Total number of protein in "GO:0006275" GO term: 92
| Identifier | UniProt Gene | UniProt Accession | UniProt Name | Chromosome | GO term | Database | Cancer Driver | Number of missense mutations | Missense mutation per residues | Number of disordered residues | Number of mutations in disordered regions | Disordered missense mutations per residues | Number of OMIM mutation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ACTL6A | ACTL6A | O96019 | Actin-like protein 6A | chr3 | GO:0006275 | Not Cancer Driver | No | 61 | 0.142 | 74 | 15 | 0.203 | 0 |
| ACTR5 | ACTR5 | Q9H9F9 | Actin-related protein 5 | chr20 | GO:0006275 | Not Cancer Driver | No | 63 | 0.104 | 163 | 23 | 0.141 | 0 |
| ACTR8 | ACTR8 | Q9H981 | Actin-related protein 8 | chr3 | GO:0006275 | Not Cancer Driver | No | 61 | 0.098 | 239 | 21 | 0.088 | 0 |
| ACVRL1 | ACVRL1 | P37023 | Serine/threonine-protein kinase receptor R3 | chr12 | GO:0006275 | Not Cancer Driver | No | 93 | 0.185 | 60 | 11 | 0.183 | 82 |
| AICDA | AICDA | Q9GZX7 | Single-stranded DNA cytosine deaminase | chr12 | GO:0006275 | Not Cancer Driver | No | 56 | 0.283 | 0 | 0 | 0.0 | 8 |
| ANKRD17 | ANKRD17 | O75179 | Ankyrin repeat domain-containing protein 17 | chr4 | GO:0006275 | Not Cancer Driver | No | 312 | 0.12 | 1790 | 221 | 0.123 | 9 |
| ATRX | ATRX | P46100 | Transcriptional regulator ATRX | chrX | GO:0006275 | Census, Compendium | Yes | 487 | 0.195 | 1672 | 301 | 0.18 | 33 |
| BAZ1A_ENST00000382422 | BAZ1A | Q9NRL2 | Bromodomain adjacent to zinc finger domain protein 1A | chr14 | GO:0006275 | Census | Yes | 156 | 0.1 | 752 | 65 | 0.086 | 0 |
| BCL6_ENST00000232014 | BCL6 | P41182 | B-cell lymphoma 6 protein | chr3 | GO:0006275 | Census, Compendium | Yes | 134 | 0.19 | 328 | 67 | 0.204 | 0 |
| BLM | BLM | P54132 | Bloom syndrome protein | chr15 | GO:0006275 | Census | Yes | 153 | 0.108 | 667 | 70 | 0.105 | 8 |
| BRCA2_ENST00000544455 | BRCA2 | P51587 | Breast cancer type 2 susceptibility protein | chr13 | GO:0006275 | Census, Compendium | Yes | 457 | 0.134 | 1542 | 225 | 0.146 | 46 |
| CCDC88A_ENST00000642200 | CCDC88A | Q3V6T2 | Girdin | chr2 | GO:0006275 | Not Cancer Driver | No | 226 | 0.121 | 1481 | 173 | 0.117 | 0 |
| CCNA2_ENST00000618014 | CCNA2 | P20248 | Cyclin-A2 | chr4 | GO:0006275 | Not Cancer Driver | No | 45 | 0.104 | 186 | 19 | 0.102 | 0 |
| CDC7 | CDC7 | O00311 | Cell division cycle 7-related protein kinase | chr1 | GO:0006275 | Not Cancer Driver | No | 72 | 0.125 | 185 | 24 | 0.13 | 0 |
| CDK2 | CDK2 | P24941 | Cyclin-dependent kinase 2 | chr12 | GO:0006275 | Not Cancer Driver | No | 24 | 0.081 | 0 | 0 | 0.0 | 0 |
| CDT1 | CDT1 | Q9H211 | DNA replication factor Cdt1 | chr16 | GO:0006275 | Not Cancer Driver | No | 60 | 0.11 | 377 | 35 | 0.093 | 5 |
