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Total number of protein in "GO:0005085" GO term:  221

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
ABR ABR Q12979 Active breakpoint cluster region-related protein chr17 GO:0005085 Not Cancer Driver No 122 0.142 184 36 0.196 0
ADRB1 ADRB1 P08588 Beta-1 adrenergic receptor chr10 GO:0005085 Not Cancer Driver No 35 0.073 116 1 0.009 0
AKAP13_ENST00000394518 AKAP13 Q12802 A-kinase anchor protein 13 chr15 GO:0005085 Not Cancer Driver No 359 0.128 2091 258 0.123 0
ALS2 ALS2 Q96Q42 Alsin chr2 GO:0005085 Not Cancer Driver No 194 0.117 353 36 0.102 0
ANKRD27 ANKRD27 Q96NW4 Ankyrin repeat domain-containing protein 27 chr19 GO:0005085 Not Cancer Driver No 145 0.138 239 33 0.138 0
ARF4 ARF4 P18085 ADP-ribosylation factor 4 chr3 GO:0005085 Not Cancer Driver No 17 0.094 0 0 0.0 0
ARFGEF1 ARFGEF1 Q9Y6D6 Brefeldin A-inhibited guanine nucleotide-exchange protein 1 chr8 GO:0005085 Not Cancer Driver No 243 0.131 456 54 0.118 0
ARFGEF2 ARFGEF2 Q9Y6D5 Brefeldin A-inhibited guanine nucleotide-exchange protein 2 chr20 GO:0005085 Not Cancer Driver No 254 0.142 358 63 0.176 0
ARFGEF3 ARFGEF3 Q5TH69 Brefeldin A-inhibited guanine nucleotide-exchange protein 3 chr6 GO:0005085 Not Cancer Driver No 258 0.119 584 58 0.099 0
ARHGEF10L ARHGEF10L Q9HCE6 Rho guanine nucleotide exchange factor 10-like protein chr1 GO:0005085 Census, Compendium Yes 155 0.121 431 47 0.109 0
ARHGEF10_ENST00000398564 ARHGEF10 O15013 Rho guanine nucleotide exchange factor 10 chr8 GO:0005085 Census, Compendium Yes 175 0.128 586 78 0.133 1
ARHGEF11_ENST00000361409 ARHGEF11 O15085 Rho guanine nucleotide exchange factor 11 chr1 GO:0005085 Not Cancer Driver No 213 0.14 1036 138 0.133 0
ARHGEF12 ARHGEF12 Q9NZN5 Rho guanine nucleotide exchange factor 12 chr11 GO:0005085 Census, Compendium Yes 212 0.137 972 150 0.154 0
ARHGEF15 ARHGEF15 O94989 Rho guanine nucleotide exchange factor 15 chr17 GO:0005085 Not Cancer Driver No 156 0.185 536 97 0.181 0
ARHGEF16 ARHGEF16 Q5VV41 Rho guanine nucleotide exchange factor 16 chr1 GO:0005085 Not Cancer Driver No 68 0.096 297 13 0.044 0
ARHGEF17 ARHGEF17 Q96PE2 Rho guanine nucleotide exchange factor 17 chr11 GO:0005085 Not Cancer Driver No 237 0.115 1408 170 0.121 0
ARHGEF19 ARHGEF19 Q8IW93 Rho guanine nucleotide exchange factor 19 chr1 GO:0005085 Not Cancer Driver No 82 0.102 365 36 0.099 0
ARHGEF1_ENST00000354532 ARHGEF1 Q92888 Rho guanine nucleotide exchange factor 1 chr19 GO:0005085 Not Cancer Driver No 127 0.139 457 67 0.147 0
ARHGEF2 ARHGEF2 Q92974 Rho guanine nucleotide exchange factor 2 chr1 GO:0005085 Not Cancer Driver No 146 0.148 450 70 0.156 0
ARHGEF25_ENST00000286494 ARHGEF25 Q86VW2 Rho guanine nucleotide exchange factor 25 chr12 GO:0005085 Not Cancer Driver No 80 0.138 241 35 0.145 0
ARHGEF26 ARHGEF26 Q96DR7 Rho guanine nucleotide exchange factor 26 chr3 GO:0005085 Not Cancer Driver No 164 0.188 475 86 0.181 0
ARHGEF28_ENST00000426542 ARHGEF28 Q8N1W1 Rho guanine nucleotide exchange factor 28 chr5 GO:0005085 Not Cancer Driver No 188 0.11 764 88 0.115 0
ARHGEF33_ENST00000398800 ARHGEF33 A8MVX0 Rho guanine nucleotide exchange factor 33 chr2 GO:0005085 Not Cancer Driver No 57 0.068 580 42 0.072 0
ARHGEF37 ARHGEF37 A1IGU5 Rho guanine nucleotide exchange factor 37 chr5 GO:0005085 Not Cancer Driver No 88 0.13 165 31 0.188 0
ARHGEF38 ARHGEF38 Q9NXL2 Rho guanine nucleotide exchange factor 38 chr4 GO:0005085 Not Cancer Driver No 30 0.039 156 12 0.077 0
