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Total number of protein in "GO:0006302" GO term:  89

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
ABRAXAS1 ABRAXAS1 Q6UWZ7 BRCA1-A complex subunit Abraxas 1 chr4 GO:0006302 Not Cancer Driver No 38 0.093 112 15 0.134 1
ACTR5 ACTR5 Q9H9F9 Actin-related protein 5 chr20 GO:0006302 Not Cancer Driver No 63 0.104 163 23 0.141 0
ACTR8 ACTR8 Q9H981 Actin-related protein 8 chr3 GO:0006302 Not Cancer Driver No 61 0.098 239 21 0.088 0
APLF APLF Q8IW19 Aprataxin and PNK-like factor chr2 GO:0006302 Not Cancer Driver No 64 0.125 407 57 0.14 0
APTX_ENST00000379819 APTX Q7Z2E3 Aprataxin chr9 GO:0006302 Not Cancer Driver No 36 0.101 101 6 0.059 9
ATM_ENST00000452508 ATM Q13315 Serine-protein kinase ATM chr11 GO:0006302 Census, Compendium Yes 469 0.153 225 39 0.173 41
BABAM1_ENST00000601043 BABAM1 Q9NWV8 BRISC and BRCA1-A complex member 1 chr19 GO:0006302 Not Cancer Driver No 35 0.106 113 14 0.124 0
BABAM2_ENST00000342045 BABAM2 Q9NXR7 BRISC and BRCA1-A complex member 2 chr2 GO:0006302 Not Cancer Driver No 52 0.136 0 0 0.0 0
BRCA1_ENST00000357654 BRCA1 P38398 Breast cancer type 1 susceptibility protein chr17 GO:0006302 Census, Compendium Yes 224 0.12 1458 174 0.119 35
BRCA2_ENST00000544455 BRCA2 P51587 Breast cancer type 2 susceptibility protein chr13 GO:0006302 Census, Compendium Yes 457 0.134 1542 225 0.146 46
BRCC3 BRCC3 P46736 Lys-63-specific deubiquitinase BRCC36 chrX GO:0006302 Not Cancer Driver No 39 0.123 74 7 0.095 0
BRIP1 BRIP1 Q9BX63 Fanconi anemia group J protein chr17 GO:0006302 Census Yes 174 0.139 397 59 0.149 6
C19orf57_ENST00000586783 BRME1 Q0VDD7 Break repair meiotic recombinase recruitment factor 1 chr19 GO:0006302 Not Cancer Driver No 91 0.136 632 88 0.139 0
CDCA5 CDCA5 Q96FF9 Sororin chr11 GO:0006302 Not Cancer Driver No 32 0.127 211 26 0.123 0
CHEK2_ENST00000405598 CHEK2 O96017 Serine/threonine-protein kinase Chk2 chr22 GO:0006302 Census, Compendium Yes 335 0.617 157 130 0.828 13
CIB1_ENST00000328649 CIB1 Q99828 Calcium and integrin-binding protein 1 chr15 GO:0006302 Not Cancer Driver No 24 0.126 6 1 0.167 0
DDX1 DDX1 Q92499 ATP-dependent RNA helicase DDX1 chr2 GO:0006302 Not Cancer Driver No 82 0.111 91 15 0.165 0
DTX3L DTX3L Q8TDB6 E3 ubiquitin-protein ligase DTX3L chr3 GO:0006302 Not Cancer Driver No 86 0.116 260 24 0.092 0
EME1_ENST00000338165 EME1 Q96AY2 Crossover junction endonuclease EME1 chr17 GO:0006302 Not Cancer Driver No 56 0.098 296 30 0.101 0
EME2 EME2 A4GXA9 Probable crossover junction endonuclease EME2 chr16 GO:0006302 Not Cancer Driver No 28 0.074 125 7 0.056 0
ERCC6 ERCC6 Q03468 DNA excision repair protein ERCC-6 chr10 GO:0006302 Not Cancer Driver No 211 0.141 829 117 0.141 9