| CHRAC1 | CHRAC1 | Q9NRG0 | Chromatin accessibility complex protein 1 | chr8 | GO:0006275 | Not Cancer Driver | No | 10 | 0.076 | 35 | 8 | 0.229 | 0 |
| CHTF18 | CHTF18 | Q8WVB6 | Chromosome transmission fidelity protein 18 homolog | chr16 | GO:0006275 | Not Cancer Driver | No | 114 | 0.117 | 503 | 56 | 0.111 | 0 |
| CHTF8_ENST00000398235 | CHTF8 | P0CG13 | Chromosome transmission fidelity protein 8 homolog | chr16 | GO:0006275 | Not Cancer Driver | No | 13 | 0.107 | 7 | 0 | 0.0 | 0 |
| CIZ1_ENST00000634901 | CIZ1 | Q9ULV3 | Cip1-interacting zinc finger protein | chr9 | GO:0006275 | Not Cancer Driver | No | 93 | 0.104 | 708 | 83 | 0.117 | 0 |
| DACH1_ENST00000619232 | DACH1 | Q9UI36 | Dachshund homolog 1 | chr13 | GO:0006275 | Not Cancer Driver | No | 157 | 0.207 | 641 | 134 | 0.209 | 0 |
| DBF4 | DBF4 | Q9UBU7 | Protein DBF4 homolog A | chr7 | GO:0006275 | Not Cancer Driver | No | 75 | 0.111 | 333 | 26 | 0.078 | 0 |
| DBF4B | DBF4B | Q8NFT6 | Protein DBF4 homolog B | chr17 | GO:0006275 | Not Cancer Driver | No | 68 | 0.111 | 311 | 22 | 0.071 | 0 |
| DONSON | DONSON | Q9NYP3 | Protein downstream neighbor of Son | chr21 | GO:0006275 | Not Cancer Driver | No | 50 | 0.088 | 217 | 13 | 0.06 | 6 |
| DSCC1 | DSCC1 | Q9BVC3 | Sister chromatid cohesion protein DCC1 | chr8 | GO:0006275 | Not Cancer Driver | No | 28 | 0.071 | 41 | 4 | 0.098 | 0 |
| E2F7 | E2F7 | Q96AV8 | Transcription factor E2F7 | chr12 | GO:0006275 | Not Cancer Driver | No | 122 | 0.134 | 554 | 70 | 0.126 | 0 |
| E2F8_ENST00000250024 | E2F8 | A0AVK6 | Transcription factor E2F8 | chr11 | GO:0006275 | Not Cancer Driver | No | 132 | 0.152 | 582 | 85 | 0.146 | 0 |
| EHMT2_ENST00000375537 | EHMT2 | Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | chr6 | GO:0006275 | Not Cancer Driver | No | 142 | 0.117 | 585 | 71 | 0.121 | 0 |
| ENDOG | ENDOG | Q14249 | Endonuclease G, mitochondrial | chr9 | GO:0006275 | Not Cancer Driver | No | 11 | 0.037 | 61 | 1 | 0.016 | 0 |
| ESCO1 | ESCO1 | Q5FWF5 | N-acetyltransferase ESCO1 | chr18 | GO:0006275 | Not Cancer Driver | No | 92 | 0.11 | 594 | 66 | 0.111 | 0 |
| ESCO2 | ESCO2 | Q56NI9 | N-acetyltransferase ESCO2 | chr8 | GO:0006275 | Not Cancer Driver | No | 67 | 0.111 | 292 | 32 | 0.11 | 1 |
| FBH1_ENST00000362091 | FBH1 | Q8NFZ0 | F-box DNA helicase 1 | chr10 | GO:0006275 | Not Cancer Driver | No | 139 | 0.133 | 192 | 32 | 0.167 | 0 |
| FBXO5 | FBXO5 | Q9UKT4 | F-box only protein 5 | chr6 | GO:0006275 | Not Cancer Driver | No | 48 | 0.107 | 113 | 13 | 0.115 | 0 |
| GINS1 | GINS1 | Q14691 | DNA replication complex GINS protein PSF1 | chr20 | GO:0006275 | Not Cancer Driver | No | 21 | 0.107 | 18 | 3 | 0.167 | 2 |
| GINS2 | GINS2 | Q9Y248 | DNA replication complex GINS protein PSF2 | chr16 | GO:0006275 | Not Cancer Driver | No | 19 | 0.103 | 38 | 5 | 0.132 | 0 |
