Filter in search result
Please select a valid state.

Total number of protein in "GO:0006259" GO term:  326

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
ACD_ENST00000620761 ACD Q96AP0 Adrenocortical dysplasia protein homolog chr16 GO:0006259 Not Cancer Driver No 49 0.107 256 34 0.133 1
ACTR5 ACTR5 Q9H9F9 Actin-related protein 5 chr20 GO:0006259 Not Cancer Driver No 63 0.104 163 23 0.141 0
ADPRHL2 ADPRS Q9NX46 ADP-ribosylhydrolase ARH3 chr1 GO:0006259 Not Cancer Driver No 32 0.088 49 4 0.082 1
AICDA AICDA Q9GZX7 Single-stranded DNA cytosine deaminase chr12 GO:0006259 Not Cancer Driver No 56 0.283 0 0 0.0 8
ALKBH1 ALKBH1 Q13686 Nucleic acid dioxygenase ALKBH1 chr14 GO:0006259 Not Cancer Driver No 55 0.141 77 11 0.143 0
ALKBH2_ENST00000343075 ALKBH2 Q6NS38 DNA oxidative demethylase ALKBH2 chr12 GO:0006259 Not Cancer Driver No 34 0.13 73 14 0.192 0
ALKBH3 ALKBH3 Q96Q83 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 chr11 GO:0006259 Not Cancer Driver No 42 0.147 157 25 0.159 0
ALKBH4 ALKBH4 Q9NXW9 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 chr7 GO:0006259 Not Cancer Driver No 39 0.129 14 2 0.143 0
APEX1_ENST00000555414 APEX1 P27695 DNA-(apurinic or apyrimidinic site) endonuclease chr14 GO:0006259 Not Cancer Driver No 34 0.107 103 14 0.136 0
APLF APLF Q8IW19 Aprataxin and PNK-like factor chr2 GO:0006259 Not Cancer Driver No 64 0.125 407 57 0.14 0
APOBEC1 APOBEC1 P41238 C->U-editing enzyme APOBEC-1 chr12 GO:0006259 Not Cancer Driver No 62 0.263 13 1 0.077 0
APOBEC2 APOBEC2 Q9Y235 C->U-editing enzyme APOBEC-2 chr6 GO:0006259 Not Cancer Driver No 38 0.17 36 3 0.083 0
APOBEC3A_ENST00000249116 APOBEC3A P31941 DNA dC->dU-editing enzyme APOBEC-3A chr22 GO:0006259 Not Cancer Driver No 27 0.136 8 1 0.125 0
APOBEC3B APOBEC3B Q9UH17 DNA dC->dU-editing enzyme APOBEC-3B chr22 GO:0006259 Census Yes 61 0.16 1 0 0.0 0
APOBEC3C APOBEC3C Q9NRW3 DNA dC->dU-editing enzyme APOBEC-3C chr22 GO:0006259 Not Cancer Driver No 28 0.147 2 0 0.0 0
APOBEC3D APOBEC3D Q96AK3 DNA dC->dU-editing enzyme APOBEC-3D chr22 GO:0006259 Not Cancer Driver No 43 0.111 3 0 0.0 0
APOBEC3F APOBEC3F Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F chr22 GO:0006259 Not Cancer Driver No 49 0.131 0 0 0.0 0
APOBEC3G APOBEC3G Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G chr22 GO:0006259 Not Cancer Driver No 61 0.159 0 0 0.0 0
APOBEC3H_ENST00000613677 APOBEC3H Q6NTF7 DNA dC->dU-editing enzyme APOBEC-3H chr22 GO:0006259 Not Cancer Driver No 39 0.195 0 0 0.0 0
APTX_ENST00000379819 APTX Q7Z2E3 Aprataxin chr9 GO:0006259 Not Cancer Driver No 36 0.101 101 6 0.059 9
ASCC3 ASCC3 Q8N3C0 Activating signal cointegrator 1 complex subunit 3 chr6 GO:0006259 Not Cancer Driver No 279 0.127 87 8 0.092 0
ASZ1 ASZ1 Q8WWH4 Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 chr7 GO:0006259 Not Cancer Driver No 86 0.181 53 10 0.189 0
ATAD5 ATAD5 Q96QE3 ATPase family AAA domain-containing protein 5 chr17 GO:0006259 Not Cancer Driver No 200 0.108 1075 112 0.104 0
ATF7IP_ENST00000540793 ATF7IP Q6VMQ6 Activating transcription factor 7-interacting protein 1 chr12 GO:0006259 Compendium Yes 160 0.126 1136 139 0.122 0
ATRX ATRX P46100 Transcriptional regulator ATRX chrX GO:0006259 Census, Compendium Yes 487 0.195 1672 301 0.18 33
AXIN2 AXIN2 Q9Y2T1 Axin-2 chr17 GO:0006259 Census, Compendium Yes 114 0.135 547 77 0.141 0
BANF1_ENST00000445560 BANF1 O75531 Barrier-to-autointegration factor chr11 GO:0006259 Not Cancer Driver No 10 0.112 11 2 0.182 1
BATF BATF Q16520 Basic leucine zipper transcriptional factor ATF-like chr14 GO:0006259 Not Cancer Driver No 28 0.224 119 25 0.21 0
BAZ2A BAZ2A Q9UIF9 Bromodomain adjacent to zinc finger domain protein 2A chr12 GO:0006259 Not Cancer Driver No 186 0.098 1283 118 0.092 0
BCL11B BCL11B Q9C0K0 B-cell lymphoma/leukemia 11B chr14 GO:0006259 Census, Compendium Yes 156 0.174 699 114 0.163 2
BEND3_ENST00000369042 BEND3 Q5T5X7 BEN domain-containing protein 3 chr6 GO:0006259 Not Cancer Driver No 104 0.126 311 44 0.141 0
BLM BLM P54132 Bloom syndrome protein chr15 GO:0006259 Census Yes 153 0.108 667 70 0.105 8
BRCA2_ENST00000544455 BRCA2 P51587 Breast cancer type 2 susceptibility protein chr13 GO:0006259 Census, Compendium Yes 457 0.134 1542 225 0.146 46
BRIP1 BRIP1 Q9BX63 Fanconi anemia group J protein chr17 GO:0006259 Census Yes 174 0.139 397 59 0.149 6
C14orf39 SIX6OS1 Q8N1H7 Protein SIX6OS1 chr14 GO:0006259 Not Cancer Driver No 128 0.218 326 76 0.233 0
C19orf57_ENST00000586783 BRME1 Q0VDD7 Break repair meiotic recombinase recruitment factor 1 chr19 GO:0006259 Not Cancer Driver No 91 0.136 632 88 0.139 0
CBS_ENST00000359624 CBS P35520 Cystathionine beta-synthase chr21 GO:0006259 Not Cancer Driver No 61 0.111 160 19 0.119 103
CCR6_ENST00000349984 CCR6 P51684 C-C chemokine receptor type 6 chr6 GO:0006259 Not Cancer Driver No 56 0.15 13 2 0.154 0