ARHGEF39 ARHGEF39 Q8N4T4 Rho guanine nucleotide exchange factor 39 chr9 GO:0005085 Not Cancer Driver No 45 0.134 56 5 0.089 0
ARHGEF3_ENST00000296315 ARHGEF3 Q9NR81 Rho guanine nucleotide exchange factor 3 chr3 GO:0005085 Not Cancer Driver No 70 0.133 154 17 0.11 0
ARHGEF4 ARHGEF4 Q9NR80 Rho guanine nucleotide exchange factor 4 chr2 GO:0005085 Not Cancer Driver No 114 0.165 287 61 0.213 0
ARHGEF40 ARHGEF40 Q8TER5 Rho guanine nucleotide exchange factor 40 chr14 GO:0005085 Not Cancer Driver No 161 0.106 781 75 0.096 0
ARHGEF5 ARHGEF5 Q12774 Rho guanine nucleotide exchange factor 5 chr7 GO:0005085 Not Cancer Driver No 170 0.106 1141 127 0.111 0
ARHGEF6 ARHGEF6 Q15052 Rho guanine nucleotide exchange factor 6 chrX GO:0005085 Not Cancer Driver No 158 0.204 223 45 0.202 0
ARHGEF7 ARHGEF7 Q14155 Rho guanine nucleotide exchange factor 7 chr13 GO:0005085 Not Cancer Driver No 106 0.132 301 39 0.13 0
ARHGEF9 ARHGEF9 O43307 Rho guanine nucleotide exchange factor 9 chrX GO:0005085 Not Cancer Driver No 97 0.188 88 7 0.08 2
BCAR3_ENST00000260502 BCAR3 O75815 Breast cancer anti-estrogen resistance protein 3 chr1 GO:0005085 Not Cancer Driver No 102 0.124 395 42 0.106 0
BCR BCR P11274 Breakpoint cluster region protein chr22 GO:0005085 Census, Compendium Yes 146 0.115 603 69 0.114 0
C9orf72 C9orf72 Q96LT7 Guanine nucleotide exchange factor C9orf72 chr9 GO:0005085 Not Cancer Driver No 64 0.133 11 0 0.0 0
CCDC88A_ENST00000642200 CCDC88A Q3V6T2 Girdin chr2 GO:0005085 Not Cancer Driver No 226 0.121 1481 173 0.117 0
CCDC88C CCDC88C Q9P219 Protein Daple chr14 GO:0005085 Not Cancer Driver No 270 0.133 1604 225 0.14 1
CCZ1 CCZ1 P86791 Vacuolar fusion protein CCZ1 homolog chr7 GO:0005085 Not Cancer Driver No 40 0.083 43 3 0.07 0
CYSLTR2_ENST00000614739 CYSLTR2 Q9NS75 Cysteinyl leukotriene receptor 2 chr13 GO:0005085 Census, Compendium Yes 64 0.185 0 0 0.0 0
CYTH1_ENST00000446868 CYTH1 Q15438 Cytohesin-1 chr17 GO:0005085 Not Cancer Driver No 59 0.148 93 15 0.161 0
CYTH2_ENST00000641098 CYTH2 Q99418 Cytohesin-2 chr19 GO:0005085 Not Cancer Driver No 55 0.138 93 12 0.129 0
CYTH3_ENST00000396741 CYTH3 O43739 Cytohesin-3 chr7 GO:0005085 Not Cancer Driver No 49 0.122 96 12 0.125 0
CYTH4 CYTH4 Q9UIA0 Cytohesin-4 chr22 GO:0005085 Not Cancer Driver No 70 0.178 52 10 0.192 0
DEF6 DEF6 Q9H4E7 Differentially expressed in FDCP 6 homolog chr6 GO:0005085 Not Cancer Driver No 72 0.114 336 30 0.089 0
DENND1A DENND1A Q8TEH3 DENN domain-containing protein 1A chr9 GO:0005085 Not Cancer Driver No 117 0.116 589 76 0.129 0
DENND1B DENND1B Q6P3S1 DENN domain-containing protein 1B chr1 GO:0005085 Not Cancer Driver No 69 0.089 299 19 0.064 0
DENND1C DENND1C Q8IV53 DENN domain-containing protein 1C chr19 GO:0005085 Not Cancer Driver No 102 0.127 369 54 0.146 0
DENND2A_ENST00000496613 DENND2A Q9ULE3 DENN domain-containing protein 2A chr7 GO:0005085 Not Cancer Driver No 189 0.187 539 109 0.202 0
DENND2C_ENST00000393277 DENND2C Q68D51 DENN domain-containing protein 2C chr1 GO:0005085 Not Cancer Driver No 177 0.191 351 69 0.197 0
DENND2D DENND2D Q9H6A0 DENN domain-containing protein 2D chr1 GO:0005085 Not Cancer Driver No 67 0.142 54 6 0.111 0
DENND3 DENND3 A2RUS2 DENN domain-containing protein 3 chr8 GO:0005085 Not Cancer Driver No 192 0.16 118 22 0.186 0
DENND4A_ENST00000431932 DENND4A Q7Z401 C-myc promoter-binding protein chr15 GO:0005085 Not Cancer Driver No 199 0.107 570 64 0.112 0
DENND4B DENND4B O75064 DENN domain-containing protein 4B chr1 GO:0005085 Not Cancer Driver No 201 0.134 498 72 0.145 0
