Total number of protein in "GO:0006260" GO term: 106
| Identifier | UniProt Gene | UniProt Accession | UniProt Name | Chromosome | GO term | Database | Cancer Driver | Number of missense mutations | Missense mutation per residues | Number of disordered residues | Number of mutations in disordered regions | Disordered missense mutations per residues | Number of OMIM mutation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ADRA2A | ADRA2A | P08913 | Alpha-2A adrenergic receptor | chr10 | GO:0006260 | Not Cancer Driver | No | 67 | 0.144 | 161 | 10 | 0.062 | 0 |
| ATR | ATR | Q13535 | Serine/threonine-protein kinase ATR | chr3 | GO:0006260 | Census, Compendium | Yes | 338 | 0.128 | 106 | 14 | 0.132 | 1 |
| BLM | BLM | P54132 | Bloom syndrome protein | chr15 | GO:0006260 | Census | Yes | 153 | 0.108 | 667 | 70 | 0.105 | 8 |
| CCDC88A_ENST00000642200 | CCDC88A | Q3V6T2 | Girdin | chr2 | GO:0006260 | Not Cancer Driver | No | 226 | 0.121 | 1481 | 173 | 0.117 | 0 |
| CDK1 | CDK1 | P06493 | Cyclin-dependent kinase 1 | chr10 | GO:0006260 | Not Cancer Driver | No | 40 | 0.135 | 1 | 0 | 0.0 | 0 |
| CDK2 | CDK2 | P24941 | Cyclin-dependent kinase 2 | chr12 | GO:0006260 | Not Cancer Driver | No | 24 | 0.081 | 0 | 0 | 0.0 | 0 |
| CHAF1A | CHAF1A | Q13111 | Chromatin assembly factor 1 subunit A | chr19 | GO:0006260 | Not Cancer Driver | No | 133 | 0.139 | 767 | 99 | 0.129 | 0 |
| CHAF1B | CHAF1B | Q13112 | Chromatin assembly factor 1 subunit B | chr21 | GO:0006260 | Not Cancer Driver | No | 65 | 0.116 | 186 | 30 | 0.161 | 0 |
| CHEK1_ENST00000428830 | CHEK1 | O14757 | Serine/threonine-protein kinase Chk1 | chr11 | GO:0006260 | Not Cancer Driver | No | 58 | 0.122 | 86 | 16 | 0.186 | 0 |
| CHTF18 | CHTF18 | Q8WVB6 | Chromosome transmission fidelity protein 18 homolog | chr16 | GO:0006260 | Not Cancer Driver | No | 114 | 0.117 | 503 | 56 | 0.111 | 0 |
| CHTF8_ENST00000398235 | CHTF8 | P0CG13 | Chromosome transmission fidelity protein 8 homolog | chr16 | GO:0006260 | Not Cancer Driver | No | 13 | 0.107 | 7 | 0 | 0.0 | 0 |
| CINP | CINP | Q9BW66 | Cyclin-dependent kinase 2-interacting protein | chr14 | GO:0006260 | Not Cancer Driver | No | 22 | 0.104 | 41 | 5 | 0.122 | 0 |
| DBF4 | DBF4 | Q9UBU7 | Protein DBF4 homolog A | chr7 | GO:0006260 | Not Cancer Driver | No | 75 | 0.111 | 333 | 26 | 0.078 | 0 |
| DHX9 | DHX9 | Q08211 | ATP-dependent RNA helicase A | chr1 | GO:0006260 | Compendium | Yes | 182 | 0.143 | 331 | 42 | 0.127 | 0 |
| DNA2 | DNA2 | P51530 | DNA replication ATP-dependent helicase/nuclease DNA2 | chr10 | GO:0006260 | Not Cancer Driver | No | 120 | 0.113 | 52 | 8 | 0.154 | 3 |