CD40LG CD40LG P29965 CD40 ligand chrX GO:0006259 Not Cancer Driver No 56 0.215 24 7 0.292 32
CDADC1 CDADC1 Q9BWV3 Cytidine and dCMP deaminase domain-containing protein 1 chr13 GO:0006259 Not Cancer Driver No 52 0.101 122 13 0.107 0
CECR2_ENST00000342247 CECR2 Q9BXF3 Cat eye syndrome critical region protein 2 chr22 GO:0006259 Not Cancer Driver No 222 0.15 1192 183 0.154 0
CNBP_ENST00000422453 CNBP P62633 CCHC-type zinc finger nucleic acid binding protein chr3 GO:0006259 Census Yes 11 0.062 19 0 0.0 0
CRY2_ENST00000616080 CRY2 Q49AN0 Cryptochrome-2 chr11 GO:0006259 Not Cancer Driver No 72 0.121 100 12 0.12 0
CTCF CTCF P49711 Transcriptional repressor CTCF chr16 GO:0006259 Census, Compendium Yes 151 0.208 481 83 0.173 1
CTCFL_ENST00000371196 CTCFL Q8NI51 Transcriptional repressor CTCFL chr20 GO:0006259 Not Cancer Driver No 136 0.205 266 61 0.229 0
CUL4B CUL4B Q13620 Cullin-4B chrX GO:0006259 Not Cancer Driver No 138 0.151 207 38 0.184 2
CYP1A1 CYP1A1 P04798 Cytochrome P450 1A1 chr15 GO:0006259 Not Cancer Driver No 81 0.158 17 2 0.118 0
CYP1B1 CYP1B1 Q16678 Cytochrome P450 1B1 chr2 GO:0006259 Not Cancer Driver No 61 0.112 31 3 0.097 40
CYREN CYREN Q9BWK5 Cell cycle regulator of non-homologous end joining chr7 GO:0006259 Not Cancer Driver No 24 0.153 128 19 0.148 0
DCLRE1A DCLRE1A Q6PJP8 DNA cross-link repair 1A protein chr10 GO:0006259 Not Cancer Driver No 92 0.088 514 45 0.088 0
DCLRE1B DCLRE1B Q9H816 5' exonuclease Apollo chr1 GO:0006259 Not Cancer Driver No 65 0.122 127 17 0.134 0
DCLRE1C DCLRE1C Q96SD1 Protein artemis chr10 GO:0006259 Not Cancer Driver No 76 0.11 277 26 0.094 3
DCTPP1 DCTPP1 Q9H773 dCTP pyrophosphatase 1 chr16 GO:0006259 Not Cancer Driver No 14 0.082 88 9 0.102 0
DDB1 DDB1 Q16531 DNA damage-binding protein 1 chr11 GO:0006259 Not Cancer Driver No 126 0.111 50 8 0.16 4
DDB2 DDB2 Q92466 DNA damage-binding protein 2 chr11 GO:0006259 Census, Compendium Yes 45 0.105 70 5 0.071 2
DDX21 DDX21 Q9NR30 Nucleolar RNA helicase 2 chr10 GO:0006259 Not Cancer Driver No 72 0.092 342 30 0.088 0
DDX23 DDX23 Q9BUQ8 Probable ATP-dependent RNA helicase DDX23 chr12 GO:0006259 Not Cancer Driver No 121 0.148 426 71 0.167 0
DDX4 DDX4 Q9NQI0 Probable ATP-dependent RNA helicase DDX4 chr5 GO:0006259 Not Cancer Driver No 115 0.159 315 49 0.156 0
DFFA DFFA O00273 DNA fragmentation factor subunit alpha chr1 GO:0006259 Not Cancer Driver No 47 0.142 113 18 0.159 0
DFFB_ENST00000378209 DFFB O76075 DNA fragmentation factor subunit beta chr1 GO:0006259 Not Cancer Driver No 37 0.109 27 1 0.037 0
DICER1 DICER1 Q9UPY3 Endoribonuclease Dicer chr14 GO:0006259 Census, Compendium Yes 264 0.137 362 45 0.124 4
DMAP1_ENST00000315913 DMAP1 Q9NPF5 DNA methyltransferase 1-associated protein 1 chr1 GO:0006259 Not Cancer Driver No 49 0.105 269 28 0.104 0
DMC1 DMC1 Q14565 Meiotic recombination protein DMC1/LIM15 homolog chr22 GO:0006259 Not Cancer Driver No 39 0.115 49 5 0.102 0
DNA2 DNA2 P51530 DNA replication ATP-dependent helicase/nuclease DNA2 chr10 GO:0006259 Not Cancer Driver No 120 0.113 52 8 0.154 3
DNASE1L1 DNASE1L1 P49184 Deoxyribonuclease-1-like 1 chrX GO:0006259 Not Cancer Driver No 30 0.099 0 0 0.0 0
DNASE1L2_ENST00000567494 DNASE1L2 Q92874 Deoxyribonuclease-1-like 2 chr16 GO:0006259 Not Cancer Driver No 23 0.077 15 1 0.067 0
DNASE1L3 DNASE1L3 Q13609 Deoxyribonuclease gamma chr3 GO:0006259 Not Cancer Driver No 43 0.141 15 4 0.267 0
DNASE2 DNASE2 O00115 Deoxyribonuclease-2-alpha chr19 GO:0006259 Not Cancer Driver No 46 0.128 48 7 0.146 0
DNASE2B DNASE2B Q8WZ79 Deoxyribonuclease-2-beta chr1 GO:0006259 Not Cancer Driver No 53 0.147 14 1 0.071 0
DNMT1_ENST00000340748 DNMT1 P26358 DNA (cytosine-5)-methyltransferase 1 chr19 GO:0006259 Not Cancer Driver No 203 0.126 702 78 0.111 4
DNMT3A DNMT3A Q9Y6K1 DNA (cytosine-5)-methyltransferase 3A chr2 GO:0006259 Census, Compendium Yes 194 0.213 371 59 0.159 16
DNMT3B DNMT3B Q9UBC3 DNA (cytosine-5)-methyltransferase 3B chr20 GO:0006259 Not Cancer Driver No 153 0.179 328 71 0.216 16
DNMT3L_ENST00000628202 DNMT3L Q9UJW3 DNA (cytosine-5)-methyltransferase 3-like chr21 GO:0006259 Not Cancer Driver No 83 0.215 10 1 0.1 0
DNTT DNTT P04053 DNA nucleotidylexotransferase chr10 GO:0006259 Not Cancer Driver No 106 0.208 66 16 0.242 0
DONSON DONSON Q9NYP3 Protein downstream neighbor of Son chr21 GO:0006259 Not Cancer Driver No 50 0.088 217 13 0.06 6
EHMT1 EHMT1 Q9H9B1 Histone-lysine N-methyltransferase EHMT1 chr9 GO:0006259 Not Cancer Driver No 182 0.14 701 97 0.138 1
EHMT2_ENST00000375537 EHMT2 Q96KQ7 Histone-lysine N-methyltransferase EHMT2 chr6 GO:0006259 Not Cancer Driver No 142 0.117 585 71 0.121 0
ENDOG ENDOG Q14249 Endonuclease G, mitochondrial chr9 GO:0006259 Not Cancer Driver No 11 0.037 61 1 0.016 0
ERCC1_ENST00000589165 ERCC1 P07992 DNA excision repair protein ERCC-1 chr19 GO:0006259 Not Cancer Driver No 42 0.141 105 14 0.133 1