ERCC8 ERCC8 Q13216 DNA excision repair protein ERCC-8 chr5 GO:0006302 Not Cancer Driver No 25 0.063 53 8 0.151 7
ESCO2 ESCO2 Q56NI9 N-acetyltransferase ESCO2 chr8 GO:0006302 Not Cancer Driver No 67 0.111 292 32 0.11 1
EXD2 EXD2 Q9NVH0 Exonuclease 3'-5' domain-containing protein 2 chr14 GO:0006302 Not Cancer Driver No 58 0.093 176 15 0.085 0
EYA1_ENST00000647540 EYA1 Q99502 Eyes absent homolog 1 chr8 GO:0006302 Not Cancer Driver No 168 0.284 341 99 0.29 15
EYA3 EYA3 Q99504 Eyes absent homolog 3 chr1 GO:0006302 Not Cancer Driver No 58 0.101 310 40 0.129 0
FANCB FANCB Q8NB91 Fanconi anemia group B protein chrX GO:0006302 Not Cancer Driver No 109 0.127 24 5 0.208 0
FANCD2_ENST00000383807 FANCD2 Q9BXW9 Fanconi anemia group D2 protein chr3 GO:0006302 Census, Compendium Yes 176 0.121 181 14 0.077 3
FANCM FANCM Q8IYD8 Fanconi anemia group M protein chr14 GO:0006302 Not Cancer Driver No 268 0.131 898 128 0.143 0
FEN1 FEN1 P39748 Flap endonuclease 1 chr11 GO:0006302 Census Yes 35 0.092 111 11 0.099 0
GGN GGN Q86UU5 Gametogenetin chr19 GO:0006302 Not Cancer Driver No 91 0.14 623 89 0.143 0
H2AFX H2AX P16104 Histone H2AX chr11 GO:0006302 Not Cancer Driver No 20 0.14 68 10 0.147 0
HMCES_ENST00000502878 HMCES Q96FZ2 Abasic site processing protein HMCES chr3 GO:0006302 Not Cancer Driver No 37 0.105 131 16 0.122 0
HPF1 HPF1 Q9NWY4 Histone PARylation factor 1 chr4 GO:0006302 Not Cancer Driver No 32 0.092 23 0 0.0 0
HSF2BP HSF2BP O75031 Heat shock factor 2-binding protein chr21 GO:0006302 Not Cancer Driver No 52 0.156 23 3 0.13 1
INO80_ENST00000401393 INO80 Q9ULG1 Chromatin-remodeling ATPase INO80 chr15 GO:0006302 Compendium Yes 173 0.111 682 76 0.111 0
KAT5_ENST00000377046 KAT5 Q92993 Histone acetyltransferase KAT5 chr11 GO:0006302 Not Cancer Driver No 65 0.127 173 21 0.121 3
LIG3 LIG3 P49916 DNA ligase 3 chr17 GO:0006302 Not Cancer Driver No 125 0.124 280 36 0.129 0
LIG4 LIG4 P49917 DNA ligase 4 chr13 GO:0006302 Not Cancer Driver No 134 0.147 63 10 0.159 2
MAD2L2 MAD2L2 Q9UI95 Mitotic spindle assembly checkpoint protein MAD2B chr1 GO:0006302 Not Cancer Driver No 22 0.104 0 0 0.0 1
MARF1 MARF1 Q9Y4F3 Meiosis regulator and mRNA stability factor 1 chr16 GO:0006302 Not Cancer Driver No 199 0.114 524 73 0.139 0
MEIOC MEIOC A2RUB1 Meiosis-specific coiled-coil domain-containing protein MEIOC chr17 GO:0006302 Not Cancer Driver No 92 0.097 529 54 0.102 0
MRE11 MRE11 P49959 Double-strand break repair protein MRE11 chr11 GO:0006302 Not Cancer Driver No 84 0.119 292 35 0.12 1
MSH2 MSH2 P43246 DNA mismatch repair protein Msh2 chr2 GO:0006302 Census Yes 92 0.099 37 4 0.108 70
MTA1 MTA1 Q13330 Metastasis-associated protein MTA1 chr14 GO:0006302 Not Cancer Driver No 92 0.129 327 42 0.128 0