| DNAJA3 | DNAJA3 | Q96EY1 | DnaJ homolog subfamily A member 3, mitochondrial | chr16 | GO:0006260 | Not Cancer Driver | No | 50 | 0.104 | 152 | 21 | 0.138 | 0 |
| DNAJC2 | DNAJC2 | Q99543 | DnaJ homolog subfamily C member 2 | chr7 | GO:0006260 | Not Cancer Driver | No | 67 | 0.108 | 425 | 48 | 0.113 | 0 |
| DONSON | DONSON | Q9NYP3 | Protein downstream neighbor of Son | chr21 | GO:0006260 | Not Cancer Driver | No | 50 | 0.088 | 217 | 13 | 0.06 | 6 |
| DSCC1 | DSCC1 | Q9BVC3 | Sister chromatid cohesion protein DCC1 | chr8 | GO:0006260 | Not Cancer Driver | No | 28 | 0.071 | 41 | 4 | 0.098 | 0 |
| DTD1 | DTD1 | Q8TEA8 | D-aminoacyl-tRNA deacylase 1 | chr20 | GO:0006260 | Not Cancer Driver | No | 45 | 0.215 | 93 | 26 | 0.28 | 0 |
| DTL | DTL | Q9NZJ0 | Denticleless protein homolog | chr1 | GO:0006260 | Not Cancer Driver | No | 73 | 0.1 | 331 | 49 | 0.148 | 0 |
| DUT | DUT | P33316 | Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial | chr15 | GO:0006260 | Not Cancer Driver | No | 19 | 0.075 | 128 | 8 | 0.062 | 0 |
| E4F1 | E4F1 | Q66K89 | Transcription factor E4F1 | chr16 | GO:0006260 | Not Cancer Driver | No | 84 | 0.107 | 462 | 46 | 0.1 | 0 |
| FAM111A | FAM111A | Q96PZ2 | Serine protease FAM111A | chr11 | GO:0006260 | Not Cancer Driver | No | 78 | 0.128 | 169 | 23 | 0.136 | 5 |
| FAM111B_ENST00000620384 | FAM111B | Q6SJ93 | Serine protease FAM111B | chr11 | GO:0006260 | Not Cancer Driver | No | 92 | 0.125 | 190 | 18 | 0.095 | 3 |
| FEN1 | FEN1 | P39748 | Flap endonuclease 1 | chr11 | GO:0006260 | Census | Yes | 35 | 0.092 | 111 | 11 | 0.099 | 0 |
| GRWD1 | GRWD1 | Q9BQ67 | Glutamate-rich WD repeat-containing protein 1 | chr19 | GO:0006260 | Not Cancer Driver | No | 44 | 0.099 | 187 | 14 | 0.075 | 0 |
| HELB | HELB | Q8NG08 | DNA helicase B | chr12 | GO:0006260 | Not Cancer Driver | No | 140 | 0.129 | 300 | 38 | 0.127 | 0 |
| IGHMBP2 | IGHMBP2 | P38935 | DNA-binding protein SMUBP-2 | chr11 | GO:0006260 | Not Cancer Driver | No | 136 | 0.137 | 354 | 53 | 0.15 | 31 |
| ING4 | ING4 | Q9UNL4 | Inhibitor of growth protein 4 | chr12 | GO:0006260 | Not Cancer Driver | No | 31 | 0.124 | 108 | 15 | 0.139 | 0 |
| ING5_ENST00000313552 | ING5 | Q8WYH8 | Inhibitor of growth protein 5 | chr2 | GO:0006260 | Not Cancer Driver | No | 25 | 0.104 | 119 | 9 | 0.076 | 0 |
| KAT7 | KAT7 | O95251 | Histone acetyltransferase KAT7 | chr17 | GO:0006260 | Census | Yes | 97 | 0.159 | 327 | 47 | 0.144 | 0 |
| KIN | KIN | O60870 | DNA/RNA-binding protein KIN17 | chr10 | GO:0006260 | Not Cancer Driver | No | 52 | 0.132 | 137 | 13 | 0.095 | 0 |
| LIG4 | LIG4 | P49917 | DNA ligase 4 | chr13 | GO:0006260 | Not Cancer Driver | No | 134 | 0.147 | 63 | 10 | 0.159 | 2 |