ERCC2 ERCC2 P18074 General transcription and DNA repair factor IIH helicase subunit XPD chr19 GO:0006259 Census, Compendium Yes 150 0.197 5 0 0.0 35
ERCC3 ERCC3 P19447 General transcription and DNA repair factor IIH helicase subunit XPB chr2 GO:0006259 Census, Compendium Yes 92 0.118 208 22 0.106 2
ERCC4 ERCC4 Q92889 DNA repair endonuclease XPF chr16 GO:0006259 Census Yes 120 0.131 225 27 0.12 15
ERCC5 ERCC5 P28715 DNA excision repair protein ERCC-5 chr13 GO:0006259 Census Yes 175 0.148 816 121 0.148 6
ERCC6 ERCC6 Q03468 DNA excision repair protein ERCC-6 chr10 GO:0006259 Not Cancer Driver No 211 0.141 829 117 0.141 9
ERCC8 ERCC8 Q13216 DNA excision repair protein ERCC-8 chr5 GO:0006259 Not Cancer Driver No 25 0.063 53 8 0.151 7
EXO1_ENST00000348581 EXO1 Q9UQ84 Exonuclease 1 chr1 GO:0006259 Not Cancer Driver No 123 0.145 472 76 0.161 0
EXOG EXOG Q9Y2C4 Nuclease EXOG, mitochondrial chr3 GO:0006259 Not Cancer Driver No 42 0.114 52 1 0.019 0
EXOSC3 EXOSC3 Q9NQT5 Exosome complex component RRP40 chr9 GO:0006259 Not Cancer Driver No 18 0.065 54 2 0.037 4
EXOSC4 EXOSC4 Q9NPD3 Exosome complex component RRP41 chr8 GO:0006259 Not Cancer Driver No 34 0.139 23 0 0.0 0
EXOSC5 EXOSC5 Q9NQT4 Exosome complex component RRP46 chr19 GO:0006259 Not Cancer Driver No 43 0.183 31 3 0.097 0
EXOSC6 EXOSC6 Q5RKV6 Exosome complex component MTR3 chr16 GO:0006259 Not Cancer Driver No 3 0.011 102 0 0.0 0
EZH2_ENST00000460911 EZH2 Q15910 Histone-lysine N-methyltransferase EZH2 chr7 GO:0006259 Census, Compendium Yes 120 0.161 284 44 0.155 11
FAM111A FAM111A Q96PZ2 Serine protease FAM111A chr11 GO:0006259 Not Cancer Driver No 78 0.128 169 23 0.136 5
FANCB FANCB Q8NB91 Fanconi anemia group B protein chrX GO:0006259 Not Cancer Driver No 109 0.127 24 5 0.208 0
FANCD2_ENST00000383807 FANCD2 Q9BXW9 Fanconi anemia group D2 protein chr3 GO:0006259 Census, Compendium Yes 176 0.121 181 14 0.077 3
FANCM FANCM Q8IYD8 Fanconi anemia group M protein chr14 GO:0006259 Not Cancer Driver No 268 0.131 898 128 0.143 0
FBH1_ENST00000362091 FBH1 Q8NFZ0 F-box DNA helicase 1 chr10 GO:0006259 Not Cancer Driver No 139 0.133 192 32 0.167 0
FEN1 FEN1 P39748 Flap endonuclease 1 chr11 GO:0006259 Census Yes 35 0.092 111 11 0.099 0
FKBP6 FKBP6 O75344 Inactive peptidyl-prolyl cis-trans isomerase FKBP6 chr7 GO:0006259 Not Cancer Driver No 75 0.229 17 1 0.059 0
FOS FOS P01100 Protein c-Fos chr14 GO:0006259 Not Cancer Driver No 45 0.118 245 33 0.135 0
FOXL2 FOXL2 P58012 Forkhead box protein L2 chr3 GO:0006259 Census, Compendium Yes 39 0.104 257 20 0.078 26
FTO FTO Q9C0B1 Alpha-ketoglutarate-dependent dioxygenase FTO chr16 GO:0006259 Not Cancer Driver No 67 0.133 53 10 0.189 3
GATAD2A_ENST00000360315 GATAD2A Q86YP4 Transcriptional repressor p66-alpha chr19 GO:0006259 Not Cancer Driver No 88 0.139 548 77 0.141 0
GCNA GCNA Q96QF7 Germ cell nuclear acidic protein chrX GO:0006259 Not Cancer Driver No 155 0.224 513 122 0.238 0
GEN1_ENST00000381254 GEN1 Q17RS7 Flap endonuclease GEN homolog 1 chr2 GO:0006259 Not Cancer Driver No 109 0.12 339 52 0.153 0
GIN1 GIN1 Q9NXP7 Gypsy retrotransposon integrase-like protein 1 chr5 GO:0006259 Not Cancer Driver No 66 0.126 87 12 0.138 0
GINS1 GINS1 Q14691 DNA replication complex GINS protein PSF1 chr20 GO:0006259 Not Cancer Driver No 21 0.107 18 3 0.167 2
GINS3_ENST00000318129 GINS3 Q9BRX5 DNA replication complex GINS protein PSF3 chr16 GO:0006259 Not Cancer Driver No 36 0.167 14 0 0.0 0
GLRX2_ENST00000367439 GLRX2 Q9NS18 Glutaredoxin-2, mitochondrial chr1 GO:0006259 Not Cancer Driver No 12 0.073 10 1 0.1 0
HELLS_ENST00000348459 HELLS Q9NRZ9 Lymphoid-specific helicase chr10 GO:0006259 Not Cancer Driver No 78 0.093 227 25 0.11 0
HEMK1_ENST00000455834 HEMK1 Q9Y5R4 MTRF1L release factor glutamine methyltransferase chr3 GO:0006259 Not Cancer Driver No 36 0.107 14 0 0.0 0
HIST3H2A H2AW Q7L7L0 Histone H2A type 3 chr1 GO:0006259 Not Cancer Driver No 21 0.162 61 10 0.164 0
HMCES_ENST00000502878 HMCES Q96FZ2 Abasic site processing protein HMCES chr3 GO:0006259 Not Cancer Driver No 37 0.105 131 16 0.122 0
HMGB1_ENST00000405805 HMGB1 P09429 High mobility group protein B1 chr13 GO:0006259 Not Cancer Driver No 25 0.116 203 20 0.099 0
HMGB2 HMGB2 P26583 High mobility group protein B2 chr4 GO:0006259 Not Cancer Driver No 38 0.182 207 38 0.184 0
HSF2BP HSF2BP O75031 Heat shock factor 2-binding protein chr21 GO:0006259 Not Cancer Driver No 52 0.156 23 3 0.13 1
HSPD1 HSPD1 P10809 60 kDa heat shock protein, mitochondrial chr2 GO:0006259 Not Cancer Driver No 61 0.106 82 6 0.073 2
INO80_ENST00000401393 INO80 Q9ULG1 Chromatin-remodeling ATPase INO80 chr15 GO:0006259 Compendium Yes 173 0.111 682 76 0.111 0
ISG20 ISG20 Q96AZ6 Interferon-stimulated gene 20 kDa protein chr15 GO:0006259 Not Cancer Driver No 20 0.11 6 0 0.0 0
KDM1B_ENST00000449850 KDM1B Q8NB78 Lysine-specific histone demethylase 1B chr6 GO:0006259 Not Cancer Driver No 81 0.099 74 11 0.149 0