DENND4C_ENST00000602925 DENND4C Q5VZ89 DENN domain-containing protein 4C chr9 GO:0005085 Not Cancer Driver No 190 0.1 710 69 0.097 0
DENND5A DENND5A Q6IQ26 DENN domain-containing protein 5A chr11 GO:0005085 Not Cancer Driver No 134 0.104 231 21 0.091 0
DENND5B_ENST00000389082 DENND5B Q6ZUT9 DENN domain-containing protein 5B chr12 GO:0005085 Not Cancer Driver No 171 0.134 194 23 0.119 0
DENND6A DENND6A Q8IWF6 Protein DENND6A chr3 GO:0005085 Not Cancer Driver No 54 0.089 69 2 0.029 0
DENND6B DENND6B Q8NEG7 Protein DENND6B chr22 GO:0005085 Not Cancer Driver No 46 0.079 53 3 0.057 0
DIS3 DIS3 Q9Y2L1 Exosome complex exonuclease RRP44 chr13 GO:0005085 Compendium Yes 121 0.126 235 32 0.136 0
DNMBP DNMBP Q6XZF7 Dynamin-binding protein chr10 GO:0005085 Not Cancer Driver No 208 0.132 758 92 0.121 0
DOCK10 DOCK10 Q96BY6 Dedicator of cytokinesis protein 10 chr2 GO:0005085 Not Cancer Driver No 368 0.168 409 58 0.142 0
DOCK11 DOCK11 Q5JSL3 Dedicator of cytokinesis protein 11 chrX GO:0005085 Not Cancer Driver No 312 0.151 240 29 0.121 0
DOCK1_ENST00000280333 DOCK1 Q14185 Dedicator of cytokinesis protein 1 chr10 GO:0005085 Not Cancer Driver No 240 0.129 360 52 0.144 0
DOCK2 DOCK2 Q92608 Dedicator of cytokinesis protein 2 chr5 GO:0005085 Not Cancer Driver No 480 0.262 266 79 0.297 2
DOCK3 DOCK3 Q8IZD9 Dedicator of cytokinesis protein 3 chr3 GO:0005085 Not Cancer Driver No 365 0.18 458 69 0.151 0
DOCK4 DOCK4 Q8N1I0 Dedicator of cytokinesis protein 4 chr7 GO:0005085 Not Cancer Driver No 331 0.168 397 80 0.202 0
DOCK5 DOCK5 Q9H7D0 Dedicator of cytokinesis protein 5 chr8 GO:0005085 Not Cancer Driver No 278 0.149 330 45 0.136 0
DOCK6 DOCK6 Q96HP0 Dedicator of cytokinesis protein 6 chr19 GO:0005085 Not Cancer Driver No 203 0.099 496 57 0.115 0
DOCK7_ENST00000635253 DOCK7 Q96N67 Dedicator of cytokinesis protein 7 chr1 GO:0005085 Not Cancer Driver No 262 0.122 454 53 0.117 0
DOCK8 DOCK8 Q8NF50 Dedicator of cytokinesis protein 8 chr9 GO:0005085 Not Cancer Driver No 321 0.153 312 60 0.192 1
DOCK9 DOCK9 Q9BZ29 Dedicator of cytokinesis protein 9 chr13 GO:0005085 Not Cancer Driver No 236 0.114 180 20 0.111 0
ECT2 ECT2 Q9H8V3 Protein ECT2 chr3 GO:0005085 Not Cancer Driver No 104 0.114 284 33 0.116 0
ECT2L ECT2L Q008S8 Epithelial cell-transforming sequence 2 oncogene-like chr6 GO:0005085 Census Yes 131 0.145 31 7 0.226 0
EEF1B2_ENST00000236957 EEF1B2 P24534 Elongation factor 1-beta chr2 GO:0005085 Not Cancer Driver No 63 0.28 71 11 0.155 0
EEF1D_ENST00000395119 EEF1D P29692 Elongation factor 1-delta chr8 GO:0005085 Not Cancer Driver No 40 0.142 153 22 0.144 0
EGF EGF P01133 Pro-epidermal growth factor chr4 GO:0005085 Not Cancer Driver No 184 0.152 191 25 0.131 1
EIF2B1 EIF2B1 Q14232 Translation initiation factor eIF-2B subunit alpha chr12 GO:0005085 Not Cancer Driver No 33 0.108 0 0 0.0 2
EIF2B2 EIF2B2 P49770 Translation initiation factor eIF-2B subunit beta chr14 GO:0005085 Not Cancer Driver No 40 0.114 83 11 0.133 9
EIF2B3 EIF2B3 Q9NR50 Translation initiation factor eIF-2B subunit gamma chr1 GO:0005085 Not Cancer Driver No 54 0.119 28 9 0.321 5
EIF2B4_ENST00000347454 EIF2B4 Q9UI10 Translation initiation factor eIF-2B subunit delta chr2 GO:0005085 Not Cancer Driver No 57 0.109 212 29 0.137 7
EIF2B5 EIF2B5 Q13144 Translation initiation factor eIF-2B subunit epsilon chr3 GO:0005085 Not Cancer Driver No 76 0.105 179 16 0.089 29
ELMO1_ENST00000448602 ELMO1 Q92556 Engulfment and cell motility protein 1 chr7 GO:0005085 Not Cancer Driver No 199 0.274 98 22 0.224 0