| MCM2 | MCM2 | P49736 | DNA replication licensing factor MCM2 | chr3 | GO:0006260 | Not Cancer Driver | No | 104 | 0.115 | 275 | 38 | 0.138 | 1 |
| MCM4 | MCM4 | P33991 | DNA replication licensing factor MCM4 | chr8 | GO:0006260 | Not Cancer Driver | No | 121 | 0.14 | 215 | 35 | 0.163 | 0 |
| MCM5 | MCM5 | P33992 | DNA replication licensing factor MCM5 | chr22 | GO:0006260 | Not Cancer Driver | No | 88 | 0.12 | 109 | 20 | 0.183 | 1 |
| MCM6 | MCM6 | Q14566 | DNA replication licensing factor MCM6 | chr2 | GO:0006260 | Not Cancer Driver | No | 101 | 0.123 | 122 | 13 | 0.107 | 0 |
| MCM7 | MCM7 | P33993 | DNA replication licensing factor MCM7 | chr7 | GO:0006260 | Not Cancer Driver | No | 101 | 0.14 | 128 | 22 | 0.172 | 0 |
| MCM8_ENST00000378896 | MCM8 | Q9UJA3 | DNA helicase MCM8 | chr20 | GO:0006260 | Not Cancer Driver | No | 94 | 0.112 | 188 | 19 | 0.101 | 1 |
| MCM9_ENST00000619706 | MCM9 | Q9NXL9 | DNA helicase MCM9 | chr6 | GO:0006260 | Not Cancer Driver | No | 56 | 0.049 | 523 | 13 | 0.025 | 0 |
| MGME1 | MGME1 | Q9BQP7 | Mitochondrial genome maintenance exonuclease 1 | chr20 | GO:0006260 | Not Cancer Driver | No | 33 | 0.096 | 95 | 7 | 0.074 | 1 |
| NAP1L1 | NAP1L1 | P55209 | Nucleosome assembly protein 1-like 1 | chr12 | GO:0006260 | Not Cancer Driver | No | 47 | 0.12 | 207 | 31 | 0.15 | 0 |
| NASP | NASP | P49321 | Nuclear autoantigenic sperm protein | chr1 | GO:0006260 | Not Cancer Driver | No | 95 | 0.121 | 615 | 81 | 0.132 | 0 |
| NFIA_ENST00000403491 | NFIA | Q12857 | Nuclear factor 1 A-type | chr1 | GO:0006260 | Not Cancer Driver | No | 78 | 0.153 | 347 | 55 | 0.159 | 0 |
| NFIB_ENST00000380959 | NFIB | O00712 | Nuclear factor 1 B-type | chr9 | GO:0006260 | Census | Yes | 63 | 0.15 | 254 | 36 | 0.142 | 3 |
| NFIC | NFIC | P08651 | Nuclear factor 1 C-type | chr19 | GO:0006260 | Not Cancer Driver | No | 61 | 0.12 | 327 | 44 | 0.135 | 0 |
| NFIX_ENST00000592199 | NFIX | Q14938 | Nuclear factor 1 X-type | chr19 | GO:0006260 | Not Cancer Driver | No | 60 | 0.12 | 305 | 40 | 0.131 | 6 |
| NT5M | NT5M | Q9NPB1 | 5'(3')-deoxyribonucleotidase, mitochondrial | chr17 | GO:0006260 | Not Cancer Driver | No | 20 | 0.088 | 0 | 0 | 0.0 | 0 |
| ORC3_ENST00000392844 | ORC3 | Q9UBD5 | Origin recognition complex subunit 3 | chr6 | GO:0006260 | Not Cancer Driver | No | 70 | 0.098 | 63 | 5 | 0.079 | 0 |
| ORC5 | ORC5 | O43913 | Origin recognition complex subunit 5 | chr7 | GO:0006260 | Not Cancer Driver | No | 43 | 0.099 | 16 | 2 | 0.125 | 0 |
| PCLAF | PCLAF | Q15004 | PCNA-associated factor | chr15 | GO:0006260 | Not Cancer Driver | No | 20 | 0.18 | 111 | 20 | 0.18 | 0 |