KMT2E KMT2E Q8IZD2 Inactive histone-lysine N-methyltransferase 2E chr7 GO:0006259 Not Cancer Driver No 233 0.125 1613 198 0.123 4
KPNA2_ENST00000330459 KPNA2 P52292 Importin subunit alpha-1 chr17 GO:0006259 Not Cancer Driver No 74 0.14 129 18 0.14 0
KRBA2_ENST00000331336 KRBA2 Q6ZNG9 KRAB-A domain-containing protein 2 chr17 GO:0006259 Not Cancer Driver No 56 0.114 150 18 0.12 0
LEF1 LEF1 Q9UJU2 Lymphoid enhancer-binding factor 1 chr4 GO:0006259 Census Yes 64 0.16 370 57 0.154 0
LIG1 LIG1 P18858 DNA ligase 1 chr19 GO:0006259 Not Cancer Driver No 137 0.149 397 62 0.156 0
LIG3 LIG3 P49916 DNA ligase 3 chr17 GO:0006259 Not Cancer Driver No 125 0.124 280 36 0.129 0
LIG4 LIG4 P49917 DNA ligase 4 chr13 GO:0006259 Not Cancer Driver No 134 0.147 63 10 0.159 2
LONP1 LONP1 P36776 Lon protease homolog, mitochondrial chr19 GO:0006259 Not Cancer Driver No 99 0.103 175 15 0.086 10
MAD2L2 MAD2L2 Q9UI95 Mitotic spindle assembly checkpoint protein MAD2B chr1 GO:0006259 Not Cancer Driver No 22 0.104 0 0 0.0 1
MAEL MAEL Q96JY0 Protein maelstrom homolog chr1 GO:0006259 Not Cancer Driver No 126 0.29 114 35 0.307 0
MBD4 MBD4 O95243 Methyl-CpG-binding domain protein 4 chr3 GO:0006259 Not Cancer Driver No 61 0.105 268 27 0.101 0
MC1R_ENST00000639847 MC1R Q01726 Melanocyte-stimulating hormone receptor chr16 GO:0006259 Not Cancer Driver No 39 0.123 0 0 0.0 5
MCM2 MCM2 P49736 DNA replication licensing factor MCM2 chr3 GO:0006259 Not Cancer Driver No 104 0.115 275 38 0.138 1
MCM3_ENST00000229854 MCM3 P25205 DNA replication licensing factor MCM3 chr6 GO:0006259 Not Cancer Driver No 92 0.114 310 47 0.152 0
MCM4 MCM4 P33991 DNA replication licensing factor MCM4 chr8 GO:0006259 Not Cancer Driver No 121 0.14 215 35 0.163 0
MCM8_ENST00000378896 MCM8 Q9UJA3 DNA helicase MCM8 chr20 GO:0006259 Not Cancer Driver No 94 0.112 188 19 0.101 1
MCM9_ENST00000619706 MCM9 Q9NXL9 DNA helicase MCM9 chr6 GO:0006259 Not Cancer Driver No 56 0.049 523 13 0.025 0
METTL4 METTL4 Q8N3J2 N(6)-adenine-specific methyltransferase METTL4 chr18 GO:0006259 Not Cancer Driver No 61 0.129 34 4 0.118 0
MGME1 MGME1 Q9BQP7 Mitochondrial genome maintenance exonuclease 1 chr20 GO:0006259 Not Cancer Driver No 33 0.096 95 7 0.074 1
MLH1 MLH1 P40692 DNA mismatch repair protein Mlh1 chr3 GO:0006259 Census Yes 92 0.122 208 22 0.106 85
MMS19 MMS19 Q96T76 MMS19 nucleotide excision repair protein homolog chr10 GO:0006259 Not Cancer Driver No 73 0.071 11 0 0.0 0
MORC1 MORC1 Q86VD1 MORC family CW-type zinc finger protein 1 chr3 GO:0006259 Not Cancer Driver No 300 0.305 252 77 0.306 0
MOV10L1_ENST00000545383 MOV10L1 Q9BXT6 RNA helicase Mov10l1 chr22 GO:0006259 Not Cancer Driver No 184 0.152 178 21 0.118 0
MPG MPG P29372 DNA-3-methyladenine glycosylase chr16 GO:0006259 Not Cancer Driver No 35 0.117 141 21 0.149 0
MRE11 MRE11 P49959 Double-strand break repair protein MRE11 chr11 GO:0006259 Not Cancer Driver No 84 0.119 292 35 0.12 1
MSH2 MSH2 P43246 DNA mismatch repair protein Msh2 chr2 GO:0006259 Census Yes 92 0.099 37 4 0.108 70
MSH3 MSH3 P20585 DNA mismatch repair protein Msh3 chr5 GO:0006259 Not Cancer Driver No 100 0.088 211 20 0.095 0
MSH6 MSH6 P52701 DNA mismatch repair protein Msh6 chr2 GO:0006259 Census Yes 154 0.113 386 41 0.106 6
MTA2 MTA2 O94776 Metastasis-associated protein MTA2 chr11 GO:0006259 Not Cancer Driver No 78 0.117 283 32 0.113 0
MTRR_ENST00000440940 MTRR Q9UBK8 Methionine synthase reductase chr5 GO:0006259 Not Cancer Driver No 101 0.145 84 13 0.155 5
MUTYH MUTYH Q9UIF7 Adenine DNA glycosylase chr1 GO:0006259 Census Yes 90 0.165 198 29 0.146 23
MYO18A MYO18A Q92614 Unconventional myosin-XVIIIa chr17 GO:0006259 Not Cancer Driver No 268 0.13 1237 176 0.142 0
N6AMT1 N6AMT1 Q9Y5N5 Methyltransferase N6AMT1 chr21 GO:0006259 Not Cancer Driver No 44 0.206 20 3 0.15 0
NBN NBN O60934 Nibrin chr8 GO:0006259 Census Yes 90 0.119 417 54 0.129 1
NEIL1_ENST00000564784 NEIL1 Q96FI4 Endonuclease 8-like 1 chr15 GO:0006259 Not Cancer Driver No 41 0.105 165 14 0.085 0
NEIL2 NEIL2 Q969S2 Endonuclease 8-like 2 chr8 GO:0006259 Not Cancer Driver No 31 0.093 145 14 0.097 0
NEIL3 NEIL3 Q8TAT5 Endonuclease 8-like 3 chr4 GO:0006259 Not Cancer Driver No 80 0.132 131 18 0.137 0
NHEJ1 NHEJ1 Q9H9Q4 Non-homologous end-joining factor 1 chr2 GO:0006259 Not Cancer Driver No 35 0.117 83 8 0.096 2
NIPBL NIPBL Q6KC79 Nipped-B-like protein chr5 GO:0006259 Compendium Yes 353 0.126 1528 184 0.12 37
NME1_ENST00000393196 NME1 P15531 Nucleoside diphosphate kinase A chr17 GO:0006259 Not Cancer Driver No 11 0.072 10 0 0.0 0
NSMCE2_ENST00000522563 NSMCE2 Q96MF7 E3 SUMO-protein ligase NSE2 chr8 GO:0006259 Not Cancer Driver No 30 0.121 119 12 0.101 0
NT5E NT5E P21589 5'-nucleotidase chr6 GO:0006259 Not Cancer Driver No 61 0.106 26 2 0.077 1
NTHL1 NTHL1 P78549 Endonuclease III-like protein 1 chr16 GO:0006259 Census Yes 38 0.122 147 18 0.122 0