MUS81 MUS81 Q96NY9 Crossover junction endonuclease MUS81 chr11 GO:0006302 Not Cancer Driver No 67 0.122 232 38 0.164 0
NBN NBN O60934 Nibrin chr8 GO:0006302 Census Yes 90 0.119 417 54 0.129 1
NIPBL NIPBL Q6KC79 Nipped-B-like protein chr5 GO:0006302 Compendium Yes 353 0.126 1528 184 0.12 37
NSD2_ENST00000382892 NSD2 O96028 Histone-lysine N-methyltransferase NSD2 chr4 GO:0006302 Census, Compendium Yes 191 0.14 552 76 0.138 0
PARP1 PARP1 P09874 Poly [ADP-ribose] polymerase 1 chr1 GO:0006302 Not Cancer Driver No 119 0.117 320 34 0.106 0
PARP2 PARP2 Q9UGN5 Poly [ADP-ribose] polymerase 2 chr14 GO:0006302 Not Cancer Driver No 74 0.127 172 23 0.134 0
PARP3_ENST00000431474 PARP3 Q9Y6F1 Protein mono-ADP-ribosyltransferase PARP3 chr3 GO:0006302 Not Cancer Driver No 70 0.131 269 38 0.141 0
PARP9 PARP9 Q8IXQ6 Protein mono-ADP-ribosyltransferase PARP9 chr3 GO:0006302 Not Cancer Driver No 110 0.129 45 3 0.067 0
PIAS4 PIAS4 Q8N2W9 E3 SUMO-protein ligase PIAS4 chr19 GO:0006302 Not Cancer Driver No 58 0.114 142 23 0.162 0
POLN_ENST00000382865 POLN Q7Z5Q5 DNA polymerase nu chr4 GO:0006302 Not Cancer Driver No 115 0.128 247 28 0.113 0
POLQ POLQ O75417 DNA polymerase theta chr3 GO:0006302 Census, Compendium Yes 364 0.141 949 135 0.142 0
PPP5C PPP5C P53041 Serine/threonine-protein phosphatase 5 chr19 GO:0006302 Not Cancer Driver No 70 0.14 73 12 0.164 0
PRDM9 PRDM9 Q9NQV7 Histone-lysine N-methyltransferase PRDM9 chr5 GO:0006302 Not Cancer Driver No 494 0.553 372 201 0.54 0
PRKDC PRKDC P78527 DNA-dependent protein kinase catalytic subunit chr8 GO:0006302 Not Cancer Driver No 538 0.13 421 61 0.145 2
RAD21 RAD21 O60216 Double-strand-break repair protein rad21 homolog chr8 GO:0006302 Census, Compendium Yes 115 0.182 421 74 0.176 3
RAD21L1 RAD21L1 Q9H4I0 Double-strand-break repair protein rad21-like protein 1 chr20 GO:0006302 Not Cancer Driver No 37 0.067 186 5 0.027 0
RAD50 RAD50 Q92878 DNA repair protein RAD50 chr5 GO:0006302 Not Cancer Driver No 157 0.12 730 84 0.115 0
RAD51_ENST00000267868 RAD51 Q06609 DNA repair protein RAD51 homolog 1 chr15 GO:0006302 Not Cancer Driver No 42 0.124 47 5 0.106 3
RAD52 RAD52 P43351 DNA repair protein RAD52 homolog chr12 GO:0006302 Not Cancer Driver No 41 0.098 251 30 0.12 0
RAD54L_ENST00000442598 RAD54L Q92698 DNA repair and recombination protein RAD54-like chr1 GO:0006302 Not Cancer Driver No 79 0.106 124 13 0.105 0
REC8_ENST00000611366 REC8 O95072 Meiotic recombination protein REC8 homolog chr14 GO:0006302 Not Cancer Driver No 60 0.11 244 26 0.107 0
RECQL5 RECQL5 O94762 ATP-dependent DNA helicase Q5 chr17 GO:0006302 Not Cancer Driver No 132 0.133 495 71 0.143 0