| PIF1_ENST00000559239 | PIF1 | Q9H611 | ATP-dependent DNA helicase PIF1 | chr15 | GO:0006260 | Not Cancer Driver | No | 54 | 0.084 | 209 | 11 | 0.053 | 0 |
| POLA1_ENST00000379059 | POLA1 | P09884 | DNA polymerase alpha catalytic subunit | chrX | GO:0006260 | Not Cancer Driver | No | 185 | 0.127 | 347 | 45 | 0.13 | 3 |
| POLA2 | POLA2 | Q14181 | DNA polymerase alpha subunit B | chr11 | GO:0006260 | Not Cancer Driver | No | 63 | 0.105 | 102 | 16 | 0.157 | 0 |
| POLD1_ENST00000440232 | POLD1 | P28340 | DNA polymerase delta catalytic subunit | chr19 | GO:0006260 | Census, Compendium | Yes | 179 | 0.162 | 214 | 31 | 0.145 | 2 |
| POLD2_ENST00000452185 | POLD2 | P49005 | DNA polymerase delta subunit 2 | chr7 | GO:0006260 | Not Cancer Driver | No | 49 | 0.104 | 65 | 3 | 0.046 | 0 |
| POLE | POLE | Q07864 | DNA polymerase epsilon catalytic subunit A | chr12 | GO:0006260 | Census, Compendium | Yes | 409 | 0.179 | 239 | 44 | 0.184 | 3 |
| POLE2 | POLE2 | P56282 | DNA polymerase epsilon subunit 2 | chr14 | GO:0006260 | Not Cancer Driver | No | 53 | 0.101 | 32 | 2 | 0.062 | 0 |
| POLE3 | POLE3 | Q9NRF9 | DNA polymerase epsilon subunit 3 | chr9 | GO:0006260 | Not Cancer Driver | No | 11 | 0.075 | 117 | 9 | 0.077 | 0 |
| POLG2 | POLG2 | Q9UHN1 | DNA polymerase subunit gamma-2, mitochondrial | chr17 | GO:0006260 | Not Cancer Driver | No | 64 | 0.132 | 46 | 4 | 0.087 | 3 |
| POLG_ENST00000442287 | POLG | P54098 | DNA polymerase subunit gamma-1 | chr15 | GO:0006260 | Census | Yes | 139 | 0.112 | 421 | 42 | 0.1 | 73 |
| POLH | POLH | Q9Y253 | DNA polymerase eta | chr6 | GO:0006260 | Not Cancer Driver | No | 72 | 0.101 | 291 | 20 | 0.069 | 10 |
| POLI | POLI | Q9UNA4 | DNA polymerase iota | chr18 | GO:0006260 | Not Cancer Driver | No | 82 | 0.111 | 300 | 32 | 0.107 | 0 |
| POLK | POLK | Q9UBT6 | DNA polymerase kappa | chr5 | GO:0006260 | Not Cancer Driver | No | 97 | 0.111 | 293 | 36 | 0.123 | 0 |
| POLL_ENST00000370169 | POLL | Q9UGP5 | DNA polymerase lambda | chr10 | GO:0006260 | Not Cancer Driver | No | 69 | 0.12 | 215 | 16 | 0.074 | 0 |
| PRIMPOL_ENST00000503752 | PRIMPOL | Q96LW4 | DNA-directed primase/polymerase protein | chr4 | GO:0006260 | Not Cancer Driver | No | 50 | 0.089 | 92 | 7 | 0.076 | 0 |
| PTMS_ENST00000309083 | PTMS | P20962 | Parathymosin | chr12 | GO:0006260 | Not Cancer Driver | No | 10 | 0.098 | 102 | 10 | 0.098 | 0 |
| RBBP4 | RBBP4 | Q09028 | Histone-binding protein RBBP4 | chr1 | GO:0006260 | Not Cancer Driver | No | 53 | 0.125 | 169 | 23 | 0.136 | 0 |
| RBBP6 | RBBP6 | Q7Z6E9 | E3 ubiquitin-protein ligase RBBP6 | chr16 | GO:0006260 | Not Cancer Driver | No | 229 | 0.128 | 1626 | 212 | 0.13 | 0 |