| GINS3_ENST00000318129 | GINS3 | Q9BRX5 | DNA replication complex GINS protein PSF3 | chr16 | GO:0006275 | Not Cancer Driver | No | 36 | 0.167 | 14 | 0 | 0.0 | 0 |
| GINS4 | GINS4 | Q9BRT9 | DNA replication complex GINS protein SLD5 | chr8 | GO:0006275 | Not Cancer Driver | No | 32 | 0.143 | 77 | 14 | 0.182 | 0 |
| GMNN_ENST00000620958 | GMNN | O75496 | Geminin | chr6 | GO:0006275 | Not Cancer Driver | No | 24 | 0.115 | 206 | 24 | 0.117 | 1 |
| ID3 | ID3 | Q02535 | DNA-binding protein inhibitor ID-3 | chr1 | GO:0006275 | Census, Compendium | Yes | 14 | 0.118 | 34 | 4 | 0.118 | 0 |
| ING5_ENST00000313552 | ING5 | Q8WYH8 | Inhibitor of growth protein 5 | chr2 | GO:0006275 | Not Cancer Driver | No | 25 | 0.104 | 119 | 9 | 0.076 | 0 |
| INO80B | INO80B | Q9C086 | INO80 complex subunit B | chr2 | GO:0006275 | Not Cancer Driver | No | 35 | 0.098 | 336 | 33 | 0.098 | 0 |
| INO80C_ENST00000334598 | INO80C | Q6PI98 | INO80 complex subunit C | chr18 | GO:0006275 | Not Cancer Driver | No | 18 | 0.094 | 109 | 11 | 0.101 | 0 |
| INO80D | INO80D | Q53TQ3 | INO80 complex subunit D | chr2 | GO:0006275 | Not Cancer Driver | No | 110 | 0.107 | 738 | 93 | 0.126 | 0 |
| INO80E | INO80E | Q8NBZ0 | INO80 complex subunit E | chr16 | GO:0006275 | Not Cancer Driver | No | 21 | 0.086 | 210 | 21 | 0.1 | 0 |
| INO80_ENST00000401393 | INO80 | Q9ULG1 | Chromatin-remodeling ATPase INO80 | chr15 | GO:0006275 | Compendium | Yes | 173 | 0.111 | 682 | 76 | 0.111 | 0 |
| JADE1_ENST00000512960 | JADE1 | Q6IE81 | Protein Jade-1 | chr4 | GO:0006275 | Not Cancer Driver | No | 94 | 0.112 | 409 | 47 | 0.115 | 0 |
| JADE2_ENST00000395003 | JADE2 | Q9NQC1 | E3 ubiquitin-protein ligase Jade-2 | chr5 | GO:0006275 | Not Cancer Driver | No | 91 | 0.115 | 427 | 50 | 0.117 | 0 |
| JADE3_ENST00000611250 | JADE3 | Q92613 | Protein Jade-3 | chrX | GO:0006275 | Not Cancer Driver | No | 110 | 0.134 | 421 | 52 | 0.124 | 0 |
| KAT7 | KAT7 | O95251 | Histone acetyltransferase KAT7 | chr17 | GO:0006275 | Census | Yes | 97 | 0.159 | 327 | 47 | 0.144 | 0 |
| LIG3 | LIG3 | P49916 | DNA ligase 3 | chr17 | GO:0006275 | Not Cancer Driver | No | 125 | 0.124 | 280 | 36 | 0.129 | 0 |
| MCIDAS | MCIDAS | D6RGH6 | Multicilin | chr5 | GO:0006275 | Not Cancer Driver | No | 4 | 0.01 | 269 | 4 | 0.015 | 2 |
| MCRS1_ENST00000550165 | MCRS1 | Q96EZ8 | Microspherule protein 1 | chr12 | GO:0006275 | Not Cancer Driver | No | 72 | 0.156 | 151 | 18 | 0.119 | 0 |
| MEAF6_ENST00000296214 | MEAF6 | Q9HAF1 | Chromatin modification-related protein MEAF6 | chr1 | GO:0006275 | Not Cancer Driver | No | 22 | 0.115 | 171 | 21 | 0.123 | 0 |
| METTL4 | METTL4 | Q8N3J2 | N(6)-adenine-specific methyltransferase METTL4 | chr18 | GO:0006275 | Not Cancer Driver | No | 61 | 0.129 | 34 | 4 | 0.118 | 0 |