NUCKS1 NUCKS1 Q9H1E3 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 chr1 GO:0006259 Not Cancer Driver No 30 0.123 243 30 0.123 0
NUDT15 NUDT15 Q9NV35 Nucleotide triphosphate diphosphatase NUDT15 chr13 GO:0006259 Not Cancer Driver No 24 0.146 37 3 0.081 0
NUDT1_ENST00000397046 NUDT1 P36639 Oxidized purine nucleoside triphosphate hydrolase chr7 GO:0006259 Not Cancer Driver No 25 0.16 17 4 0.235 0
NYNRIN NYNRIN Q9P2P1 Protein NYNRIN chr14 GO:0006259 Not Cancer Driver No 250 0.132 636 70 0.11 0
OGG1_ENST00000344629 OGG1 O15527 N-glycosylase/DNA lyase chr3 GO:0006259 Not Cancer Driver No 37 0.107 71 12 0.169 0
PARG_ENST00000616448 PARG Q86W56 Poly(ADP-ribose) glycohydrolase chr10 GO:0006259 Not Cancer Driver No 60 0.061 519 1 0.002 0
PARP1 PARP1 P09874 Poly [ADP-ribose] polymerase 1 chr1 GO:0006259 Not Cancer Driver No 119 0.117 320 34 0.106 0
PARP2 PARP2 Q9UGN5 Poly [ADP-ribose] polymerase 2 chr14 GO:0006259 Not Cancer Driver No 74 0.127 172 23 0.134 0
PARP3_ENST00000431474 PARP3 Q9Y6F1 Protein mono-ADP-ribosyltransferase PARP3 chr3 GO:0006259 Not Cancer Driver No 70 0.131 269 38 0.141 0
PCNA PCNA P12004 Proliferating cell nuclear antigen chr20 GO:0006259 Not Cancer Driver No 30 0.115 22 3 0.136 1
PGBD5 PGBD5 Q8N414 PiggyBac transposable element-derived protein 5 chr1 GO:0006259 Not Cancer Driver No 73 0.139 126 1 0.008 0
PICK1 PICK1 Q9NRD5 PRKCA-binding protein chr22 GO:0006259 Not Cancer Driver No 50 0.12 49 3 0.061 0
PIWIL2_ENST00000454009 PIWIL2 Q8TC59 Piwi-like protein 2 chr8 GO:0006259 Not Cancer Driver No 138 0.142 232 38 0.164 0
PIWIL4 PIWIL4 Q7Z3Z4 Piwi-like protein 4 chr11 GO:0006259 Not Cancer Driver No 115 0.135 89 11 0.124 0
PLD3_ENST00000409735 PLD3 Q8IV08 5'-3' exonuclease PLD3 chr19 GO:0006259 Not Cancer Driver No 70 0.143 62 7 0.113 0
PLD4_ENST00000392593 PLD4 Q96BZ4 5'-3' exonuclease PLD4 chr14 GO:0006259 Not Cancer Driver No 46 0.091 76 10 0.132 0
PLD6 PLD6 Q8N2A8 Mitochondrial cardiolipin hydrolase chr17 GO:0006259 Not Cancer Driver No 27 0.107 24 6 0.25 0
PNKP PNKP Q96T60 Bifunctional polynucleotide phosphatase/kinase chr19 GO:0006259 Not Cancer Driver No 53 0.102 177 23 0.13 4
POLA1_ENST00000379059 POLA1 P09884 DNA polymerase alpha catalytic subunit chrX GO:0006259 Not Cancer Driver No 185 0.127 347 45 0.13 3
POLB POLB P06746 DNA polymerase beta chr8 GO:0006259 Not Cancer Driver No 43 0.128 87 11 0.126 0
POLD1_ENST00000440232 POLD1 P28340 DNA polymerase delta catalytic subunit chr19 GO:0006259 Census, Compendium Yes 179 0.162 214 31 0.145 2
POLD2_ENST00000452185 POLD2 P49005 DNA polymerase delta subunit 2 chr7 GO:0006259 Not Cancer Driver No 49 0.104 65 3 0.046 0
POLD3 POLD3 Q15054 DNA polymerase delta subunit 3 chr11 GO:0006259 Not Cancer Driver No 51 0.109 326 39 0.12 0
POLDIP2 POLDIP2 Q9Y2S7 Polymerase delta-interacting protein 2 chr17 GO:0006259 Not Cancer Driver No 36 0.098 94 13 0.138 0
POLE POLE Q07864 DNA polymerase epsilon catalytic subunit A chr12 GO:0006259 Census, Compendium Yes 409 0.179 239 44 0.184 3
POLE2 POLE2 P56282 DNA polymerase epsilon subunit 2 chr14 GO:0006259 Not Cancer Driver No 53 0.101 32 2 0.062 0
POLE3 POLE3 Q9NRF9 DNA polymerase epsilon subunit 3 chr9 GO:0006259 Not Cancer Driver No 11 0.075 117 9 0.077 0
POLG2 POLG2 Q9UHN1 DNA polymerase subunit gamma-2, mitochondrial chr17 GO:0006259 Not Cancer Driver No 64 0.132 46 4 0.087 3
POLG_ENST00000442287 POLG P54098 DNA polymerase subunit gamma-1 chr15 GO:0006259 Census Yes 139 0.112 421 42 0.1 73
POLH POLH Q9Y253 DNA polymerase eta chr6 GO:0006259 Not Cancer Driver No 72 0.101 291 20 0.069 10
POLI POLI Q9UNA4 DNA polymerase iota chr18 GO:0006259 Not Cancer Driver No 82 0.111 300 32 0.107 0
POLK POLK Q9UBT6 DNA polymerase kappa chr5 GO:0006259 Not Cancer Driver No 97 0.111 293 36 0.123 0
POLL_ENST00000370169 POLL Q9UGP5 DNA polymerase lambda chr10 GO:0006259 Not Cancer Driver No 69 0.12 215 16 0.074 0
POLQ POLQ O75417 DNA polymerase theta chr3 GO:0006259 Census, Compendium Yes 364 0.141 949 135 0.142 0
POLR2I POLR2I P36954 DNA-directed RNA polymerase II subunit RPB9 chr19 GO:0006259 Not Cancer Driver No 21 0.168 22 5 0.227 0
POT1 POT1 Q9NUX5 Protection of telomeres protein 1 chr7 GO:0006259 Census, Compendium Yes 113 0.178 31 6 0.194 9
PPM1D PPM1D O15297 Protein phosphatase 1D chr17 GO:0006259 Census, Compendium Yes 54 0.089 370 32 0.086 0
PRDM9 PRDM9 Q9NQV7 Histone-lysine N-methyltransferase PRDM9 chr5 GO:0006259 Not Cancer Driver No 494 0.553 372 201 0.54 0
PRIMPOL_ENST00000503752 PRIMPOL Q96LW4 DNA-directed primase/polymerase protein chr4 GO:0006259 Not Cancer Driver No 50 0.089 92 7 0.076 0
PRKDC PRKDC P78527 DNA-dependent protein kinase catalytic subunit chr8 GO:0006259 Not Cancer Driver No 538 0.13 421 61 0.145 2
PRMT7_ENST00000441236 PRMT7 Q9NVM4 Protein arginine N-methyltransferase 7 chr16 GO:0006259 Not Cancer Driver No 71 0.103 39 1 0.026 3
