase chr15 GO:0006520 Not Cancer Driver No 18 0.089 36 6 0.167 2
MTR MTR Q99707 Methionine synthase chr1 GO:0006520 Not Cancer Driver No 151 0.119 104 17 0.163 2
MTRR_ENST00000440940 MTRR Q9UBK8 Methionine synthase reductase chr5 GO:0006520 Not Cancer Driver No 101 0.145 84 13 0.155 5
NAGS NAGS Q8N159 N-acetylglutamate synthase, mitochondrial chr17 GO:0006520 Not Cancer Driver No 35 0.066 116 6 0.052 6
NARS NARS1 O43776 Asparagine--tRNA ligase, cytoplasmic chr18 GO:0006520 Not Cancer Driver No 50 0.091 103 16 0.155 4
NARS2 NARS2 Q96I59 Probable asparagine--tRNA ligase, mitochondrial chr11 GO:0006520 Not Cancer Driver No 79 0.166 22 2 0.091 3
NAT8L NAT8L Q8N9F0 N-acetylaspartate synthetase chr4 GO:0006520 Not Cancer Driver No 20 0.066 57 0 0.0 0
NIT2 NIT2 Q9NQR4 Omega-amidase NIT2 chr3 GO:0006520 Not Cancer Driver No 47 0.17 0 0 0.0 0
NOX4 NOX4 Q9NPH5 NADPH oxidase 4 chr11 GO:0006520 Not Cancer Driver No 123 0.213 0 0 0.0 0
NOXRED1 NOXRED1 Q6NXP6 NADP-dependent oxidoreductase domain-containing protein 1 chr14 GO:0006520 Not Cancer Driver No 50 0.139 4 1 0.25 0
OAT OAT P04181 Ornithine aminotransferase, mitochondrial chr10 GO:0006520 Not Cancer Driver No 52 0.118 17 0 0.0 27
ODC1_ENST00000405333 ODC1 P11926 Ornithine decarboxylase chr2 GO:0006520 Not Cancer Driver No 46 0.1 33 7 0.212 0
OTC OTC P00480 Ornithine transcarbamylase, mitochondrial chrX GO:0006520 Not Cancer Driver No 89 0.251 24 4 0.167 111
PAH PAH P00439 Phenylalanine-4-hydroxylase chr12 GO:0006520 Not Cancer Driver No 133 0.294 13 4 0.308 222
PARS2 PARS2 Q7L3T8 Probable proline--tRNA ligase, mitochondrial chr1 GO:0006520 Not Cancer Driver No 50 0.105 8 2 0.25 0
PCBD1 PCBD1 P61457 Pterin-4-alpha-carbinolamine dehydratase chr10 GO:0006520 Not Cancer Driver No 8 0.077 7 0 0.0 3
PCBD2_ENST00000254908 PCBD2 Q9H0N5 Pterin-4-alpha-carbinolamine dehydratase 2 chr5 GO:0006520 Not Cancer Driver No 6 0.046 3 0 0.0 0
PEPD PEPD P12955 Xaa-Pro dipeptidase chr19 GO:0006520 Not Cancer Driver No 53 0.108 17 2 0.118 4
PFAS PFAS O15067 Phosphoribosylformylglycinamidine synthase chr17 GO:0006520 Not Cancer Driver No 157 0.117 380 36 0.095 0
PHGDH_ENST00000641023 PHGDH O43175 D-3-phosphoglycerate dehydrogenase chr1 GO:0006520 Not Cancer Driver No 51 0.096 38 4 0.105 8
PIPOX PIPOX Q9P0Z9 Peroxisomal sarcosine oxidase chr17 GO:0006520 Not Cancer Driver No 52 0.133 21 3 0.143 0
PLOD2_ENST00000360060 PLOD2 O00469 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 chr3 GO:0006520 Not Cancer Driver No 109 0.148 17 3 0.176 4
PLOD3 PLOD3 O60568 Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 chr7 GO:0006520 Not Cancer Driver No 108 0.146 65 8 0.123 1
PM20D1 PM20D1 Q6GTS8 N-fatty-acyl-amino acid synthase/hydrolase PM20D1 chr1 GO:0006520 Not Cancer Driver No 79 0.157 42 10 0.238 0
PPAT PPAT Q06203 Amidophosphoribosyltransferase chr4 GO:0006520 Not Cancer Driver No 66 0.128 48 4 0.083 0
PRODH2 PRODH2 Q9UF12 Hydroxyproline dehydrogenase chr19 GO:0006520 Not Cancer Driver No 96 0.179 51 7 0.137 0
PRODH_ENST00000610940 PRODH O43272 Proline dehydrogenase 1, mitochondrial chr22 GO:0006520 Not Cancer Driver No 62 0.103 67 8 0.119 16