| NBN | NBN | O60934 | Nibrin | chr8 | GO:0006275 | Census | Yes | 90 | 0.119 | 417 | 54 | 0.129 | 1 |
| NFRKB_ENST00000446488 | NFRKB | Q6P4R8 | Nuclear factor related to kappa-B-binding protein | chr11 | GO:0006275 | Not Cancer Driver | No | 128 | 0.099 | 838 | 74 | 0.088 | 0 |
| NUCKS1 | NUCKS1 | Q9H1E3 | Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 | chr1 | GO:0006275 | Not Cancer Driver | No | 30 | 0.123 | 243 | 30 | 0.123 | 0 |
| NUGGC | NUGGC | Q68CJ6 | Nuclear GTPase SLIP-GC | chr8 | GO:0006275 | Not Cancer Driver | No | 143 | 0.18 | 141 | 21 | 0.149 | 0 |
| ORC3_ENST00000392844 | ORC3 | Q9UBD5 | Origin recognition complex subunit 3 | chr6 | GO:0006275 | Not Cancer Driver | No | 70 | 0.098 | 63 | 5 | 0.079 | 0 |
| ORC5 | ORC5 | O43913 | Origin recognition complex subunit 5 | chr7 | GO:0006275 | Not Cancer Driver | No | 43 | 0.099 | 16 | 2 | 0.125 | 0 |
| PCNA | PCNA | P12004 | Proliferating cell nuclear antigen | chr20 | GO:0006275 | Not Cancer Driver | No | 30 | 0.115 | 22 | 3 | 0.136 | 1 |
| POLE3 | POLE3 | Q9NRF9 | DNA polymerase epsilon subunit 3 | chr9 | GO:0006275 | Not Cancer Driver | No | 11 | 0.075 | 117 | 9 | 0.077 | 0 |
| POLG2 | POLG2 | Q9UHN1 | DNA polymerase subunit gamma-2, mitochondrial | chr17 | GO:0006275 | Not Cancer Driver | No | 64 | 0.132 | 46 | 4 | 0.087 | 3 |
| PPP2CA | PPP2CA | P67775 | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | chr5 | GO:0006275 | Not Cancer Driver | No | 41 | 0.133 | 12 | 1 | 0.083 | 8 |
| PPP2R1A | PPP2R1A | P30153 | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform | chr19 | GO:0006275 | Census, Compendium | Yes | 179 | 0.304 | 0 | 0 | 0.0 | 4 |
| RBBP6 | RBBP6 | Q7Z6E9 | E3 ubiquitin-protein ligase RBBP6 | chr16 | GO:0006275 | Not Cancer Driver | No | 229 | 0.128 | 1626 | 212 | 0.13 | 0 |
| RFC2 | RFC2 | P35250 | Replication factor C subunit 2 | chr7 | GO:0006275 | Not Cancer Driver | No | 45 | 0.127 | 39 | 6 | 0.154 | 0 |
| RFC3 | RFC3 | P40938 | Replication factor C subunit 3 | chr13 | GO:0006275 | Not Cancer Driver | No | 31 | 0.087 | 13 | 1 | 0.077 | 0 |
| RFC4_ENST00000296273 | RFC4 | P35249 | Replication factor C subunit 4 | chr3 | GO:0006275 | Not Cancer Driver | No | 58 | 0.16 | 50 | 8 | 0.16 | 0 |
| RFC5 | RFC5 | P40937 | Replication factor C subunit 5 | chr12 | GO:0006275 | Not Cancer Driver | No | 38 | 0.112 | 20 | 1 | 0.05 | 0 |
| RNF219 | OBI1 | Q5W0B1 | ORC ubiquitin ligase 1 | chr13 | GO:0006275 | Not Cancer Driver | No | 96 | 0.132 | 486 | 67 | 0.138 | 0 |
| RUVBL1 | RUVBL1 | Q9Y265 | RuvB-like 1 | chr3 | GO:0006275 | Not Cancer Driver | No | 54 | 0.118 | 67 | 7 | 0.104 | 0 |
| RUVBL2 | RUVBL2 | Q9Y230 | RuvB-like 2 | chr19 | GO:0006275 | Not Cancer Driver | No | 62 | 0.134 | 100 | 13 | 0.13 | 0 |