EPS8L1 EPS8L1 Q8TE68 Epidermal growth factor receptor kinase substrate 8-like protein 1 chr19 GO:0005085 Not Cancer Driver No 116 0.16 521 96 0.184 0
EPS8L2_ENST00000530636 EPS8L2 Q9H6S3 Epidermal growth factor receptor kinase substrate 8-like protein 2 chr11 GO:0005085 Not Cancer Driver No 68 0.095 372 31 0.083 0
EPS8L3_ENST00000361965 EPS8L3 Q8TE67 Epidermal growth factor receptor kinase substrate 8-like protein 3 chr1 GO:0005085 Not Cancer Driver No 105 0.177 338 57 0.169 0
FAM45A DENND10 Q8TCE6 DENN domain-containing protein 10 chr10 GO:0005085 Not Cancer Driver No 33 0.092 13 1 0.077 0
FARP1_ENST00000319562 FARP1 Q9Y4F1 FERM, ARHGEF and pleckstrin domain-containing protein 1 chr13 GO:0005085 Not Cancer Driver No 147 0.141 315 60 0.19 0
FARP2 FARP2 O94887 FERM, ARHGEF and pleckstrin domain-containing protein 2 chr2 GO:0005085 Not Cancer Driver No 133 0.126 250 39 0.156 0
FBXO8 FBXO8 Q9NRD0 F-box only protein 8 chr4 GO:0005085 Not Cancer Driver No 46 0.144 25 1 0.04 0
FGD1 FGD1 P98174 FYVE, RhoGEF and PH domain-containing protein 1 chrX GO:0005085 Not Cancer Driver No 139 0.145 520 74 0.142 5
FGD2 FGD2 Q7Z6J4 FYVE, RhoGEF and PH domain-containing protein 2 chr6 GO:0005085 Not Cancer Driver No 113 0.173 158 26 0.165 0
FGD3 FGD3 Q5JSP0 FYVE, RhoGEF and PH domain-containing protein 3 chr9 GO:0005085 Not Cancer Driver No 117 0.161 404 72 0.178 0
FGD4_ENST00000427716 FGD4 Q96M96 FYVE, RhoGEF and PH domain-containing protein 4 chr12 GO:0005085 Not Cancer Driver No 78 0.102 290 28 0.097 2
FGD5 FGD5 Q6ZNL6 FYVE, RhoGEF and PH domain-containing protein 5 chr3 GO:0005085 Compendium Yes 275 0.188 915 180 0.197 0
FGD6 FGD6 Q6ZV73 FYVE, RhoGEF and PH domain-containing protein 6 chr12 GO:0005085 Not Cancer Driver No 198 0.138 804 117 0.146 0
FLCN FLCN Q8NFG4 Folliculin chr17 GO:0005085 Census, Compendium Yes 59 0.102 157 19 0.121 5
FNIP1 FNIP1 Q8TF40 Folliculin-interacting protein 1 chr5 GO:0005085 Not Cancer Driver No 143 0.123 384 44 0.115 0
FRMD7 FRMD7 Q6ZUT3 FERM domain-containing protein 7 chrX GO:0005085 Not Cancer Driver No 147 0.206 256 59 0.23 25
GAPVD1_ENST00000495955 GAPVD1 Q14C86 GTPase-activating protein and VPS9 domain-containing protein 1 chr9 GO:0005085 Not Cancer Driver No 188 0.127 705 93 0.132 0
GBF1 GBF1 Q92538 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 chr10 GO:0005085 Not Cancer Driver No 216 0.116 669 76 0.114 0
GDPGP1 GDPGP1 Q6ZNW5 GDP-D-glucose phosphorylase 1 chr15 GO:0005085 Not Cancer Driver No 44 0.114 83 9 0.108 0
GNA13 GNA13 Q14344 Guanine nucleotide-binding protein subunit alpha-13 chr17 GO:0005085 Compendium Yes 52 0.138 32 4 0.125 0
HERC1 HERC1 Q15751 Probable E3 ubiquitin-protein ligase HERC1 chr15 GO:0005085 Not Cancer Driver No 487 0.1 1344 129 0.096 1
HERC2 HERC2 O95714 E3 ubiquitin-protein ligase HERC2 chr15 GO:0005085 Compendium Yes 718 0.149 971 150 0.154 1
HPS1_ENST00000613394 HPS1 Q92902 Hermansky-Pudlak syndrome 1 protein chr10 GO:0005085 Not Cancer Driver No 72 0.103 154 16 0.104 0
HPS4_ENST00000336873 HPS4 Q9NQG7 Hermansky-Pudlak syndrome 4 protein chr22 GO:0005085 Not Cancer Driver No 96 0.136 343 57 0.166 0
IQSEC1_ENST00000273221 IQSEC1 Q6DN90 IQ motif and SEC7 domain-containing protein 1 chr3 GO:0005085 Not Cancer Driver No 141 0.146 610 97 0.159 2
IQSEC2_ENST00000396435 IQSEC2 Q5JU85 IQ motif and SEC7 domain-containing protein 2 chrX GO:0005085 Not Cancer Driver No 163 0.11 1139 97 0.085 5