PSMC3IP PSMC3IP Q9P2W1 Homologous-pairing protein 2 homolog chr17 GO:0006259 Not Cancer Driver No 25 0.115 73 8 0.11 0
RAD21 RAD21 O60216 Double-strand-break repair protein rad21 homolog chr8 GO:0006259 Census, Compendium Yes 115 0.182 421 74 0.176 3
RAD21L1 RAD21L1 Q9H4I0 Double-strand-break repair protein rad21-like protein 1 chr20 GO:0006259 Not Cancer Driver No 37 0.067 186 5 0.027 0
RAD50 RAD50 Q92878 DNA repair protein RAD50 chr5 GO:0006259 Not Cancer Driver No 157 0.12 730 84 0.115 0
RAD51C RAD51C O43502 DNA repair protein RAD51 homolog 3 chr17 GO:0006259 Not Cancer Driver No 47 0.125 18 2 0.111 6
RAD51D_ENST00000394589 RAD51D O75771 DNA repair protein RAD51 homolog 4 chr17 GO:0006259 Not Cancer Driver No 34 0.104 49 10 0.204 0
RAD51_ENST00000267868 RAD51 Q06609 DNA repair protein RAD51 homolog 1 chr15 GO:0006259 Not Cancer Driver No 42 0.124 47 5 0.106 3
RAD52 RAD52 P43351 DNA repair protein RAD52 homolog chr12 GO:0006259 Not Cancer Driver No 41 0.098 251 30 0.12 0
RAD54L_ENST00000442598 RAD54L Q92698 DNA repair and recombination protein RAD54-like chr1 GO:0006259 Not Cancer Driver No 79 0.106 124 13 0.105 0
RAN_ENST00000392369 RAN P62826 GTP-binding nuclear protein Ran chr12 GO:0006259 Not Cancer Driver No 20 0.093 14 1 0.071 0
RBBP8_ENST00000327155 RBBP8 Q99708 DNA endonuclease RBBP8 chr18 GO:0006259 Not Cancer Driver No 99 0.11 750 76 0.101 1
RCHY1 RCHY1 Q96PM5 RING finger and CHY zinc finger domain-containing protein 1 chr4 GO:0006259 Not Cancer Driver No 33 0.126 23 0 0.0 0
REC8_ENST00000611366 REC8 O95072 Meiotic recombination protein REC8 homolog chr14 GO:0006259 Not Cancer Driver No 60 0.11 244 26 0.107 0
RECQL4 RECQL4 O94761 ATP-dependent DNA helicase Q4 chr8 GO:0006259 Census, Compendium Yes 138 0.114 608 71 0.117 1
RECQL5 RECQL5 O94762 ATP-dependent DNA helicase Q5 chr17 GO:0006259 Not Cancer Driver No 132 0.133 495 71 0.143 0
REV1 REV1 Q9UBZ9 DNA repair protein REV1 chr2 GO:0006259 Not Cancer Driver No 122 0.098 660 67 0.102 0
REV3L_ENST00000368802 REV3L O60673 DNA polymerase zeta catalytic subunit chr6 GO:0006259 Not Cancer Driver No 379 0.121 1665 211 0.127 0
REXO2 REXO2 Q9Y3B8 Oligoribonuclease, mitochondrial chr11 GO:0006259 Not Cancer Driver No 19 0.08 43 4 0.093 0
REXO4 REXO4 Q9GZR2 RNA exonuclease 4 chr9 GO:0006259 Not Cancer Driver No 34 0.081 298 26 0.087 0
RIF1 RIF1 Q5UIP0 Telomere-associated protein RIF1 chr2 GO:0006259 Not Cancer Driver No 287 0.116 1355 164 0.121 0
RMI1 RMI1 Q9H9A7 RecQ-mediated genome instability protein 1 chr9 GO:0006259 Not Cancer Driver No 67 0.107 243 26 0.107 0
RMI2 RMI2 Q96E14 RecQ-mediated genome instability protein 2 chr16 GO:0006259 Census Yes 12 0.082 86 5 0.058 0
RNF111_ENST00000557998 RNF111 Q6ZNA4 E3 ubiquitin-protein ligase Arkadia chr15 GO:0006259 Not Cancer Driver No 111 0.112 855 96 0.112 0
RNF138 RNF138 Q8WVD3 E3 ubiquitin-protein ligase RNF138 chr18 GO:0006259 Not Cancer Driver No 44 0.18 34 6 0.176 0
RNF168 RNF168 Q8IYW5 E3 ubiquitin-protein ligase RNF168 chr3 GO:0006259 Not Cancer Driver No 77 0.135 471 66 0.14 0
RNF212 RNF212 Q495C1 Probable E3 SUMO-protein ligase RNF212 chr4 GO:0006259 Not Cancer Driver No 36 0.121 58 12 0.207 0
RNF8 RNF8 O76064 E3 ubiquitin-protein ligase RNF8 chr6 GO:0006259 Not Cancer Driver No 56 0.115 226 29 0.128 0
RTEL1_ENST00000370018 RTEL1 Q9NZ71 Regulator of telomere elongation helicase 1 chr20 GO:0006259 Not Cancer Driver No 144 0.118 474 64 0.135 14
RTF2_ENST00000357348 RTF2 Q9BY42 Replication termination factor 2 chr20 GO:0006259 Not Cancer Driver No 44 0.144 170 22 0.129 0
SAMHD1 SAMHD1 Q9Y3Z3 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 chr20 GO:0006259 Not Cancer Driver No 104 0.166 91 14 0.154 13
SESN2 SESN2 P58004 Sestrin-2 chr1 GO:0006259 Not Cancer Driver No 74 0.154 147 26 0.177 0
SETMAR SETMAR Q53H47 Histone-lysine N-methyltransferase SETMAR chr3 GO:0006259 Not Cancer Driver No 62 0.091 154 12 0.078 0
SIRT1 SIRT1 Q96EB6 NAD-dependent protein deacetylase sirtuin-1 chr10 GO:0006259 Not Cancer Driver No 70 0.094 435 31 0.071 0
SIRT7 SIRT7 Q9NRC8 NAD-dependent protein deacetylase sirtuin-7 chr17 GO:0006259 Not Cancer Driver No 48 0.12 163 15 0.092 0
SLFN11_ENST00000308377 SLFN11 Q7Z7L1 Schlafen family member 11 chr17 GO:0006259 Not Cancer Driver No 177 0.196 34 8 0.235 0
SLX1B SLX1B Q9BQ83 Structure-specific endonuclease subunit SLX1 chr16 GO:0006259 Not Cancer Driver No 3 0.011 80 1 0.013 0
SLX4 SLX4 Q8IY92 Structure-specific endonuclease subunit SLX4 chr16 GO:0006259 Not Cancer Driver No 271 0.148 1573 232 0.147 0
SMARCAL1 SMARCAL1 Q9NZC9 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 chr2 GO:0006259 Not Cancer Driver No 128 0.134 335 49 0.146 11
SMARCB1_ENST00000644036 SMARCB1 Q12824 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 chr22 GO:0006259 Census, Compendium Yes 64 0.166 141 35 0.248 3
SMC5 SMC5 Q8IY18 Structural maintenance of chromosomes protein 5 chr9 GO:0006259 Not Cancer Driver No 126 0.114 378 43 0.114 0