PSAT1 PSAT1 Q9Y617 Phosphoserine aminotransferase chr9 GO:0006520 Not Cancer Driver No 54 0.146 3 1 0.333 3
PSPH_ENST00000275605 PSPH P78330 Phosphoserine phosphatase chr7 GO:0006520 Not Cancer Driver No 44 0.196 21 6 0.286 3
PTS PTS Q03393 6-pyruvoyl tetrahydrobiopterin synthase chr11 GO:0006520 Not Cancer Driver No 9 0.062 22 1 0.045 24
PYCR1_ENST00000329875 PYCR1 P32322 Pyrroline-5-carboxylate reductase 1, mitochondrial chr17 GO:0006520 Not Cancer Driver No 31 0.097 67 10 0.149 9
PYCR2 PYCR2 Q96C36 Pyrroline-5-carboxylate reductase 2 chr1 GO:0006520 Not Cancer Driver No 31 0.097 41 3 0.073 2
PYCR3_ENST00000495276 PYCR3 Q53H96 Pyrroline-5-carboxylate reductase 3 chr8 GO:0006520 Not Cancer Driver No 21 0.077 11 0 0.0 0
QARS QARS1 P47897 Glutamine--tRNA ligase chr3 GO:0006520 Not Cancer Driver No 101 0.13 106 16 0.151 4
QDPR QDPR P09417 Dihydropteridine reductase chr4 GO:0006520 Not Cancer Driver No 41 0.168 25 3 0.12 16
QRSL1 QRSL1 Q9H0R6 Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial chr6 GO:0006520 Not Cancer Driver No 63 0.119 63 4 0.063 2
RARS RARS1 P54136 Arginine--tRNA ligase, cytoplasmic chr5 GO:0006520 Not Cancer Driver No 72 0.109 41 3 0.073 2
RARS2 RARS2 Q5T160 Probable arginine--tRNA ligase, mitochondrial chr6 GO:0006520 Not Cancer Driver No 88 0.152 20 1 0.05 0
RIDA RIDA P52758 2-iminobutanoate/2-iminopropanoate deaminase chr8 GO:0006520 Not Cancer Driver No 20 0.146 3 0 0.0 0
RIMKLA RIMKLA Q8IXN7 N-acetylaspartylglutamate synthase A chr1 GO:0006520 Not Cancer Driver No 65 0.166 71 17 0.239 0
RIMKLB RIMKLB Q9ULI2 Beta-citrylglutamate synthase B chr12 GO:0006520 Not Cancer Driver No 62 0.161 46 3 0.065 0
SARDH_ENST00000439388 SARDH Q9UL12 Sarcosine dehydrogenase, mitochondrial chr9 GO:0006520 Not Cancer Driver No 144 0.157 132 24 0.182 2
SARS2_ENST00000221431 SARS2 Q9NP81 Serine--tRNA ligase, mitochondrial chr19 GO:0006520 Not Cancer Driver No 64 0.124 111 14 0.126 1
SARS_ENST00000234677 SARS1 P49591 Serine--tRNA ligase, cytoplasmic chr1 GO:0006520 Not Cancer Driver No 56 0.109 83 4 0.048 1
SCLY SCLY Q96I15 Selenocysteine lyase chr2 GO:0006520 Not Cancer Driver No 49 0.11 169 11 0.065 0
SDS SDS P20132 L-serine dehydratase/L-threonine deaminase chr12 GO:0006520 Not Cancer Driver No 40 0.122 17 1 0.059 0
SDSL SDSL Q96GA7 Serine dehydratase-like chr12 GO:0006520 Not Cancer Driver No 48 0.146 15 1 0.067 0
SEPHS1 SEPHS1 P49903 Selenide, water dikinase 1 chr10 GO:0006520 Not Cancer Driver No 58 0.148 29 10 0.345 0
SEPHS2 SEPHS2 Q99611 Selenide, water dikinase 2 chr16 GO:0006520 Not Cancer Driver No 48 0.107 104 2 0.019 0
SERINC3_ENST00000255175 SERINC3 Q13530 Serine incorporator 3 chr20 GO:0006520 Not Cancer Driver No 73 0.154 38 9 0.237 0
SERINC5_ENST00000509193 SERINC5 Q86VE9 Serine incorporator 5 chr5 GO:0006520 Not Cancer Driver No 38 0.09 13 1 0.077 0
SHMT1 SHMT1 P34896 Serine hydroxymethyltransferase, cytosolic chr17 GO:0006520 Not Cancer Driver No 51 0.106 32 7 0.219 0
SHMT2 SHMT2 P34897 Serine hydroxymethyltransferase, mitochondrial chr12 GO:0006520 Not Cancer Driver No 57 0.113 58 5 0.086 1