IQSEC3 IQSEC3 Q9UPP2 IQ motif and SEC7 domain-containing protein 3 chr12 GO:0005085 Not Cancer Driver No 166 0.14 682 85 0.125 0
ITSN1 ITSN1 Q15811 Intersectin-1 chr21 GO:0005085 Not Cancer Driver No 214 0.124 797 107 0.134 0
ITSN2 ITSN2 Q9NZM3 Intersectin-2 chr2 GO:0005085 Not Cancer Driver No 207 0.122 680 92 0.135 0
KALRN_ENST00000360013 KALRN O60229 Kalirin chr3 GO:0005085 Not Cancer Driver No 544 0.182 732 128 0.175 0
KIAA1147 DENND11 A4D1U4 DENN domain-containing protein 11 chr7 GO:0005085 Not Cancer Driver No 54 0.119 82 0 0.0 0
KNDC1 KNDC1 Q76NI1 Kinase non-catalytic C-lobe domain-containing protein 1 chr10 GO:0005085 Not Cancer Driver No 276 0.158 805 124 0.154 0
LAMTOR1 LAMTOR1 Q6IAA8 Ragulator complex protein LAMTOR1 chr11 GO:0005085 Not Cancer Driver No 13 0.081 96 7 0.073 0
LAMTOR2 LAMTOR2 Q9Y2Q5 Ragulator complex protein LAMTOR2 chr1 GO:0005085 Not Cancer Driver No 12 0.096 0 0 0.0 0
LAMTOR3 LAMTOR3 Q9UHA4 Ragulator complex protein LAMTOR3 chr4 GO:0005085 Not Cancer Driver No 12 0.097 0 0 0.0 0
LAMTOR4 LAMTOR4 Q0VGL1 Ragulator complex protein LAMTOR4 chr7 GO:0005085 Not Cancer Driver No 8 0.081 4 0 0.0 0
LAMTOR5_ENST00000602318 LAMTOR5 O43504 Ragulator complex protein LAMTOR5 chr1 GO:0005085 Not Cancer Driver No 10 0.11 17 0 0.0 0
MADD MADD Q8WXG6 MAP kinase-activating death domain protein chr11 GO:0005085 Not Cancer Driver No 207 0.126 723 81 0.112 4
MCF2L2 MCF2L2 Q86YR7 Probable guanine nucleotide exchange factor MCF2L2 chr3 GO:0005085 Not Cancer Driver No 222 0.199 306 61 0.199 0
MCF2L_ENST00000375608 MCF2L O15068 Guanine nucleotide exchange factor DBS chr13 GO:0005085 Not Cancer Driver No 173 0.152 410 54 0.132 0
MCF2_ENST00000370576 MCF2 P10911 Proto-oncogene DBL chrX GO:0005085 Not Cancer Driver No 218 0.236 124 33 0.266 0
MON1A MON1A Q86VX9 Vacuolar fusion protein MON1 homolog A chr3 GO:0005085 Not Cancer Driver No 54 0.083 260 14 0.054 0
MYCBP2_ENST00000357337 MYCBP2 O75592 E3 ubiquitin-protein ligase MYCBP2 chr13 GO:0005085 Not Cancer Driver No 608 0.13 1398 189 0.135 0
NET1 NET1 Q7Z628 Neuroepithelial cell-transforming gene 1 protein chr10 GO:0005085 Not Cancer Driver No 60 0.101 294 37 0.126 0
NGEF NGEF Q8N5V2 Ephexin-1 chr2 GO:0005085 Not Cancer Driver No 125 0.176 296 34 0.115 0
NUCB1 NUCB1 Q02818 Nucleobindin-1 chr19 GO:0005085 Not Cancer Driver No 56 0.121 352 43 0.122 0
NUCB2_ENST00000622082 NUCB2 P80303 Nucleobindin-2 chr11 GO:0005085 Not Cancer Driver No 49 0.117 265 40 0.151 0
OBSCN_ENST00000422127 OBSCN Q5VST9 Obscurin chr1 GO:0005085 Not Cancer Driver No 1208 0.152 2623 368 0.14 0
P2RY12 P2RY12 Q9H244 P2Y purinoceptor 12 chr3 GO:0005085 Not Cancer Driver No 57 0.167 21 2 0.095 3
PCP2 PCP2 Q8IVA1 Purkinje cell protein 2 homolog chr19 GO:0005085 Not Cancer Driver No 13 0.096 136 13 0.096 0
PLCD4_ENST00000417849 PLCD4 Q9BRC7 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 chr2 GO:0005085 Not Cancer Driver No 78 0.102 90 5 0.056 0
PLCE1 PLCE1 Q9P212 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 chr10 GO:0005085 Not Cancer Driver No 367 0.159 780 107 0.137 1
PLEKHG1 PLEKHG1 Q9ULL1 Pleckstrin homology domain-containing family G member 1 chr6 GO:0005085 Not Cancer Driver No 182 0.131 888 119 0.134 0
PLEKHG2 PLEKHG2 Q9H7P9 Pleckstrin homology domain-containing family G member 2 chr19 GO:0005085 Not Cancer Driver No 168 0.121 1053 139 0.132 1
PLEKHG3 PLEKHG3 A1L390 Pleckstrin homology domain-containing family G member 3 chr14 GO:0005085 Not Cancer Driver No 137 0.112 885 104 0.118 0