RNF168 RNF168 Q8IYW5 E3 ubiquitin-protein ligase RNF168 chr3 GO:0006302 Not Cancer Driver No 77 0.135 471 66 0.14 0
RNF169 RNF169 Q8NCN4 E3 ubiquitin-protein ligase RNF169 chr11 GO:0006302 Not Cancer Driver No 52 0.073 637 46 0.072 0
RNF8 RNF8 O76064 E3 ubiquitin-protein ligase RNF8 chr6 GO:0006302 Not Cancer Driver No 56 0.115 226 29 0.128 0
SETX SETX Q7Z333 Probable helicase senataxin chr9 GO:0006302 Not Cancer Driver No 342 0.128 1240 156 0.126 20
SMCHD1 SMCHD1 A6NHR9 Structural maintenance of chromosomes flexible hinge domain-containing protein 1 chr18 GO:0006302 Not Cancer Driver No 240 0.12 342 45 0.132 45
SPO11 SPO11 Q9Y5K1 Meiotic recombination protein SPO11 chr20 GO:0006302 Not Cancer Driver No 59 0.149 26 5 0.192 0
TDP1_ENST00000393454 TDP1 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 chr14 GO:0006302 Not Cancer Driver No 81 0.133 179 25 0.14 1
TDP2 TDP2 O95551 Tyrosyl-DNA phosphodiesterase 2 chr6 GO:0006302 Not Cancer Driver No 55 0.152 80 10 0.125 0
TENT4A_ENST00000230859 TENT4A Q5XG87 Terminal nucleotidyltransferase 4A chr5 GO:0006302 Not Cancer Driver No 106 0.137 442 43 0.097 0
TNKS1BP1 TNKS1BP1 Q9C0C2 182 kDa tankyrase-1-binding protein chr11 GO:0006302 Not Cancer Driver No 221 0.128 1712 219 0.128 0
TP53_ENST00000445888 TP53 P04637 Cellular tumor antigen p53 chr17 GO:0006302 Census, Compendium Yes 2891 7.356 282 1466 5.199 83
TRIP13 TRIP13 Q15645 Pachytene checkpoint protein 2 homolog chr5 GO:0006302 Not Cancer Driver No 62 0.144 30 6 0.2 1
UIMC1_ENST00000511320 UIMC1 Q96RL1 BRCA1-A complex subunit RAP80 chr5 GO:0006302 Not Cancer Driver No 64 0.089 609 51 0.084 0
UVRAG UVRAG Q9P2Y5 UV radiation resistance-associated gene protein chr11 GO:0006302 Not Cancer Driver No 89 0.127 243 28 0.115 0
VCP VCP P55072 Transitional endoplasmic reticulum ATPase chr9 GO:0006302 Not Cancer Driver No 88 0.109 186 16 0.086 16
WRN WRN Q14191 Werner syndrome ATP-dependent helicase chr8 GO:0006302 Census, Compendium Yes 164 0.115 373 41 0.11 2
XRCC1 XRCC1 P18887 DNA repair protein XRCC1 chr19 GO:0006302 Not Cancer Driver No 85 0.134 426 53 0.124 1
XRCC3_ENST00000352127 XRCC3 O43542 DNA repair protein XRCC3 chr14 GO:0006302 Not Cancer Driver No 24 0.069 35 2 0.057 1
XRCC4 XRCC4 Q13426 DNA repair protein XRCC4 chr5 GO:0006302 Not Cancer Driver No 47 0.14 171 31 0.181 3
XRCC5_ENST00000392132 XRCC5 P13010 X-ray repair cross-complementing protein 5 chr2 GO:0006302 Not Cancer Driver No 87 0.119 118 11 0.093 0
XRCC6 XRCC6 P12956 X-ray repair cross-complementing protein 6 chr22 GO:0006302 Not Cancer Driver No 66 0.108 140 12 0.086 0
ZBTB7A_ENST00000601588 ZBTB7A O95365 Zinc finger and BTB domain-containing protein 7A chr19 GO:0006302 Not Cancer Driver No 60 0.103 285 30 0.105 0