| RBBP7_ENST00000380087 | RBBP7 | Q16576 | Histone-binding protein RBBP7 | chrX | GO:0006260 | Not Cancer Driver | No | 67 | 0.158 | 138 | 19 | 0.138 | 0 |
| RBMS1 | RBMS1 | P29558 | RNA-binding motif, single-stranded-interacting protein 1 | chr2 | GO:0006260 | Not Cancer Driver | No | 55 | 0.135 | 243 | 36 | 0.148 | 0 |
| RECQL4 | RECQL4 | O94761 | ATP-dependent DNA helicase Q4 | chr8 | GO:0006260 | Census, Compendium | Yes | 138 | 0.114 | 608 | 71 | 0.117 | 1 |
| RECQL5 | RECQL5 | O94762 | ATP-dependent DNA helicase Q5 | chr17 | GO:0006260 | Not Cancer Driver | No | 132 | 0.133 | 495 | 71 | 0.143 | 0 |
| REPIN1_ENST00000397281 | REPIN1 | Q9BWE0 | Replication initiator 1 | chr7 | GO:0006260 | Not Cancer Driver | No | 62 | 0.109 | 259 | 28 | 0.108 | 0 |
| REV1 | REV1 | Q9UBZ9 | DNA repair protein REV1 | chr2 | GO:0006260 | Not Cancer Driver | No | 122 | 0.098 | 660 | 67 | 0.102 | 0 |
| RFC3 | RFC3 | P40938 | Replication factor C subunit 3 | chr13 | GO:0006260 | Not Cancer Driver | No | 31 | 0.087 | 13 | 1 | 0.077 | 0 |
| RFC5 | RFC5 | P40937 | Replication factor C subunit 5 | chr12 | GO:0006260 | Not Cancer Driver | No | 38 | 0.112 | 20 | 1 | 0.05 | 0 |
| RMI1 | RMI1 | Q9H9A7 | RecQ-mediated genome instability protein 1 | chr9 | GO:0006260 | Not Cancer Driver | No | 67 | 0.107 | 243 | 26 | 0.107 | 0 |
| RMI2 | RMI2 | Q96E14 | RecQ-mediated genome instability protein 2 | chr16 | GO:0006260 | Census | Yes | 12 | 0.082 | 86 | 5 | 0.058 | 0 |
| RNASEH2A | RNASEH2A | O75792 | Ribonuclease H2 subunit A | chr19 | GO:0006260 | Not Cancer Driver | No | 42 | 0.14 | 31 | 3 | 0.097 | 7 |
| RPA1 | RPA1 | P27694 | Replication protein A 70 kDa DNA-binding subunit | chr17 | GO:0006260 | Not Cancer Driver | No | 51 | 0.083 | 98 | 6 | 0.061 | 0 |
| RPA2_ENST00000373912 | RPA2 | P15927 | Replication protein A 32 kDa subunit | chr1 | GO:0006260 | Not Cancer Driver | No | 28 | 0.104 | 114 | 16 | 0.14 | 0 |
| RPA3 | RPA3 | P35244 | Replication protein A 14 kDa subunit | chr7 | GO:0006260 | Not Cancer Driver | No | 13 | 0.107 | 4 | 1 | 0.25 | 0 |
| RPA4 | RPA4 | Q13156 | Replication protein A 30 kDa subunit | chrX | GO:0006260 | Not Cancer Driver | No | 66 | 0.253 | 58 | 15 | 0.259 | 0 |
| RRM1 | RRM1 | P23921 | Ribonucleoside-diphosphate reductase large subunit | chr11 | GO:0006260 | Not Cancer Driver | No | 74 | 0.093 | 41 | 7 | 0.171 | 0 |
| RRM2B | RRM2B | Q7LG56 | Ribonucleoside-diphosphate reductase subunit M2 B | chr8 | GO:0006260 | Not Cancer Driver | No | 46 | 0.131 | 32 | 5 | 0.156 | 9 |
| RRM2_ENST00000641198 | RRM2 | P31350 | Ribonucleoside-diphosphate reductase subunit M2 | chr2 | GO:0006260 | Not Cancer Driver | No | 40 | 0.103 | 48 | 0 | 0.0 | 0 |