PLEKHG4 PLEKHG4 Q58EX7 Puratrophin-1 chr16 GO:0005085 Not Cancer Driver No 132 0.111 295 35 0.119 0
PLEKHG4B PLEKHG4B Q96PX9 Pleckstrin homology domain-containing family G member 4B chr5 GO:0005085 Not Cancer Driver No 234 0.184 704 107 0.152 0
PLEKHG5_ENST00000400913 PLEKHG5 O94827 Pleckstrin homology domain-containing family G member 5 chr1 GO:0005085 Not Cancer Driver No 93 0.092 537 54 0.101 3
PLEKHG6_ENST00000011684 PLEKHG6 Q3KR16 Pleckstrin homology domain-containing family G member 6 chr12 GO:0005085 Not Cancer Driver No 103 0.13 471 65 0.138 0
PREB PREB Q9HCU5 Prolactin regulatory element-binding protein chr2 GO:0005085 Not Cancer Driver No 56 0.134 91 10 0.11 0
PREX1 PREX1 Q8TCU6 Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein chr20 GO:0005085 Not Cancer Driver No 297 0.179 307 55 0.179 0
PREX2 PREX2 Q70Z35 Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein chr8 GO:0005085 Census, Compendium Yes 492 0.306 234 68 0.291 0
PSD PSD A5PKW4 PH and SEC7 domain-containing protein 1 chr10 GO:0005085 Not Cancer Driver No 173 0.169 714 130 0.182 0
PSD2 PSD2 Q9BQI7 PH and SEC7 domain-containing protein 2 chr5 GO:0005085 Not Cancer Driver No 155 0.201 398 87 0.219 0
PSD3_ENST00000440756 PSD3 Q9NYI0 PH and SEC7 domain-containing protein 3 chr8 GO:0005085 Not Cancer Driver No 146 0.139 645 94 0.146 0
PSD4 PSD4 Q8NDX1 PH and SEC7 domain-containing protein 4 chr2 GO:0005085 Not Cancer Driver No 157 0.149 739 103 0.139 0
PTGIR PTGIR P43119 Prostacyclin receptor chr19 GO:0005085 Not Cancer Driver No 40 0.104 47 4 0.085 0
RAB3GAP1_ENST00000264158 RAB3GAP1 Q15042 Rab3 GTPase-activating protein catalytic subunit chr2 GO:0005085 Not Cancer Driver No 123 0.125 294 32 0.109 2
RAB3GAP2 RAB3GAP2 Q9H2M9 Rab3 GTPase-activating protein non-catalytic subunit chr1 GO:0005085 Not Cancer Driver No 168 0.121 143 17 0.119 2
RAB3IL1 RAB3IL1 Q8TBN0 Guanine nucleotide exchange factor for Rab-3A chr11 GO:0005085 Not Cancer Driver No 41 0.107 217 18 0.083 0
RAB3IP RAB3IP Q96QF0 Rab-3A-interacting protein chr12 GO:0005085 Not Cancer Driver No 85 0.179 227 33 0.145 0
RABGEF1_ENST00000284957 RABGEF1 Q9UJ41 Rab5 GDP/GTP exchange factor chr7 GO:0005085 Not Cancer Driver No 73 0.149 175 35 0.2 0
RABIF RABIF P47224 Guanine nucleotide exchange factor MSS4 chr1 GO:0005085 Not Cancer Driver No 10 0.081 25 3 0.12 0
RALGDS RALGDS Q12967 Ral guanine nucleotide dissociation stimulator chr9 GO:0005085 Census, Compendium Yes 104 0.114 379 44 0.116 0
RALGPS1 RALGPS1 Q5JS13 Ras-specific guanine nucleotide-releasing factor RalGPS1 chr9 GO:0005085 Not Cancer Driver No 62 0.111 219 26 0.119 0
RALGPS2 RALGPS2 Q86X27 Ras-specific guanine nucleotide-releasing factor RalGPS2 chr1 GO:0005085 Not Cancer Driver No 83 0.142 183 23 0.126 0
RANGRF RANGRF Q9HD47 Ran guanine nucleotide release factor chr17 GO:0005085 Not Cancer Driver No 10 0.054 42 5 0.119 0
RAP1A_ENST00000356415 RAP1A P62834 Ras-related protein Rap-1A chr1 GO:0005085 Not Cancer Driver No 27 0.147 5 0 0.0 0
RAPGEF1_ENST00000372189 RAPGEF1 Q13905 Rap guanine nucleotide exchange factor 1 chr9 GO:0005085 Not Cancer Driver No 158 0.147 589 87 0.148 0
RAPGEF2 RAPGEF2 Q9Y4G8 Rap guanine nucleotide exchange factor 2 chr4 GO:0005085 Not Cancer Driver No 216 0.144 803 116 0.144 0
RAPGEF3 RAPGEF3 O95398 Rap guanine nucleotide exchange factor 3 chr12 GO:0005085 Not Cancer Driver No 97 0.105 197 19 0.096 0