SIRT4 SIRT4 Q9Y6E7 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial chr12 GO:0006520 Not Cancer Driver No 46 0.146 4 0 0.0 0
SLC16A2 SLC16A2 P36021 Monocarboxylate transporter 8 chrX GO:0006520 Not Cancer Driver No 84 0.156 124 12 0.097 20
SLC1A3 SLC1A3 P43003 Excitatory amino acid transporter 1 chr5 GO:0006520 Not Cancer Driver No 100 0.185 55 9 0.164 1
SLC25A12 SLC25A12 O75746 Calcium-binding mitochondrial carrier protein Aralar1 chr2 GO:0006520 Not Cancer Driver No 110 0.162 21 7 0.333 2
SLC25A13_ENST00000265631 SLC25A13 Q9UJS0 Calcium-binding mitochondrial carrier protein Aralar2 chr7 GO:0006520 Not Cancer Driver No 111 0.164 23 2 0.087 1
SLC25A21 SLC25A21 Q9BQT8 Mitochondrial 2-oxodicarboxylate carrier chr14 GO:0006520 Not Cancer Driver No 44 0.147 0 0 0.0 1
SLC25A44_ENST00000359511 SLC25A44 Q96H78 Solute carrier family 25 member 44 chr1 GO:0006520 Not Cancer Driver No 38 0.121 6 3 0.5 0
SLC39A8 SLC39A8 Q9C0K1 Metal cation symporter ZIP8 chr4 GO:0006520 Not Cancer Driver No 45 0.098 22 2 0.091 5
SMS SMS P52788 Spermine synthase chrX GO:0006520 Not Cancer Driver No 46 0.126 28 6 0.214 5
SRR SRR Q9GZT4 Serine racemase chr17 GO:0006520 Not Cancer Driver No 40 0.118 32 6 0.188 0
TARS2 TARS2 Q9BW92 Threonine--tRNA ligase, mitochondrial chr1 GO:0006520 Not Cancer Driver No 112 0.156 53 10 0.189 1
TARSL2 TARS3 A2RTX5 Threonine--tRNA ligase 2, cytoplasmic chr15 GO:0006520 Not Cancer Driver No 90 0.112 77 14 0.182 0
TARS_ENST00000265112 TARS1 P26639 Threonine--tRNA ligase 1, cytoplasmic chr5 GO:0006520 Not Cancer Driver No 112 0.155 112 22 0.196 2
TAT TAT P17735 Tyrosine aminotransferase chr16 GO:0006520 Not Cancer Driver No 102 0.225 75 21 0.28 1
TDO2 TDO2 P48775 Tryptophan 2,3-dioxygenase chr4 GO:0006520 Not Cancer Driver No 64 0.158 31 9 0.29 1
TH TH P07101 Tyrosine 3-monooxygenase chr11 GO:0006520 Not Cancer Driver No 61 0.116 149 21 0.141 38
THNSL2 THNSL2 Q86YJ6 Threonine synthase-like 2 chr2 GO:0006520 Not Cancer Driver No 73 0.151 51 3 0.059 0
TST_ENST00000249042 TST Q16762 Thiosulfate sulfurtransferase chr22 GO:0006520 Not Cancer Driver No 32 0.108 56 6 0.107 0
TYR TYR P14679 Tyrosinase chr11 GO:0006520 Not Cancer Driver No 156 0.295 52 15 0.288 111
UPB1 UPB1 Q9UBR1 Beta-ureidopropionase chr22 GO:0006520 Not Cancer Driver No 66 0.172 22 7 0.318 8
UROC1_ENST00000290868 UROC1 Q96N76 Urocanate hydratase chr3 GO:0006520 Not Cancer Driver No 151 0.223 37 9 0.243 2
VARS VARS1 P26640 Valine--tRNA ligase chr6 GO:0006520 Not Cancer Driver No 145 0.115 251 26 0.104 0
VARS2_ENST00000321897 VARS2 Q5ST30 Valine--tRNA ligase, mitochondrial chr6 GO:0006520 Not Cancer Driver No 111 0.104 253 21 0.083 3
WARS WARS1 P23381 Tryptophan--tRNA ligase, cytoplasmic chr14 GO:0006520 Not Cancer Driver No 62 0.132 90 13 0.144 1
WARS2 WARS2 Q9UGM6 Tryptophan--tRNA ligase, mitochondrial chr1 GO:0006520 Not Cancer Driver No 67 0.186 31 4 0.129 5
YARS YARS1 P54577 Tyrosine--tRNA ligase, cytoplasmic chr1 GO:0006520 Not Cancer Driver No 62 0.117 109 9 0.083 3
YARS2 YARS2 Q9Y2Z4 Tyrosine--tRNA ligase, mitochondrial chr12 GO:0006520 Not Cancer Driver No 59 0.124 62 11 0.177 2