| SENP2 | SENP2 | Q9HC62 | Sentrin-specific protease 2 | chr3 | GO:0006275 | Not Cancer Driver | No | 73 | 0.124 | 285 | 38 | 0.133 | 0 |
| SLFN11_ENST00000308377 | SLFN11 | Q7Z7L1 | Schlafen family member 11 | chr17 | GO:0006275 | Not Cancer Driver | No | 177 | 0.196 | 34 | 8 | 0.235 | 0 |
| SMARCA5 | SMARCA5 | O60264 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 | chr4 | GO:0006275 | Not Cancer Driver | No | 116 | 0.11 | 363 | 48 | 0.132 | 0 |
| SMARCAL1 | SMARCAL1 | Q9NZC9 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 | chr2 | GO:0006275 | Not Cancer Driver | No | 128 | 0.134 | 335 | 49 | 0.146 | 11 |
| SMC3 | SMC3 | Q9UQE7 | Structural maintenance of chromosomes protein 3 | chr10 | GO:0006275 | Not Cancer Driver | No | 149 | 0.122 | 605 | 70 | 0.116 | 0 |
| SSBP1_ENST00000484178 | SSBP1 | Q04837 | Single-stranded DNA-binding protein, mitochondrial | chr7 | GO:0006275 | Not Cancer Driver | No | 27 | 0.182 | 0 | 0 | 0.0 | 6 |
| STOML2 | STOML2 | Q9UJZ1 | Stomatin-like protein 2, mitochondrial | chr9 | GO:0006275 | Not Cancer Driver | No | 40 | 0.112 | 117 | 9 | 0.077 | 0 |
| TFPT | TFPT | P0C1Z6 | TCF3 fusion partner | chr19 | GO:0006275 | Census | Yes | 41 | 0.162 | 237 | 41 | 0.173 | 0 |
| TICRR | TICRR | Q7Z2Z1 | Treslin | chr15 | GO:0006275 | Not Cancer Driver | No | 201 | 0.105 | 1308 | 129 | 0.099 | 0 |
| TIMELESS | TIMELESS | Q9UNS1 | Protein timeless homolog | chr12 | GO:0006275 | Not Cancer Driver | No | 154 | 0.127 | 367 | 51 | 0.139 | 0 |
| TIPIN | TIPIN | Q9BVW5 | TIMELESS-interacting protein | chr15 | GO:0006275 | Not Cancer Driver | No | 26 | 0.086 | 242 | 19 | 0.079 | 0 |
| UCHL5 | UCHL5 | Q9Y5K5 | Ubiquitin carboxyl-terminal hydrolase isozyme L5 | chr1 | GO:0006275 | Not Cancer Driver | No | 33 | 0.1 | 41 | 7 | 0.171 | 0 |
| USP37_ENST00000454775 | USP37 | Q86T82 | Ubiquitin carboxyl-terminal hydrolase 37 | chr2 | GO:0006275 | Not Cancer Driver | No | 112 | 0.114 | 530 | 62 | 0.117 | 0 |
| WRNIP1 | WRNIP1 | Q96S55 | ATPase WRNIP1 | chr6 | GO:0006275 | Not Cancer Driver | No | 50 | 0.075 | 292 | 7 | 0.024 | 0 |
| YY1 | YY1 | P25490 | Transcriptional repressor protein YY1 | chr14 | GO:0006275 | Not Cancer Driver | No | 37 | 0.089 | 336 | 26 | 0.077 | 2 |
| ZBTB38_ENST00000441582 | ZBTB38 | Q8NAP3 | Zinc finger and BTB domain-containing protein 38 | chr3 | GO:0006275 | Not Cancer Driver | No | 137 | 0.115 | 648 | 73 | 0.113 | 0 |
| ZMPSTE24 | ZMPSTE24 | O75844 | CAAX prenyl protease 1 homolog | chr1 | GO:0006275 | Not Cancer Driver | No | 67 | 0.141 | 23 | 0 | 0.0 | 3 |
| ZNF830 | ZNF830 | Q96NB3 | Zinc finger protein 830 | chr17 | GO:0006275 | Not Cancer Driver | No | 39 | 0.105 | 312 | 37 | 0.119 | 0 |
| ZRANB3 | ZRANB3 | Q5FWF4 | DNA annealing helicase and endonuclease ZRANB3 | chr2 | GO:0006275 | Not Cancer Driver | No | 126 | 0.117 | 261 | 31 | 0.119 | 0 |