RAPGEF4 RAPGEF4 Q8WZA2 Rap guanine nucleotide exchange factor 4 chr2 GO:0005085 Not Cancer Driver No 149 0.147 191 29 0.152 0
RAPGEF5_ENST00000401957 RAPGEF5 Q92565 Rap guanine nucleotide exchange factor 5 chr7 GO:0005085 Not Cancer Driver No 73 0.126 56 10 0.179 0
RAPGEF6_ENST00000509018 RAPGEF6 Q8TEU7 Rap guanine nucleotide exchange factor 6 chr5 GO:0005085 Not Cancer Driver No 192 0.12 789 92 0.117 0
RAPGEFL1_ENST00000620260 RAPGEFL1 Q9UHV5 Rap guanine nucleotide exchange factor-like 1 chr17 GO:0005085 Not Cancer Driver No 49 0.074 200 3 0.015 0
RASGEF1A_ENST00000395810 RASGEF1A Q8N9B8 Ras-GEF domain-containing family member 1A chr10 GO:0005085 Not Cancer Driver No 69 0.143 66 11 0.167 0
RASGEF1B RASGEF1B Q0VAM2 Ras-GEF domain-containing family member 1B chr4 GO:0005085 Not Cancer Driver No 66 0.14 27 6 0.222 0
RASGEF1C RASGEF1C Q8N431 Ras-GEF domain-containing family member 1C chr5 GO:0005085 Not Cancer Driver No 80 0.172 62 9 0.145 0
RASGRF1 RASGRF1 Q13972 Ras-specific guanine nucleotide-releasing factor 1 chr15 GO:0005085 Not Cancer Driver No 226 0.178 332 64 0.193 0
RASGRF2 RASGRF2 O14827 Ras-specific guanine nucleotide-releasing factor 2 chr5 GO:0005085 Not Cancer Driver No 216 0.175 274 55 0.201 0
RASGRP1 RASGRP1 O95267 RAS guanyl-releasing protein 1 chr15 GO:0005085 Not Cancer Driver No 96 0.12 191 12 0.063 1
RASGRP2_ENST00000377497 RASGRP2 Q7LDG7 RAS guanyl-releasing protein 2 chr11 GO:0005085 Not Cancer Driver No 98 0.161 88 15 0.17 4
RASGRP3_ENST00000402538 RASGRP3 Q8IV61 Ras guanyl-releasing protein 3 chr2 GO:0005085 Not Cancer Driver No 119 0.172 145 20 0.138 0
RASGRP4_ENST00000587738 RASGRP4 Q8TDF6 RAS guanyl-releasing protein 4 chr19 GO:0005085 Not Cancer Driver No 96 0.143 184 40 0.217 0
RCBTB2_ENST00000344532 RCBTB2 O95199 RCC1 and BTB domain-containing protein 2 chr13 GO:0005085 Not Cancer Driver No 86 0.156 36 3 0.083 0
RCC1L RCC1L Q96I51 RCC1-like G exchanging factor-like protein chr7 GO:0005085 Not Cancer Driver No 19 0.041 87 7 0.08 0
RCC1_ENST00000373833 RCC1 P18754 Regulator of chromosome condensation chr1 GO:0005085 Not Cancer Driver No 54 0.128 143 15 0.105 0
RCC2 RCC2 Q9P258 Protein RCC2 chr1 GO:0005085 Not Cancer Driver No 63 0.121 194 27 0.139 0
RGL1_ENST00000360851 RGL1 Q9NZL6 Ral guanine nucleotide dissociation stimulator-like 1 chr1 GO:0005085 Not Cancer Driver No 106 0.138 295 41 0.139 0
RGL2 RGL2 O15211 Ral guanine nucleotide dissociation stimulator-like 2 chr6 GO:0005085 Not Cancer Driver No 87 0.112 461 51 0.111 0
RGL3_ENST00000380456 RGL3 Q3MIN7 Ral guanine nucleotide dissociation stimulator-like 3 chr19 GO:0005085 Compendium Yes 90 0.127 406 57 0.14 0
RGL4 RGL4 Q8IZJ4 Ral-GDS-related protein chr22 GO:0005085 Not Cancer Driver No 51 0.108 175 18 0.103 0
RGP1 RGP1 Q92546 RAB6A-GEF complex partner protein 2 chr9 GO:0005085 Not Cancer Driver No 44 0.113 120 13 0.108 0
RHOD RHOD O00212 Rho-related GTP-binding protein RhoD chr11 GO:0005085 Not Cancer Driver No 20 0.095 10 0 0.0 0
RHOF RHOF Q9HBH0 Rho-related GTP-binding protein RhoF chr12 GO:0005085 Not Cancer Driver No 18 0.085 10 0 0.0 0
RHOU RHOU Q7L0Q8 Rho-related GTP-binding protein RhoU chr1 GO:0005085 Not Cancer Driver No 34 0.132 63 6 0.095 0
RIC1 RIC1 Q4ADV7 Guanine nucleotide exchange factor subunit RIC1 chr9 GO:0005085 Not Cancer Driver No 159 0.112 252 15 0.06 1
RIC8A_ENST00000526104 RIC8A Q9NPQ8 Synembryn-A chr11 GO:0005085 Not Cancer Driver No 63 0.119 163 23 0.141 0
RIC8B_ENST00000392839 RIC8B Q9NVN3 Synembryn-B chr12 GO:0005085 Not Cancer Driver No 58 0.112 117 20 0.171 0