SMC6_ENST00000351948 SMC6 Q96SB8 Structural maintenance of chromosomes protein 6 chr2 GO:0006259 Not Cancer Driver No 128 0.117 458 57 0.124 0
SMUG1 SMUG1 Q53HV7 Single-strand selective monofunctional uracil DNA glycosylase chr12 GO:0006259 Not Cancer Driver No 33 0.122 46 2 0.043 0
SPATA22_ENST00000397168 SPATA22 Q8NHS9 Spermatogenesis-associated protein 22 chr17 GO:0006259 Not Cancer Driver No 71 0.196 220 40 0.182 0
SPO11 SPO11 Q9Y5K1 Meiotic recombination protein SPO11 chr20 GO:0006259 Not Cancer Driver No 59 0.149 26 5 0.192 0
SPOCD1 SPOCD1 Q6ZMY3 SPOC domain-containing protein 1 chr1 GO:0006259 Not Cancer Driver No 158 0.13 877 113 0.129 0
SPRTN SPRTN Q9H040 DNA-dependent metalloprotease SPRTN chr1 GO:0006259 Not Cancer Driver No 73 0.149 252 38 0.151 1
SRPK2_ENST00000489828 SRPK2 P78362 SRSF protein kinase 2 chr7 GO:0006259 Not Cancer Driver No 78 0.113 343 46 0.134 0
STPG4 STPG4 Q8N801 Protein STPG4 chr2 GO:0006259 Not Cancer Driver No 32 0.129 132 17 0.129 0
SWAP70 SWAP70 Q9UH65 Switch-associated protein 70 chr11 GO:0006259 Not Cancer Driver No 44 0.075 271 18 0.066 0
SYCP1_ENST00000618516 SYCP1 Q15431 Synaptonemal complex protein 1 chr1 GO:0006259 Not Cancer Driver No 207 0.212 602 124 0.206 0
TATDN1 TATDN1 Q6P1N9 Deoxyribonuclease TATDN1 chr8 GO:0006259 Not Cancer Driver No 25 0.084 0 0 0.0 0
TCF3 TCF3 P15923 Transcription factor E2-alpha chr19 GO:0006259 Census Yes 52 0.08 649 52 0.08 0
TCF7L2_ENST00000355995 TCF7L2 Q9NQB0 Transcription factor 7-like 2 chr10 GO:0006259 Census, Compendium Yes 122 0.197 516 93 0.18 0
TDG TDG Q13569 G/T mismatch-specific thymine DNA glycosylase chr12 GO:0006259 Not Cancer Driver No 75 0.183 185 31 0.168 0
TDP1_ENST00000393454 TDP1 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 chr14 GO:0006259 Not Cancer Driver No 81 0.133 179 25 0.14 1
TDRD1 TDRD1 Q9BXT4 Tudor domain-containing protein 1 chr10 GO:0006259 Not Cancer Driver No 200 0.169 216 27 0.125 0
TDRD12_ENST00000444215 TDRD12 Q587J7 Putative ATP-dependent RNA helicase TDRD12 chr19 GO:0006259 Not Cancer Driver No 36 0.031 220 10 0.045 0
TDRD5_ENST00000294848 TDRD5 Q8NAT2 Tudor domain-containing protein 5 chr1 GO:0006259 Not Cancer Driver No 231 0.235 343 74 0.216 0
TDRD9 TDRD9 Q8NDG6 ATP-dependent RNA helicase TDRD9 chr14 GO:0006259 Not Cancer Driver No 156 0.113 108 0 0.0 0
TDRKH_ENST00000368827 TDRKH Q9Y2W6 Tudor and KH domain-containing protein chr1 GO:0006259 Not Cancer Driver No 76 0.135 185 27 0.146 0
TEP1 TEP1 Q99973 Telomerase protein component 1 chr14 GO:0006259 Not Cancer Driver No 332 0.126 396 67 0.169 0
TERF1 TERF1 P54274 Telomeric repeat-binding factor 1 chr8 GO:0006259 Not Cancer Driver No 63 0.144 220 34 0.155 0
TERF2 TERF2 Q15554 Telomeric repeat-binding factor 2 chr16 GO:0006259 Not Cancer Driver No 33 0.061 361 20 0.055 0
TERF2IP TERF2IP Q9NYB0 Telomeric repeat-binding factor 2-interacting protein 1 chr16 GO:0006259 Not Cancer Driver No 28 0.07 310 16 0.052 0
TERT TERT O14746 Telomerase reverse transcriptase chr5 GO:0006259 Census Yes 110 0.097 212 16 0.075 31
TET1 TET1 Q8NFU7 Methylcytosine dioxygenase TET1 chr10 GO:0006259 Census, Compendium Yes 316 0.148 1551 234 0.151 0
TET2 TET2 Q6N021 Methylcytosine dioxygenase TET2 chr4 GO:0006259 Census, Compendium Yes 191 0.095 1663 176 0.106 1
TET3 TET3 O43151 Methylcytosine dioxygenase TET3 chr2 GO:0006259 Not Cancer Driver No 208 0.116 1272 152 0.119 6
TEX11_ENST00000344304 TEX11 Q8IYF3 Testis-expressed protein 11 chrX GO:0006259 Not Cancer Driver No 139 0.148 30 3 0.1 2
TEX12 TEX12 Q9BXU0 Testis-expressed protein 12 chr11 GO:0006259 Not Cancer Driver No 10 0.081 35 3 0.086 0
TEX15_ENST00000256246 TEX15 Q9BXT5 Testis-expressed protein 15 chr8 GO:0006259 Not Cancer Driver No 479 0.172 1258 223 0.177 0
TEX264_ENST00000416589 TEX264 Q9Y6I9 Testis-expressed protein 264 chr3 GO:0006259 Not Cancer Driver No 40 0.128 107 11 0.103 0
TFIP11_ENST00000407148 TFIP11 Q9UBB9 Tuftelin-interacting protein 11 chr22 GO:0006259 Not Cancer Driver No 87 0.104 331 39 0.118 0
THAP9 THAP9 Q9H5L6 DNA transposase THAP9 chr4 GO:0006259 Not Cancer Driver No 82 0.091 46 6 0.13 0
TIMELESS TIMELESS Q9UNS1 Protein timeless homolog chr12 GO:0006259 Not Cancer Driver No 154 0.127 367 51 0.139 0
TIPIN TIPIN Q9BVW5 TIMELESS-interacting protein chr15 GO:0006259 Not Cancer Driver No 26 0.086 242 19 0.079 0
TNP1 TNP1 P09430 Spermatid nuclear transition protein 1 chr2 GO:0006259 Not Cancer Driver No 21 0.382 55 21 0.382 0
TOP1 TOP1 P11387 DNA topoisomerase 1 chr20 GO:0006259 Census, Compendium Yes 93 0.122 391 53 0.136 0
TOP1MT TOP1MT Q969P6 DNA topoisomerase I, mitochondrial chr8 GO:0006259 Not Cancer Driver No 102 0.17 171 32 0.187 0
TOP2A TOP2A P11388 DNA topoisomerase 2-alpha chr17 GO:0006259 Compendium Yes 150 0.098 508 59 0.116 0
TOP2B TOP2B Q02880 DNA topoisomerase 2-beta chr3 GO:0006259 Not Cancer Driver No 154 0.095 543 46 0.085 0