| SDE2 | SDE2 | Q6IQ49 | Replication stress response regulator SDE2 | chr1 | GO:0006260 | Not Cancer Driver | No | 56 | 0.124 | 290 | 35 | 0.121 | 0 |
| SET | SET | Q01105 | Protein SET | chr9 | GO:0006260 | Census, Compendium | Yes | 35 | 0.121 | 221 | 26 | 0.118 | 2 |
| SIN3A_ENST00000360439 | SIN3A | Q96ST3 | Paired amphipathic helix protein Sin3a | chr15 | GO:0006260 | Compendium | Yes | 172 | 0.135 | 617 | 73 | 0.118 | 0 |
| SLX4 | SLX4 | Q8IY92 | Structure-specific endonuclease subunit SLX4 | chr16 | GO:0006260 | Not Cancer Driver | No | 271 | 0.148 | 1573 | 232 | 0.147 | 0 |
| SSBP1_ENST00000484178 | SSBP1 | Q04837 | Single-stranded DNA-binding protein, mitochondrial | chr7 | GO:0006260 | Not Cancer Driver | No | 27 | 0.182 | 0 | 0 | 0.0 | 6 |
| SSRP1 | SSRP1 | Q08945 | FACT complex subunit SSRP1 | chr11 | GO:0006260 | Not Cancer Driver | No | 92 | 0.13 | 308 | 35 | 0.114 | 0 |
| STRA8 | STRA8 | Q7Z7C7 | Stimulated by retinoic acid gene 8 protein homolog | chr7 | GO:0006260 | Not Cancer Driver | No | 45 | 0.136 | 105 | 15 | 0.143 | 0 |
| SUPT16H | SUPT16H | Q9Y5B9 | FACT complex subunit SPT16 | chr14 | GO:0006260 | Not Cancer Driver | No | 147 | 0.14 | 301 | 44 | 0.146 | 0 |
| TBRG1 | TBRG1 | Q3YBR2 | Transforming growth factor beta regulator 1 | chr11 | GO:0006260 | Not Cancer Driver | No | 23 | 0.056 | 173 | 7 | 0.04 | 0 |
| TEFM | TEFM | Q96QE5 | Transcription elongation factor, mitochondrial | chr17 | GO:0006260 | Not Cancer Driver | No | 37 | 0.103 | 26 | 5 | 0.192 | 0 |
| TICRR | TICRR | Q7Z2Z1 | Treslin | chr15 | GO:0006260 | Not Cancer Driver | No | 201 | 0.105 | 1308 | 129 | 0.099 | 0 |
| TOP1 | TOP1 | P11387 | DNA topoisomerase 1 | chr20 | GO:0006260 | Census, Compendium | Yes | 93 | 0.122 | 391 | 53 | 0.136 | 0 |
| TOP1MT | TOP1MT | Q969P6 | DNA topoisomerase I, mitochondrial | chr8 | GO:0006260 | Not Cancer Driver | No | 102 | 0.17 | 171 | 32 | 0.187 | 0 |
| TREX1_ENST00000625293 | TREX1 | Q9NSU2 | Three-prime repair exonuclease 1 | chr3 | GO:0006260 | Not Cancer Driver | No | 26 | 0.083 | 98 | 10 | 0.102 | 18 |
| TWNK | TWNK | Q96RR1 | Twinkle mtDNA helicase | chr10 | GO:0006260 | Not Cancer Driver | No | 95 | 0.139 | 135 | 11 | 0.081 | 38 |
| UPF1 | UPF1 | Q92900 | Regulator of nonsense transcripts 1 | chr19 | GO:0006260 | Not Cancer Driver | No | 146 | 0.129 | 329 | 36 | 0.109 | 0 |
| WRN | WRN | Q14191 | Werner syndrome ATP-dependent helicase | chr8 | GO:0006260 | Census, Compendium | Yes | 164 | 0.115 | 373 | 41 | 0.11 | 2 |
| ZPR1 | ZPR1 | O75312 | Zinc finger protein ZPR1 | chr11 | GO:0006260 | Not Cancer Driver | No | 38 | 0.083 | 291 | 27 | 0.093 | 0 |