RIN1 RIN1 Q13671 Ras and Rab interactor 1 chr11 GO:0005085 Not Cancer Driver No 76 0.097 376 43 0.114 0
RIN3 RIN3 Q8TB24 Ras and Rab interactor 3 chr14 GO:0005085 Not Cancer Driver No 137 0.139 417 61 0.146 0
RINL RINL Q6ZS11 Ras and Rab interactor-like protein chr19 GO:0005085 Not Cancer Driver No 50 0.088 367 32 0.087 0
RPGR_ENST00000339363 RPGR Q92834 X-linked retinitis pigmentosa GTPase regulator chrX GO:0005085 Not Cancer Driver No 115 0.113 639 64 0.1 25
SBF1_ENST00000348911 SBF1 O95248 Myotubularin-related protein 5 chr22 GO:0005085 Not Cancer Driver No 210 0.112 632 63 0.1 2
SBF2 SBF2 Q86WG5 Myotubularin-related protein 13 chr11 GO:0005085 Not Cancer Driver No 221 0.12 367 55 0.15 0
SERGEF SERGEF Q9UGK8 Secretion-regulating guanine nucleotide exchange factor chr11 GO:0005085 Not Cancer Driver No 49 0.107 91 7 0.077 0
SH2D3A SH2D3A Q9BRG2 SH2 domain-containing protein 3A chr19 GO:0005085 Not Cancer Driver No 68 0.118 305 40 0.131 0
SH2D3C SH2D3C Q8N5H7 SH2 domain-containing protein 3C chr9 GO:0005085 Not Cancer Driver No 110 0.128 440 72 0.164 0
SH3BP5 SH3BP5 O60239 SH3 domain-binding protein 5 chr3 GO:0005085 Not Cancer Driver No 46 0.101 378 35 0.093 0
SH3BP5L SH3BP5L Q7L8J4 SH3 domain-binding protein 5-like chr1 GO:0005085 Not Cancer Driver No 62 0.158 376 57 0.152 0
SMCR8 SMCR8 Q8TEV9 Guanine nucleotide exchange protein SMCR8 chr17 GO:0005085 Not Cancer Driver No 107 0.114 357 38 0.106 0
SOS1_ENST00000402219 SOS1 Q07889 Son of sevenless homolog 1 chr2 GO:0005085 Compendium Yes 197 0.148 458 62 0.135 38
SOS2 SOS2 Q07890 Son of sevenless homolog 2 chr14 GO:0005085 Not Cancer Driver No 173 0.13 362 54 0.149 2
SPATA13_ENST00000382095 SPATA13 Q96N96 Spermatogenesis-associated protein 13 chr13 GO:0005085 Not Cancer Driver No 68 0.104 263 32 0.122 0
ST5 DENND2B P78524 DENN domain-containing protein 2B chr11 GO:0005085 Not Cancer Driver No 144 0.127 671 93 0.139 0
SWAP70 SWAP70 Q9UH65 Switch-associated protein 70 chr11 GO:0005085 Not Cancer Driver No 44 0.075 271 18 0.066 0
TAGAP TAGAP Q8N103 T-cell activation Rho GTPase-activating protein chr6 GO:0005085 Not Cancer Driver No 114 0.156 457 76 0.166 0
TBC1D10A_ENST00000215790 TBC1D10A Q9BXI6 TBC1 domain family member 10A chr22 GO:0005085 Not Cancer Driver No 72 0.142 209 26 0.124 0
TBXA2R_ENST00000375190 TBXA2R P21731 Thromboxane A2 receptor chr19 GO:0005085 Not Cancer Driver No 47 0.137 17 4 0.235 1
THG1L THG1L Q9NWX6 Probable tRNA(His) guanylyltransferase chr5 GO:0005085 Not Cancer Driver No 32 0.107 22 2 0.091 1
TIAM1 TIAM1 Q13009 Rho guanine nucleotide exchange factor TIAM1 chr21 GO:0005085 Not Cancer Driver No 370 0.233 810 194 0.24 0
TIAM2 TIAM2 Q8IVF5 Rho guanine nucleotide exchange factor TIAM2 chr6 GO:0005085 Not Cancer Driver No 309 0.182 779 166 0.213 0
TRIO TRIO O75962 Triple functional domain protein chr5 GO:0005085 Not Cancer Driver No 400 0.129 1052 118 0.112 10
VAV1 VAV1 P15498 Proto-oncogene vav chr19 GO:0005085 Census, Compendium Yes 165 0.195 113 19 0.168 0
VAV2 VAV2 P52735 Guanine nucleotide exchange factor VAV2 chr9 GO:0005085 Not Cancer Driver No 127 0.145 135 17 0.126 0
VAV3 VAV3 Q9UKW4 Guanine nucleotide exchange factor VAV3 chr1 GO:0005085 Not Cancer Driver No 153 0.181 102 18 0.176 0
VPS9D1 VPS9D1 Q9Y2B5 VPS9 domain-containing protein 1 chr16 GO:0005085 Not Cancer Driver No 57 0.09 353 26 0.074 0
WDR41 WDR41 Q9HAD4 WD repeat-containing protein 41 chr5 GO:0005085 Not Cancer Driver No 48 0.105 23 2 0.087 0