TOP3A TOP3A Q13472 DNA topoisomerase 3-alpha chr17 GO:0006259 Not Cancer Driver No 103 0.103 293 31 0.106 2
TOP3B_ENST00000357179 TOP3B O95985 DNA topoisomerase 3-beta-1 chr22 GO:0006259 Not Cancer Driver No 102 0.118 151 17 0.113 0
TOPBP1 TOPBP1 Q92547 DNA topoisomerase 2-binding protein 1 chr3 GO:0006259 Not Cancer Driver No 169 0.111 577 59 0.102 0
TP53_ENST00000445888 TP53 P04637 Cellular tumor antigen p53 chr17 GO:0006259 Census, Compendium Yes 2891 7.356 282 1466 5.199 83
TPRKB_ENST00000272424 TPRKB Q9Y3C4 EKC/KEOPS complex subunit TPRKB chr2 GO:0006259 Not Cancer Driver No 20 0.114 0 0 0.0 2
TRAIP TRAIP Q9BWF2 E3 ubiquitin-protein ligase TRAIP chr3 GO:0006259 Not Cancer Driver No 63 0.134 240 33 0.138 1
TREX1_ENST00000625293 TREX1 Q9NSU2 Three-prime repair exonuclease 1 chr3 GO:0006259 Not Cancer Driver No 26 0.083 98 10 0.102 18
TREX2_ENST00000370231 TREX2 Q9BQ50 Three prime repair exonuclease 2 chrX GO:0006259 Not Cancer Driver No 33 0.14 23 6 0.261 0
TRIM28 TRIM28 Q13263 Transcription intermediary factor 1-beta chr19 GO:0006259 Not Cancer Driver No 87 0.104 430 41 0.095 0
UBE2V2 UBE2V2 Q15819 Ubiquitin-conjugating enzyme E2 variant 2 chr8 GO:0006259 Not Cancer Driver No 22 0.152 76 12 0.158 0
UHRF1_ENST00000616255 UHRF1 Q96T88 E3 ubiquitin-protein ligase UHRF1 chr19 GO:0006259 Not Cancer Driver No 97 0.122 353 49 0.139 0
UHRF2 UHRF2 Q96PU4 E3 ubiquitin-protein ligase UHRF2 chr9 GO:0006259 Not Cancer Driver No 88 0.11 253 22 0.087 0
UNG UNG P13051 Uracil-DNA glycosylase chr12 GO:0006259 Not Cancer Driver No 34 0.109 96 13 0.135 1
UPF1 UPF1 Q92900 Regulator of nonsense transcripts 1 chr19 GO:0006259 Not Cancer Driver No 146 0.129 329 36 0.109 0
USP45 USP45 Q70EL2 Ubiquitin carboxyl-terminal hydrolase 45 chr6 GO:0006259 Not Cancer Driver No 96 0.118 275 28 0.102 0
USP7 USP7 Q93009 Ubiquitin carboxyl-terminal hydrolase 7 chr16 GO:0006259 Not Cancer Driver No 170 0.154 215 45 0.209 0
UVRAG UVRAG Q9P2Y5 UV radiation resistance-associated gene protein chr11 GO:0006259 Not Cancer Driver No 89 0.127 243 28 0.115 0
UVSSA UVSSA Q2YD98 UV-stimulated scaffold protein A chr4 GO:0006259 Not Cancer Driver No 101 0.142 519 70 0.135 1
VCP VCP P55072 Transitional endoplasmic reticulum ATPase chr9 GO:0006259 Not Cancer Driver No 88 0.109 186 16 0.086 16
VCPIP1 VCPIP1 Q96JH7 Deubiquitinating protein VCPIP1 chr8 GO:0006259 Not Cancer Driver No 133 0.109 543 61 0.112 0
VRTN VRTN Q9H8Y1 Vertnin chr14 GO:0006259 Not Cancer Driver No 153 0.218 132 27 0.205 0
WRN WRN Q14191 Werner syndrome ATP-dependent helicase chr8 GO:0006259 Census, Compendium Yes 164 0.115 373 41 0.11 2
XAB2 XAB2 Q9HCS7 Pre-mRNA-splicing factor SYF1 chr19 GO:0006259 Not Cancer Driver No 128 0.15 127 17 0.134 0
XPA XPA P23025 DNA repair protein complementing XP-A cells chr9 GO:0006259 Census Yes 27 0.099 121 13 0.107 5
XPC XPC Q01831 DNA repair protein complementing XP-C cells chr3 GO:0006259 Census, Compendium Yes 88 0.094 479 48 0.1 2
XRCC1 XRCC1 P18887 DNA repair protein XRCC1 chr19 GO:0006259 Not Cancer Driver No 85 0.134 426 53 0.124 1
XRCC2 XRCC2 O43543 DNA repair protein XRCC2 chr7 GO:0006259 Not Cancer Driver No 36 0.129 9 1 0.111 2
XRCC3_ENST00000352127 XRCC3 O43542 DNA repair protein XRCC3 chr14 GO:0006259 Not Cancer Driver No 24 0.069 35 2 0.057 1
XRCC4 XRCC4 Q13426 DNA repair protein XRCC4 chr5 GO:0006259 Not Cancer Driver No 47 0.14 171 31 0.181 3
XRCC6 XRCC6 P12956 X-ray repair cross-complementing protein 6 chr22 GO:0006259 Not Cancer Driver No 66 0.108 140 12 0.086 0
XRN2 XRN2 Q9H0D6 5'-3' exoribonuclease 2 chr20 GO:0006259 Not Cancer Driver No 129 0.136 427 63 0.148 0
YY1 YY1 P25490 Transcriptional repressor protein YY1 chr14 GO:0006259 Not Cancer Driver No 37 0.089 336 26 0.077 2
ZBED9 ZBED9 Q6R2W3 SCAN domain-containing protein 3 chr6 GO:0006259 Not Cancer Driver No 333 0.251 317 84 0.265 0
ZBTB7A_ENST00000601588 ZBTB7A O95365 Zinc finger and BTB domain-containing protein 7A chr19 GO:0006259 Not Cancer Driver No 60 0.103 285 30 0.105 0
ZDBF2 ZDBF2 Q9HCK1 DBF4-type zinc finger-containing protein 2 chr2 GO:0006259 Not Cancer Driver No 510 0.217 1664 380 0.228 0
ZFP57_ENST00000376881 ZFP57 Q9NU63 Zinc finger protein 57 homolog chr6 GO:0006259 Not Cancer Driver No 82 0.181 153 33 0.216 3
ZGRF1 ZGRF1 Q86YA3 Protein ZGRF1 chr4 GO:0006259 Not Cancer Driver No 216 0.103 881 95 0.108 0
ZMPSTE24 ZMPSTE24 O75844 CAAX prenyl protease 1 homolog chr1 GO:0006259 Not Cancer Driver No 67 0.141 23 0 0.0 3
ZNF445_ENST00000425708 ZNF445 P59923 Zinc finger protein 445 chr3 GO:0006259 Not Cancer Driver No 136 0.132 398 61 0.153 0
ZNF830 ZNF830 Q96NB3 Zinc finger protein 830 chr17 GO:0006259 Not Cancer Driver No 39 0.105 312 37 0.119 0
ZRANB3 ZRANB3 Q5FWF4 DNA annealing helicase and endonuclease ZRANB3 chr2 GO:0006259 Not Cancer Driver No 126 0.117 261 31 0.119 0